The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Regulatory sequences important for viral replication that are located on each end of the HIV genome. The LTR includes the HIV ENHANCER, promoter, and other sequences. Specific regions in the LTR include the negative regulatory element (NRE), NF-kappa B binding sites , Sp1 binding sites, TATA BOX, and trans-acting responsive element (TAR). The binding of both cellular and viral proteins to these regions regulates HIV transcription.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC
Medical and nursing care of patients in the terminal stage of an illness.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
The synapse between a neuron and a muscle.
Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)
Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
Established cell cultures that have the potential to propagate indefinitely.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.
The rate dynamics in chemical or physical systems.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Neurons which activate MUSCLE CELLS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Use of electric potential or currents to elicit biological responses.
The specialized postsynaptic region of a muscle cell. The motor endplate is immediately across the synaptic cleft from the presynaptic axon terminal. Among its anatomical specializations are junctional folds which harbor a high density of cholinergic receptors.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The sum of the weight of all the atoms in a molecule.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Common name for Carassius auratus, a type of carp (CARPS).
Proteins prepared by recombinant DNA technology.
The most common inhibitory neurotransmitter in the central nervous system.
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The functional hereditary units of VIRUSES.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Enzymes that catalyze the incorporation of deoxyribonucleotides into a chain of DNA. EC 2.7.7.-.
Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. Long terminal repeats (LTRs) similar to those from retroviruses are contained in retrotransposons and retrovirus-like elements. Retroposons, such as LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS do not contain LTRs.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A vesicular glutamate transporter protein that is predominately expressed in the DIENCEPHALON and lower brainstem regions of the CENTRAL NERVOUS SYSTEM.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.
Contractile tissue that produces movement in animals.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A vesicular glutamate transporter protein that is predominately expressed in TELENCEPHALON of the BRAIN.
The characteristic 3-dimensional shape of a carbohydrate.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Transport proteins that carry specific substances in the blood or across cell membranes.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Refers to animals in the period of time just after birth.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Deletion of sequences of nucleic acids from the genetic material of an individual.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
INTERNEURONS of the vertebrate RETINA containing two processes. They receive inputs from the RETINAL PHOTORECEPTOR CELLS and send outputs to the RETINAL GANGLION CELLS. The bipolar cells also make lateral connections in the retina with the RETINAL HORIZONTAL CELLS and with the AMACRINE CELLS.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Proteins found in any species of virus.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A superfamily of various freshwater CRUSTACEA, in the infraorder Astacidea, comprising the crayfish. Common genera include Astacus and Procambarus. Crayfish resemble lobsters, but are usually much smaller.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Persons with an incurable or irreversible illness at the end stage that will result in death within a short time. (From O'Leary et al., Lexikon: Dictionary of Health Care Terms, Organizations, and Acronyms for the Era of Reform, 1994, p780)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Ribonucleic acid that makes up the genetic material of viruses.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Neurotransmitter receptors located on or near presynaptic terminals or varicosities. Presynaptic receptors which bind transmitter molecules released by the terminal itself are termed AUTORECEPTORS.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
The relationships of groups of organisms as reflected by their genetic makeup.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
The production and release of substances such as NEUROTRANSMITTERS or HORMONES from nerve cells.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
The function of opposing or restraining the excitation of neurons or their target excitable cells.
Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Glycoproteins found on the membrane or surface of cells.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.
Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.
Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Actual loss of portion of a chromosome.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
The largest family of snakes, comprising five subfamilies: Colubrinae, Natricinae, Homalopsinae, Lycodontinae, and Xenodontinae. They show a great diversity of eating habits, some eating almost anything, others having a specialized diet. They can be oviparous, ovoviviparous, or viviparous. The majority of North American snakes are colubrines. Among the colubrids are king snakes, water moccasins, water snakes, and garter snakes. Some genera are poisonous. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp321-29)
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Slippery slopes in flat countries--a response. (1/1175)

In response to the paper by Keown and Jochemsen in which the latest empirical data concerning euthanasia and other end-of-life decisions in the Netherlands is discussed, this paper discusses three points. The use of euthanasia in cases in which palliative care was a viable alternative may be taken as proof of a slippery slope. However, it could also be interpreted as an indication of a shift towards more autonomy-based end-of-life decisions. The cases of non-voluntary euthanasia are a serious problem in the Netherlands and they are only rarely justifiable. However, they do not prove the existence of a slippery slope. Persuading the physician to bring euthanasia cases to the knowledge of the authorities is a problem of any euthanasia policy. The Dutch notification procedure has recently been changed to reduce the underreporting of cases. However, many questions remain.  (+info)

Conditions required for a law on active voluntary euthanasia: a survey of nurses' opinions in the Australian Capital Territory. (2/1175)

OBJECTIVES: To ascertain which conditions nurses believe should be in a law allowing active voluntary euthanasia (AVE). DESIGN: Survey questionnaire posted to registered nurses (RNs). SETTING: Australian Capital Territory (ACT) at the end of 1996, when active voluntary euthanasia was legal in the Northern Territory. SURVEY SAMPLE: A random sample of 2,000 RNs, representing 54 per cent of the RN population in the ACT. MAIN MEASURES: Two methods were used to look at nurses' opinions. The first involved four vignettes which varied in terms of critical characteristics of each patient who was requesting help to die. The respondents were asked if the law should be changed to allow any of these requests. There was also a checklist of conditions, most of which have commonly been included in Australian proposed laws on AVE. The respondents chose those which they believed should apply in a law on AVE. RESULTS: The response rate was 61%. Support for a change in the law to allow AVE was 38% for a young man with AIDS, 39% for an elderly man with early stage Alzheimer's disease, 44% for a young woman who had become quadriplegic and 71% for a middle-aged woman with metastases from breast cancer. The conditions most strongly supported in any future AVE law were: "second doctor's opinion", "cooling off period", "unbearable protracted suffering", "patient fully informed about illness and treatment" and "terminally ill". There was only minority support for "not suffering from treatable depression", "administer the fatal dose themselves" and "over a certain age". CONCLUSION: Given the lack of support for some conditions included in proposed AVE laws, there needs to be further debate about the conditions required in any future AVE bills.  (+info)

Use of resources and costs of palliative care with parenteral fluids and analgesics in the home setting for patients with end-stage cancer. (3/1175)

BACKGROUND: In 1992 a home care technology project was started in which infusion therapy in the home setting was made available for patients with end-stage cancer. Beside aspects of feasibility and quality of life the resource utilization and costs of this transition was studied. PATIENTS AND METHODS: We conducted a cost evaluation study, to determine the actual cost of managing patients with endstage cancer who require parenteral administration of fluid or analgesics in the home setting. A total of 128 patients were prospectively followed, with a detailed analysis of some aspects in a sample of 24 patients. RESULTS: The cost for each patient was found to be between $250.00 and $300.00 per day, half of which are for hospital charges, even with this active home care technology program. One-third of the costs can be attributed to primary health care activities, in particular those of the district nurses. A hypothetical control group (n = 25) was constructed based on current practice and chart review. Patients in this group would have cost around $750.00 per day. With a median treatment period of 16 days this means a saving of $8000.00 per patient. CONCLUSION: Our data suggest that significant savings can be obtained by implementing programs transferring palliative care technology to the home setting.  (+info)

The timing of do-not-resuscitate orders and hospital costs. (4/1175)

The relation between the timing of do-not-resuscitate (DNR) orders and the cost of medical care is not well understood. This prospective observational study compares hospital costs and length of stay of 265 terminally ill patients with admission DNR orders, delayed DNR orders (occurring after 24 hours), or no DNR orders (full code). Patients whose orders remained full code throughout a hospital stay had similar lengths of stay, total hospital costs, and daily costs as patients with admission DNR orders. Patients with delayed DNR orders, by contrast, had a greater mortality, longer length of stay, and higher total costs than full code or admission DNR patients, but similar daily costs. The causes of delay in DNR orders and the associated higher costs are a matter for future research.  (+info)

Do social factors affect where patients die: an analysis of 10 years of cancer deaths in England. (5/1175)

BACKGROUND: This study investigated whether indices of social deprivation were related to the proportion of cancer patients who died at home. METHODS: Data were derived from death registrations for all cancer deaths 1985-1994 in England. Two indices of deprivation (Underprivileged Area Score (UPA), or Jarman, and Townsend scores) were calculated for each electoral ward; 1991 Census data were used. The scores use combinations of variables, including the percentage in overcrowded homes, the percentage of elderly people living alone, the percentage of one-parent families, etc. A high score indicates more deprivation. The main outcome measures were the proportion (in five and ten year averages) of cancer deaths which occurred at home, calculated for every electoral ward (with populations usually ranging from 5000 to 11,000). Spearman rho was used to test for correlations between the proportion of cancer deaths at home and deprivation score. Electoral wards were categorized by deprivation score into three groups of equal size and analysed over 10 years. Multivariate analysis was used to determine the relative association of different patient based and electoral ward variables with cancer death at home. p < 0.05 (two-tailed) was taken as significant. RESULTS: There were over 1.3 million death registrations from cancer in the 10 years. The proportion who died at home was 0.27, in hospital 0.47, and other setting 0.26. There were wide variations (0.05-0.75) in the proportion of people who died at home in different electoral wards. Small inverse correlations were found between the percentage who died at home and the UPA (-0.35; p < 0.001) and Townsend (-0.26; p < 0.001) scores. The correlations were greatest in North Thames (-0.63, UPA) and smallest in West Midlands (-0.20, UPA). The proportion of home deaths for the different bands of deprivation were: 0.30 (low deprivation), 0.27 (middle deprivation) and 0.24 (high deprivation). Plotting the trends over 10 years suggests no change in this relationship. Multiple regression analysis predicted several ward and patient characteristics and accounted for 30 per cent of the variation. Increased age (patient variable), Jarman score and ethnic minorities (both ward variables) were associated with fewer patients dying at home. Being male and having cancer of the digestive organs were associated with home death. CONCLUSION: There are wide variations in the percentage of cancer deaths at home in different electoral wards. Social factors are inversely correlated with home cancer death, and may explain part of this variation. Home care in deprived areas may be especially difficult to achieve.  (+info)

Abandonment of terminally ill patients in the Byzantine era. An ancient tradition? (6/1175)

Our research on the texts of the Byzantine historians and chroniclers revealed an apparently curious phenomenon, namely, the abandonment of terminally ill emperors by their physicians when the latter realised that they could not offer any further treatment. This attitude tallies with the mentality of the ancient Greek physicians, who even in Hippocratic times thought the treatment and care of the terminally ill to be a challenge to nature and hubris to the gods. Nevertheless, it is a very curious attitude in the light of the concepts of the Christian Byzantine physicians who, according to the doctrines of the Christian religion, should have been imbued with the spirit of philanthropy and love for their fellowmen. The meticulous analysis of three examples of abandonment of Byzantine emperors, and especially that of Alexius I Comnenus, by their physicians reveals that this custom, following ancient pagan ethics, in those times took on a ritualised form without any significant or real content.  (+info)

The status of the do-not-resuscitate order in Chinese clinical trial patients in a cancer centre. (7/1175)

OBJECTIVE: To report and analyse the pattern of end-of-life decision making for terminal Chinese cancer patients. DESIGN: Retrospective descriptive study. SETTING: A cancer clinical trials unit in a large teaching hospital. PATIENTS: From April 1992 to August 1997, 177 consecutive deaths of cancer clinical trial patients were studied. MAIN MEASUREMENT: Basic demographic data, patient status at the time of signing a DNR consent, or at the moment of returning home to die are documented, and circumstances surrounding these events evaluated. RESULTS: DNR orders were written for 64.4% of patients. Patients in pain (odds ratio 0.45, 95% CI 0.22-0.89), especially if requiring opioid analgesia (odds ratio 0.40, 95% CI 0.21-0.77), were factors associated with a higher probability of such an order. Thirty-five patients were taken home to die, a more likely occurrence if the patient was over 75 years (odds ratio 0.12, 95% CI 0.04-0.34), had children (odds ratio 0.14, 95% CI 0.02-0.79), had Taiwanese as a first language (odds ratio 6.74, 95% CI 3.04-14.93), or was unable to intake orally (odds ratio 2.73, 95% CI 1.26-5.92). CPR was performed in 30 patients, none survived to discharge. CONCLUSIONS: DNR orders are instituted in a large proportion of dying Chinese cancer patients in a cancer centre, however, the order is seldom signed by the patient personally. This study also illustrates that as many as 20% of dying patients are taken home to die, in accordance with local custom.  (+info)

Edmonton Regional Palliative Care Program: impact on patterns of terminal cancer care. (8/1175)

The Edmonton Regional Palliative Care Program was established in July 1995 to measure the access of patients with terminal cancer to palliative care services, decrease the number of cancer-related deaths in acute care facilities and increase the participation of family physicians in the care of terminally ill patients. In this retrospective study the authors compared the pattern of care and site of deaths before establishment of the program (1992/93) and during its second year of operation (1996/97). Significantly more cancer-related deaths occurred in acute care facilities in 1992/93 than in 1996/97 (86% [1119/1304] v. 49% [633/1279]) (p < or = 0.001). The number of inpatient days decreased, from 24,566 in 1992/93 to 6960 in 1996/97. More cancer patients saw a palliative care consult team in 1996/97 than in 1992/93 (82% v. 22%). The shift from deaths in acute care facilities to palliative hospices suggests that the establishment of an integrated palliative care program has increased access of patients with terminal cancer to palliative care.  (+info)

