Presynaptic Terminals: The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.Nerve Endings: Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.Terminal Repeat Sequences: Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.HIV Long Terminal Repeat: Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.DNA Nucleotidylexotransferase: A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 22.214.171.124.Terminal Care: Medical and nursing care of patients in the terminal stage of an illness.Repetitive Sequences, Nucleic Acid: Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).Neuromuscular Junction: The synapse between a neuron and a muscle.Computer Terminals: Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)Synaptic Vesicles: Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Neurotransmitter Agents: Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Synaptosomes: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.Kinetics: The rate dynamics in chemical or physical systems.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Motor Neurons: Neurons which activate MUSCLE CELLS.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Pituitary Gland, Posterior: Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Motor Endplate: The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Molecular Weight: The sum of the weight of all the atoms in a molecule.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Goldfish: Common name for Carassius auratus, a type of carp (CARPS).Pyridinium CompoundsRecombinant Proteins: Proteins prepared by recombinant DNA technology.Nerve Tissue Proteinsgamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Complement Membrane Attack Complex: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Genes, Viral: The functional hereditary units of VIRUSES.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Dendrites: Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.Neurons, Afferent: Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.Synapsins: A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.DNA Nucleotidyltransferases: Enzymes that catalyze the incorporation of deoxyribonucleotides into a chain of DNA. EC 2.7.7.-.Retroelements: Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. Long terminal repeats (LTRs) similar to those from retroviruses are contained in retrotransposons and retrovirus-like elements. Retroposons, such as LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS do not contain LTRs.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Vesicular Glutamate Transport Protein 2: A vesicular glutamate transporter protein that is predominately expressed in the DIENCEPHALON and lower brainstem regions of the CENTRAL NERVOUS SYSTEM.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Synaptic Membranes: Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.Mice, Inbred C57BLMuscles: Contractile tissue that produces movement in animals.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Rana pipiens: A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Vesicular Glutamate Transport Protein 1: A vesicular glutamate transporter protein that is predominately expressed in TELENCEPHALON of the BRAIN.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Microscopy, Immunoelectron: Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Patch-Clamp Techniques: An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Animals, Newborn: Refers to animals in the period of time just after birth.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Synaptophysin: A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Sequence Deletion: Deletion of sequences of nucleic acids from the genetic material of an individual.Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Retinal Bipolar Cells: INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Viral Proteins: Proteins found in any species of virus.Excitatory Postsynaptic Potentials: Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Astacoidea: A superfamily of various freshwater CRUSTACEA, in the infraorder Astacidea, comprising the crayfish. Common genera include Astacus and Procambarus. Crayfish resemble lobsters, but are usually much smaller.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Terminally Ill: Persons with an incurable or irreversible illness at the end stage that will result in death within a short time. (From O'Leary et al., Lexikon: Dictionary of Health Care Terms, Organizations, and Acronyms for the Era of Reform, 1994, p780)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Receptors, Presynaptic: Neurotransmitter receptors located on or near presynaptic terminals or varicosities. Presynaptic receptors which bind transmitter molecules released by the terminal itself are termed AUTORECEPTORS.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Oxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Protein PrecursorsDopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Axonal Transport: The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Horseradish Peroxidase: An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Mammary Tumor Virus, Mouse: The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.Neurosecretion: The production and release of substances such as NEUROTRANSMITTERS or HORMONES from nerve cells.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Microscopy, Electron, Transmission: Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.DNA, Recombinant: Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.PolysaccharidesAcetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.Gene Products, tat: Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Proviruses: Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.tat Gene Products, Human Immunodeficiency Virus: Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 126.96.36.199.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Quaternary Ammonium Compounds: Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.Chromosome Deletion: Actual loss of portion of a chromosome.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Colubridae: The largest family of snakes, comprising five subfamilies: Colubrinae, Natricinae, Homalopsinae, Lycodontinae, and Xenodontinae. They show a great diversity of eating habits, some eating almost anything, others having a specialized diet. They can be oviparous, ovoviviparous, or viviparous. The majority of North American snakes are colubrines. Among the colubrids are king snakes, water moccasins, water snakes, and garter snakes. Some genera are poisonous. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp321-29)
Slippery slopes in flat countries--a response. (1/1175)In response to the paper by Keown and Jochemsen in which the latest empirical data concerning euthanasia and other end-of-life decisions in the Netherlands is discussed, this paper discusses three points. The use of euthanasia in cases in which palliative care was a viable alternative may be taken as proof of a slippery slope. However, it could also be interpreted as an indication of a shift towards more autonomy-based end-of-life decisions. The cases of non-voluntary euthanasia are a serious problem in the Netherlands and they are only rarely justifiable. However, they do not prove the existence of a slippery slope. Persuading the physician to bring euthanasia cases to the knowledge of the authorities is a problem of any euthanasia policy. The Dutch notification procedure has recently been changed to reduce the underreporting of cases. However, many questions remain. (+info)
Conditions required for a law on active voluntary euthanasia: a survey of nurses' opinions in the Australian Capital Territory. (2/1175)OBJECTIVES: To ascertain which conditions nurses believe should be in a law allowing active voluntary euthanasia (AVE). DESIGN: Survey questionnaire posted to registered nurses (RNs). SETTING: Australian Capital Territory (ACT) at the end of 1996, when active voluntary euthanasia was legal in the Northern Territory. SURVEY SAMPLE: A random sample of 2,000 RNs, representing 54 per cent of the RN population in the ACT. MAIN MEASURES: Two methods were used to look at nurses' opinions. The first involved four vignettes which varied in terms of critical characteristics of each patient who was requesting help to die. The respondents were asked if the law should be changed to allow any of these requests. There was also a checklist of conditions, most of which have commonly been included in Australian proposed laws on AVE. The respondents chose those which they believed should apply in a law on AVE. RESULTS: The response rate was 61%. Support for a change in the law to allow AVE was 38% for a young man with AIDS, 39% for an elderly man with early stage Alzheimer's disease, 44% for a young woman who had become quadriplegic and 71% for a middle-aged woman with metastases from breast cancer. The conditions most strongly supported in any future AVE law were: "second doctor's opinion", "cooling off period", "unbearable protracted suffering", "patient fully informed about illness and treatment" and "terminally ill". There was only minority support for "not suffering from treatable depression", "administer the fatal dose themselves" and "over a certain age". CONCLUSION: Given the lack of support for some conditions included in proposed AVE laws, there needs to be further debate about the conditions required in any future AVE bills. (+info)
Use of resources and costs of palliative care with parenteral fluids and analgesics in the home setting for patients with end-stage cancer. (3/1175)BACKGROUND: In 1992 a home care technology project was started in which infusion therapy in the home setting was made available for patients with end-stage cancer. Beside aspects of feasibility and quality of life the resource utilization and costs of this transition was studied. PATIENTS AND METHODS: We conducted a cost evaluation study, to determine the actual cost of managing patients with endstage cancer who require parenteral administration of fluid or analgesics in the home setting. A total of 128 patients were prospectively followed, with a detailed analysis of some aspects in a sample of 24 patients. RESULTS: The cost for each patient was found to be between $250.00 and $300.00 per day, half of which are for hospital charges, even with this active home care technology program. One-third of the costs can be attributed to primary health care activities, in particular those of the district nurses. A hypothetical control group (n = 25) was constructed based on current practice and chart review. Patients in this group would have cost around $750.00 per day. With a median treatment period of 16 days this means a saving of $8000.00 per patient. CONCLUSION: Our data suggest that significant savings can be obtained by implementing programs transferring palliative care technology to the home setting. (+info)
The timing of do-not-resuscitate orders and hospital costs. (4/1175)The relation between the timing of do-not-resuscitate (DNR) orders and the cost of medical care is not well understood. This prospective observational study compares hospital costs and length of stay of 265 terminally ill patients with admission DNR orders, delayed DNR orders (occurring after 24 hours), or no DNR orders (full code). Patients whose orders remained full code throughout a hospital stay had similar lengths of stay, total hospital costs, and daily costs as patients with admission DNR orders. Patients with delayed DNR orders, by contrast, had a greater mortality, longer length of stay, and higher total costs than full code or admission DNR patients, but similar daily costs. The causes of delay in DNR orders and the associated higher costs are a matter for future research. (+info)
Do social factors affect where patients die: an analysis of 10 years of cancer deaths in England. (5/1175)BACKGROUND: This study investigated whether indices of social deprivation were related to the proportion of cancer patients who died at home. METHODS: Data were derived from death registrations for all cancer deaths 1985-1994 in England. Two indices of deprivation (Underprivileged Area Score (UPA), or Jarman, and Townsend scores) were calculated for each electoral ward; 1991 Census data were used. The scores use combinations of variables, including the percentage in overcrowded homes, the percentage of elderly people living alone, the percentage of one-parent families, etc. A high score indicates more deprivation. The main outcome measures were the proportion (in five and ten year averages) of cancer deaths which occurred at home, calculated for every electoral ward (with populations usually ranging from 5000 to 11,000). Spearman rho was used to test for correlations between the proportion of cancer deaths at home and deprivation score. Electoral wards were categorized by deprivation score into three groups of equal size and analysed over 10 years. Multivariate analysis was used to determine the relative association of different patient based and electoral ward variables with cancer death at home. p < 0.05 (two-tailed) was taken as significant. RESULTS: There were over 1.3 million death registrations from cancer in the 10 years. The proportion who died at home was 0.27, in hospital 0.47, and other setting 0.26. There were wide variations (0.05-0.75) in the proportion of people who died at home in different electoral wards. Small inverse correlations were found between the percentage who died at home and the UPA (-0.35; p < 0.001) and Townsend (-0.26; p < 0.001) scores. The correlations were greatest in North Thames (-0.63, UPA) and smallest in West Midlands (-0.20, UPA). The proportion of home deaths for the different bands of deprivation were: 0.30 (low deprivation), 0.27 (middle deprivation) and 0.24 (high deprivation). Plotting the trends over 10 years suggests no change in this relationship. Multiple regression analysis predicted several ward and patient characteristics and accounted for 30 per cent of the variation. Increased age (patient variable), Jarman score and ethnic minorities (both ward variables) were associated with fewer patients dying at home. Being male and having cancer of the digestive organs were associated with home death. CONCLUSION: There are wide variations in the percentage of cancer deaths at home in different electoral wards. Social factors are inversely correlated with home cancer death, and may explain part of this variation. Home care in deprived areas may be especially difficult to achieve. (+info)
Abandonment of terminally ill patients in the Byzantine era. An ancient tradition? (6/1175)Our research on the texts of the Byzantine historians and chroniclers revealed an apparently curious phenomenon, namely, the abandonment of terminally ill emperors by their physicians when the latter realised that they could not offer any further treatment. This attitude tallies with the mentality of the ancient Greek physicians, who even in Hippocratic times thought the treatment and care of the terminally ill to be a challenge to nature and hubris to the gods. Nevertheless, it is a very curious attitude in the light of the concepts of the Christian Byzantine physicians who, according to the doctrines of the Christian religion, should have been imbued with the spirit of philanthropy and love for their fellowmen. The meticulous analysis of three examples of abandonment of Byzantine emperors, and especially that of Alexius I Comnenus, by their physicians reveals that this custom, following ancient pagan ethics, in those times took on a ritualised form without any significant or real content. (+info)
The status of the do-not-resuscitate order in Chinese clinical trial patients in a cancer centre. (7/1175)OBJECTIVE: To report and analyse the pattern of end-of-life decision making for terminal Chinese cancer patients. DESIGN: Retrospective descriptive study. SETTING: A cancer clinical trials unit in a large teaching hospital. PATIENTS: From April 1992 to August 1997, 177 consecutive deaths of cancer clinical trial patients were studied. MAIN MEASUREMENT: Basic demographic data, patient status at the time of signing a DNR consent, or at the moment of returning home to die are documented, and circumstances surrounding these events evaluated. RESULTS: DNR orders were written for 64.4% of patients. Patients in pain (odds ratio 0.45, 95% CI 0.22-0.89), especially if requiring opioid analgesia (odds ratio 0.40, 95% CI 0.21-0.77), were factors associated with a higher probability of such an order. Thirty-five patients were taken home to die, a more likely occurrence if the patient was over 75 years (odds ratio 0.12, 95% CI 0.04-0.34), had children (odds ratio 0.14, 95% CI 0.02-0.79), had Taiwanese as a first language (odds ratio 6.74, 95% CI 3.04-14.93), or was unable to intake orally (odds ratio 2.73, 95% CI 1.26-5.92). CPR was performed in 30 patients, none survived to discharge. CONCLUSIONS: DNR orders are instituted in a large proportion of dying Chinese cancer patients in a cancer centre, however, the order is seldom signed by the patient personally. This study also illustrates that as many as 20% of dying patients are taken home to die, in accordance with local custom. (+info)
Edmonton Regional Palliative Care Program: impact on patterns of terminal cancer care. (8/1175)The Edmonton Regional Palliative Care Program was established in July 1995 to measure the access of patients with terminal cancer to palliative care services, decrease the number of cancer-related deaths in acute care facilities and increase the participation of family physicians in the care of terminally ill patients. In this retrospective study the authors compared the pattern of care and site of deaths before establishment of the program (1992/93) and during its second year of operation (1996/97). Significantly more cancer-related deaths occurred in acute care facilities in 1992/93 than in 1996/97 (86% [1119/1304] v. 49% [633/1279]) (p < or = 0.001). The number of inpatient days decreased, from 24,566 in 1992/93 to 6960 in 1996/97. More cancer patients saw a palliative care consult team in 1996/97 than in 1992/93 (82% v. 22%). The shift from deaths in acute care facilities to palliative hospices suggests that the establishment of an integrated palliative care program has increased access of patients with terminal cancer to palliative care. (+info)
End-of-Life Decision Making | The Royal Society of Canada
End-of-Life Decision Making is an issue wrapped in controversy and contradictions for Canadians. Most people in this country want to die at home, but few do; most believe planning for dying is important and should be started while people are healthy, but almost no one does it. And while most Canadians support the decriminalization of voluntary euthanasia and assisted suicide, both remain illegal under the Criminal Code of Canada. Assisted dying is a critically important public policy issue, where opinion, practice and the law seem out of alignment. The Royal Society of Canada, a national organization of distinguished scholars, artists and scientists, believes the time has come for a national debate on end-of-life decision making. It commissioned us, a panel of six Canadian and international experts on bioethics, clinical medicine, health law and policy, and philosophy, to prepare this report-both to trigger a national conversation on end-of-life issues and contribute material for those ...
