Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Testosterone Propionate: An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.Orchiectomy: The surgical removal of one or both testicles.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Sex Hormone-Binding Globulin: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Epitestosterone: The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.Castration: Surgical removal or artificial destruction of gonads.Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.Testosterone Congeners: Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Sexual Maturation: Achievement of full sexual capacity in animals and in humans.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.3-Oxo-5-alpha-Steroid 4-Dehydrogenase: An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.Gonadotropin-Releasing Hormone: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.Hormone Replacement Therapy: Therapeutic use of hormones to alleviate the effects of hormone deficiency.Organ Size: The measurement of an organ in volume, mass, or heaviness.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Sex Characteristics: Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.Sexual Behavior, Animal: Sexual activities of animals.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Aromatase: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Libido: The psychic drive or energy associated with sexual instinct in the broad sense (pleasure and love-object seeking). It may also connote the psychic energy associated with instincts in general that motivate behavior.Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.Androstanes: The family of steroids from which the androgens are derived.Virilism: Development of male secondary SEX CHARACTERISTICS in the FEMALE. It is due to the effects of androgenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.Genitalia, Male: The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.Sperm Count: A count of SPERM in the ejaculum, expressed as number per milliliter.Gonadotropins, Pituitary: Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Seminal Vesicles: A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hormones: Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.17-Hydroxysteroid Dehydrogenases: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.Androsterone: A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.Cyproterone Acetate: An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.17-Ketosteroids: Steroids that contain a ketone group at position 17.5-alpha Reductase Inhibitors: Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.17-alpha-Hydroxyprogesterone: A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.Contraceptive Agents, Male: Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.Cholestenone 5 alpha-Reductase: An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.Hydroxytestosterones: 17 beta-Hydroxy-4-androsten-3-ones. Testosterone derivatives formed by the substitution of one or more hydroxyl groups in any position.Leuprolide: A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.Sertoli Cells: Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.Seminiferous Tubules: The convoluted tubules in the TESTIS where sperm are produced (SPERMATOGENESIS) and conveyed to the RETE TESTIS. Spermatogenic tubules are composed of developing germ cells and the supporting SERTOLI CELLS.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Gonadotropins: Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.Estrone: An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Inhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelySteroid 17-alpha-Hydroxylase: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Hyperandrogenism: A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Epididymis: The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Hydroxyprogesterones: Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.Steroid 16-alpha-Hydroxylase: A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Steroid Hydroxylases: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.Cryptorchidism: A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.Sex Differentiation: The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.Androgen-Insensitivity Syndrome: A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.Transsexualism: Severe gender dysphoria, coupled with a persistent desire for the physical characteristics and social roles that connote the opposite biological sex. (APA, DSM-IV, 1994)Ovary: The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.Scrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Andropause: An endocrine state in men, characterized by a significant decline in the production of TESTOSTERONE; DEHYDROEPIANDROSTERONE; and other hormones such as HUMAN GROWTH HORMONE. Andropause symptoms are related to the lack of androgens including DEPRESSION, sexual dysfunction, and OSTEOPOROSIS. Andropause may also result from hormonal ablation therapy for malignant diseases.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.Copulation: Sexual union of a male and a female in non-human species.Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).Puberty: A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Cholesterol Side-Chain Cleavage Enzyme: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Ovariectomy: The surgical removal of one or both ovaries.Territoriality: Behavior in defense of an area against another individual or individuals primarily of the same species.Hypophysectomy: Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)Social Dominance: Social structure of a group as it relates to the relative social rank of dominance status of its members. (APA, Thesaurus of Psychological Index Terms, 8th ed.)Aryl Hydrocarbon Hydroxylases: A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.Aromatase Inhibitors: Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.Preoptic Area: Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Receptors, LH: Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.Sexual Development: The processes of anatomical and physiological changes related to sexual or reproductive functions during the life span of a human or an animal, from FERTILIZATION to DEATH. These include SEX DETERMINATION PROCESSES; SEX DIFFERENTIATION; SEXUAL MATURATION; and changes during AGING.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.Pregnenolone: A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.Androgen-Binding Protein: Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.Antlers: The horn of an animal of the deer family, typically present only in the male. It differs from the HORNS of other animals in being a solid, generally branched bony outgrowth that is shed and renewed annually. The word antler comes from the Latin anteocularis, ante (before) + oculus (eye). (From Webster, 3d ed)Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.Gonadal Hormones: Hormones produced by the GONADS, including both steroid and peptide hormones. The major steroid hormones include ESTRADIOL and PROGESTERONE from the OVARY, and TESTOSTERONE from the TESTIS. The major peptide hormones include ACTIVINS and INHIBINS.Androstenediol: An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Penile Erection: The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.Ketosteroids: Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Desogestrel: A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Changed levels of endogenous sex steroids in women on oral contraceptives. (1/7518)
Serum and urinary levels of unconjugated testosterone, dihydrotestosterone, and oestradiol were measured by specific radioimmunoassays in 10 healthy women in the early follicular phase of their menstrual cycle and in nine healthy women taking oral contraceptives. The contraceptive group had testosterone levels 1-3 times higher and dihydrotestosterone levels two times higher than those in the controls. Serum oestradiol levels in the contraceptive group were much lower than those in the controls and similar to levels in postmenopausal women. The contraceptive group had about twice the urinary excretion of unconjugated (free) testosterone and dihydrotestosterone of the controls, but their excretion of unconjugated oestradiol was 2-7 times lower. The great increase in serum and urinary androgen concentrations, as well as the suppression of oestradiol, may be related to the antiovulatory effect of oral contraceptives. (+info)The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (2/7518)
We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent. (+info)Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat. (3/7518)
Hepatic microsome-catalyzed metabolism of aflatoxin B1 (AFB1) to aflatoxin M1 and aflatoxin Q1 and the "metabolic activation" of AFB1 to DNA-alylating metabolite(s) were studied in normal male and female Sprague-Dawley rats, in gonadectomized animals, and in castrated males and normal females treated with testosterone. Microsomes from male animals formed 2 to 5 times more aflatoxin M1, aflatoxin Q1, and DNA-alkylating metabolite(s) than those from females. Castration reduced the metabolism of AFB1 by the microsomes from males by about 50%, whereas ovariectomy had no significant effect on AFB1 metabolism by the microsomes from females. Testosterone treatment (4 mg/rat, 3 times/week for about 6 weeks) of castrated immature males and immature females enhanced the metabolism of AFB1 by their microsomes. A sex difference in the metabolism of AFB1 by liver microsomes was also seen in other strains of rats tested: Wistar, Long-Evans, and Fischer. The activity of kidney microsomes for metabolic activation was 1 to 4% that of the liver activity and was generally lower in microsomes from male rats as compared to those from female rats of Sprague-Dawley, Wistar, and Long-Evans strains. The in vitro results obtained with hepatic microsomes correlated well with the in vivo metabolism of AFB1, in that more AFB1 became bound in vivo to hepatic DNA isolated from male rats and from a female rat treated with testosterone than that isolated from control female rats. These data suggest that the differences in hepatic AFB1 metabolism may be the underlying cause of the sex difference in toxicity and carcinogenicity of AFB1 observed in rats. (+info)Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (4/7518)
Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex. (+info)Prolactin replacement fails to inhibit reactivation of gonadotropin secretion in rams treated with melatonin under long days. (5/7518)
This study tested the hypothesis that prolactin (PRL) inhibits gonadotropin secretion in rams maintained under long days and that treatment with melatonin (s.c. continuous-release implant; MEL-IMP) reactivates the reproductive axis by suppressing PRL secretion. Adult Soay rams were maintained under long days (16L:8D) and received 1) no further treatment (control, C); 2) MEL-IMP for 16 wk and injections of saline/vehicle for the first 8 wk (M); 3) MEL-IMP for 16 wk and exogenous PRL (s.c. 5 mg ovine PRL 3x daily) for the first 8 wk (M+P). The treatment with melatonin induced a rapid increase in the blood concentrations of FSH and testosterone, rapid growth of the testes, an increase in the frequency of LH pulses, and a decrease in the LH response to N-methyl-D,L-aspartic acid. The concomitant treatment with exogenous PRL had no effect on these reproductive responses but caused a significant delay in the timing of the sexual skin color and growth of the winter pelage. These results do not support the hypothesis and suggest that PRL at physiological long-day concentrations, while being totally ineffective as an inhibitor of gonadotropin secretion, acts in the peripheral tissues and skin to maintain summer characteristics. (+info)Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (6/7518)
The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes. (+info)Sex steroid and prolactin profiles in male American black bears (Ursus americanus) during denning. (7/7518)
Serum sex steroid and prolactin profiles were examined in the male American black bear, Ursus americanus during denning. Sera collected in December and the following March from 8 denning male black bears in Minnesota, U.S.A. were assayed for testosterone, estradiol-17 beta and prolactin. Eight bears were confirmed to be the denning mode based on a serum urea to creatinine ratio less than 10. Serum testosterone concentrations tended to increase from December to the subsequent March whereas serum estradiol-17 beta concentrations tended to decrease during this period. There were few changes in serum prolactin concentrations between December and March. These findings suggest that spermatogenesis and testicular steroidogenesis initiated during denning may be influenced by changes in serum sex steroid concentrations in the American black bear. (+info)BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain. (8/7518)
New neurons are incorporated into the high vocal center (HVC), a nucleus of the adult canary (Serinus canaria) brain that plays a critical role in the acquisition and production of learned song. Recruitment of new neurons in the HVC is seasonally regulated and depends upon testosterone levels. We show here that brain-derived neurotrophic factor (BDNF) is present in the HVC of adult males but is not detectable in that of females, though the HVC of both sexes has BDNF receptors (TrkB). Testosterone treatment increases the levels of BDNF protein in the female HVC, and BDNF infused into the HVC of adult females triples the number of new neurons. Infusion of a neutralizing antibody to BDNF blocks the testosterone-induced increase in new neurons. Our results demonstrate that BDNF is involved in the regulation of neuronal replacement in the adult canary brain and suggest that the effects of testosterone are mediated through BDNF. (+info)
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Hypogonadism30
- Testosterone is used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). (medlineplus.gov)
- Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland, (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. (medlineplus.gov)
- Testosterone replacement therapy in men with low or no production of natural testosterone (hypogonadism). (netdoctor.co.uk)
- In fact, testosterone replacement therapies have only been approved by the FDA for the treatment of men who have been diagnosed with hypogonadism, an absence of serum testosterone that is detected by a blood test and that can result in a number of other health problems, according to court documents. (prweb.com)
- Currently, total-testosterone levels are used as a measure of testosterone deficiency or hypogonadism. (medscape.com)
- Obesity is a particularly common cause of low total testosterone but normal free testosterone and of misdiagnosis of hypogonadism," he explained in an email. (medscape.com)
- When total-testosterone levels are borderline [and] in situations where important variations of SHBG can be expected, total testosterone can lead to overdiagnosis of hypogonadism (such as in obese men, or men treated with glucocorticoids who have lower SHBG) or to underdiagnoses (eg, in older men or men with thyroid hyperfunction, situations with higher SHBG). (medscape.com)
- After the age of 40, many men are diagnosed with hypogonadism, a condition where the body does not produce enough testosterone. (medicalnewstoday.com)
