Telomere. Medical search

A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.

Maintenance of TELOMERE length. During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING.) Various cellular mechanism are involved in repairing, extending, and recapping the telomere ends.

An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.

Proteins that specifically bind to TELOMERES. Proteins in this class include those that perform functions such as telomere capping, telomere maintenance and telomere stabilization.

A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.

A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.

The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.

A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

A genus of ciliate protozoa having a unique cursorial type of locomotion.

An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.

Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.

White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

An increased tendency of the GENOME to acquire MUTATIONS when various processes involved in maintaining and replicating the genome are dysfunctional.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

A genus of ciliate protozoa having a dorsoventrally flattened body with widely spaced rows of short bristle-like cilia on the dorsal surface.

A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.

Deoxyribonucleic acid that makes up the genetic material of fungi.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products.

Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.

Immunologically detectable substances found in the CELL NUCLEUS.

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

Changes in the organism associated with senescence, occurring at an accelerated rate.

The process by which a DNA molecule is duplicated.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

A DNA-binding protein that mediates DNA REPAIR of double strand breaks, and HOMOLOGOUS RECOMBINATION.

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

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A publication issued at stated, more or less regular, intervals.

"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. (1/4834)

Life span determination in normal human cells may be regulated by nucleoprotein structures called telomeres, the physical ends of eukaryotic chromosomes. Telomeres have been shown to be essential for chromosome stability and function and to shorten with each cell division in normal human cells in culture and with age in vivo. Reversal of telomere shortening by the forced expression of telomerase in normal cells has been shown to elongate telomeres and extend the replicative life span (H. Vaziri and S. Benchimol, Curr. Biol. 8:279-282, 1998; A. G. Bodnar et al., Science 279:349-352, 1998). Extension of the life span as a consequence of the functional inactivation of p53 is frequently associated with loss of genomic stability. Analysis of telomerase-induced extended-life-span fibroblast (TIELF) cells by G banding and spectral karyotyping indicated that forced extension of the life span by telomerase led to the transient formation of aberrant structures, which were subsequently resolved in higher passages. However, the p53-dependent G1 checkpoint was intact as assessed by functional activation of p53 protein in response to ionizing radiation and subsequent p53-mediated induction of p21(Waf1/Cip1/Sdi1). TIELF cells were not tumorigenic and had a normal DNA strand break rejoining activity and normal radiosensitivity in response to ionizing radiation. (+info)

A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. (2/4834)

Reactivation of telomerase and stabilization of telomeres occur simultaneously during human cell immortalization in vitro and the vast majority of human cancers possess high levels of telomerase activity. Telomerase repression in human somatic cells may therefore have evolved as a powerful resistance mechanism against immortalization, clonal evolution and malignant progression. The comparative ease with which rodent cells immortalize in vitro suggests that they have less stringent controls over replicative senescence than human cells. Here, we report that Syrian hamster dermal fibroblasts possess substantial levels of telomerase activity throughout their culture life-span, even after growth arrest in senescence. In our studies, telomerase was also detected in uncultured newborn hamster skin, in several adult tissues, and in cultured fibroblasts induced to enter the post-mitotic state irreversibly by serum withdrawal. Transfection of near-senescent dermal fibroblasts with a selectable plasmid vector expressing the SV40 T-antigen gene resulted in high-frequency single-step immortalization without the crisis typically observed during the immortalization of human cells. Collectively, these data provide an explanation for the increased susceptibility of rodent cells to immortalization (and malignant transformation) compared with their human equivalents, and provide evidence for a novel, growth factor-sensitive, mammalian senescence mechanism unrelated to telomere maintenance. (+info)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (3/4834)

Small polydisperse circular DNA (spcDNA) is a heterogeneous population of extrachromosomal circular molecules present in a large variety of eukaryotic cells. Elevated amounts of total spcDNA are related to endogenous and induced genomic instability in rodent and human cells. We suggested spcDNA as a novel marker for genomic instability, and speculated that spcDNA might serve as a mutator. In this study, we examine the presence of telomeric sequences on spcDNA. We report for the first time the appearance of telomeric repeats in spcDNA molecules (tel-spcDNA) in rodent and human cells. Restriction enzyme analysis indicates that tel-spcDNA molecules harbor mostly, if not exclusively, telomeric repeats. In rodent cells, tel-spcDNA levels are higher in transformed than in normal cells and are enhanced by treatment with carcinogen. Tel-spcDNA is also detected in some human tumors and cell lines, but not in others. We suggest, that its levels in human cells may be primarily related to the amount of the chromosomal telomeric sequences. Tel-spcDNA may serve as a unique mutator, through specific mechanisms related to the telomeric repeats, which distinguish it from the total heterogeneous spcDNA population. It may affect telomere dynamics and genomic instability by clastogenic events, alterations of telomere size and sequestration of telomeric proteins. (+info)