New Study Looks at End-of-life Decision-making for People with Intellectual Disabilities
HealthNewsDigest.com) - BUFFALO, N.Y. - A new study by researchers at the University at Buffalo provides a groundbreaking look at how advance care planning medical orders inform emergency medical service (EMS) providers experiences involving people with intellectual disabilities.. Most states in the U.S. have programs that allow terminally ill patients to document their end-of-life decisions. In New York, the Medical Orders for Life-Sustaining Treatment form (MOLST) allows individuals to document what measures health care providers, including EMS providers, should take near the end of a patients life.. Studies suggest that this approach to person-centered advance care planning can alleviate a dying patients pain and suffering, according Deborah Waldrop, a professor in the UB School of Social Work and an expert on end-of-life care. Yet little research on end-of-life decision-making has been done on the growing population of older Americans with intellectual disabilities, which the American ...
End-of-life Decision-Making for People with Intellectual Disabilities
A 2017 study by researchers at the University at Buffalo and published in the Journal of Applied Research in Intellectual Disabilities provides a groundbreaking look at how advance care planning medical orders inform emergency medical service (EMS) providers experiences involving people with intellectual disabilities.. A release from the university explains that most states in the U.S. have programs that allow terminally ill patients to document their end-of-life decisions. In New York, the Medical Orders for Life-Sustaining Treatment form (MOLST) allows individuals to document what measures health care providers, including EMS providers, should take near the end of a patients life.. Studies suggest that this approach to person-centered advance care planning can alleviate a dying patients pain and suffering, according Deborah Waldrop, a professor in the UB School of Social Work and an expert on end-of-life care. Yet little research on end-of-life decision-making has been done on the growing ...
Resource use, costs and quality of end-of-life care: observations in a cohort of elderly Australian cancer decedents |...
Cancer care imposes a significant burden on health systems globally with the year following diagnosis and last year of life being the most resource-intensive stages of care . Relative to the evidence-base supporting clinical decision-making at the time of a cancer diagnosis, there is limited understanding about what constitutes quality end-of-life care [2-5]. Randomized trials of end-of-life treatments and services remain rare and likely to remain so for ethical and practical reasons [6-9]. Therefore, researchers need to utilize other methods and data to examine this important area of medical practice. Observational research on end-of-life care can enhance our understanding of patterns of care in real-world clinical settings and assist in establishing evidence to inform clinical practice, resource allocation and planning decisions.. Observational studies using linked health administrative datasets to explore patterns of end-of-life care have increased in recent years. The use of existing data ...
M28 Respiratory Clinicians' Experiences of End-of-Life Care in Idiopathic Pulmonary Fibrosis | Thorax
Results 57 completed questionnaires - 17 chest consultants, 28 chest registrars, 11 physiotherapists, and 1 nurse clinician. 23 (40%) initiated End-of-Life discussions in severe IPF frequently or very frequently, and 47 (84%) felt it was a very important or important part of their role, but 42% felt predicting prognosis in advanced IPF was difficult or very difficult. More consultants felt End-of-Life discussions were an important part of their role than registrars.. Several aspects of End-of-Life care were felt to be harder in severe IPF than advanced malignancy (Figure 1), although similar to advanced COPD. 22 (42%) referred patients with severe IPF to hospital palliative care services very frequently or frequently, and 19 (37%) to community palliative care very frequently or frequently. Less than 10% of all respondents felt they had significant training in initiating End-of-Life discussions, palliating symptoms, or services available. ...
Initial development and psychometric testing of an instrument to measure the quality of children's end-of-life care | BMC...
The field of pediatric palliative care is hindered by the lack of a well-defined, reliable, and valid method for measuring the quality of end-of-life care. The study purpose was to develop and test an instrument to measure mothers perspectives on the quality of care received before, at the time of, and following a childs death. In Phase 1, key components of quality end-of-life care for children were synthesized through a comprehensive review of research literature. These key components were validated in Phase 2 and then extended through focus groups with bereaved parents. In Phase 3, items were developed to assess structures, processes, and outcomes of quality end-of-life care then tested for content and face validity with health professionals. Cognitive testing was conducted through interviews with bereaved parents. In Phase 4, bereaved mothers were recruited through 10 childrens hospitals/hospices in Canada to complete the instrument, and psychometric testing was conducted. Following review of 67
Transfusion dependence a barrier to quality end-of-life care for some with leukemia | EurekAlert! Science News
For patients with advanced leukemia, access to high-quality end-of-life care appears to be reduced in those dependent on blood transfusions, according to a new study being presented during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta. The study associates this reduced access and consequent diminished use of hospice services with a reduced quality of end-of-life care for these patients.
UPMC and Beckwith Institute Join National Effort to Help Health Care Providers Honor Patients' Wishes for End-of-Life Care
Roundtable Prepares Agenda for Conference on African-American Perspectives on End-of-Life Care - RWJF
CMPA - Providing quality end-of-life care
On June 17, 2016, amendments to the Criminal Code came into force rendering medical assistance in dying (MAID) legal everywhere in Canada provided certain conditions are met.2 The Criminal Code now provides an exception to the criminal prohibition against assistance in dying for individuals who are eligible for health services funded by a government in Canada, who are at least 18 years of age and capable of making decisions about their health, have a grievous and irremediable medical condition, have made a voluntary request for MAID, and who provide informed consent. Individuals have a "grievous and irremediable medical condition" if they have a serious and incurable illness, disease or disability, are in an advanced state of irreversible decline in capability, and if their condition causes them enduring physical or psychological suffering that is intolerable to them and that cannot be relieved under conditions they consider acceptable. In addition, the medical condition must be such that the ...
Potential for response bias in family surveys about end-of-life care in the ICU<...
TY - JOUR. T1 - Potential for response bias in family surveys about end-of-life care in the ICU. AU - Kross, Erin K.. AU - Engelberg, Ruth A.. AU - Shannon, Sarah E.. AU - Curtis, J. Randall. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Background: After-death surveys are an important source of information about the quality of end-of-life care, but response rates generally are low. Our goal was to understand the potential for nonresponse bias in survey studies of family members after a patients death in the hospital ICU by identifying differences in patient demographics and delivery of palliative care between patients whose families respond to a survey about end-of-life care and those whose families do not. Methods: We performed a cohort study of patients who died in the ICU at 14 hospitals. Surveys were mailed to family members 1 to 2 months after the patients death. Chart abstraction was completed on all patients, assessing demographic characteristics and previously validated indicators of ...
Have your views on end-of-life medical treatment changed? | 89.3 KPCC
The conversation around how to deal with a late-stage illness is changing in the United States. According to new data from the Pew Research Center, a growing number of people in the United States are choosing to be significantly more aggressive in treating end-of-life illnesses. In fact, the study reports that the number of respondents who say a doctor should always do everything possible to save a life has doubled from 15 to 31 percent since 1990. Some 35 percent of adults said they would instruct their doctors to keep them alive, even if they were in significant pain or battling a disease with little chance of recovery. How, if at all, have your views changed? Why?. Everything you share will be read by journalists only, and your responses are confidential unless you tell us we may publish them.. ...
Families stall end of life talks, say doctors. True? | COPD PRAXIS
The author cites a recent JAMA Internal Medicine article on physician- and nursing- reported barriers to end-of-life decision making. The study found that surveyed clinicians identified patient and caregiver reluctance to discuss as well as patient and caregiver lack of understanding of these issues as their primary obstacles to successful discussion of end-of-life issues in an ICU setting; however...
Unrealistic Patient Expectations Top Barrier to Quality EOL Care - ONA
Patients get more aggressive end-of-life interventions when physicians take over decision-making, study finds | FierceHealthcare
End-of-Life Talks Key for HF Patients | Medpage Today
Publications | Page 2 | End-of-Life Care Research Group
End-of-Life Care Depends on Doctor - Drugs.com MedNews
August 2019 - meritalarm xyz
Additional qualification in professional pedagogics: practical cialis patent expiration mentoring is no minor matter To characterize how ICU physicians approach and manage conflict with surrogates regarding end-of-life decision-making. Age dependent regulation of bone-mass and renal function by the MEPE cialis generic ...
Increasing the number of patients receiving information about transition to end-of-life care : the effect of a half-day...
Introduction: Honest prognostication and information for patients are important parts of end-of-life care. This study examined whether an educational intervention could increase the proportion of patients who received information about the transition to end-of-life (ITEOL care).. Method: Two municipalities (in charge of nursing homes) and two hospitals were randomised to receive an interactive half-day course about ITEOL for physicians and nurses. The proportion of patients who received ITEOL was measured with data from the Swedish Register of Palliative Care (SRPC). Patients were only included if they died an expected death and maintained their ability to express their will until days or hours before their death. Four hospitals and four municipalities were assigned controls, matched by hospital size, population and proportion of patients receiving ITEOL at baseline.. Results: The proportion of patients in the intervention group who received ITEOL increased from 35.1% (during a 6-month period ...
Experiences, Dreams, and Visions: Easing the Patient With Cancer Toward End of Life - ONA
First culturally based end-of-life care protocol created by community members published - News | UAB
What's getting you through your last weeks of work? - September 2017 - BabyCenter Australia
Whats getting you through your last weeks of work?: Whats getting you through your last weeks of work? Im interested in all ideas.. emotion, goal setting, intrinsic rewards, etc. (N.B. you can stop reading here & comment if you dont want to read about me feeling sorry for myself) Im 31+1, with twins, 2nd pregnancy. Annnd Im done! I never said ...
my period has been irregular for the last month am worried because i been under stress too in my last period only last for ah...
pains: I upped my NDT last week from 1 3/4 Mon... - Thyroid UK
All the best hardware and app reviews last week on TUAW
My son (4.5 years) breaks out in these spots. He has since he was 1. They seem to last weeks each time he breaks out.
How to Start Your End-of-Life 'Conversation' - ABC News
New end-of-life care rules are 'worse than the death pathway' | Daily Mail Online
Question for May 10th | SparkPeople
HPC as a Service: Lessons Learned
|img style=float: left; src=http://media2.hpcwire.com/hpcwire/CFD_Flow_small.bmp alt= width=94 height=84 /|After a fast-paced three months, round 1 of the HPC Experiment (also known as the Uber-Cloud Experiment) concluded last month, with more than 160 participating organizations and individuals from 25 countries, working together in 25 international teams. In this article we present their main findings, challenges, and their lessons learned.
Polkadot Mixtape | April 2010 - Polkadot
Cataloguing Cullaloe: June 2014
Some records are yet to be added from vouchers which have been taken, and all are subject to review, but here it is - The Cullaloe 500 of 2014! I had hoped to complete this number by the end of the year, so who knows how it will end now. I will undoubtedly focus on groups that I have more of a direct interest in, and perhaps spend less time chasing than I have in the last month ...
