A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
The surgical removal of one or both testicles.
A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.
Surgical removal or artificial destruction of gonads.
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.
Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.
Achievement of full sexual capacity in animals and in humans.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
The measurement of an organ in volume, mass, or heaviness.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Sexual activities of animals.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
The psychic drive or energy associated with sexual instinct in the broad sense (pleasure and love-object seeking). It may also connote the psychic energy associated with instincts in general that motivate behavior.
A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.
The family of steroids from which the androgens are derived.
Development of male secondary SEX CHARACTERISTICS in the FEMALE. It is due to the effects of androgenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.
The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).
An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
A count of SPERM in the ejaculum, expressed as number per milliliter.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.
A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
Steroids that contain a ketone group at position 17.
Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.
A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.
Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.
An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.
17 beta-Hydroxy-4-androsten-3-ones. Testosterone derivatives formed by the substitution of one or more hydroxyl groups in any position.
A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.
Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.
The convoluted tubules in the TESTIS where sperm are produced (SPERMATOGENESIS) and conveyed to the RETE TESTIS. Spermatogenic tubules are composed of developing germ cells and the supporting SERTOLI CELLS.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.
An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
The total process by which organisms produce offspring. (Stedman, 25th ed)
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.
A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.
A disorder of sexual development transmitted as an X-linked recessive trait. These patients have a karyotype of 46,XY with end-organ resistance to androgen due to mutations in the androgen receptor (RECEPTORS, ANDROGEN) gene. Severity of the defect in receptor quantity or quality correlates with their phenotypes. In these genetic males, the phenotypic spectrum ranges from those with normal female external genitalia, through those with genital ambiguity as in Reifenstein Syndrome, to that of a normal male with INFERTILITY.
Severe gender dysphoria, coupled with a persistent desire for the physical characteristics and social roles that connote the opposite biological sex. (APA, DSM-IV, 1994)
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
A cutaneous pouch of skin containing the testicles and spermatic cords.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
An endocrine state in men, characterized by a significant decline in the production of TESTOSTERONE; DEHYDROEPIANDROSTERONE; and other hormones such as HUMAN GROWTH HORMONE. Andropause symptoms are related to the lack of androgens including DEPRESSION, sexual dysfunction, and OSTEOPOROSIS. Andropause may also result from hormonal ablation therapy for malignant diseases.
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
Sexual union of a male and a female in non-human species.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Tumors or cancer of the PROSTATE.
A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).
A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Elements of limited time intervals, contributing to particular results or situations.
The surgical removal of one or both ovaries.
Behavior in defense of an area against another individual or individuals primarily of the same species.
Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)
Social structure of a group as it relates to the relative social rank of dominance status of its members. (APA, Thesaurus of Psychological Index Terms, 8th ed.)
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.
The processes of anatomical and physiological changes related to sexual or reproductive functions during the life span of a human or an animal, from FERTILIZATION to DEATH. These include SEX DETERMINATION PROCESSES; SEX DIFFERENTIATION; SEXUAL MATURATION; and changes during AGING.
The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
The horn of an animal of the deer family, typically present only in the male. It differs from the HORNS of other animals in being a solid, generally branched bony outgrowth that is shed and renewed annually. The word antler comes from the Latin anteocularis, ante (before) + oculus (eye). (From Webster, 3d ed)
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Hormones produced by the GONADS, including both steroid and peptide hormones. The major steroid hormones include ESTRADIOL and PROGESTERONE from the OVARY, and TESTOSTERONE from the TESTIS. The major peptide hormones include ACTIVINS and INHIBINS.
An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
The capacity to conceive or to induce conception. It may refer to either the male or female.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.

Changed levels of endogenous sex steroids in women on oral contraceptives. (1/7518)

Serum and urinary levels of unconjugated testosterone, dihydrotestosterone, and oestradiol were measured by specific radioimmunoassays in 10 healthy women in the early follicular phase of their menstrual cycle and in nine healthy women taking oral contraceptives. The contraceptive group had testosterone levels 1-3 times higher and dihydrotestosterone levels two times higher than those in the controls. Serum oestradiol levels in the contraceptive group were much lower than those in the controls and similar to levels in postmenopausal women. The contraceptive group had about twice the urinary excretion of unconjugated (free) testosterone and dihydrotestosterone of the controls, but their excretion of unconjugated oestradiol was 2-7 times lower. The great increase in serum and urinary androgen concentrations, as well as the suppression of oestradiol, may be related to the antiovulatory effect of oral contraceptives.  (+info)

The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. (2/7518)

We have examined five human breast cancer cell lines in continuous tissue culture for androgen responsiveness. One of these cell lines shows a 2- to 4-fold stimulation of thymidine incorporation into DNA, apparent as early as 10 hr following androgen addition to cells incubated in serum-free medium. This stimulation is accompanied by an acceleration in cell replication. Antiandrogens [cyproterone acetate (6-chloro-17alpha-acetate-1,2alpha-methylene-4,6-pregnadiene-3,20-dione) and R2956 (17beta-hydroxy-2,2,17alpha-trimethoxyestra-4,9,11-triene-1-one)] inhibit both protein and DNA synthesis below control levels and block androgen-mediated stimulation. Prolonged incubation (greater than 72 hr) in antiandrogen is lethal. The MCF- cell line contains high-affinity receptors for androgenic steroids demonstrable by sucrose density gradients and competitive protein binding analysis. By cross-competition studies, androgen receptors are distinguishable from estrogen receptors also found in this cell line. Concentrations of steroid that saturate androgen receptor sites in vitro are about 1000 times lower than concentrations that maximally stimulate the cells. Changes in quantity and affinity of androgen binding to intact cells at 37 degrees as compared with usual binding techniques using cytosol preparation at 0 degrees do not explain this difference between dissociation of binding and effect. However, this difference can be explained by conversion of [3H]-5alpha-dihydrotestosterone to 5alpha-androstanediol and more polar metabolites at 37 degrees. An examination of incubation media, cytoplasmic extracts and crude nuclear pellets reveals probable conversion of [3H]testosterone to [3H]-5alpha-dihydrotestosterone. Our data provide compelling evidence that some human breast cancer, at least in vitro, may be androgen dependent.  (+info)

Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat. (3/7518)

Hepatic microsome-catalyzed metabolism of aflatoxin B1 (AFB1) to aflatoxin M1 and aflatoxin Q1 and the "metabolic activation" of AFB1 to DNA-alylating metabolite(s) were studied in normal male and female Sprague-Dawley rats, in gonadectomized animals, and in castrated males and normal females treated with testosterone. Microsomes from male animals formed 2 to 5 times more aflatoxin M1, aflatoxin Q1, and DNA-alkylating metabolite(s) than those from females. Castration reduced the metabolism of AFB1 by the microsomes from males by about 50%, whereas ovariectomy had no significant effect on AFB1 metabolism by the microsomes from females. Testosterone treatment (4 mg/rat, 3 times/week for about 6 weeks) of castrated immature males and immature females enhanced the metabolism of AFB1 by their microsomes. A sex difference in the metabolism of AFB1 by liver microsomes was also seen in other strains of rats tested: Wistar, Long-Evans, and Fischer. The activity of kidney microsomes for metabolic activation was 1 to 4% that of the liver activity and was generally lower in microsomes from male rats as compared to those from female rats of Sprague-Dawley, Wistar, and Long-Evans strains. The in vitro results obtained with hepatic microsomes correlated well with the in vivo metabolism of AFB1, in that more AFB1 became bound in vivo to hepatic DNA isolated from male rats and from a female rat treated with testosterone than that isolated from control female rats. These data suggest that the differences in hepatic AFB1 metabolism may be the underlying cause of the sex difference in toxicity and carcinogenicity of AFB1 observed in rats.  (+info)

Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroids. (4/7518)

Freezing injury to the cortical plate of rats induces cerebrocortical microgyria and, in males but not females, a shift toward greater numbers of small neurons in the medial geniculate nucleus (MGN). The purpose of the current study was to examine a hormonal basis for this sex difference. Cross-sectional neuronal areas of the MGN were measured in male rats, untreated female rats and female rats treated perinatally with testosterone propionate, all of which had received either neonatal cortical freezing or sham injury. Both male and androgenized female rats with microgyria had significantly smaller MGN neurons when compared to their sham-operated counterparts, whereas untreated females with microgyria did not. These differences were also reflected in MGN neuronal size distribution: both male and androgenized female rats with microgyria had more small and fewer large neurons in their MGN in comparison to shams, while there was no difference in MGN neuronal size distribution between lesioned and sham females. These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex.  (+info)

Prolactin replacement fails to inhibit reactivation of gonadotropin secretion in rams treated with melatonin under long days. (5/7518)

This study tested the hypothesis that prolactin (PRL) inhibits gonadotropin secretion in rams maintained under long days and that treatment with melatonin (s.c. continuous-release implant; MEL-IMP) reactivates the reproductive axis by suppressing PRL secretion. Adult Soay rams were maintained under long days (16L:8D) and received 1) no further treatment (control, C); 2) MEL-IMP for 16 wk and injections of saline/vehicle for the first 8 wk (M); 3) MEL-IMP for 16 wk and exogenous PRL (s.c. 5 mg ovine PRL 3x daily) for the first 8 wk (M+P). The treatment with melatonin induced a rapid increase in the blood concentrations of FSH and testosterone, rapid growth of the testes, an increase in the frequency of LH pulses, and a decrease in the LH response to N-methyl-D,L-aspartic acid. The concomitant treatment with exogenous PRL had no effect on these reproductive responses but caused a significant delay in the timing of the sexual skin color and growth of the winter pelage. These results do not support the hypothesis and suggest that PRL at physiological long-day concentrations, while being totally ineffective as an inhibitor of gonadotropin secretion, acts in the peripheral tissues and skin to maintain summer characteristics.  (+info)

Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (6/7518)

The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes.  (+info)

Sex steroid and prolactin profiles in male American black bears (Ursus americanus) during denning. (7/7518)

Serum sex steroid and prolactin profiles were examined in the male American black bear, Ursus americanus during denning. Sera collected in December and the following March from 8 denning male black bears in Minnesota, U.S.A. were assayed for testosterone, estradiol-17 beta and prolactin. Eight bears were confirmed to be the denning mode based on a serum urea to creatinine ratio less than 10. Serum testosterone concentrations tended to increase from December to the subsequent March whereas serum estradiol-17 beta concentrations tended to decrease during this period. There were few changes in serum prolactin concentrations between December and March. These findings suggest that spermatogenesis and testicular steroidogenesis initiated during denning may be influenced by changes in serum sex steroid concentrations in the American black bear.  (+info)

BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain. (8/7518)

New neurons are incorporated into the high vocal center (HVC), a nucleus of the adult canary (Serinus canaria) brain that plays a critical role in the acquisition and production of learned song. Recruitment of new neurons in the HVC is seasonally regulated and depends upon testosterone levels. We show here that brain-derived neurotrophic factor (BDNF) is present in the HVC of adult males but is not detectable in that of females, though the HVC of both sexes has BDNF receptors (TrkB). Testosterone treatment increases the levels of BDNF protein in the female HVC, and BDNF infused into the HVC of adult females triples the number of new neurons. Infusion of a neutralizing antibody to BDNF blocks the testosterone-induced increase in new neurons. Our results demonstrate that BDNF is involved in the regulation of neuronal replacement in the adult canary brain and suggest that the effects of testosterone are mediated through BDNF.  (+info)

Testosterone is a steroid hormone that belongs to androsten class of hormones. It is primarily secreted by the Leydig cells in the testes of males and, to a lesser extent, by the ovaries and adrenal glands in females. Testosterone is the main male sex hormone and anabolic steroid. It plays a key role in the development of masculine characteristics, such as body hair and muscle mass, and contributes to bone density, fat distribution, red cell production, and sex drive. In females, testosterone contributes to sexual desire and bone health. Testosterone is synthesized from cholesterol and its production is regulated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Testosterone Propionate is a synthetic form of testosterone, an androgenic hormone naturally produced in the human body. The propionate ester is attached to the testosterone molecule to regulate its release into the bloodstream after injection. This results in a slower release and longer duration of action compared to unesterified testosterone.

Testosterone Propionate is primarily used in medical treatments for conditions associated with low testosterone levels, such as hypogonadism or delayed puberty in males. It helps to stimulate the development of male sexual characteristics, maintain bone density, and support red blood cell production.

It's important to note that Testosterone Propionate is available only through a prescription and its use should be under the supervision of a healthcare professional due to potential side effects and interactions with other medications or health conditions.

Hypogonadism is a medical condition characterized by the inability of the gonads (testes in males and ovaries in females) to produce sufficient amounts of sex hormones, such as testosterone and estrogen. This can lead to various symptoms including decreased libido, erectile dysfunction in men, irregular menstrual periods in women, and reduced fertility in both sexes. Hypogonadism may be caused by genetic factors, aging, injury to the gonads, or certain medical conditions such as pituitary disorders. It can be treated with hormone replacement therapy.

Androgens are a class of hormones that are primarily responsible for the development and maintenance of male sexual characteristics and reproductive function. Testosterone is the most well-known androgen, but other androgens include dehydroepiandrosterone (DHEA), androstenedione, and dihydrotestosterone (DHT).

Androgens are produced primarily by the testes in men and the ovaries in women, although small amounts are also produced by the adrenal glands in both sexes. They play a critical role in the development of male secondary sexual characteristics during puberty, such as the growth of facial hair, deepening of the voice, and increased muscle mass.

In addition to their role in sexual development and function, androgens also have important effects on bone density, mood, and cognitive function. Abnormal levels of androgens can contribute to a variety of medical conditions, including infertility, erectile dysfunction, acne, hirsutism (excessive hair growth), and prostate cancer.

Orchiectomy is a surgical procedure where one or both of the testicles are removed. It is also known as castration. This procedure can be performed for various reasons, including the treatment of testicular cancer, prostate cancer, or other conditions that may affect the testicles. It can also be done to reduce levels of male hormones in the body, such as in the case of transgender women undergoing gender affirming surgery. The specific medical definition may vary slightly depending on the context and the extent of the procedure.

Dihydrotestosterone (DHT) is a sex hormone and androgen that plays a critical role in the development and maintenance of male characteristics, such as facial hair, deep voice, and muscle mass. It is synthesized from testosterone through the action of the enzyme 5-alpha reductase. DHT is essential for the normal development of the male genitalia during fetal development and for the maturation of the sexual organs at puberty.

In addition to its role in sexual development, DHT also contributes to the growth of hair follicles, the health of the prostate gland, and the maintenance of bone density. However, an excess of DHT has been linked to certain medical conditions, such as benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern baldness).

DHT exerts its effects by binding to androgen receptors in various tissues throughout the body. Once bound, DHT triggers a series of cellular responses that regulate gene expression and influence the growth and differentiation of cells. In some cases, these responses can lead to unwanted side effects, such as hair loss or prostate enlargement.

Medications that block the action of 5-alpha reductase, such as finasteride and dutasteride, are sometimes used to treat conditions associated with excess DHT production. These drugs work by reducing the amount of DHT available to bind to androgen receptors, thereby alleviating symptoms and slowing disease progression.

In summary, dihydrotestosterone is a potent sex hormone that plays a critical role in male sexual development and function. While it is essential for normal growth and development, an excess of DHT has been linked to certain medical conditions, such as BPH and androgenetic alopecia. Medications that block the action of 5-alpha reductase are sometimes used to treat these conditions by reducing the amount of DHT available to bind to androgen receptors.

The testis, also known as the testicle, is a male reproductive organ that is part of the endocrine system. It is located in the scrotum, outside of the abdominal cavity. The main function of the testis is to produce sperm and testosterone, the primary male sex hormone.

The testis is composed of many tiny tubules called seminiferous tubules, where sperm are produced. These tubules are surrounded by a network of blood vessels, nerves, and supportive tissues. The sperm then travel through a series of ducts to the epididymis, where they mature and become capable of fertilization.

Testosterone is produced in the Leydig cells, which are located in the interstitial tissue between the seminiferous tubules. Testosterone plays a crucial role in the development and maintenance of male secondary sexual characteristics, such as facial hair, deep voice, and muscle mass. It also supports sperm production and sexual function.

Abnormalities in testicular function can lead to infertility, hormonal imbalances, and other health problems. Regular self-examinations and medical check-ups are recommended for early detection and treatment of any potential issues.

Sex Hormone-Binding Globulin (SHBG) is a protein produced mainly in the liver that plays a crucial role in regulating the active forms of the sex hormones, testosterone and estradiol, in the body. SHBG binds to these hormones in the bloodstream, creating a reservoir of bound hormones. Only the unbound (or "free") fraction of testosterone and estradiol is considered biologically active and can easily enter cells to exert its effects.

By binding to sex hormones, SHBG helps control their availability and transport in the body. Factors such as age, sex, infection with certain viruses (like hepatitis or HIV), liver disease, obesity, and various medications can influence SHBG levels and, consequently, impact the amount of free testosterone and estradiol in circulation.

SHBG is an essential factor in maintaining hormonal balance and has implications for several physiological processes, including sexual development, reproduction, bone health, muscle mass, and overall well-being. Abnormal SHBG levels can contribute to various medical conditions, such as hypogonadism (low testosterone levels), polycystic ovary syndrome (PCOS), and certain types of cancer.

Luteinizing Hormone (LH) is a glycoprotein hormone, which is primarily produced and released by the anterior pituitary gland. In women, a surge of LH triggers ovulation, the release of an egg from the ovaries during the menstrual cycle. During pregnancy, LH stimulates the corpus luteum to produce progesterone. In men, LH stimulates the testes to produce testosterone. It plays a crucial role in sexual development, reproduction, and maintaining the reproductive system.

Estradiol is a type of estrogen, which is a female sex hormone. It is the most potent and dominant form of estrogen in humans. Estradiol plays a crucial role in the development and maintenance of secondary sexual characteristics in women, such as breast development and regulation of the menstrual cycle. It also helps maintain bone density, protect the lining of the uterus, and is involved in cognition and mood regulation.

Estradiol is produced primarily by the ovaries, but it can also be synthesized in smaller amounts by the adrenal glands and fat cells. In men, estradiol is produced from testosterone through a process called aromatization. Abnormal levels of estradiol can contribute to various health issues, such as hormonal imbalances, infertility, osteoporosis, and certain types of cancer.

Gonadal steroid hormones, also known as gonadal sex steroids, are hormones that are produced and released by the gonads (i.e., ovaries in women and testes in men). These hormones play a critical role in the development and maintenance of secondary sexual characteristics, reproductive function, and overall health.

The three main classes of gonadal steroid hormones are:

1. Androgens: These are male sex hormones that are primarily produced by the testes but also produced in smaller amounts by the ovaries and adrenal glands. The most well-known androgen is testosterone, which plays a key role in the development of male secondary sexual characteristics such as facial hair, deepening of the voice, and increased muscle mass.
2. Estrogens: These are female sex hormones that are primarily produced by the ovaries but also produced in smaller amounts by the adrenal glands. The most well-known estrogen is estradiol, which plays a key role in the development of female secondary sexual characteristics such as breast development and the menstrual cycle.
3. Progestogens: These are hormones that are produced by the ovaries during the second half of the menstrual cycle and play a key role in preparing the uterus for pregnancy. The most well-known progestogen is progesterone, which also plays a role in maintaining pregnancy and regulating the menstrual cycle.

Gonadal steroid hormones can have significant effects on various physiological processes, including bone density, cognitive function, mood, and sexual behavior. Disorders of gonadal steroid hormone production or action can lead to a range of health problems, including infertility, osteoporosis, and sexual dysfunction.

Epitestosterone is a steroid hormone that is structurally similar to testosterone. It is produced in the body, primarily in the testes and adrenal glands, and is a natural component of human urine. Epitestosterone is a weak androgen, meaning it has minimal male sex hormone effects.

The ratio of epitestosterone to testosterone (T/E ratio) in urine is often used as a marker for the detection of doping with anabolic steroids, which are synthetic versions of testosterone. In athletes who have not taken performance-enhancing drugs, the T/E ratio is typically less than 1. However, when anabolic steroids are used, the level of testosterone in the body increases, while the level of epitestosterone remains relatively unchanged, leading to a higher T/E ratio.

Medical professionals and anti-doping agencies use a specific cutoff value for the T/E ratio to determine if an individual has violated doping regulations. It's important to note that some individuals may have naturally higher T/E ratios due to genetic factors, which can complicate the interpretation of test results in anti-doping tests.

Castration is a surgical procedure to remove the testicles in males or ovaries in females. In males, it is also known as orchiectomy. This procedure results in the inability to produce sex hormones and gametes (sperm in men and eggs in women), and can be done for various reasons such as medical treatment for certain types of cancer, to reduce sexual urges in individuals with criminal tendencies, or as a form of birth control in animals.

Androstenedione is a steroid hormone produced by the adrenal glands, ovaries, and testes. It is a precursor to both male and female sex hormones, including testosterone and estrogen. In the adrenal glands, it is produced from cholesterol through a series of biochemical reactions involving several enzymes. Androstenedione can also be converted into other steroid hormones, such as dehydroepiandrosterone (DHEA) and estrone.

In the body, androstenedione plays an important role in the development and maintenance of secondary sexual characteristics, such as facial hair and a deep voice in men, and breast development and menstrual cycles in women. It also contributes to bone density, muscle mass, and overall physical strength.

Androstenedione is available as a dietary supplement and has been marketed as a way to boost athletic performance and increase muscle mass. However, its effectiveness for these purposes is not supported by scientific evidence, and it may have harmful side effects when taken in high doses or for extended periods of time. Additionally, the use of androstenedione as a dietary supplement is banned by many sports organizations, including the International Olympic Committee and the National Collegiate Athletic Association.

Follicle-Stimulating Hormone (FSH) is a glycoprotein hormone secreted and released by the anterior pituitary gland. In females, it promotes the growth and development of ovarian follicles in the ovary, which ultimately leads to the maturation and release of an egg (ovulation). In males, FSH stimulates the testes to produce sperm. It works in conjunction with luteinizing hormone (LH) to regulate reproductive processes. The secretion of FSH is controlled by the hypothalamic-pituitary-gonadal axis and its release is influenced by the levels of gonadotropin-releasing hormone (GnRH), estrogen, inhibin, and androgens.

Flutamide is an anti-androgen medication, which is primarily used to treat prostate cancer. It works by blocking the action of androgens (male hormones), such as testosterone, on cancer cells. This helps to slow down or stop the growth of prostate cancer cells. Flutamide may be given in combination with other medications, such as a luteinizing hormone-releasing hormone (LHRH) agonist, to enhance its effectiveness. It is usually taken by mouth in the form of tablets.

Flutamide can have side effects, including breast tenderness and enlargement, hot flashes, nausea, vomiting, diarrhea, and loss of sexual desire. In rare cases, it may cause more serious side effects such as liver damage. It is important to be monitored by a healthcare professional while taking this medication to ensure that it is working properly and to manage any potential side effects.

Testosterone congeners refer to structural analogs or derivatives of testosterone, which is the primary male sex hormone and an androgen. These are compounds that have a similar chemical structure to testosterone and may exhibit similar biological activities. Testosterone congeners can be naturally occurring or synthetic and include a variety of compounds such as androgens, anabolic steroids, and estrogens. They can be used in medical treatments, but some are also misused for performance enhancement or other non-medical purposes, which can lead to various health risks and side effects.