- Testosterone is commonly prescribed in hypogonadism, as it can improve muscle strength and sex drive. (medicalnewstoday.com)
- Testosterone therapy is used to treat men with clinically diagnosed testosterone deficiency, also known as hypogonadism. (prnewswire.com)
- Fifty patients with late-onset hypogonadism and similarly sedentary lifestyles were enrolled and placed into one of two random groups prior to starting the 20-week study, which included 12 weeks of Testosterone Replacement Therapy ( TRT) and eight weeks of follow-up without therapy. (prnewswire.com)
- In particular, 72.2 percent of patients in the exercise group reported improvements in erectile function at the conclusion of the study, compared to 45.5 percent of the non-exercise group, leading researchers to conclude, the combination of exercise and TRT offers significant improvements in testosterone levels and late-onset hypogonadism symptoms, which can be well sustained with continuous exercise even after the cessation of TRT. (prnewswire.com)
- The agency demanded labels be revised make it clear the drugs are only for patients with diseases like hypogonadism or injuries that cause severely low levels of testosterone, and that replacement therapy may raise the risk of cardiovascular problems. (forbes.com)
- Some guidelines from medical organizations suggest that men whose blood tests indicate low levels of the hormone-and who cite common complaints of aging such as low energy and insomnia-may be candidates for testosterone, even if they don't fit the classical definition of hypogonadism, the authors say. (forbes.com)
- Testosterone undecanoate (Aveed) is a man-made version of the natural hormone, testosterone prescribed for low testosterone (low-t) in adult males with low or lack of testosterone due to primary hypogonadism. (medicinenet.com)
- Shabsigh R. Hypogonadism and erectile dysfunction: the role for testosterone therapy. (cmaj.ca)
- Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali , as testosterone booster for managing men with late-onset hypogonadism? (nih.gov)
- Low testosterone levels, or hypogonadism, in both men and women may cause any, or all, of these symptoms. (thebody.com)
- Recent research has also indicated that at least half of all men living with AIDS suffer from hypogonadism, and that as many as 33 to 66% of women also have lower than normal testosterone values. (thebody.com)
- Testosterone is recommended for men who make too little of the hormone on their own, a condition called hypogonadism. (reuters.com)
- Late-onset Hypogonadism and Testosterone Therapy - A Summary of Guidelines from the American Urological Association and the European Association of Urology. (nih.gov)
- Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality. (nih.gov)
- Important lessons about testosterone therapy - weight loss vs. testosterone therapy for symptom resolution, classical vs. functional hypogonadism, and shortterm vs. lifelong testosterone therapy . (nih.gov)
- Testosterone is used for the treatment of men whose bodies do not make enough natural testosterone, a condition called hypogonadism. (mayoclinic.org)
- Male hypogonadism is characterized by the failure to produce testosterone or a decrease in the production of testosterone. (healthcentral.com)
- Whereas testosterone inhibits the growth of muscle and body hair, men with hypogonadism may experience late puberty (or not at all). (healthcentral.com)
- The FDA has approved an inhalable formulation of testosterone (Natesto) to treat hypogonadism, according to drugmaker Trimel Pharmaceuticals. (medpagetoday.com)
- Thus, free testosterone measurement offers greater sensitivity than total testosterone for diagnosis of hypogonadism in older men. (questdiagnostics.com)
- Testosterone therapy may be recommended for adult males with symptomatic hypogonadism. (questdiagnostics.com)
- I understanding is that there is a condition ~ hypogonadism that affects testosterone production and is pituitary gland related. (healingwell.com)
Hormone76
- In 2003, the Institute of Medicine reported there was not enough evidence to support a beneficial effect of testosterone in men who have low levels of the hormone. (ufl.edu)
- Abuse of testosterone, a steroid hormone that helps athletes and bodybuilders bulk up, has been associated with cardiovascular disease, increased risk of heart attack, and mood changes, as well as prostate cancer. (go.com)
- Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. (medlineplus.gov)
- Testosterone has long been considered the hormone that makes men masculine. (abc.net.au)
- Overweight and obese men tend to have lower testosterone levels because excess belly fat converts testosterone to estrogen , another hormone. (webmd.com)
- Testosterone therapy is recommended for men whose blood levels of this masculine hormone fall below the normal range. (cnn.com)
- June 26, 2003 -- It's looking more and more like the male hormone testosterone may do for women what Viagra did for men. (webmd.com)
- There are currently no medications approved in the United States for the treatment of low libido in women, but many doctors already are prescribing androgens like testosterone or the chemically similar steroid hormone DHEA for this purpose. (webmd.com)
- Virormone injection contains the active ingredient testosterone propionate, which is an ester of the naturally occurring male hormone testosterone. (netdoctor.co.uk)
- Since testosterone is the main hormone responsible for the growth and development of the male sex organs and sexual characteristics, testosterone injections may also be given to treat delayed puberty in boys. (netdoctor.co.uk)
- The growth of some breast cancers is increased by the female hormone oestrogen and testosterone works by opposing the effects of the oestrogen. (netdoctor.co.uk)
- About 40 percent of total testosterone is tightly bound to sex hormone-binding globulin, or SHBG, meaning it's not readily available for use by the body. (menshealth.com)
- DUBLIN - Measuring free testosterone together with total testosterone may provide a more accurate picture than measuring total-testosterone levels alone when it comes to diagnosing deficiency of this male hormone, a new study indicates. (medscape.com)
- However, only free testosterone, unbound by sex-hormone-binding globulin (SHBG), can enter and activate androgen receptors in cells, resulting in testosterone-mediated effects, she explained. (medscape.com)
- To counter the negative effects of aging, many men seek androgen hormone replacement therapy , usually in the form of testosterone . (medicalnewstoday.com)
- Testosterone is the hormone that is responsible for masculine growth and development during puberty . (medicalnewstoday.com)
- Most testosterone is bound to sex hormone-binding globulin (SHBG) protein and isn't active. (healthline.com)
- ST. LOUIS -- Low levels of the male sex hormone, testosterone, in older men is associated with the onset of Alzheimer's disease, according to research by a team that includes a Saint Louis University scientist. (scienceblog.com)
- This observation has lead some physicians to wonder if low testosterone level may, in part, be responsible for the process of aging and whether testosterone replacement can serve as anti-aging hormone therapy. (everything2.com)
- Perls and Handelsman's critique of testosterone marketing comes just weeks after the U.S. Food & Drug Administration issued tough new rules for the companies that market the hormone treatment. (forbes.com)
- And they're urging the FDA and Health Canada to require physicians to demonstrate-with legitimate hormone testing and the like-that any patient handed a prescription for testosterone actually has a disease that needs to be treated. (forbes.com)
- But the FDA reports that a quarter of the men who received testosterone prescriptions never even had their hormone levels tested. (forbes.com)
- Testosterone is a medication and naturally occurring steroid hormone. (dbpedia.org)
- In a wide range of vertebrate species, there is a clear relationship between a male's aggressiveness and his circulating levels of androgen s such as testosterone , a hormone produced in the testes. (britannica.com)
- Finally, while a causal link between circulating testosterone levels and aggression has been well established, it is also clear that the link can work in the opposite direction, with participation in a fight having rapid effects on hormone secretion. (britannica.com)
- In particular, many vertebrates that win fights show increased testosterone levels, while losers exhibit not only reduced levels of testosterone but also elevated levels of the stress hormone cortisol . (britannica.com)
- Testosterone is a hormone that increases muscle mass, strength and hemoglobin - which affects endurance. (mercurynews.com)
- Dehydroepiandrosterone (DHEA) is a hormone that occurs in the body, and people can purchase it as a testosterone supplement. (medicalnewstoday.com)
- A testosterone test measures the blood level of the male sex hormone testosterone. (kidshealth.org)
- and follicle-stimulating hormone, or FSH) that work together to stimulate the testes to make testosterone. (kidshealth.org)
- Testosterone undecanoate is a long-acting man-made version of testosterone, the natural male sexual hormone. (medicinenet.com)
- Testosterone may be associated with aggression but a new research claims the male hormone also drives social behaviour and honest interactions. (hindustantimes.com)
- 2 This hormone clearly increases responsiveness to phosphodiesterase type 5 inhibitors, and testosterone levels correlate with measured frequency of sleep erections. (cmaj.ca)
- There is new evidence that varicoceles, long known to be a cause of male infertility, interfere with the production of testosterone -- a crucial hormone to maintaining men's health. (news-medical.net)
- Testosterone is a male sex hormone and is produced in the testes. (buzzle.com)
- Although women secrete testosterone in small amounts, deficiency of this hormone can gravely affect women. (buzzle.com)
- Testosterone is a hormone produced by the human body. (selfgrowth.com)
- Testosterone is a sex hormone made by the ovaries, and it seems to decline with age. (womansday.com)
- Testosterone is the primary androgenic/anabolic steroid hormone in the body of men and women. (thebody.com)
- Testicular atrophy, or shrinkage of the testicles, is fairly common, as supplementing the body with testosterone can shut down the body's own production of this hormone. (thebody.com)
- Testosterone is a steroid hormone from the androgen group. (news-medical.net)
- Testosterone is the principle male sex hormone and is responsible for reproductive growth and development in male vertebrates. (news-medical.net)
- A drug that lowers levels of the male hormone testosterone in the body reduces the risk of men with pedophilic disorder sexually abusing children, a study from Karolinska Institutet published today in the journal JAMA Psychiatry shows. (news-medical.net)
- TESTOSTERONE (tes TOS ter one) is the main male hormone. (nationwidechildrens.org)
- Now, it is important to note that in some cases there can be side effects from hormone therapy and it is important to talk to your doctor or nutritionist even if you are just starting a course of natural testosterone boosters. (infobarrel.com)
- I tried to be as clear as possible - testosterone is an absolutely vital hormone for women - but I'll try to be clearer. (marksdailyapple.com)
- Women (and men) may consider testosterone to be the masculine hormone, but they'd definitely notice if it suddenly went missing from their lives. (marksdailyapple.com)
- Testosterone is the male sex hormone responsible for the development of muscles, body hair and other male characteristics. (giantmicrobes.com)
- Some studies have found that the hormone can increase aggressive behavior, though recent studies, including one published Wednesday in the journal PLoS ONE , show that testosterone may encourage less selfish behavior in certain situations. (ibtimes.com)
- Falk speculates that testosterone is involved in pride, and an increase in the hormone may relate to a need to develop a positive sense of self. (ibtimes.com)
- As testosterone therapy becomes more widespread, a growing number of medical experts worry that it has become too easy for men to get the hormone-whether from their own physicians or stand-alone "low T" clinics-and that many users could be putting themselves at risk for worse conditions than those they are trying to counteract. (scientificamerican.com)
- Testosterone, as produced by the body, is a versatile hormone. (scientificamerican.com)
- Disease or injury in the testes or pituitary gland-a part of the brain that instructs the testes to produce testosterone-can hinder the body's ability to make the hormone. (scientificamerican.com)
- While the potential risks associated with taking supplemental testosterone-particularly in otherwise healthy men-are not well studied, concern has focused on whether extra amounts of the hormone might damage the prostate, heart or brain. (scientificamerican.com)
- Perhaps an extra dose of testosterone could be helpful for otherwise healthy men whose hormone levels had faded with age or because they were obese or suffered from diabetes? (scientificamerican.com)
- Testosterone is the male hormone, though it is a normal hormone in women as well. (wikihow.com)
- Testosterone, a steroid hormone associated with competition and dominance, is often viewed as an inhibitor of sociality, and may have antagonistic properties with oxytocin. (pnas.org)
- Testosterone is a male hormone responsible for the growth and development of male sex organs and maintenance of secondary sex characteristics. (mayoclinic.org)
- Today, doctors rely much less on hormone assay when deciding who and who should not be considered for testosterone supplementation. (selfgrowth.com)
- Testosterone is the predominant male sex hormone produced by the body. (healthcentral.com)
- An injury to the testes, which produces the hormone, can also cause low testosterone. (healthcentral.com)
- One of the goals of hormone therapy is to deprive the cancer of fuel by dramatically decreasing the amount of male hormones in the body, including testosterone. (healthcentral.com)
- In some cases, chemotherapy can damage the testes and can affect the levels of testosterone produced by the glands, leaving a man with a decreased amount of the hormone. (healthcentral.com)
- Although known as a male hormone, testosterone is essential for women and the review shows it may also reduce their concerns and their distress about sex. (afr.com)
- While testosterone can be given to women with or without hormone replacement therapy, the data showed it should not be given for issues such as fatigue, low mood or muscle strength. (afr.com)
- Robbie Williams, the singer, has disclosed that he habitually injects himself with the hormone testosterone to boost his sex drive. (telegraph.co.uk)
- Testosterone injections are generally prescribed for men whose bodies do not naturally make enough of the hormone. (telegraph.co.uk)
- It works by decreasing the quantity of Intercourse Hormone Binding Globulin (SHBG) in your blood which increases the quantity of free testosterone in your body. (dailystrength.org)