What I Learned from my Whole 30 - La Vie En C.Rose
Flu Still Widespread but Easing in Some States: CDC - Drugs.com MedNews
You remember how I was bitten with the organizing-reorganizing-redecorating-crafting bug last month? New lamp bases were my first thought but second to last on follow through (art in the bedroom is still pending). As youll see, there was nothing wrong with the lamps before. I was growing a little tired of black bases and a…
depressed after a month long flare | DailyStrength
My dad | DailyStrength
Wish they had an answer!!! | Netmums
Lenovo makes $100 'goodwill' offer after cancelling orders due to pricing error | CTV News
Don't Get Sunburned! But if You Do... | Allure
Next visit in 4 weeks? - PurseForum
Decoding the 'Flame' virus - CNN
Capacity Planner: Not enough Data? |VMware Communities
Everyday I am studying
The Fix - FixCam: Debate Night! (And the Return of Twittering)
Hospice of Washington County | Quality end-of-life care and grief support experts
End-of-life Decision-making in Patients With Sepsis-related Organ Failure - No Study Results Posted - ClinicalTrials.gov
End-of-life discussions must go beyond medical preferences, Letters in Print News & Top Stories - The Straits Times
Resources for living with terminal cancer - Facing Cancer with Grace
Symptoms of terminal cancer - Answers on HealthTap
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Ho on symptoms of terminal cancer: Pancreas is a fish-shaped organ with its head tucked into the duodenum (c-shaped beginning of small intestine coming off stomach). If tumor blocks bile duct or panc duct, causes abdominal pain, pancreatitis, jaundice. If its in tail, will cause no symtptoms till very large or spread to other areas. Most common: weight loss, mental status change such as new onset depression. for topic: Symptoms Of Terminal Cancer
AIDS Treatment News: January 2011
Democracy Now: "DR. ATUL GAWANDE: Well, this change, which is to remove provisions that would have allowed for doctors to have additional payments to have end-of-life discussions with their patients, is an example of the mistake that repeal represents as a whole. End-of-life discussions are not death panels. But you say it over and over again, you brand it over and over again, and you begin to define what the meaning is of a major policy thats passed. Being able to provide funding for discussions that have been shown to have a huge difference in improving the quality of life patients have and, in a recent study published in the New England Journal, also generated longer life for patients by helping them make better decisions about when to stop therapies that have become harmful to them, like that fourth round of chemotherapy and so on, those kinds of studies indicate we need more, longer and better discussions with doctors, overall. Repeal is a major mistake. Our choices are stalemate on making ...
Mandela situation sparks end-of-life discussions - StarTribune.com
another cancer - End-of-life issues - Prostate Cancer UK Online Community
Final Words: Medicare End-of-Life Counseling Coverage
By Kathryn Brown, DePaul University College of Law. Medicare recently announced that starting in 2016 advanced care planning will be covered including discussions that physicians have with their patients regarding the kind of care the patient wants to receive at the end of life. Advanced-care planning, also known as end-of-life counseling, may be legal, medical, practical, psychological, or spiritual in nature. It involves discussing the choices about what kind of help a person will want and need, as well as whether to receive care at home or in an institutional setting. End-of-life counseling often includes making legal decision about wills, advanced directives, and durable powers of attorney. These conversations are vital because a "good death" can have different meanings for different people. Patients commonly hope to have their end-of-life wishes followed, whatever they are, and being treated with respect while dying are common hopes.. While drafting the Affordable Care Act legislation, ...
Articles about Terminal Illness - tribunedigital-dailypress
Parental Perspectives on End-of-Life Care in the Pediatric Intensive Care Unit
Catholic Directive May Thwart End-Of-Life Wishes : NPR
The January 26 post below ("How to Rein in Medicare costs without Hurting Seniors") has drawn some 43 comments (including mine, as I responded to readers). I thought of turning a couple of my replies into posts, but then decided it might be more interesting for you to read them in the context of what other readers said.. I would love to see more readers participate in this thread. Comments are still open.. Its a lively thread that takes on a number of third-rail issues: Does Medicare spend too much on pricey cancer drugs, end-of-life care and brand name hospitals?. Should we try to spend less on end-of life care? Many say "Yes," but Zeke Emanuel (a medical ethicist and oncologist who was part of the Obama team during the presidents first term), says "No." I link to a column where he notes that "It is conventional wisdom that end-of-life care is an increasingly huge proportion of health care spending. . . Wrong. Here are the real numbers: end-of-life care (not just for the elderly, but for all ...
Outgoing AIG CEO given terminal cancer diagnosis - Aug. 28, 2014
Living with a terminal illness
Sources used | Living with a terminal illness
A Shared Care Approach for Seriously Ill Cancer Patients Between General Practice, Discharge Department and a Specialist...
بازنگری این صفحه
DUKE NUS - Vital Science - Research - More news
Cancer | Strand Books
Pass (thoracic oncology, New York U. Langone Medical Center) et al. answer questions patients, survivors, friends, and families of those with mesothelioma might have about the condition. They address what it is, its causes, risk factors, and prevention; diagnosis, symptoms, and finding doctors; psychosocial support, talking to family and children, and insurance and financial concerns; legal implications and rights; treatment, staging, survival rates, and palliative care; clinical trials, experimental and investigational treatments, and treatment plans; side effects of therapy, pain, and diet and exercise suggestions; recurrence; and caregiving and end-of-life issues. This edition has been updated to provide the doctors and patients views; it includes two authors whose family members have the disease. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com ...
Population and Aging | RAND
RAND research on population and aging analyzes demographic and immigration trends and explores a range of issues, from family planning to religion to discrimination. RAND also studies vulnerable populations--such as the elderly and the poor--analyzing retirement and other aspects of financial decisionmaking, welfare, and end-of-life issues.
Preempting End-of-Life Decisions | Medpage Today
As someone who travels frequently for work and lives a distance from my relatives, its important to me to make sure strangers arent making one of the biggest decisions of my life -- under what circumstances I would want to live when all hope seems lost. I already carry a simpler copy in my wallet in case of an emergency to make sure my wishes are known ...
Cultural differences complicate a terminal cancer diagnosis | ACP Internist
NINR Director Discusses NINR's End-of-Life and Palliative Care Work | National Institute of Nursing Research
Advance Care Planning in End of Life Care - Oxford Scholarship
Advance Care Planning is an essential part of the new NHS National Programme on End-of-Life Care, aiming to improve the chances of a good death by discussing and planning how this might be managed. This book helps readers explore a wide range of issues and practicalities in providing Advance Care Planning (ACP) for their patients nearing the end of life. This book takes a comprehensive look at the subject of ACP; frames the purpose, process, and outcomes; and includes contributions from experts from around the world.
Police to probe four death pathway cases at same hospital | Daily Mail Online
End-of-Life Doula Training | New Jersey Health Care Quality Institute
Abortion as end-of-life care: Why I chose a peaceful life and death for my son.
Promoting Excellence in End-of-Life Care - RWJF
The effectiveness of the Liverpool care pathway in improving end of life care for dying cancer patients in hospital. A cluster...
Despite the development of palliative care services worldwide  and numerous studies showing that most cancer patients would prefer to die at home [2, 3], most cancer patients still die in hospital [3, 4]. Official Italian statistics on place of death are not available for Italy, but according to ISDOC survey , it is estimated that one third (34.6%) of cancer patients die in hospital, with broad geographical differences (from 60.2% in the North East to 4.6% in the South and islands). According to the ISDOC survey it is also possible to estimate that about 50% of all hospital cancer deaths occur on medical wards .. A number of studies carried out in different countries [5-8] have shown the poor quality of end-of-life care delivery in hospitals. Inappropriate end-of-life care may result in the continuation of invasive treatments that, in addition to having negative consequences in terms of resource management, negatively impact the quality of life of patients [9, 10]. The results of two ...
'Saddest but most moving thing': Terminally ill cancer patient marries longtime partner at...
Why didn't I have my normal period last month? - Menstrual Cycle Question
I want to conceive. I had a depo last week - Doctor's insight on HealthcareMagic
Last week was all about getting ready for workshop with @thebejkr1 who Recipe - Royalgram
Art of Oscar Rosales: #inktober Day 26 - This is it, we're in the last week of...
I had a ultra sound last week and the could only see the sac and no fetal pole. | Mom Answers | BabyCenter
I have a lazy eye since birth, but I could see pretty well and it has not changed vision in 53 years. In the last week
FML : Today, I am still coughing. I was diagnosed with whooping cough last week, which apparently cannot be treated....
United against cancer: prevention to end-of-life care-highlights from the Uganda Cancer Institute-Palliative Care Association...
United against cancer: prevention to end-of-life care-highlights from the Uganda Cancer Institute-Palliative Care Association...
Using Patient-Reported Distress to Guide the Timing of Palliative Care Conversations
Aeiforos SA uses Sesotec sorter for ELV metal recovery in Thessaloniki | Recyclingportal
What Determines End-of-Life Assets? A Retrospective View | NBER
End-of-Life Care in the Intensive Care Unit: A Research Agenda
The Tyler Project: Fiero Enthusiasts Rebuild Car for Teen with Cancer | Gimundo: The Brighter Side
Courageous Leeds doctor is youngest for top medical award - Yorkshire Evening Post
About.com Palliative Care: What's Hot Now comments 230657 Feedage.com
Hi I have fungus infection from Last month I have treated by MD Dr. but not getting bat...
Palliative care should be embraced, not feared
Library of Congress Classification:Class R -- Medicine
Terminal care. Dying R727-727.5 Medical personnel and the public. Physician and the public R728-733 Practice of medicine. ... Economics of medical care. Employment RA411-415 Provisions for personal medical care. Medical care plans RA418-418.5 Medicine ... Critical care. Intensive care. First aid RC91-103 Disease due to physical and chemical agents RC109-216 Infectious and ... Operative obstetrics RG801-871 Puerperal state RG940-991 Maternal care. Prenatal care services RJ47.3-47.4 Genetic aspects RJ50 ...
List of California ballot propositions 1990-99
151 - Failed - Child Care Facilities Financing Act Of 1990. 152 - Passed - School Facilities Bond Act of 1992 153 - Passed - ... Terminal Condition. 162 - Passed - Public Employees' Retirement Systems. 163 - Passed - Ends Taxation of Certain Food Products ... 214 - Failed - Health Care. Consumer Protection. Initiative Statute. 215 - Passed - Compassionate Use Act of 1996. Medical Use ... 216 - Failed - Health Care. Consumer Protection. Taxes on Corporate Restructuring. 217 - Failed - Top Income Tax Brackets. ...
In medicine, specifically in end-of-life care, palliative sedation (also known as terminal sedation, continuous deep sedation, ... "Terminal Sedation", The World Federation of Right to Die Societies. *Discussion Forum, European Association for Palliative Care ... A Living Will, made when competent, can, under UK law, give a directive that the patient refuses 'Palliative Care' or 'Terminal ... On the other hand, a 2009 survey of almost 4000 U.K. patients whose care had followed the Liverpool Care Pathway for the dying ...
Scottish National Entitlement Card
Main cardholder lives in a care or residential home and receive the higher or middle rate of the care component Disability ... Having a terminal illness. Having a progressive degenerative condition. Having lost one or more limbs. Being an injured veteran ... Living in a care or residential home or hospital. Being a Blue Badge holder. Being profoundly or severely deaf. Having a visual ... Having a mental illness, learning difficulty or personality disorder recognised under the Mental Health (Care and Treatment) ( ...
Edington Cottage Hospital
The negative battery terminal is connected to the car's chassis.. The Hudson Motor Car Company was the first to use a ... "The Automotive Storage Battery Its Care and Repair". PowerStream. Archived from the original on April 4, 2016. ... Corrosion at the battery terminals can prevent a car from starting due to electrical resistance, which can be prevented by the ... Physical format: batteries are grouped by physical size, type and placement of the terminals, and mounting style. ...
Morality for Beautiful Girls
She is caring for one of her brothers, dying from disease. She is in her twenties. She has been given the title of assistant ... He is very ill, with a terminal illness. Mma Silvia Potokwane: Matron of the orphan farm outside Gaborone. She is a most ... He is a lively boy, well-behaved like his sister, who has been caring for him since his birth. He and his sister are of the ... She aids in the care of the foster children, and has children of her own. Big Government Man: He seeks the aid of the No. 1 ...
Weldon had his life shortened by "two hours" according to the prosecution when Martin gave him a terminal dose of painkillers. ... caring practitioner." "Dr Shipman used opiate drugs for himself. I am drugs free." "He killed for his own power and ... I merely kept patients asleep when they were in dire circumstances." "Dr Shipman chose patients who were not terminal. I only ...