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (4/4834)

Although broken chromosomes can induce apoptosis, natural chromosome ends (telomeres) do not trigger this response. It is shown that this suppression of apoptosis involves the telomeric-repeat binding factor 2 (TRF2). Inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. The response was mediated by p53 and the ATM (ataxia telangiectasia mutated) kinase, consistent with activation of a DNA damage checkpoint. Apoptosis was not due to rupture of dicentric chromosomes formed by end-to-end fusion, indicating that telomeres lacking TRF2 directly signal apoptosis, possibly because they resemble damaged DNA. Thus, in some cells, telomere shortening may signal cell death rather than senescence. (+info)

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. (5/4834)

To study the effect of continued telomere shortening on chromosome stability, we have analyzed the telomere length of two individual chromosomes (chromosomes 2 and 11) in fibroblasts derived from wild-type mice and from mice lacking the mouse telomerase RNA (mTER) gene using quantitative fluorescence in situ hybridization. Telomere length at both chromosomes decreased with increasing generations of mTER-/- mice. At the 6th mouse generation, this telomere shortening resulted in significantly shorter chromosome 2 telomeres than the average telomere length of all chromosomes. Interestingly, the most frequent fusions found in mTER-/- cells were homologous fusions involving chromosome 2. Immortal cultures derived from the primary mTER-/- cells showed a dramatic accumulation of fusions and translocations, revealing that continued growth in the absence of telomerase is a potent inducer of chromosomal instability. Chromosomes 2 and 11 were frequently involved in these abnormalities suggesting that, in the absence of telomerase, chromosomal instability is determined in part by chromosome-specific telomere length. At various points during the growth of the immortal mTER-/- cells, telomere length was stabilized in a chromosome-specific man-ner. This telomere-maintenance in the absence of telomerase could provide the basis for the ability of mTER-/- cells to grow indefinitely and form tumors. (+info)

Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis. (6/4834)

Checkpoint mechanisms that respond to DNA damage in the mitotic cell cycle are necessary to maintain the fidelity of chromosome transmission. These mechanisms must be able to distinguish the normal telomeres of linear chromosomes from double-strand break damage. However, on several occasions, Drosophila chromosomes that lack their normal telomeric DNA have been recovered, raising the issue of whether Drosophila is able to distinguish telomeric termini from nontelomeric breaks. We used site-specific recombination on a dispensable chromosome to induce the formation of a dicentric chromosome and an acentric, telomere-bearing, chromosome fragment in somatic cells of Drosophila melanogaster. The acentric fragment is lost when cells divide and the dicentric breaks, transmitting a chromosome that has lost a telomere to each daughter cell. In the eye imaginal disc, cells with a newly broken chromosome initially experience mitotic arrest and then undergo apoptosis when cells are induced to divide as the eye differentiates. Therefore, Drosophila cells can detect and respond to a single broken chromosome. It follows that transmissible chromosomes lacking normal telomeric DNA nonetheless must possess functional telomeres. We conclude that Drosophila telomeres can be established and maintained by a mechanism that does not rely on the terminal DNA sequence. (+info)

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. (7/4834)

Mice genetically deficient for the telomerase RNA (mTR) can be propagated for only a limited number of generations. In particular, mTR-/- mice of a mixed C57BL6/129Sv genetic background are infertile at the sixth generation and show serious hematopoietic defects. Here, we show that a percentage of mTR-/- embryos do not develop normally and fail to close the neural tube, preferentially at the forebrain and midbrain. The penetrance of this defect increases with the generation number, with 30% of the mTR-/- embryos from the fifth generation showing the phenotype. Moreover, mTR-/- kindreds in a pure C57BL6 background are only viable up to the fourth generation and also show defects in the closing of the neural tube. Cells derived from mTR-/- embryos that fail to close the neural tube have significantly shorter telomeres and decreased viability than their mTR-/- littermates with a closed neural tube, suggesting that the neural tube defect is a consequence of the loss of telomere function. The fact that the main defect detected in mTR-/- embryos is in the closing of the neural tube, suggests that this developmental process is among the most sensitive to telomere loss and chromosomal instability. (+info)

Generation and characterization of human smooth muscle cell lines derived from atherosclerotic plaque. (8/4834)