- It's not designed specifically for bodybuilders and athletes, however it offers significant benefits for health as nicely as a result of it comprises Tribulus Terrestris and will increase your Testosterone Hormone levels - however not as strongly as some of the other, extra powerful merchandise which can be obtainable. (dailystrength.org)
- Testosterone, is an important hormone for muscle building as well as wound healing and recovery, and it also contributes to motivation, feelings of well-being and libido. (livestrong.com)
- Testosterone is an anabolic/androgenic hormone. (exrx.net)
- Approximately 97 to 99 percent of testosterone is transported in the blood bound to plasma proteins such as sex hormone binding globulin (SHBG) and albumin. (exrx.net)
- If estrogen is the force behind female mojo, its male sexual partner is testosterone, the hormone that fuels guys' sex drive, fertility, mood, and even body type. (cosmopolitan.com)
- Testosterone is the hormone that powers your man's sex drive (and also plays a role in yours. (cosmopolitan.com)
- Testosterone is an important stimulator of sperm production, says Goodman, but even more important is FSH, the hormone that gets sperm to travel through the different stages, and LH. (cosmopolitan.com)
- Medical research has demonstrated that improving testosterone production, either naturally or through prescription hormone therapy, can drastically improve a man's functioning well into his 80s or longer. (infobarrel.com)
Rising testosterone levels2
- The improvement in desire seemed to correlate with rising testosterone levels. (webmd.com)
- In stags the neck muscles needed for effective roaring enlarge under the influence of rising testosterone levels. (britannica.com)
Levels192
- This report was the impetus for the TTrials, which are now the largest trials to examine the use of testosterone treatment in men 65 and older whose low testosterone levels can be attributed to age alone. (ufl.edu)
- The results of the TTrials show for the first time that testosterone treatment of older men who have unequivocally low testosterone levels does have some benefit," said Peter J. Snyder, M.D., the principal investigator of the TTrials and a professor in the division of endocrinology, diabetes and metabolism at the University of Pennsylvania's Perelman School of Medicine. (ufl.edu)
- Testosterone Replacement Therapy (TRT) is necessary only if Testosterone (T) levels are below normal. (earthlink.net)
- The Total or bound testosterone level (TT) and the Free Testosterone (FT). Free T levels can be detected by salivary testing. (earthlink.net)
- Q. What are some of the signs of low levels of Testosterone that I may feel? (earthlink.net)
- Conrad Swartz, 1987) Low testosterone levels increase the risk of both prostate cancer and severe heart disease (CAD or CHD). (earthlink.net)
- Very high blood levels of testosterone might protect against Coronary heart disease or CHD, especially in men over age 60. (earthlink.net)
- Maintaining Testosterone Levels Men can take testosterone boosters in the form of supplements. (slideshare.net)
- Low testosterone levels can take a toll on a mans performance. (slideshare.net)
- There are herbs that promote the increase of testosterone levels for men. (slideshare.net)
- Your physician can check your testosterone levels with a simple blood test. (diabetes.org)
- Lower testosterone levels have been shown to be an independent risk factor for worse outcomes among men and women with heart failure. (go.com)
- Low testosterone levels have been associated with decreased survival for men with coronary artery disease. (go.com)
- And, testosterone supplementation has been associated with better cholesterol levels among men with heart disease, Ezekowitz and his colleagues noted in their study. (go.com)
- The history provided suggests that, given the ongoing use of Estratest HS every other day, addition of the topical compounded testosterone produced systemic androgen levels that resulted in her alopecia. (medscape.com)
- Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to take testosterone. (medlineplus.gov)
- Testosterone replacement therapy (TRT) can bring your testosterone levels back to normal and restore your sex drive . (webmd.com)
- Your brain interprets this rise in testosterone levels as a sign that you now have enough testosterone. (webmd.com)
- At present, our testosterone levels are under siege. (huffingtonpost.com)
- One particularly disturbing study, published in the Journal of Clinical Endocrinology and Metabolism in 2007, indicated that men's testosterone levels plummeted 17 percent from 1987 to 2004-and that's controlling for health and lifestyle factors, such as obesity and diabetes, that are known to affect T levels. (huffingtonpost.com)
- Testosterone therapy, when used by men over age 65 who have low testosterone levels, offers some health benefits but also poses potential risks, suggests a roundup of five new studies in the Journal of American Medicine and JAMA Internal Medicine. (cnn.com)
- The Testosterone Trials included 788 men who were 65 years or older and had low blood levels of testosterone. (cnn.com)
- Investigators found that boosting testosterone levels was associated with increased sexual desire in women who complained of menopause -related low libido and reduced sexual arousal. (webmd.com)
- Testosterone levels were measured at the beginning and end of treatment, and all women completed questionnaires designed to measure their sexual interest. (webmd.com)
- By week eight, the testosterone-treated patients had measurable improvements in testosterone levels that put them in the upper normal range, and they reported improved interest in sex . (webmd.com)
- New research from Australia confirms that testosterone levels drop in women well before they reach menopause . (webmd.com)
- The cause of low desire isn't always medical, but it turns out that a large percentage of women with this problem have blood tests that are consistent with low levels of testosterone and other androgens," he says. (webmd.com)
- Low levels of testosterone can cause decreased sex drive, impotence , infertility due to decreased sperm production, decreased mental and physical activity, fatigue and weakening of bones ( osteoporosis ). (netdoctor.co.uk)
- Testosterone is given as replacement therapy when natural testosterone levels fall too low, causing problems such as those above. (netdoctor.co.uk)
- Natural testosterone levels fall slowly with age and fall rapidly following surgical removal of the testicles (for example in the treatment of testicular cancer ). (netdoctor.co.uk)
- Testosterone replacement allows natural testosterone levels to return to normal, thus relieving the symptoms of the deficiency. (netdoctor.co.uk)
- The injection is usually given two to three times a week to treat low testosterone levels and once a week to treat delayed puberty. (netdoctor.co.uk)
- The exact frequency may depend on your individual testosterone levels. (netdoctor.co.uk)
- Men being treated for low testosterone levels will need to have blood tests to measure your blood level of testosterone before starting and regularly throughout treatment with this medicine. (netdoctor.co.uk)
- Tell your doctor if you experience symptoms such as frequent or persistent erections, irritability, nervousness or weight gain after starting treatment with this medicine, as these suggest your testosterone levels are too high and your dose may need adjusting. (netdoctor.co.uk)
- Men being treated for low testosterone levels will also need to have regular blood tests to monitor their red blood cells, liver function and prostate specific antigen (PSA) levels. (netdoctor.co.uk)
- Most men can expect their testosterone levels to drop by about 1 percent a year beginning in their 50s. (menshealth.com)
- No one was suggesting that men rush out to get their testosterone levels checked (though, okay, I did), much less consider testosterone therapy (and, yes, I am considering it). (menshealth.com)
- Testosterone levels typically increase to ready us for a challenge, whether it's a football game or a chess match. (menshealth.com)
- I think it would be preferable to use free testosterone rather than total testosterone to measure deficiency, especially in men who have borderline total-testosterone levels. (medscape.com)
- Older men, and young men with established heart disease, who got prescriptions to increase their levels of testosterone were more likely to have heart attacks in the weeks after getting the medication than were men who did not receive such prescriptions, a study has found. (chicagotribune.com)
- Testosterone levels naturally decrease with age. (medicalnewstoday.com)
- Competition against strangers or enemies-but not friends-can boost your testosterone levels if you come out on top , says a new study in Human Nature . (menshealth.com)
- A popular belief is that bald men have high levels of testosterone, but is this really true? (healthline.com)
- One of them is that men with MPB are more virile and have higher levels of testosterone. (healthline.com)
- Men with MPB may actually have lower circulating levels of testosterone but higher levels of the enzyme that converts testosterone to DHT. (healthline.com)
- Although women have much lower levels of testosterone than men do, there is enough to potentially cause androgenetic hair loss. (healthline.com)
- Who Has Low Testosterone Levels? (everything2.com)
- Depending on at what point testosterone levels are described as undesirably low, between 4 and more than 40 million men in North America alone suffer from this problem. (everything2.com)
- While medical science has determined that while a man's total (protein-bound) testosterone levels remain relatively stable over time, his bio-available (free) levels gradually decline at an alarming rate of two percent each year beginning at age thirty. (everything2.com)
- Having a low blood insulin level helps to prevent such attacks, and it is the men with the highest testosterone levels who have the highest insulin levels, although the correlation between these facts is not known. (everything2.com)
- As men age from 50 to 70, their testosterone levels drop more than 40%, causing them to become fatter, and less sexual, muscular and assertive, and have smaller, weaker bones. (everything2.com)
- My testosterone levels aren't going up while using Axiron, any thoughts? (drugs.com)
- Researchers found that men with higher testosterone levels were more likely to jump back into the game even after they lost. (wired.com)
- At the end of the study period, 81 percent of non-obese men had achieved normal testosterone levels, compared to 52 percent of obese men (P=0.03). (prnewswire.com)
- Total testosterone levels were 81 percent and 54 percent, respectively, suggesting that metabolic conditions may impact the efficacy of TRT. (prnewswire.com)
- It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful. (dbpedia.org)
- From fish to mammals, aggression levels rise and fall with natural fluctuations in testosterone levels. (britannica.com)
- CAPE TOWN, May 1 (Reuters) - An appeal by Olympic 800-meters champion Caster Semenya was dismissed Wednesday in a case involving regulations to restrict testosterone levels in female athletes. (mercurynews.com)
- Under the rules, female athletes who have high natural levels of testosterone will have to reduce their levels through medication to under 5 nmol/L. The normal female level is 2 nmol/L. (mercurynews.com)
- But the governing body has also come in for criticism from human rights organizations over its wish to medically alter naturally produced levels of testosterone, with the United Nations Human Rights Council adopting a resolution in support of Semenya in March. (mercurynews.com)
- Various supplements and medications may help increase a person's testosterone levels. (medicalnewstoday.com)
- Some people choose to increase their testosterone levels by using alternative treatments, though many of these lack scientific-backing. (medicalnewstoday.com)
- According to a study in the International Journal of Reproductive BioMedicine , D-Aspartic acid increases testosterone levels in some animals. (medicalnewstoday.com)
- In young boys, testosterone levels are normally low. (kidshealth.org)
- For example, low levels of testosterone can be due to a problem with the testes' production of testosterone or to the pituitary gland not making enough of the hormones that stimulate the testes to produce testosterone. (kidshealth.org)
- In teens and adults, testosterone levels can help doctors evaluate fertility or menstrual problems and sexual function. (kidshealth.org)
- The doctor may want to perform the test in the morning, when testosterone levels usually are highest. (kidshealth.org)
- Testosterone should be used cautiously with warfarin ( Coumadin ) because testosterone can reduce breakdown of warfarin, leading to increased warfarin blood levels and bleeding risk. (medicinenet.com)
- Men with the highest testosterone levels were more assertive, controlled the conversation, and clicked better with women. (hindustantimes.com)
- Sept. 5, 2014 -- Treating addiction to heroin and other opioid drugs with methadone can dramatically lower testosterone levels, but only in men, new research suggests. (medicinenet.com)
- Doctors should be aware of these findings and should manage symptoms of low testosterone , she said, including checking levels before and during methadone therapy. (medicinenet.com)
- Their more tender feelings literally "blunted" by elevated testosterone levels, they tend not to be particularly concerned about--or, for that matter, interested in--the feelings of others. (psychologytoday.com)
- Sadly, there's seems to be something about high testosterone levels that contributes to an almost predatory frame of mind, at least for those not reared very caringly in childhood . (psychologytoday.com)
- As one study has noted, "those with higher levels of testosterone are more inclined to smoke, drink alcohol excessively and indulge in risky behavior that leads to injury. (psychologytoday.com)
- However, testosterone levels do not directly correlate with erectile function, and supplementing low levels of testosterone in hypogonadal men or administering exogenous testosterone to eugonadal men generally does not enhance erectile performance. (cmaj.ca)
- You shouldn't be surprised as these are all common symptoms of low testosterone and with every passing year your testosterone levels drop significantly. (audible.com)
- There's a lot of confusion out in the media - and public in general - about low levels of testosterone. (audible.com)
- The fact is that low levels of testosterone is a treatable condition. (audible.com)
- Low testosterone levels are associated with low libido in both men and women . (healthline.com)
- High levels of dihydrotestosterone are associated with hair loss , while high levels of testosterone are associated with hair growth. (healthline.com)
- There is good news too: Microsurgery can increase testosterone levels in these men. (news-medical.net)
- In the current study, Dr. Goldstein and his colleagues measured the preoperative testosterone levels of 325 men with varicoceles and in 510 men without varicoceles. (news-medical.net)
- They found that men at every age with varicoceles had significantly lower testosterone levels (416 vs. 469 ng/dL) than the comparison group. (news-medical.net)