Sisters (American TV series)
Advancing Cancer Care for Economically Stressed Families (ACCES): ACCES Is a financial aid program in Washington State for low- ... "Sedro-Woolley doctor helping terminal patients in India, Nepal". GoSkagit.com. Retrieved 21 September 2017. "Ujjain: MoU signed ... This program is the first home hospice and palliative care service ever offered in the state with a population of 73 million. ... The goal of this program is to create hospice and palliative care services in Nepali communities where access to healthcare is ...
Intensive care department Chung King-fai as Dom Cheung (張大偉; Cheung Tai-wai) Chief of staff of the Intensive care unit. He ... He later has terminal lung cancer and eventually dies. Hugo Wong as Jason Chow (周景臣; Chow Geng-san) A doctor who sees nurses as ... Andy Lau Tin-lung as Wong Kwok-lap (黃國立) A patient in the intensive care ward. Adam Ip as Wong Dai-hing (王大興) A vomiting ... Elaine Yiu as Sylvia To (杜羨花; To Sin-fa) - female age 35 A nurse in the Intensive Care unit. She was the new intern nurses ...
It's a Wonderful Lie (House)
Maggie is told she has an unknown terminal disease. When it is revealed to Jane that Maggie has a terminal disease, she tells ... House says it's because he doesn't care, and that Jane told her non-biological mother the truth exactly because she cared. The ... In the meantime, Jane goes to the lab to tell the doctors that she does not care what her mother thinks; she wants her bone ...
Life Matters Media
... sometimes accompanied by other end of life care experts, help seniors consider their own end of life care preferences and ... "Reporter, Northwestern Doctor Launch Website About Facing Terminal Illness". CBS Chicago. Retrieved 2015-11-18. "Winning the ... "Advance care planning among seniors of a diverse city". Journal of Clinical Oncology. ISSN 0732-183X. "Death and beer: ... He came into the care of Mulcahy, a medical oncologist at Northwestern Memorial Hospital in Chicago. Though Mulcahy always told ...
Marie Curie Cancer Care Nurses; St John's Ambulance. Hecht's awards include the Specsavers National Book Awards 2001 Lifetime ... Rapid Effective Assistance for Children with Potentially Terminal illness; Alzheimer's Society "Singing for the Brain" groups; ... Action for Blind People; InterAct Reading Service; Mildmay Mission Hospital; Dementia Care; Resource: The Jewish Employment ...
Mackenzie Vaughan Hospital
"Quality care close to home for residents of Vaughan" (Press release). Ontario Ministry of Health and Long-Term Care. 25 October ... The transit terminal will be used for services by York Region Transit (including Viva Silver), Go Transit, and other operators ... Other services include: surgical services and operating rooms diagnostic imaging ambulatory clinics intensive care acute care ... "YRT/Viva Transit Terminal adjacent to Mackenzie Vaughan Hospital" (PDF). City of Vaughan. 1 October 2015. Retrieved 13 April ...
Russell and Fern de Greeff Hospice House
... care Bereavement care Volunteer services Inpatient care Respite care Nutritional counseling Medications related to the terminal ... Louis, Mo., provides traditional hospice care to terminally ill individuals who do not have a caregiver available to care for ... He and his wife, Fern, saw a need and established an endowment for a freestanding hospice house to care for terminally ill ... In 2006, the Hospice House expanded to care for 18 patients from the original 10 patients. Fern de Greeff died at age 100 in ...
The negative battery terminal is connected to the car's chassis. The Hudson Motor Car Company was the first to use a ... "Basic Battery Care". Popular Mechanics. 2006-03-29. Retrieved 2016-02-17. Elert, Glenn. "Voltage of a Car Battery". ... Corrosion at the battery terminals can prevent a car from starting due to electrical resistance, which can be prevented by the ... "Description and treatment of sulphated batteries". O. A. Witte (1922). "The Automotive Storage Battery Its Care and Repair". ...
Eleanor Rigby (novel)
His illness is terminal, and because of drug abuse, he has only a short time to live. Jeremy's introduction into Liz's life ... He has traveled through the foster-care system of British Columbia, residing with many families who abused him. He eventually ... Liz's son Jeremy, who was sent out for adoption, has a terminal case of multiple sclerosis. ...
accessed 11/9/2012) Geographic Variation in Health Care Spending and Promotion of High-Value Care Institute of Medicine updated ... Interview with Richard Heffner, "Do We "Waste" Money on Terminal Patients?" Open Mind TV Show, PBS, 4/12/28. Interview with ... Pham HH, Schrag D, O'Malley AS, Wu B, Bach PB (2007). "Care patterns in Medicare and their implications for pay for performance ... Bach PB, Pham HH, Schrag D, Tate RC, Hargraves JL (2004). "Primary care physicians who treat blacks and whites". The New ...
My Best Friend's Girl (novel)
Adele had terminal cancer so she died early in the novel. Luke Wiseman - Kamryn's boss and later boyfriend. Luke was a product ... of a teenage pregnancy and was taken into care at a young age. He sees Tegan as his own daughter and is rather protective of ... However, she visits London anyway but when at the hospital she discovers that Adele has terminal cancer and is going to die ...
... nor does it care about blanks or line breaks. The grammar uses these terminal symbols but does not define them. They are always ... For the terminal '0' (i.e. where x = '0') this results in: Item set 1 B → 0 • and for the terminal '1' (i.e. where x = '1') ... the terminals '0' and '1' and the nonterminal B must be considered. For the terminals, note that the resulting closed item sets ... The action table is indexed by a state of the parser and a terminal (including a special terminal $ that indicates the end of ...
Several shipbuilders and tour operators that visit the Great Barrier Reef operate from the Reef Terminal on the entrance to the ... doi:10.1016/S1040-6182(02)00142-8. "Who is taking care of Trinity Inlet ? :: ABC Far North Qld". "Cairns Esplanade Reef Fleet ... Terminal - Great Barrier Reef Cruises - Cairns Australia". ...
The terminal and bridging CO ligands interchange rapidly. In NbCl5, there are two bridging and eight terminal chloride ligands ... When describing coordination complexes care should be taken not to confuse μ with η ('eta'), which relates to hapticity. ... In the case of ZrCl4, there are both terminal and doubly bridging chloride ligands. In rhodium(II) acetate, the four acetate ... Ligands that are not bridging, are called terminal ligands (see figure). Virtually all ligands are known to bridge, with the ...
... nor does it care about blanks or line breaks. The grammar uses these terminal symbols but does not define them. They are always ... to discard the lookahead terminal symbol and to read the next terminal symbol, but many other programmed actions are possible, ... STOP, then, represents a configuration where the state at the top of the stack and the lookahead terminal symbol is within the ... ERROR, then, represents a configuration where the state at the top of the stack, and the lookahead terminal symbol is not ...
Downtown Fort William, Ontario
Thunder Bay Transit operates a bus terminal in the core. Routes that use the terminal include 1 Mainline, 2 Crosstown, 3 ... Joseph's Care Group in Victoriaville Civic Centre, the Ridgeway Clinic, the Fort William Clinic, and the Spence Clinic. The ... Joseph's Care Group. (November 30, 2007) Retrieved March 2, 2008. Ridgeway Clinic at Profile Canada Fort William Clinic at ... Crime is recognized to be a problem in the south core, especially near the Brodie Street bus terminal. Thunder Bay Police ...
Kochuveli railway station
Kochuveli, the Satellite Terminal of Trivandrum is also poised for growth, with present 6 platforms and a total of 10 once ... Coach care centre which is undergoing construction, is yet to be completed. Construction of a sickline complex, two pit lines ... Kochuveli railway station, is a satellite passenger rail terminal of Thiruvananthapuram city in the Indian state of Kerala. It ... The Eastern side has the satellite terminal from where the trains originating from Kochuveli operates and the old railway ...
Kuala Lumpur Kepong Berhad
Bhd., a common user liquid storage terminal at Westport, Port Klang. KLK owns KL-Kepong Country Homes Sdn. Bhd. Notable ... Crabtree & Evelyn is a retailer of personal care products, toiletries, home fragrance products and fine foods with the ... personal care products, toiletries and fine foods) with worldwide presence. The company is listed on the Bursa Malaysia and is ...
Dead on arrival
For example, it may not represent the standard of care for patients with terminal diseases such as advanced cancer. In addition ... Further information: Texas Futile Care Law. Regardless of the patient, a pronouncement of death must always be made with ... jurisdictions such as Texas permit withdrawal of medical care from patients who are deemed unlikely to recover. ...
The Trillium Hospital Bus Terminal is a MiWay bus terminal located on the northern side of the Mississauga Hospital site, ... Mississauga Transit... has a bus stop on [Mississauga Hospital] property located across from the Emergency and Family Care ... The bus terminal has no ticketing services and contains a bus shelter. All routes are wheelchair-accessible (). "History - ... Rachlis, Michael (2005). Public Solutions to Health Care Wait Lists. Canadian Centre Policy Alternatives. p. 5. ISBN 978-0- ...
"American Journal of Respiratory and Critical Care Medicine. 163 (3 Pt 2): S18-21. doi:10.1164/ajrccm.163.supplement_1.2011113. ... with an amidation at the C-terminus. Substance P is released from the terminals of specific sensory nerves. It is found in ... When the innervation to substance P nerve terminals is lost, post-synaptic cells compensate for the loss of adequate ... Supportive Care in Cancer. 9 (5): 350-4. doi:10.1007/s005200000199. PMID 11497388.. ...
Here she guards and cares for them for about five months (160 days) until they hatch. In colder waters, such as those off ... from the terminal organ of the reproductive tract (the cephalopod "penis") into the female's mantle cavity. The ... Young octopuses learn nothing from their parents, as adults provide no parental care beyond tending to their eggs until the ... The female deposits fertilised eggs in a den and cares for them until they hatch, after which she also dies. ...
Internet of things
Elder care. One key application of a smart home is to provide assistance for those with disabilities and elderly ... Very small aperture terminal (VSAT) - Satellite communication technology using small dish antennas for narrowband and broadband ... Standards for UIDs ("unique" identifiers) and RFID of fast-moving consumer goods (consumer packaged goods), health care ... Applications have been established for point-of-care medical diagnostics, where portability and low system-complexity is ...
Some primary care providers may also take care of hospitalized patients and deliver babies in a secondary care setting. ... modern branch of clinical medicine that deals with pain and symptom relief and emotional support in patients with terminal ... Urgent care focuses on delivery of unscheduled, walk-in care outside of the hospital emergency department for injuries and ... See also: Health care, clinic, hospital, and hospice. Provision of medical care is classified into primary, secondary, and ...
The alkali metals and their hydrides react with acidic hydrocarbons, for example cyclopentadienes and terminal alkynes, to give ... The alkali metals also react with water to form strongly alkaline hydroxides and thus should be handled with great care. The ... The aggregates are held together by delocalised covalent bonds between lithium and the terminal carbon of the butyl chain. ...
East New York, Brooklyn
N-Terminal domain antagonistsEdit. N-Terminal domain AR antagonists are a new type of AR antagonist that, unlike all currently ... Bockting W, Coleman E, De Cuypere G (2011). "Care of transsexual persons". N. Engl. J. Med. 364 (26): 2559-60; author reply ... Phyllis Carolyn Leppert; Jeffrey F. Peipert (2004). Primary Care for Women. Lippincott Williams & Wilkins. pp. 277-. ISBN 978-0 ... Vance SR, Ehrensaft D, Rosenthal SM (2014). "Psychological and medical care of gender nonconforming youth". Pediatrics. 134 (6 ...
腎上腺素 - 維基百科，自由的百科全書
Care of the Critically Ill Surgical Patient（英語：Care of the Critically Ill Surgical Patient） (CCrISP) ... 軸突終末（英語：Axon terminal）. 突觸間隙（英語：Synaptic cleft） ... Acute Care of at-Risk Newborns（英語：Acute Care of at-Risk Newborns） (ACoRN) ... Nancy caroline's emergency care in the streets. 7. [S.l.]: Jones And Bartlett Learning. 2012: 557 [2016-03-19]. ISBN ...
Ellis Island Immigrant Hospital
"ELLIS ISLAND ENDS ALIEN PROCESSING; Last Detained Person Leaves -- 20,000,000 Immigrants Cared For in 62 Years". The New York ... The laundry-hospital outbuilding is south of the ferry terminal, and was constructed in 1900-1901 along with the now-demolished ... its Contract Hospital relationship with the Health Department of New York and Long Island College Hospitals who had been caring ...
Palliative care. Palliative care specialists state that many requests for euthanasia arise from fear of physical or ... On 1 August 2014, after euthanasia advocate Max Bromson, 66, who suffered from terminal bone cancer, ended his life with ... "We have too many people who have the best palliative care in the world and they still want to know that they can put an end to ... Nitschke had encouraged Crick to enter palliative care, which she did for a number of days before returning home again. She had ...