Androgen receptors (ARs) are a type of nuclear receptor protein that are expressed in various tissues throughout the body. They play a critical role in the development and maintenance of male sexual characteristics and reproductive function. ARs are activated by binding to androgens, which are steroid hormones such as testosterone and dihydrotestosterone (DHT). Once activated, ARs function as transcription factors that regulate gene expression, ultimately leading to various cellular responses.

In the context of medical definitions, androgen receptors can be defined as follows:

Androgen receptors are a type of nuclear receptor protein that bind to androgens, such as testosterone and dihydrotestosterone, and mediate their effects on gene expression in various tissues. They play critical roles in the development and maintenance of male sexual characteristics and reproductive function, and are involved in the pathogenesis of several medical conditions, including prostate cancer, benign prostatic hyperplasia, and androgen deficiency syndromes.

Sexual maturation is the process of physical development during puberty that leads to the ability to reproduce. This process involves the development of primary and secondary sexual characteristics, changes in hormone levels, and the acquisition of reproductive capabilities. In females, this includes the onset of menstruation and the development of breasts and hips. In males, this includes the deepening of the voice, growth of facial hair, and the production of sperm. Achieving sexual maturation is an important milestone in human development and typically occurs during adolescence.

Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands. It serves as a precursor to other hormones, including androgens such as testosterone and estrogens such as estradiol. DHEA levels typically peak during early adulthood and then gradually decline with age.

DHEA has been studied for its potential effects on various health conditions, including aging, cognitive function, sexual dysfunction, and certain chronic diseases. However, the evidence supporting its use for these purposes is generally limited and inconclusive. As with any supplement or medication, it's important to consult with a healthcare provider before taking DHEA to ensure safety and effectiveness.

3-Oxo-5-alpha-steroid 4-dehydrogenase is an enzyme that plays a role in steroid metabolism. It is involved in the conversion of certain steroids into others by removing hydrogen atoms and adding oxygen to create double bonds in the steroid molecule. Specifically, this enzyme catalyzes the dehydrogenation of 3-oxo-5-alpha-steroids at the 4th position, which results in the formation of a 4,5-double bond.

The enzyme is found in various tissues throughout the body and is involved in the metabolism of several important steroid hormones, including cortisol, aldosterone, and androgens. It helps to regulate the levels of these hormones in the body by converting them into their active or inactive forms as needed.

Deficiencies or mutations in the 3-oxo-5-alpha-steroid 4-dehydrogenase enzyme can lead to various medical conditions, such as congenital adrenal hyperplasia, which is characterized by abnormal hormone levels and development of sexual characteristics.

Gonadotropin-Releasing Hormone (GnRH), also known as Luteinizing Hormone-Releasing Hormone (LHRH), is a hormonal peptide consisting of 10 amino acids. It is produced and released by the hypothalamus, an area in the brain that links the nervous system to the endocrine system via the pituitary gland.

GnRH plays a crucial role in regulating reproduction and sexual development through its control of two gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These gonadotropins, in turn, stimulate the gonads (ovaries or testes) to produce sex steroids and eggs or sperm.

GnRH acts on the anterior pituitary gland by binding to its specific receptors, leading to the release of FSH and LH. The hypothalamic-pituitary-gonadal axis is under negative feedback control, meaning that when sex steroid levels are high, they inhibit the release of GnRH, which subsequently decreases FSH and LH secretion.

GnRH agonists and antagonists have clinical applications in various medical conditions, such as infertility treatments, precocious puberty, endometriosis, uterine fibroids, prostate cancer, and hormone-responsive breast cancer.

Hormone Replacement Therapy (HRT) is a medical treatment that involves the use of hormones to replace or supplement those that the body is no longer producing or no longer producing in sufficient quantities. It is most commonly used to help manage symptoms associated with menopause and conditions related to hormonal imbalances.

In women, HRT typically involves the use of estrogen and/or progesterone to alleviate hot flashes, night sweats, vaginal dryness, and mood changes that can occur during menopause. In some cases, testosterone may also be prescribed to help improve energy levels, sex drive, and overall sense of well-being.

In men, HRT is often used to treat low testosterone levels (hypogonadism) and related symptoms such as fatigue, decreased muscle mass, and reduced sex drive.

It's important to note that while HRT can be effective in managing certain symptoms, it also carries potential risks, including an increased risk of blood clots, stroke, breast cancer (in women), and cardiovascular disease. Therefore, the decision to undergo HRT should be made carefully and discussed thoroughly with a healthcare provider.

Organ size refers to the volume or physical measurement of an organ in the body of an individual. It can be described in terms of length, width, and height or by using specialized techniques such as imaging studies (like CT scans or MRIs) to determine the volume. The size of an organ can vary depending on factors such as age, sex, body size, and overall health status. Changes in organ size may indicate various medical conditions, including growths, inflammation, or atrophy.

A drug implant is a medical device that is specially designed to provide controlled release of a medication into the body over an extended period of time. Drug implants can be placed under the skin or in various body cavities, depending on the specific medical condition being treated. They are often used when other methods of administering medication, such as oral pills or injections, are not effective or practical.

Drug implants come in various forms, including rods, pellets, and small capsules. The medication is contained within the device and is released slowly over time, either through diffusion or erosion of the implant material. This allows for a steady concentration of the drug to be maintained in the body, which can help to improve treatment outcomes and reduce side effects.

Some common examples of drug implants include:

1. Hormonal implants: These are small rods that are inserted under the skin of the upper arm and release hormones such as progestin or estrogen over a period of several years. They are often used for birth control or to treat conditions such as endometriosis or uterine fibroids.
2. Intraocular implants: These are small devices that are placed in the eye during surgery to release medication directly into the eye. They are often used to treat conditions such as age-related macular degeneration or diabetic retinopathy.
3. Bone cement implants: These are specially formulated cements that contain antibiotics and are used to fill bone defects or joint spaces during surgery. The antibiotics are released slowly over time, helping to prevent infection.
4. Implantable pumps: These are small devices that are placed under the skin and deliver medication directly into a specific body cavity, such as the spinal cord or the peritoneal cavity. They are often used to treat chronic pain or cancer.

Overall, drug implants offer several advantages over other methods of administering medication, including improved compliance, reduced side effects, and more consistent drug levels in the body. However, they may also have some disadvantages, such as the need for surgical placement and the potential for infection or other complications. As with any medical treatment, it is important to discuss the risks and benefits of drug implants with a healthcare provider.

Dehydroepiandrosterone sulfate (DHEA-S) is a steroid hormone that is produced by the adrenal glands. It is a modified form of dehydroepiandrosterone (DHEA), which is converted to DHEA-S in the body for storage and later conversion back to DHEA or other steroid hormones, such as testosterone and estrogen. DHEA-S is often measured in the blood as a marker of adrenal function. It is also available as a dietary supplement, although its effectiveness for any medical purpose is not well established.

Spermatogenesis is the process by which sperm cells, or spermatozoa, are produced in male organisms. It occurs in the seminiferous tubules of the testes and involves several stages:

1. Spermatocytogenesis: This is the initial stage where diploid spermatogonial stem cells divide mitotically to produce more spermatogonia, some of which will differentiate into primary spermatocytes.
2. Meiosis: The primary spermatocytes undergo meiotic division to form haploid secondary spermatocytes, which then divide again to form haploid spermatids. This process results in the reduction of chromosome number from 46 (diploid) to 23 (haploid).
3. Spermiogenesis: The spermatids differentiate into spermatozoa, undergoing morphological changes such as the formation of a head and tail. During this stage, most of the cytoplasm is discarded, resulting in highly compacted and streamlined sperm cells.
4. Spermation: The final stage where mature sperm are released from the seminiferous tubules into the epididymis for further maturation and storage.

The entire process takes approximately 72-74 days in humans, with continuous production throughout adulthood.

"Sex characteristics" refer to the anatomical, chromosomal, and genetic features that define males and females. These include both primary sex characteristics (such as reproductive organs like ovaries or testes) and secondary sex characteristics (such as breasts or facial hair) that typically develop during puberty. Sex characteristics are primarily determined by the presence of either X or Y chromosomes, with XX individuals usually developing as females and XY individuals usually developing as males, although variations and exceptions to this rule do occur.

Sexual behavior in animals refers to a variety of behaviors related to reproduction and mating that occur between members of the same species. These behaviors can include courtship displays, mating rituals, and various physical acts. The specific forms of sexual behavior displayed by a given species are influenced by a combination of genetic, hormonal, and environmental factors.

In some animals, sexual behavior is closely tied to reproductive cycles and may only occur during certain times of the year or under specific conditions. In other species, sexual behavior may be more frequent and less closely tied to reproduction, serving instead as a means of social bonding or communication.

It's important to note that while humans are animals, the term "sexual behavior" is often used in a more specific sense to refer to sexual activities between human beings. The study of sexual behavior in animals is an important area of research within the field of animal behavior and can provide insights into the evolutionary origins of human sexual behavior as well as the underlying mechanisms that drive it.

Radioimmunoassay (RIA) is a highly sensitive analytical technique used in clinical and research laboratories to measure concentrations of various substances, such as hormones, vitamins, drugs, or tumor markers, in biological samples like blood, urine, or tissues. The method relies on the specific interaction between an antibody and its corresponding antigen, combined with the use of radioisotopes to quantify the amount of bound antigen.

In a typical RIA procedure, a known quantity of a radiolabeled antigen (also called tracer) is added to a sample containing an unknown concentration of the same unlabeled antigen. The mixture is then incubated with a specific antibody that binds to the antigen. During the incubation period, the antibody forms complexes with both the radiolabeled and unlabeled antigens.

After the incubation, the unbound (free) radiolabeled antigen is separated from the antibody-antigen complexes, usually through a precipitation or separation step involving centrifugation, filtration, or chromatography. The amount of radioactivity in the pellet (containing the antibody-antigen complexes) is then measured using a gamma counter or other suitable radiation detection device.

The concentration of the unlabeled antigen in the sample can be determined by comparing the ratio of bound to free radiolabeled antigen in the sample to a standard curve generated from known concentrations of unlabeled antigen and their corresponding bound/free ratios. The higher the concentration of unlabeled antigen in the sample, the lower the amount of radiolabeled antigen that will bind to the antibody, resulting in a lower bound/free ratio.

Radioimmunoassays offer high sensitivity, specificity, and accuracy, making them valuable tools for detecting and quantifying low levels of various substances in biological samples. However, due to concerns about radiation safety and waste disposal, alternative non-isotopic immunoassay techniques like enzyme-linked immunosorbent assays (ELISAs) have become more popular in recent years.

Androgen antagonists are a class of drugs that block the action of androgens, which are hormones that contribute to male sexual development and characteristics. They work by binding to androgen receptors in cells, preventing the natural androgens from attaching and exerting their effects. This can be useful in treating conditions that are caused or worsened by androgens, such as prostate cancer, hirsutism (excessive hair growth in women), and acne. Examples of androgen antagonists include flutamide, bicalutamide, and spironolactone.

Chorionic Gonadotropin (hCG) is a hormone that is produced during pregnancy. It is produced by the placenta after implantation of the fertilized egg in the uterus. The main function of hCG is to prevent the disintegration of the corpus luteum, which is a temporary endocrine structure that forms in the ovary after ovulation and produces progesterone during early pregnancy. Progesterone is essential for maintaining the lining of the uterus and supporting the pregnancy.

hCG can be detected in the blood or urine as early as 10 days after conception, and its levels continue to rise throughout the first trimester of pregnancy. In addition to its role in maintaining pregnancy, hCG is also used as a clinical marker for pregnancy and to monitor certain medical conditions such as gestational trophoblastic diseases.

Aromatase is a enzyme that belongs to the cytochrome P450 superfamily, and it is responsible for converting androgens into estrogens through a process called aromatization. This enzyme plays a crucial role in the steroid hormone biosynthesis pathway, particularly in females where it is primarily expressed in adipose tissue, ovaries, brain, and breast tissue.

Aromatase inhibitors are used as a treatment for estrogen receptor-positive breast cancer in postmenopausal women, as they work by blocking the activity of aromatase and reducing the levels of circulating estrogens in the body.

The prostate is a small gland that is part of the male reproductive system. Its main function is to produce a fluid that, together with sperm cells from the testicles and fluids from other glands, makes up semen. This fluid nourishes and protects the sperm, helping it to survive and facilitating its movement.

The prostate is located below the bladder and in front of the rectum. It surrounds part of the urethra, the tube that carries urine and semen out of the body. This means that prostate problems can affect urination and sexual function. The prostate gland is about the size of a walnut in adult men.

Prostate health is an important aspect of male health, particularly as men age. Common prostate issues include benign prostatic hyperplasia (BPH), which is an enlarged prostate not caused by cancer, and prostate cancer, which is one of the most common types of cancer in men. Regular check-ups with a healthcare provider can help to detect any potential problems early and improve outcomes.

Progesterone is a steroid hormone that is primarily produced in the ovaries during the menstrual cycle and in pregnancy. It plays an essential role in preparing the uterus for implantation of a fertilized egg and maintaining the early stages of pregnancy. Progesterone works to thicken the lining of the uterus, creating a nurturing environment for the developing embryo.

During the menstrual cycle, progesterone is produced by the corpus luteum, a temporary structure formed in the ovary after an egg has been released from a follicle during ovulation. If pregnancy does not occur, the levels of progesterone will decrease, leading to the shedding of the uterine lining and menstruation.

In addition to its reproductive functions, progesterone also has various other effects on the body, such as helping to regulate the immune system, supporting bone health, and potentially influencing mood and cognition. Progesterone can be administered medically in the form of oral pills, intramuscular injections, or vaginal suppositories for various purposes, including hormone replacement therapy, contraception, and managing certain gynecological conditions.

Libido, in medical and psychological terms, refers to a person's overall sexual drive or desire for sexual activity. This term was first introduced by Sigmund Freud in his psychoanalytic theory, where he described it as one of the three components of human personality. Libido is influenced by biological, psychological, and social factors, and can vary significantly among individuals. It's important to note that a low or absent libido does not necessarily indicate an underlying medical issue, but could be a result of various factors such as stress, fatigue, relationship issues, mental health disorders, or hormonal imbalances. If you have concerns about your libido, it is recommended to consult with a healthcare professional for a proper evaluation and guidance.

Hirsutism is a medical condition characterized by excessive hair growth in women in areas where hair growth is typically androgen-dependent, such as the face, chest, lower abdomen, and inner thighs. This hair growth is often thick, dark, and coarse, resembling male-pattern hair growth. Hirsutism can be caused by various factors, including hormonal imbalances, certain medications, and genetic conditions. It's essential to consult a healthcare professional if you experience excessive or unwanted hair growth to determine the underlying cause and develop an appropriate treatment plan.

Androstanes are a class of steroidal compounds that have a basic structure consisting of a four-ring core derived from cholesterol. Specifically, androstanes contain a 19-carbon skeleton with a chemical formula of C19H28O or C19H28O2, depending on whether they are alcohols (androgens) or ketones (androstanes), respectively.

The term "androstane" is often used to refer to the parent compound, which has a hydroxyl group (-OH) attached at the C3 position of the steroid nucleus. When this hydroxyl group is replaced by a keto group (-C=O), the resulting compound is called androstane-3,17-dione or simply "androstane."

Androstanes are important precursors in the biosynthesis of various steroid hormones, including testosterone, estrogen, and cortisol. They are also used as intermediates in the synthesis of certain drugs and pharmaceuticals.

Virilism is a condition that results from excessive exposure to androgens (male hormones) such as testosterone. It can occur in both males and females, but it is more noticeable in women and children. In females, virilism can cause various masculinizing features like excess body hair, deepened voice, enlarged clitoris, and irregular menstrual cycles. In children, it can lead to premature puberty and growth abnormalities. Virilism is often caused by conditions that involve the adrenal glands or ovaries, including tumors, congenital adrenal hyperplasia, and certain medications.

"Male genitalia" refers to the reproductive and sexual organs that are typically present in male individuals. These structures include:

1. Testes: A pair of oval-shaped glands located in the scrotum that produce sperm and testosterone.
2. Epididymis: A long, coiled tube that lies on the surface of each testicle where sperm matures and is stored.
3. Vas deferens: A pair of muscular tubes that transport sperm from the epididymis to the urethra.
4. Seminal vesicles: Glands that produce a fluid that mixes with sperm to create semen.
5. Prostate gland: A small gland that surrounds the urethra and produces a fluid that also mixes with sperm to create semen.
6. Bulbourethral glands (Cowper's glands): Two pea-sized glands that produce a lubricating fluid that is released into the urethra during sexual arousal.
7. Urethra: A tube that runs through the penis and carries urine from the bladder out of the body, as well as semen during ejaculation.
8. Penis: The external organ that serves as both a reproductive and excretory organ, expelling both semen and urine.

Cyproterone is an anti-androgen medication that works by blocking the action of androgens (male hormones such as testosterone) in the body. It is used to treat conditions such as prostate cancer, hirsutism (excessive hair growth), and severe acne that have not responded to other treatments. Cyproterone is also used in conjunction with estrogen therapy to help reduce sexual desire in individuals with paraphilic disorders or gender identity disorder.

The medication comes in the form of tablets and is usually taken once or twice a day, depending on the condition being treated. Common side effects of cyproterone include breast tenderness, decreased sex drive, and irregular menstrual periods. More serious side effects may include liver damage, blood clots, and an increased risk of certain types of cancer.

It is important to follow the instructions of a healthcare provider when taking cyproterone, as the medication can interact with other medications and have potentially serious side effects. Regular monitoring by a healthcare provider is also necessary to ensure that the medication is working effectively and to monitor for any potential side effects.

Sperm count, also known as sperm concentration, is the number of sperm present in a given volume of semen. The World Health Organization (WHO) previously defined a normal sperm count as at least 20 million sperm per milliliter of semen. However, more recent studies suggest that fertility may be affected even when sperm counts are slightly lower than this threshold. It's important to note that sperm count is just one factor among many that can influence male fertility. Other factors, such as sperm motility (the ability of sperm to move properly) and morphology (the shape of the sperm), also play crucial roles in successful conception.

Gonadotropins are hormones produced and released by the anterior pituitary gland, a small endocrine gland located at the base of the brain. These hormones play crucial roles in regulating reproduction and sexual development. There are two main types of gonadotropins:

1. Follicle-Stimulating Hormone (FSH): FSH is essential for the growth and development of follicles in the ovaries (in females) or sperm production in the testes (in males). In females, FSH stimulates the maturation of eggs within the follicles.
2. Luteinizing Hormone (LH): LH triggers ovulation in females, causing the release of a mature egg from the dominant follicle. In males, LH stimulates the production and secretion of testosterone in the testes.

Together, FSH and LH work synergistically to regulate various aspects of reproductive function and sexual development. Their secretion is controlled by the hypothalamus, which releases gonadotropin-releasing hormone (GnRH) to stimulate the production and release of FSH and LH from the anterior pituitary gland.

Abnormal levels of gonadotropins can lead to various reproductive disorders, such as infertility or menstrual irregularities in females and issues related to sexual development or function in both sexes. In some cases, synthetic forms of gonadotropins may be used clinically to treat these conditions or for assisted reproductive technologies (ART).

Steroids, also known as corticosteroids, are a type of hormone that the adrenal gland produces in your body. They have many functions, such as controlling the balance of salt and water in your body and helping to reduce inflammation. Steroids can also be synthetically produced and used as medications to treat a variety of conditions, including allergies, asthma, skin conditions, and autoimmune disorders.

Steroid medications are available in various forms, such as oral pills, injections, creams, and inhalers. They work by mimicking the effects of natural hormones produced by your body, reducing inflammation and suppressing the immune system's response to prevent or reduce symptoms. However, long-term use of steroids can have significant side effects, including weight gain, high blood pressure, osteoporosis, and increased risk of infections.

It is important to note that anabolic steroids are a different class of drugs that are sometimes abused for their muscle-building properties. These steroids are synthetic versions of the male hormone testosterone and can have serious health consequences when taken in large doses or without medical supervision.

The seminal vesicles are a pair of glands located in the male reproductive system, posterior to the urinary bladder and superior to the prostate gland. They are approximately 5 cm long and have a convoluted structure with many finger-like projections called infoldings. The primary function of seminal vesicles is to produce and secrete a significant portion of the seminal fluid, which makes up the bulk of semen along with spermatozoa from the testes and fluids from the prostate gland and bulbourethral glands.

The secretion of the seminal vesicles is rich in fructose, which serves as an energy source for sperm, as well as various proteins, enzymes, vitamins, and minerals that contribute to maintaining the optimal environment for sperm survival, nourishment, and transport. During sexual arousal and ejaculation, the smooth muscles in the walls of the seminal vesicles contract, forcing the stored secretion into the urethra, where it mixes with other fluids before being expelled from the body as semen.

Hormones are defined as chemical messengers that are produced by endocrine glands or specialized cells and are transported through the bloodstream to tissues and organs, where they elicit specific responses. They play crucial roles in regulating various physiological processes such as growth, development, metabolism, reproduction, and mood. Examples of hormones include insulin, estrogen, testosterone, adrenaline, and thyroxine.

Androstane-3,17-diol is a steroid hormone, specifically a 17-ketosteroid, that is synthesized from the metabolism of androgens such as testosterone. It exists in two forms: 5α-androstane-3α,17β-diol and 5β-androstane-3α,17β-diol, which differ based on the configuration of the A ring at the 5 position. These compounds are weak androgens themselves but serve as important intermediates in steroid hormone metabolism. They can be further metabolized to form other steroid hormones or their metabolites, such as androstanediol glucuronide, which is a major urinary metabolite of testosterone and dihydrotestosterone.

17-Hydroxysteroid dehydrogenases (17-HSDs) are a group of enzymes that play a crucial role in steroid hormone biosynthesis. They are involved in the conversion of 17-ketosteroids to 17-hydroxy steroids or vice versa, by adding or removing a hydroxyl group (–OH) at the 17th carbon atom of the steroid molecule. This conversion is essential for the production of various steroid hormones, including cortisol, aldosterone, and sex hormones such as estrogen and testosterone.