- After undergoing microsurgical varicocelectomy, testosterone levels significantly increased in 70 percent of the patients, with a mean increase of 178 ng/dL. (news-medical.net)
- It is observed that sexual performance dips in both men and women during low testosterone levels. (buzzle.com)
- Sexual dysfunction, low sex drive and dissatisfaction after sexual activity are some of the common complaints in women that arise due to inadequate testosterone levels. (buzzle.com)
- To be precise, these are hormonal disturbances that increases estrogen levels but slows down testosterone production. (buzzle.com)
- Low testosterone levels can show a range of symptoms. (buzzle.com)
- There are two types of herbal supplements that are effective in increasing the levels of testosterone in women. (buzzle.com)
- However, the non-estrogenic herbs are considered the best alternative for improving low testosterone levels. (buzzle.com)
- This non estrogenic herb helps to regulate the endocrine system, which in turn contributes to correct abnormal testosterone levels in the body. (buzzle.com)
- Another popular testosterone supplement that is beneficial for increasing testosterone levels, is testarol. (buzzle.com)
- It contains natural ingredients like Tribulus Terrestris and Beta-ecdysterone, that elevate testosterone levels and enhance physical performance. (buzzle.com)
- Diminishing female libido or one can say impotency in women can be treated successfully with testarol due to its ability to elevate testosterone levels as found out through clinical studies. (buzzle.com)
- Tribulus Terrestris is a herbal supplement, also used to raise testosterone levels in women. (buzzle.com)
- Low testosterone, or low T, is diagnosed when levels fall below 300 nanograms per deciliter (ng/dL). (selfgrowth.com)
- When testosterone levels are too low, a man may have difficulty achieving an erection prior to sex or having spontaneous erections (for example, during sleep). (selfgrowth.com)
- Both testosterone levels and cognitive functions - particularly memory - decline with age. (selfgrowth.com)
- According to a research study published in the Journal of the American Medical AssociationTrusted Source , some smaller research studies have linked testosterone supplementation with improved memory in men with low levels. (selfgrowth.com)
- However, the study's authors did not observe memory improvements in their study of 493 men with low testosterone levels who took testosterone or a placebo. (selfgrowth.com)
- Research over the last few years has shown the importance of monitoring testosterone levels in both men and women. (thebody.com)
- What are considered 'normal levels' of testosterone vary from individual to individual, and thus are a source of frustration for many people living with HIV. (thebody.com)
- of total testosterone levels for men, and 50 to 100 ng. (thebody.com)
- of total testosterone levels for women. (thebody.com)
- In other words, right after your injection, your testosterone levels are very high, and then they decrease through the time until your next injection. (thebody.com)
- I'm also curious to know how much levels of testosterone and estrogen need to decrease or increase in order to cause side effects. (americanscientist.org)
- In contrast, when testosterone is administered at constantly high doses (equivalent to male levels), it can have major masculinizing effects: It can lead to baldness, can cause the pitch of one's voice to deepen, and may increase the risk of cardiovascular diseases-all features of males. (americanscientist.org)
- Researchers found a one-hour mindful yoga class, done three times a week, reduced testosterone levels by 29% over a three-month period. (news-medical.net)
- Men with erectile dysfunction have a higher risk of death, regardless of their testosterone levels, suggests a study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society. (news-medical.net)
- Men appear to be biologically wired to care for their babies, say researchers who have discovered levels of testosterone go down after fatherhood. (bbc.co.uk)
- Men with newborn babies less than a month old had especially reduced levels of testosterone. (bbc.co.uk)
- And the researchers believe lower testosterone levels might protect against certain chronic diseases, which could, in part, explain why married men and fathers often enjoy better health than single men of the same age. (bbc.co.uk)
- Testosterone levels in men generally don't change that much. (bbc.co.uk)
- The observations could make some evolutionary sense if we accept the idea that men with lower testosterone levels are more likely to be monogamous with their partner and care for children. (bbc.co.uk)
- However, it would be important to check that link between testosterone levels and behaviour before we could be certain. (bbc.co.uk)
- But advertising campaigns for testosterone products may be reaching a bigger pool of men - who are tired or depressed, for instance, but don't have clinically low testosterone levels. (reuters.com)
- The researchers collected information on about 8,700 men seen at Veterans Affairs hospitals who had low testosterone levels. (reuters.com)
- This medicine is used in males to treat low testosterone levels. (nationwidechildrens.org)
- The best thing, as reported by the men who use them, about testosterone boosters is that they eliminate the symptoms of low testosterone by replacing the testosterone in the body to its optimum levels. (infobarrel.com)
- However, improved sexual performance is one of the main benefits of increased testosterone levels. (infobarrel.com)
- In fact, there are so many men who are pleased with the results of increasing testosterone levels that a number of websites and blogs have sprung up to discuss various testosterone boosting therapies and what men have found to be successful. (infobarrel.com)
- This medicine is only approved for use in men who have low levels of testosterone related to certain medical conditions. (nationwidechildrens.org)
- After age 30, most men will encounter a gradual decline in testosterone levels. (giantmicrobes.com)
- Abnormally high testosterone levels in men typically occur in athletes who use it to grow muscle and boost performance. (giantmicrobes.com)
- Testosterone may not rev up men's sex lives as much as they expect it to: Older men with slightly low testosterone levels did not experience improvement in their desire or intimacy after they took testosterone supplements, according to a new study. (livescience.com)
- The findings agree with previous research that found that men with testosterone levels at the lower end of the normal range don't see improvements in sexual function after taking testosterone supplements. (livescience.com)
- When testosterone levels dip too low, men can become depressed and lethargic, lose interest in sex, and lose some of their muscle and body hair. (scientificamerican.com)
- It is unclear precisely why testosterone levels decline for certain individuals in these situations. (scientificamerican.com)
- If you are worried about your testosterone levels, there are ways you can check them. (wikihow.com)
- If your testosterone levels are low, talk to your physician about testosterone replacement therapy. (wikihow.com)
- Testosterone levels vary in different men, so it can be difficult to determine if the levels detected in one man are too low. (wikihow.com)
- Through this research they have been able to connect the dots between certain health conditions and the low testosterone levels. (feedburner.com)
- Ageless Men's Health has been dedicated to assisting men with low testosterone levels since opening our first clinic in 2007. (feedburner.com)
- Your doctor will test the testosterone levels in your blood before you start and while you are using this medicine. (mayoclinic.org)
- A recent study suggests men's testosterone levels are significantly affected by their health and lifestyle choices. (psychcentral.com)
- Testosterone levels reduce by about one percent a year in men over 40. (psychcentral.com)
- Co-morbidities and lifestyle influences may be as strongly associated with declining testosterone levels as is aging itself over the short- to mid-term. (psychcentral.com)
- Low testosterone levels may contribute to myriad health conditions, including diabetes, osteoporosis and impaired sexual function. (psychcentral.com)
- He found that, overall, lower levels of testosterone in healthy older men are linked to poorer performance on cognitive tests. (psychcentral.com)
- He recommended measuring testosterone levels in older men who show signs of cognitive impairment, and that supplementation be considered if levels are low. (psychcentral.com)
- There is no evidence that raised testosterone levels causes or increases the risk of prostate cancer. (selfgrowth.com)
- Prostate cancer is a disease of older men with reduces testosterone levels. (selfgrowth.com)
- It is not a disease of younger men with high testosterone levels. (selfgrowth.com)
- Does this not therefore strongly suggest that the increase of testosterone levels would have the opposite effect and increase the incidence of prostate cancer? (selfgrowth.com)
- As men age, testosterone levels naturally go down. (healthcentral.com)
- Testosterone helps build muscle in men and when testosterone levels decrease, muscle mass decreases and fat deposits begin to accumulate. (healthcentral.com)
- Low testosterone levels in men can also lead to decreased sexual drive, low sperm count and problems with erections. (healthcentral.com)
- By the end of the study, 90% of men on the drug had testosterone levels within the normal range, the company said Wednesday in a press release. (medpagetoday.com)
- Women naturally have low levels of testosterone. (afr.com)
- Caster Semenya lost her appeal Wednesday against rules designed to decrease naturally high testosterone levels in some female runners. (usatoday.com)
- A panel of three judges denied Semenya's appeal against IAAF rules that will force female runners to decrease naturally high testosterone levels. (usatoday.com)
- Semenya, a two-time Olympic champion in the 800 meters, will now be forced to medicate to suppress her testosterone levels if she wants to defend her world title in September in Doha, Qatar. (usatoday.com)
- Caster Semenya lost her appeal against IAAF rules to curb female runners' high natural levels of testosterone. (usatoday.com)
- The IAAF went into the case with the scientific argument that female runners with high testosterone levels have an unfair advantage in events from 400 meters to the mile. (usatoday.com)
- These men usually have low serum testosterone levels and gonadotropins (FSH, LH) above the normal range. (nih.gov)
- These men have low testosterone serum levels but have gonadotropins in the normal or low range. (nih.gov)
- To ensure proper dosing, serum testosterone levels should be measured at intervals and replaced to serum testosterone levels in the normal range. (nih.gov)
- By potentially playing a role in maintaining a healthy weight, celery might also help men maintain healthy testosterone levels. (livestrong.com)
- Being at a healthy weight helps men maintain ideal testosterone levels. (livestrong.com)
- In contrast, having excess body fat can cause a drop in a man's testosterone levels. (livestrong.com)
- However, because this research was conducted on rats and no human studies support this effect, you should not rely on your vitamin K intake to boost testosterone levels. (livestrong.com)
- Backside Line: Taking zinc may be efficient in those with low zinc or testosterone levels, or those who are currently in hectic coaching. (dailystrength.org)
- So in case you have regular testosterone levels, boosting above your pure base stage could at greatest provide you with a few hours whereas your body makes, and then immediately processes out, the excess testosterone. (dailystrength.org)
- This could increase overall circulating testosterone, especially in those with low baseline testosterone levels three. (dailystrength.org)
- Proven methods to increase testosterone levels naturally. (dailystrength.org)
- Far too many men fully overlook the position that testosterone performs in their general nicely-being, but when your levels are not optimized, make no mistake about it, you will really feel the effects. (dailystrength.org)
- Exercise of even moderate intensity can promote muscle protein breakdown, and if your testosterone levels are low because you are consuming a low-fat diet, your ability to recover from exercise training will be compromised. (livestrong.com)
- Testosterone levels are not just a marker of your ability to build muscle, but your ability to maintain lower body fat levels as well. (livestrong.com)
- A study published in 2000 in the "The Journal of Clinical Endocrinology and Metabolism" showed that low testosterone levels correlated with an increase in body fat levels. (livestrong.com)
- In a 2009 study in the "European Journal of Endocrinology," researchers showed that low testosterone levels were a primary contributor to a decrease in bone mineral density in postmenopausal women. (livestrong.com)
- Thus, bioavailable testosterone levels depend on albumin levels to a small extent (low binding affinity) and SHBG levels to a large extent (high binding affinity) in addition to rates of testosterone production and clearance. (questdiagnostics.com)
- Total testosterone levels can range from absent to increased, depending on the condition. (questdiagnostics.com)
- As men age, testosterone levels decrease, SHBG levels increase, and these changes result in a decrease in free testosterone levels. (questdiagnostics.com)
- 9 To assess when levels reach the mid-normal range, guidelines recommend monitoring total testosterone in hypogonadal males during treatment. (questdiagnostics.com)
- Free testosterone levels are elevated in about 70% of PCOS cases. (questdiagnostics.com)
- Direct immunoassays cannot accurately measure the low serum testosterone levels found in women and children, 10 and hypogonadal men. (questdiagnostics.com)
- As for me, I have to live with my testosterone levels of less than 50. (healingwell.com)
- A decline in testosterone levels as men grow older is likely the result-not the cause-of deteriorating general health, say Australian scientists, whose new study finds that age, in itself, has no effect on testosterone level in healthy older men. (exrx.net)
- We often hear information about raising testosterone levels, but some people would like to lower testosterone levels. (ehow.co.uk)
- Having high testosterone levels can sometimes explain hair loss. (ehow.co.uk)
- You may have other reasons you need to lower testosterone levels, but you should make sure that it's the right step and only do so with a doctor's recommendation. (ehow.co.uk)
- According to Dr. Kaayla T. Daniel, soy protein lowers testosterone levels in men. (ehow.co.uk)
- Nuts and beans naturally enhance testosterone levels, so staying away from these types of foods is wise when trying to reduce testosterone levels. (ehow.co.uk)
- Liquorice root is available in supplement form and is very effective in lowering testosterone levels. (ehow.co.uk)
- Other natural testosterone reducers include marijuana and tobacco, but again, these are highly advised against and some of the health ramifications of using such products are worse than having higher testosterone levels. (ehow.co.uk)
- Testosterone levels have been linked to aggressive behavior in animals and humans (Bahrke, Barke, & Strauss, 1990). (exrx.net)