The study of atherogenesis in humans has been restricted by the limited availability and brief in vitro life span of plaque smooth muscle cells (SMCs). We describe plaque SMC lines with extended life spans generated by the expression of the human papillomavirus (HPV)-16 E6 and E7 genes, which has been shown to extend the life span of normal adult human aortic SMCs. Resulting cell lines (pdSMC1A and 2) demonstrated at least 10-fold increases in life span; pdSMC1A became immortal. The SMC identity of both pdSMC lines was confirmed by SM22 mRNA expression. pdSMC2 were generally diploid but with various structural and numerical alterations; pdSMC1A demonstrated several chromosomal abnormalities, most commonly -Y, +7, -13, anomalies previously reported in both primary pdSMCs and atherosclerotic tissue. Confluent pdSMC2 appeared grossly similar to HPV-16 E6/E7-expressing normal adult aortic SMCs (AASMCs), exhibiting typical SMC morphology/growth patterns; pdSMC1A displayed irregular cell shape/organization with numerous mitotic figures. Dedifferentiation to a synthetic/proliferative phenotype has been hypothesized as a critical step in atherogenesis, because rat neonatal SMCs and adult intimal SMCs exhibit similar gene expression patterns. To confirm that our pdSMC lines likewise express this apparent plaque phenotype, osteopontin, platelet-derived growth factor B, and elastin mRNA levels were determined in pdSMC1A, pdSMC2, and AASMCs. However, no significant increases in osteopontin or platelet-derived growth factor B expression levels were observed in either pdSMC compared with AASMCs. pdSMC2 alone expressed high levels of elastin mRNA. Lower levels of SM22 mRNA in pdSMC1A suggested greater dedifferentiation and/or additional population doublings in pdSMC1A relative to pdSMC2. Both pdSMC lines (particularly 1A) demonstrated high message levels for matrix Gla protein, previously reported to be highly expressed by human neointimal SMCs in vitro. These results describe 2 novel plaque cell lines exhibiting various features of plaque SMC biology; pdSMC2 may represent an earlier plaque SMC phenotype, whereas pdSMC1A may be representative of cells comprising an advanced atherosclerotic lesion. (+info)

Telomeres When telomeres of chromosomes shorten with continued cell divisions, the chromosome ends may also fuse, forming ... Chromosomal inversion Telomeres Cytogenetics Nuclear radiation Intellectual disorders Nussbaum, Robert; McInnes, Roderick; ... Boukamp, Petra; Popp, Susanne; Krunic, Damir (2005-11-01). "Telomere-Dependent Chromosomal Instability". Journal of ...

https://en.wikipedia.org/wiki/Dicentric_chromosome

Telomere is a mysterious terrorist organization that is behind the attacks on The Bund. Fake Mina A female vampire who posed as ... It is later revealed that he is a mole for Telomere. The Eight Elite consists of the best hunters in the Earth Clan. Each ... Hysterica had a habit of referring to her slaves as "Pigs." In the anime, she worked for Telomere, but still tried to contact ... In the anime, it is heavily suggested one or all of them are controlling Telomere, a terrorist group created to kill Mina. Also ...

https://en.wikipedia.org/wiki/List_of_Dance_in_the_Vampire_Bund_characters

Thus, reprogramming leads to the restoration of embryonic telomere length, and hence increases the potential number of cell ... It was found that reprogramming leads to telomere lengthening and subsequent shortening after their differentiation back into ... West, M. D.; Vaziri, H (2010). "Back to immortality: The restoration of embryonic telomere length during induced pluripotency ... Marión, R. M.; Blasco, M. A. (2010). "Telomere rejuvenation during nuclear reprogramming". Current Opinion in Genetics & ...

https://en.wikipedia.org/wiki/Induced_stem_cells

Author of The Telomere (1995). Professor Thomas Burton Loram Kirkwood CBE (1951-) Dr James Brown (1975-)Elected to membership ( ...

https://en.wikipedia.org/wiki/British_Society_for_Research_on_Ageing

A dosage of 800 mg/day danazol was found to increase telomere length in patients with telomere diseases in a phase I/II ... "Danazol Treatment for Telomere Diseases". N.E.J.M. 374 (20): 1922-31. May 2016. doi:10.1056/NEJMoa1515319. Hoffman, Barbara L; ... The study was halted early, after telomere attrition was reduced in all 12 patients who could be evaluated. 12 of 27 patients ... The primary efficacy endpoint was a 20% reduction in the annual rate of telomere attrition measured. Toxic effects formed the ...

https://en.wikipedia.org/wiki/Danazol

When that chromosome subsequently replicates it forms two sister chromatids which both lack a telomere. Since telomeres appear ... Since the two resulting chromatids lack telomeres, when they replicate the BFB cycle will repeat, and will continue every ... The BFB cycle begins when the end region of a chromosome, called its telomere, breaks off. ... Murnane, John P. (2012). "Telomere dysfunction and chromosome instability". Mutation Research. 730 (1-2): 28-36. doi:10.1016/j. ...

https://en.wikipedia.org/wiki/Breakage-fusion-bridge_cycle

Jef Akst (2015). "Another Telomere-Regulating Enzyme Found". The Scientist (November 12). Kastan MB, Lim DS (2001). "The many ... and telomere maintenance. Therefore, a defect in ATM has severe consequences in repairing certain types of damage to DNA, and ... http://www.hprd.org/protein/06347 Drosophila telomere fusion - The Interactive Fly GeneReviews/NCBI/NIH/UW entry on Ataxia ...