End-of-Life Decision Making is an issue wrapped in controversy and contradictions for Canadians. Most people in this country want to die at home, but few do; most believe planning for dying is important and should be started while people are healthy, but almost no one does it. And while most Canadians support the decriminalization of voluntary euthanasia and assisted suicide, both remain illegal under the Criminal Code of Canada. Assisted dying is a critically important public policy issue, where opinion, practice and the law seem out of alignment. The Royal Society of Canada, a national organization of distinguished scholars, artists and scientists, believes the time has come for a national debate on end-of-life decision making. It commissioned us, a panel of six Canadian and international experts on bioethics, clinical medicine, health law and policy, and philosophy, to prepare this report-both to trigger a national conversation on end-of-life issues and contribute material for those ... - BUFFALO, N.Y. - A new study by researchers at the University at Buffalo provides a groundbreaking look at how advance care planning medical orders inform emergency medical service (EMS) providers experiences involving people with intellectual disabilities.. Most states in the U.S. have programs that allow terminally ill patients to document their end-of-life decisions. In New York, the Medical Orders for Life-Sustaining Treatment form (MOLST) allows individuals to document what measures health care providers, including EMS providers, should take near the end of a patients life.. Studies suggest that this approach to person-centered advance care planning can alleviate a dying patients pain and suffering, according Deborah Waldrop, a professor in the UB School of Social Work and an expert on end-of-life care. Yet little research on end-of-life decision-making has been done on the growing population of older Americans with intellectual disabilities, which the American ...
A 2017 study by researchers at the University at Buffalo and published in the Journal of Applied Research in Intellectual Disabilities provides a groundbreaking look at how advance care planning medical orders inform emergency medical service (EMS) providers experiences involving people with intellectual disabilities.. A release from the university explains that most states in the U.S. have programs that allow terminally ill patients to document their end-of-life decisions. In New York, the Medical Orders for Life-Sustaining Treatment form (MOLST) allows individuals to document what measures health care providers, including EMS providers, should take near the end of a patients life.. Studies suggest that this approach to person-centered advance care planning can alleviate a dying patients pain and suffering, according Deborah Waldrop, a professor in the UB School of Social Work and an expert on end-of-life care. Yet little research on end-of-life decision-making has been done on the growing ...
ACP has a number of resources available on end-of-life issues including refusal of life-sustaining treatment, advance care planning, and other end-of-life care issues. The Ethics Manual, Sixth Edition, as well as end-of-life-care consensus papers and patient education brochures provide guidance and support for physicians and their patients.
Cancer care imposes a significant burden on health systems globally with the year following diagnosis and last year of life being the most resource-intensive stages of care [1]. Relative to the evidence-base supporting clinical decision-making at the time of a cancer diagnosis, there is limited understanding about what constitutes quality end-of-life care [2-5]. Randomized trials of end-of-life treatments and services remain rare and likely to remain so for ethical and practical reasons [6-9]. Therefore, researchers need to utilize other methods and data to examine this important area of medical practice. Observational research on end-of-life care can enhance our understanding of patterns of care in real-world clinical settings and assist in establishing evidence to inform clinical practice, resource allocation and planning decisions.. Observational studies using linked health administrative datasets to explore patterns of end-of-life care have increased in recent years. The use of existing data ...
Results 57 completed questionnaires - 17 chest consultants, 28 chest registrars, 11 physiotherapists, and 1 nurse clinician. 23 (40%) initiated End-of-Life discussions in severe IPF frequently or very frequently, and 47 (84%) felt it was a very important or important part of their role, but 42% felt predicting prognosis in advanced IPF was difficult or very difficult. More consultants felt End-of-Life discussions were an important part of their role than registrars.. Several aspects of End-of-Life care were felt to be harder in severe IPF than advanced malignancy (Figure 1), although similar to advanced COPD. 22 (42%) referred patients with severe IPF to hospital palliative care services very frequently or frequently, and 19 (37%) to community palliative care very frequently or frequently. Less than 10% of all respondents felt they had significant training in initiating End-of-Life discussions, palliating symptoms, or services available. ...
TY - JOUR. T1 - Health care ethics and health law in the Dutch discussion on end-of-life decisions. T2 - A historical analysis of the dynamics and development of both disciplines. AU - Kater, Loes. AU - Houtepen, Rob. AU - De Vries, Raymond. AU - Widdershoven, Guy. PY - 2003/12/1. Y1 - 2003/12/1. N2 - Over the past three or four decades, the concept of medical ethics has changed from a limited set of standards to a broad field of debate and research. We define medical ethics as an arena of moral issues in medicine, rather than a specific discipline. This paper examines how the disciplines of health care ethics and health care law have developed and operated within this arena. Our framework highlights the aspects of jurisdiction (Abbott) and the assignment of responsibilities (Gusfield). This theoretical framework prompted us to study definitions and changing responsibilities in order to describe the development and interaction of health care ethics and health law. We have opted for the context ...
The field of pediatric palliative care is hindered by the lack of a well-defined, reliable, and valid method for measuring the quality of end-of-life care. The study purpose was to develop and test an instrument to measure mothers perspectives on the quality of care received before, at the time of, and following a childs death. In Phase 1, key components of quality end-of-life care for children were synthesized through a comprehensive review of research literature. These key components were validated in Phase 2 and then extended through focus groups with bereaved parents. In Phase 3, items were developed to assess structures, processes, and outcomes of quality end-of-life care then tested for content and face validity with health professionals. Cognitive testing was conducted through interviews with bereaved parents. In Phase 4, bereaved mothers were recruited through 10 childrens hospitals/hospices in Canada to complete the instrument, and psychometric testing was conducted. Following review of 67
For patients with advanced leukemia, access to high-quality end-of-life care appears to be reduced in those dependent on blood transfusions, according to a new study being presented during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta. The study associates this reduced access and consequent diminished use of hospice services with a reduced quality of end-of-life care for these patients.
UPMC and the Beckwith Institute support a new effort by the Institute for Healthcare Improvement (IHI) to help health care providers receive and respect patients wishes about end-of-life care.
TY - JOUR. T1 - Administrators perspectives on end-of-life care for cancer patients in Japanese long-term care facilities. AU - Fukahori, Hiroki. AU - Miyashita, Mitsunori. AU - Morita, Tatsuya. AU - Ichikawa, Takayuki. AU - Akizuki, Nobuya. AU - Akiyama, Miki. AU - Shirahige, Yutaka. AU - Eguchi, Kenji. PY - 2009/10. Y1 - 2009/10. N2 - The purpose of this study was to clarify administrators perspectives on availability of recommended strategies for end-of-life (EOL) care for cancer patients at long-term care (LTC) facilities in Japan. A cross-sectional survey was conducted with administrators at Japanese LTC facilities. Participants were surveyed about their facilities, reasons for hospitalization of cancer patients, and their perspectives on availability of and strategies for EOL care. The 97 responses were divided into medical facility (n∈=∈24) and non-medical facility (n∈=∈73) groups according to physician availability. The most frequent reasons for hospitalization were a sudden ...
Data from the 2004 National Nursing Home Survey (most recent available) sheds light on end-of-life (EOL) care in nursing homes. One in four residents began EOL care before being admitted to a nursing home. Nursing home residents receiving EOL care were older, more functionally and cognitively impaired, and more likely to have reported pain in…
BACKGROUND: Intensive care units (ICUs) focus on treatment for those who are critically ill and interventions to prolong life. Ethical issues arise when decisions have to be made regarding the withdrawal and withholding of life-sustaining treatment and the shift to comfort and palliative care. These issues are particularly challenging for nurses when there are varying degrees of uncertainty regarding prognosis. Little is known about nurses end-of-life (EoL) decision-making practice across cultures. OBJECTIVES: To understand nurses EoL decision-making practices in ICUs in different cultural contexts. DESIGN: We collected and analysed qualitative data using Grounded Theory. SETTINGS: Interviews were conducted with experienced ICU nurses in university or hospital premises in five countries: Brazil, England, Germany, Ireland and Palestine. PARTICIPANTS: Semi-structured interviews were conducted with 51 nurses (10 in Brazil, 9 in England, 10 in Germany, 10 in Ireland and 12 nurses in Palestine). ...
In 2000, Tuskegee Universitys Center for Bioethics in Research and Health Care conducted a roundtable discussion about African-American perspectives on end-of-life care in order to plan a national conference on the same topic.
On June 17, 2016, amendments to the Criminal Code came into force rendering medical assistance in dying (MAID) legal everywhere in Canada provided certain conditions are met.2 The Criminal Code now provides an exception to the criminal prohibition against assistance in dying for individuals who are eligible for health services funded by a government in Canada, who are at least 18 years of age and capable of making decisions about their health, have a grievous and irremediable medical condition, have made a voluntary request for MAID, and who provide informed consent. Individuals have a grievous and irremediable medical condition if they have a serious and incurable illness, disease or disability, are in an advanced state of irreversible decline in capability, and if their condition causes them enduring physical or psychological suffering that is intolerable to them and that cannot be relieved under conditions they consider acceptable. In addition, the medical condition must be such that the ...
TY - JOUR. T1 - Potential for response bias in family surveys about end-of-life care in the ICU. AU - Kross, Erin K.. AU - Engelberg, Ruth A.. AU - Shannon, Sarah E.. AU - Curtis, J. Randall. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Background: After-death surveys are an important source of information about the quality of end-of-life care, but response rates generally are low. Our goal was to understand the potential for nonresponse bias in survey studies of family members after a patients death in the hospital ICU by identifying differences in patient demographics and delivery of palliative care between patients whose families respond to a survey about end-of-life care and those whose families do not. Methods: We performed a cohort study of patients who died in the ICU at 14 hospitals. Surveys were mailed to family members 1 to 2 months after the patients death. Chart abstraction was completed on all patients, assessing demographic characteristics and previously validated indicators of ...
The conversation around how to deal with a late-stage illness is changing in the United States. According to new data from the Pew Research Center, a growing number of people in the United States are choosing to be significantly more aggressive in treating end-of-life illnesses. In fact, the study reports that the number of respondents who say a doctor should always do everything possible to save a life has doubled from 15 to 31 percent since 1990. Some 35 percent of adults said they would instruct their doctors to keep them alive, even if they were in significant pain or battling a disease with little chance of recovery. How, if at all, have your views changed? Why?. Everything you share will be read by journalists only, and your responses are confidential unless you tell us we may publish them.. ...
The author cites a recent JAMA Internal Medicine article on physician- and nursing- reported barriers to end-of-life decision making. The study found that surveyed clinicians identified patient and caregiver reluctance to discuss as well as patient and caregiver lack of understanding of these issues as their primary obstacles to successful discussion of end-of-life issues in an ICU setting; however...
In a large cohort of hematologic oncologists surveyed in the United States, standard end-of-life quality measures were highly acceptable, but unrealistic patient expectations are the greatest impediment to quality end-of-life care.
Terminally ill patients who request that physicians make decisions for them get more aggressive end-of-life treatment and interventions, according to a new study.
Because many elderly people are living with advanced heart failure, healthcare providers need to be ready to discuss end-of-life issues with them as early as possible and throughout their illness, res
The End-of-Life Care Research Group aims to conduct high-quality scientific research in end-of-life care in Belgium and Europe. The research group is spearheaded by a number of experienced researchers and strives to expand expertise in end-of-life care research.. ...
The amount spent on end-of-life care for cancer patients varies widely across the United States, and is largely influenced by doctor preferences, new research f
Additional qualification in professional pedagogics: practical cialis patent expiration mentoring is no minor matter To characterize how ICU physicians approach and manage conflict with surrogates regarding end-of-life decision-making. Age dependent regulation of bone-mass and renal function by the MEPE cialis generic ...
Introduction: Honest prognostication and information for patients are important parts of end-of-life care. This study examined whether an educational intervention could increase the proportion of patients who received information about the transition to end-of-life (ITEOL care).. Method: Two municipalities (in charge of nursing homes) and two hospitals were randomised to receive an interactive half-day course about ITEOL for physicians and nurses. The proportion of patients who received ITEOL was measured with data from the Swedish Register of Palliative Care (SRPC). Patients were only included if they died an expected death and maintained their ability to express their will until days or hours before their death. Four hospitals and four municipalities were assigned controls, matched by hospital size, population and proportion of patients receiving ITEOL at baseline.. Results: The proportion of patients in the intervention group who received ITEOL increased from 35.1% (during a 6-month period ...