- In high levels, dihydrotestosterone can assume the function of testosterone, and testosterone can assume the function of dihydrotestosterone (Di Pasquale, 1992a). (exrx.net)
- The increase in SHBG likely results in a further decline in testosterone levels. (exrx.net)
- I would like to discuss some of the ways that a man can increase his testosterone levels naturally without having to see a doctor. (infobarrel.com)
- Natural testosterone replacement is becoming more popular as a less expensive, non-prescription method to increase testosterone levels safely and without risk of major side effects. (infobarrel.com)
- Testosterone undecanoate, sold under the brand names Nebido, Aveed, and Andriol among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. (wikipedia.org)
Effects of testosterone12
- Despite interest in novel ways to improve exercise function in heart failure, "we should not yet view testosterone as the definitive answer," Yancy said, noting the lack of information about long-term cardiovascular effects of testosterone treatments. (go.com)
- The studies were a response to the Institute of Medicine's call in 2003 for more rigorous study of the positive and negative health effects of testosterone replacement therapy in older men. (cnn.com)
- Exercise may help sustain the positive effects of testosterone therapy even after treatment ends, according to a new study from Ansan Hospital and Seoul Paik Hospital in Korea. (prnewswire.com)
- The hormones also have a lasting effect on the development of the brain structures that control aggression in adult animals, making the structures more sensitive to the aggression-facilitating effects of testosterone. (britannica.com)
- What are the side effects of testosterone undecanoate-oral capsule? (medicinenet.com)
- Metabolic Effects of Testosterone Therapy in Men with Type 2 Diabetes and Metabolic Syndrome. (nih.gov)
- Effects of testosterone therapy for women: a systematic review and meta-analysis protocol. (nih.gov)
- Appropriate studies have not been performed on the relationship of age to the effects of testosterone in the pediatric population. (mayoclinic.org)
- But he added that large, long-term studies on the effects of testosterone supplements for cognitive function are still needed. (psychcentral.com)
- Professor Davis, director of the Women's Health Research Program at Monash, has been investigating the effects of testosterone since the early '90s. (afr.com)
- Side effects of testosterone undecanoate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. (wikipedia.org)
- Side effects of testosterone undecanoate include virilization among others. (wikipedia.org)
Androgen9
- Testosterone phenylpropionate ( BAN ) (brand name Testolent ), or testosterone phenpropionate , also known as testosterone hydrocinnamate , is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester - specifically, the C17β phenyl propionate ester of testosterone - which was formerly marketed in Romania . (wikipedia.org)
- Testosterone is known as an androgen. (netdoctor.co.uk)
- Testosterone, however, is not the main androgen (hormones that promote male characteristics) in women. (americanscientist.org)
- Testosterone is a type of androgen, also known as a steroid. (giantmicrobes.com)
- Measurement of free or bioavailable testosterone in females offers greater sensitivity for evaluation of mild androgen excess than total testosterone. (questdiagnostics.com)
- Testosterone hexahydrobenzylcarbonate (brand name Lontanyl), or testosterone cyclohexylmethylcarbonate, is an androgen and anabolic steroid and a testosterone ester. (wikipedia.org)
- The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). (wikipedia.org)
- Testosterone undecanoate is used in androgen replacement therapy. (wikipedia.org)
- citation needed] Testosterone undecanoate is a prodrug of testosterone and is an androgen and anabolic-androgenic steroid (AAS). (wikipedia.org)
Amount of testosterone8
- Aside from enhancing the amount of testosterone in the body, these boosters help in building muscles. (slideshare.net)
- There are several treatment options available such as gels, patches or injections that increase the amount of testosterone in your body. (diabetes.org)
- Your doctor may adjust your dose of testosterone depending on the amount of testosterone in your blood during your treatment and your reaction to the medication. (medlineplus.gov)
- Your doctor may adjust your dose of testosterone depending on the amount of testosterone in your blood during your treatment. (medlineplus.gov)
- This treatment method is popular as it is easy to administer, and the amount of testosterone a person receives is consistent each day. (medicalnewstoday.com)
- This supplement is a combination of vitamins and minerals that increase the amount of testosterone produced naturally by the body. (buzzle.com)
- Both men and women need the proper amount of testosterone to develop and function normally. (giantmicrobes.com)
- This process occurs when the amount of testosterone in the body decreases and production slows. (healthcentral.com)
Supplementation6
- the rate of testosterone supplementation has nearly quadrupled in the United States. (medscape.com)
- Numerous studies have also shown that many PWAs suffering from wasting are hypogonadyl and that testosterone supplementation has resulted in gains in lean body and muscle mass, as well as improvements in quality of life and overall well-being. (thebody.com)
- As with any other drug therapy, there can be side effects from testosterone supplementation. (thebody.com)
- Still, the findings are not the final world on the safety of testosterone supplementation. (livescience.com)
- Often, a man with low testosterone as a product of one of these treatments will also be given a prescription for testosterone supplementation. (healthcentral.com)
- post an article a few months ago about a study on testosterone supplementation and exercise in elderly men? (exrx.net)
Therapy38
- Q. What is Testosterone replacement therapy? (earthlink.net)
- Q. Is testosterone replacement therapy safe? (earthlink.net)
- The observed improvements need to be reproduced in larger numbers of patients before testosterone can be recommended as therapy, said Dr. Justin Z. Ezekowitz , director of the Heart Function Clinic at the University of Alberta in Edmonton, Canada. (go.com)
- Her libido was restored with perineal testosterone , but the topical therapy was abandoned because of excessive scalp hair loss. (medscape.com)
- Testosterone replacement therapy has a profound impact on a man's reproductive potential," says urologist Michael Eisenberg, MD. He's director of male reproductive medicine and surgery at Stanford Hospital and Clinics in Palo Alto, Calif. (webmd.com)
- When you're getting testosterone replacement therapy, testosterone is added into the bloodstream by patches, gels, or other treatment methods. (webmd.com)
- A separate study separate study, published in JAMA Internal Medicine, also showed that testosterone therapy is associated with a lower risk of cardiovascular events in men 40 or older over a period of about three years. (cnn.com)
- While he is excited about the potential of testosterone therapy, Goldstein agrees that it is not a cure-all for all women who have no interest in sex . (webmd.com)
- There is concern that, under current clinical guidelines, some men are misdiagnosed with testosterone deficiency and receive inappropriate therapy, while others who should get treatment don't receive it, Dr Leen Antonio (University of Leuven, Belgium) explained when presenting her research here at the European Congress of Endocrinology (ECE) 2015 . (medscape.com)
- Such treatment remains controversial, as concern has emerged about the potential for cardiovascular side effects with the use of testosterone therapy, particularly in older men. (medscape.com)
- The prescription of testosterone replacement therapy has increased dramatically in the last decade, with more and more men aged 40 and older trying to avoid the hormonal effects of aging. (medicalnewstoday.com)
- An increasing number of men have been seeking the treatment, with studies showing that the number of testosterone therapy prescriptions in the first decade of this century has nearly tripled . (medicalnewstoday.com)
- The news emerging about Testosterone Replacement Therapy (TRT) keeps getting be. (medhelp.org)
- ORLANDO, Fla. , May 18, 2014 /PRNewswire-USNewswire/ -- Three new studies examining the predictors, effects and durability of testosterone therapy on men will be presented to reporters at the 109th Annual Scientific Meeting of the American Urological Association (AUA) during a special press conference in the Orange County Convention Center, Orlando, FL on Sunday, May 18 at 2:00 p.m. (prnewswire.com)
- Men with these symptoms should consult with their physicians and undergo blood tests prior to starting testosterone replacement therapy. (prnewswire.com)
- 12nmol/L), researchers examined 164 men for five years of testosterone therapy. (prnewswire.com)
- Other potential downsides of testosterone therapy can include acne, liver inflammation and even aggressive personality changes. (womansday.com)
- A growing body of literature on effects of hormones in women and female-to-male transsexuals indicates that testosterone therapy can enhance to some extent aspects of sexual function (for example, libido and vaginal lubrication), improve memory, strengthen bone, reduce fat mass, and increase lean body mass. (americanscientist.org)
- It does kind of raise the question of, maybe when patients and their physicians are thinking about starting testosterone therapy, potential risks such as the ones we looked at should be in that discussion," said Dr. P. Michael Ho. (reuters.com)
- I think (taking testosterone) is an individual decision, but I think it's worth weighing the potential benefits of testosterone therapy versus any potential risks before starting it," Ho told Reuters Health. (reuters.com)
- Some men report that after beginning testosterone therapy that they have trained for and completed weight lifting competitions and marathons. (infobarrel.com)
- Although there has been some concern among health professionals that testosterone therapy might increase men's risk of heart disease , the study found no difference between the groups in measures of atherosclerosis progression. (livescience.com)
- Originally intended for men who have difficulty producing sex hormones because of damage or disease in their testes or other parts of the endocrine system, testosterone replacement therapy has become increasingly popular with middle-aged and older men who do not have clear deficits but who nonetheless hope to lessen some of the symptoms of aging, including fatigue, muscle wasting and lack of sex drive. (scientificamerican.com)
- As long as testosterone therapy was available only by injection, its use was largely limited to individuals with testicular injuries or other severe ailments. (scientificamerican.com)
- Greater ease of use also led to an expansion in the number of conditions for which doctors considered testosterone therapy to be a plausible treatment in spite of any supportive data. (scientificamerican.com)
- Choose a testosterone replacement therapy. (wikihow.com)
- Testosterone therapy in men with testosterone deficiency: Are we beyond the point of no return? (nih.gov)
- Benefits and Health Implications of Testosterone Therapy in Men With Testosterone Deficiency. (nih.gov)
- Testosterone therapy for transgender men . (nih.gov)
- Testosterone replacement therapy is associated with an increased risk of urolithiasis. (nih.gov)
- Understanding Doctors Hostility to Testosterone Replacement Therapy. (selfgrowth.com)
- Traditionally, doctors resistant to the notion that testosterone replacement therapy might be good for one, used to cite the lack of scientific evidence to support their negative views. (selfgrowth.com)
- Does testosterone therapy cause prostate cancer? (selfgrowth.com)
- The FDA is currently investigating the safety of testosterone as some studies have turned up a potential link between heart disease and the therapy. (medpagetoday.com)
- While previous research has suggested testosterone therapy can improve sexual function in women, the problem has been that all available formulations have been designed for men in doses several-fold greater than required by women. (afr.com)
- The prescription drug safety center DrugRisk.com is announcing new information on the site for patients using testosterone replacement therapy drugs. (prweb.com)
- If the serum testosterone concentration consistently exceeds the normal range at a daily dose of 5 g, AndroGel therapy should be discontinued. (nih.gov)
- Testosterone replacement therapy can improve erectile function for hypogonadal men. (exrx.net)
Natural Testosterone14
- Natural testosterone has actually been shown to lower the 'bad cholesterols' and decrease clotting of the blood. (earthlink.net)
- Natural testosterone supplements for women help relieve symptoms associated with testosterone deficiency. (buzzle.com)
- In such circumstances taking natural supplements that act as natural testosterone enhancers would be an effective way to restore sexual health in women. (buzzle.com)
- Natural testosterone supplements for women are a unique way to eliminate these symptoms. (buzzle.com)
- ZMA, a natural testosterone supplement often prescribed by practitioners, contains zinc, magnesium aspartate and vitamin B6. (buzzle.com)
- Therefore, if you are considering boosting your testosterone either by using a natural testosterone supplement or by visiting your doctor for testosterone injections or creams, you should look online to get a feel for what products are working for other men. (infobarrel.com)
- For this reason many men are looking for answers regarding natural testosterone replacement in order to get back to where they feel that they need to be. (infobarrel.com)
- Obviously, this means that some men will never realize the problem, get on natural testosterone boosters and improve their lives. (infobarrel.com)
- The good news is that natural testosterone replacement is not difficult to attain. (infobarrel.com)
- If after two months, it takes natural testosterone supplements some time to build up in the system, you are still suffering from these low testosterone symptoms then your problem may not actually be a lack of testosterone or you may have a problem requiring medical attention. (infobarrel.com)
- The best advice is to begin taking natural testosterone boosters as the primary element of natural testosterone replacement protocol. (infobarrel.com)
- You can buy two months worth of the best natural testosterone boosters for less than $100 at any number of herbal supplement websites or health food stores. (infobarrel.com)
- The most important thing to realize is that natural testosterone replacement is highly effective in treating symptoms that fifty years were thought of as simply a part of the aging process. (infobarrel.com)
- I would recommend that a person interested in natural testosterone replacement spend a couple of hours doing research, but I wouldn't recommend an extensive campaign. (infobarrel.com)
Estrogen15
- Women have estrogen hormones which make them different from men while men have testosterone hormones. (slideshare.net)