Nurturant maternal care, in turn, may enhance HPA functioning in at least two ways. First, maternal care is crucial in ... CRH and vasopressin are released from neurosecretory nerve terminals at the median eminence. CRH is transported to the anterior ... Thus, if a developing child (i.e., fetus to neonate) is exposed to ongoing maternal stress and low levels of maternal care (i.e ... Whereas maternal care improves cardiac response, sleep/wake rhythm, and growth hormone secretion in the neonate, it also ...
Hyperimmunoglobulin E syndrome
... leaving them in the care of resident merchants. The trading post at Grand Bassam in Ivory Coast was left in the care of a ... The southern terminals of the trans-Saharan trade routes were located on the edge of the desert, and from there supplemental ... The more important terminals-Djenné, Gao, and Timbuctu-grew into major commercial centres around which the great Sudanic ...
Southern Pacific Transportation Company
2001). Applied health research manual: anthropology of health and health care (3rd ed.). Amsterdam: Het Spinhuis. ISBN ... However, instead of reaching a terminal market after the regional forwarding centres, the produce will reach an export market ... They are then moved to terminal markets such as in New Delhi, Kochi, and Bombay. ...
... and involved with terminal care research and engaged with international universities. She is best known for her role in the ... Hartley, Nigel (21 November 2013). End of Life Care. ISBN 9780857003362. .. *^ Hartley, Nigel; Payne, Malcolm (15 May 2008). ... The work of the arts team is reflected in two publications: End of Life Care: A Guide for Therapists, Artists and Arts ... The Care of the Dying Patient and His Family; documentation in Medical Ethics, no. 5 (1975), published by the London Medical ...
The City that Care Forgot has been used since at least 1938, and refers to the outwardly easy-going, carefree nature of the ... The New Orleans Union Passenger Terminal is the central rail depot and is served by the Crescent, operating between New Orleans ... This same terminal also serves the Canal Street/Gretna Ferry, connecting Gretna, Louisiana for pedestrians and bicyclists only ... Metropolitan New Orleans is a major regional hub for the health care industry and boasts a small, globally competitive ...
Index of HIV/AIDS-related articles
P24 - package insert - palliative - palliative care - pancreas - pancreatitis - pancytopenia - pandemic - pap smear - papilloma ... long terminal repeat sequence (LTR) - long-term nonprogressors - LTR - lumbar - lumbar puncture - lymph - lymph nodes - ... HAART - hairy leukoplakia - half-life - HAM/TSP - Health Care Financing Administration (HCFA) - Health Resources and Services ... New York Cares - NIAID - NICHD - night sweat - NIH - NK cell - NLM - NNRTI - non-Hodgkin's lymphoma (NHL) - non-nucleoside ...
Though one passenger was killed during the explosion, they took care of the injured passengers. ... Social Movements and the Transformation of American Health Care. Oxford University Press. p. 294. ISBN 978-0-19-974214-1. .. ... and health care than the general population which could affect overall health and cancer risk. ...
Acute inhalation injury
What have we learned from experimental animal models? Crit Care Clin. 2:455-70. Uchida T, Makita K. (2008) Acute lung injury ... Bronchiolitis obliterans with organized pneumonia can ensue when granulation tissue accumulates in the terminal airways and ... Am J Respir Crit Care Med. 168:568-74. Matalon S, Maull EA. (2010) Understanding and treating chlorine-induced lung injury. ...
The US$11.1 billion East Side Access project, which will bring LIRR trains to Grand Central Terminal in Manhattan, is under ... with occupations spread relatively evenly across the health care, retail trade, manufacturing, construction, transportation, ... The midsection of Queens is crossed by the Long Island straddling terminal moraine created by the Wisconsin Glacier. The ... Originally opened in 1939, the airport's two runways and four terminals cover 680 acres (280 ha), serving 28.4 million ...
For severe TBI (i.e. those TBI patients in neurointensive care unit), the biofluid type where the biomarker can be detected ... Neuronal cell body injury markers include Neuron-specific enolase (NSE), Ubiquitin C-terminal hydrolase-L1 (UCH-L1), Astroglial ... whether it is for monitoring severe TBI patients in the intensive care unit, or triaging mild and moderate TBI patients in the ...
Health in India
In planning health care structure for the future, it is desirable to move from a 'fee-for-service' mechanism, to address the ... sometimes becoming terminal Vitamin A deficiency, which can lead to blindness or a weakened immune system Iodine deficiency, ... Inadequate care of these women already underdeveloped, especially during pregnancy, leads them in turn to deliver underweight ... In addition, only 15 per cent of mothers receive complete antenatal care and only 58 per cent receive iron or folate tablets or ...
எயிட்சு - தமிழ் விக்கிப்பீடியா
Physicians AIDS Care (Chic Ill) 1 (2): 53-62. பப்மெட் 12942677. *↑ Pollok RC (2001). "Viruses causing diarrhoea in AIDS". ... 1986). "Transactivation of the human immunodeficiency virus long terminal repeat sequences by DNA viruses". Proc. Natl. Acad. ... Care 29 (2): 361-78. பப்மெட் 12391716. *↑ Nicholas PK, Kemppainen JK, Canaval GE, et al. (February 2007). "Symptom management ... and self-care for peripheral neuropathy in HIV/AIDS". AIDS Care 19 (2): 179-89. doi:10.1080/09540120600971083. பப்மெட் 17364396 ...
Diabetes Care. 27 (10): 2491-2. doi:10.2337/diacare.27.10.2491. PMID 15451922.. ... alpha-amidating monooxygenase amidates peptide hormones by removing the glyoxylate residue from their c-terminal glycine ... "Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer" ...
Planning the Transition to End-of-Life Care in Advanced Cancer (PDQ®)-Health Professional Version - National Cancer Institute
... and families for the transition to end-of-life care in advanced cancer. ... Expert-reviewed information summary about the preparation needed by health care providers, patients, ... Yun YH, Lee MK, Kim SY, et al.: Impact of awareness of terminal illness and use of palliative care or intensive care unit on ... Palliative care is both a philosophy of care and an organized, highly structured system for delivering care. Palliative care ...
Transfusion dependence a barrier to quality end-of-life care for some with leukemia | EurekAlert! Science News
... associates this reduced access and consequent diminished use of hospice services with a reduced quality of end-of-life care for ... access to high-quality end-of-life care appears to be reduced in those dependent on blood transfusions, according to a new ... "Our findings suggest that allowing reimbursement for palliative transfusions in patients with terminal leukemia would be ... Building on previous research that correlated a longer duration of hospice care with increased quality of end-of-life care, ...
'Prison Terminal': Kidnappers Care for Murderers at End of Life - ABC...
Prison Terminal: Kidnappers Care for Murderers at End of Life. * By Susan Donaldson James ... "Prison Terminal" will have its world premiere at the Irvine International Film Festival in California. Oscar nominations come ... Sales answers critics who say those who have committed violent crimes dont deserve compassion: "We have to be better at caring ... His unlikely comforters -- kidnappers and murderers -- are paid nothing for their hours of care-giving to a growing population ...
Care and support through terminal illness | Marie Curie
Last year we cared for over 40,000 people across the UK. ... We provide care and support for people living with any terminal ... Hospice care. Our nine hospices give round-the-clock, expert care and support to people living with a terminal illness - ... 5 a month - over a year, your gift could pay for three hours of vital nursing care for someone with a terminal illness in their ... Marie Curie Nurses give care and support to people living with a terminal illness in their own homes. ...
Van Der Steen Jenny | Palliative Care | Terminal Illness
Antea Worldwide Palliative Care ConferenceRome, 12-14 November 2008 ABSTRACT FORM Presenting author ... ... Palliative care for cancer patients • Palliative care for non cancer patients • Paediatric palliative care • Palliative care ... Session: Training & Research in palliative care palliative care policies Chair: Dott. Franco Toscani and law • Palliative care ... Volunteering in palliative care . • Rehabilitation in palliative care • Palliative care quality indicators • Neurology in ...
Terminal cancer care and patients' preference for place of death: a prospective study. | The BMJ
Terminal cancer care and patients preference for place of death: a prospective study. British Medical Journal 1990; 301 :415 ... Terminal cancer care and patients preference for place of death: a prospective study.. British Medical Journal 1990; 301 doi: ... Terminal cancer care and patients preference for place of death: a prospective study. ... Terminal cancer care and patients preference for place of death: a prospective study. ...
Browsing Publications by Subject "Terminal Care"
Pellegrini Claudio | Palliative Care | Terminal Illness
Antea Worldwide Palliative Care ConferenceRome, 12-14 November 2008 ABSTRACT FORM Presenting author ... ... palliative care policies and law • Palliative care: from villages to metropolies • Space, light and gardens for the Session: ... Palliative care for the elderly approach. • The actors of palliative care It will be necessary to train physiotherapists ... Volunteering in palliative care • Rehabilitation in palliative care . • Workshop on core curricula ...
Browsing Technical documents by Subject "Terminal Care"
Black Patients With Terminal Cancer More Likely To Choose Aggressive Care | EmaxHealth
... what kind of care they wanted at the end of life, and then documented the kind of care they actually received and the place of ... or advance care planning, when taking into account the patients own preference for more-aggressive care. It was clear that a ... Black patients with advanced cancer were more likely than whites to die in a hospital intensive care unit, reflecting a greater ... "This is the first study focused on black/white differences that prospectively asked [terminal cancer patients] ...
terminal illness - Social Care Online
Beyond the terminal: Palliative care
... but now it is considered an integral part of the care that should be available to patients with serious respiratory ... ... Palliative care was once reserved for patients when all curative options had been exhausted and death was imminent, ... Beyond the terminal: Palliative care. April 15, 2008 Palliative care was once reserved for patients when all curative options ... Palliative care barriers must be addressed for heart/stroke patients. August 9, 2016 A new policy statement on palliative care ...
Clinical Care of the Terminal Cancer Patient. | Annals of Internal Medicine | American College of Physicians
Clinical Care of the Terminal Cancer Patient.. Ann Intern Med. 1983;99:428. doi: 10.7326/0003-4819-99-3-428_2 ... The care of patients with neoplastic diseases is often approached as though one is changing gears in a car: the treatment gear ... Care of the Adult Cancer Survivor Annals of Internal Medicine; 158 (11): ITC6-1 ... In many sections this book suffers from this problem, presuming that there are patients with terminal and nonterminal cancer. ...
Chronic and Terminal Illness: new perspectives on caring and carers - Oxford Scholarship
This book provides a critique of the theoretical concept of caring, carers, and caregivers. The material is based on empirical ... This new evidence is used to make suggestions about possible ways forward within health and social care practice. ... or emotional care to others already known to them by virtue of kinship, co-habitation, or friendship, rather than carers ... are an invaluable free resource and there is an increasing amount of research into their role and the experiences of caring for ...
Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based...
Initiation of palliative care. The primary exposure was a patients first encounter with palliative care across all care ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ...
NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications...
Your Name) has forwarded a page to you from Diabetes Care Message Body (Your Name) thought you would like to see this page from ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ...
NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications...
Your Name) has forwarded a page to you from Diabetes Care Message Body (Your Name) thought you would like to see this page from ... N-terminal pro brain natriuretic peptide reflects long-term complications in type 1 diabetes. Scand J Clin Lab Invest 2010;70: ... Plasma N-terminal pro-brain natriuretic peptide in Type 1 diabetic patients with and without diabetic nephropathy. Diabet Med ... N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in ...
End Stage Dementia: A Terminal Disease Needing Palliative Care
Hopefully, recognizing that end stage dementia is a terminal condition will result in improved care---care focused on the ... "Were not talking about aggressive care versus no care," he said. "Palliative care is aggressive and attentive and focused on ... As a registered nurse, I find that palliative care medicine is one of the most intimate, most caring and beautiful forms of ... the difficulty obtaining hospice when the family wants both palliative care and traditional disease focused care and (2) the ...
Caring for someone with a terminal illness: what to expect
It explains what changes to expect when caring for a loved one at the end-of-life. ... This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging ... Caring for someone with a terminal illness: what to expect. Author(s): Lakehead University- Centre for Education and Aging ... This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging ...
Terminal Care | Profiles RNS
"Terminal Care" by people in this website by year, and whether "Terminal Care" was a major or minor topic of these publications ... "Terminal Care" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Medical and nursing care of patients in the terminal stage of an illness. ... Below are the most recent publications written about "Terminal Care" by people in Profiles. ...
Ask The Treatment Expert: Is a Kennedy Terminal Ulcer a pressure injury? - McKnight's Long Term Care News
A Kennedy Terminal Ulcer is a pressure injury that develops on residents ... Is a Kennedy Terminal Ulcer a pressure injury? What are the main characteristics? ... A Kennedy Terminal Ulcer is a pressure injury that develops on residents as they are dying. The skin is the largest organ. Thus ... A Kennedy Terminal Ulcer tends to have a sudden rapid onset, developing in a matter of hours. Clinicians have reported the ...