There are several isoforms of 17-HSDs, each with distinct substrate specificities, tissue distributions, and functions:

1. 17-HSD type 1 (17-HSD1): This isoform primarily catalyzes the conversion of estrone (E1) to estradiol (E2), an active form of estrogen. It is mainly expressed in the ovary, breast, and adipose tissue.
2. 17-HSD type 2 (17-HSD2): This isoform catalyzes the reverse reaction, converting estradiol (E2) to estrone (E1). It is primarily expressed in the placenta, prostate, and breast tissue.
3. 17-HSD type 3 (17-HSD3): This isoform is responsible for the conversion of androstenedione to testosterone, an essential step in male sex hormone biosynthesis. It is predominantly expressed in the testis and adrenal gland.
4. 17-HSD type 4 (17-HSD4): This isoform catalyzes the conversion of dehydroepiandrosterone (DHEA) to androstenedione, an intermediate step in steroid hormone biosynthesis. It is primarily expressed in the placenta.
5. 17-HSD type 5 (17-HSD5): This isoform catalyzes the conversion of cortisone to cortisol, a critical step in glucocorticoid biosynthesis. It is predominantly expressed in the adrenal gland and liver.
6. 17-HSD type 6 (17-HSD6): This isoform catalyzes the conversion of androstenedione to testosterone, similar to 17-HSD3. However, it has a different substrate specificity and is primarily expressed in the ovary.
7. 17-HSD type 7 (17-HSD7): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the ovary.
8. 17-HSD type 8 (17-HSD8): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
9. 17-HSD type 9 (17-HSD9): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
10. 17-HSD type 10 (17-HSD10): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
11. 17-HSD type 11 (17-HSD11): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
12. 17-HSD type 12 (17-HSD12): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
13. 17-HSD type 13 (17-HSD13): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
14. 17-HSD type 14 (17-HSD14): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
15. 17-HSD type 15 (17-HSD15): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
16. 17-HSD type 16 (17-HSD16): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
17. 17-HSD type 17 (17-HSD17): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
18. 17-HSD type 18 (17-HSD18): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
19. 17-HSD type 19 (17-HSD19): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
20. 17-HSD type 20 (17-HSD20): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
21. 17-HSD type 21 (17-HSD21): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
22. 17-HSD type 22 (17-HSD22): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
23. 17-HSD type 23 (17-HSD23): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
24. 17-HSD type 24 (17-HSD24): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However, it has a different substrate specificity and is primarily expressed in the testis.
25. 17-HSD type 25 (17-HSD25): This isoform catalyzes the conversion of estrone (E1) to estradiol (E2), similar to 17-HSD1. However, it has a different substrate specificity and is primarily expressed in the placenta.
26. 17-HSD type 26 (17-HSD26): This isoform catalyzes the conversion of DHEA to androstenedione, similar to 17-HSD4. However

Androsterone is a weak androgen and an endogenous steroid hormone. It's produced in the liver from dehydroepiandrosterone (DHEA) and is converted into androstenedione, another weak androgen. Androsterone is excreted in urine as a major metabolite of testosterone. It plays a role in male sexual development and function, although its effects are much weaker than those of testosterone. In clinical contexts, androsterone levels may be measured to help diagnose certain hormonal disorders or to monitor hormone therapy.

Cyproterone acetate is a synthetic steroid hormone with anti-androgen and progestogenic properties. It works by blocking the action of androgens (male sex hormones) in the body, which helps to reduce symptoms associated with excessive androgen production such as severe acne or hirsutism (excessive hair growth).

Cyproterone acetate is used in the treatment of conditions such as prostate cancer, where it can help to slow the growth of cancer cells by reducing the levels of androgens in the body. It is also used in the treatment of sexual deviations, such as pedophilia or exhibitionism, as it can reduce sexual desire.

In addition, cyproterone acetate is sometimes used in combination with estrogen in hormone replacement therapy for transgender women to suppress the production of testosterone and promote feminization.

It's important to note that cyproterone acetate can have significant side effects and its use should be under the close supervision of a healthcare professional.

17-Ketosteroids are a group of steroid compounds that contain a ketone group at the 17th carbon position in their molecular structure. They are produced as metabolic byproducts of certain hormones, such as androgens and estrogens, in the human body.

The term "17-KS" or "17-ketosteroids" is often used to refer to a class of urinary steroid metabolites that can be measured in the urine to assess adrenal and gonadal function. The measurement of 17-KS is particularly useful in monitoring patients with certain endocrine disorders, such as congenital adrenal hyperplasia or adrenal tumors.

The two major 17-KS that are routinely measured in urine are androsterone and etiocholanolone, which are derived from the metabolism of testosterone and dehydroepiandrosterone (DHEA), respectively. Other 17-KS include tetrahydrocortisone, tetrahydrocortisol, and 5-androstene-3β,17β-diol.

It's worth noting that the measurement of 17-KS has largely been replaced by more specific tests, such as the measurement of individual steroid hormones or their metabolites using mass spectrometry-based methods.

5-alpha Reductase Inhibitors are a class of drugs that block the action of the enzyme 5-alpha reductase, which is responsible for converting testosterone to dihydrotestosterone (DHT). DHT is a more potent form of testosterone that plays a key role in the development and maintenance of male sexual characteristics and is involved in the pathogenesis of benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern baldness).

By inhibiting the action of 5-alpha reductase, these drugs reduce the levels of DHT in the body, which can help to shrink the prostate gland and improve symptoms of BPH such as difficulty urinating, frequent urination, and weak urine stream. They are also used off-label to treat hair loss in men.

Examples of 5-alpha reductase inhibitors include finasteride (Proscar, Propecia) and dutasteride (Avodart). Common side effects of these drugs may include decreased libido, erectile dysfunction, and breast tenderness or enlargement.

17-α-Hydroxyprogesterone is a naturally occurring hormone produced by the adrenal glands and, in smaller amounts, by the ovaries and testes. It is an intermediate in the biosynthesis of steroid hormones, including cortisol, aldosterone, and sex hormones such as testosterone and estrogen.

In a medical context, 17-α-Hydroxyprogesterone may also refer to a synthetic form of this hormone that is used in the treatment of certain medical conditions. For example, a medication called 17-alpha-hydroxyprogesterone caproate (17-OHP) is used to reduce the risk of preterm birth in women who have previously given birth prematurely. It works by suppressing uterine contractions and promoting fetal lung maturity.

It's important to note that 17-alpha-Hydroxyprogesterone should only be used under the supervision of a healthcare provider, as it can have side effects and may interact with other medications.

Contraceptive agents for males are substances or methods that are used to prevent pregnancy by reducing the likelihood of fertilization. These can include:

1. Barrier methods: Condoms, diaphragms, and spermicides create a physical barrier that prevents sperm from reaching the egg.
2. Hormonal methods: Testosterone and progestin hormone therapies can decrease sperm production and reduce fertility.
3. Intrauterine devices (IUDs) for men: These are still in the experimental stage, but they involve placing a device in the male reproductive tract to prevent sperm from reaching the female reproductive system.
4. Withdrawal method: This involves the man withdrawing his penis from the vagina before ejaculation, although this is not a highly reliable form of contraception.
5. Fertility awareness methods: These involve tracking the woman's menstrual cycle and avoiding sexual intercourse during her fertile period.
6. Sterilization: Vasectomy is a surgical procedure that blocks or cuts the vas deferens, preventing sperm from leaving the body. It is a permanent form of contraception for men.

It's important to note that no contraceptive method is 100% effective, and individuals should consult with their healthcare provider to determine which option is best for them based on their personal needs, lifestyle, and medical history.

Cholestenone 5 alpha-reductase is an enzyme that plays a role in the conversion of cholesterol and other steroid hormones in the body. Specifically, it catalyzes the reduction of 5,7-dihydroxycholest-4-en-3-one (also known as cholestenone) to 5α-androstan-3α,17β-diol, which is a precursor to the male sex hormone testosterone.

This enzyme is found in various tissues throughout the body, including the prostate gland, skin, and liver. In the prostate gland, 5 alpha-reductase helps regulate the growth and function of the gland by converting testosterone to dihydrotestosterone (DHT), a more potent form of the hormone.

Inhibitors of 5 alpha-reductase are sometimes used as medications to treat conditions such as benign prostatic hyperplasia (BPH) and male pattern baldness, as reducing DHT levels can help alleviate symptoms associated with these conditions.

I believe there might be a slight misunderstanding in your question. There is no such term as "Hydroxytestosterones" in medical or scientific literature. However, I can provide you with information about a related topic: Hydroxylation of Testosterone.

Testosterone, a natural androgenic steroid hormone, can undergo hydroxylation - the addition of a hydroxyl group (-OH) - at various positions in its chemical structure. These modified forms of testosterone are involved in different physiological processes and metabolic pathways in the body. Some examples include:

1. 6α-Hydroxytestosterone: A minor metabolite formed through the action of the enzyme 3β-hydroxysteroid dehydrogenase/δ5-4 isomerase (3β-HSD). Its role and significance in human physiology are not well understood.
2. 7α-Hydroxytestosterone: A minor metabolite formed through the action of the enzyme 7α-hydroxylase, which is primarily involved in bile acid synthesis.
3. 16α-Hydroxytestosterone: A metabolite that can be formed through the action of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD). This compound has been studied in relation to its potential role in breast cancer development and progression.
4. 2α,3α-Dihydroxytestosterone (Allotetrahydrocortisol): A metabolite formed through the action of the enzyme 5α-reductase and 3α-hydroxysteroid dehydrogenase (3α-HSD). This compound is a minor metabolite in humans, but it plays a significant role in the metabolism of cortisol.

It's important to note that these hydroxylated forms of testosterone are typically present in much lower concentrations compared to testosterone itself and have distinct physiological roles.

Leuprolide is a synthetic hormonal analog of gonadotropin-releasing hormone (GnRH or LHRH). It acts as a potent agonist of GnRH receptors, leading to the suppression of pituitary gland's secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This, in turn, results in decreased levels of sex hormones such as testosterone and estrogen.

Leuprolide is used clinically for the treatment of various conditions related to hormonal imbalances, including:
- Prostate cancer: Leuprolide can help slow down the growth of prostate cancer cells by reducing testosterone levels in the body.
- Endometriosis: By lowering estrogen levels, leuprolide can alleviate symptoms associated with endometriosis such as pelvic pain and menstrual irregularities.
- Central precocious puberty: Leuprolide is used to delay the onset of puberty in children who experience it prematurely by inhibiting the release of gonadotropins.
- Uterine fibroids: Lowering estrogen levels with leuprolide can help shrink uterine fibroids and reduce symptoms like heavy menstrual bleeding and pelvic pain.

Leuprolide is available in various formulations, such as injectable depots or implants, for long-term hormonal suppression. Common side effects include hot flashes, mood changes, and potential loss of bone density due to prolonged hormone suppression.

Sertoli cells, also known as sustentacular cells or nurse cells, are specialized cells in the seminiferous tubules of the testis in mammals. They play a crucial role in supporting and nurturing the development of sperm cells (spermatogenesis). Sertoli cells create a microenvironment within the seminiferous tubules that facilitates the differentiation, maturation, and survival of germ cells.

These cells have several essential functions:

1. Blood-testis barrier formation: Sertoli cells form tight junctions with each other, creating a physical barrier called the blood-testis barrier, which separates the seminiferous tubules into basal and adluminal compartments. This barrier protects the developing sperm cells from the immune system and provides an isolated environment for their maturation.
2. Nutrition and support: Sertoli cells provide essential nutrients and growth factors to germ cells, ensuring their proper development and survival. They also engulf and digest residual bodies, which are byproducts of spermatid differentiation.
3. Phagocytosis: Sertoli cells have phagocytic properties, allowing them to remove debris and dead cells within the seminiferous tubules.
4. Hormone metabolism: Sertoli cells express receptors for various hormones, such as follicle-stimulating hormone (FSH), testosterone, and estradiol. They play a role in regulating hormonal signaling within the testis by metabolizing these hormones or producing inhibins, which modulate FSH secretion from the pituitary gland.
5. Regulation of spermatogenesis: Sertoli cells produce and secrete various proteins and growth factors that influence germ cell development and proliferation. They also control the release of mature sperm cells into the epididymis through a process called spermiation.

Seminiferous tubules are the long, convoluted tubes within the testicles that are responsible for producing sperm in males. They are lined with specialized epithelial cells called Sertoli cells, which provide structural support and nourishment to developing sperm cells. The seminiferous tubules also contain germ cells, which divide and differentiate into spermatozoa (sperm) through the process of spermatogenesis.

The seminiferous tubules are surrounded by a thin layer of smooth muscle called the tunica albuginea, which helps to maintain the structure and integrity of the testicle. The tubules are connected to the rete testis, a network of channels that transport sperm to the epididymis for further maturation and storage before ejaculation.

Damage or dysfunction of the seminiferous tubules can lead to male infertility, as well as other reproductive health issues.

Estrogens are a group of steroid hormones that are primarily responsible for the development and regulation of female sexual characteristics and reproductive functions. They are also present in lower levels in males. The main estrogen hormone is estradiol, which plays a key role in promoting the growth and development of the female reproductive system, including the uterus, fallopian tubes, and breasts. Estrogens also help regulate the menstrual cycle, maintain bone density, and have important effects on the cardiovascular system, skin, hair, and cognitive function.

Estrogens are produced primarily by the ovaries in women, but they can also be produced in smaller amounts by the adrenal glands and fat cells. In men, estrogens are produced from the conversion of testosterone, the primary male sex hormone, through a process called aromatization.

Estrogen levels vary throughout a woman's life, with higher levels during reproductive years and lower levels after menopause. Estrogen therapy is sometimes used to treat symptoms of menopause, such as hot flashes and vaginal dryness, or to prevent osteoporosis in postmenopausal women. However, estrogen therapy also carries risks, including an increased risk of certain cancers, blood clots, and stroke, so it is typically recommended only for women who have a high risk of these conditions.

Gonadotropins are hormones that stimulate the gonads (sex glands) to produce sex steroids and gametes (sex cells). In humans, there are two main types of gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are produced and released by the anterior pituitary gland.

FSH plays a crucial role in the development and maturation of ovarian follicles in females and sperm production in males. LH triggers ovulation in females, causing the release of a mature egg from the ovary, and stimulates testosterone production in males.

Gonadotropins are often used in medical treatments to stimulate the gonads, such as in infertility therapies where FSH and LH are administered to induce ovulation or increase sperm production.

Estrone is a type of estrogen, which is a female sex hormone. It's one of the three major naturally occurring estrogens in women, along with estradiol and estriol. Estrone is weaker than estradiol but has a longer half-life, meaning it remains active in the body for a longer period of time.

Estrone is produced primarily in the ovaries, adrenal glands, and fat tissue. In postmenopausal women, when the ovaries stop producing estradiol, estrone becomes the dominant form of estrogen. It plays a role in maintaining bone density, regulating the menstrual cycle, and supporting the development and maintenance of female sexual characteristics.

Like other forms of estrogen, estrone can also have effects on various tissues throughout the body, including the brain, heart, and breast tissue. Abnormal levels of estrone, either too high or too low, can contribute to a variety of health issues, such as osteoporosis, menstrual irregularities, and increased risk of certain types of cancer.

"Cutaneous administration" is a route of administering medication or treatment through the skin. This can be done through various methods such as:

1. Topical application: This involves applying the medication directly to the skin in the form of creams, ointments, gels, lotions, patches, or solutions. The medication is absorbed into the skin and enters the systemic circulation slowly over a period of time. Topical medications are often used for local effects, such as treating eczema, psoriasis, or fungal infections.

2. Iontophoresis: This method uses a mild electrical current to help a medication penetrate deeper into the skin. A positive charge is applied to a medication with a negative charge, or vice versa, causing it to be attracted through the skin. Iontophoresis is often used for local pain management and treating conditions like hyperhidrosis (excessive sweating).

3. Transdermal delivery systems: These are specialized patches that contain medication within them. The patch is applied to the skin, and as time passes, the medication is released through the skin and into the systemic circulation. This method allows for a steady, controlled release of medication over an extended period. Common examples include nicotine patches for smoking cessation and hormone replacement therapy patches.

Cutaneous administration offers several advantages, such as avoiding first-pass metabolism (which can reduce the effectiveness of oral medications), providing localized treatment, and allowing for self-administration in some cases. However, it may not be suitable for all types of medications or conditions, and potential side effects include skin irritation, allergic reactions, and systemic absorption leading to unwanted systemic effects.

Nandrolone is a synthetic anabolic-androgenic steroid, which is a type of hormone that is similar to testosterone. It is often used in medical settings for the treatment of certain conditions such as muscle wasting diseases, osteoporosis, and breast cancer in women. Nandrolone promotes muscle growth and increases appetite, which can help individuals with muscle wasting diseases or other conditions that cause muscle loss to maintain their strength and weight.

Nandrolone is also known by its brand names Deca-Durabolin and Durabolin. It works by increasing the production of proteins in the body, which helps to build muscle mass. Nandrolone can have both anabolic (muscle-building) and androgenic (masculinizing) effects, although it is generally considered to be less androgenic than testosterone.

Like other anabolic steroids, nandrolone can have a number of side effects, including acne, hair loss, liver damage, and mood changes. It can also cause virilization in women, which refers to the development of male characteristics such as a deep voice, facial hair, and a decrease in breast size. Nandrolone is classified as a controlled substance in many countries due to its potential for abuse and dependence.

3-Hydroxysteroid dehydrogenases (3-HSDs) are a group of enzymes that play a crucial role in steroid hormone biosynthesis. These enzymes catalyze the conversion of 3-beta-hydroxy steroids to 3-keto steroids, which is an essential step in the production of various steroid hormones, including progesterone, cortisol, aldosterone, and sex hormones such as testosterone and estradiol.

There are several isoforms of 3-HSDs that are expressed in different tissues and have distinct substrate specificities. For instance, 3-HSD type I is primarily found in the ovary and adrenal gland, where it catalyzes the conversion of pregnenolone to progesterone and 17-hydroxyprogesterone to 17-hydroxycortisol. On the other hand, 3-HSD type II is mainly expressed in the testes, adrenal gland, and placenta, where it catalyzes the conversion of dehydroepiandrosterone (DHEA) to androstenedione and androstenedione to testosterone.

Defects in 3-HSDs can lead to various genetic disorders that affect steroid hormone production and metabolism, resulting in a range of clinical manifestations such as adrenal insufficiency, ambiguous genitalia, and sexual development disorders.

The pituitary gland is a small, endocrine gland located at the base of the brain, in the sella turcica of the sphenoid bone. It is often called the "master gland" because it controls other glands and makes the hormones that trigger many body functions. The pituitary gland measures about 0.5 cm in height and 1 cm in width, and it weighs approximately 0.5 grams.

The pituitary gland is divided into two main parts: the anterior lobe (adenohypophysis) and the posterior lobe (neurohypophysis). The anterior lobe is further divided into three zones: the pars distalis, pars intermedia, and pars tuberalis. Each part of the pituitary gland has distinct functions and produces different hormones.

The anterior pituitary gland produces and releases several important hormones, including:

* Growth hormone (GH), which regulates growth and development in children and helps maintain muscle mass and bone strength in adults.
* Thyroid-stimulating hormone (TSH), which controls the production of thyroid hormones by the thyroid gland.
* Adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol and other steroid hormones.
* Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which regulate reproductive function in both males and females.
* Prolactin, which stimulates milk production in pregnant and lactating women.

The posterior pituitary gland stores and releases two hormones that are produced by the hypothalamus:

* Antidiuretic hormone (ADH), which helps regulate water balance in the body by controlling urine production.
* Oxytocin, which stimulates uterine contractions during childbirth and milk release during breastfeeding.

Overall, the pituitary gland plays a critical role in maintaining homeostasis and regulating various bodily functions, including growth, development, metabolism, and reproductive function.

Inhibins are a group of protein hormones that play a crucial role in regulating the function of the reproductive system, specifically by inhibiting the production of follicle-stimulating hormone (FSH) in the pituitary gland. They are produced and secreted primarily by the granulosa cells in the ovaries of females and Sertoli cells in the testes of males.

Inhibins consist of two subunits, an alpha subunit, and a beta subunit, which can be further divided into two types: inhibin A and inhibin B. Inhibin A is primarily produced by the granulosa cells of developing follicles in the ovary, while inhibin B is mainly produced by the Sertoli cells in the testes.

By regulating FSH production, inhibins help control the development and maturation of ovarian follicles in females and spermatogenesis in males. Abnormal levels of inhibins have been associated with various reproductive disorders, including polycystic ovary syndrome (PCOS) and certain types of cancer.

Steroid 17-alpha-hydroxylase, also known as CYP17A1, is a cytochrome P450 enzyme that plays a crucial role in steroid hormone biosynthesis. It is located in the endoplasmic reticulum of cells in the adrenal glands and gonads. This enzyme catalyzes the 17-alpha-hydroxylation and subsequent lyase cleavage of pregnenolone and progesterone, converting them into dehydroepiandrosterone (DHEA) and androstenedione, respectively. These steroid intermediates are essential for the biosynthesis of both glucocorticoids and sex steroids, including cortisol, aldosterone, estrogens, and testosterone.

Defects in the CYP17A1 gene can lead to several disorders, such as congenital adrenal hyperplasia (CAH) due to 17-alpha-hydroxylase deficiency, which is characterized by decreased production of cortisol and sex steroids and increased mineralocorticoid levels. This condition results in sexual infantilism, electrolyte imbalances, and hypertension.

Polycyctic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by the presence of hyperandrogenism (excess male hormones), ovulatory dysfunction, and polycystic ovaries. The Rotterdam criteria are commonly used for diagnosis, which require at least two of the following three features:

1. Oligo- or anovulation (irregular menstrual cycles)
2. Clinical and/or biochemical signs of hyperandrogenism (e.g., hirsutism, acne, or high levels of androgens in the blood)
3. Polycystic ovaries on ultrasound examination (presence of 12 or more follicles measuring 2-9 mm in diameter, or increased ovarian volume >10 mL)

The exact cause of PCOS remains unclear, but it is believed to involve a combination of genetic and environmental factors. Insulin resistance and obesity are common findings in women with PCOS, which can contribute to the development of metabolic complications such as type 2 diabetes, dyslipidemia, and cardiovascular disease.

Management of PCOS typically involves a multidisciplinary approach that includes lifestyle modifications (diet, exercise, weight loss), medications to regulate menstrual cycles and reduce hyperandrogenism (e.g., oral contraceptives, metformin, anti-androgens), and fertility treatments if desired. Regular monitoring of metabolic parameters and long-term follow-up are essential for optimal management and prevention of complications.

I'm sorry for any confusion, but "seasons" is not a term that has a medical definition. Seasons refer to the four divisions of the year (spring, summer, autumn or fall, and winter) based on the position of the earth in its orbit around the sun. If you have any questions related to health or medicine, I'd be happy to try to help answer those!

Prolactin is a hormone produced by the pituitary gland, a small gland located at the base of the brain. Its primary function is to stimulate milk production in women after childbirth, a process known as lactation. However, prolactin also plays other roles in the body, including regulating immune responses, metabolism, and behavior. In men, prolactin helps maintain the sexual glands and contributes to paternal behaviors.

Prolactin levels are usually low in both men and non-pregnant women but increase significantly during pregnancy and after childbirth. Various factors can affect prolactin levels, including stress, sleep, exercise, and certain medications. High prolactin levels can lead to medical conditions such as amenorrhea (absence of menstruation), galactorrhea (spontaneous milk production not related to childbirth), infertility, and reduced sexual desire in both men and women.

Aging is a complex, progressive and inevitable process of bodily changes over time, characterized by the accumulation of cellular damage and degenerative changes that eventually lead to increased vulnerability to disease and death. It involves various biological, genetic, environmental, and lifestyle factors that contribute to the decline in physical and mental functions. The medical field studies aging through the discipline of gerontology, which aims to understand the underlying mechanisms of aging and develop interventions to promote healthy aging and extend the human healthspan.

Hyperandrogenism is a medical condition characterized by excessive levels of androgens (male sex hormones) in the body. This can lead to various symptoms such as hirsutism (excessive hair growth), acne, irregular menstrual periods, and infertility in women. It can be caused by conditions like polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, and tumors in the ovaries or adrenal glands. Proper diagnosis and management of hyperandrogenism is important to prevent complications and improve quality of life.

Finasteride is a synthetic 4-azasteroid compound that acts as a specific inhibitor of Type II 5α-reductase, an intracellular enzyme that converts testosterone to dihydrotestosterone (DHT). DHT is a hormonal byproduct thought to be responsible for the development and worsening of benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA), also known as male pattern baldness.