Individuals with a terminal illness, and the caregivers in their families, face many challenging questions, and the health care they receive can vary widely. For practitioners and policymakers seeking to better understand end-of-life care concerns, RAND researchers address a range of pertinent topics, including quality of care, costs, patient preferences, pain management, best practices, treatment disparities, and access requirements.
Cedars-Sinai offers Spiritual Care Services to patients and their loved ones. Often during the course of serious illnesses, patients and their families and friends can be caught up in a bewildering schedule of medications, treatments, doctor visits, surgeries and tests. Sometimes end-of-life issues must be confronted. At Cedars-Sinai, we understand that healing involves the whole person - body, mind, spirit and soul.. Our chapel, located on the Plaza Level between the North and South Tower, is open to persons of all faiths 24 hours a day ...
Cancer patients in their last weeks of life may have end-of-life experiences, including dreams and visions. A study from researchers at a hospice found that these events are an important part of a patients dying process.
In partnership with community members, researchers at UAB created the first culturally based protocol for patients living with a serious illness or facing end-of-life care. In partnership with community members, research...
Leaving Well offers important resources to ensure every person in Utah has the opportunity to live well to the end of life by sharing the conversation about their values, making their wishes known and receiving the end-of-life care they desire.
Whats getting you through your last weeks of work?: Whats getting you through your last weeks of work? Im interested in all ideas.. emotion, goal setting, intrinsic rewards, etc. (N.B. you can stop reading here & comment if you dont want to read about me feeling sorry for myself) Im 31+1, with twins, 2nd pregnancy. Annnd Im done! I never said ...
Womens health Pregnancy question and answers about my period has been irregular for the last month am worried because i been under stress too in my last period only last for ah one in ah half can u pleass give me ah answer
t care, Manchin said during a panel last week. So, dont you think infrastructure is something that could bring us together?
NEW YORK (GenomeWeb News) - What were the articles that gained the most interest from GenomeWeb Daily News readers last week? Here are the top five:
I upped my NDT last week from 1 3/4 Mon,Wed,Sat and 1 1/2 the rest of the week to 1 3/4 every day as my TSH was high and my t3 and 4 low. After about 6 days on the higher daily dose I started to...
Last week was a shorter one with our editors enjoying the Fourth of July holiday. Though we had a few days off, we still were able to take a look at new hardw...
My son (4.5 years) breaks out in these spots. He has since he was 1. They seem to last weeks each time he breaks out. - Answered by a verified Pediatrician
You have started to think about what you would want for the end of your life, but where should you start? Fortunately, there are several resources to which you can refer to help you start your own conversation.
Professor Patrick Pullicino, a leading critic of the controversial Liverpool Care Pathway which was phased out in 2014, said the new replacement proposals mimic many of the LCP's key problems.
** Note: This kernel is end-of-life and will no more be maintained. There will be no LineageOS 15.1 or newer kernel be available anymore ** Hi all, this...
The Question: Looking back over the last month what has changed for you? or Looking back over the last month what have you been consistant with? or Do you feel you have accompli, team45666board
Expert-reviewed information summary about the preparation needed by health care providers, patients, and families for the transition to end-of-life care in advanced cancer.
Last week, unfortunately CTD could not make it to air live. Therefore last weeks show/subject will be tonights show. A very important show. Connecting the…
We havent anointed anybody the closer, so I dont know, GM Brian Cashman said last month. I know Robertson wants it. But well see how the winter shakes out and how the competition in spring training takes place.. Robertson said hes ready to fight for the closers role.. I definitely want the opportunity, he said. Everyone has to realize though that Im not Mo, so Im just going to be me. I felt like I learned as much as I could from Mo. I stuck to his side like glue last year. Hopefully some of it sunk in. Mos consistency is what sticks with me - on and off the field hes the same guy.. ...
Before I get to the card, Id like to share a bit of news with you all. This will be my last month with Wplus9. Ive truly enjoyed my time as part of the Wplus9 Design Team and working with the amazingly talented Dawn and the DT girls. But, Ive come to realized that change, even though I can be hard at times, can be a good thing. I hope now to focus more on my home and family and my own stamp designs through Papertrey Ink. But, I thank Dawn endlessly for seeing the potential in me from the beginning (over a year ago) and giving me this wonderful opportunity to grow ...
|img style=float: left; src= alt= width=94 height=84 /|After a fast-paced three months, round 1 of the HPC Experiment (also known as the Uber-Cloud Experiment) concluded last month, with more than 160 participating organizations and individuals from 25 countries, working together in 25 international teams. In this article we present their main findings, challenges, and their lessons learned.
Enjoy this mix filled with songs selected by our team during the last month. We will try to publish a mixtape a month, so just follow us. This is the track list:. One Life Stand by Hot Chip ...
Some records are yet to be added from vouchers which have been taken, and all are subject to review, but here it is - The Cullaloe 500 of 2014! I had hoped to complete this number by the end of the year, so who knows how it will end now. I will undoubtedly focus on groups that I have more of a direct interest in, and perhaps spend less time chasing than I have in the last month ...
Last month I told you that I was doing a Whole 30 -- some of you have been following along on Instagram where I mini-blogged the experience on a daily basis. The short story is that it didnt accomplish what I was hoping for, but Im still glad I did it, and food will never be…
Continuing a trend that emerged late last month, flu activity remains high across the United States but there are reports that the number of infections may be l
Terminal care. Dying 727-727.5..................................Medical personnel and the public. Physician and the public 728- ... Critical care. Intensive care. First aid 91-103.....................................Disease due to physical and chemical agents ... Economics of medical care. Employment 411-415.........................................Provisions for personal medical care. ... Maternal care. Prenatal care services 47.3-47.4.................................Genetic aspects 50-51 ...
151 - Failed - Child Care Facilities Financing Act Of 1990. 152 - Passed - School Facilities Bond Act of 1992 153 - Passed - ... Terminal Condition. 162 - Passed - Public Employees' Retirement Systems. 163 - Passed - Ends Taxation of Certain Food Products ... 214 - Failed - Health Care. Consumer Protection. Initiative Statute. 215 - Passed - Compassionate Use Act of 1996. Medical Use ... 216 - Failed - Health Care. Consumer Protection. Taxes on Corporate Restructuring. 217 - Failed - Top Income Tax Brackets. ...
Main cardholder lives in a care or residential home and receive the higher or middle rate of the care component Disability ... Having a terminal illness. Having a progressive degenerative condition. Having lost one or more limbs. Being an injured veteran ... Living in a care or residential home or hospital. Being a Blue Badge holder. Being profoundly or severely deaf. Having a visual ... Having a mental illness, learning difficulty or personality disorder recognised under the Mental Health (Care and Treatment) ( ...
1982 - Tietê Bus Terminal opens. 1983 - April: Economic unrest. 1985 - Delegacias de Defense da Mulher (women's police station ... 1990 - Center for Education and Development of Health Care Workers of São Paulo established. 1991 Line 2 (São Paulo Metro) ... Jabaquara Intermunicipal Terminal opens. 1979 Line 3 (São Paulo Metro) begins operating. Teatro Lira Paulistana inaugurated. ... Casa das Áfricas founded.[3] 2003 - Lapa Terminal opens. 2005 - E-Tower and Ibirapuera Auditorium built. 2006 May 2006 São ...
Relf, M. & Couldrick, A. & Parkes, Colin Murray (1996). Counselling in Terminal Care and Bereavement. British Psychological ... Parkes is a former chairman and now life president of the charity Cruse Bereavement Care. He acted as a consultant and adviser ... He also has served as an advisory editor on several journals concerned with hospice, palliative care, and bereavement, and has ... Meerabeau, Liz; Wright, Kerri (2011). "6". Long Term Conditions: Nursing Care and Management. Wiley Blackwell. Stein, Samuel; ...
Angelayalet (October 23, 2017). "Discussion in 'Natural Hair Care': My kitchen/nape hair is different from my crown". Lipstick ... ISBN 4-7700-1655-7. Khalifa, A. M. (2014-04-28). Terminal Rage. Mavenhill. ISBN 9781940387000. Jones, Linda (July 1, 2008). " ... J, Christina (June 19, 2015). "7 Ways to Care for Nape Hair". Black Hair Information. ...
She dies in Archi's arms on her birthday and leaves her child in his care. Baha feels Archi will never forget Kamalika and ... Kamalika is diagnosed with a terminal disease. She goes to Palashboni and donates her money to build a hospital there. ...
The terminal was designed loosely on the old Ocean Terminal in Southampton. Disney Cruise Line has negotiated with the Port ... duBois, Megan (November 12, 2020). "Disney Earnings: From Disney+ To Busy Theme Parks, Five Things You Should Care About". ... The Disney Cruise Line Terminal, or Port Canaveral's Cruise Terminal 8, is located in Port Canaveral in Cape Canaveral, Florida ... Disney Cruise Line operates the Disney Cruise Line Terminal (Terminal 8) in Port Canaveral, Florida. The cruise line has ...
Cancer and Terminal Illness Patient Health Care Act. H.R. 4684, 2007-12-13, originally H.R. 4265, 2000-04-13. Assists those ... Quality Health Care Coalition Act of 2009. H.R. 1493, 2009-03-12, originally H.R. 1247, 2003-03-12. Exempts health care ... Paul proposes that all government funding of medical care be eliminated (with the exception, perhaps, of care for veterans). ... Creates tax credit to medical care providers against income tax for uncompensated emergency medical care, and deduction to ...
She is caring for one of her brothers, dying from disease. She is in her twenties. She has been given the title of assistant ... He is very ill, with a terminal illness. Mma Silvia Potokwani: Matron of the orphan farm outside Gaborone. She is a most ... He is a lively boy, well-behaved like his sister, who has been caring for him since his birth. He and his sister are of the ... She aids in the care of the foster children, and has children of her own. Big Government Man: He seeks the aid of the No. 1 ...
Kreps, Daniel (2016-01-13). "Blowfly in Hospice Care With Terminal Liver Cancer". Rolling Stone. Retrieved 2016-01-17. ... Tom Bowker announced in a statement on the Blowfly Facebook page that Reid was suffering from terminal liver cancer and had ...
Lap 120: Jack Harden had a terminal crash. Lap 123: The differential on Bay Darnell's care developed some serious issues. Lap ... Lap 173: Fred Lorenzen had a terminal crash. Lap 174: A.J. Foyt had some engine issues which forced him out of the race. Lap ... Lap 9: Gordon Johncock had a terminal crash. Lap 10: Wendell Scott had some engine issues which forced him out of the race. Lap ... Lap 261: Mario Andretti had a terminal crash. Lap 277: Sam McQuagg's vehicle developed some problems with its suspension. ...
The dying Emma shows her love for her mother by entrusting her children to Aurora's care. After Emma's death, Garrett reappears ... Emma is diagnosed with cancer, which becomes terminal. Aurora stays by Emma's side through her treatment and hospitalization, ...
Weldon had his life shortened by "two hours" according to the prosecution when Martin gave him a terminal dose of painkillers. ... caring practitioner." "Dr Shipman used opiate drugs for himself. I am drugs free." "He killed for his own power and ... I merely kept patients asleep when they were in dire circumstances." "Dr Shipman chose patients who were not terminal. I only ...
The cations are bound to eight terminal N centers. All thallium compounds are poisonous and should be handled with care; avoid ...
Intensive care department Chung King-fai as Dom Cheung (張大偉; Cheung Tai-wai) Chief of staff of the Intensive care unit. He ... He later has terminal lung cancer and eventually dies. Hugo Wong as Jason Chow (周景臣; Chow Geng-san) A doctor who sees nurses as ... Andy Lau Tin-lung as Wong Kwok-lap (黃國立) A patient in the intensive care ward. Adam Ip as Wong Dai-hing (王大興) A vomiting ... Elaine Yiu as Sylvia To (杜羨花; To Sin-fa) - female age 35 A nurse in the Intensive Care unit. She was the new intern nurses ...
... sometimes accompanied by other end of life care experts, help seniors consider their own end of life care preferences and ... "Reporter, Northwestern Doctor Launch Website About Facing Terminal Illness". CBS Chicago. Retrieved 2015-11-18. "Winning the ... "Advance care planning among seniors of a diverse city". Journal of Clinical Oncology. ISSN 0732-183X. "Death and beer: ... He came into the care of Mulcahy, a medical oncologist at Northwestern Memorial Hospital in Chicago. Though Mulcahy always told ...
The terminal and bridging CO ligands interchange rapidly. In NbCl5, there are two bridging and eight terminal chloride ligands ... When describing coordination complexes care should be taken not to confuse μ with η ('eta'), which relates to hapticity. ... In the case of ZrCl 4, there are both terminal and doubly bridging chloride ligands. In rhodium(II) acetate, the four acetate ... Ligands that are not bridging are called terminal ligands. Virtually all ligands are known to bridge, with the exception of ...
Agathe, where she cares for him. Duddy is left to show the movies seven days a week while still trying to oversee movie ... Meanwhile, Uncle Benjy finds he has a terminal illness. He tries to mend fences with Duddy, but Duddy rebuffs his request that ...
Bortz, Katherine (2019-06-19). "PICU terminal cleaning fails to decontaminate air ducts, floors". Levine D, Spratt H, Rowin M ( ... to research on contamination in pediatric intensive care units. Levine spoke on this subject at the Association for ... June 2019). "Effectiveness of a Cleaning Protocol on Environmental Contamination in a Pediatric Intensive Care Unit". American ...
... retrieved 8 April 2015 Cares, Dubai. "Dubai Cares". Archived from the original on 15 May 2015. Retrieved 21 ... Dubai Airport new terminal built. Nakheel Properties headquartered in Dubai. Al Barsha area development and Dubai Marathon ... September: Dubai Cares charity founded. The initial fund-raising drive raises over Dhs1 billion. 2008 March: Dubai Culture & ... Airport Dubai International Terminal 3 built. 1,500 room Atlantis, The Palm hotel & resort launched with 1,000 fireworks. 2009 ...
In medicine, specifically in end-of-life care, palliative sedation (also known as terminal sedation, continuous deep sedation, ... "Terminal Sedation", The World Federation of Right to Die Societies. *Discussion Forum, European Association for Palliative Care ... A Living Will, made when competent, can, under UK law, give a directive that the patient refuses 'Palliative Care' or 'Terminal ... On the other hand, a 2009 survey of almost 4000 U.K. patients whose care had followed the Liverpool Care Pathway for the dying ...