https://en.wikipedia.org/wiki/ATM_serine/threonine_kinase

In plants, the telomere sequence is conserved which implies this strategy can be utilized to successfully construction ... Yu, W.; Lamb, J. C.; Han, F.; Birchler, J. A. (2006). "Telomere-mediated chromosomal truncation in maize". Proceedings of the ... The minimum constituent parts of a chromosome (centromere, telomere and DNA replication sequences) are assembled This is done ... A minichromosome is a small chromatin-like structure consisting of centromeres, telomeres and replication origins and little ...

https://en.wikipedia.org/wiki/Minichromosome

Telomeres form the terminal region of mammalian chromosomes and are essential for stability and aging and play central roles in ... Telomeres have been long considered transcriptionally inert DNA-protein complexes until it was recently shown that telomeric ... Although early, these studies suggest an involvement for telomeric ncRNAs in various aspects of telomere biology. In mouse ... These ncRNAs are heterogeneous in length, transcribed from several sub-telomeric loci and physically localise to telomeres. ...

https://en.wikipedia.org/wiki/Long_non-coding_RNA

Each time a cell in the body divides, its telomeres become shorter. Eventually, telomeres shorten to the point where the cell ... In humans, aging is strongly correlated with the length of an individual's telomeres, the repetitive DNA at the ends of each ... Are Telomeres the Key to Aging and Cancer?, The University of Utah, Genetic Science Learning Center, archived from the original ... Telomere Telomerase Shea, Steven. "History of Isagenix". Complete Life Wellness. Retrieved 19 July 2015. Geron Corp. Licensee ...

https://en.wikipedia.org/wiki/Sierra_Sciences

In recent years Blackburn and her colleagues have been investigating the effect of stress on telomerase and telomeres with ... Blackburn co-discovered telomerase, the enzyme that replenishes the telomere. For this work, she was awarded the 2009 Nobel ... Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a ... Intimate partner violence was found to shorten telomere length in formerly abused women versus never abused women, possibly ...

https://en.wikipedia.org/wiki/Elizabeth_Blackburn

The shrinking of telomeres occurs in somatic cells where telomerase, the enzyme in control of telomere lengthening, is not ... Another component of aging is the gradual shortening of telomeres located at the end of chromosomes. Telomeres are repetitive ... This increase in non-coding RNA transcription aided telomere stability, making the exercise group's telomeres less likely to be ... However, it has been seen that telomeres can transcribe non-coding RNA, or functional RNAs that do not get translated into ...

https://en.wikipedia.org/wiki/Epigenetics_of_physical_exercise

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme ... Telomerase are found specifically to target shorter telomere over longer telomere, due to various regulatory mechanisms inside ... Although cells with long telomeres did not experience apoptosis, they developed mortal characteristics and underwent telomere ... It elongates the telomeres of stem cells, which, as a consequence, increases the lifespan of the stem cells by allowing for ...

https://en.wikipedia.org/wiki/Telomerase_reverse_transcriptase

Ty5 is used as a model system by which to understand the biology of the telomere and heterochromatin. The Ty5 retrotransposon ... Pryde FE, Louis EJ (November 1997). "Saccharomyces cerevisiae telomeres. A review". Biochemistry Mosc. 62 (11): 1232-41. PMID ... which interact with specific cis DNA sequences at the telomeres, rDNA and HM loci. These proteins, including Rap1p and the ... "The Saccharomyces Ty5 retrotransposon family is associated with origins of DNA replication at the telomeres and the silent ...

https://en.wikipedia.org/wiki/Ty5_retrotransposon

S. pombe has a shelterin-like telomere complex while S. cerevisiae does not. S. cerevisiae is in the G1 phase of the cell cycle ... Price CM, Boltz KA, Chaiken MF, Stewart JA, Beilstein MA, Shippen DE (2010). "Evolution of CST function in telomere maintenance ... telomere function, gene splicing, and many other cellular processes. S. pombe's genome was fully sequenced in 2002, the sixth ...

https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe

1992). "Telomere length predicts replicative capacity of human fibroblasts". Proc. Natl. Acad. Sci. U.S.A. 89: 10114-10118. ... 1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346: 866-868. doi:10.1038/346866a0. PMID ... 1996). "Accelerated telomere shortening in ataxia telangiectasia". Nat. Genet. 13: 350-353. doi:10.1038/ng0796-350. Hastie ND, ... Frenck RW Jr, Blackburn EH, Shannon KM (1998). "The rate of telomere sequence loss in human leukocytes varies with age". Proc. ...

https://en.wikipedia.org/wiki/Stem_cell_theory_of_aging

Telomere. He is the protagonist of the story and a member of the Junior Leaguers. Not having powers, he focuses more on ... Telomere- Creator of Lil` Heroes Handbook. He can live for a very long time (currently 273 years old). He doesn't consider ... When the citizens of Superopolis begin rejecting Telomere's crispy potato chips for the bland-flavored Pseudo chips, the potato ...