Finasteride is available in two formulations: finasteride 1 mg (Proscar) and finasteride 5 mg (Propecia). Finasteride 1 mg is used to treat BPH, while finasteride 5 mg is used for the treatment of AGA in men. The drug works by reducing the production of DHT, which in turn slows down the progression of BPH and AGA.

It's important to note that finasteride is not approved for use in women or children, and it should be used with caution in men due to potential side effects such as decreased sexual desire, difficulty in achieving an erection, and a decrease in the amount of semen produced.

Anabolic agents are a class of drugs that promote anabolism, the building up of body tissues. These agents are often used medically to help people with certain medical conditions such as muscle wasting diseases, osteoporosis, and delayed puberty. Anabolic steroids are one type of anabolic agent. They mimic the effects of testosterone, the male sex hormone, leading to increased muscle mass and strength. However, anabolic steroids also have significant side effects and can be addictive. Therefore, their use is regulated and they are only available by prescription in many countries. Abuse of anabolic steroids for non-medical purposes, such as to improve athletic performance or appearance, is illegal and can lead to serious health consequences.

The epididymis is a tightly coiled tube located on the upper and posterior portion of the testicle that serves as the site for sperm maturation and storage. It is an essential component of the male reproductive system. The epididymis can be divided into three parts: the head (where newly produced sperm enter from the testicle), the body, and the tail (where mature sperm exit and are stored). Any abnormalities or inflammation in the epididymis may lead to discomfort, pain, or infertility.

Reproduction, in the context of biology and medicine, refers to the process by which organisms produce offspring. It is a complex process that involves the creation, development, and growth of new individuals from parent organisms. In sexual reproduction, this process typically involves the combination of genetic material from two parents through the fusion of gametes (sex cells) such as sperm and egg cells. This results in the formation of a zygote, which then develops into a new individual with a unique genetic makeup.

In contrast, asexual reproduction does not involve the fusion of gametes and can occur through various mechanisms such as budding, fragmentation, or parthenogenesis. Asexual reproduction results in offspring that are genetically identical to the parent organism.

Reproduction is a fundamental process that ensures the survival and continuation of species over time. It is also an area of active research in fields such as reproductive medicine, where scientists and clinicians work to understand and address issues related to human fertility, contraception, and genetic disorders.

Hydrocortisone is a synthetic glucocorticoid, which is a class of steroid hormones. It is identical to the naturally occurring cortisol, a hormone produced by the adrenal gland that helps regulate metabolism and helps your body respond to stress. Hydrocortisone has anti-inflammatory effects and is used to treat various inflammatory conditions such as allergies, skin disorders, and autoimmune diseases. It works by suppressing the immune system's response to reduce swelling, redness, itching, and other symptoms caused by inflammation.

Hydrocortisone is available in different forms, including oral tablets, topical creams, lotions, gels, and ointments, as well as injectable solutions. The specific use and dosage depend on the condition being treated and the individual patient's medical history and current health status.

As with any medication, hydrocortisone can have side effects, especially when used in high doses or for extended periods. Common side effects include increased appetite, weight gain, mood changes, insomnia, and skin thinning. Long-term use of hydrocortisone may also increase the risk of developing osteoporosis, diabetes, cataracts, and other health problems. Therefore, it is essential to follow your healthcare provider's instructions carefully when using this medication.

Hydroxyprogesterone is a synthetic form of the natural hormone progesterone, which is produced by the body during pregnancy to support the growth and development of the fetus. Hydroxyprogesterone is used in medical treatments to help prevent preterm birth in certain high-risk pregnancies.

There are several different forms of hydroxyprogesterone that have been developed for use as medications, including:

1. Hydroxyprogesterone caproate (HPC): This is a synthetic form of progesterone that is given as an injection once a week to help prevent preterm birth in women who have previously given birth prematurely. It works by helping to thicken the lining of the uterus and prevent contractions.
2. 17-Hydroxyprogesterone: This is a natural hormone that is produced by the body during pregnancy, but it can also be synthesized in a laboratory for use as a medication. It has been studied for its potential to help prevent preterm birth, although it is not currently approved for this use by the U.S. Food and Drug Administration (FDA).
3. 21-Hydroxyprogesterone: This is another natural hormone that is produced by the body during pregnancy, but it can also be synthesized in a laboratory for use as a medication. It has been studied for its potential to help prevent preterm birth and for its ability to reduce the risk of certain complications in women with a history of premature birth.

It's important to note that hydroxyprogesterone should only be used under the supervision of a healthcare provider, as it can have side effects and may not be appropriate for all women. If you are pregnant or planning to become pregnant and have concerns about preterm birth, it's important to discuss your options with your healthcare provider.

Steroid 16-alpha-Hydroxylase is an enzyme that catalyzes the reaction adding a hydroxyl group to the sixteen (16) alpha position of steroid molecules. This enzyme is involved in the metabolic pathways of various steroids, including cortisol, aldosterone, and some sex hormones.

The gene that encodes this enzyme is CYP3A4, which is part of the cytochrome P450 family. The 16-alpha-hydroxylase activity of this enzyme has been implicated in several physiological and pathophysiological processes, such as steroid hormone biosynthesis, drug metabolism, and cancer progression.

It's worth noting that the activity of this enzyme can vary among individuals, which may contribute to differences in steroid hormone levels and susceptibility to certain diseases.

The Cytochrome P-450 (CYP450) enzyme system is a group of enzymes found primarily in the liver, but also in other organs such as the intestines, lungs, and skin. These enzymes play a crucial role in the metabolism and biotransformation of various substances, including drugs, environmental toxins, and endogenous compounds like hormones and fatty acids.

The name "Cytochrome P-450" refers to the unique property of these enzymes to bind to carbon monoxide (CO) and form a complex that absorbs light at a wavelength of 450 nm, which can be detected spectrophotometrically.

The CYP450 enzyme system is involved in Phase I metabolism of xenobiotics, where it catalyzes oxidation reactions such as hydroxylation, dealkylation, and epoxidation. These reactions introduce functional groups into the substrate molecule, which can then undergo further modifications by other enzymes during Phase II metabolism.

There are several families and subfamilies of CYP450 enzymes, each with distinct substrate specificities and functions. Some of the most important CYP450 enzymes include:

1. CYP3A4: This is the most abundant CYP450 enzyme in the human liver and is involved in the metabolism of approximately 50% of all drugs. It also metabolizes various endogenous compounds like steroids, bile acids, and vitamin D.
2. CYP2D6: This enzyme is responsible for the metabolism of many psychotropic drugs, including antidepressants, antipsychotics, and beta-blockers. It also metabolizes some endogenous compounds like dopamine and serotonin.
3. CYP2C9: This enzyme plays a significant role in the metabolism of warfarin, phenytoin, and nonsteroidal anti-inflammatory drugs (NSAIDs).
4. CYP2C19: This enzyme is involved in the metabolism of proton pump inhibitors, antidepressants, and clopidogrel.
5. CYP2E1: This enzyme metabolizes various xenobiotics like alcohol, acetaminophen, and carbon tetrachloride, as well as some endogenous compounds like fatty acids and prostaglandins.

Genetic polymorphisms in CYP450 enzymes can significantly affect drug metabolism and response, leading to interindividual variability in drug efficacy and toxicity. Understanding the role of CYP450 enzymes in drug metabolism is crucial for optimizing pharmacotherapy and minimizing adverse effects.

Steroid hydroxylases are enzymes that catalyze the addition of a hydroxyl group (-OH) to a steroid molecule. These enzymes are located in the endoplasmic reticulum and play a crucial role in the biosynthesis of various steroid hormones, such as cortisol, aldosterone, and sex hormones. The hydroxylation reaction catalyzed by these enzymes increases the polarity and solubility of steroids, allowing them to be further metabolized and excreted from the body.

The most well-known steroid hydroxylases are part of the cytochrome P450 family, specifically CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, and CYP21A2. Each enzyme has a specific function in steroid biosynthesis, such as converting cholesterol to pregnenolone (CYP11A1), hydroxylating the 11-beta position of steroids (CYP11B1 and CYP11B2), or performing multiple hydroxylation reactions in the synthesis of sex hormones (CYP17A1, CYP19A1, and CYP21A2).

Defects in these enzymes can lead to various genetic disorders, such as congenital adrenal hyperplasia, which is characterized by impaired steroid hormone biosynthesis.

Sprague-Dawley rats are a strain of albino laboratory rats that are widely used in scientific research. They were first developed by researchers H.H. Sprague and R.C. Dawley in the early 20th century, and have since become one of the most commonly used rat strains in biomedical research due to their relatively large size, ease of handling, and consistent genetic background.

Sprague-Dawley rats are outbred, which means that they are genetically diverse and do not suffer from the same limitations as inbred strains, which can have reduced fertility and increased susceptibility to certain diseases. They are also characterized by their docile nature and low levels of aggression, making them easier to handle and study than some other rat strains.

These rats are used in a wide variety of research areas, including toxicology, pharmacology, nutrition, cancer, and behavioral studies. Because they are genetically diverse, Sprague-Dawley rats can be used to model a range of human diseases and conditions, making them an important tool in the development of new drugs and therapies.

I'm sorry for any confusion, but "Azasteroids" is not a medical term or concept. The term "azasteroids" is used in the field of chemistry to refer to a class of compounds that are structurally similar to steroids but have an aziridine ring (a three-membered ring containing two carbon atoms and one nitrogen atom) instead of the usual four-membered ring in the steroid structure.

These compounds may have potential applications in various fields, including medicinal chemistry, but they are not a medical concept or diagnosis. If you have any questions related to medical terminology or health concerns, I would be happy to help you with those!

Cryptorchidism is a medical condition in which one or both of a male infant's testicles fail to descend from the abdomen into the scrotum before birth or within the first year of life. Normally, the testicles descend from the abdomen into the scrotum during fetal development in the second trimester. If the testicles do not descend on their own, medical intervention may be necessary to correct the condition.

Cryptorchidism is a common birth defect, affecting about 3-5% of full-term and 30% of preterm male infants. In most cases, the testicle will descend on its own within the first six months of life. If it does not, treatment may be necessary to prevent complications such as infertility, testicular cancer, and inguinal hernia.

Treatment for cryptorchidism typically involves surgery to bring the testicle down into the scrotum. This procedure is called orchiopexy and is usually performed before the age of 2. In some cases, hormonal therapy may be used as an alternative to surgery. However, this approach has limited success and is generally only recommended in certain situations.

Overall, cryptorchidism is a treatable condition that can help prevent future health problems if addressed early on. Regular check-ups with a pediatrician or healthcare provider can help ensure timely diagnosis and treatment of this condition.

"Sex differentiation" is a term used in the field of medicine, specifically in reproductive endocrinology and genetics. It refers to the biological development of sexual characteristics that distinguish males from females. This process is regulated by hormones and genetic factors.

There are two main stages of sex differentiation: genetic sex determination and gonadal sex differentiation. Genetic sex determination occurs at fertilization, where the combination of X and Y chromosomes determines the sex of the individual (typically, XX = female and XY = male). Gonadal sex differentiation then takes place during fetal development, where the genetic sex signals the development of either ovaries or testes.

Once the gonads are formed, they produce hormones that drive further sexual differentiation, leading to the development of internal reproductive structures (such as the uterus and fallopian tubes in females, and the vas deferens and seminal vesicles in males) and external genitalia.

It's important to note that while sex differentiation is typically categorized as male or female, there are individuals who may have variations in their sexual development, leading to intersex conditions. These variations can occur at any stage of the sex differentiation process and can result in a range of physical characteristics that do not fit neatly into male or female categories.

Androgen Insensitivity Syndrome (AIS) is a genetic condition that occurs in individuals who are genetically male (have one X and one Y chromosome) but are resistant to androgens, which are hormones that play a role in male sexual development. This resistance is caused by changes (mutations) in the gene for the androgen receptor.

There are three main types of AIS: complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS), and mild androgen insensitivity syndrome (MAIS).

In CAIS, individuals are completely resistant to androgens, which results in the development of female external genitalia at birth. Despite having testes, these individuals do not have a functioning male reproductive system and typically have a female gender identity. They may be diagnosed during adolescence when they do not begin to menstruate or experience other signs of puberty.

In PAIS and MAIS, the degree of androgen insensitivity varies, resulting in a range of physical characteristics that can include both male and female features. These individuals may have ambiguous genitalia at birth, and their gender identity may not align with their genetic sex.

It's important to note that people with AIS are typically healthy and do not have an increased risk of medical conditions beyond those related to their hormonal differences. However, they may face challenges related to their gender identity, sexual development, and fertility. It is recommended that individuals with AIS receive comprehensive medical care and support from a team of healthcare professionals who specialize in this condition.

Transsexualism is not considered a medical condition in itself, but rather a symptom or a part of a larger gender dysphoria diagnosis. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), published by the American Psychiatric Association, gender dysphoria refers to the distress that may accompany the incongruence between one's experienced or expressed gender and one's assigned gender.

Transsexualism is an outdated term that was previously used to describe individuals who strongly identify with a gender different from the one they were assigned at birth and wish to permanently transition to their identified gender through medical and social means, including hormone therapy and gender confirmation surgery. The current preferred terminology is to use the term "transgender" as an umbrella term that includes all people whose gender identity differs from the sex they were assigned at birth.

It's important to note that being transgender is not a mental illness, but rather a part of human diversity. The distress that some transgender individuals experience is primarily due to societal stigma and discrimination, rather than their gender identity itself.

An ovary is a part of the female reproductive system in which ova or eggs are produced through the process of oogenesis. They are a pair of solid, almond-shaped structures located one on each side of the uterus within the pelvic cavity. Each ovary measures about 3 to 5 centimeters in length and weighs around 14 grams.

The ovaries have two main functions: endocrine (hormonal) function and reproductive function. They produce and release eggs (ovulation) responsible for potential fertilization and development of an embryo/fetus during pregnancy. Additionally, they are essential in the production of female sex hormones, primarily estrogen and progesterone, which regulate menstrual cycles, sexual development, and reproduction.

During each menstrual cycle, a mature egg is released from one of the ovaries into the fallopian tube, where it may be fertilized by sperm. If not fertilized, the egg, along with the uterine lining, will be shed, leading to menstruation.

The scrotum is a part of the external male genitalia. It's a sac-like structure made up of several layers of skin and smooth muscle, which hangs down behind and beneath the penis. The primary function of the scrotum is to maintain the testicles at a temperature slightly lower than the core body temperature, which is optimal for sperm production.

The scrotum contains two compartments, each one housing a testicle. It's located in the pubic region and is usually visible externally. The skin of the scrotum is thin and wrinkled, which allows it to expand and contract depending on the temperature, accommodating the shrinking or swelling of the testicles.

Please note that while I strive to provide accurate information, this definition is intended to be a general overview and should not replace professional medical advice.

Body weight is the measure of the force exerted on a scale or balance by an object's mass, most commonly expressed in units such as pounds (lb) or kilograms (kg). In the context of medical definitions, body weight typically refers to an individual's total weight, which includes their skeletal muscle, fat, organs, and bodily fluids.

Healthcare professionals often use body weight as a basic indicator of overall health status, as it can provide insights into various aspects of a person's health, such as nutritional status, metabolic function, and risk factors for certain diseases. For example, being significantly underweight or overweight can increase the risk of developing conditions like malnutrition, diabetes, heart disease, and certain types of cancer.

It is important to note that body weight alone may not provide a complete picture of an individual's health, as it does not account for factors such as muscle mass, bone density, or body composition. Therefore, healthcare professionals often use additional measures, such as body mass index (BMI), waist circumference, and blood tests, to assess overall health status more comprehensively.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Andropause is a term that is sometimes used to describe the gradual decrease in hormone production that occurs in middle-aged men. The term is not widely accepted or used in the medical community, and it is not officially recognized as a medical condition.

The more commonly used medical term for this phenomenon is "testosterone deficiency" or "hypogonadism," which refers to a decrease in the production of the hormone testosterone by the testes. This can lead to various symptoms such as decreased sex drive, fatigue, mood changes, and difficulty with concentration and memory.

It's important to note that while some men may experience these symptoms as they age, not all men will develop a testosterone deficiency. Additionally, other factors such as chronic medical conditions or medications can also contribute to these symptoms. A healthcare provider can evaluate symptoms and perform tests to determine if a testosterone deficiency is present and recommend appropriate treatment options.

Doping in sports is the use of prohibited substances or methods to improve athletic performance. The World Anti-Doping Agency (WADA) defines doping as "the occurrence of one or more of the following anti-doping rule violations":

1. Presence of a prohibited substance in an athlete's sample
2. Use or attempted use of a prohibited substance or method
3. Evading, refusing, or failing to submit to sample collection
4. Whereabouts failures (three missed tests or filing failures within a 12-month period)
5. Tampering or attempted tampering with any part of the doping control process
6. Possession, trafficking, or administration of a prohibited substance or method
7. Complicity in an anti-doping rule violation
8. Prohibited association with a person who has been serving a period of ineligibility for an anti-doping rule violation

Doping is considered unethical and harmful to the integrity of sports, as it provides an unfair advantage to those who engage in it. It can also have serious health consequences for athletes. Various international and national organizations, including WADA and the United States Anti-Doping Agency (USADA), work to prevent doping in sports through education, testing, and enforcement of anti-doping rules.

Copulation is the act of sexual reproduction in animals, achieved through the process of mating and engaging in sexual intercourse. It involves the insertion of the male's reproductive organ (the penis) into the female's reproductive organ (vagina), followed by the ejaculation of semen, which contains sperm. The sperm then travels up through the cervix and into the uterus, where they may fertilize an egg or ovum that has been released from one of the ovaries.

In a broader sense, copulation can also refer to the act of reproduction in other organisms, such as plants, fungi, and protists, which may involve different processes such as pollination, fusion of gametes, or vegetative reproduction.

Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It can have physical and psychological causes, such as underlying health conditions like diabetes, heart disease, obesity, and mental health issues like stress, anxiety, and depression. ED can also be a side effect of certain medications. Treatment options include lifestyle changes, medication, counseling, and in some cases, surgery.

A dose-response relationship in the context of drugs refers to the changes in the effects or symptoms that occur as the dose of a drug is increased or decreased. Generally, as the dose of a drug is increased, the severity or intensity of its effects also increases. Conversely, as the dose is decreased, the effects of the drug become less severe or may disappear altogether.

The dose-response relationship is an important concept in pharmacology and toxicology because it helps to establish the safe and effective dosage range for a drug. By understanding how changes in the dose of a drug affect its therapeutic and adverse effects, healthcare providers can optimize treatment plans for their patients while minimizing the risk of harm.

The dose-response relationship is typically depicted as a curve that shows the relationship between the dose of a drug and its effect. The shape of the curve may vary depending on the drug and the specific effect being measured. Some drugs may have a steep dose-response curve, meaning that small changes in the dose can result in large differences in the effect. Other drugs may have a more gradual dose-response curve, where larger changes in the dose are needed to produce significant effects.

In addition to helping establish safe and effective dosages, the dose-response relationship is also used to evaluate the potential therapeutic benefits and risks of new drugs during clinical trials. By systematically testing different doses of a drug in controlled studies, researchers can identify the optimal dosage range for the drug and assess its safety and efficacy.

Diethylstilbestrol (DES) is a synthetic form of the hormone estrogen that was prescribed to pregnant women from the 1940s until the early 1970s to prevent miscarriage, premature labor, and other complications of pregnancy. However, it was later discovered that DES could cause serious health problems in both the mothers who took it and their offspring.

DES is a non-selective estrogen agonist, meaning that it binds to and activates both estrogen receptors (ERα and ERβ) in the body. It has a higher binding affinity for ERα than for ERβ, which can lead to disruptions in normal hormonal signaling pathways.

In addition to its use as a pregnancy aid, DES has also been used in the treatment of prostate cancer, breast cancer, and other conditions associated with hormonal imbalances. However, due to its potential health risks, including an increased risk of certain cancers, DES is no longer widely used in clinical practice.

Some of the known health effects of DES exposure include:

* In women who were exposed to DES in utero (i.e., their mothers took DES during pregnancy):
+ A rare form of vaginal or cervical cancer called clear cell adenocarcinoma
+ Abnormalities of the reproductive system, such as structural changes in the cervix and vagina, and an increased risk of infertility, ectopic pregnancy, and preterm delivery
+ An increased risk of breast cancer later in life
* In men who were exposed to DES in utero:
+ Undescended testicles
+ Abnormalities of the penis and scrotum
+ A higher risk of testicular cancer
* In both men and women who were exposed to DES in utero or who took DES themselves:
+ An increased risk of certain types of breast cancer
+ A possible increased risk of cardiovascular disease, including high blood pressure and stroke.

It is important for individuals who have been exposed to DES to inform their healthcare providers of this fact, as it may have implications for their medical care and monitoring.

"Inbred strains of rats" are genetically identical rodents that have been produced through many generations of brother-sister mating. This results in a high degree of homozygosity, where the genes at any particular locus in the genome are identical in all members of the strain.

Inbred strains of rats are widely used in biomedical research because they provide a consistent and reproducible genetic background for studying various biological phenomena, including the effects of drugs, environmental factors, and genetic mutations on health and disease. Additionally, inbred strains can be used to create genetically modified models of human diseases by introducing specific mutations into their genomes.

Some commonly used inbred strains of rats include the Wistar Kyoto (WKY), Sprague-Dawley (SD), and Fischer 344 (F344) rat strains. Each strain has its own unique genetic characteristics, making them suitable for different types of research.

Prostatic neoplasms refer to abnormal growths in the prostate gland, which can be benign or malignant. The term "neoplasm" simply means new or abnormal tissue growth. When it comes to the prostate, neoplasms are often referred to as tumors.

Benign prostatic neoplasms, such as prostate adenomas, are non-cancerous overgrowths of prostate tissue. They usually grow slowly and do not spread to other parts of the body. While they can cause uncomfortable symptoms like difficulty urinating, they are generally not life-threatening.

Malignant prostatic neoplasms, on the other hand, are cancerous growths. The most common type of prostate cancer is adenocarcinoma, which arises from the glandular cells in the prostate. Prostate cancer often grows slowly and may not cause any symptoms for many years. However, some types of prostate cancer can be aggressive and spread quickly to other parts of the body, such as the bones or lymph nodes.

It's important to note that while prostate neoplasms can be concerning, early detection and treatment can significantly improve outcomes for many men. Regular check-ups with a healthcare provider are key to monitoring prostate health and catching any potential issues early on.

Klinefelter Syndrome: A genetic disorder in males, caused by the presence of one or more extra X chromosomes, typically resulting in XXY karyotype. It is characterized by small testes, infertility, gynecomastia (breast enlargement), tall stature, and often mild to moderate intellectual disability. The symptoms can vary greatly among individuals with Klinefelter Syndrome. Some men may not experience any significant health problems and may never be diagnosed, while others may have serious medical or developmental issues that require treatment. It is one of the most common chromosomal disorders, affecting about 1 in every 500-1,000 newborn males.

Puberty is the period of sexual maturation, generally occurring between the ages of 10 and 16 in females and between 12 and 18 in males. It is characterized by a series of events including rapid growth, development of secondary sexual characteristics, and the acquisition of reproductive capabilities. Puberty is initiated by the activation of the hypothalamic-pituitary-gonadal axis, leading to the secretion of hormones such as estrogen and testosterone that drive the physical changes associated with this stage of development.