The negative battery terminal is connected to the car's chassis.. The Hudson Motor Car Company was the first to use a ... "The Automotive Storage Battery Its Care and Repair". PowerStream. Archived from the original on April 4, 2016. ... Corrosion at the battery terminals can prevent a car from starting due to electrical resistance, which can be prevented by the ... Physical format: batteries are grouped by physical size, type and placement of the terminals, and mounting style.[10] ...
The coach care centre, which is undergoing construction, is yet to be completed. Construction of a sickline complex and two pit ... Kochuveli, the satellite terminal of Thiruvananthapuram, is also poised for growth, with the present six platforms and a total ... Kerala State Road Transport Corporation operates a low-floor AC feeder bus from Kochuveli terminal to Trivandrum city for the ... The eastern side has the satellite terminal from where the trains originating from Kochuveli operate and the old railway ...
He is sentenced to life imprisonment, while Piper is placed in foster care. Six months later, Jensen is transferred to Terminal ... Throughout the season, Terminal Island inmates battle each other in specially modified cars on a track cut into the grounds, ... One such prison is Terminal Island Penitentiary, whose warden, Claire Hennessey, earns profits from broadcasting "Death Race", ...
Marie Curie Cancer Care Nurses; St John's Ambulance. Hecht's awards include the Specsavers National Book Awards 2001 Lifetime ... Rapid Effective Assistance for Children with Potentially Terminal illness; Alzheimer's Society "Singing for the Brain" groups; ... Action for Blind People; InterAct Reading Service; Mildmay Mission Hospital; Dementia Care; Resource: The Jewish Employment ...
"Quality care close to home for residents of Vaughan" (Press release). Ontario Ministry of Health and Long-Term Care. October 25 ... The transit terminal is used for services by York Region Transit (including Viva Silver), GO Transit, and other operators. A ... Other services include: surgical services and operating rooms diagnostic imaging ambulatory clinics intensive care acute care ... "YRT/Viva Transit Terminal adjacent to Mackenzie Vaughan Hospital" (PDF). City of Vaughan. October 1, 2015. Retrieved April 13, ...
After a fall, Fischer was belatedly diagnosed with terminal cancer. Goldberg helped care for him and managed to persuade the ... When Fischer became very ill in 1974, Goldberg kept a detailed diary of his medical care. The diary was subsequently smuggled ...
The new terminal is also equipped with two jet bridges. The 20,000 square metres (220,000 sq ft) apron can park 6 narrow-body ... Each departure hall is equipped with a baby care room, as well as an isolation room and emergency rescue hallway. ... The new terminal has 4 escalators, 5 elevators and a moving walkway. There are more than 1,000 waiting seats in the 3 waiting ... On April 17, 2014, the 20,000 square metres (220,000 sq ft) new terminal was officially opened. It has also expanded an apron ...
Local 3 - Butler City/Clearview Mall/BHS/Care Center/Terminal. Local 5 - Butler City/Duffy RD. VA Health Center/Butler Commons/ ... Local 3 - Butler City/Clearview Mall/BHS/Care Center/Terminal. Commuter service consists of 4 routes running from Butler to ... Weekday Routes and Major Destinations: Local 1 - Butler City/Pullman Square/Moraine Point/VA Hospital/Butler Commons/Terminal. ... Local 2/4 - Butler City/Butler Arbors/Sunnyview/BC3/Center Avenue/Terminal. ...
Protease inhibitors changed the nature of AIDS from a terminal illness to a somewhat manageable one. It significantly increased ... They sold it to Stadtalnder's Pharmacy and limited quantities to Veteran Administration's hospitals and some managed-care ...
al.], edited by Roger Jones ... [et (2004). Oxford textbook of primary medical care (repr. ed.). Oxford: Oxford University ...
"American Journal of Respiratory and Critical Care Medicine. 163 (3 Pt 2): S18-21. doi:10.1164/ajrccm.163.supplement_1.2011113. ... with an amidation at the C-terminus.[4] Substance P is released from the terminals of specific sensory nerves. It is found in ... When the innervation to substance P nerve terminals is lost, post-synaptic cells compensate for the loss of adequate ... Supportive Care in Cancer. 9 (5): 350-4. doi:10.1007/s005200000199. PMID 11497388.. ...
Here she guards and cares for them for about five months (160 days) until they hatch.[56] In colder waters, such as those off ... from the terminal organ of the reproductive tract (the cephalopod "penis") into the female's mantle cavity.[55] The ... Young octopuses learn nothing from their parents, as adults provide no parental care beyond tending to their eggs until the ... The female deposits fertilised eggs in a den and cares for them until they hatch, after which she also dies. ...
Some primary care providers may also take care of hospitalized patients and deliver babies in a secondary care setting. ... modern branch of clinical medicine that deals with pain and symptom relief and emotional support in patients with terminal ... Urgent care focuses on delivery of unscheduled, walk-in care outside of the hospital emergency department for injuries and ... See also: Health care, clinic, hospital, and hospice. Provision of medical care is classified into primary, secondary, and ...
The majority of BA services operate from Terminal 5, with the exception of some flights at Terminal 3 owing to insufficient ... ", "We'll Take More Care of You", and "Fly the Flag".[129] ... The exclusive 'Concorde Room' lounges at Heathrow Terminal 5 ... British Airways' promotional banner above the check-in desks at Heathrow Airport's Terminal 5. ... capacity at Terminal 5. In August 2014, Willie Walsh advised the airline would continue to use flight paths over Iraq despite ...
In addition, such laws may reduce health care costs,[3] improve work productivity, and lower the overall cost of labour in the ... For passenger terminals of airports, ferry ports and seaports which are listed in the Act. ... In Scotland, Andy Kerr, the Minister for Health and Community Care, introduced a ban on smoking in public areas on 26 March ... The Tobacco Regulation Act also prohibits smoking in public places, like schools, public transportation terminals, malls, and ...
The alkali metals and their hydrides react with acidic hydrocarbons, for example cyclopentadienes and terminal alkynes, to give ... The alkali metals also react with water to form strongly alkaline hydroxides and thus should be handled with great care. The ... The aggregates are held together by delocalised covalent bonds between lithium and the terminal carbon of the butyl chain.[139] ...
"2016-2018 Community Health Assessment and Community Health Improvement Plan: Take Care New York 2020" (PDF). New York ... At the northern edge of what is now East New York, a chain of hills, geologically a terminal moraine, separates northwestern ...
Secondary tumors of the brain are very common in the terminal phases of patients with an incurable metastasized cancer; the ... "Supportive Care In Cancer.. ...
N-Terminal domain antagonistsEdit. N-Terminal domain AR antagonists are a new type of AR antagonist that, unlike all currently ... Bockting W, Coleman E, De Cuypere G (2011). "Care of transsexual persons". N. Engl. J. Med. 364 (26): 2559-60; author reply ... Phyllis Carolyn Leppert; Jeffrey F. Peipert (2004). Primary Care for Women. Lippincott Williams & Wilkins. pp. 277-. ISBN 978-0 ... Vance SR, Ehrensaft D, Rosenthal SM (2014). "Psychological and medical care of gender nonconforming youth". Pediatrics. 134 (6 ...
Distributors must be able to demonstrate to national authorities that they have acted with due care and they must have ... telecommunications terminal equipment), 92/42/EEC (new hot-water boilers fired with liquid or gaseous fuels) and 73/23/EEC ( ... telecommunications terminal equipment), 92/42/EEC (new hot-water boilers fired with liquid or gaseous fuels), 93/42/EEC ( ...
Care of the Critically Ill Surgical Patient(英語:Care of the Critically Ill Surgical Patient) (CCrISP) ... 軸突終末(英語:Axon terminal). 突觸間隙(英語:Synaptic cleft) ... Acute Care of at-Risk Newborns(英語:Acute Care of at-Risk Newborns) (ACoRN) ... Nancy caroline's emergency care in the streets. 7. [S.l.]: Jones And Bartlett Learning. 2012: 557 [2016-03-19]. ISBN ...
"What Are the Public Switched Telephone Networks, 'PSTN' and Why You Should Care?". HuffPost. Archived from the original on 13 ...
"ELLIS ISLAND ENDS ALIEN PROCESSING; Last Detained Person Leaves -- 20,000,000 Immigrants Cared For in 62 Years". The New York ... The laundry-hospital outbuilding is south of the ferry terminal, and was constructed in 1900-1901 along with the now-demolished ... its Contract Hospital relationship with the Health Department of New York and Long Island College Hospitals who had been caring ...
Palliative care[edit]. Palliative care specialists state that many requests for euthanasia arise from fear of physical or ... On 1 August 2014, after euthanasia advocate Max Bromson, 66,[46] who suffered from terminal bone cancer, ended his life with ... "We have too many people who have the best palliative care in the world and they still want to know that they can put an end to ... Nitschke had encouraged Crick to enter palliative care, which she did for a number of days before returning home again. She had ...
Nurturant maternal care, in turn, may enhance HPA functioning in at least two ways. First, maternal care is crucial in ... CRH and vasopressin are released from neurosecretory nerve terminals at the median eminence. CRH is transported to the anterior ... Thus, if a developing child (i.e., fetus to neonate) is exposed to ongoing maternal stress and low levels of maternal care (i.e ... Whereas maternal care improves cardiac response, sleep/wake rhythm, and growth hormone secretion in the neonate, it also ...
Good skin care is also important in patients with hyper IgE syndrome. High-dose intravenous gamma-globulin has also been ...
... leaving them in the care of resident merchants. The trading post at Grand Bassam in Ivory Coast was left in the care of a ... The southern terminals of the trans-Saharan trade routes were located on the edge of the desert, and from there supplemental ... The more important terminals-Djenné, Gao, and Timbuctu-grew into major commercial centres around which the great Sudanic ...
He accused the company of not providing him with medical care while he was recuperating from his on-the-job injury and then not ... usually assigned to passenger terminals were painted in various combinations with red cab roof and cab doors, pale silver ...
2001). Applied health research manual: anthropology of health and health care (3rd ed.). Amsterdam: Het Spinhuis. ISBN ... However, instead of reaching a terminal market after the regional forwarding centres, the produce will reach an export market ... They are then moved to terminal markets such as in New Delhi, Kochi, and Bombay.[32] ...
... and involved with terminal care research and engaged with international universities. She is best known for her role in the ... Hartley, Nigel (21 November 2013). End of Life Care. ISBN 9780857003362. .. *^ Hartley, Nigel; Payne, Malcolm (15 May 2008). ... The work of the arts team is reflected in two publications: End of Life Care: A Guide for Therapists, Artists and Arts ... The Care of the Dying Patient and His Family; documentation in Medical Ethics, no. 5 (1975), published by the London Medical ...
... it was the cable used to connect IBM 3270 terminals to IBM 3274/3174 terminal cluster controllers). Later, some manufacturers ... and special care must be taken to prevent corrosion. With a flange connector it is also possible to go from rigid line to hard ...
The City that Care Forgot has been used since at least 1938,[21] and refers to the outwardly easy-going, carefree nature of the ... The New Orleans Union Passenger Terminal is the central rail depot and is served by the Crescent, operating between New Orleans ... This same terminal also serves the Canal Street/Gretna Ferry, connecting Gretna, Louisiana for pedestrians and bicyclists only ... Metropolitan New Orleans is a major regional hub for the health care industry and boasts a small, globally competitive ...
P24 - package insert - palliative - palliative care - pancreas - pancreatitis - pancytopenia - pandemic - pap smear - papilloma ... long terminal repeat sequence (LTR) - long-term nonprogressors - LTR - lumbar - lumbar puncture - lymph - lymph nodes - ... HAART - hairy leukoplakia - half-life - HAM/TSP - Health Care Financing Administration (HCFA) - Health Resources and Services ... New York Cares - NIAID - NICHD - night sweat - NIH - NK cell - NLM - NNRTI - non-Hodgkin's lymphoma (NHL) - non-nucleoside ...
Though one passenger was killed during the explosion, they took care of the injured passengers. ... Social Movements and the Transformation of American Health Care. Oxford University Press. p. 294. ISBN 978-0-19-974214-1. .. ... and health care than the general population which could affect overall health and cancer risk.[60] ...
What have we learned from experimental animal models? Crit Care Clin. 2:455-70. Uchida T, Makita K. (2008) Acute lung injury ... Bronchiolitis obliterans with organized pneumonia can ensue when granulation tissue accumulates in the terminal airways and ... Am J Respir Crit Care Med. 168:568-74. Matalon S, Maull EA. (2010) Understanding and treating chlorine-induced lung injury. ...
The US$11.1 billion East Side Access project, which will bring LIRR trains to Grand Central Terminal in Manhattan, is under ... with occupations spread relatively evenly across the health care, retail trade, manufacturing, construction, transportation, ... The midsection of Queens is crossed by the Long Island straddling terminal moraine created by the Wisconsin Glacier. The ... Originally opened in 1939, the airport's two runways and four terminals cover 680 acres (280 ha), serving 28.4 million ...
For severe TBI (i.e. those TBI patients in neurointensive care unit), the biofluid type where the biomarker can be detected ... Neuronal cell body injury markers include Neuron-specific enolase (NSE), Ubiquitin C-terminal hydrolase-L1 (UCH-L1), Astroglial ... whether it is for monitoring severe TBI patients in the intensive care unit, or triaging mild and moderate TBI patients in the ...
Infant care by the mother is relatively prolonged compared to many other mammals, and in some cases, the infants cling to the ... " ("Nostrils terminal and winding").[7]. When British zoologist Reginald Innes Pocock revived Strepsirrhini and defined ...
Prison Terminal: Kidnappers Care for Murderers at End of Life. * By Susan Donaldson James ... "Prison Terminal" will have its world premiere at the Irvine International Film Festival in California. Oscar nominations come ... Sales answers critics who say those who have committed violent crimes dont deserve compassion: "We have to be better at caring ... His unlikely comforters -- kidnappers and murderers -- are paid nothing for their hours of care-giving to a growing population ...
Last year we cared for over 40,000 people across the UK. ... We provide care and support for people living with any terminal ... Hospice care. Our nine hospices give round-the-clock, expert care and support to people living with a terminal illness - ... 5 a month - over a year, your gift could pay for three hours of vital nursing care for someone with a terminal illness in their ... Marie Curie Nurses give care and support to people living with a terminal illness in their own homes. ...
Antea Worldwide Palliative Care ConferenceRome, 12-14 November 2008 ABSTRACT FORM Presenting author ... ... Palliative care for cancer patients • Palliative care for non cancer patients • Paediatric palliative care • Palliative care ... Session: Training & Research in palliative care palliative care policies Chair: Dott. Franco Toscani and law • Palliative care ... Volunteering in palliative care . • Rehabilitation in palliative care • Palliative care quality indicators • Neurology in ...