https://en.wikipedia.org/wiki/Ordinary_Boy_(novel_series)

Zhang H, Cohen SN (Dec 2004). "Smurf2 up-regulation activates telomere-dependent senescence". Genes & Development. 18 (24): ...

https://en.wikipedia.org/wiki/SMURF2

T-loops and G-quadruplexes are described as the two tertiary DNA structures that protect telomere ends and regulate telomere ... CST protection of telomeres for mammals occurs under conditions of replication stress. But when not replicating DNA, mammals ... Lue NF, Zhou R, Chico L, Mao N, Steinberg-Neifach O, Ha T (2013). "The telomere capping complex CST has an unusual ... In fungus, the CST complex has been shown to unfold higher order G-tailed structures, such as occur with telomere exposure ...

https://en.wikipedia.org/wiki/CST_Complex

One hypothesis for the detrimental results of aging is associated with the loss of telomeres, the end segments of chromosomes ... Telomere loss has also been associated with decreased mitochondrial function. Deficiency of telomerase reverse transcriptase ( ... Therefore, the loss of telomeres and TERT that comes with aging has been associated with impaired mitochondrial biogenesis. ... Sahin, Ergün; DePinho, Ronald A. (2012-05-16). "Axis of ageing: telomeres, p53 and mitochondria". Nature Reviews. Molecular ...

https://en.wikipedia.org/wiki/Mitochondrial_biogenesis

van Overbeek M, de Lange T (2006). "Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S ... SNM1B/Apollo protein appears to be a crucial factor in telomere maintenance, independent of its function in repairing DNA inter ... Using an SNM1B/Apollo knockout mouse model, evidence was obtained that SNM1B/Apollo protein is required to protect telomeres ... Freibaum BD, Counter CM (2006). "hSnm1B is a novel telomere-associated protein". J. Biol. Chem. 281 (22): 15033-6. doi:10.1074/ ...

https://en.wikipedia.org/wiki/DCLRE1B

TRF1 along with TRF2 normally prevents telomerase from adding more telomere units to telomeres. But when telomere lengthening ... TRF2 (Telomere Repeat Factor 2) TRF2 is a homodimeric protein that binds to the double-stranded TTAGGG region of the telomere ... When telomeres are to be lengthened, TPP1 is a central factor in recruiting telomerase to telomeres. The gene which encodes for ... TRF1 (Telomere Repeat Factor 1): TRF1 is a homodimeric protein that binds to the double-stranded TTAGGG region of the telomere ...

https://en.wikipedia.org/wiki/Shelterin

Interestingly, telomere lengthening in cancer cells by the alternative lengthening of telomeres (ALT) mechanism has also been ... Telomeres maintain the integrity of the ends of linear chromosomes during replication and protect them from being recognized as ... MRN participates in telomere maintenance primarily via association with the TERF2 protein of the shelterin complex. Additional ... Additionally, knockdown of MRN has been shown to significantly reduce the length of the G-overhang at human telomere ends, ...

https://en.wikipedia.org/wiki/MRN_complex

... that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate ... Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene. This gene is a member of the ... "Entrez Gene: POT1 POT1 protection of telomeres 1 homolog (S. pombe)". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ... Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013-8. ...

https://en.wikipedia.org/wiki/POT1

A telomere is a region of repetitive sequences at each end of eukaryotic chromosomes in most eukaryotes. Telomeres protect the ... Telomerase reverses telomere shortening. Telomerase replaces short bits of DNA known as telomeres, which are otherwise ... Cherif H, Tarry JL, Ozanne SE, Hales CN (2003). "Ageing and telomeres: a study into organ- and gender-specific telomere ... A comparative biology study of mammalian telomeres indicated that telomere length of some mammalian species correlates ...

https://en.wikipedia.org/wiki/Telomerase

The counting device for cell doublings is the telomere, which decreases in size (loses nucleotides at the ends of chromosomes) ... About 85% of cancers upregulate telomerase to extend their telomeres and the remaining 15% use a method called the Alternative ... Cancer cells bypass this barrier by manipulating enzymes that increase the length of telomeres. Thus, they can divide ... Greenberg, RA (March 2005). "Telomeres, crisis and cancer". Current molecular medicine. 5 (2): 213-8. doi:10.2174/ ...

https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer

Telomere-associated DNA damage also increases in timeless depleted cells, along with the delay of telomere replication. Swi1 is ... 2012). "Timeless Preserves Telomere Length by Promoting Efficient DNA Replication through Human Telomeres". Cell Cycle. 11 (12 ... Downregulation of the timeless gene in human carcinoma cells leads to shortened telomeres, indicating its role in telomere ... This association between timeless and telomeres is indicative of the gene's possible association with cancer. A single ...