Care for any terminal illness - David's story - Saint Michael's Hospice
Care for any terminal illness - Davids story. David Bevins, 66, of Harrogate, has been living with Chronic Obstructive ... Harrogate District Hospice Care is known locally as Saint Michaels Hospice.. Registered Charity No. 518905 Company No. 2121179 ... One in five of our patients is cared for thanks to a gift left in a will. ... One in every two people is touched by hospice care, which makes what we do very relevant. ...
Terminal Illness (Provision of Palliative Care and Support for Carers) - Hansard
Even those with a terminal illness are not being identified as in need of referral for palliative care. In some regions, one in ... That leave be given to bring in a Bill to require the provision of comprehensive palliative care to those with terminal ... At a time when there is chronic underfunding in social care, there is a serious lack of high-quality community care and support ... We need to have properly funded nationwide palliative care provision that is integrated with local authorities, community care ...
Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal Or Excessive Sedation / Organ Donation / Dcd Or...
by APFLI , Jun 15, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 29, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 16, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 16, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ...
A retrospective study on clinical course and outcomes in patients with terminal cancer receiving home medical care provided by...
A retrospective study on clinical course and outcomes in patients with terminal cancer receiving home medical care provided by ... In Japan, only a few hospitals play a role in home medical care including end-of-life care. We retrospectively investigated the ... not wanting to die at home when beginning home medical care , Commitment of hospitals to provide back-up beds could contribute ... who complained of the difficulty in continuing home care owing to family caregiving burden. Significant factors not to die at ...
Kieran Quinn: We need to raise awareness of the benefits of palliative care services for patients with terminal non cancer...
Kieran Quinn: We need to raise awareness of the benefits of palliative care services for patients with terminal non cancer ... But when I referred these patients to our palliative care teams who were well equipped to provide care for them at home and ... After all, many palliative care programmes were established in cancer centres to care for patients with cancer. ... Palliative care in patients with heart failure. BMJ 2016;353:i1010.. 9 Steinhauser KE, Arnold RM, Olsen MK, et al. Comparing ...
Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. A prospective...
Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. A prospective ... Context: Amino-terminal pro-brain-type natriuretic peptide is known to predict outcome in patients with heart failure, but its ... Anesthesiology and Intensive Care Cardiac and Cardiovascular Systems Clinical Medicine Identifiers. urn:nbn:se:liu:diva-122759 ... role in an intensive care setting is not yet fully established. Objective: To assess the incidence of elevated amino-terminal ...
HospiceIllnessesHealthCompassionatePatient'sOncologyLife careChronicAmino-terminal pro-brain natriurLiving with a terminal illnessDiagnosisPrognosisMultidisciplinaryHospice Care ServicesLiverpool Care PathwaySupportive and palliative careModern palliative careRegarded as a terminal illnessPathwayHealth CareNatriuretic peptideDiseaseSymptomsCliniciansHealthcareRespiteCancer careNurseUlcerPalliat CareHaving a terminal illnessSearchAbstractClinical CareLifeIllnesses or conditionsAilmentIntensiveHospicesMedicalPalliative approachProvisionSupportPediatricArticle examinesOne'sTerminally ill patientsRelieveCentersExamines
- This section summarizes the information that will allow oncology clinicians and patients with advanced cancer to create a plan of care to improve QOL at the end of life (EOL) by making informed choices about the potential harms of continued aggressive treatment and the potential benefits of palliative or hospice care. (cancer.gov)
- The study associates this reduced access and consequent diminished use of hospice services with a reduced quality of end-of-life care for these patients. (eurekalert.org)
- Building on previous research that correlated a longer duration of hospice care with increased quality of end-of-life care, this study analyzed additional factors that have been associated with poorer end-of-life care. (eurekalert.org)
- Researchers found that, compared with leukemia patients who did not enroll in hospice care, those who did were far less likely to die in the hospital (3 percent vs 75 percent) or receive chemotherapy during the last two weeks of life (5 percent vs 16 percent). (eurekalert.org)
- Additionally, they found that patients who needed periodic blood transfusions spent about half as much time in hospice care compared with leukemia patients who were not reliant on these transfusions. (eurekalert.org)
- We found a significant association between transfusion dependence and less meaningful use of hospice care at the end of life among patients with leukemia," said Thomas W. LeBlanc, MD, associate professor of medicine at Duke Cancer Institute in Durham, NC, and senior author of the study. (eurekalert.org)
- Transfusion-dependent patients were significantly more likely to spend fewer than three days in hospice care (27 percent) compared with patients who were not transfusion-dependent (19 percent), he said, associating longer time spent in hospice care with more meaningful use of the service. (eurekalert.org)
- According to Dr. LeBlanc, one of the barriers to the use of hospice care by transfusion-dependent patients with advanced leukemia is that many clinicians consider blood transfusions to be disease-modifying therapy rather than comfort care, as transfusions can help some patients to live longer and feel better. (eurekalert.org)
- Another is that, under Medicare's reimbursement protocol, the cost of blood transfusions is not compensated separately, but must be covered within the per-diem rate paid for hospice care, reducing the ability of hospice agencies to provide transfusion support as part of their services. (eurekalert.org)
- Furthermore, the logistical complexities of blood transfusion also often preclude providing the service in patients' homes, where most hospice patients receive care. (eurekalert.org)
- Patients were considered transfusion-dependent if, within 30 days before death or enrollment in hospice care, they received two or more blood transfusions at least five days apart. (eurekalert.org)
- Results showed that from 2001-2011, slightly more transfusion-dependent patients enrolled in hospice care than patients who were not transfusion-dependent (47 versus 43 percent), but that their median length of stay in hospice care was significantly shorter than those who were not transfusion-dependent (6 versus 11 days). (eurekalert.org)
- This suggests that clinicians tend to enroll patients in hospice during the very last few days of life, but we know from other studies that the earlier patients enter hospice care, the more likely they are to obtain the full benefit of what hospice can offer in terms of an improved quality of life," said Dr. Olszewski, lead study author. (eurekalert.org)
- 1 ] Anticipating the end of life (EOL) and making health care decisions about appropriate or preferred treatment or care near the EOL is intellectually challenging and emotionally distressing for patients with advanced cancer, their families and friends, oncology clinicians, and other professional caregivers. (cancer.gov)
- Utilization of burdensome and expensive health care resources of little therapeutic benefit. (cancer.gov)
- Atlanta, Dec. 11, 2017) -- For patients with advanced leukemia, access to high-quality end-of-life care appears to be reduced in those dependent on blood transfusions, according to a new study being presented during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta. (eurekalert.org)
- These findings suggest that patients are having to choose between getting the transfusions they need and getting high-quality end-of-life care," Dr. LeBlanc said. (eurekalert.org)
- The impetus for our study was inspired by my experiences caring for patients with noncancer illness such as heart failure, chronic obstructive pulmonary disease and dementia. (bmj.com)
- Terminal care is not just cancer care but other relevant diseases, which include heart failure , respiratory failure , severe chronic kidney disease , hepatic failure , as well as certain neurological diseases such as multiple sclerosis and motor neurone disease , and dementia . (51digg.info)
- Providing care for a loved one facing a chronic or life-limiting illness or disease can prove stressful and exhausting, especially as the dying process begins, but also the ultimate act of love. (verywellhealth.com)
- With COVID-19 changing life as we know it on a daily basis, HealthiVibe wants to hear from patients with chronic and terminal health conditions. (thedisableddivablog.com)
- HealthiVibe is fielding a survey from today through April 10th called " Interruption in Care " to gain feedback from patients living with chronic or terminal health conditions to gauge how COVID-19 is impacting your life right now. (thedisableddivablog.com)
- Please share it with your friends, family, and contacts that have either a chronic or terminal illness. (thedisableddivablog.com)
- Each edition has received widespread critical acclaim, and the book is used across the world by the wide range of health care professionals involved in the care of patients with a terminal illness, or chronic, progressive conditions. (worldcat.org)
- Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. (diva-portal.org)
- Objective: To assess the incidence of elevated amino-terminal pro-brain natriuretic peptide (NT-pro-BNP) on admission to intensive care and its relation to death in the ICU and within 30 days. (diva-portal.org)
- Objectives The purpose of this study was to determine the effect of amino-terminal pro-brain natriuretic peptide (N-BNP) on the diagnostic accuracy of heart failure (HF) in primary care. (onlinejacc.org)
- Amino-terminal pro-brain natriuretic peptide is present in high levels in cardiac dysfunction and may improve the diagnostic accuracy of HF in primary care. (onlinejacc.org)
- Advanced dementia is a terminal diagnosis. (geripal.org)
- For people with motor neurone disease, early access to palliative care is essential, as one third of people with motor neurone disease die within a year of diagnosis. (parliament.uk)
- Better communication is needed and more sensitivity and empathy are required from health professionals when discussing an end-of-life diagnosis and options such as palliative care. (parliament.uk)
- Significant factors not to die at home were 'dyspnea' , 'no secondary family caregiver' , 'not being notified of a cancer diagnosis' , and 'not wanting to die at home when beginning home medical care' , Commitment of hospitals to provide back-up beds could contribute to reducing the mental burden of patients and their caregivers during home medical care. (go.jp)
- This evidence report presents the results of a systematic review to evaluate B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) as promising markers for heart failure diagnosis, prognosis, and treatment. (ahrq.gov)
- Background The accurate diagnosis of patients with suspected HF presenting in primary care is difficult. (onlinejacc.org)
- The accurate diagnosis of heart failure (HF) presenting in primary care is difficult. (onlinejacc.org)
- For patients diagnosed with HF in primary care, only a minority have that diagnosis confirmed after cardiologic assessment (2) . (onlinejacc.org)
- Hence, there is a need for a diagnostic test that can improve the accuracy of HF diagnosis in primary care. (onlinejacc.org)
- Communicating with dying patients within the spectrum of medical care from terminal diagnosis to death. (semanticscholar.org)
- Learn about communication skills that support a patient-centered practice and how to talk with adults and children about their diagnosis, prognosis, and transition to end-of-life care in this expert-reviewed summary. (oncolink.org)
- Palliative care can start at the time of diagnosis. (ohsu.edu)
- Terminal patients have many options for disease management after diagnosis. (wikipedia.org)
- Palliative care focuses on addressing patients' needs after disease diagnosis. (wikipedia.org)
- Black patients with advanced cancer were more likely than whites to die in a hospital intensive care unit, reflecting a greater preference among blacks for life-extending treatment even in the face of a terminal prognosis, according to a study led by researchers at Dana-Farber Cancer Institute in Boston. (emaxhealth.com)
- This includes (1) the difficulty obtaining hospice when the family wants both palliative care and traditional disease focused care and (2) the limitation of hospice to patients with a six month prognosis---Mitchell's findings clearly show patients need palliative care long before the final six months. (geripal.org)
- Our aim was to explore experiences of giving or receiving a prognosis and advanced palliative care planning (ACP) for those with HF. (ovid.com)
- Obamacare's prognosis is terminal - long live healthcare choice! (e-rockford.com)
- The physiotherapist in this field, is one of the components of the multidisciplinary team that takes care of the patient. (scribd.com)
- Palliative care for cancer patients multidisciplinary. (scribd.com)
- Terminal patients requiring palliative care in a multidisciplinary fashion are taken care of under this roof. (jaslokhospital.net)
- Others highlighted the need to deliver problem-based, individualised care but felt constrained sometimes by the lack of multidisciplinary ACP. (ovid.com)
- Both the multidisciplinary palliative care team and the neurology team are essential in providing a high standard of care and allowing quality of life (both patient and carer) to be maintained. (usakochan.net)
- Financial Assistance - Hospice care services are covered by Medicare and Medicaid and most private insurers. (allcaringhospice.com)
- The Life Path Hospice Care Services Hospice team is standing by. (lifepathhospicecare.com)
- Life Path Hospice Care Services is a health care community offering individuals a place to recover, rehabilitate and/or reside, depending on their specific needs. (lifepathhospicecare.com)
- It was published by the Leadership Alliance for the Care of Dying People, which was established following an independent review of the Liverpool Care Pathway (LCP), commissioned by the UK government and chaired by Baroness Neuberger. (51digg.info)
- Report on the LCP(Liverpool care pathway) This report sets out recommendations regarding the Liverpool Care Pathway and end of life care following an independent review of the LCP. (majortests.com)
- ESMO, the leading professional organisation for medical oncology, published a position paper on supportive and palliative care in its leading scientific journal, Annals of Oncology today. (medicalxpress.com)
- This summary is reviewed regularly and updated as necessary by the PDQ Supportive and Palliative Care Editorial Board, which is editorially independent of the National Cancer Institute (NCI). (oncolink.org)