Terminal cancer care and patients preference for place of death: a prospective study. British Medical Journal 1990; 301 :415 ... Terminal cancer care and patients preference for place of death: a prospective study.. British Medical Journal 1990; 301 doi: ... Terminal cancer care and patients preference for place of death: a prospective study. ... Terminal cancer care and patients preference for place of death: a prospective study. ...
Alivio de los síntomas en el enfermo terminal  World Health Organization (‎Ginebra : Organización Mundial de la Salud, 1999 ...
Antea Worldwide Palliative Care ConferenceRome, 12-14 November 2008 ABSTRACT FORM Presenting author ... ... palliative care policies and law • Palliative care: from villages to metropolies • Space, light and gardens for the Session: ... Palliative care for the elderly approach. • The actors of palliative care It will be necessary to train physiotherapists ... Volunteering in palliative care • Rehabilitation in palliative care . • Workshop on core curricula ...
The solid facts : palliative care / edited by Elizabeth Davies and Irene J. Higginson  ... Browsing Technical documents by Subject "Terminal Care". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V ...
... what kind of care they wanted at the end of life, and then documented the kind of care they actually received and the place of ... or advance care planning, when taking into account the patients own preference for more-aggressive care. It was clear that a ... Black patients with advanced cancer were more likely than whites to die in a hospital intensive care unit, reflecting a greater ... "This is the first study focused on black/white differences that prospectively asked [terminal cancer patients] ...
Term details for terminal illness. Broader terms. physical illness Related terms. death, end of life care, hospices, ... Social Care Online continues to be developed in response to user feedback. ...
... but now it is considered an integral part of the care that should be available to patients with serious respiratory ... ... Palliative care was once reserved for patients when all curative options had been exhausted and death was imminent, ... Beyond the terminal: Palliative care. April 15, 2008 Palliative care was once reserved for patients when all curative options ... Palliative care barriers must be addressed for heart/stroke patients. August 9, 2016 A new policy statement on palliative care ...
The AMA Code of Medical Ethics provides additional guidance on end-of-life care, such as Chapter 5, "Opinions on Caring for ... How to ease a terminal patients stress with earlier end-of-life care talks. ... Connect with the rest of the care team. "The conversations should be documented, accessible and flagged in the EMR to increase ... Typically, end-of-life care conversations take place in the last month of a patients life, in unfamiliar settings and with ...
... in the Oxford Textbook of Palliative Care (p. 407): "The goal of palliative terminal sedation is to provide the dying patient ... Terminal Sedation Or Palliative Sedation?. Dr Paulina Taboada. Profesor Centro de Bioetica. Pontificia Universidad Catolica de ... Tännsjö T (ed): Terminal sedation: Euthanasia in Disguise? Kluwer, Dodrecht, 2004). In an attempt to shed light on this debate ... The debate on "terminal sedation" still continues around the world. While some consider this praxis as normal medical treatment ...
Clinical Care of the Terminal Cancer Patient.. Ann Intern Med. 1983;99:428. doi: 10.7326/0003-4819-99-3-428_2 ... The care of patients with neoplastic diseases is often approached as though one is changing gears in a car: the treatment gear ... Care of the Adult Cancer Survivor Annals of Internal Medicine; 158 (11): ITC6-1 ... In many sections this book suffers from this problem, presuming that there are patients with terminal and nonterminal cancer. ...
This book provides a critique of the theoretical concept of caring, carers, and caregivers. The material is based on empirical ... This new evidence is used to make suggestions about possible ways forward within health and social care practice. ... or emotional care to others already known to them by virtue of kinship, co-habitation, or friendship, rather than carers ... are an invaluable free resource and there is an increasing amount of research into their role and the experiences of caring for ...
Initiation of palliative care. The primary exposure was a patients first encounter with palliative care across all care ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ... Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based ...
Your Name) has forwarded a page to you from Diabetes Care Message Body (Your Name) thought you would like to see this page from ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ... NH2-Terminal Probrain Natriuretic Peptide Is Associated With Diabetes Complications in the EURODIAB Prospective Complications ...
Your Name) has forwarded a page to you from Diabetes Care Message Body (Your Name) thought you would like to see this page from ... N-terminal pro brain natriuretic peptide reflects long-term complications in type 1 diabetes. Scand J Clin Lab Invest 2010;70: ... Plasma N-terminal pro-brain natriuretic peptide in Type 1 diabetic patients with and without diabetic nephropathy. Diabet Med ... N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in ...
Hopefully, recognizing that end stage dementia is a terminal condition will result in improved care---care focused on the ... "Were not talking about aggressive care versus no care," he said. "Palliative care is aggressive and attentive and focused on ... As a registered nurse, I find that palliative care medicine is one of the most intimate, most caring and beautiful forms of ... We invite the brightest minds in geriatrics, hospice, and palliative care to talk about the topics that you care most about, ...
Hopefully, recognizing that end stage dementia is a terminal condition will result in improved care---care focused on the ... "Were not talking about aggressive care versus no care," he said. "Palliative care is aggressive and attentive and focused on ... As a registered nurse, I find that palliative care medicine is one of the most intimate, most caring and beautiful forms of ... the difficulty obtaining hospice when the family wants both palliative care and traditional disease focused care and (2) the ...
Comfort measures and terminal extubation may be among the most important procedures you perform during a shift. ... Providing palliation and end-of-life care has become an important aspect of emergency medicine; this has become especially ... Palliative Care, COVID-19 Terminal Extubation in the ED: Palliative Care in EM. 8/17/2020 Marc Cassone, DO , Garrett Stoltzfus ... Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College of Critical Care ...
It explains what changes to expect when caring for a loved one at the end-of-life. ... This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging ... Caring for someone with a terminal illness: what to expect. Author(s): Lakehead University- Centre for Education and Aging ... This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging ...
"Terminal Care" by people in this website by year, and whether "Terminal Care" was a major or minor topic of these publications ... "Terminal Care" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Medical and nursing care of patients in the terminal stage of an illness. ... Below are the most recent publications written about "Terminal Care" by people in Profiles. ...
A Kennedy Terminal Ulcer is a pressure injury that develops on residents ... Is a Kennedy Terminal Ulcer a pressure injury? What are the main characteristics? ... A Kennedy Terminal Ulcer is a pressure injury that develops on residents as they are dying. The skin is the largest organ. Thus ... A Kennedy Terminal Ulcer tends to have a sudden rapid onset, developing in a matter of hours. Clinicians have reported the ...
Care for any terminal illness - Davids story. David Bevins, 66, of Harrogate, has been living with Chronic Obstructive ... Harrogate District Hospice Care is known locally as Saint Michaels Hospice.. Registered Charity No. 518905 Company No. 2121179 ... One in five of our patients is cared for thanks to a gift left in a will. ... One in every two people is touched by hospice care, which makes what we do very relevant. ...
Even those with a terminal illness are not being identified as in need of referral for palliative care. In some regions, one in ... That leave be given to bring in a Bill to require the provision of comprehensive palliative care to those with terminal ... At a time when there is chronic underfunding in social care, there is a serious lack of high-quality community care and support ... We need to have properly funded nationwide palliative care provision that is integrated with local authorities, community care ...
by APFLI , Jun 15, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 29, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 16, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 16, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ...
A retrospective study on clinical course and outcomes in patients with terminal cancer receiving home medical care provided by ... In Japan, only a few hospitals play a role in home medical care including end-of-life care. We retrospectively investigated the ... not wanting to die at home when beginning home medical care , Commitment of hospitals to provide back-up beds could contribute ... who complained of the difficulty in continuing home care owing to family caregiving burden. Significant factors not to die at ...
Kieran Quinn: We need to raise awareness of the benefits of palliative care services for patients with terminal non cancer ... But when I referred these patients to our palliative care teams who were well equipped to provide care for them at home and ... After all, many palliative care programmes were established in cancer centres to care for patients with cancer. ... Palliative care in patients with heart failure. BMJ 2016;353:i1010.. 9 Steinhauser KE, Arnold RM, Olsen MK, et al. Comparing ...
Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. A prospective ... Context: Amino-terminal pro-brain-type natriuretic peptide is known to predict outcome in patients with heart failure, but its ... Anesthesiology and Intensive Care Cardiac and Cardiovascular Systems Clinical Medicine Identifiers. urn:nbn:se:liu:diva-122759 ... role in an intensive care setting is not yet fully established. Objective: To assess the incidence of elevated amino-terminal ...
How Will Hospice Care Change?. by APFLI , May 12, 2010 , Treatment Concerns - Definitions / Living Wills / Palliative Care / ... by APFLI , May 13, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 13, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ... by APFLI , May 10, 2015 , Treatment Concerns - Definitions / Living Wills / Palliative Care / Terminal or Excessive Sedation / ...
  • Every pound you donate supports people living with a terminal illness. (
  • 5 a month - over a year, your gift could pay for three hours of vital nursing care for someone with a terminal illness in their home. (
  • The editorial , published in JAMA Oncology , is based on studies that looked separately at 278 patients and 91 clinicians who participated in the Serious Illness Care Program (SICP), at the Dana-Farber Cancer Institute and two affiliated satellite clinics, over nearly four years. (
  • Objective To measure the associations between newly initiated palliative care in the last six months of life, healthcare use, and location of death in adults dying from non-cancer illness, and to compare these associations with those in adults who die from cancer at a population level. (
  • Participants 113 540 adults dying from cancer and non-cancer illness who were given newly initiated physician delivered palliative care in the last six months of life administered across all healthcare settings. (
  • Medical and nursing care of patients in the terminal stage of an illness. (
  • As the population grows older and lives longer, many will develop health conditions that could become a terminal illness. (
  • Even those with a terminal illness are not being identified as in need of referral for palliative care. (
  • Palliative care is primarily focused on improving quality of life and relieving burdensome symptoms in all patients with terminal conditions, including those with cancer and non-cancer illness. (
  • 9] There is therefore an urgent need for high-quality studies that evaluate the ability of palliative care to relieve the high burden of suffering and healthcare use in patients with noncancer illness who have a very different trajectory of dying. (
  • The impetus for our study was inspired by my experiences caring for patients with noncancer illness such as heart failure, chronic obstructive pulmonary disease and dementia. (
  • Conclusion: We conclude that NT-pro-BNP is commonly elevated on admission to intensive care, that it increases with severity of illness and that it is an independent predictor of mortality. (
  • bereavement, People s Experiences, what is a terminal illness. (
  • Should heart failure be regarded as a terminal illness requiring palliative care? (
  • Overall, the majority of participants rejected notions of HF as a terminal illness in favour of a focus on day-to-day management and maintenance, despite obvious deterioration in disease stage and needs over time. (
  • Findings raise questions regarding the pragmatic utility of the concept of HF as a terminal illness and have implications for future HF care pathway development. (
  • Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is reasonably expected to result in the death of the patient. (
  • Each team member is experienced and trained in guiding patients and their loved ones through one of the most challenging parts of having a terminal illness. (
  • Although the disease happens to the patient, the family as a whole is also affected by a loved one with a terminal illness. (
  • Respite Care - Caring for a loved one who has a terminal illness can be overwhelming and exhausting. (
  • Many people with a terminal condition, or who have a loved one with a life-limiting illness, have heard of hospice care. (
  • They also care for young adults who are physically disabled and people with a terminal illness. (
  • Allows you to request a portion of your death benefit early if diagnosed with a terminal illness. (
  • Please share it with your friends, family, and contacts that have either a chronic or terminal illness. (
  • We are ellenor, a charity funded by the generosity of our local community, offering the best care and support to families facing terminal illness in Kent. (
  • For patients and family caregivers the journey through illness and transitions of care is characterized by a series of progressive physical and emotional losses. (
  • OBJECTIVES: Assessment of attitudes held by the general population and medical practitioners in Japan regarding medical interventions in cases of painful terminal illness or a prolonged vegetative state. (
  • The current legal definition of 'terminal illness' is not in keeping with the definition of 'end of life' and lacks any clinical relevance. (
  • The inquiry also revealed that the current definition of 'terminal illness', which determines eligibility for fast-tracked benefits, was introduced by politicians 29 years ago, without clinical evidence. (
  • Madeleine Moon MP previously introduced the Access to Welfare (Terminal Illness Definition) Bill to change this. (
  • A DWP spokesperson said: 'Terminal illness is devastating and our priority is dealing with people's claims quickly and compassionately. (
  • Credit: Courtesy of PD images) The two words 'terminal illness' are powerful enough to bring us to our knees. (