In females, puberty typically begins with the onset of breast development (thelarche) and the appearance of pubic hair (pubarche), followed by the start of menstruation (menarche). In males, puberty usually starts with an increase in testicular size and the growth of pubic hair, followed by the deepening of the voice, growth of facial hair, and the development of muscle mass.

It's important to note that the onset and progression of puberty can vary widely among individuals, and may be influenced by genetic, environmental, and lifestyle factors.

Microsomes, liver refers to a subcellular fraction of liver cells (hepatocytes) that are obtained during tissue homogenization and subsequent centrifugation. These microsomal fractions are rich in membranous structures known as the endoplasmic reticulum (ER), particularly the rough ER. They are involved in various important cellular processes, most notably the metabolism of xenobiotics (foreign substances) including drugs, toxins, and carcinogens.

The liver microsomes contain a variety of enzymes, such as cytochrome P450 monooxygenases, that are crucial for phase I drug metabolism. These enzymes help in the oxidation, reduction, or hydrolysis of xenobiotics, making them more water-soluble and facilitating their excretion from the body. Additionally, liver microsomes also host other enzymes involved in phase II conjugation reactions, where the metabolites from phase I are further modified by adding polar molecules like glucuronic acid, sulfate, or acetyl groups.

In summary, liver microsomes are a subcellular fraction of liver cells that play a significant role in the metabolism and detoxification of xenobiotics, contributing to the overall protection and maintenance of cellular homeostasis within the body.

Cytochrome P-450 CYP3A is a subfamily of the cytochrome P-450 enzyme superfamily, which are primarily involved in drug metabolism in the human body. These enzymes are found predominantly in the liver, but also in other tissues such as the small intestine, kidneys, and brain.

CYP3A enzymes are responsible for metabolizing a wide variety of drugs, including many statins, benzodiazepines, antidepressants, and opioids. They can also metabolize endogenous compounds such as steroids and bile acids. The activity of CYP3A enzymes can be influenced by various factors, including genetic polymorphisms, age, sex, pregnancy, and the presence of other drugs or diseases.

The name "cytochrome P-450" refers to the fact that these enzymes contain a heme group that absorbs light at a wavelength of 450 nanometers when it is complexed with carbon monoxide. The term "CYP3A" denotes the specific subfamily of cytochrome P-450 enzymes that share a high degree of sequence similarity and function.

The Cholesterol Side-Chain Cleavage Enzyme, also known as Steroidogenic Acute Regulatory (StAR) protein or P450scc, is a complex enzymatic system that plays a crucial role in the production of steroid hormones. It is located in the inner mitochondrial membrane of steroid-producing cells, such as those found in the adrenal glands, gonads, and placenta.

The Cholesterol Side-Chain Cleavage Enzyme is responsible for converting cholesterol into pregnenolone, which is the first step in the biosynthesis of all steroid hormones, including cortisol, aldosterone, sex hormones, and vitamin D. This enzymatic complex consists of two components: a flavoprotein called NADPH-cytochrome P450 oxidoreductase, which provides electrons for the reaction, and a cytochrome P450 protein called CYP11A1, which catalyzes the actual cleavage of the cholesterol side chain.

Defects in the Cholesterol Side-Chain Cleavage Enzyme can lead to various genetic disorders, such as congenital lipoid adrenal hyperplasia (CLAH), a rare autosomal recessive disorder characterized by impaired steroidogenesis and accumulation of cholesteryl esters in the adrenal glands and gonads.

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

Ovariectomy is a surgical procedure in which one or both ovaries are removed. It is also known as "ovary removal" or "oophorectomy." This procedure is often performed as a treatment for various medical conditions, including ovarian cancer, endometriosis, uterine fibroids, and pelvic pain. Ovariectomy can also be part of a larger surgical procedure called an hysterectomy, in which the uterus is also removed.

In some cases, an ovariectomy may be performed as a preventative measure for individuals at high risk of developing ovarian cancer. This is known as a prophylactic ovariectomy. After an ovariectomy, a person will no longer have menstrual periods and will be unable to become pregnant naturally. Hormone replacement therapy may be recommended in some cases to help manage symptoms associated with the loss of hormones produced by the ovaries.

I'm sorry for any confusion, but "territoriality" is not a term that has a specific medical definition. It is a concept that is more commonly used in the fields of psychology, sociology, and animal behavior to refer to the tendency of an individual or group to defend a particular territory from intrusion by others.

In a medical context, the term "territory" may be used more broadly to refer to a specific area or region of the body that is associated with a particular medical condition or specialty. For example, a neurologist might refer to the "territory" of the brain that is affected by a stroke or other type of brain injury.

If you have any further questions about medical terminology or concepts, please don't hesitate to ask!

Hypophysectomy is a surgical procedure that involves the removal or partial removal of the pituitary gland, also known as the hypophysis. The pituitary gland is a small endocrine gland located at the base of the brain, just above the nasal cavity, and is responsible for producing and secreting several important hormones that regulate various bodily functions.

Hypophysectomy may be performed for therapeutic or diagnostic purposes. In some cases, it may be used to treat pituitary tumors or other conditions that affect the function of the pituitary gland. It may also be performed as a research procedure in animal models to study the effects of pituitary hormone deficiency on various physiological processes.

The surgical approach for hypophysectomy may vary depending on the specific indication and the patient's individual anatomy. In general, however, the procedure involves making an incision in the skull and exposing the pituitary gland through a small opening in the bone. The gland is then carefully dissected and removed or partially removed as necessary.

Potential complications of hypophysectomy include damage to surrounding structures such as the optic nerves, which can lead to vision loss, and cerebrospinal fluid leaks. Additionally, removal of the pituitary gland can result in hormonal imbalances that may require long-term management with hormone replacement therapy.

"Social dominance" is not a term that has a specific medical definition. However, it is a concept that is often used in the social sciences, including sociology, psychology, and anthropology. It refers to the degree of control, influence, or power that an individual or group has over others within a particular social context or hierarchy.

In some cases, social dominance may be associated with certain medical conditions or situations. For example, individuals with antisocial personality disorder or other psychiatric disorders may exhibit dominant behaviors as part of their symptoms. Similarly, social dominance can be a factor in the development and maintenance of certain types of relationships, such as those seen in abusive or coercive relationships.

However, it's important to note that social dominance is not a medical diagnosis or condition in and of itself. Rather, it is a social phenomenon that can intersect with various medical and psychological issues.

Aryl hydrocarbon hydroxylases (AHH) are a group of enzymes that play a crucial role in the metabolism of various aromatic and heterocyclic compounds, including potentially harmful substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. These enzymes are primarily located in the endoplasmic reticulum of cells, particularly in the liver, but can also be found in other tissues.

The AHH enzymes catalyze the addition of a hydroxyl group (-OH) to the aromatic ring structure of these compounds, which is the first step in their biotransformation and eventual elimination from the body. This process can sometimes lead to the formation of metabolites that are more reactive and potentially toxic than the original compound. Therefore, the overall impact of AHH enzymes on human health is complex and depends on various factors, including the specific compounds being metabolized and individual genetic differences in enzyme activity.

Aromatase inhibitors (AIs) are a class of drugs that are primarily used in the treatment of hormone-sensitive breast cancer in postmenopausal women. They work by inhibiting the enzyme aromatase, which is responsible for converting androgens into estrogens. By blocking this conversion, AIs decrease the amount of estrogen in the body, thereby depriving hormone-sensitive breast cancer cells of the estrogen they need to grow and multiply.

There are three main types of aromatase inhibitors:

1. Letrozole (Femara) - a non-steroidal AI that is taken orally once a day.
2. Anastrozole (Arimidex) - another non-steroidal AI that is also taken orally once a day.
3. Exemestane (Aromasin) - a steroidal AI that is taken orally once a day.

In addition to their use in breast cancer treatment, AIs are also sometimes used off-label for the treatment of estrogen-dependent conditions such as endometriosis and uterine fibroids. However, it's important to note that the use of aromatase inhibitors can have significant side effects, including hot flashes, joint pain, and bone loss, so they should only be used under the close supervision of a healthcare provider.

The preoptic area (POA) is a region within the anterior hypothalamus of the brain. It is named for its location near the optic chiasm, where the optic nerves cross. The preoptic area is involved in various functions, including body temperature regulation, sexual behavior, and sleep-wake regulation.

The preoptic area contains several groups of neurons that are sensitive to changes in temperature and are responsible for generating heat through shivering or non-shivering thermogenesis. It also contains neurons that release inhibitory neurotransmitters such as GABA and galanin, which help regulate arousal and sleep.

Additionally, the preoptic area has been implicated in the regulation of sexual behavior, particularly in males. Certain populations of neurons within the preoptic area are involved in the expression of male sexual behavior, such as mounting and intromission.

Overall, the preoptic area is a critical region for the regulation of various physiological and behavioral functions, making it an important area of study in neuroscience research.

Ketoconazole is an antifungal medication that is primarily used to treat various fungal infections, including those caused by dermatophytes, Candida, and pityrosporum. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes, which leads to increased permeability and ultimately results in fungal cell death.

Ketoconazole is available as an oral tablet for systemic use and as a topical cream or shampoo for localized applications. The oral formulation is used to treat severe or invasive fungal infections, while the topical preparations are primarily indicated for skin and scalp infections, such as athlete's foot, ringworm, jock itch, candidiasis, and seborrheic dermatitis.

Common side effects of oral ketoconazole include nausea, vomiting, headache, and altered liver function tests. Rare but serious adverse reactions may include hepatotoxicity, adrenal insufficiency, and interactions with other medications that can affect the metabolism and elimination of drugs. Topical ketoconazole is generally well-tolerated, with local irritation being the most common side effect.

It's important to note that due to its potential for serious liver toxicity and drug-drug interactions, oral ketoconazole has been largely replaced by other antifungal agents, such as fluconazole and itraconazole, which have more favorable safety profiles. Topical ketoconazole remains a valuable option for treating localized fungal infections due to its effectiveness and lower risk of systemic side effects.

Luteinizing Hormone (LH) receptors are specialized protein structures found on the surface of certain cells in the body. They play a crucial role in the endocrine system by binding to specific hormones, such as Luteinizing Hormone, and triggering a series of intracellular events that ultimately lead to changes in cell function.

In particular, LH receptors are found on the cells of the ovaries and testes. In females, when LH binds to its receptor in the ovary, it stimulates ovulation and the development of the corpus luteum, which produces progesterone. In males, LH (also known as Interstitial Cell-Stimulating Hormone in this context) binding to its receptor on testicular Leydig cells triggers the production of testosterone.

Therefore, LH receptors are essential for reproductive processes and the maintenance of secondary sexual characteristics.

Sexual development is a multidimensional process that includes physical, cognitive, emotional, and social aspects. It refers to the changes and growth that occur in an individual from infancy to adulthood related to sexuality, reproduction, and gender identity. This process involves the maturation of primary and secondary sex characteristics, the development of sexual attraction and desire, and the acquisition of knowledge about sexual health and relationships.

Physical aspects of sexual development include the maturation of reproductive organs, hormonal changes, and the development of secondary sexual characteristics such as breast development in females and facial hair growth in males. Cognitive aspects involve the development of sexual knowledge, attitudes, and values. Emotional aspects refer to the emergence of sexual feelings, desires, and fantasies, as well as the ability to form intimate relationships. Social aspects include the development of gender roles and identities, communication skills related to sexuality, and the ability to navigate social norms and expectations around sexual behavior.

Sexual development is a complex and ongoing process that is influenced by various factors such as genetics, hormones, environment, culture, and personal experiences. It is important to note that sexual development varies widely among individuals, and there is no one "normal" or "correct" way for it to unfold.

Semen is a complex, whitish fluid that is released from the male reproductive system during ejaculation. It is produced by several glands, including the seminal vesicles, prostate gland, and bulbourethral glands. Semen contains several components, including sperm (the male reproductive cells), as well as various proteins, enzymes, vitamins, and minerals. Its primary function is to transport sperm through the female reproductive tract during sexual intercourse, providing nutrients and aiding in the protection of the sperm as they travel toward the egg for fertilization.

Pregnenolone is defined as a steroid hormone produced in the body from cholesterol. It's often referred to as the "mother hormone" since many other hormones, including cortisol, aldosterone, progesterone, testosterone, and estrogen, are synthesized from it.

Pregnenolone is primarily produced in the adrenal glands but can also be produced in smaller amounts in the brain, skin, and sex organs (ovaries and testes). It plays a crucial role in various physiological processes such as maintaining membrane fluidity, acting as an antioxidant, and contributing to cognitive function.

However, it's important to note that while pregnenolone is a hormone, over-the-counter supplements containing this compound are not approved by the FDA for any medical use or condition. As always, consult with a healthcare provider before starting any new supplement regimen.

Androgen-binding protein (ABP) is a protein that binds specifically to androgens, which are hormones such as testosterone that play a role in male sexual development and masculine characteristics. ABP is produced in the Sertoli cells of the testes and helps to regulate the levels of androgens within the testes by storing them and slowly releasing them over time. This is important for maintaining normal sperm production and male reproductive function.

ABP is also found in other tissues, including the prostate gland, where it may play a role in regulating the growth and development of this tissue. Abnormal levels of ABP have been associated with certain medical conditions, such as prostate cancer and infertility.

Dibutyl phthalate (DBP) is a synthetic chemical compound that belongs to a class of chemicals called phthalates. It is a colorless, oily liquid with a mild odor and is widely used as a plasticizer to make plastics more flexible and durable. DBP is commonly added to polyvinyl chloride (PVC) products such as vinyl flooring, wall coverings, shower curtains, and consumer products like cosmetics, personal care products, and cleaning solutions.

In medical terms, DBP has been identified as a reproductive toxicant and endocrine disruptor, which means it can interfere with the body's hormonal system and potentially affect reproductive health. Studies have shown that exposure to DBP during pregnancy may be associated with adverse outcomes such as reduced fetal growth, abnormalities in male reproductive development, and behavioral problems in children.

Therefore, it is important to limit exposure to DBP and other phthalates, especially for pregnant women and young children. Some steps you can take to reduce your exposure include avoiding plastic containers with the recycling codes 3 or 7 (which may contain phthalates), choosing personal care products that are labeled "phthalate-free," and using natural cleaning products whenever possible.

"Prenatal exposure delayed effects" refer to the adverse health outcomes or symptoms that become apparent in an individual during their development or later in life, which are caused by exposure to certain environmental factors or substances while they were still in the womb. These effects may not be immediately observable at birth and can take weeks, months, years, or even decades to manifest. They can result from maternal exposure to various agents such as infectious diseases, medications, illicit drugs, tobacco smoke, alcohol, or environmental pollutants during pregnancy. The delayed effects can impact multiple organ systems and may include physical, cognitive, behavioral, and developmental abnormalities. It is important to note that the risk and severity of these effects can depend on several factors, including the timing, duration, and intensity of the exposure, as well as the individual's genetic susceptibility.

Antlers are defined in medical terminology as the continuously growing, branched bony appendages that arise from the skull of members of the Cervidae family, which includes deer, elk, and moose. Antler growth and development are unique to this group of animals and are under the control of hormones and genetics. They serve as a means of defense, dominance display, and sexual selection.

During the growth phase, antlers are covered with highly vascular skin called "velvet," which provides nutrients for the rapid growth of bone. Once growth is complete, typically in late summer, the velvet is shed, revealing the hard, bony antler structure. The antlers are then used by males during the mating season as a tool to compete for females and establish dominance hierarchies.

In some species, only males grow antlers, while in others, both males and females develop them. After the mating season, the animals shed their antlers, which regenerate the following year. The study of antlers is known as palynology.

"Intramuscular injections" refer to a medical procedure where a medication or vaccine is administered directly into the muscle tissue. This is typically done using a hypodermic needle and syringe, and the injection is usually given into one of the large muscles in the body, such as the deltoid (shoulder), vastus lateralis (thigh), or ventrogluteal (buttock) muscles.

Intramuscular injections are used for a variety of reasons, including to deliver medications that need to be absorbed slowly over time, to bypass stomach acid and improve absorption, or to ensure that the medication reaches the bloodstream quickly and directly. Common examples of medications delivered via intramuscular injection include certain vaccines, antibiotics, and pain relievers.

It is important to follow proper technique when administering intramuscular injections to minimize pain and reduce the risk of complications such as infection or injury to surrounding tissues. Proper site selection, needle length and gauge, and injection technique are all critical factors in ensuring a safe and effective intramuscular injection.

The penis is a part of the male reproductive and urinary systems. It has three parts: the root, the body, and the glans. The root attaches to the pelvic bone and the body makes up the majority of the free-hanging portion. The glans is the cone-shaped end that protects the urethra, the tube inside the penis that carries urine from the bladder and semen from the testicles.

The penis has a dual function - it acts as a conduit for both urine and semen. During sexual arousal, the penis becomes erect when blood fills two chambers inside its shaft. This process is facilitated by the relaxation of the smooth muscles in the arterial walls and the trappping of blood in the corpora cavernosa. The stiffness of the penis enables sexual intercourse. After ejaculation, or when the sexual arousal passes, the muscles contract and the blood flows out of the penis back into the body, causing it to become flaccid again.

The foreskin, a layer of skin that covers the glans, is sometimes removed in a procedure called circumcision. Circumcision is often performed for religious or cultural reasons, or as a matter of family custom. In some countries, it's also done for medical reasons, such as to treat conditions like phimosis (an inability to retract the foreskin) or balanitis (inflammation of the glans).

It's important to note that any changes in appearance, size, or function of the penis should be evaluated by a healthcare professional, as they could indicate an underlying medical condition.

Gonadal hormones, also known as sex hormones, are steroid hormones that are primarily produced by the gonads (ovaries in females and testes in males). They play crucial roles in the development and regulation of sexual characteristics and reproductive functions. The three main types of gonadal hormones are:

1. Estrogens - predominantly produced by ovaries, they are essential for female sexual development and reproduction. The most common estrogen is estradiol, which supports the growth and maintenance of secondary sexual characteristics in women, such as breast development and wider hips. Estrogens also play a role in regulating the menstrual cycle and maintaining bone health.

2. Progesterone - primarily produced by ovaries during the menstrual cycle and pregnancy, progesterone prepares the uterus for implantation of a fertilized egg and supports the growth and development of the fetus during pregnancy. It also plays a role in regulating the menstrual cycle.

3. Androgens - produced by both ovaries and testes, but primarily by testes in males. The most common androgen is testosterone, which is essential for male sexual development and reproduction. Testosterone supports the growth and maintenance of secondary sexual characteristics in men, such as facial hair, a deeper voice, and increased muscle mass. It also plays a role in regulating sex drive (libido) and bone health in both males and females.

In summary, gonadal hormones are steroid hormones produced by the gonads that play essential roles in sexual development, reproduction, and maintaining secondary sexual characteristics.

Androstenediol is an endogenous steroid hormone that is produced in the body from dehydroepiandrosterone (DHEA) and converted into testosterone and estrogens. It exists in two forms: 5-androstenediol and 4-androstenediol, with 5-androstenediol being the more abundant form in the human body.

In the context of medical definitions, androstenediol is a weak androgen that can be converted into testosterone or estradiol, depending on the needs of the body. It plays a role in the development and maintenance of secondary sexual characteristics, such as facial hair and deepening of the voice in males, and breast development and menstrual cycles in females.

Androstenediol is also available as a dietary supplement and has been marketed for its potential performance-enhancing effects. However, its use as a performance-enhancing drug is banned by many sports organizations due to concerns about its potential to enhance athletic performance and its unknown safety profile.

Analysis of Variance (ANOVA) is a statistical technique used to compare the means of two or more groups and determine whether there are any significant differences between them. It is a way to analyze the variance in a dataset to determine whether the variability between groups is greater than the variability within groups, which can indicate that the groups are significantly different from one another.

ANOVA is based on the concept of partitioning the total variance in a dataset into two components: variance due to differences between group means (also known as "between-group variance") and variance due to differences within each group (also known as "within-group variance"). By comparing these two sources of variance, ANOVA can help researchers determine whether any observed differences between groups are statistically significant, or whether they could have occurred by chance.

ANOVA is a widely used technique in many areas of research, including biology, psychology, engineering, and business. It is often used to compare the means of two or more experimental groups, such as a treatment group and a control group, to determine whether the treatment had a significant effect. ANOVA can also be used to compare the means of different populations or subgroups within a population, to identify any differences that may exist between them.

Hydroxylation is a biochemical process that involves the addition of a hydroxyl group (-OH) to a molecule, typically a steroid or xenobiotic compound. This process is primarily catalyzed by enzymes called hydroxylases, which are found in various tissues throughout the body.

In the context of medicine and biochemistry, hydroxylation can have several important functions:

1. Drug metabolism: Hydroxylation is a common way that the liver metabolizes drugs and other xenobiotic compounds. By adding a hydroxyl group to a drug molecule, it becomes more polar and water-soluble, which facilitates its excretion from the body.
2. Steroid hormone biosynthesis: Hydroxylation is an essential step in the biosynthesis of many steroid hormones, including cortisol, aldosterone, and the sex hormones estrogen and testosterone. These hormones are synthesized from cholesterol through a series of enzymatic reactions that involve hydroxylation at various steps.
3. Vitamin D activation: Hydroxylation is also necessary for the activation of vitamin D in the body. In order to become biologically active, vitamin D must undergo two successive hydroxylations, first in the liver and then in the kidneys.
4. Toxin degradation: Some toxic compounds can be rendered less harmful through hydroxylation. For example, phenol, a toxic compound found in cigarette smoke and some industrial chemicals, can be converted to a less toxic form through hydroxylation by enzymes in the liver.

Overall, hydroxylation is an important biochemical process that plays a critical role in various physiological functions, including drug metabolism, hormone biosynthesis, and toxin degradation.

Penile erection is a physiological response that involves the engagement of the corpus cavernosum and spongiosum (erectile tissue) of the penis with blood, leading to its stiffness and rigidity. This process is primarily regulated by the autonomic nervous system and is influenced by factors such as sexual arousal, emotional state, and certain medications or medical conditions. A penile erection may also occur in non-sexual situations, such as during sleep (nocturnal penile tumescence) or due to other physical stimuli.

Ketosteroids are a type of steroid compound that contain a ketone functional group in their chemical structure. They are derived from cholesterol and are present in both animal and plant tissues. Some ketosteroids are produced endogenously, while others can be introduced exogenously through the diet or medication.

Endogenous ketosteroids include steroid hormones such as testosterone, estradiol, and cortisol, which contain a ketone group in their structure. Exogenous ketosteroids can be found in certain medications, such as those used to treat hormonal imbalances or inflammation.

Ketosteroids have been studied for their potential therapeutic uses, including as anti-inflammatory agents and for the treatment of hormone-related disorders. However, more research is needed to fully understand their mechanisms of action and potential benefits.

"Wistar rats" are a strain of albino rats that are widely used in laboratory research. They were developed at the Wistar Institute in Philadelphia, USA, and were first introduced in 1906. Wistar rats are outbred, which means that they are genetically diverse and do not have a fixed set of genetic characteristics like inbred strains.

Wistar rats are commonly used as animal models in biomedical research because of their size, ease of handling, and relatively low cost. They are used in a wide range of research areas, including toxicology, pharmacology, nutrition, cancer, cardiovascular disease, and behavioral studies. Wistar rats are also used in safety testing of drugs, medical devices, and other products.