- Consistent with other studies demonstrating benefit, the use of hospice care is associated with better quality-of-care outcomes, including patient-centered care metrics," study leader Ruth Kleinpell and colleagues write in the journal BMJ Supportive and Palliative Care, online August 16. (reuters.com)
- We will explore real-life stories of how modern palliative care is delivered and how it supports individuals and families for the full duration of a life-limiting illness. (ausmed.com.au)
- Communication issues and the psychiatric, spiritual, and psychosocial issues so integral to modern palliative care are covered in depth. (worldcat.org)
- Health care providers do not necessarily make more money for longer hospice stays. (physiciansforlife.org)
- Kieran Quinn , General Internal Medicine and Palliative Care, Sinai Health System and PhD Candidate, Clinical Epidemiology & Health Care Research, Institute of Health Policy, Management and Evaluation, Eliot Phillipson Clinician-Scientist Training Program, University of Toronto. (bmj.com)
- The health care cost of dying: a population-based retrospective cohort study of the last year of life in Ontario, Canada. (bmj.com)
- Palliative and terminal care : health care needs assessment : the epidemiologically based needs assessment reviews, second series / edited by Andrew Stevens and James Raftery. (who.int)
- Health care needs assessment. (who.int)
- Originally published in: Health care needs assessment. (who.int)
- Effective communication in cancer care between the health care team, cancer patients, and their family is important. (oncolink.org)
- It does not provide formal guidelines or recommendations for making health care decisions. (oncolink.org)
- Moreover, the need for truly informed consent and the patient's right to health care information and compassionate care create ethical, legal, and humanistic mandates for competency in oncology communication. (oncolink.org)
- There is an interest in the benefits of telecare health care services, especially among patients who require hospice care. (bartleby.com)
- Telecare is not a new phenomenon in the health care industry, it has evolved into an important aspect of health care and hospice. (bartleby.com)
- Introduction Kolcaba defines comfort care for nursing as a "philosophy of health care that focuses on addressing physical, psychospiritual, sociocultural, and environmental comfort needs of patients (kolcaba, 2003, p. 252). (bartleby.com)
- Choice of health care professional. (govtrack.us)
- Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (clinicaltrials.gov)
- Someone who can't afford health care may be pressured into assisted suicide. (majortests.com)
- Defence: Canada has health care and it is becoming more popular in the United States. (majortests.com)
- reflection The right to consent and refuse treatment is a fundamental right that must be honoured by health care staff. (majortests.com)
- Clinical practice guidelines are defined as "systematically developed statements to assist both practitioner and patient decisions about appropriate health care for specific clinical circumstances" (Field and Lohr, 1990, 1992). (nap.edu)
- Cemeteries RA638 Immunity and immunization in relation to public health RA639-642 Transmission of disease RA643-645 Disease (Communicable and noninfectious) and public health RA645.3-645.37 Home health care services RA645.5-645.9 Emergency medical services RA646-648.3 War and public health RA648.5-767 Epidemics. (wikipedia.org)
- OBJECTIVE Circulating levels of NH 2 -terminal probrain natriuretic peptide (NT-proBNP), a marker of acute heart failure, are associated with increased risk of cardiovascular disease (CVD) in the general population. (diabetesjournals.org)
- NH 2 -terminal probrain natriuretic peptide (NT-proBNP) is the inactive molecule resulting from cleavage of brain natriuretic peptide prohormone ( 1 ). (diabetesjournals.org)
- Context: Amino-terminal pro-brain-type natriuretic peptide is known to predict outcome in patients with heart failure, but its role in an intensive care setting is not yet fully established. (diva-portal.org)
- Brain natriuretic peptide (BNP), released mainly by the ventricle, is elevated in HF and offers promise as a diagnostic test in primary care. (onlinejacc.org)
- How are brain natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels used in the evaluation of left ventricular (LV) function? (medscape.com)
- Such an approach is often counterproductive, because most patients with treatable cancer suffer with terminal problems and, more importantly, most terminally ill patients still hope that some disease-specific treatment may be effective. (annals.org)
- Shared decision-making in end-stage renal disease: a protocol for a multi-center study of a communication intervention to improve end-of-life care for dialysis patients. (umassmed.edu)
- Overall, the majority of participants rejected notions of HF as a terminal illness in favour of a focus on day-to-day management and maintenance, despite obvious deterioration in disease stage and needs over time. (ovid.com)
- Although the disease happens to the patient, the family as a whole is also affected by a loved one with a terminal illness. (allcaringhospice.com)
- And because this is a progressive disease it means that the sufferer will require specialist care in the later stages. (medic8.com)
- Someone with a form of dementia, such as Alzheimer's disease will require 24 hour nursing care and these homes can provide that. (medic8.com)
- OT's) and (OTA's) are traditionally working in hospice care and emerging practice for Alzheimer Disease and Dementia patients to making a difference every day. (bartleby.com)
- With regards to end of life, the national cancer institute defines comfort care as care give to improve the quality of life of patient who has a serious or life threatening disease. (bartleby.com)
- Palliative care must therefore be integral to the clinical approach to the disease. (usakochan.net)
- it must cover not just the terminal phase, but support the patient and their family from the onset of the disease. (usakochan.net)
- Clear guidelines are provided to address care throughout the disease process. (usakochan.net)
- This session will provide a brief overview of the personal care needs, as well as communication with family for someone who is in the terminal phase of their disease. (ausmed.com.au)
- This has been particularly useful in cancer because it has encouraged the scrutiny of care delivered across the disease continuum and the establishment of practice guidelines (Morris, 1996). (nap.edu)
- Terminal illness is an incurable disease that cannot be adequately treated and is reasonably expected to result in the death of the patient within a short period of time. (wikipedia.org)
- Palliative care is normally offered to terminally ill patients, regardless of their overall disease management style, if it seems likely to help manage symptoms such as pain and improve quality of life. (wikipedia.org)
- While palliative care is not disease treatment, it addresses patients' physical needs, such as pain management, offers emotional support, caring for the patient psychologically and spiritually, and helps patients build support systems that can help them get through difficult times. (wikipedia.org)
- Palliative care is primarily focused on improving quality of life and relieving burdensome symptoms in all patients with terminal conditions, including those with cancer and non-cancer illness. (bmj.com)
- Inpatient hospice care facilities are available, if needed, should symptoms become too difficult to manage at home. (allcaringhospice.com)
- End-Of- Life Care addresses the many symptoms that patients experience in their last hours, days or weeks of life. (straitstimes.com)
- We help to assess and address these symptoms so that patients can be more comfortable in the place of care. (straitstimes.com)
- Control of symptoms is covered alongside the psychosocial care of patients and their families. (usakochan.net)
- At VITAS, we tailor our clinical care and our support services to meet the unique symptoms and social and emotional needs that can accompany each specific condition or illness. (vitas.com)
- Susan Miller, who specializes in hospice and palliative care at Brown University School of Public Health in Providence, Rhode Island but who was not involved with the current study, said for patients nearing the end of life, hospitals' palliative care teams "typically address management of symptoms such as pain and include discussion of goals of care including the choice of hospice. (reuters.com)
- The statement also provides practical information for clinicians, such as when to consider referral to hospice care and how to withdraw mechanical ventilation. (medicalxpress.com)
- It is intended as a resource to inform and assist clinicians who care for cancer patients. (oncolink.org)
- It provides guidance in the care of dying people and is aimed at all clinicians everywhere - hospital and community. (51digg.info)
- The book will doubtlessly be highly valued by palliative care clinicians for its practical and thorough overview of some of the most challenging clinical problems they face. (routledge.com)
- In the past 15 years, palliative care has emerged from near obscurity to become a board-certified medical specialty for physicians and a prominent part of contemporary healthcare for all providers and their patients. (medicalxpress.com)
- Professional competence and development of specific skills for healthcare providers who are involved in palliative care, especially the ability to communicate compassionately and effectively in order to help patients and/or family members make decisions about their care by determining treatment goals, developing appropriate strategies in line with those goals and preparing advance directives. (medicalxpress.com)
- This is a challenge for all of us, but doctors and healthcare professionals could also benefit from training and a greater understanding of the work that hospices do and what is available from palliative care. (parliament.uk)
- In the age of rising healthcare costs, some have questioned whether the primary benefits of palliative care can also translate into collateral reductions in healthcare use and its associated costs. (bmj.com)
- There is therefore an urgent need for high-quality studies that evaluate the ability of palliative care to relieve the high burden of suffering and healthcare use in patients with noncancer illness who have a very different trajectory of dying. (bmj.com)
- We were surprised to find an increased rate of healthcare use associated with palliative care in those dying from dementia, a finding that will require further study to explain. (bmj.com)
- Lack of awareness of the availability of palliative care or its benefits was not the fault of these patients or their healthcare providers. (bmj.com)
- But when I referred these patients to our palliative care teams who were well equipped to provide care for them at home and prevent unwanted transfers to the emergency department, I wondered, if palliative care can do it here, can they do it across an entire healthcare system? (bmj.com)
- As the evidence base for the benefits of palliative care expands, the next challenge facing healthcare systems is how to organize and disseminate sustainable care that aligns with the individual preferences of our patients, a goal set by the Institute for Healthcare Improvement in the United States. (bmj.com)
- To meet these enormous challenges, we need sustained investment in healthcare provider training and the scaling of existing effective models of collaborative palliative care, as well as research to evaluate its effectiveness. (bmj.com)
- Whatever your healthcare needs, our staff is here to welcome you and help ensure you receive the care you need to reach your optimum level of health and well-being. (lifepathhospicecare.com)
- Be sure to alert your healthcare provider about the wound so they can develop a plan to care for it properly. (verywellhealth.com)
- It is the first palliative care service in the private healthcare sector with full-time specialists in palliative medicine. (straitstimes.com)
- I believe it is high time the NMA begins to have an open mind as to how we can run the healthcare system in Nigeria in order to make it a patient-centered care. (thisdaylive.com)
- â€œIn 2017, healthcare professionals across the globe are more concerned about working together to deliver patient-centered care. (thisdaylive.com)
- Efuribe, who is a healthcare promotion ambassador on self care, wellness and better healthcare, said to build an efficient health service delivery system, all healthcare workersâ€™ salaries should be revised and harmonised so that people can be rewarded as well as gain some fulfillment for the services they offer, adding that the focus should not be relativity or superiority in my opinion. (thisdaylive.com)
- The author has drawn on his great experience in both consultation-liaison psychiatry and palliative medicine to produce an essential, evidence-based guide for all healthcare professionals involved in palliative care. (routledge.com)
- Caregiver support, custodial care, respite (for patients at home) etc. (geripal.org)
- Respite Care - Caring for a loved one who has a terminal illness can be overwhelming and exhausting. (allcaringhospice.com)
- Hospice care offers short term "respite" or relief care, up to five days, to allow the primary caregiver to rest, recharge or simply get a much-needed break. (allcaringhospice.com)
- Terminal cancer care and patients' preference for place of death: a prospective study. (bmj.com)
- Terminal cancer care. (bmj.com)
- Levy MH: Doctor-patient communication: the lifeline to comprehensive cancer care. (oncolink.org)
- Cancer care can also be emotionally taxing on the oncologists who must frequently give bad news and deal with dying and death. (oncolink.org)
- The Palliative Care Services in Parkway Cancer Centre (PCC) was set up in July 2008, as part of the centre's push to provide comprehensive cancer care programme for all our patients. (straitstimes.com)
- Question: With so many people affected by cancer, why is there so little information about the role of nutrition in cancer care? (huntsmancancer.org)
- The nutrition status of patients with cancer can vary at presentation and through the continuum of cancer care. (conehealth.com)
- Ask The Treatment Expert: Is a Kennedy Terminal Ulcer a pressure injury? (mcknights.com)
- A Kennedy Terminal Ulcer is a pressure injury that develops on residents as they are dying. (mcknights.com)
- A Kennedy Terminal Ulcer tends to have a sudden rapid onset, developing in a matter of hours. (mcknights.com)
- Treatment of a Kennedy Terminal Ulcer is the same as for any other pressure injury with the same characteristics. (mcknights.com)
- Hall, an 82-year-old former World War II prisoner of war who is serving a life sentence for murder, has spent nearly a decade in the infirmary at Iowa State Penitentiary with a terminal heart ailment. (go.com)
- [email protected] Studying end of life in dementia is challenging because of the frailty of the population, additional cognitive problems and difficulty of assessing when patients enter the terminal phase. (scribd.com)
- Quantitative studies, including observational studies which are frequently ethically appropriate, are helpful to increase the desired evidence base of effective treatment and Mobile phone end-of-life care in dementia patients. (scribd.com)