  • Still, when we get the news for ourselves or for a loved one of terminal illness, it is a full-on shock to our systems. (
  • Alzheimer's certainly qualifies as a terminal illness, but it's gentler in some ways, though considerably longer. (
  • You can't hide from a terminal illness. (
  • At VITAS, we tailor our clinical care and our support services to meet the unique symptoms and social and emotional needs that can accompany each specific condition or illness. (
  • Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual. (
  • Studies of recent advances in therapies designed to alleviate pain have substantiated the safety of their use in various treatment regimens for people suffering from terminal illness. (
  • When we speak of "terminal" illness, or illness that will result in death, we are most often speaking of cancer . (
  • Psychological and family support is crucial in terminal illness. (
  • We will explore real-life stories of how modern palliative care is delivered and how it supports individuals and families for the full duration of a life-limiting illness. (
  • Children can receive hospice care along with treatment for their illness. (
  • A patient who has such an illness may be referred to as a terminal patient, terminally ill or simply as being terminal. (
  • The researchers, using multivariable models, found that the increased likelihood of dying in the ICU for black compared to white patients was not explained by differences in education, physical or mental health, insurance, social support, doctor-patient communication, or advance care planning, when taking into account the patient's own preference for more-aggressive care. (
  • It was clear that a patient's preference for aggressive care was the strongest factor in predicting death in an ICU. (
  • Along with the SECPAL, Porta defines "palliative sedation" as the deliberate administration of drugs in a dose and combination required to reduce a terminal patient's consciousness to the extent needed to adequately alleviate one or more refractory symptoms, with the patient's explicit, implicit or surrogate's consent. (
  • Anecdotal evidence indicates aspiration and emesis can sometimes occur during the process of terminal extubation: consider decompression of the patient's stomach contents with a nasogastric tube if already in place. (
  • Reconceptualizing advance care planning from the patient's perspective. (
  • Each patient's status will be regularly evaluated and their plan of care will continuously be changed to meet the needs of symptoms. (
  • Coordinated care at every level - with the consent of the patient's primary physician, and the Hospice Medical Director, a detail plan of care is developed. (
  • Spiritual and emotional support - All Caring Hospice has the necessary resources to make sure each patient's spiritual and emotional needs are met. (
  • Moreover, the need for truly informed consent and the patient's right to health care information and compassionate care create ethical, legal, and humanistic mandates for competency in oncology communication. (
  • Advanced dementia is a terminal diagnosis. (
  • For people with motor neurone disease, early access to palliative care is essential, as one third of people with motor neurone disease die within a year of diagnosis. (
  • Better communication is needed and more sensitivity and empathy are required from health professionals when discussing an end-of-life diagnosis and options such as palliative care. (
  • Significant factors not to die at home were 'dyspnea' , 'no secondary family caregiver' , 'not being notified of a cancer diagnosis' , and 'not wanting to die at home when beginning home medical care' , Commitment of hospitals to provide back-up beds could contribute to reducing the mental burden of patients and their caregivers during home medical care. (
  • This evidence report presents the results of a systematic review to evaluate B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) as promising markers for heart failure diagnosis, prognosis, and treatment. (
  • Background The accurate diagnosis of patients with suspected HF presenting in primary care is difficult. (
  • The accurate diagnosis of heart failure (HF) presenting in primary care is difficult. (
  • For patients diagnosed with HF in primary care, only a minority have that diagnosis confirmed after cardiologic assessment (2) . (
  • Hence, there is a need for a diagnostic test that can improve the accuracy of HF diagnosis in primary care. (
  • Communicating with dying patients within the spectrum of medical care from terminal diagnosis to death. (
  • Learn about communication skills that support a patient-centered practice and how to talk with adults and children about their diagnosis, prognosis, and transition to end-of-life care in this expert-reviewed summary. (
  • A terminal cancer diagnosis is devastating for you, your friends and your family. (
  • Some life insurance plans have accelerated benefits, which allow you to withdraw funds if a terminal diagnosis occurs. (
  • Avoiding financial hardship in the face of a terminal cancer diagnosis can help reduce stress and anxiety. (
  • Death is universal but individuals vary in their diagnosis and social circumstances and this can determine the care and services they receive. (
  • Palliative care can start at the time of diagnosis. (
  • Terminal patients have options for disease management after diagnosis. (
  • Palliative care focuses on addressing patients' needs after disease diagnosis. (
  • Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. (
  • Objective: To assess the incidence of elevated amino-terminal pro-brain natriuretic peptide (NT-pro-BNP) on admission to intensive care and its relation to death in the ICU and within 30 days. (
  • Objectives The purpose of this study was to determine the effect of amino-terminal pro-brain natriuretic peptide (N-BNP) on the diagnostic accuracy of heart failure (HF) in primary care. (
  • Amino-terminal pro-brain natriuretic peptide is present in high levels in cardiac dysfunction and may improve the diagnostic accuracy of HF in primary care. (
  • Black patients with advanced cancer were more likely than whites to die in a hospital intensive care unit, reflecting a greater preference among blacks for life-extending treatment even in the face of a terminal prognosis, according to a study led by researchers at Dana-Farber Cancer Institute in Boston. (
  • For people living with advanced cancer, conversations about prognosis, priorities and end-of-life care may be difficult, but research shows they can also be vitally important in reducing moderate to severe symptoms of anxiety and depression. (
  • This includes (1) the difficulty obtaining hospice when the family wants both palliative care and traditional disease focused care and (2) the limitation of hospice to patients with a six month prognosis---Mitchell's findings clearly show patients need palliative care long before the final six months. (
  • Our aim was to explore experiences of giving or receiving a prognosis and advanced palliative care planning (ACP) for those with HF. (
  • [email protected] Studying end of life in dementia is challenging because of the frailty of the population, additional cognitive problems and difficulty of assessing when patients enter the terminal phase. (
  • Quantitative studies, including observational studies which are frequently ethically appropriate, are helpful to increase the desired evidence base of effective treatment and Mobile phone end-of-life care in dementia patients. (
  • The article has important implications for how we approach and treat advanced dementia in the nursing home and hopefully will spur providers to provide care that reduces and avoids suffering and improves the quality of life of their patients. (
  • He notes, "now some 30 years after my grandmother's death, end-of-life care for dementia does not look all that different from the treatment she received. (
  • Hopefully, recognizing that end stage dementia is a terminal condition will result in improved care---care focused on the quality of life of patients and the needs of their families. (
  • Unfortunately, some aspects of Medicare hospice policy in practice can have the effect of obstructing good care for patients with advanced dementia. (
  • We were surprised to find an increased rate of healthcare use associated with palliative care in those dying from dementia, a finding that will require further study to explain. (
  • Margaret is a Murdoch University researcher and lecturer who has worked in palliative care, oncology and dementia settings for over 20 years. (
  • Dementia care (e.g. (
  • Dementia care The risk of developing dementia increases with age: one in five people will have some form of dementia by the age of 80 which makes it one of the most common diseases of old age. (
  • There are nursing homes which have nurses that are specially trained to care for dementia patients. (
  • Someone with a form of dementia, such as Alzheimer's disease will require 24 hour nursing care and these homes can provide that. (
  • The experience of meaning in the care of patients in the terminal stage of dementia of the Alzheimer type : interpretation of non-verbal communication and ethical demands / by Kenneth Asplund. (
  • OT's) and (OTA's) are traditionally working in hospice care and emerging practice for Alzheimer Disease and Dementia patients to making a difference every day. (
  • Terminal care is not just cancer care but other relevant diseases, which include heart failure , respiratory failure , severe chronic kidney disease , hepatic failure , as well as certain neurological diseases such as multiple sclerosis and motor neurone disease , and dementia . (
  • Three University of Chicago geriatricians are calling for creative and wide-reaching solutions to the problem of sub-optimal end-of-life care for patients with dementia. (
  • With COVID-19 changing life as we know it on a daily basis, HealthiVibe wants to hear from patients with chronic and terminal health conditions. (
  • HealthiVibe is fielding a survey from today through April 10th called " Interruption in Care " to gain feedback from patients living with chronic or terminal health conditions to gauge how COVID-19 is impacting your life right now. (
  • The physiotherapist in this field, is one of the components of the multidisciplinary team that takes care of the patient. (
  • Terminal patients requiring palliative care in a multidisciplinary fashion are taken care of under this roof. (
  • Others highlighted the need to deliver problem-based, individualised care but felt constrained sometimes by the lack of multidisciplinary ACP. (
  • Both the multidisciplinary palliative care team and the neurology team are essential in providing a high standard of care and allowing quality of life (both patient and carer) to be maintained. (
  • It was published by the Leadership Alliance for the Care of Dying People, which was established following an independent review of the Liverpool Care Pathway (LCP), commissioned by the UK government and chaired by Baroness Neuberger. (
  • Report on the LCP(Liverpool care pathway) This report sets out recommendations regarding the Liverpool Care Pathway and end of life care following an independent review of the LCP. (
  • Terminal cancer care and patients' preference for place of death: a prospective study. (
  • Terminal cancer care. (
  • OBJECTIVE--To assess the preference of terminally ill patients with cancer for their place of final care. (
  • CONCLUSION--With a limited increase in community care 50% more patients with cancer could be supported to die at home, as they and their carers would prefer. (
  • This is the first study focused on black/white differences that prospectively asked [terminal cancer patients] what kind of care they wanted at the end of life, and then documented the kind of care they actually received and the place of their death," said Elizabeth Trice, MD, PhD, of Dana-Farber, lead author. (
  • Data on the preferences was obtained from the Coping with Cancer study led by Holly Prigerson, PhD, director of the Center for Psycho-social Oncology and Palliative Care Research at Dana-Farber and an associate professor of psychiatry at Harvard Medical School. (
  • Clinical Care of the Terminal Cancer Patient. (
  • In many sections this book suffers from this problem, presuming that there are patients with terminal and nonterminal cancer. (
  • Such an approach is often counterproductive, because most patients with treatable cancer suffer with terminal problems and, more importantly, most terminally ill patients still hope that some disease-specific treatment may be effective. (
  • Linked health administrative data were used to directly match patients on cause of death, hospital frailty risk score, presence of metastatic cancer, residential location (according to 1 of 14 local health integration networks that organise all healthcare services in Ontario), and a propensity score to receive palliative care that was derived by using age and sex. (
  • In some regions, one in four people dying of cancer has never been referred for palliative care and has not been on a care register. (
  • We retrospectively investigated the clinical course and outcomes of 42 patients with cancer who had received home medical care provided by our hospital. (
  • The bulk of current evidence demonstrating the benefits of palliative care is predominantly found in studies of patients with cancer. (
  • After all, many palliative care programmes were established in cancer centres to care for patients with cancer. (
  • Therapeutics in terminal cancer / Robert G. Twycross, Sylvia A. Lack. (
  • Effective communication in cancer care between the health care team, cancer patients, and their family is important. (
  • It is intended as a resource to inform and assist clinicians who care for cancer patients. (
  • This summary is reviewed regularly and updated as necessary by the PDQ Supportive and Palliative Care Editorial Board, which is editorially independent of the National Cancer Institute (NCI). (
  • Levy MH: Doctor-patient communication: the lifeline to comprehensive cancer care. (
  • Cancer care can also be emotionally taxing on the oncologists who must frequently give bad news and deal with dying and death. (
  • With regards to end of life, the national cancer institute defines comfort care as care give to improve the quality of life of patient who has a serious or life threatening disease. (
  • You'd think that nothing could hurt more than being told you have terminal cancer. (
  • Keep reading for more information on covering the costs associated with paying for terminal cancer care. (
  • As even insured patients struggle with the costs of cancer care, you may want to pursue additional options to cover your medical expenses. (
  • As outlined above, there are several steps you can take to prepare for some of the financial realities associated with terminal cancer. (
  • Palliative Care Services may be involved with patients who are still receiving active cancer treatment such as chemotherapy or radiation therapy, and are not necessarily in their last days or months of life. (
  • Tell us about Parkway Cancer Centre's Palliative Care Services. (
  • The Palliative Care Services in Parkway Cancer Centre (PCC) was set up in July 2008, as part of the centre's push to provide comprehensive cancer care programme for all our patients. (
  • Since 2013, for our efforts to integrate palliative care successfully into our cancer management in PCC, it has earned us the prestigious accreditation as an European Society for Medical Oncology (ESMO) Designated Centre of Integrated Oncology and Palliative Care. (
  • Can you explain broadly what the services are that Palliative Care Services provide in Parkway Cancer Centre? (
  • We provide four main categories of services: Cancer Pain Management, Discharge and Home Care Planning, Advance Care Planning, and End-of-Life Care. (