Wistar rats are typically larger than many other rat strains, with males weighing between 500-700 grams and females weighing between 250-350 grams. They have a lifespan of approximately 2-3 years. Wistar rats are also known for their docile and friendly nature, making them easy to handle and work with in the laboratory setting.

Desogestrel is a synthetic form of progestin, which is a female sex hormone. It is used in various forms of hormonal contraception such as birth control pills, patches, and vaginal rings to prevent pregnancy. Desogestrel works by preventing ovulation (the release of an egg from the ovaries), thickening cervical mucus to make it harder for sperm to reach the egg, and thinning the lining of the uterus to make it less likely for a fertilized egg to implant.

Desogestrel is also used in some hormone replacement therapies (HRT) to treat symptoms of menopause such as hot flashes and vaginal dryness. It may be prescribed alone or in combination with estrogen.

Like all hormonal contraceptives, desogestrel has potential side effects, including irregular menstrual bleeding, headaches, mood changes, breast tenderness, and nausea. In rare cases, it may also increase the risk of blood clots, stroke, or heart attack. It is important to discuss the risks and benefits of desogestrel with a healthcare provider before using it.

Fertility is the natural ability to conceive or to cause conception of offspring. In humans, it is the capacity of a woman and a man to reproduce through sexual reproduction. For women, fertility usually takes place during their reproductive years, which is from adolescence until menopause. A woman's fertility depends on various factors including her age, overall health, and the health of her reproductive system.

For men, fertility can be affected by a variety of factors such as age, genetics, general health, sexual function, and environmental factors that may affect sperm production or quality. Factors that can negatively impact male fertility include exposure to certain chemicals, radiation, smoking, alcohol consumption, drug use, and sexually transmitted infections (STIs).

Infertility is a common medical condition affecting about 10-15% of couples trying to conceive. Infertility can be primary or secondary. Primary infertility refers to the inability to conceive after one year of unprotected sexual intercourse, while secondary infertility refers to the inability to conceive following a previous pregnancy.

Infertility can be treated with various medical and surgical interventions depending on the underlying cause. These may include medications to stimulate ovulation, intrauterine insemination (IUI), in vitro fertilization (IVF), or surgery to correct anatomical abnormalities.

Saliva is a complex mixture of primarily water, but also electrolytes, enzymes, antibacterial compounds, and various other substances. It is produced by the salivary glands located in the mouth. Saliva plays an essential role in maintaining oral health by moistening the mouth, helping to digest food, and protecting the teeth from decay by neutralizing acids produced by bacteria.

The medical definition of saliva can be stated as:

"A clear, watery, slightly alkaline fluid secreted by the salivary glands, consisting mainly of water, with small amounts of electrolytes, enzymes (such as amylase), mucus, and antibacterial compounds. Saliva aids in digestion, lubrication of oral tissues, and provides an oral barrier against microorganisms."