- If she chooses additional testosterone, is more estrogen indicated? (medscape.com)
- Women taking a low-dose estrogen -testosterone combination treatment reported a two-fold improvement in sexual interest, compared with women treated with estrogen alone. (webmd.com)
- Half the women were treated for 16 weeks with the low-dose oral estrogen-testosterone combination drug Estratest HS, and the others took a similar dose of estrogen alone. (webmd.com)
- Columbia University ob-gyn Rogerio A. Lobo, MD, who led the study team, says the results confirm that testosterone is an effective treatment for lack of sexual desire in postmenopausal women who do not respond to estrogen alone and whose libido problems are not caused by depression . (webmd.com)
- This effect is believed to occur due to an imbalance between testosterone and estrogen within men. (selfgrowth.com)
- However, as noted in our American Scientist article, some of these effects may be due to estrogen produced by the aromatization of their testosterone. (americanscientist.org)
- Ms. Fortin's last question relates to how much change in testosterone or estrogen is needed to cause side effects. (americanscientist.org)
- We have the notion that estrogen and testosterone are mortal enemies, waging bitter hormonal war as each tries to gain a foothold. (marksdailyapple.com)
- Estrogen is made from testosterone. (marksdailyapple.com)
- Without testosterone, women would be unable to produce estrogen. (marksdailyapple.com)
- Testosterone is responsible for the production of estradiol, which is the primary estrogen in non-pregnant women, up until menopause hits. (marksdailyapple.com)
- Taking medicines with estrogen or testosterone (including birth control), digoxin, spironolactone, and barbiturates may interfere with the test. (wikihow.com)
- Resveratrol - boosts testosterone whereas suppressing estrogen ranges in the physique. (dailystrength.org)
- This includes testosterone as well as estrogen. (livestrong.com)
Injections13
- Although 84 percent of the study subjects, with an average age of 67, were men, testosterone treatment with patches, gels or injections also produced improvements in women. (go.com)
- If you have low testosterone , one way to improve sperm count is with gonadotropin injections. (webmd.com)
- If it's below normal, we can then inject the signal to produce more testosterone," Mezitis says of gonadotropin injections. (webmd.com)
- According to an article in the journal F1000 Research , the main ways doctors administer testosterone is through injections or transdermally via a person's skin. (medicalnewstoday.com)
- A person may receive injections of testosterone from their doctor, or the doctor might allow them to inject themselves at home. (medicalnewstoday.com)
- These injections will typically be either testosterone enanthate or testosterone cypionate, which people use every 1 to 2 weeks. (medicalnewstoday.com)
- Using testosterone creams, gels, pills or injections to boost libido in women is complicated and controversial-and until we know more about it, I don't personally recommend it. (womansday.com)
- Sometime after that test - which the researchers used to assess initial heart health - one in seven of the men started using testosterone gels, patches or injections. (reuters.com)
- When I went off testosterone injections for the same reason I went through a withdrawal! (healthboards.com)
- For instance, many men using testosterone injections report that they are feeling more energized and more able to take on arduous tasks. (infobarrel.com)
- Testosterone is available as a gel or patch, muscular injections, or tablets that can be dissolved under the tongue. (wikihow.com)
- A flood of testosterone products has hit the market in recent years, including gels, tablets, patches, injections, and even a buccal patch. (medpagetoday.com)
- 3 Measurements are recommended 3 to 6 months after initiation of treatment, earlier (at 1 week) for men receiving testosterone enanthate or cypionate injections, and midway between injections thereafter to determine appropriate frequency and dosage. (questdiagnostics.com)
Hormones11
- Oysters, tuna and egg yolks are also foods that contain vitamins and minerals that can aid in the increase of testosterone hormones. (slideshare.net)
- These hormones signal the testes to make more testosterone, vital for a healthy sperm count . (webmd.com)
- Testosterone is in a class of medications called androgenic hormones. (medlineplus.gov)
- The natural production of testosterone is controlled by another set of hormones called gonadotrophins, which are released from the pituitary gland in the brain. (netdoctor.co.uk)
- Furthermore, hormones other than testosterone and its derivatives also may be involved in the modulation of aggression. (britannica.com)
- Basically, Macafem has a positive impact on endocrine system - a group of glands that release hormones including testosterone. (buzzle.com)
- In a recent study published in The New England Journal of Medicine, 814 postmenopausal women with low sexual desire were given a patch containing 150 or 300 mcg/day of testosterone, or no hormones at all (control group). (womansday.com)
- Natural News) A recent study showed that men are not prone to releasing male hormones such as testosterone when engaged in a virtual competition compared with when they are playing against actual foes in a face-to-face challenge. (naturalnews.com)
- Its function is right there in the name - it binds to the sex hormones, especially testosterone and estradiol, and inhibits their function. (marksdailyapple.com)
- Like all hormones, testosterone is a chemical messenger secreted by one body tissue that then travels to another tissue to affect growth and behavior. (giantmicrobes.com)
- When a man has prostate cancer, the cancer feeds on male hormones, including testosterone. (healthcentral.com)
Deficiency10
- Dr Antonio and her colleagues set out to determine whether free testosterone or total testosterone is more closely associated with hypogonadal signs and symptoms and whether free testosterone might potentially be a more accurate diagnostic tool for testosterone deficiency, given the backdrop of the 2010 US Endocrine Society guidelines. (medscape.com)
- Testosterone Deficiency Syndrome -- What you need to know. (medhelp.org)
- If you are suffering from a majority of these symptoms, however, testosterone deficiency is certainly something you should consider. (everything2.com)
- How significant would a nutritional deficiency/malabsorption problem have to be in order to cause a persons testosterone to decrease? (medhelp.org)
- Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: A densitometric, morphometric and biomechanical study. (nih.gov)
- A testosterone deficiency should not be ignored as it has been linked to a variety of heart problems. (buzzle.com)
- If you are looking for a reliable natural supplement to spice up your sexual life that has taken a nose dive due to testosterone deficiency then Macafem is a good option. (buzzle.com)
- Another natural supplements helpful for women suffering from testosterone deficiency, is wild yam powder which contains steroidal sapogenins. (buzzle.com)
- Appropriate your Zinc and Vitamin D Deficiency: These two vitamins are needed to your body to be able to produce testosterone. (dailystrength.org)
- Testosterone deficiency can be a contributing factor to decreases in bone mineral density. (livestrong.com)
Libido13
- Testosterone isn't only about sex drive , although a low libido is one of the more noticeable signs of having a low testosterone level. (everything2.com)
- Saw palmetto may boost libido by stopping the breakdown of testosterone in the body. (healthline.com)
- Restoring testosterone balance through Macafen supplements works to raise libido and turbocharge your sex drive. (buzzle.com)
- Testosterone plays a key role in libido (sex drive) in men. (selfgrowth.com)
- Reader Question: I've heard that women can use testosterone to increase their libido. (womansday.com)
- As noted above, low-dose testosterone treatment may help raise libido for some women, but it can also cause facial hair to grow. (americanscientist.org)
- These symptoms of low testosterone all have to do with optimum functioning as a man and include the loss of ability to concentrate, loss of motivation, exhaustion, fatigue, depression, troubling sleeping, oversleeping, lack of libido, and impotence. (infobarrel.com)
- Testosterone, as the regulator of sex function, can make a huge difference in the quality of a person's sex life improving erectile function and libido. (infobarrel.com)
- Female libido is inextricably linked to testosterone. (marksdailyapple.com)
- I'm just pointing out that increasing testosterone in women does increase libido. (marksdailyapple.com)
- While contributing to libido and orgasm, testosterone also helps to maintain their normal metabolic function, muscle strength, cognitive function and mood. (afr.com)
- Testosterone supplements promise men a butch boost of resurrected libido, energy and mood. (newscientist.com)
- Declining testosterone may cause a decline in libido, Erectile Dysfunction (ED), and difficulty achieving ejaculation. (exrx.net)
Total testosterone9
- Most doctors measure total testosterone as the starting point, and for American men under the age of 40, the normal range is 300 to 1,000 nanograms per deciliter of blood. (menshealth.com)
- Standardization of total testosterone (TT) measurements in serum will be established through method comparison and bias estimation between the CDC Reference Laboratory and the testing laboratory. (cdc.gov)
- The materials underwent 2 freeze-thaw cycles and are within the range of total testosterone commonly observed in males and females in most adult populations. (cdc.gov)
- In Phase 1 , 40 samples, with 1.0 mL each, will be sent to the participant, with total testosterone concentrations assigned. (cdc.gov)
- Our results suggest that free testosterone is more informative than total testosterone," she told attendees. (medscape.com)
- These suggest the additional measurement of free-testosterone level in some men in whom total-testosterone concentrations are near the lower limit of the normal range and/or in whom alterations in SHBG are suspected. (medscape.com)
- The most common test is for "total testosterone," which is the testosterone that is bound to other proteins in the blood. (wikihow.com)
- If your total testosterone from your screening lab test comes back abnormal, ask to have the test for "free" or bioavailable testosterone. (wikihow.com)
- approximately 2% of total testosterone is free (not bound to protein). (questdiagnostics.com)
Decreases7
- Because low testosterone decreases bone mass, men who suffer from it may develop osteoporosis , leading to an increased risk of bone fracture s, particularly in the hip and spine. (everything2.com)
- Some men take saw palmetto so their body's level of dihydrotestosterone decreases and the level of testosterone increases. (healthline.com)
- Testosterone production typically decreases with age. (selfgrowth.com)
- Men can experience a range of symptoms if testosterone decreases more than it should. (selfgrowth.com)
- We show that compared with the placebo, testosterone significantly decreases interpersonal trust, and, as further analyses established, this effect is determined by those who give trust easily. (pnas.org)
- Testosterone decreases by approximately 1% per year after age 30 (Brawer 2004, Harris 2011) whereas both free and albumin-bound testosterone declined at about 2% per year. (exrx.net)
- As testosterone decreases, the tummy zone will plump up, says Dr. Goodman. (cosmopolitan.com)
Level of testosterone3
- An adequate level of testosterone in the body is necessary for the overall well-being. (buzzle.com)
- They will need to check the level of testosterone in your blood. (nationwidechildrens.org)
- The level of testosterone appears to influence sexual function. (exrx.net)
Production of testosterone6
- Backed by scientific evidence and approved by doctors, Macafem encourages natural secretion of home by stimulating the glands involved in the production of testosterone. (buzzle.com)
- If a man catches the disease early in his life, it could cause long-term problems for the production of testosterone. (healthcentral.com)
- A diet in which less than 20 percent of the calories come from fat limits your body's production of testosterone. (livestrong.com)
- LH can then stimulate the membrane receptors of the Leydig cells in the testes to stimulate the production of testosterone (Kraemer, 1988). (exrx.net)
- The production of dyhydrotestosterone is 1/20th of the production of testosterone. (exrx.net)
- See production of testosterone in testes . (exrx.net)
Supplements23
- Aside from the mentioned benefits, here are more of the benefits that one can gain from taking testosterone supplements: 1)The fats in the body will be replaced with muscles. (slideshare.net)
- Taking testosterone supplements allow them to perform better and eventually create a better mood. (slideshare.net)
- We don't want patients and their loved ones rushing to buy testosterone supplements online, or physicians to misinterpret the findings," said Ezekowitz, who led the meta-analysis published today in the American Heart Association's journal Circulation Heart Failure. (go.com)
- What testosterone supplements should I take? (medicalnewstoday.com)
- Usually, a person should only take testosterone supplements if they have a medical condition that causes low testosterone. (medicalnewstoday.com)
- There are many testosterone supplements available to buy over the counter that purport to increase a person's testosterone. (medicalnewstoday.com)
- According to the previous article in American Journal of Men's Health , manufacturers market various herbal supplements as improving testosterone and are sometimes available in combination with DHEA. (medicalnewstoday.com)
- Does a person need to take testosterone supplements? (medicalnewstoday.com)
- Which drugs or supplements interact with testosterone undecanoate-oral capsule? (medicinenet.com)
- Can Testosterone Supplements Improve Your Sex Drive? (healthline.com)
- The herb has excellent testosterone enhancing potential and therefore supplements derived from it also help to improve testosterone production. (buzzle.com)
- In the study, about 150 men age 60 and older were given daily testosterone supplements , and another 150 took a placebo. (livescience.com)
- Dr. Elizabeth Kavaler, a urology specialist at Lenox Hill Hospital in New York City who was not involved in the research, said that testosterone supplements may have a benefit for men whose testosterone level is lower than that of the men in the study - between 150 and 300 nanograms per deciliter. (livescience.com)
- Although some men may have the perception that testosterone supplements will make them stronger or more virile, "giving a guy testosterone is not the fountain of youth," Kavaler told Live Science. (livescience.com)
- Rather, the study was aimed at determining whether testosterone supplements affect the progression of atherosclerosis - the thickening and hardening of arterial walls. (livescience.com)
- A separate study designed to focus on sexual function would provide stronger evidence of whether testosterone supplements affect men's sex lives. (livescience.com)