- Pain one's health, the palliative care concern the last period of a man's life, trying to give him back the largest possible self-sufficiency. (scribd.com)
- This is the first study focused on black/white differences that prospectively asked [terminal cancer patients] what kind of care they wanted at the end of life, and then documented the kind of care they actually received and the place of their death," said Elizabeth Trice, MD, PhD, of Dana-Farber, lead author. (emaxhealth.com)
- The article has important implications for how we approach and treat advanced dementia in the nursing home and hopefully will spur providers to provide care that reduces and avoids suffering and improves the quality of life of their patients. (geripal.org)
- He notes, "now some 30 years after my grandmother's death, end-of-life care for dementia does not look all that different from the treatment she received. (geripal.org)
- Hopefully, recognizing that end stage dementia is a terminal condition will result in improved care---care focused on the quality of life of patients and the needs of their families. (geripal.org)
- This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging & Health. (virtualhospice.ca)
- It explains what changes to expect when caring for a loved one at the end-of-life. (virtualhospice.ca)
- Palliative care needs to go hand in hand with hospital treatment and should be available for all people with advanced and progressive illnesses and life-shortening conditions. (parliament.uk)
- Sufferers should be able to plan ahead for their end-of-life care and ensure that their wishes are known. (parliament.uk)
- Research has shown that early referral for palliative care can improve the quality of life and lengthen it. (parliament.uk)
- We need to have properly funded nationwide palliative care provision that is integrated with local authorities, community care providers and local NHS providers, so that there is a comprehensive and coherent way of addressing end-of-life care. (parliament.uk)
- There is still a big taboo about talking about end-of-life care and there is limited understanding among the public about what palliative care is and when it is appropriate. (parliament.uk)
- In Japan, only a few hospitals play a role in home medical care including end-of-life care. (go.jp)
- Communication and planning for heart failure (HF) care near the end of life is known to be complex. (ovid.com)
- Overall however, there were positive associations between the number of physician visits and the recognition of the resident's terminal phase and between the number of physician visits and the resident having palliation as main treatment goal in the last week of life. (endoflifecare.be)
- The End-of-Life Care Research Group aims to conduct high-quality scientific research in end-of-life care in Belgium and Europe. (endoflifecare.be)
- The research group is spearheaded by a number of experienced researchers and strives to expand expertise in end-of-life care research. (endoflifecare.be)
- BACKGROUND Efforts to improve communication between physicians and dying patients have been unsuccessful, and guidelines for improving patient-physician communication about end-of-life care are based primarily on expert opinion. (semanticscholar.org)
- This study assessed which aspects of communication between patients and physicians are important in end-of-life care. (semanticscholar.org)
- What is wrong with end-of-life care? (semanticscholar.org)
- At All Caring Hospice, we understand that patients with life-limiting conditions or terminal illnesses have unique experiences. (allcaringhospice.com)
- Support with difficult decisions - Hospice care helps families make difficult decisions and choices that may impact their loved ones health and quality of life. (allcaringhospice.com)
- Many people with a terminal condition, or who have a loved one with a life-limiting illness, have heard of hospice care. (allcaringhospice.com)
- Practicing in the area of hospice, I am often faced with caring for patients at end of life. (bartleby.com)
- You may find the End of Life Care article more useful, or one of our other health articles . (51digg.info)
- A report from the National End of Life Care Intelligence Network compared people's preferences for place of death with actual place of death in England and reported that variations exist across the country and between conditions (69% of people with non-cancerous respiratory conditions die in hospital) [ 3 ] . (51digg.info)
- Five "Priorities of Care" are described and form the focus of care at the end of life. (51digg.info)
- Palliative medicine is the branch of medicine in palliative care, which aims to relieve suffering and improve the quality of life of patients who are facing life-threatening illnesses such as advanced cancers. (straitstimes.com)
- No, although terminal care or hospice care (which generally implies the medical care in the last few days or months of life) is an important part in palliative care. (straitstimes.com)
- Palliative Care Services may be involved with patients who are still receiving active cancer treatment such as chemotherapy or radiation therapy, and are not necessarily in their last days or months of life. (straitstimes.com)
- We provide four main categories of services: Cancer Pain Management, Discharge and Home Care Planning, Advance Care Planning, and End-of-Life Care. (straitstimes.com)
- 68-76% of the general population and medical practitioners expressed disapproval of life-extending medical treatment of terminal patients suffering pain. (fujita-hu.ac.jp)
- 5. Most medical practitioners felt that some medical treatments, such as bedsore care, should be continued in lieu of life support, but there were differences in opinion between practitioners at various types of medical facilities regarding the necessity of such specific measures as, for example, blood pressure monitoring by automatic sphygmomanometer among the medical facilities. (fujita-hu.ac.jp)
- CONCLUSION: Both the general population and the medical practitioners in Japan tended to oppose life-extending medical treatment for painful terminal cases and patients in a prolonged vegetable state. (fujita-hu.ac.jp)
- The current legal definition of 'terminal illness' is not in keeping with the definition of 'end of life' and lacks any clinical relevance. (pulsetoday.co.uk)
- Hospice care is a specific type of palliative care for patients in the last six months of life. (ohsu.edu)
- To receive hospice care, adults need to end life-prolonging treatment. (ohsu.edu)
- To evaluate, in patients with heart failure, the effect of a self-care promotion program using a multifaceted strategy in comparison to the usual care about acceptability to the application of SMS, patient and / or family satisfaction with care, quality of life scales health scales, self-care scales and knowledge on HF, visual analog scale of dyspnea, and clinical outcomes at 30 and 180 days. (clinicaltrials.gov)
- Reuters Health) - A new study adds to evidence that hospice care during the last six months of life is associated with better overall experiences for patients and a lower likelihood of dying in a hospital. (reuters.com)
- If someone is hospitalized and approaching the end of life, hospice care is more optimal so they can get the care they need," she told Reuters Health by phone. (reuters.com)
- end-of-life care is available through hospice and palliative care programs, there should be no reason anyone would need to seek PAS" (1). (majortests.com)
- After years of neglect, care at the end of life is receiving increasing attention and concern. (nap.edu)
- When the time is right, palliative and hospice care can offer wholistic end of life support and resources. (seniornavigator.org)
- Services related to end-of-life care prescribed for individuals, generally with 6 months or less to live, that can be provided in the home or in a facility. (seniornavigator.org)
- It's important to consider long term care and end-of-life care options. (seniornavigator.org)
- There is no standardized life expectancy for a patient to be considered terminal, although it is generally months or less. (wikipedia.org)
- Life expectancy for terminal patients is a rough estimate given by the physician based on previous data and does not always reflect true longevity. (wikipedia.org)
- Because terminal patients are aware of their oncoming deaths, they have more time to prepare advance care planning, such as advance directives and living wills, which have been shown to improve end-of-life care. (wikipedia.org)
- Palliative care can also help patients make decisions and come to understand what they want regarding their treatment goals and quality of life. (wikipedia.org)
- Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Norrköping. (diva-portal.org)
- Patients and main outcome measures NT-pro-BNP was collected from 481 consecutive patients on admission to intensive care, in addition to data on patient characteristics and outcome. (diva-portal.org)
- Conclusion: We conclude that NT-pro-BNP is commonly elevated on admission to intensive care, that it increases with severity of illness and that it is an independent predictor of mortality. (diva-portal.org)
- Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. (diva-portal.org)
- Objectives: To develop and implement a fully mobile computer terminal that interfaces with our computerized intensive care unit (ICU) local area network and order management system. (uab.edu)
- We provide services to families with a newborn in Doernbecher's Neonatal Intensive Care Unit. (ohsu.edu)
- Intensive care. (wikipedia.org)
- It cannot be right that palliative care funding is dependent on local clinical commissioning groups, whose contributions to local hospices' costs range as widely as 1% to 50% from region to region. (parliament.uk)
- This week is Children's Hospice Week, and the Rainbow Trust Children's Charity has identified that hospices save the NHS money by freeing up hospital beds, reducing the number of missed appointments and, in the case of children with terminal illnesses, helping parents stay together by allowing them to manage their feelings better in a supportive environment. (parliament.uk)
- MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow. (bmj.com)
- Data on the preferences was obtained from the Coping with Cancer study led by Holly Prigerson, PhD, director of the Center for Psycho-social Oncology and Palliative Care Research at Dana-Farber and an associate professor of psychiatry at Harvard Medical School. (emaxhealth.com)
- It's comprehensive and covers palliative care for children and adults, as well as for patients with pulmonary disorders or critical illnesses," said Paul N. Lanken, M.D., professor of medicine and medical ethics at the Hospital of the University of Pennsylvania and co-chair of the ATS task force that wrote the statement. (medicalxpress.com)
- Terminal Care" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Medical and nursing care of patients in the terminal stage of an illness. (umassmed.edu)
- We retrospectively investigated the clinical course and outcomes of 42 patients with cancer who had received home medical care provided by our hospital. (go.jp)
- This clinic comprises Hickman catheter or port care and is being run and managed by specially trained nursing staff and chemotherapy sisters, supervised by medical oncologists. (jaslokhospital.net)
- Dr. A R Fakih has treated several patients in India and gives every patient the best of medical care. (jaslokhospital.net)
- If you've reached a point where you need regular medical monitoring, we also provide long-term care in a homelike environment with plenty of activities to help nurture the body, mind and spirit. (lifepathhospicecare.com)
- Since 2013, for our efforts to integrate palliative care successfully into our cancer management in PCC, it has earned us the prestigious accreditation as an European Society for Medical Oncology (ESMO) Designated Centre of Integrated Oncology and Palliative Care. (straitstimes.com)
- Advance Care Planning is a new concept to help the patient to plan and document his wishes/preferences regarding his medical treatment in advance and to appoint a substitute decision maker in the event that he loses the mental capacity to do so later. (straitstimes.com)
- Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. (google.com)
- 5 . The system of claim 1 , wherein the patient-specific information comprises any of a patient identifier, a patient location, a patient care device location, patient age, a physical characteristic or a medical characteristic. (google.com)
- OBJECTIVES: Assessment of attitudes held by the general population and medical practitioners in Japan regarding medical interventions in cases of painful terminal illness or a prolonged vegetative state. (fujita-hu.ac.jp)
- There are some differences in opinion between the general population and practitioners at various types of medical facilities regarding the extent of desirable medical care in such circumstances. (fujita-hu.ac.jp)
- Kojima, M. / Attitudes towards terminal care among the general population and medical practitioners in Japan . (fujita-hu.ac.jp)
- Dr. Robert Macauley, our medical director, is a national expert in pediatric palliative care. (ohsu.edu)
- Decisions regarding management are made by the patient and his or her family, although medical professionals may give recommendations or more about the services available to terminal patients. (wikipedia.org)
- Evaluation and quality control of medical care. (wikipedia.org)
- Economics of medical care. (wikipedia.org)
- Employment RA411-415 Provisions for personal medical care. (wikipedia.org)
- Medical care plans RA418-418.5 Medicine and society. (wikipedia.org)
- community care provision required for home care. (bmj.com)
- Unfortunately, the provision of palliative care is patchy at best. (parliament.uk)
- Joint working will facilitate the recognition of a resident's terminal phase and the timely provision of palliative care. (endoflifecare.be)
- however, at least 63% of people express a preference to die at home and provision of palliative home care has been shown to be key to achieving this [ 6 ] . (51digg.info)
- Each may bring its own challenges in terms of the provision of terminal care. (51digg.info)
- Palliat Support Care. (umassmed.edu)
- Spiritual and emotional support - Hospice care helps meet the spiritual and emotional needs of not only the patient, but also their loved ones. (allcaringhospice.com)
- An individual plan of care, which includes food and drink, symptom control and psychological, social and spiritual support, is agreed, co-ordinated and delivered with compassion. (51digg.info)
- Psychological and family support is crucial in terminal illness. (everydayhealth.com)
- Hospice care offers symptom management, emotional and spiritual support, and it's a Medicare benefit," she said. (reuters.com)
- Hospice care, which can be provided at home or in a long-term care facility, additionally provides emotional and spiritual support for the patient and loved ones. (wikipedia.org)
- Comments on the Proposed Rule to Amend Various Aspects of Medicare re: Reimbursing Medicare Providers for Advance Care Planning Counseling Sessions Centers for Medicare & Medicaid Services Department of Health and Human Services Room 445-G Hubert H. Humphrey Building 200 Independence Avenue SW Washington, DC 20201 Attn: CMS-1625-P …we respectfully submit the following comments on the Proposed Rule to amend various aspects of the Medicare program. (physiciansforlife.org)