  • Question: With so many people affected by cancer, why is there so little information about the role of nutrition in cancer care? (
  • Palliative care services, designed to improve the well-being of people with cancer, can be a big help to the suffering person and their relatives. (
  • Today, pain should not be a major reason for suffering in people with terminal cancer. (
  • Living with dying : a guide to palliative care / Cicely Saunders, Mary Baines and Robert Dunlop. (
  • New topics discussed include complementary therapies, personal and family experiences of ALS, new genetics research, and updated guidelines for patient care, to ensure this new edition remains the essential guide to palliative care in ALS. (
  • ESMO, the leading professional organisation for medical oncology, published a position paper on supportive and palliative care in its leading scientific journal, Annals of Oncology today. (
  • Prognostic tools such as the Supportive and Palliative Care Indicators Tool (SPICT) have been validated to identify when a person may require palliative care but are not useful in predicting imminent dying. (
  • Consistent with other studies demonstrating benefit, the use of hospice care is associated with better quality-of-care outcomes, including patient-centered care metrics," study leader Ruth Kleinpell and colleagues write in the journal BMJ Supportive and Palliative Care, online August 16. (
  • We carried out a longitudinal grounded theory study, employing in-depth interviews with 14 clinicians (primary and secondary care) and observations of clinic and home appointments, followed by a series of interviews with 13 patients with HF and 9 carers. (
  • We hope that the statement will spur more and better palliative care curricula in schools and hospitals to help develop or enhance those skills in interested physicians," says Dr. Terry. (
  • In Japan, only a few hospitals play a role in home medical care including end-of-life care. (
  • We surveyed practicing respiratory therapists at 6 acute-care hospitals in a large urban area and asked about particular concerns and attitudes regarding terminal extubation. (
  • Featuring an 8th gen Intel® processor , POC-621 is a high-performance, ultra-thin terminal that enables improved operational effectiveness in hospitals, clinics, and care homes. (
  • Palliative care is delivered in many settings, including acute hospitals, community and residential care settings. (
  • The majority of patients today still die in hospitals," said Kleinpell, a professor at the Rush University College of Nursing in Chicago who works in a critical care unit at Rush University Medical Center. (
  • Susan Miller, who specializes in hospice and palliative care at Brown University School of Public Health in Providence, Rhode Island but who was not involved with the current study, said for patients nearing the end of life, hospitals' palliative care teams "typically address management of symptoms such as pain and include discussion of goals of care including the choice of hospice. (
  • Hospice and palliative care professionals are especially educated to help patients with terminal illnesses or conditions. (
  • Hospice and palliative care : an interdisciplinary approach / edited by Cicely Saunders. (
  • end-of-life care is available through hospice and palliative care programs, there should be no reason anyone would need to seek PAS" (1). (
  • Consequently, greater numbers of people now require palliative care. (
  • Hall, an 82-year-old former World War II prisoner of war who is serving a life sentence for murder, has spent nearly a decade in the infirmary at Iowa State Penitentiary with a terminal heart ailment. (
  • Pain one's health, the palliative care concern the last period of a man's life, trying to give him back the largest possible self-sufficiency. (
  • The AMA Code of Medical Ethics provides additional guidance on end-of-life care, such as Chapter 5, " Opinions on Caring for Patients at the End of Life ," which covers topics including advance care planning, advance directives and orders not to attempt resuscitation. (
  • 1 Beyond discussions of advance directives, goals of care, POLST forms, and hospice services, providing palliation and end-of-life care has become an important aspect of emergency medicine. (
  • Several studies have shown that open and clear dialogue with families regarding their relative's wishes and symptom management contributed to higher family satisfaction during end of life care in ICUs. (
  • This brochure was created by Improving End-of-Life Care in First Nations Communities Centre for Education and Research on Aging & Health. (
  • It explains what changes to expect when caring for a loved one at the end-of-life. (
  • An Analysis of Recruitment Efficiency for an End-of-Life Advance Care Planning Randomized Controlled Trial. (
  • Shared decision-making in end-stage renal disease: a protocol for a multi-center study of a communication intervention to improve end-of-life care for dialysis patients. (
  • Palliative care needs to go hand in hand with hospital treatment and should be available for all people with advanced and progressive illnesses and life-shortening conditions. (
  • Sufferers should be able to plan ahead for their end-of-life care and ensure that their wishes are known. (
  • Research has shown that early referral for palliative care can improve the quality of life and lengthen it. (
  • We need to have properly funded nationwide palliative care provision that is integrated with local authorities, community care providers and local NHS providers, so that there is a comprehensive and coherent way of addressing end-of-life care. (
  • There is still a big taboo about talking about end-of-life care and there is limited understanding among the public about what palliative care is and when it is appropriate. (
  • The health care cost of dying: a population-based retrospective cohort study of the last year of life in Ontario, Canada. (
  • Communication and planning for heart failure (HF) care near the end of life is known to be complex. (
  • Overall however, there were positive associations between the number of physician visits and the recognition of the resident's terminal phase and between the number of physician visits and the resident having palliation as main treatment goal in the last week of life. (
  • The End-of-Life Care Research Group aims to conduct high-quality scientific research in end-of-life care in Belgium and Europe. (
  • The research group is spearheaded by a number of experienced researchers and strives to expand expertise in end-of-life care research. (
  • BACKGROUND Efforts to improve communication between physicians and dying patients have been unsuccessful, and guidelines for improving patient-physician communication about end-of-life care are based primarily on expert opinion. (
  • This study assessed which aspects of communication between patients and physicians are important in end-of-life care. (
  • What is wrong with end-of-life care? (
  • At All Caring Hospice, we understand that patients with life-limiting conditions or terminal illnesses have unique experiences. (
  • Support with difficult decisions - Hospice care helps families make difficult decisions and choices that may impact their loved ones health and quality of life. (
  • The management of pain in the terminal stage of life : general recommendations / from the Swedish National Board of Health and Welfare. (
  • Practicing in the area of hospice, I am often faced with caring for patients at end of life. (
  • You may find the End of Life Care article more useful, or one of our other health articles . (
  • A report from the National End of Life Care Intelligence Network compared people's preferences for place of death with actual place of death in England and reported that variations exist across the country and between conditions (69% of people with non-cancerous respiratory conditions die in hospital) [ 3 ] . (
  • Five "Priorities of Care" are described and form the focus of care at the end of life. (
  • This includes pain and symptom relief, end of life care, respite, bereavement support and emotional and spiritual care. (
  • Palliative medicine is the branch of medicine in palliative care, which aims to relieve suffering and improve the quality of life of patients who are facing life-threatening illnesses such as advanced cancers. (
  • No, although terminal care or hospice care (which generally implies the medical care in the last few days or months of life) is an important part in palliative care. (
  • End-Of- Life Care addresses the many symptoms that patients experience in their last hours, days or weeks of life. (
  • 68-76% of the general population and medical practitioners expressed disapproval of life-extending medical treatment of terminal patients suffering pain. (
  • 5. Most medical practitioners felt that some medical treatments, such as bedsore care, should be continued in lieu of life support, but there were differences in opinion between practitioners at various types of medical facilities regarding the necessity of such specific measures as, for example, blood pressure monitoring by automatic sphygmomanometer among the medical facilities. (
  • CONCLUSION: Both the general population and the medical practitioners in Japan tended to oppose life-extending medical treatment for painful terminal cases and patients in a prolonged vegetable state. (
  • The Australian Commission on Safety and Quality in Health Care defines dying as 'the terminal phase of life, where death is imminent and likely to occur within hours or days, or occasionally weeks. (
  • Key barriers to implementing adequate care in the terminal phase are an inability of health care professionals in recognising a patient is dying, a lack of skills about how to manage symptoms in the last days or hours of life and how to communicate with patients and families about this process. (
  • 6,7] A systematic review examining the elements of care considered by patients and families as being of importance at the end of life established that effective communication and shared decision making, receiving expert care, and receiving respectful and compassionate care were important. (
  • Not all people who are in their last months or days of life are referred to specialist palliative care services despite some evidence that referral to specialist services can benefit many patients. (
  • 10] Therefore, care in the last days of a person's life is being delivered by both specialist and non-specialist services. (
  • Hospice care is a specific type of palliative care for patients in the last six months of life. (
  • To receive hospice care, adults need to end life-prolonging treatment. (
  • To evaluate, in patients with heart failure, the effect of a self-care promotion program using a multifaceted strategy in comparison to the usual care about acceptability to the application of SMS, patient and / or family satisfaction with care, quality of life scales health scales, self-care scales and knowledge on HF, visual analog scale of dyspnea, and clinical outcomes at 30 and 180 days. (
  • Reuters Health) - A new study adds to evidence that hospice care during the last six months of life is associated with better overall experiences for patients and a lower likelihood of dying in a hospital. (
  • If someone is hospitalized and approaching the end of life, hospice care is more optimal so they can get the care they need," she told Reuters Health by phone. (
  • There is no standardized life expectancy for a patient to be considered terminal, although it is generally months or less. (
  • Life expectancy for terminal patients is a rough estimate given by the physician based on previous data and does not always reflect true longevity. (
  • Because terminal patients are aware of their oncoming deaths, they have more time to prepare advance care planning, such as advance directives and living wills, which have been shown to improve end-of-life care. (
  • Palliative care is normally offered to terminally ill patients, regardless of their overall disease management style, if it seems likely to help manage symptoms such as pain and improve quality of life. (
  • Palliative care can also help patients make decisions and come to understand what they want regarding their treatment goals and quality of life. (
  • OBJECTIVE Circulating levels of NH 2 -terminal probrain natriuretic peptide (NT-proBNP), a marker of acute heart failure, are associated with increased risk of cardiovascular disease (CVD) in the general population. (
  • And because this is a progressive disease it means that the sufferer will require specialist care in the later stages. (
  • Palliative care must therefore be integral to the clinical approach to the disease. (
  • it must cover not just the terminal phase, but support the patient and their family from the onset of the disease. (
  • Clear guidelines are provided to address care throughout the disease process. (
  • Patients and their families are usually aware that prognostic advice on the basis of disease trajectory is uncertain but they do expect the conversation and avoidance 'jeopardises patient- and family-centred out-comes' [1] The development of guidelines to support point of care decision making are now available. (
  • This session will provide a brief overview of the personal care needs, as well as communication with family for someone who is in the terminal phase of their disease. (
  • 6. Reynes JM, Carli D, Boukezia N, Debruyne M, Herti S. virus disease care units in a hospital in Maryland, USA, Tula hantavirus infection in a hospitalised patient, France, during May-June 2020. (
  • While palliative care is not disease treatment, it addresses patients' physical needs, such as pain management, offers emotional support, caring for the patient psychologically and spiritually, and helps patients build support systems that can help them get through difficult times. (
  • NH 2 -terminal probrain natriuretic peptide (NT-proBNP) is the inactive molecule resulting from cleavage of brain natriuretic peptide prohormone ( 1 ). (
  • Context: Amino-terminal pro-brain-type natriuretic peptide is known to predict outcome in patients with heart failure, but its role in an intensive care setting is not yet fully established. (
  • Brain natriuretic peptide (BNP), released mainly by the ventricle, is elevated in HF and offers promise as a diagnostic test in primary care. (
  • How are brain natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels used in the evaluation of left ventricular (LV) function? (
  • Main outcome measures Rates of emergency department visits, admissions to hospital, and admissions to the intensive care unit, and odds of death at home versus in hospital after first palliative care visit, adjusted for patient characteristics (such as age, sex, and comorbidities). (
  • Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Norrköping. (
  • Patients and main outcome measures NT-pro-BNP was collected from 481 consecutive patients on admission to intensive care, in addition to data on patient characteristics and outcome. (
  • Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. (
  • Objectives: To develop and implement a fully mobile computer terminal that interfaces with our computerized intensive care unit (ICU) local area network and order management system. (
  • We provide services to families with a newborn in Doernbecher's Neonatal Intensive Care Unit. (
  • Intensive care. (
  • Kieran Quinn , General Internal Medicine and Palliative Care, Sinai Health System and PhD Candidate, Clinical Epidemiology & Health Care Research, Institute of Health Policy, Management and Evaluation, Eliot Phillipson Clinician-Scientist Training Program, University of Toronto. (
  • It's comprehensive and covers palliative care for children and adults, as well as for patients with pulmonary disorders or critical illnesses," said Paul N. Lanken, M.D., professor of medicine and medical ethics at the Hospital of the University of Pennsylvania and co-chair of the ATS task force that wrote the statement. (