https://en.wikipedia.org/wiki/Timeless_(gene)

The lab's future work will focus more on identifying the processing and regulation of telomeres and telomere elongation. ... Greider chose to use RNA degrading enzymes and saw that the telomeres stopped extending, which was an indication that RNA was ... Hopkins "Telomere" expert Carol Greider shares Germany's largest science prize "Former Davis resident receives Nobel Prize". ... Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for ...

https://en.wikipedia.org/wiki/Carol_W._Greider

Banks, D. A. (1997). "Telomeres, Cancer, and Aging. Altering the Human Life Span". JAMA: The Journal of the American Medical ... Haussmann MF, Winkler DW, O'Reilly KM, Huntington CE, Nisbet IC, Vleck CM (2003). "Telomeres shorten more slowly in long-lived ... life span and number of double bonds Selected species of birds and mammals show an inverse relationship between telomere rate ...

https://en.wikipedia.org/wiki/Maximum_life_span

Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (December 2004). "Accelerated telomere shortening in ...

https://en.wikipedia.org/wiki/Perceived_Stress_Scale

... Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Wed Sep 25 10:36:35 EST 1996 *Previous ... the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. MCB 16: 2483- ... that appears to combine elements of intrachromatid recombination and pairing of non-homologous telomeres to regulate telomere ... POSTDOCTORAL POSITIONS AVAILABLE TO STUDY TELOMERE SIZE REGULATION AND TELOMERIC SILENCING IN SACCHAROMYCES CEREVISIAE. I am ...

http://www.bio.net/bionet/mm/yeast/1996-September/005803.html

Telomere length predicts replicative capacity of human fibroblasts. R C Allsopp, H Vaziri, C Patterson, S Goldstein, E V ... Telomere length predicts replicative capacity of human fibroblasts. R C Allsopp, H Vaziri, C Patterson, S Goldstein, E V ... Telomere length predicts replicative capacity of human fibroblasts. R C Allsopp, H Vaziri, C Patterson, S Goldstein, E V ... indicating that cell strains with shorter telomeres underwent significantly fewer doublings than those with longer telomeres. ...

https://www.pnas.org/content/89/21/10114?ijkey=6c7739c95503b834eb4c6ae5418269c1fa2477be&keytype2=tf_ipsecsha

This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can ... Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at ... In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity ... Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. ...

http://www.mdpi.com/2073-4425/8/2/55

Their behavior suggested that they carried functional telomeres. Here we show that efficient healing by de novo telomere ... Healing of Euchromatic Chromosome Breaks by Efficient de novo Telomere Addition in Drosophila melanogaster. Simon W. A. Titen ... Healing of Euchromatic Chromosome Breaks by Efficient de novo Telomere Addition in Drosophila melanogaster. Simon W. A. Titen ... Healing of Euchromatic Chromosome Breaks by Efficient de novo Telomere Addition in Drosophila melanogaster. Simon W. A. Titen ...

https://www.genetics.org/content/184/1/309.abstract

Two groups conclude that factors near telomeres alter the telomeres nuclear positioning and thus their length. ... The lengths of telomeres, which are caps for chromosome ends, are kept consistent by a pathway that "counts" the number of Rap1 ... Cells need a critical amount of it, but if they get too much then telomeres might get added anywhere a double-stranded DNA ... Her team shows that the anchoring of individual telomeres near the NE is variable and correlates with the composition of the ...

http://jcb.rupress.org/content/172/6/786

Telomere length shortens with age in all replicating somatic cells. It has been shown that tobacco smoking enhances telomere ... Telomere shortening in smokers with and without COPD. M. Morlá, X. Busquets, J. Pons, J. Sauleda, W. MacNee, A. G. N. Agustí ... Telomere shortening in smokers with and without COPD Message Subject (Your Name) has sent you a message from European ... Telomere length was determined by fluorescence in situ hybridisation in circulating lymphocytes harvested from 26 never-smokers ...

http://erj.ersjournals.com/content/27/3/525.short

While TERT maintains telomere length under standard conditions, telomeres under increased stress shorten as fast as in cells ... We also know that progressive telomere shortening is tied to aging and age-related disease, and a number of different groups ... There is also evidence for a telomere-independent survival function of telomerase. However, its mechanism is not understood. We ... More On Telomere Shortening and Mitochondrial Dysfunction. Permalink , No Comments Yet , Add a Comment , Share , Posted by ...

https://www.fightaging.org/archives/2008/06/more-on-telomere-shortening-and-mitochondrial-dysfunction/

This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere ... Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review). *Authors: *Persefoni Fragkiadaki ... A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. Therefore, ... OA and OP have been characterized as age‑related diseases and have been associated with telomere shortening and altered ...