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... (brand name Lontanyl), or testosterone cyclohexylmethylcarbonate, is an androgen and ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ... anabolic steroid and a testosterone ester. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, ...
Along with testosterone enanthate, testosterone cypionate, and testosterone propionate, testosterone undecanoate is one of the ... Testosterone undecanoate is a testosterone ester and a prodrug of testosterone in the body. Because of this, it is considered ... A related testosterone ester with a similarly very long duration is testosterone buciclate. In the late 1970s, testosterone ... Testosterone undecanoate, or testosterone 17β-undecanoate, is a synthetic androstane steroid and a derivative of testosterone. ...
... (BANTooltip British Approved Name; TiCa), sold under the brand names Sustanon 100, Sustanon 250, and ... List of androgen esters § Testosterone esters Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data ... an androgen and anabolic steroid medication and a testosterone ester which has been used as a component of mixed testosterone ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
The drug was first described in 1936 and was one of the first androgen esters and esters of testosterone to be synthesized. ... Testosterone acetate (brand names Aceto-Sterandryl, Aceto-Testoviron, Amolisin, Androtest A, Deposteron, Farmatest, Perandrone ... Parkes, A.S. (1936). "Increasing the Effectiveness of Testosterone". The Lancet. 228 (5899): 674-676. doi:10.1016/S0140-6736(00 ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
... is a longer-chain ester of testosterone compared to testosterone undecanoate. Relative to testosterone ... Testosterone palmitate, also known as testosterone hexadecanoate, testosterone 17β-palmitate, and androst-4-en-17β-ol-3-one 17β ... However, no free testosterone was observed after administration of testosterone palmitate, suggesting that it is not hydrolyzed ... On the other hand, another study found that testosterone palmitate was hydrolyzed in humans. Testosterone stearate Touitou E, ...
... , also known as testosterone isopentanoate, testosterone 17β-isovalerate, and androst-4-en-17β-ol-3-one ... Testosterone isobutyrate Testosterone isocaproate Testosterone valerate Vitamins and Hormones. Academic Press. 1 January 1944. ... ester of testosterone - which was never marketed. It is a prodrug of testosterone and, when administered via intramuscular ... Testosterone esters, Abandoned drugs, Isovalerate esters, All stub articles, Steroid stubs, Genito-urinary system drug stubs). ...
Testosterone isobutyrate Testosterone palmitate Testosterone propionate Testosterone undecanoate Vitamins and Hormones. ... Testosterone stearate, also known as testosterone octadecanoate, testosterone 17β-stearate, and androst-4-en-17β-ol-3-one 17β- ... Testosterone stearate may occur naturally in the body. It has been said that with longer-chain esters of testosterone like ... ester of testosterone - which was never marketed. It is a prodrug of testosterone and, when administered via intramuscular ...
... is a testosterone ester and a long-lasting prodrug of testosterone in the body. Because of this, it is ... Along with testosterone enanthate, testosterone undecanoate, and testosterone propionate, it is one of the most commonly used ... The pharmacokinetics of testosterone cypionate have been studied and reported. Testosterone cypionate, or testosterone 17β- ... It has also been referred to as testosterone cipionate, as well as testosterone cyclopentylpropionate or testosterone ...
... is a prodrug of testosterone, and hence is an agonist of the androgen receptor, the biological target ... Unlike most other testosterone esters, which are provided as oil solutions, testosterone isobutyrate is formulated as a ... Testosterone isobutyrate has been used in masculinizing hormone therapy for transgender men as well. Testosterone isobutyrate ... Testosterone isobutyrate, or testosterone 17β-(2-methylpropanoate), is a synthetic androstane steroid and a derivative of ...
Major testosterone esters include testosterone cypionate, testosterone enanthate, testosterone propionate, and testosterone ... It is provided unmodified and as a testosterone ester such as testosterone cypionate, testosterone enanthate, testosterone ... "Testosterone Buccal". MedlinePlus. "Testosterone Topical". MedlinePlus. "Testosterone Injection". MedlinePlus. "Testosterone ... Testosterone cypionate: Depo-Testosterone, Testosterone Cypionate (generic) Testosterone enanthate: Delatestryl, Xyosted (auto- ...
Fine goes on to define what 'Testosterone Rex' is and why the idea should be extinct. Testosterone Rex is composed of 3 parts ... Testosterone Rex: Myths of Sex, Science, and Society is the third book written by Cordelia Fine, published in January 2017 by W ... "Testosterone Rex: Unmaking the Myths of Our Gendered Minds". Chemistry World. Rumble, Mel. "Unmaking the Myths of Our Gendered ... Fine, Cordelia (2017). Testosterone Rex: Myths of Sex, Science, and Society. W. W. Norton & Company. pp. 23-24. ISBN 978- ...
Estradiol butyrylacetate/testosterone ketolaurate/reserpine Testosterone propionate/testosterone ketolaurate List of androgen ... Testosterone ketolaurate (INN, USAN) (brand names Androdurin, Testosid-Depot (with testosterone propionate)), also known as ... testosterone caprinoylacetate, is an androgen and anabolic steroid medication and a testosterone ester. It was introduced in ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
... (brand name Andradurin) is an androgen and anabolic steroid and a testosterone ester. ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
Testosterone acetate/testosterone undecanoate/testosterone valerate Testosterone propionate/testosterone valerate/testosterone ... which is marketed in Mexico and also contains testosterone acetate and testosterone undecanoate. Testosterone valerate is a ... Testosterone valerate, or testosterone pentanoate, also known as androst-4-en-17β-ol-3-one 17β-valerate, is a synthetic, ... It is administered via intramuscular injection and acts as a long-lasting prodrug of testosterone. The medication is available ...
... , also known as testosterone carboxylate or testosterone methanoate, as well as androst-4-en-17β-ol-3-one ... List of androgen esters § Testosterone esters Yalkowsky SH, He Y, Jain P (19 April 2016). Handbook of Aqueous Solubility Data, ... Testosterone esters, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ... 17β-formate, is a synthetic, steroidal androgen and an androgen ester - specifically, the C17β formate ester of testosterone - ...
Testosterone acetate Testosterone caproate Testosterone enanthate Yalkowsky SH, He Y, Jain P (19 April 2016). Handbook of ... Testosterone butyrate, or testosterone butanoate, also known as androst-4-en-17β-ol-3-one 17β-butanoate, is a synthetic, ... Its ester side-chain length and duration of effect are intermediate between those of testosterone propionate and testosterone ... Griffiths PJ, James KC, Rees M (1965). "Crystallographic data for some testosterone esters". Acta Crystallographica. 19 (1): ...
... is an endogenous, naturally occurring steroid and minor urinary metabolite of testosterone. Androstanediol ... "Showing metabocard for Testosterone sulfate (HMDB02833)". Human Metabolome Database, HMDB. 5.0. v t e v t e (Articles without ... Testosterone esters, All stub articles, Steroid stubs, Biochemistry stubs). ... glucuronide Androsterone glucuronide Etiocholanolone glucuronide Testosterone glucuronide Wishart, David S.; Guo, An Chi; Oler ...
... heptanoate/testosterone caproate Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone ... Testosterone caproate (TCa), also known as testosterone hexanoate, is an androgen and anabolic steroid and a testosterone ester ... The Russian Testosterone Hexanoate 100 mg (front) The Russian Testosterone Hexanoate 100 mg (back) List of androgen esters § ... It was formerly available as a component of Omnadren 250, along with testosterone isocaproate, testosterone phenylpropionate, ...
Methyl-1-testosterone is the 17α-methyl derivative of 1-testosterone. Doping with 1-testosterone can be detected in urine ... unlike testosterone propionate, 1-testosterone also increases liver weight. 1-Testosterone, IUPAC name 17β-hydroxy-5α-androst-1 ... Mesabolone is a ketal made from 1-testosterone. 1-Testosterone also is known to be used to synthesize mestanolone and ... Δ1-testosterone). It differs from testosterone by having a 1(2)-double bond instead of a 4(5)-double bond in its A ring. It was ...
The introduction of longer-acting testosterone esters like testosterone enanthate, testosterone cypionate, and testosterone ... Testosterone propionate is a testosterone ester and a relatively short-acting prodrug of testosterone in the body. Because of ... Testosterone propionate, or testosterone 17β-propanoate, is a synthetic androstane steroid and a derivative of testosterone. It ... In the 1950s, longer-acting testosterone esters like testosterone enanthate and testosterone cypionate were introduced and ...
... but noted that a study about testosterone and male employment had shown that testosterone levels were lower for successful new ... found a significant positive relationship between levels of testosterone and aggression. However, the link between testosterone ... Karl Albrecht made testosterone poisoning a synonym for male chauvinism in his 2002 book The Power of Minds at Work: ... What is not so well known, is that men have an overdose... Until recently it has been thought that the level of testosterone in ...
... (BANTooltip British Approved Name; TPP) (brand name Testolent), or testosterone phenpropionate, ... Testosterone phenylpropionate was also notably a component of Sustanon and Omnadren, as well as of Estandron Prolongatum, ... ISBN 978-0-9828280-1-4. Dekansi J, Chapman RN (September 1953). "Testosterone phenyl propionate (TPP): biological trials with a ... Testosterone esters, Substances discovered in the 1950s, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
... is an endogenous, naturally occurring steroid and minor urinary metabolite of testosterone. ... "Showing metabocard for Testosterone glucuronide (HMDB03193)". Human Metabolome Database, HMDB. 5.0. v t e v t e (Articles ... Androstanediol glucuronide Androsterone glucuronide Etiocholanolone glucuronide Testosterone sulfate Wishart, David S.; Guo, An ... Testosterone, Glucuronide esters, Human metabolites, All stub articles, Steroid stubs, Biochemistry stubs). ...
... (TPA; brand names Perandren, Androject) is an androgen and anabolic steroid and a testosterone ester ... However, since its introduction, it has largely been replaced by other esters, such as testosterone propionate. Testosterone ... 300 mg testosterone propionate in aqueous suspension had a duration of 13 days, 353 mg testosterone cypionate in oil solution ... testosterone phenylacetate was one of the first testosterone esters to be introduced. ...
Look up testosterone in Wiktionary, the free dictionary. Testosterone is a naturally occurring male sex hormone. Testosterone ... Testosterone, a 1995 album by Bill Davis Testosterone, a 1992 EP by Zonic Shockum "Testosterone", a 1995 song by Bush from " ... American film Testosterone (novel), 2000 novel by James Robert Baker and the basis for the film Testosterone (2004 film), Greek ... the hormone used as a medication Testosterone (patch), a medical patch designed to treat female sexual dysfunction Testosterone ...
... (THHB), or testosterone cyclohexanecarboxylate (TCHC), sold under the brand names Testormon ... THHB has comparable pharmacokinetics to those of testosterone cypionate and testosterone enanthate. The medication is no longer ... Behre HM, Nieschlag E, Behre H, Nieschlag S (26 July 2012). "Testosterone preparations for clinical use in males". In Nieschlag ... is an androgen and anabolic steroid medication and a testosterone ester. It is used by intramuscular injection and is provided ...
It is a component of Sustanon, along with testosterone propionate, testosterone phenylpropionate, and testosterone isocaproate ... Testosterone decanoate (BANTooltip British Approved Name) is an androgen and anabolic steroid and a testosterone ester. ... It has a longer duration of action than testosterone enanthate, but its duration is not as prolonged as that of testosterone ... Testosterone decanoate has been investigated as a potential long-acting injectable male contraceptive. ...
Administration of testosterone beta-cyclopentylpropionate, testosterone furanate, and testosterone oenanthate". Acta Endocrinol ... Testosterone furoate (brand name Furotest), also referred to as testosterone furanate in some publications, is an androgen and ... List of androgen esters § Testosterone esters Hamburger C (August 1956). "Testosterone treatment and 17-ketosteroid excretion. ... Testosterone esters, 2-Furyl compounds, All stub articles, Genito-urinary system drug stubs, Steroid stubs). ...
Testosterone patches works by releasing the hormone testosterone through the skin into the bloodstream. In women, testosterone ... Testosterone therapy is systemic and needs to be applied over a period of weeks or months to have an effect. P&G licensed the ... The testosterone patch, brand name Intrinsa among others, was designed to treat female sexual dysfunction. ... In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from ...
"Testosterone Products: Drug Safety Communication - FDA Cautions About Using Testosterone Products for Low Testosterone Due to ... testosterone which is not bound to SHBG is called free testosterone. It seems that only the free amount of testosterone can ... of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by ... Testosterone levels do not rely on physical presence of a partner; testosterone levels of men engaging in same-city and long- ...
Low testosterone is associated with other medical conditions, such as diabetes, obesity, heart disease, depression, and ... Testosterone and Heart Disease. Testosterone has mixed effects on the arteries. Many experts believe testosterone contributes ... testosterone replacement improved blood sugar levels and obesity in men with low testosterone. However, testosterone therapy ... Testosterone helps the bodys tissues take up more blood sugar in response to insulin. Men with low testosterone more often ...
Learn more about some of the foods that lower testosterone here. ... Soy products, dairy, and alcohol all reduce testosterone. ... Testosterone is one of the major sex hormones in the body. Although men produce more testosterone, it is an important hormone ... Could low-fat diets reduce testosterone levels in men?. Doctors often recommend that men with testosterone deficiency lose ... Can Foods Lower Testosterone?. Medically reviewed by Alissa Palladino, MS, RDN, LD, CPT, Nutrition, Personal Training - By Jon ...
See examples of TESTOSTERONE used in a sentence. ... Testosterone is produced mainly in the testes and is also used ... The hormonal fuel for both impulses is the same: testosterone.. Why These Marines Love Frozen-and Why It Matters , Aaron B. ... testosterone. in a sentence. *. Feminizing hormone therapy involves taking estrogen through a pill, patch or injection, often ... In the male-dominated, testosterone-fueled market of 1960s New York real estate, Cecilia Benattar was in a class all her own. ...
Pubertal Testosterone and Brain Response to Faces in Young Adulthood: An Interplay between Organizational and Activational ...
Testosterone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Testosterone should not be used treat the symptoms of low testosterone in men who have low testosterone due to aging (age- ... Testosterone is used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not ... Before taking testosterone,. *tell your doctor and pharmacist if you are allergic to testosterone, any other medications, or ...
In such cases it may be that males show a similar reduced testosterone level while women do not. While there are slightly more ... Haha, Id love to see the reactions of a few teabaggers being told that they probably have much lower testosterone levels than ... The researchers suggest that perhaps female testosterone is more difficult to record in women and doesnt have the same rapid ... The authors further speculate that a similar reduction in testosterone may also apply in the case of business or union ...
New research suggests that testosterone may make us more aggressive without us consciously feeling any aggression. Christie ... Testosterone has a lot of roles-some good, some perhaps counterproductive. Now research suggests that testosterone can make ... Study participants received testosterone or a placebo and then were shown color-tinted faces of men and women. The faces had ... Those who got the testosterone boost diverted their gaze from the angry faces more slowly than from the happy or neutral faces- ...
... is mainly used to treat low testosterone levels caused by a medical condition or aging. ... testosterone gel Testosterone gel is a topical medication containing testosterone and is prescribed for the treatment of low ... Low Testosterone (Low T) Treatments. What causes low testosterone (low T)? Learn about low testosterone symptoms in men. ... Testosterone is used to treat low testosterone levels. Common side effects of testosterone include pain and inflammation at the ...
Combatting declining testosterone is easier than you think. ... Hack Your Testosterone. 5 Easy Ways To Hack Your Testosterone. ... Its more important than ever to keep your testosterone up these days. The average testosterone level of American men has ... Fortunately, there are ways to combat declining testosterone. Here are 5 hacks to boost your testosterone naturally. ... Testosterone Health New Research Suggests Frequent Male Orgasms Might Cut Your Risk of Prostate Cancer ...
If you have low testosterone, testosterone replacement therapy might be an option for you. Learn about its risks and benefits. ... Can Testosterone Supplements Improve Your Sex Drive?. Get the details on testosterone boosters, or supplements that aim to ... Testosterone also contributes to vitality and well-being.. As men age, their bodies gradually produce less testosterone. This ... Testosterone decreases each year after age 30. Learn about causes such as hypogonadism, and treatments such as testosterone ...
Kyzatrex (testosterone undecanoate) is an oral formulation of testosterone, an endogenous androgen. Testosterone and ... Kyzatrex (testosterone undecanoate) is a proprietary softgel oral formulation of testosterone, an androgen. ... Adjust the dosage to a minimum of 100 mg once in the morning and a maximum of 400 mg twice daily based on serum testosterone ... Secondary endpoints were also reached: The percentage of patients who received KYZATREX and had testosterone Cmax threshold ...
A meta-analysis may provide some reassurance of the short-term cardiovascular safety of testosterone therapy for male ... Testosterone Therapy for Hypogonadism With Diabetes? * Former British Cycling Doctor Denies Putting Own Ambition Before Riders ... Testosterone concentrations progressively decline in men with advancing age, at about 2% per year, Michos and Budoff write. In ... Testosterone replacement therapy has been used to increase libido, improve erectile dysfunction, and boost energy levels, mood ...
Testosterone replacement therapy raises the bodys testosterone levels through regular administration of testosterone. Various ... What is Testosterone Deficiency Syndrome?. Testosterone Deficiency Syndrome, or male hypogonadism, occurs when the body does ... Testosterone deficiency is typically diagnosed with a simple blood test.. When a specific cause for testosterone deficiency is ... Testosterone plays a key role in an individuals sex drive, muscle mass, and mental and physical energy.. This condition ...
Testosterone Use in Women Common; Evidence Commonly Weak Although Davis stressed that any use of testosterone should be avoided ... Adjust Male Formulations of Testosterone Accordingly for Female Dose Existing testosterone preparations are only designed for ... The report addresses potential cardiovascular risks of testosterone. It indicates that oral testosterone therapy is associated ... Clinicians commonly prescribe testosterone to women off label for HSDD, as well as for a variety of other symptoms, including ...
When City traders have high morning testosterone levels they make more than average profits for the rest of that day, ... Testosterone is a steroid hormone which controls competitive encounters as well as sexual behaviour. Testosterone in male ... However, if testosterone reaches physiological limits, as it might during a market bubble, it can turn risk-taking into a form ... This increase of testosterone in the winner can increase confidence and risk taking and improve chances of winning yet again, ...
Take this Low T Quiz to learn the causes and symptoms of low testosterone and what can be done about it. ... Did you know that low testosterone can affect both men and women? ... In men, low testosterone levels in the body can be supplemented by hormone replacement with testosterone. Testosterone ... Losing weight through exercise can increase testosterone levels. Testosterone supplements in men with low testosterone also can ...
A new study anthropologists suggests that the hormone testosterone -- specifically, an unnatural overabundance thereof -- may ... Increased diabetes risk has been connected to higher levels of testosterone to prostate enlargement, a new study reports. ... Testosterone Promotes Cuddling, Not Just Aggression, Animal Study Finds. Aug. 12, 2022 Testosterone can foster friendly, ... Despite having low testosterone overall, Tsimane men with higher testosterone levels (but still significantly lower than those ...
Testosterone topical gel is used for the treatment of males whose bodies do not make enough natural testosterone, a condition ... Testosterone may cause edema (fluid retention) in patients with these conditions. Proper Use. This medicine comes with a ... Testosterone may cause birth defects if a pregnant woman comes in contact with the medicine. Make sure your doctor knows if ... Testosterone is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary ...
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed ... TESTOSTERONE CYPIONATE (UNII: M0XW1UBI14) (TESTOSTERONE - UNII:3XMK78S47O) TESTOSTERONE CYPIONATE. 200 mg in 1 mL. ... testosterone cypionate 200 MG/ML Injectable Solution. PSN. 2. 835840. testosterone cypionate 200 MG/ML Injectable Solution. SCD ... Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. ...
English Translation for testosterone levels - dict.cc German-English Dictionary ... testosterone injection. testosterone level. • testosterone levels. testosterone ointment. testosterone patch. testosterone ... testosterone production. testosterone propionate. testosterone resistance. testosterone therapy. testosterone value. test out. ... testosterone. testosterone concentration. testosterone cream. testosterone deficiency. testosterone derivative. ...
Preliminary real-world audit data show reduced A1c among men who received testosterone replacement therapy over a 2-year period ... studies that 60 percent of people who didnt respond were testosterone deficient. After being given testosterone, they ... in that diabetes type 2 and obesity lower testosterone concentrations. Weight loss of 5%-10% may raise testosterone ... Testosterone Therapy for Hypogonadism With Diabetes? * Former British Cycling Doctor Denies Putting Own Ambition Before Riders ...
Learn the most common signs of low testosterone in men. ... Testosterone is a hormone produced by the human body. ... Low testosterone is when testosterone levels fall below 300 ng/dL. A blood test called a serum testosterone test can determine ... Testosterone replacement therapy is a common treatment for low testosterone. If low testosterone symptoms are bothering you, ... on testosterone supplementation did not find memory improvements in 493 men with low testosterone levels who took testosterone ...
... and free testosterone. Albumin and SHBG are proteins that bind to testosterone, while free testosterone is not protein-bound. ... What Is Testosterone And How Does It Work? Your Ultimate Guide To Understanding Testosterone Jorden Pagel ... And testosterone has a big effect on our sexual health. Taking the necessary steps to ensure optimal testosterone levels will ... Healthy Testosterone Levels The range for what is considered a "normal" level of testosterone is actually quite large. For men ...
Although the definition of a low testosterone level varies among guidelines, a serum total testosterone level of less than 300 ... To receive exogenous testosterone replacement therapy (TRT), patients should meet criteria for hypogonadism, which is defined ... Numerous testosterone formulations are available, ranging from topical gels to intramuscular injections. The choice of ... When the testes fail to produce an adequate level of endogenous testosterone, men develop hypogonadism. ...
Women athletes with high levels of testosterone will have to take hormone suppressants in order to be eligible for certain ... To put that in perspective, 5 nmol/L is three times greater than the upper limit of normal testosterone in women, Clare ... Considering testosterone can aid in muscle growth and oxygen-carrying capacity, the rationale is that athletes - specifically ... According to these new rules, athletes have seven days to lower their testosterone levels below 5 nmol/L, the restricted limit ...
Shortages of testosterone and other medicines are not unusual. There was a short-term interruption to the supply of Pfizers ... Maphosa said he used up his last shot of testosterone at the end of September and hasnt been able to find anything since then ... Accessing testosterone and hormone replacement therapy has been a life and gender-reaffirming experience for Mpofu. But despite ... Maphosa said he was aware of people offering vials of testosterone on the black market and if he wasnt able to access ...
This article talks about how to increase and boost testosterone level naturally with food too. ... Ways to Increase Testosterone Naturally. Effects of low testosterone:. An imbalance of testosterone results in low sex drive, ... Ways to Increase Testosterone NaturallyEffects of low testosterone:An imbalance of testosterone resu.... Read More ... Ways to Increase Testosterone Naturally. What is testosterone:. It is a hormone that is secreted from the testes and important ...
Post-menopausal women have better memory after daily treatment with a testosterone spray for six months, a new preliminary ... Does Testosterone Influence Success? Not Much, Research Suggests. July 28, 2021 With the Olympics underway, higher testosterone ... But beyond sport, new research has found little evidence that testosterone ... Testosterone Has a Complicated Relationship With ... who knowingly received the testosterone spray on their skin. The spray dose returned testosterone levels in the blood to those ...
This testosterone is called free testosterone. Free testosterone and albumin-bound testosterone are also referred to as ... Total Testosterone. Does this test have other names?. Testosterone (total), serum testosterone, free testosterone ... This looks at all 3 types of testosterone. The free testosterone can help give more information when total testosterone is low ... Testosterone also causes a boys voice to deepen. Males continue to make testosterone. In adult males, it boosts sex drive and ...
  • page needed] In addition to its role as a natural hormone, testosterone is used as a medication to treat hypogonadism, breast cancer, and gender dysphoria. (wikipedia.org)
  • Testosterone is used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). (medlineplus.gov)
  • Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland, (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. (medlineplus.gov)
  • Some men have a testosterone deficiency called male hypogonadism . (healthline.com)
  • If you have male hypogonadism or low testosterone, talk with your doctor about whether TRT may be a good option for you. (healthline.com)
  • Prior to initiating Kyzatrex, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these concentrations are below the normal range. (centerwatch.com)
  • Male hypogonadism, a clinical syndrome resulting from insufficient secretion of testosterone, has two main etiologies. (centerwatch.com)
  • Despite a new meta-analysis claiming to show that testosterone replacement therapy for men with hypogonadism does not increase the risk of cardiovascular outcomes such as myocardial infarction or stroke, experts say the jury is still out. (medscape.com)
  • In 2014, the US Food and Drug Administration (FDA) mandated a label on testosterone products warning of possible increased cardiovascular risks and to reserve the therapy for symptomatic hypogonadism only. (medscape.com)
  • In contrast, the European Medicines Agency concluded that when hypogonadism is properly diagnosed and managed, there is currently no clear, consistent evidence that testosterone therapy causes increased cardiovascular risk . (medscape.com)
  • To address this uncertainty, Hudson and colleagues formed a global collaborative to obtain individual patient data on cardiovascular outcomes from randomized controlled trials of testosterone therapy for men with hypogonadism. (medscape.com)
  • This is "the most comprehensive study to date investigating the safety of testosterone treatment of hypogonadism," according to the researchers. (medscape.com)
  • The current results provide some reassurance about the short-term to medium-term safety of testosterone to treat male hypogonadism," they conclude. (medscape.com)
  • We should continue to use caution as indicated by the FDA label and only use testosterone therapy selectively in people who have true symptoms of hypogonadism," and be cautious about using it particularly in men at higher cardiovascular risk due to family history or known personal heart disease. (medscape.com)
  • Testosterone Deficiency Syndrome, or male hypogonadism, occurs when the body does not produce enough testosterone, the main male hormone. (rochester.edu)
  • Testosterone topical gel is used for the treatment of males whose bodies do not make enough natural testosterone, a condition called hypogonadism. (mayoclinic.org)
  • Low testosterone (male hypogonadism) is a condition in which your testicles don't produce enough testosterone. (clevelandclinic.org)
  • Any issue with your testicles, hypothalamus or pituitary gland can cause low testosterone (male hypogonadism). (clevelandclinic.org)
  • Who does low testosterone (male hypogonadism) affect? (clevelandclinic.org)
  • In addition, their labels would be modified to clarify current approved uses, as testosterone replacement is only indicated to treat men who suffer from hypogonadism (low testosterone levels) due to disorders of the testicles, pituitary gland, or brain. (prweb.com)
  • Low levels of testosterone (known as low T, or hypogonadism) is a male problem. (everydayhealth.com)
  • Testosterone is determined in men when reduced testosterone production is suspected, e.g. in hypogonadism, estrogen therapy, chromosome aberrations (as in the Klinefelter's syndrome) and liver cirrhosis. (cdc.gov)
  • Harmonized reference normal ranges for testosterone levels in healthy, nonobese men have been generated in a landmark study that should aid in accurately diagnosing hypogonadism , say US investigators. (medscape.com)
  • The diagnosis of hypogonadism, which is characterized by low testosterone levels and can lead to sexual dysfunction, decreased bone and muscle strength, and lower fertility, relies on accurate hormonal measurements. (medscape.com)
  • Another recent study has suggested that measuring free testosterone alongside total testosterone may offer a more accurate picture when diagnosing hypogonadism. (medscape.com)
  • As reported by Medscape Medical News , analysis of 3000 men in eight European countries indicated that men with normal total testosterone but low free testosterone levels had more signs and symptoms of hypogonadism than those with low total-testosterone levels only. (medscape.com)
  • Since testosterone levels decrease as men age, testosterone is sometimes used in older men to counteract this deficiency. (wikipedia.org)
  • Diabetes, metabolic syndrome, and obesity have all been linked to testosterone deficiency. (webmd.com)
  • But testosterone deficiency is connected to insulin resistance , obesity, and diabetes. (webmd.com)
  • a commercially prepared form of the sex hormone C 19 H 28 O 2 , originally isolated from bull's testes and now also produced synthetically, used in medicine chiefly for treatment of testosterone deficiency and for certain gynecological conditions. (dictionary.com)
  • Kyzatrex is specifically indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone. (centerwatch.com)
  • Unlike menopause, testosterone deficiency syndrome is not an inevitable result of aging. (rochester.edu)
  • Testosterone deficiency syndrome can contribute to the start or worsening of various diseases. (rochester.edu)
  • Testosterone deficiency is typically diagnosed with a simple blood test. (rochester.edu)
  • When a specific cause for testosterone deficiency is identified, treatment can be focused on that cause. (rochester.edu)
  • And if they fulfill criteria for testosterone deficiency and have had their [prostate-specific antigen] checked, consider a trial of treatment and follow them," study lead author T. Hugh Jones, MD, consultant physician and endocrinologist at Barnsley Hospital NHS Foundation Trust, Barnsley, United Kingdom advised, speaking with Medscape Medical News . (medscape.com)
  • Testosterone deficiency is also associated with adverse effects on cardiovascular risk factors, bone health, muscle strength, sexual function, and psychological well-being, yet it is often overlooked, Jones noted. (medscape.com)
  • In the meantime, he said, giving testosterone replacement to men with deficiency can be very rewarding for many reasons. (medscape.com)
  • Testosterone Deficiency in Younger Men - Is It Real? (zrtlab.com)
  • Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. (medscape.com)
  • Fat cells metabolize testosterone to estrogen , lowering testosterone levels. (webmd.com)
  • For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone. (wikipedia.org)
  • Less SHBG means less free testosterone. (webmd.com)
  • Testosterone esters are less polar than free testosterone. (nih.gov)
  • Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life. (nih.gov)
  • There are actually three different kinds of testosterone floating around your blood: albumin, sex hormone binding globulin (SHBG), and free testosterone. (askmen.com)
  • Albumin and SHBG are proteins that bind to testosterone, while free testosterone is not protein-bound. (askmen.com)
  • Typically, there are two ways to measure testosterone levels: A total testosterone test, which measures the combined levels of all three types in your blood, or a test that only measures free testosterone. (askmen.com)
  • For men, normal levels of total testosterone fall between 300 and 1000 nanograms per deciliter (ng/dl), with normal free testosterone levels falling between 9 and 30 ng/dl. (askmen.com)
  • In addition, total testosterone levels may be at an acceptable level, but free testosterone could be low - leading to symptoms of low T. That's why it's important to have both your total and free testosterone levels checked. (askmen.com)
  • This testosterone is called free testosterone. (rochester.edu)
  • Free testosterone and albumin-bound testosterone are also referred to as bioavailable testosterone. (rochester.edu)
  • The free testosterone can help give more information when total testosterone is low. (rochester.edu)
  • A study in the journal Nutrients linked a diet high in bread, pastries, and other desserts to low total testosterone levels in Taiwanese men. (medicalnewstoday.com)
  • Furthermore, the statement recommends that blood total testosterone levels not be used to diagnose HSDD. (medscape.com)
  • If your healthcare provider thinks that you have low or high testosterone, they will first test total testosterone levels. (rochester.edu)
  • The new findings, which are based on measurements taken from over 9000 men and calibrated against a US Centers for Disease Control and Prevention (CDC) standardized assay, offer, for the first time, a reliable baseline for total testosterone levels. (medscape.com)
  • Do certain foods lower testosterone? (medicalnewstoday.com)
  • Can Foods Lower Testosterone? (medicalnewstoday.com)
  • Some foods, including soy, dairy, and specific fats, have been claimed to lower testosterone levels in the body. (medicalnewstoday.com)
  • However, it is important to note that the research regarding food's ability to lower testosterone levels is limited. (medicalnewstoday.com)
  • Among them, athletes must demonstrate lower testosterone levels for 12 months before competing, and athletes can only qualify four years after transitioning, at the earliest. (dictionary.com)
  • Haha, I'd love to see the reactions of a few teabaggers being told that they probably have much lower testosterone levels than the liberals they so revile. (scienceblogs.com)
  • Asked to comment, endocrinologist Bradley D. Anawalt, MD, chief of medicine at the University of Washington Medical Center, Seattle, told Medscape Medical News , "This 'worldwide survey' confirms many studies from around the world over the past 20 years… [T]he association is due to 'reverse causation,' in that diabetes type 2 and obesity lower testosterone concentrations. (medscape.com)
  • Although men with children often have lower testosterone levels than men without children, earlier studies were not always successful in finding a link between fathers' direct involvement with their children and their testosterone levels. (vice.com)
  • Individuals with lower testosterone levels were more inclined to enjoy what the researchers labeled as "sophisticated music," a genre that included both classical and jazz. (newsweek.com)
  • When some men experience sexual difficulties, they might be tempted to point the finger at lower testosterone levels , and might even wonder if too much masturbation is to blame. (captivsenses.com)
  • While lower testosterone levels could, possibly, be contributing to a lack of sexual desire , those low levels have nothing to do with how much you masturbate. (captivsenses.com)
  • the societal guilt can mix in with normal stress and anxiety from daily life to severely lower testosterone levels. (captivsenses.com)
  • The paper notes that many studies have not found a connection between eating soy products and altered serum testosterone or estrogen levels. (medicalnewstoday.com)
  • A serving of sugar equal to that in a bottle of soda can decrease serum testosterone levels by 25% within an hour, and by even more within 2 hours. (askmen.com)
  • Adjust the dosage to a minimum of 100 mg once in the morning and a maximum of 400 mg twice daily based on serum testosterone drawn 3 to 5 hours after the morning dose at least 7 days after starting treatment or following dose adjustment and periodically thereafter. (centerwatch.com)
  • To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men selected for the 1/3 subsample where organochlorine pesticide levels were determined. (cdc.gov)