- Results also indicate that testosterone supplements may have "moderate positive effects on selective cognitive domains (e.g. spatial ability)", Dr Beauchet wrote in the European Journal of Endocrinology . (psychcentral.com)
- Between 2000 and 2011, prescriptions for testosterone supplements in the US more than quadrupled (see graph) and in 2011 an estimated 5.3 million prescriptions were issued . (newscientist.com)
- Although nowhere near US figures yet, sales of testosterone supplements in the UK, Australia and Germany are also on the increase. (newscientist.com)
- For the males out there reading about learn how to get trim with the very best promoting eating regimen dietary supplements , it is essential to know that something that goes hand in hand with changing into leaner is your body's ability to supply testosterone. (dailystrength.org)
- Nevertheless, a stellar testosterone isn' natural t booster supplements all you'll get from testosterone boosters. (dailystrength.org)
- Sheer Testosterone Booster brings together a potent blend of 8 scientifically proven T" boosting dietary supplements to supercharge your anabolic environment. (dailystrength.org)
- There are a great number of quality free resources online for men who wish to learn more about how natural supplements for testosterone work as well as receive unbiased testimonials and reviews of various T boosting supplements. (infobarrel.com)
Researchers22
- As men age, their sexual function, vitality and strength can decline, but researchers had not yet established whether testosterone treatment is actually beneficial. (ufl.edu)
- The researchers found that the treatment increased the blood testosterone level from moderately low to mid-normal in men ages 19-40 and improved all aspects of sexual function, including sexual activity, sexual desire and the ability to get an erection. (ufl.edu)
- Researchers screened 51,085 men and found 790 who had a sufficiently low testosterone level to be part of the study. (ufl.edu)
- Researchers at the Perelman School of Medicine at the University of Pennsylvania designed and coordinated the Testosterone Trials, a series of studies at 12 academic medical centers across the United States. (cnn.com)
- The researchers randomly assigned half the participants to use a daily testosterone gel and the other half a placebo gel for one year. (cnn.com)
- A team of international researchers - led by Carlos Martinez of the Institute for Epidemiology, Statistics and Informatics GmbH in Frankfurt, Germany - decided to investigate the risk of VTE associated with testosterone treatment in men, with a focus particularly on the timing of the risk. (medicalnewstoday.com)
- After adjusting for comorbidities and other influencing factors, researchers estimated the rate ratios of VTE in association with current testosterone treatment and compared it with no treatment. (medicalnewstoday.com)
- In the first 6 months of testosterone treatment, researchers found a 63 percent increased risk of VTE. (medicalnewstoday.com)
- Researchers from the University of Bonn gave 46 people testosterone gel and 45 people a placebo. (hindustantimes.com)
- After paying out the participants, the researchers found that men who received the testosterone gel self-reported their numbers more honestly, said researchers. (hindustantimes.com)
- Researchers from Wayne State University also compared two groups of men competing to win the attention of an attractive woman and found that men with lower testosterone didn't even stand a chance. (hindustantimes.com)
- To test this hypothesis, the researchers had 54 female volunteers ingest a liquid solution several hours before participating in an investing game - some volunteers received a placebo solution, while others received a solution with added testosterone. (psychcentral.com)
- Just as the researchers predicted, testosterone seemed to promote antisocial behavior in response to a potential threat - in this case, a threat to financial resources. (psychcentral.com)
- So it's unclear what the findings mean for younger, healthier men who take testosterone, researchers said. (reuters.com)
- When the researchers took into account the extent of men's initial artery blockages, they calculated that using testosterone was tied to a 29-percent higher risk of heart attack, stroke or death. (reuters.com)
- In fact, men who started using testosterone initially had fewer health problems than those who didn't, the researchers wrote Tuesday in the Journal of the American Medical Association. (reuters.com)
- No, it's testosterone, the essence of manhood, that some researchers say is directly responsible for causing financial turmoil, and that it needs to be curtailed. (naturalnews.com)
- Although men in the testosterone group did report a slight improvement in their satisfaction with intercourse, the effect was small and could have been due to chance, the researchers said. (livescience.com)
- German researchers found that when they administered testosterone to a group of 46 men, they cheated less on a dice game than 45 men that were given placebo. (ibtimes.com)
- The researchers saw that in general, subjects that received testosterone reported lower numbers and received lower payoffs than the subjects in the control group. (ibtimes.com)
- Researchers are uncovering more and more about testosterone and how it connects to men's health. (feedburner.com)
- The researchers found the usual decline in testosterone with age. (psychcentral.com)
Enanthate3
- Testosterone Enanthate Norma may be available in the countries listed below. (drugs.com)
- Along with testosterone enanthate, testosterone cypionate, and testosterone propionate, testosterone undecanoate is one of the most widely used testosterone esters. (wikipedia.org)
- These values are substantially longer than those of testosterone enanthate (which, in castor oil, has values of 4.5 days and 8.5 days, respectively). (wikipedia.org)
Lower testosterone1
- We expected that men would have lower testosterone. (medicinenet.com)
Testes7
- So it stops sending signals to the testes to make more testosterone. (webmd.com)
- But when your testes don't make more testosterone, your sperm production goes down. (webmd.com)
- A surge in testosterone (from the testes-hence the name) in adolescence boosts us into manhood. (menshealth.com)
- Testosterone, which plays an important role in sexual development, is produced mainly by the testes in boys and in much smaller amounts by the ovaries in girls. (kidshealth.org)
- HCG, or human chorionic gonadotropin, can be administered either at the end of a testosterone cycle, or during the cycle, to kick start the testes into producing testosterone again, and will usually return the testes to near normal size. (thebody.com)
- If a man is experiencing the symptoms of low testosterone - low sex drive, fatigue, muscle loss, depression- he should consider being checked for an injury to his testes. (healthcentral.com)
- Testosterone is secreted by the testes in men. (questdiagnostics.com)
Ovaries4
- Use of testosterone can help increase sexual desire in menopausal women with hypoactive sexual desire disorder (HSDD), particularly in those patients who have had surgical removal of their ovaries. (medscape.com)
- To answer her first question, testosterone is indeed present in women, produced primarily in their ovaries and adrenal glands. (americanscientist.org)
- Young women produce most of their testosterone in the ovaries. (marksdailyapple.com)
- Women need testosterone too and the ovaries and adrenal glands produce it in low amounts. (giantmicrobes.com)
Naturally4
- Female Sprinter with Naturally High Testosterone. (runnersworld.com)
- I'm curious to know whether females also have a type of enzyme that would convert estradiol into testosterone, or is it naturally produced in their tissues? (americanscientist.org)
- Not all cases of low testosterone are a product of the body naturally malfunctioning. (healthcentral.com)
- The lucky men, who discover how to replace testosterone naturally, report that these symptoms subside and they are able to continue with a highly productive life, many saying that they feel thirty years younger. (infobarrel.com)
Symptoms of low6
- The symptoms of low testosterone are not always useful in diagnosis , however. (everything2.com)
- However, St Louis University has put together the following self-screening questionnaire of ten basic questions to help men identify symptoms of low testosterone. (everything2.com)
- However, with new testosterone replacement therapies, many men are beating back these symptoms of low testosterone, with some reporting that they feel and function as well as they did when they were thirty years younger. (infobarrel.com)
- Look for symptoms of low testosterone in men. (wikihow.com)
- Monitor your body to see if you have any symptoms of low testosterone. (wikihow.com)
- Check for symptoms of low testosterone in women. (wikihow.com)
Increases4
- Testosterone increases a man's sex drive and helps him compete for a mate. (bbc.co.uk)
- We suggest that testosterone adaptively increases social vigilance in these trusting individuals to better prepare them for competition over status and valued resources. (pnas.org)
- Analysis has confirmed repeatedly that top-depth physique constructing (selecting weights so that you attain muscle failure by 10 reps) can stimulate increases in testosterone secretion. (dailystrength.org)
- When a person increases testosterone production the symptoms, by and large, will go away. (infobarrel.com)
Decrease6
- Most men after the age of 70 have low testosterone, decrease in muscle strength and decreased bone mass . (everything2.com)
- Testosterone can decrease in blood glucose , therefore insulin requirements may change in diabetic patients. (medicinenet.com)
- Because testosterone plays a role in building muscle, men with low T might notice a decrease in muscle mass. (selfgrowth.com)
- Testosterone is also involved with the production of red blood cells and sperm and can decrease as a man ages. (wikihow.com)
- however, a steep decrease in testosterone could be the product of a more serious condition. (healthcentral.com)
- If you lose lean muscle mass due to a decrease in testosterone production, your metabolism will slow down, which limits your ability to burn stored fat for energy. (livestrong.com)
Higher testosterone2
- Dr. Catherine Cohan, assistant professor of human development and family studies, says, "It's not necessarily the case that higher testosterone is all bad. (scienceblog.com)
- Men who have low testosterone talk more about their energy, feeling mental and physically better when they have a higher testosterone," says Goodman. (cosmopolitan.com)
Undecanoate28
- What is testosterone undecanoate-oral capsule, and how does it work (mechanism of action)? (medicinenet.com)
- The FDA approved testosterone undecanoate in March 2014. (medicinenet.com)
- What brand names are available for testosterone undecanoate-oral capsule? (medicinenet.com)
- Is testosterone undecanoate-oral capsule available as a generic drug? (medicinenet.com)
- Do I need a prescription for testosterone undecanoate-oral capsule? (medicinenet.com)
- What is the dosage for testosterone undecanoate-oral capsule? (medicinenet.com)
- Safe and effective use of testosterone undecanoate is not determined for males under 18 years of age. (medicinenet.com)
- Is testosterone undecanoate-oral capsule safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
- Testosterone undecanoate is not recommended for pregnant women or in women who may become pregnant. (medicinenet.com)
- Although it is not known whether testosterone undecanoate enters breast milk, it is not recommended for nursing mothers due to high risks of infant harm and serious adverse events. (medicinenet.com)
- What else should I know about testosterone undecanoate-oral capsule? (medicinenet.com)
- What preparations of testosterone undecanoate-oral capsule are available? (medicinenet.com)
- How should I keep testosterone undecanoate-oral capsule stored? (medicinenet.com)
- Testosterone undecanoate is stored between 15 C to 30 C (59 F to 86 F), in original cartons until use. (medicinenet.com)
- All of these have now largely been replaced by either a transdermal gel - Testogel, Testim, Androderm etc or a long-acting deep intramuscular injection called Nebido and containing 1,000 mg of Testosterone Undecanoate in 4ml oily suspension. (selfgrowth.com)
- Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body. (wikipedia.org)
- Testosterone undecanoate was introduced in China for use by injection and in Europe for use by mouth in the 1970s. (wikipedia.org)
- In addition to its medical use, testosterone undecanoate is used to improve physique and performance. (wikipedia.org)
- Conversely, oral testosterone undecanoate must be taken two or three times a day with food. (wikipedia.org)
- The Reandron 1000 formulation (Nebido in the United States) contains 1,000 mg of testosterone undecanoate suspended in castor oil with benzyl benzoate for solubilization and as a preservative, and is administered by intramuscular injection. (wikipedia.org)
- Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. (wikipedia.org)
- Testosterone undecanoate is administered via intramuscular injection once every three months or so. (wikipedia.org)
- Testosterone undecanoate, or testosterone 17β-undecanoate, is a synthetic androstane steroid and a derivative of testosterone. (wikipedia.org)
- specifically, it is the C17β undecylate (undecanoate) ester of testosterone. (wikipedia.org)
- In the late 1970s, testosterone undecanoate was introduced for oral use in Europe, although intramuscular testosterone undecanoate had already been in use in China for several years. (wikipedia.org)
- Intramuscular testosterone undecanoate was not introduced in Europe and the United States until much later, in the early to mid 2000s and 2014, respectively. (wikipedia.org)
- Testosterone undecanoate was approved in the United States after three previous rejections due to safety concerns. (wikipedia.org)
- Testosterone undecanoate is the generic name of the drug and its USAN and BAN. (wikipedia.org)
Take testosterone5
- Take testosterone at around the same times every day. (medlineplus.gov)
- Take testosterone exactly as directed. (medlineplus.gov)
- Your doctor will probably tell you that you should not take testosterone. (medlineplus.gov)
- NEW YORK (Reuters Health) - Older men who take testosterone are more likely to have a heart attack or stroke or die over the next few years, new research indicates. (reuters.com)
- Final however not least, it's all the time extremely beneficial that you've a quick speak with your family physician or general practitioner before beginning to take testosterone boosters. (dailystrength.org)
Produce testosterone4
- My body doesn't produce Testosterone anymore because of Hemochromatosis, which is a blood disease which produces too much iron in my blood. (healthboards.com)
- In addition, celery is an excellent source of vitamin K, which might actually boost a man's ability to produce testosterone. (livestrong.com)
- This is because body fat converts testoterone to estradiol, which potentially reduces your body's ability to produce testosterone. (livestrong.com)
- Your ability to produce testosterone depends heavily upon your dietary fat intake. (livestrong.com)
AndroGel8
- A new testosterone gel, AndroGel 1% was released in August 2000 is now available pharmaceutical. (earthlink.net)