https://www.spandidos-publications.com/10.3892/etm.2019.8370/abstract

Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human ... and it grew stronger with increasing intrapair difference in all telomere parameters. Leukocyte telomere dynamics might help ... Telomere length and mortality: a study of leukocytes in elderly Danish twins Kimura, M., Hjelmborg, J. v.B., Gardner, J., ... The proportions derived from the intrapair comparisons indicated that the shorter telomeres predicted the death of the first co ...

http://www.demogr.mpg.de/de/projekte_publikationen/publikationen_1904/zeitschriftenartikel/telomere_length_and_mortality_a_study_of_leukocytes_in_elderly_danish_twins_3279.htm

Telomere resolvase is an enzyme found in bacteria which contain linear plasmids. Linear plasmid contain hair pin turns at the ... Telomere resolvase then cuts the structure and reforms the hair pin turns forming two linear plasmids.. ...

https://en.wikipedia.org/wiki/Telomere_resolvase

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere ( ... insect morphology), a type of genital clasper Telomere resolvase, an enzyme found in bacteria which contain linear plasmids. ...

https://en.wikipedia.org/wiki/Telomere_(disambiguation)

... and terminal restriction fragment analysis have traditionally been regarded as the gold standard for measuring telomere length ... New study may offer a breakthrough in treating telomere diseases. *Crick study reveals vital protective role of telomere t- ... Approaches and challenges in studies of telomere length. When a research study wants to include telomere length in the analysis ... The length of the shortest telomere represents a much better indicator of cellular aging than the average telomere length, ...

https://www.news-medical.net/life-sciences/Telomere-Measurement.aspx

Telomeres become shorter every time a cell divides. Once they are too short, telomeres send a signal for the cell to stop ... New Insight into Telomere Regulation New Insight into Telomere Regulation * Prenatal Lead Exposure Linked with Decreased ... oxoG lesion arises in telomeres dictates whether telomerase is inhibited or stimulated and thus determines whether the telomere ... Research, funded in part by NIEHS, has uncovered new details about the regulation of telomeres. These repeated DNA sequences ...

https://www.niehs.nih.gov/research/supported/sep/2017/telomere-regulation/index.cfm

... and protection of telomeres 1 (POT1) - which are essential for telomere protection and for regulating telomere elongation. The ... a , Simplified schema of the haematopoiesis hierarchy with intact telomere length (left panel) and in the presence of telomere ... The telomere syndromes.. Armanios M1, Blackburn EH.. Author information. 1. Department of Oncology, Sidney Kimmel Comprehensive ... At every age, telomere length displays a normal distribution that is defined by the percentile lines labelled on the right. ...

https://www.ncbi.nlm.nih.gov/pubmed/22965356?dopt=Abstract

Telomere News and Research. RSS A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of ... Telomere shortening in adulthood is not caused by smoking, say researchers A new study suggests that telomere length in adults ... Study: Smoking does not shorten the length of telomeres A new study has surprised the medical world, finding that smoking does ... People born with short telomeres found to have short-lived immune system cells Scientists at Johns Hopkins say they have found ...

https://www.news-medical.net/?tag=/Telomere

The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized ...

http://www.uniprot.org/locations/SL-0276

... known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA ... Telomere Length Short Telomere Cajal Body Telomere Elongation Nonextendible State These keywords were added by machine and not ... Correct telomere length setting is crucial for long-term survival. The telomere length reserve must be sufficient to avoid ... In vivo analysis of telomere elongation kinetics shows that telomerase does not act on every telomere in each cell cycle but ...

https://link.springer.com/article/10.1007%2Fs00412-006-0067-3

... although telomere shortening may play a role in limiting cellular life span, there is no evidence that telomere shortening ... long-lived species often have shorter telomeres than do short-lived species, indicating that telomere length probably does not ... 56Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Commun. ... Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460. 54Vaziri H, Dragowska W, Allsopp RC, Thomas TE, ...

https://www.scientificamerican.com/article/telomeres/

The question remains whether Dollys short telomeres were an exception or a general fact, which would differ from the telomeres ... inherited shortened telomeres from her cell donor and that her telomeres were further shortened by the brief culture of donor ... This observation was challenged by a recent report9 that showed calves cloned from fetal cells have longer telomeres than their ... The question remains whether Dollys short telomeres were an exception or a general fact, which would differ from the telomeres ...

https://www.nature.com/articles/ng1100_272?error=cookies_not_supported&code=237927e4-0a7a-4786-8420-7131661f40c4

... rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere ... Cancer progression Cell growth Chromatin Genomics Model systems Protein interaction networks Proteomics Telomere DNA Telomere ... Telomeres and Telomerase: Methods and Protocols, Second Edition builds upon the telomerase assays featured in the popular first ... Authoritative and practical, Telomeres and Telomerase: Methods and Protocols, Second Edition serves as an ideal, up-to-date ...

https://link.springer.com/book/10.1007/978-1-61779-092-8

This newsletter may contain advertising, deals, or affiliate links. Subscribing to a newsletter indicates your consent to our Terms of Use and Privacy Policy. You may unsubscribe from the newsletter at any time ...