  • This yielded a cohort of 9054 community-dwelling adult men with serum testosterone levels. (medscape.com)
  • As each study had used different assays for measuring testosterone, with each assay using different calibrators, the team obtained fasting morning serum samples from 100 men in each cohort, which were then analyzed in the CDC Clinical Reference Laboratory using a single, highly calibrated assay. (medscape.com)
  • Problems with erections and libido (sexual desire) are common symptoms of low testosterone. (webmd.com)
  • Testosterone may control your symptoms but will not cure your condition. (medlineplus.gov)
  • Symptoms of this condition in present-day males, known as Klinefelter syndrome, include low testosterone , lack of facial and body hair, enlarged breasts and learning and language-related problems. (dictionary.com)
  • It's still not indicated in people just for a low number [for blood testosterone] with less severe symptoms. (medscape.com)
  • Existing evidence clearly shows that testosterone is beneficial in the treatment of sexual desire dysfunction in postmenopausal women, but not for any other conditions or symptoms, the authors conclude. (medscape.com)
  • An upsurge in media attention regarding the so-called "male menopause" has left many men rushing to their doctor to treat symptoms they believe may be related to low levels of testosterone. (rxlist.com)
  • The thought behind the concept of male menopause is that the decline in testosterone levels that occurs as men age may produce a characteristic and potentially treatable set of symptoms. (rxlist.com)
  • While people assigned male at both and people assigned female at birth produce testosterone, this article focuses on symptoms of low testosterone in people who were assigned male at birth. (healthline.com)
  • If your testosterone production drastically drops, you may experience a range of symptoms. (healthline.com)
  • However, since taking natural steps to increase my testosterone (which I will talk about later in the article), my symptoms have disappeared and I have more energy and sexual desire than ever. (askmen.com)
  • You may need this test if you have symptoms of low testosterone. (rochester.edu)
  • Symptoms of low testosterone can vary considerably, particularly by age and how severe it is. (clevelandclinic.org)
  • Low testosterone causes different symptoms at different ages. (clevelandclinic.org)
  • Providers also take symptoms into consideration when diagnosing low testosterone. (clevelandclinic.org)
  • What are the symptoms of low testosterone? (clevelandclinic.org)
  • Symptoms of low testosterone can vary considerably, particularly by age. (clevelandclinic.org)
  • The FDA said it had become aware that prescription testosterone treatments were being used extensively to relieve symptoms in men who have low testosterone for no apparent reason other than aging. (prweb.com)
  • Learn more about the symptoms of high testosterone and how it's treated. (everydayhealth.com)
  • Could behaviors like aggressive sexuality, the need for power, volatility, and competitiveness be symptoms of high testosterone? (everydayhealth.com)
  • Many people mistake the symptoms of anabolic steroid abuse with symptoms of high testosterone," he says. (everydayhealth.com)
  • The reason you see symptoms like shrunken testicles and breast enlargement is because a lot of excess testosterone is converted to the female hormone estrogen," Drincic says. (everydayhealth.com)
  • The only behavior symptoms I have seen from treating with too much testosterone are mood swings, which is only with testosterone injections . (everydayhealth.com)
  • Dietary and exercise changes, particularly limiting sugars, especially fructose, eating healthy saturated fats, and engaging in high-intensity exercises may relieve symptoms of low testosterone ,' Lucille says. (everydayhealth.com)
  • While it's true that abnormal lab findings can contribute to symptoms - high thyroid-stimulating hormone reflects hypothyroidism, high testosterone reflects polycystic ovary syndrome, and hyperandrogenism or low cortisol may contribute to fatigue. (zrtlab.com)
  • The consensus statement recommends that "male formulations can be used judiciously in small doses, with blood testosterone concentrations monitored regularly. (medscape.com)
  • Importantly, treatment should target blood concentrations of testosterone that approximate what is normal for premenopausal women, and no higher, the statement recommends. (medscape.com)
  • Weight loss of 5%-10% may raise testosterone concentrations in men with high body mass indices, large waist circumferences, and low blood testosterone concentrations. (medscape.com)
  • With research showing that winning sports games and games of chance boosted testosterone concentrations, we wondered if money might induce a similar hormonal response, and if so, how might these changes impact risk preferences. (irishtimes.com)
  • However, Stenstrom notes that not all forms of risk-taking are detrimental: "If someone is hoping to boost their confidence sufficiently to take a risk that could positively impact their life - perhaps leave a safe job to start a new business - then handling money might help boost their testosterone concentrations and nudge them towards starting that new venture. (irishtimes.com)
  • They set up an experiment in which 104 male students were investigated to determine whether handling and sorting money - 80 $20 bills - compared to just paper, would change their testosterone concentrations and influence their financial risk-taking. (irishtimes.com)
  • The researchers discovered a relationship between salivary testosterone concentrations when men were handling money, and their degree of narcissism as measured by a standardised psychological test. (irishtimes.com)
  • They found when men with low narcissistic traits were randomly assigned to handle money, their salivary testosterone concentrations rose, compared to their counterparts engaged in a non-money handling task. (irishtimes.com)
  • By contrast, when men with high narcissistic traits handled money, their salivary testosterone concentrations remained relatively low. (irishtimes.com)
  • Albumin, which exists in far higher concentrations than SHBG, also binds sexual steroids - although with a clearly lower binding affinity (e.g. about 100 times lower for testosterone). (cdc.gov)
  • Prostate-specific antigen (PSA) concentrations in hypogonadal men during 6 years of transdermal testosterone treatment. (medscape.com)
  • RÉSUMÉ Afin de déterminer les effets du jeûne du ramadan sur la sécrétion d'hormones sexuelles chez des hommes célibataires en bonne santé, nous avons mesuré les concentrations sanguines de testostérone et d'hormones lutéinisante (LH) et folliculostimulante (FSH) chez 52 étudiants célibataires âgés de 18 à 24 ans qui jeûnaient pendant 12 heures ou plus pendant le ramadan. (who.int)
  • Testosterone helps the body's tissues take up more blood sugar in response to insulin . (webmd.com)
  • Food powers the cells and may affect some of the body's other components, including hormones, such as testosterone. (medicalnewstoday.com)
  • Your doctor may order certain tests to check your body's response to testosterone. (medlineplus.gov)
  • Feminizing hormone therapy involves taking estrogen through a pill, patch or injection, often with a separate drug to block the body's natural testosterone . (dictionary.com)
  • Testosterone replacement therapy raises the body's testosterone levels through regular administration of testosterone. (rochester.edu)
  • But, you may be able to restore your body's ability to create testosterone by using the finest testosterone booster. (washingtoncitypaper.com)
  • Testosterone is the primary male sex hormone and androgen in males. (wikipedia.org)
  • In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors. (wikipedia.org)
  • Kyzatrex (testosterone undecanoate) is a proprietary softgel oral formulation of testosterone, an androgen. (centerwatch.com)
  • Testosterone is a male sex hormone (androgen) that helps male features develop. (rochester.edu)
  • Testosterone is the main androgen . (clevelandclinic.org)
  • The androgen testosterone (17ß-hydroxyandrostenone) has a molecular weight of 288 daltons. (cdc.gov)
  • Testosterone is one of the major sex hormones in the body. (medicalnewstoday.com)
  • Typically, the body does an effective job regulating the hormones and keeping levels of testosterone where they need to be. (medicalnewstoday.com)
  • By eating a diet high in cholesterol, you're giving your body the raw materials to synthesize testosterone, along with a number of other crucial hormones. (askmen.com)
  • Testosterone production is regulated by hormones released from the brain. (rxlist.com)
  • Testosterone is part of a group of hormones called androgens, or steroid hormones. (askmen.com)
  • As a man, there are fewer hormones more important than testosterone in your body. (askmen.com)
  • An international team of economists and neuroscientists write in Nature that the hormones cortisol and testosterone can affect men's optimism and preferences for risky investments, and might play a role in destabilizing financial markets. (mentalfloss.com)
  • In the trials with administered cortisol and testosterone, both hormones increased men's investment in higher risk stocks. (mentalfloss.com)
  • Worried that too much stroking could flood your body with too much testosterone, or maybe depletes or decreases the hormones responsible for things like body and facial hair, muscle building and libido? (captivsenses.com)
  • Delivery of the bioidentical hormones estradiol (E2), progesterone (Pg), and testosterone (T) through the skin as a cream or gel (topically) has become a mainstay of bioidentical hormone replacement therapy (BHRT) for women and men. (zrtlab.com)
  • ABSTRACT To determine the effects of Ramadan fasting on the secretion of sex hormones in single healthy males, we measured blood hormone levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 52 single male students aged 18-24 years who were fasting for 12 hours during Ramadan. (who.int)
  • A certain amount of testosterone may be necessary for healthy arteries because it's converted into estrogen , which protects arteries from damage. (webmd.com)
  • Your doctor may adjust your dose of testosterone depending on the amount of testosterone in your blood during your treatment and your reaction to the medication. (medlineplus.gov)
  • The pituitary gland in your brain controls the amount of testosterone your body makes. (rochester.edu)
  • Your hypothalamus and pituitary gland normally control the amount of testosterone your testicles produce and release. (clevelandclinic.org)
  • A person can also increase testosterone levels naturally, by exercising regularly and maintaining a healthy weight. (medicalnewstoday.com)
  • Here are 5 hacks to boost your testosterone naturally. (askmen.com)
  • The influence of steroids naturally produced in the body (specifically testosterone and cortisol) may also provide insight into why people caught up in bubbles and crashes often find it difficult to make rational choices, unintentionally exacerbating financial crises. (cam.ac.uk)
  • Many people believe testosterone levels naturally decline with age. (askmen.com)
  • Try out these steps to naturally increase testosterone level. (indiatimes.com)
  • Testosterone levels in adults AMAB naturally decline as they age. (clevelandclinic.org)
  • Levels of testosterone are naturally much higher in people assigned AMAB than in people assigned female at birth (AFAB). (clevelandclinic.org)
  • Strength training, reducing stress , and optimizing vitamin D levels can also be very effective at boosting testosterone levels naturally. (everydayhealth.com)
  • During arousal, whether you are using your right-hand man, a masturbation toy for men specifically, or having sexual intercourse , your body naturally and temporarily tops up your testosterone levels. (captivsenses.com)
  • The IAAF argued that high, naturally occurring levels of testosterone in athletes like Semenya with "intersex" characteristics that don't conform to standard definitions of male and female give them an unfair competitive advantage, and it decreed a maximum level for females. (nbclosangeles.com)
  • According to the IAAF, most females, including elite athletes, have levels of testosterone circulating naturally in their bodies of 0.12 to 1.79 nanomoles per liter, while men have levels that can be dozens or even hundreds of times higher - typically 7.7 to 29.4. (nbclosangeles.com)
  • Gynecomastia can occur when there is an imbalance of testosterone and estrogen in the body. (healthline.com)
  • Lifting heavy weights in the gym two or three times a week will help boost testosterone levels and maintain low levels of estrogen and prolactin. (indiatimes.com)
  • Other studies in lab animals have shown that that estrogen increases airway inflammation and testosterone decreases it, but of course that doesn't mean the same thing is happening in people. (kpbs.org)
  • Animal studies also show that licorice supplementation can reduce testosterone levels. (medicalnewstoday.com)
  • However, scientists caution there isn't enough information to determine the safety of regular testosterone supplementation. (healthline.com)
  • Various methods can be used: patches, gels, Intramuscular testosterone supplementation (delivered through periodic injections), or "pellets" implanted beneath the skin. (rochester.edu)
  • Does testosterone supplementation improve the response to sildenafil (Viagra) in men with erectile dysfunction and low testosterone levels? (aafp.org)
  • Testosterone replacement led to a reversal of several lung inflammatory/profibrotic endpoints noted earlier in castrated male CIA + LPS-treated mice with testosterone supplementation promoting neutrophil influx, MAA expression, and TNF-a, IL-6, and MMP-9. (cdc.gov)
  • When City traders have high morning testosterone levels they make more than average profits for the rest of that day, researchers at the University of Cambridge have discovered. (cam.ac.uk)
  • Androgenic anabolic steroid indicated for testosterone replacement. (medscape.com)
  • The American Urology Association (AUA) considers low blood testosterone to be less than 300 nanograms per deciliter (ng/dL) for adults. (clevelandclinic.org)
  • These drugs shut down the production of natural testosterone. (everydayhealth.com)
  • Could it be best natural testosterone supplements in the Yuri Latson, the entire Tami Pepper clan disappeared and was recruited by Dr. Su for a nest? (jewishledger.com)
  • Increased diabetes risk has been connected to higher levels of testosterone to prostate enlargement, a new study reports. (sciencedaily.com)
  • Rock music was be the musical choice of men with higher levels of testosterone. (newsweek.com)
  • When it comes to inappropriate higher levels of testosterone, there are underlying conditions that need to be ruled out,' says Dr. Lucille. (everydayhealth.com)
  • During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). (nih.gov)
  • We also know testosterone and androgens are involved because of studies showing that eunuchs and people who don't have testes have very low rates of BPH," Trumble added. (sciencedaily.com)
  • This is a condition in which the body doesn't produce enough testosterone. (healthline.com)
  • You may notice an increase in your libido soon after starting testosterone replacement therapy. (medicinenet.com)
  • Also, obesity reduces levels of sex hormone binding globulin (SHBG), a protein that carries testosterone in the blood . (webmd.com)
  • Most of the testosterone in the blood attaches to 2 proteins: albumin and sex hormone binding globulin (SHBG). (rochester.edu)
  • Most of the circulating testosterone is bound to carrier proteins (SHBG = sex hormone-binding globulin). (cdc.gov)
  • Sex hormone-binding globulin (SHBG) is the blood transport protein for testosterone and estradiol. (cdc.gov)
  • SHBG has a high binding affinity to dihydrotestosterone (DHT), medium affinity to testosterone and estradiol, and only a low affinity to estrone, DHEA, androstendione, and estriol. (cdc.gov)
  • Testosterone supplements in men with low testosterone also can slightly reduce obesity. (rxlist.com)
  • According to the researchers, this has important implications for the millions of men who use testosterone supplements to counteract low testosterone. (sciencedaily.com)
  • But there's probably a reason your body is producing less testosterone than it used to, and if you try to trick it and flood it with testosterone supplements, you may see some beneficial effects -- people report feeling more energized, having a stronger libido -- but at what cost? (sciencedaily.com)
  • Because of that, it is against the rules for athletes to use testosterone supplements. (nbclosangeles.com)
  • However, testosterone therapy increases the risk of heart disease, so it is not used to treat metabolic syndrome. (webmd.com)
  • What Does Testosterone Replacement Therapy Do? (medicinenet.com)
  • Testosterone replacement therapy (TRT) is mainly used to treat low testosterone levels caused by a medical condition or aging . (medicinenet.com)
  • What are the benefits of testosterone replacement therapy? (medicinenet.com)
  • What are the potential effects of testosterone replacement therapy? (medicinenet.com)
  • The following alternative methods may help increase your testosterone level without the use of hormone therapy. (healthline.com)
  • A more definitive answer for cardiovascular safety of testosterone therapy will come from the TRAVERSE dedicated cardiovascular outcome trial , sponsored by AbbVie, which will have up to 5 years of follow-up, with results expected later this year. (medscape.com)
  • Certainly, great caution is advised regarding the use of testosterone replacement therapy in people with established atherosclerosis due to the findings of plaque progression in the testosterone trials and the excess cardiovascular events observed in the TOM trial, write Michos and fellow editorialist Matthew J. Budoff, MD, of UCLA, in their editorial. (medscape.com)
  • When no specific cause can be identified, testosterone replacement therapy is the most common treatment. (rochester.edu)
  • HAMBURG - Testosterone replacement therapy was associated with significant reductions in A1c at 1 and 2 years among men with type 2 diabetes, a multinational audit shows. (medscape.com)
  • Jones also urges clinicians worldwide to enter their patients' data into the ABCD Testosterone Audit , which aims to identify long-term outcomes and predictors of response to testosterone replacement therapy. (medscape.com)
  • However, both Jones and Anawalt emphasized that testosterone therapy would not be expected to affect blood glucose levels or any other cardiometabolic parameters in men who are not testosterone deficient, regardless of diabetes status. (medscape.com)
  • However, research is inconclusive on whether testosterone replacement therapy can successfully treat erectile dysfunction . (healthline.com)
  • What the majority of doctors (those dabbling in hormone therapy) do not understand is that there is always a reason for low testosterone levels and one must investigate by laboratory and intensive history to find the potential cause(s)," he says. (askmen.com)
  • When Donwell Mpofu started using testosterone for hormone replacement therapy last year, he began feeling comfortable in himself and his body for the first time in his life. (timeslive.co.za)
  • Accessing testosterone and hormone replacement therapy has been a life and gender-reaffirming experience for Mpofu. (timeslive.co.za)
  • The source of Mpofu's anxiety is the current shortage of Pfizer's depo-testosterone, the hormone replacement therapy many transgender people use to transition and then maintain their testosterone levels. (timeslive.co.za)
  • It's treatable with testosterone replacement therapy. (clevelandclinic.org)
  • New York, NY (PRWEB) March 25, 2015 -- A new analysis suggests that prescription low testosterone therapy ( http://www.testosteronelawsuithub.com/ ) is frequently prescribed for men who have no medical need for such treatment. (prweb.com)
  • Only about 73 percent actually had their hormone levels tested before being prescribed testosterone therapy, while just over half had levels tested during the first year of treatment. (prweb.com)
  • The study's conclusions also echo concerns recently put forth by the FDA, which has been reviewing the cardiovascular side effects associated with low T therapy, regarding the extensive use of these medications to relieve low testosterone normally associated with aging," says Sandy A. Liebhard, a partner at Bernstein Liebhard LLP, a nationwide law firm representing victims of defective drugs and medical devices. (prweb.com)
  • The Firm is offering free legal reviews to men who allegedly experienced heart attacks, strokes and other cardiovascular problems due to their use of testosterone replacement therapy. (prweb.com)
  • The FDA has been investigating the safety of low testosterone therapy since January 31, 2014, when it issued an alert detailing two studies which suggested the treatments might increase the risk for heart attack, stroke, and death in certain men. (prweb.com)
  • Although rare, high testosterone levels could be caused by medical conditions or testosterone replacement therapy. (everydayhealth.com)
  • A common cause of excess testosterone is actually testosterone replacement therapy. (everydayhealth.com)
  • By far the most common cause of excess testosterone is testosterone replacement therapy ,' Drincic says. (everydayhealth.com)
  • One way to avoid excess testosterone is to avoid testosterone replacement therapy unless you really need it. (everydayhealth.com)
  • What Is Testosterone Replacement Therapy? (everydayhealth.com)
  • He tried his best to testosterone therapy penis growth a smile I'm sorry Doctor Su, CVS Cialis 20 mg price it's back This question, I think so. (jewishledger.com)
  • Not to mention ripping off the fur and taking it back to sell for money, he couldn't even testosterone therapy penis growth he could only pick out a few dead ice wolves that were male size enhancement let testosterone booster xellerate some experience. (jewishledger.com)
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  • This is unlikely, and there are only two Tushan foxes in testosterone therapy penis growth and Randy Haslett looked at each other, and both felt that this guess was testosterone boosters Walgreens and unbelievable. (jewishledger.com)
  • Concerns over heart attack and blood clot side effects of testosterone therapy previously resulted in thousands of lawsuits against drug manufacturers. (aboutlawsuits.com)
  • This summary information comes from Fass for Testogel (testosterone) company Laboratoires Besins and Tostrex (testosterone) Kyowa Kirin AB with reference to the company Bayer for Androgel (testosterone). (janusinfo.se)
  • Researchers are unlocking the mysteries of how low testosterone is related to men's overall health. (webmd.com)
  • While past studies have shown that men's testosterone levels differentially change in response to winning or losing an interpersonal dominance contest, the present study provides novel evidence showing that vicarious victory and defeat via democratic elections has similar physiological consequences for male voters as do interpersonal dominance contests. (scienceblogs.com)
  • Testosterone used to treat men's energy and libido is becoming more common, but Kehra also puts women right in the middle of that treatment. (click2houston.com)
  • While this study examined men's behavior in the lab, which might not translate exactly to real-life trading preferences, several previous studies have linked testosterone to financial risk-taking and profits, and a 2008 study of actual traders in London similarly linked testosterone and cortisol to changes in investment behavior. (mentalfloss.com)
  • Inside the village, Georgianna Culton also saw Arden Wiers's group flying over from the sky He hurriedly turned around and went best men's testosterone booster After greeting a few guests who lived in his homestay the best sex enhancement pills straight to his room. (jewishledger.com)
  • Testosterone and dihydrotestosterone (DHT), are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. (centerwatch.com)
  • Testosterone is the principle hormone in humans that produces male secondary sex characteristics ( androgenic ) and is an important hormone in maintaining adequate nitrogen balance, thus aiding in tissue healing and the maintenance of muscle mass (anabolic). (medscape.com)
  • Testosterone promotes the development of the secondary sex characteristics in men and serves to maintain the function of the prostate and seminal vesicles. (cdc.gov)
  • As a study posted in Current Drug Abuse Review notes, heavy drinking or regular drinking over long periods causes a decrease in testosterone in males. (medicalnewstoday.com)
  • But he added that, although handling money led to a decrease in testosterone and risk-taking among highly narcissistic men, they were responding to handling money that did not belong to them. (irishtimes.com)
  • which is why we think we observed a decrease in testosterone and risk-taking among narcissists. (irishtimes.com)
  • If you are one of several men who see a 1% decrease in testosterone production each year, you are probably looking for a solution, such as the best testosterone boosters. (washingtoncitypaper.com)
  • However, there is little evidence that testosterone can be used in otherwise healthy men. (medicinenet.com)
  • The hypothalamus and pituitary gland, located in the brain, produce hormonal signals that ultimately result in the production of testosterone. (rxlist.com)
  • Vegetable oils are high in PUFA as they are carriers of omega-3 and omega-6 fats and aid the production of testosterone. (indiatimes.com)
  • Increased production of testosterone in women can cause virilization (depending on the increase). (cdc.gov)
  • In recent years, researchers have noticed general links between low testosterone and other medical conditions. (webmd.com)
  • Researchers noted that spearmint essential oil reduced testosterone levels in these rats. (medicalnewstoday.com)
  • What the researchers determined was that Republican men showed significant reductions in testosterone after they learned that their candidate had lost the election. (scienceblogs.com)
  • The researchers suggest that perhaps female testosterone is more difficult to record in women and doesn't have the same rapid release that males experience, which may have influenced the results. (scienceblogs.com)
  • The researchers also speculated that if testosterone continued to rise or became chronically elevated, it could begin to have the opposite effect on a trader's profitability by increasing risk-taking to unprofitable levels. (cam.ac.uk)
  • The researchers suggest, however, that rising cortisol levels can reduce appetite for risk: that is, affect a trader's risk taking in the opposite direction to testosterone. (cam.ac.uk)
  • The researchers compared a control group of 30 women who received no treatment with a group of nine healthy women in early menopause (ages 47 to 60) who knowingly received the testosterone spray on their skin. (sciencedaily.com)
  • The researchers did not determine whether testosterone replacement alone is as effective as sildenafil for the treatment of erectile dysfunction. (aafp.org)
  • It's difficult for researchers to estimate how common low testosterone is since different studies have different definitions for low testosterone. (clevelandclinic.org)
  • Higher testosterone levels in males was linked with a preference for a type of music that the researchers labeled as "unsophisticated. (newsweek.com)
  • The researchers believe that the reason they were not able to find a connection between testosterone and musical preference in women was because the sample group was too small. (newsweek.com)
  • As testosterone levels decline with age, the researchers initially generated reference ranges in healthy, nonobese men aged 19 to 39 years, followed by ranges stratified by decade of age. (medscape.com)
  • The researchers calculated that, in healthy, nonobese men aged 19 to 39 years, CDC-standardized testosterone levels were 264 ng/dL for the 2.5th percentile, 303 ng/dL for the 5th percentile, 531 ng/dL for the 50th percentile, 852 ng/dL for the 95th percentile and 916 ng/dL for the 97.5th percentile. (medscape.com)
  • Females with high levels of testosterone may have polycystic ovary syndrome. (rochester.edu)
  • The secretion of testosterone is regulated by luteinizing hormone (LH), and is subject to negative feedback via the pituitary and hypothalamus. (cdc.gov)
  • Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. (nih.gov)
  • In fact, one 2021 review concludes that neither soy nor phytoestrogens have any impact on testosterone levels. (medicalnewstoday.com)
  • July 28, 2021 With the Olympics underway, higher testosterone has often been linked to sporting success, and other kinds of success too. (sciencedaily.com)
  • Testosterone cypionate injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone. (nih.gov)
  • A new study anthropologists suggests that the hormone testosterone -- specifically, an unnatural overabundance thereof -- may be a prime culprit. (sciencedaily.com)
  • This test measures the level of the hormone testosterone in your blood. (rochester.edu)
  • Known as the 'male hormone,' testosterone is produced primarily by the testicles . (everydayhealth.com)
  • Anabolic steroids, which are sometimes abused by athletes and body builders, are synthetic versions of the male hormone testosterone. (everydayhealth.com)
  • Research suggests that some doctors may prescribe testosterone off-label to females to improve libido, but this use has not been approved by the Food and Drug Administration (FDA). (healthline.com)
  • Testosterone plays a key role in your sex drive or libido. (healthline.com)
  • In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. (wikipedia.org)
  • More specifically, the Leydig cells in your testicles make testosterone. (clevelandclinic.org)
  • LH then travels to your gonads (testicles or ovaries) and stimulates the production and release of testosterone. (clevelandclinic.org)
  • There was a short-term interruption to the supply of Pfizer's depo-testosterone in 2019, when the company said it was owing to circumstances outside its control. (timeslive.co.za)
  • Pfizer confirmed that increasing its supply of Covid-19 vaccines has caused a temporary shortage of several of its other medications, including depo-testosterone. (timeslive.co.za)
  • In a separate communique sent to healthcare professionals in SA, a Pfizer representative confirmed that there was a depo-testosterone shortage in the country. (timeslive.co.za)
  • B Camminga, co-founder of the African LGBTQI+ Migration Research Network and a postdoctoral fellow at the African Centre for Migration and Society at the University of the Witwatersrand, said shortages of depo-testosterone like the current one are treated as a shocking issue when in fact they point to larger structural issues in healthcare in SA. (timeslive.co.za)
  • They found that when triclocarban enters a man's bloodstream through his skin, it mimics testosterone, causing his body to ratchet down production of real T in response, say study author Bill Lasley. (onemansblog.com)
  • The tribunal said Pogba had violated anti-doping rules when they found the prohibited substance "non-endogenous testosterone metabolites," adding that the results were "consistent with the exogenous origin of the target compounds. (espn.com)
  • Endogenous testosterone released from the sample by ANS (8-anilino-1-naphthalene sulfonic acid) and norgestrel competes with the added testosterone derivative labeled with ruthenium complex for the binding sites on the biotinylated antibody. (cdc.gov)
  • Nevertheless, previous research with women hasn't demonstrated the same decline in testosterone levels after competitive activities. (scienceblogs.com)
  • Losing weight through exercise can increase testosterone levels. (webmd.com)
  • Does Masturbation Increase Testosterone Levels? (captivsenses.com)
  • In short-term studies, testosterone replacement improved blood sugar levels and obesity in men with low testosterone. (webmd.com)
  • As yet, no studies show that testosterone replacement protects the heart or prevents heart attacks . (webmd.com)
  • There was also no association with prostate cancer, although it's important to monitor prostate-specific antigen in patients for the first year on testosterone replacement, Jones said. (medscape.com)
  • In men, low testosterone levels in the body can be supplemented by hormone replacement with testosterone. (rxlist.com)
  • In the United States there are currently no preparations that are FDA approved for testosterone replacement for women. (rxlist.com)
  • Basically, these guys taking testosterone replacement therapies are entering themselves into an uncontrolled experiment," said Trumble. (sciencedaily.com)
  • SpitzerMBasariaSTravisonTGet alEffect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial. (aafp.org)
  • The study, which was published earlier this month in Public Health Reports, looked at insurance data from 61,474 men 40 years or older treated with testosterone replacement drugs from 2001 to 2010. (prweb.com)
  • Ways to Increase Testosterone NaturallyEffects of low testosterone:An imbalance of testosterone resu. (indiatimes.com)
  • An imbalance of testosterone results in low sex drive, erectile dysfunction, breast enlargement, lack of energy, unhealthy weight gain, hair fall and dry skin in men. (indiatimes.com)
  • Study participants received testosterone or a placebo and then were shown color-tinted faces of men and women. (scientificamerican.com)
  • Intention-to-treat and on-protocol analyses found that the addition of testosterone did not significantly improve erectile function compared with the placebo. (aafp.org)
  • In follow-up trials, 30 young men received either a tablet of hydrocortisone or a placebo before they began a stock investment task, and 36 young men received either a dose of testosterone or a placebo. (mentalfloss.com)
  • Although the term steroid includes all agents derived from this ringed structure, this discussion includes only testosterone and the anabolic-androgenic steroids (AASs). (medscape.com)
  • Testosterone has a dual action and can be described in terms of its androgenic and anabolic capacities. (medscape.com)
  • Well over a thousand different compounds have been synthesized and studied since the 1950s in the hope of producing compounds that have an anabolic or androgenic effect superior to that of testosterone. (medscape.com)
  • Almost since their inception, testosterone and anabolic-androgenic analogues have been used and abused by individuals seeking to augment their anabolic and androgenic potential. (medscape.com)
  • The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)
  • although the role of testosterone is far smaller than that of dihydrotestosterone. (wikipedia.org)
  • In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. (nih.gov)
  • Previous research has shown that testosterone levels in males will decline significantly if the sports team they have identified with fails to achieve victory. (scienceblogs.com)
  • Testosterone levels in males drop as they age. (rochester.edu)
  • The spray dose returned testosterone levels in the blood to those typical of young women of childbearing age, according to Davison. (sciencedaily.com)
  • Testosterone levels were tested two weeks after the start of treatment, and the dose was titrated up or down to achieve normal levels. (aafp.org)
  • Boosting low testosterone levels into the normal range did not further improve the effectiveness of sildenafil in men with erectile dysfunction. (aafp.org)
  • Males with low testosterone may report extreme fatigue and decreased energy. (healthline.com)
  • Testosterone helps produce and strengthen bone, so males with low testosterone, especially older men, may have lower bone volume and be more susceptible to bone fractures. (healthline.com)
  • The FDA currently advises against treating males with low testosterone caused only by aging. (rochester.edu)
  • Testosterone is a steroid hormone which is made in the testes in males and in the ovaries in women (a minimal amount is also made in the adrenal glands). (rxlist.com)
  • A majority of testosterone is produced in the sex organs, with a small amount produced in the adrenal glands. (askmen.com)
  • Testosterone is made in the testes in males, the ovaries in females, and in the adrenal glands. (rochester.edu)
  • Since losing voters reported greater submissiveness, we speculate that losing males, who also experienced testosterone decrements, might have been less motivated to engage in dominance behavior after the election. (scienceblogs.com)
  • I don't know of any studies that link specific male behavior to excess testosterone. (everydayhealth.com)
  • Testosterone, so meaningful to a man's behavior, is the evolutionary force behind everything intrinsically "male. (zrtlab.com)
  • According to the organizational-activational hypothesis, the organizational effects of testosterone during (prenatal) brain development moderate the activational effects of adult testosterone on behavior . (bvsalud.org)
  • Many experts believe testosterone contributes to the higher rates of heart disease and high blood pressure that tend to affect men at younger ages. (webmd.com)
  • Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. (medlineplus.gov)
  • Testosterone also contributes to vitality and well-being. (healthline.com)
  • These findings imply that testosterone contributes to lung and arthritis inflammatory responses following CIA + LPS coexposure, but not to systemic autoantibody responses. (cdc.gov)
  • According to these new rules , athletes have seven days to lower their testosterone levels below 5 nmol/L, the restricted limit as decided by the IAAF in 2018. (refinery29.com)
  • Semenya, who is 28 years old and has won two Olympic gold medals in the 800-meter event, has a health condition that causes her to produce more testosterone than most cisgender women, called hyperandrogenism . (refinery29.com)
  • Due to her high levels of testosterone, Semenya was suspended from competition for eight months in 2009. (refinery29.com)
  • The sports world's highest court ruled Wednesday that Olympic champion Caster Semenya and other female runners like her with unusually high testosterone must take medication to reduce their levels of the male sex hormone if they want to compete in certain events - a landmark decision with far-reaching ramifications for other women's sports. (nbclosangeles.com)
  • LAUSANNE, Switzerland (AP) - Caster Semenya won an interim ruling in her battle against the IAAF and its testosterone regulations when the Swiss supreme court ordered athletics' governing body to suspend the rules on Monday. (ksl.com)
  • The temporary suspension of the rules comes after the 28-year-old Semenya last week filed an appeal to the Swiss supreme court asking for the testosterone limits in female events to be removed completely. (ksl.com)
  • If the testosterone rules stay suspended, Semenya would likely be cleared to run in the 800 for the remainder of the Diamond League and, crucially, be able to defend her title at the world championships in Doha, Qatar, in September. (ksl.com)