- If you have lost a family member to a heart attack or other cardiac incident and believe testosterone therapies such as Androgel or Testim may have been the cause, contact testosterone lawyers handling national claims to learn about your legal rights. (prweb.com)
- That drove sales of topical testosterone drugs like AndroGel and Axiron $2 billion a year, with AbbVie taking more than 65% of the market, according to market researcher IMS Health. (forbes.com)
- The new gel approved this past summer, Androgel by Unimed Pharmaceuticals Inc., is the easiest way to supplement testosterone as it is a clear gel that is rubbed into the skin once a day. (thebody.com)
- Some patients have already filed a testosterone lawsuit in federal court alleging AndroGel caused heart attack or stroke without warning. (prweb.com)
- If the serum testosterone concentration is below the normal range, the daily AndroGel dose may be increased from 5 g to 7.5 g and from 7.5 g to 10 g for adult males as instructed by the physician. (nih.gov)
- If the serum testosterone concentration exceeds the normal range, the daily AndroGel dose may be decreased. (nih.gov)
- 3 1/2 years of depression after surgery prior to Hypogonadizm DX, Testosterone Theropy (Testim Gel)since 12/06 but switched to a higher dose of (Androgel) 6/08. (healingwell.com)
Free and albumin-bound testosterone1
- Both free and albumin-bound testosterone are biologically active, and together are referred to as the bioavailable fraction. (questdiagnostics.com)
Boosters6
- 1. Increasing Testosterones with Testosterone Boosters Aging can take a toll on a persons body. (slideshare.net)
- Testogen is at the moment one of the high-rated testosterone boosters available in the market as a consequence of its effectiveness rising power in the physique. (dailystrength.org)
- When you fall in that class, cease wasting your cash shopping for testosterone boosters. (dailystrength.org)
- This is one of the safest and finest Pure Testosterone Boosters available on the market as of 2017, for casual gymnasium-goers and people over 30. (dailystrength.org)
- With boosters, you are trying to trick your physique into making extra testosterone by itself. (dailystrength.org)
- All you need to do is to get on a regimen of nonprescription testosterone boosters and take them for two months. (infobarrel.com)
Replacement11
- T pellets ( Testopel ) are used for long term T replacement in men and can be inserted beneath the skin of the stomach to deliver testosterone (T) over a 3 month period. (earthlink.net)
- Your doctor may need to perform a digital rectal exam to check your prostate gland at least once a year while you are receiving testosterone replacement (more frequently than this if you are elderly or have risk factors for prostate cancer). (netdoctor.co.uk)
- Each plaintiff's case addresses only one of these defendants, yet the claims against them - specifically that testosterone replacement therapies have allegedly caused patients to have heart attacks and strokes - are common across every one of these testosterone lawsuits, according to the official court documents," explains Jim Onder of the Onder Law Firm. (prweb.com)
- Plaintiffs in a multidistrict litigation over testosterone replacement drugs on Monday agreed to dismiss remaining cases against Pfizer Inc, following a federal appeals court ruling in January that claims against the company were preempted. (reuters.com)
- The decision allows Pfizer to fully escape the litigation in which plaintiffs claim several companies failed to warn of the risks of strokes and heart attacks connected to the use of their testosterone replacement products. (reuters.com)
- Research is inconclusive regarding the role of testosterone replacement in the treatment of erectile dysfunction. (selfgrowth.com)
- I'd like to point out many of the benefits of testosterone replacement in this article so that people suffering from loss of testosterone can decide if they want to proceed with a testosterone treatment. (infobarrel.com)
- Many men describe the difference in their quality of life before and after beginning a testosterone replacement program as night and day. (infobarrel.com)
- What are the delivery systems now for testosterone replacement? (selfgrowth.com)
- There are several means of testosterone replacement theropy such as gels or shots but most doctors don't like prescribing it for anyone with a history of prostate cancer. (healingwell.com)
- In response to this, many psychiatrists, who are unfamiliar with testosterone replacement research, will actually INCREASE the patient's antidepressants causing the symptoms to become even more pronounced. (infobarrel.com)
Placebo7
- The subjects were randomized into two groups: one that applied a daily testosterone gel and the other a daily placebo gel, for one year. (ufl.edu)
- Across the three trials, adverse events including heart attack, stroke, other cardiovascular events and prostate conditions were similar in men who received testosterone and those who received a placebo. (ufl.edu)
- Yet the number of cardiovascular events, such as heart attacks, was similar for the men treated with testosterone and those using placebo. (cnn.com)
- Participants who received the placebo, on the other hand, were more trusting investors, choosing to invest about €3.20 more than those who received testosterone. (psychcentral.com)
- In this case, participants given testosterone chose to give more money back to the investor than participants who had been given a placebo. (psychcentral.com)
- The following experiment tests this possibility in a placebo-controlled, within-subjects design involving the administration of testosterone to 24 female subjects. (pnas.org)
- A phase II trial lasting 84 days reported more orgasms with nasal testosterone than with placebo: 2.3 versus 1.7. (medpagetoday.com)
Gels2
- And although testosterone shots, pellets and gels are effective, they are not tolerable or appropriate for many patients, such as men trying to conceive, and are certainly less convenient than making your own testosterone. (news-medical.net)
- Professor Davis, who is president of the International Menopause Society , says because of possible adverse effects from oral testosterone, non-oral formulations, delivered through gels or patches into the skin, are preferred for women. (afr.com)
Males5
- Q. Will the use of testosterone cause a female to exhibit signs that are typical of males? (earthlink.net)
- The close link between aggression and testosterone is not surprising, given that males of many species fight over access to fertile females, but the connection is complex. (britannica.com)
- To date, psychologist James McBride Dabbs ' Heroes, Rogues, and Lovers (2000) is the best book to investigate not simply the physical effects of high testosterone in males, but its mental and emotional ramifications as well. (psychologytoday.com)
- Dose adjustment for adult males: If serum testosterone level is below the normal range, adjust dose from 5 g to 7.5 g and from 7.5 g to 10 g ( 2.3 ). (nih.gov)
- Resting testosterone values for mature males range from 14.0 to 28.0 nmol/L (Kraemer, 1988). (exrx.net)
Sperm14
- In fact," Eisenberg says, "it's been studied as a method of birth control , because 90% of men can drop their sperm counts to zero while on testosterone . (webmd.com)
- Testosterone plays an important role in making sperm. (webmd.com)
- Eisenberg describes the relationship between testosterone and sperm production as part of a "feedback loop. (webmd.com)
- You want to increase the patient's own testosterone production in order to get an appropriate sperm sample for pregnancy ," says Mezitis, who practices at Lenox Hill Hospital in New York City. (webmd.com)
- When testosterone comes from the outside, it suppresses the body's production of sperm. (webmd.com)
- If his sperm count is low, the next step is to measure his testosterone. (webmd.com)
- During adult life, testosterone is essential for the production of sperm, the maintenance of sex drive, erectile potency, and the functioning of the prostate gland and other reproductive structures. (netdoctor.co.uk)
- Testosterone also contributes to muscle strength , bone strength and density , sense of well being , red blood cell mass , adequate sperm count, sexual performance and penis growth during puberty . (everything2.com)
- Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone , sperm and prostate parameters. (nih.gov)
- In men, sperm production is guided by testosterone. (healthline.com)
- Too little testosterone results in low sperm count. (healthline.com)
- Testosterone plays a role in the production of semen , which is the milky fluid that aids in the motility of sperm. (selfgrowth.com)
- You need testosterone to make sperm, and if you have a very low testosterone, you might have a decline in the quality of sperm and number of sperm, says Streicher. (cosmopolitan.com)
- But, believe it or not, men with extremely low testosterone can still produce normal sperm. (cosmopolitan.com)
Man's sex drive1
- While testosterone stimulates a man's sex drive, it also aids in achieving and maintaining an erection. (selfgrowth.com)
Benefits of taking testo1
- However, the possible benefits of taking testosterone need to be in a balance with the higher risks of cardiovascular events. (medicalnewstoday.com)
Pituitary2
- The brain's hypothalamus and pituitary gland control testosterone production. (giantmicrobes.com)
- Because low testosterone may be an indicator for an underlying problem, like a problem with the pituitary gland, liver disease, an inherited disease, or Addison's disease, your doctor may want to test you for an underlying problem if you have low testosterone. (wikihow.com)
Testicles2
- These include baldness, prostate enlargement, shrinking of testicles, increased acne and loss of sex drive with moodiness and emotionality.Testosterone USP is a white odorless powder which dissolves in alcohol or organic solvents. (earthlink.net)
- In men, testosterone is produced by the testicles with a small amount made in the adrenal glands. (giantmicrobes.com)
Lowers1
- What magnesium does is it lowers the SHBG rely by quite a bit, granting the free testosterone within the physique to increase by a big number. (dailystrength.org)
SHBG2
- If you have a low level of SHBG, you may have a high level of free testosterone in your bloodstream. (healthline.com)
- SHBG-bound testosterone is so tightly bound that it is not biologically active. (questdiagnostics.com)
Dose4
- The patient could consider trying a lower dose (and/or application frequency) of topical testosterone. (medscape.com)
- If your testosterone buccal system does not stick or falls off within 8 hours after you apply it, replace it with a new system immediately and apply your next dose at the regularly scheduled time. (medlineplus.gov)
- Doctors should also ensure the patients are being prescribed the lowest dose of opioids, including methadone, for effective treatment to minimize testosterone suppression," she says in a news release. (medicinenet.com)
- The article that I think I remember (inserting aging joke of choice here) used relatively high-dose testosterone given intramuscularly once a week. (exrx.net)
Dihydrotestosterone3
- Dihydrotestosterone (DHT) is made from testosterone by an enzyme. (healthline.com)
- Saw palmetto works by stopping the breakdown of testosterone into its byproduct, dihydrotestosterone. (healthline.com)
- This byproduct helps the body hold on to more of its testosterone and create less dihydrotestosterone, which can slow or stop the growth of the prostate gland. (healthline.com)
Suggests5
- Although less information is available regarding non-sexuality quality-of-life enhancements with use of testosterone, anecdotal experience suggests some women will experience the improved energy, as noted by this 60-year-old surgically castrate woman. (medscape.com)
- The 2007 study suggests that although poor health in general is associated with a drop in testosterone , this generational decline cannot be fully explained by obesity, depression, or diabetes. (huffingtonpost.com)
- New research suggests testosterone can promote generosity, but only when there is no threat of competition. (psychcentral.com)
- One study suggests that testosterone affects activity in the orbitofrontal cortex, a part of the brain thought to be involved in deception. (ibtimes.com)
- Although vitamin K primarily helps your blood to clot, a study published in "Food and Function" in 2011 suggests that the amount of vitamin K in a man's body might affect testosterone production. (livestrong.com)
Aggression4
- Testosterone is related to assertiveness which can be good or bad depending on whether it is manifested as either aggression or being helping and outgoing. (scienceblog.com)
- Castration has been found to reduce aggression dramatically, while experimental reinstatement of testosterone-for instance, through injection into the blood-restores aggression. (britannica.com)
- In addition, testosterone of nongonadal origin (i.e., produced by the adrenal gland ) may be important in aggression outside the breeding season, as in the case of birds such as the song sparrow that maintain nonbreeding territories in the winter. (britannica.com)
- Unlike non-human animals, where a direct connection between testosterone and aggression has been repeatedly demonstrated, in humans the correlation between high-T and aggression, though positive, is only weakly so. (psychologytoday.com)
Adrenal1
- Testosterone is also produced by the adrenal glands in both girls and boys. (kidshealth.org)
Lack of testosterone1
- It s true that a lack of testosterone translates to a lack of body hair, but generally speaking, a guy isn t bald because he s low on testosterone, nor is he a hairy beast because he he s full of it. (cosmopolitan.com)
Role of testosterone2
- The literature supports a modulating role of testosterone on erectile function. (cmaj.ca)
- As interesting as this subject was, the article left me curious about the role of testosterone in females. (americanscientist.org)
Prescriptions for testosterone4
- The issue is less of problem in Europe, but prescriptions for testosterone have also increased there, by 30% in the United Kingdom, for example. (medscape.com)
- Prescriptions for testosterone nearly doubled in the three years ending in 2013, to 2.3 million, according to the FDA. (forbes.com)
- Doctors around the world have written a surprising number of prescriptions for testosterone treatment in recent years. (scientificamerican.com)
- If confirmed, the 2011 ratio could mean that perhaps two million older men in the U.S. have been given prescriptions for testosterone. (scientificamerican.com)
Ester1
- A related testosterone ester with a similarly very long duration is testosterone buciclate. (wikipedia.org)
Hormonal3
- There's just that niggling, pervasive stigma of testosterone as the sole hormonal realm of big burly men with bulging muscles, and I guess it's hard to shake, even for my enlightened readership. (marksdailyapple.com)
- You can want it all you want, but without the right hormonal balance, which includes plenty of testosterone for men and women, you're not going to want it. (marksdailyapple.com)
- In conclusion, our data provide unique insights into the hormonal regulation of human sociality by showing that testosterone downregulates interpersonal trust in an adaptive manner. (pnas.org)