  • We are the only charity in the county that provides hospice care for people of all ages - babies, children and adults - and their families. (
  • We care for young adults who've been with us since they were younger. (
  • By doing this, you can better plan for future costs such as hospice and respite care. (
  • Comfort measures and terminal extubation may be among the most important procedures you perform during a shift. (
  • Comfort measures and terminal extubation may be one of the most important procedures you perform during your shift. (
  • Prior to terminal extubation, consider several steps to prepare the patient. (
  • The majority of respiratory therapists had participated in terminal extubation, but most were not regular participants in the decision-making process leading to withdrawal. (
  • Practicing respiratory therapists expressed a desire for a role in the decisionmaking process, education regarding terminal care, and more definitive orders for terminal extubation. (
  • [email protected] In Italy, more than 250.000 people are in need of palliative care every year. (
  • This graph shows the total number of publications written about "Terminal Care" by people in this website by year, and whether "Terminal Care" was a major or minor topic of these publications. (
  • Below are the most recent publications written about "Terminal Care" by people in Profiles. (
  • One in every two people is touched by hospice care, which makes what we do very relevant. (
  • That's a lot of people who will get the terminal shuttle train jingles stuck in their heads. (
  • Even though DIA was the first airport Green worked with, he now has sound installations in terminals around the U.S. Thousands of people experience Green's artwork daily, but not many know what they are hearing is art. (
  • These provide the same facilities as a residential home but are geared towards people who require long term or complex nursing care. (
  • These types of homes provide care to people who are physically disabled and are unable to manage at home. (
  • Terminal care for people with AIDS / Ruth Sims, Veronica A. Moss. (
  • In addition the Care Quality Commission (CQC) has found significant variations in the quality of care received by, for example, people of different ethnic background, sexual orientation and social background [ 4 ] . (
  • however, at least 63% of people express a preference to die at home and provision of palliative home care has been shown to be key to achieving this [ 6 ] . (
  • It provides guidance in the care of dying people and is aimed at all clinicians everywhere - hospital and community. (
  • is typified by looking at what that care is like from the perspective of the dying person and the people who are important to them and developing and delivering an individualised plan of care to achieve the essentials of good care. (
  • Many people are facing an interruption in care because of COVID-19. (
  • 10] Of those people who died in a hospital 72 per cent received services from specialist palliative care. (
  • 12] Providing people with an ongoing opportunity to discuss their preferences for place of care and place of death separately is as important as providing them with an opportunity to change their preference. (
  • Ask The Treatment Expert: Is a Kennedy Terminal Ulcer a pressure injury? (
  • A Kennedy Terminal Ulcer is a pressure injury that develops on residents as they are dying. (
  • A Kennedy Terminal Ulcer tends to have a sudden rapid onset, developing in a matter of hours. (
  • Treatment of a Kennedy Terminal Ulcer is the same as for any other pressure injury with the same characteristics. (
  • Control of symptoms is covered alongside the psychosocial care of patients and their families. (
  • The Effectiveness of Hospice Care for Delirium Patients Cierra J. Williams AHS 128 Midland Technical College Abstract The limitation of hospice care is focused on the idea of providing delirium patients and their families with a peaceful encounter of an acceptable death. (
  • The All Caring Hospice team tailors their clinical care to meet the needs of each patient. (
  • Terminal Sedation Or Palliative Sedation? (
  • Last year, a call for "terminal sedation" to be covered by the same legal regulation as euthanasia gave rise to a public debate in The Netherlands. (
  • Doctors, supported by the health minister, strongly argued that terminal sedation and the withdrawal of artificial feeding and hydration are "normal medical treatment" and therefore "different from euthanasia" (Cf. Sheldon T: "Terminal sedation" different from euthanasia, Dutch ministers agree. (
  • The debate on "terminal sedation" still continues around the world. (
  • While some consider this praxis as normal medical treatment, others wonder whether it does rather represent "euthanasia in disguise" (Cf. Tännsjö T (ed): Terminal sedation: Euthanasia in Disguise? (
  • Commenting on the ambiguity of the use of the expression "terminal sedation" in the medical literature, Porta analyzes various definitions that have been used during the past years. (
  • This definition captures the traditional way of understanding the role of sedation in palliative care, as stated already - for instance - in the Oxford Textbook of Palliative Care (p. 407): "The goal of palliative terminal sedation is to provide the dying patient relief of otherwise refractory, intolerable symptoms, and it is therefore firmly within the realm of good, supportive palliative care and is not euthanasia. (
  • Health care providers do not necessarily make more money for longer hospice stays. (
  • Alternative medicine consists of a wide range of health care practices, products, and therapies. (
  • Palliative and terminal care : health care needs assessment : the epidemiologically based needs assessment reviews, second series / edited by Andrew Stevens and James Raftery. (
  • Health care needs assessment. (
  • Originally published in: Health care needs assessment. (
  • It does not provide formal guidelines or recommendations for making health care decisions. (
  • There is an interest in the benefits of telecare health care services, especially among patients who require hospice care. (
  • Telecare is not a new phenomenon in the health care industry, it has evolved into an important aspect of health care and hospice. (
  • Introduction Kolcaba defines comfort care for nursing as a "philosophy of health care that focuses on addressing physical, psychospiritual, sociocultural, and environmental comfort needs of patients (kolcaba, 2003, p. 252). (
  • Choice of health care professional. (
  • Health care professionals report they are under skilled in these areas. (
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (
  • Your submission to Program in Health Care Organization and Policy has been sent. (
  • The University of Alabama at Birmingham / Program in Health Care Organization and Policy is located in Birmingham, AL, in an urban setting. (
  • Someone who can't afford health care may be pressured into assisted suicide. (
  • Defence: Canada has health care and it is becoming more popular in the United States. (
  • reflection The right to consent and refuse treatment is a fundamental right that must be honoured by health care staff. (
  • Home health care services 645.5-645.9. (
  • Paediatric palliative care rehabilitation project. (
  • It recognizes palliative care as an important part of what doctors, nurses and other healthcare professionals should be doing. (
  • Our chemotherapy day care is run by fully trained staff that comprises 6 chemotherapy nurses who work under the supervision of at least one oncologist. (
  • This means nurses will be expected to provide a palliative approach to care when needed. (
  • It is essential that nurses are provided with the knowledge and skills required to provide good-quality palliative care when required. (
  • The purpose of this program is to provide education to nurses so they can provide a palliative approach to care in any setting. (
  • The book covers both caring for the terminally ill and the 'actual' bereavement, thus providing guidance on the whole process of counselling patients and their families. (
  • Case studies are used to emphasise the complexity of the care needs and involvement of the patient and family, culminating in discussion of bereavement. (
  • and finally, the expanding expectancies of the population in complex international locations for a finished and delicate carrier for sufferers, kin and care givers on the terminal section of ailment. (
  • Caregiver support, custodial care, respite (for patients at home) etc. (
  • Palliat Support Care. (
  • Spiritual and emotional support - Hospice care helps meet the spiritual and emotional needs of not only the patient, but also their loved ones. (
  • An individual plan of care, which includes food and drink, symptom control and psychological, social and spiritual support, is agreed, co-ordinated and delivered with compassion. (
  • Hospice care offers symptom management, emotional and spiritual support, and it's a Medicare benefit," she said. (
  • Hospice care, which can be provided at home or in a long-term care facility, additionally provides emotional and spiritual support for the patient and loved ones. (
  • Learn with the AMA how adapting to E/M coding changes can help boost patient care and professional satisfaction. (
  • Terminal patient care: advantages on the applicability of anticipated will directives in the hospital context. (
  • The present invention is directed to a system and method for providing care to a patient, comprising a patient care device having a number of configuration databases stored in a memory in the device. (
  • In a preferred embodiment, programming a patient care device to deliver a drug to a patient entails activating a configuration database and scanning a machine-readable drug label identifying a particular protocol stored in the activated database. (
  • means for activating a configuration database from said plurality of configuration databases based at least in part on said patient-specific information communicated to the care device, wherein the patient care device operates in accordance with at least one of said plurality of groups of operating parameters of the activated configuration database. (
  • 5 . The system of claim 1 , wherein the patient-specific information comprises any of a patient identifier, a patient location, a patient care device location, patient age, a physical characteristic or a medical characteristic. (
  • 9 . The system of claim 1 , wherein said selecting means comprises a patient care device location sensor, such that selection of the specific configuration database is based, at least in part, on a location of the patient care device. (
  • This session reviews the concept of a palliative approach to care. (
  • Professional competence and development of specific skills for healthcare providers who are involved in palliative care, especially the ability to communicate compassionately and effectively in order to help patients and/or family members make decisions about their care by determining treatment goals, developing appropriate strategies in line with those goals and preparing advance directives. (
  • community care provision required for home care. (
  • Unfortunately, the provision of palliative care is patchy at best. (
  • Joint working will facilitate the recognition of a resident's terminal phase and the timely provision of palliative care. (
  • Each may bring its own challenges in terms of the provision of terminal care. (
  • The statement also provides practical information for clinicians, such as when to consider referral to hospice care and how to withdraw mechanical ventilation. (
  • 9] Based on AIHW data, in 2017 approximately 49 per cent of Australians died in hospital, 35 percent died in Residential Aged Care Facilities and 16 per cent died elsewhere. (
  • Access to pediatric care. (
  • The Bridges Pediatric Palliative Care Program is the largest children's palliative care program in Oregon. (
  • Dr. Robert Macauley, our medical director, is a national expert in pediatric palliative care. (
  • He holds OHSU's Cambia Health Foundation Endowed Chair in Pediatric Palliative Care. (
  • Inpatient hospice care facilities are available, if needed, should symptoms become too difficult to manage at home. (
  • We help to assess and address these symptoms so that patients can be more comfortable in the place of care. (
  • Care of a person who is imminently dying involves both clinical and ethical considerations but is based on a thorough assessment of current symptoms and forward planning for common problems. (
  • Terminal patients often need a caregiver, who could be a nurse, licensed practical nurse or a family member. (
  • Palliative care was once reserved for patients when all curative options had been exhausted and death was imminent, but now it is considered an integral part of the care that should be available to patients with serious respiratory disorders and critical illnesses. (
  • Number of physician visits, the resident's main treatment goal, whether physicians recognized the resident's terminal phase and expected the resident's death, and resident and physician characteristics. (
  • Here, the striking terminal bead announces the constant proximity of death by joining a skull to the pair of vivacious lovers. (
  • See related separate articles Helping Patients Face Death and Dying and Palliative Care . (
  • Use your death benefit to pay for long-term care. (
  • Palliative care is meant to be comforting and enjoyable, but when a patient receives excessive amount of care attention, they are being constantly reminded of their death in the near future, which could heighten depression and sadness of family and friends. (
  • Oftentimes, terminal patients may experience depression or anxiety associated with oncoming death, and family and caregivers may struggle with psychological burdens as well. (
  • MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow. (
  • In the past 15 years, palliative care has emerged from near obscurity to become a board-certified medical specialty for physicians and a prominent part of contemporary healthcare for all providers and their patients. (
  • Terminal Care" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • This clinic comprises Hickman catheter or port care and is being run and managed by specially trained nursing staff and chemotherapy sisters, supervised by medical oncologists. (
  • Dr. A R Fakih has treated several patients in India and gives every patient the best of medical care. (
  • Advance Care Planning is a new concept to help the patient to plan and document his wishes/preferences regarding his medical treatment in advance and to appoint a substitute decision maker in the event that he loses the mental capacity to do so later. (
  • Examples of such patient-specific information include patient age or size, patient medical characteristics, a location of the patient or a location of the care device. (
  • There are some differences in opinion between the general population and practitioners at various types of medical facilities regarding the extent of desirable medical care in such circumstances. (
  • Kojima, M. / Attitudes towards terminal care among the general population and medical practitioners in Japan . (
  • Decisions regarding management are made by the patient and his or her family, although medical professionals may give recommendations or more about the services available to terminal patients. (
  • Evaluation and quality control of medical care. (
  • Economics of medical care. (
  • Provisions for personal medical care. (
  • Medical care plans 418-418.5. (
  • mps-youtube allows you to download YouTube content from the Terminal. (