https://www.extremetech.com/tag/telomeres

... and telomere length implies that stress preceded telomere shortening, because telomere length cannot have influenced the number ... A) Average telomere length and SE are shown. The high-stress group had shorter telomeres even after controlling for age and BMI ... Therefore, in translating telomere shortening to years of aging, we based our estimates on studies averaging telomere ... Telomeres are DNA-protein complexes that cap chromosomal ends, promoting chromosomal stability. When cells divide, the telomere ...

https://www.pnas.org/content/101/49/17312

In human, the mode of telomere length inheritance appears to be paternal and telomere length differs between sexes, with ... To test the influence of sex chromosomes on telomere length, we investigated inheritance and sex-specificity of telomere length ... Inheritance of telomere length in a bird.. Horn T1, Robertson BC, Will M, Eason DK, Elliott GP, Gemmell NJ. ... with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is ...

https://www.ncbi.nlm.nih.gov/pubmed/21364951?dopt=Abstract

... those whose donor white blood cells had longer telomeres had higher survival rates five-years after transplant ... Donor telomere length and survival after hematopoietic cell transplantation in patients with severe aplastic anemia. * ... Telomere length has been implicated in the development of several cancers, as well as other health conditions. This study was ... Telomeres are complex structures on the ends of chromosomes that help maintain chromosome integrity. They shorten naturally as ...

https://www.cancer.gov/news-events/press-releases/2015/donor-telomere-length-saa

... collectively called a telomere. With each cell division, telomeres are copied and reassembled through a process called telomere ... I will use purified proteins to study telomere replication in a test tube. This novel approach will allow me to use biochemical ... My work will provide fundamental molecular insights into the biology of telomeres, which will help us better understand human ... Understanding the mechanism of telomere replication. Sir Henry Dale Fellowships Year of award: 2019 ...

https://wellcome.ac.uk/grant-funding/people-and-projects/grants-awarded/understanding-mechanism-telomere-replication

There is a correlation between diabetes and telomere shortening; however, very little is known about telomere homeostasis in ... There is a correlation between diabetes and telomere shortening; however, very little is known about telomere homeostasis in ... Telomere homeostasis in placentas from pregnancies with uncontrolled diabetes. *Biron-Shental T ... TERC gene copy number and telomere capture were evaluated by FISH. Results Telomerase expression was significantly lower in the ...

https://www.mendeley.com/catalogue/0d10b7ee-e212-3688-9d55-a0a88c6c28f9/

Cells age if the telomeres are shortened, but when "telomerase activity is high, telomere length is maintained, and cellular ... Americans Win Nobel for Telomere Discovery. - Three American scientists, whose research held the key to unlocking chromosome ... Blackburn and Szostak discovered that the solution to chromosome replication was contained in telomeres, the structure at the ... Greider was a graduate student when she and and Blackburn identified telomerase, the enzyme that makes telomere DNA. ...

https://www.medpagetoday.com/genetics/generalgenetics/16279

Telomere Dynamics Telomere overhang generation processes and the end-replication problem. Telomeres are composed of TTAGGG ... From previous studies, we found that telomere overhang generation processes may be important in determining telomere shortening ... We found that the telomere lagging strand has an overhang of ~110 nt and the leading strand has an overhang of ~30 nt. These ... If that were correct, the rate of telomere shortening would only be around 8-10 bp per cell division (RNA primer size ÷ 2 = (16 ...

https://www.utsouthwestern.edu/labs/shay/research/telomere-dynamics.html

Find telomere Stock Images in HD and millions of other royalty-free stock photos, illustrations, and vectors in the ... Telomere stock photos. 568 Telomere stock photos, vectors, and illustrations are available royalty-free. See telomere stock ... Telomeres DNA and telomere length medical concept on the end caps of a chromosome as a symbol for aging and genetic protection ... Telomeres length loss with DNA and shortening telomere medical concept as a tree with falling leaves on the end caps of a ...

https://www.shutterstock.com/search/telomere

telomeres Archive antiaging100 years ago the world absolute poverty rate was as bad as the poorest country today. No Comments ...

https://www.nextbigfuture.com/tag/telomeres

Postdoctoral position to study telomere structure and function. A postdoctoral position is available to investigate telomere ... telomeres at Tulane. Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Mon Mar 10 09:14:06 EST 1997 *Previous message: THE ... We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) ... The mechanisms of nucleation and inheritance of telomeric silencing (e.g. MCB 16: 2843); and 2) the mechanism of telomere size ...

http://www.bio.net/bionet/mm/biochrom/1997-March/001446.html

Observable: telomere length. Description. The average length of telomeres.. Qualifiers. decreased, increased, normal, abnormal ...

https://www.yeastgenome.org/observable/APO:0000144

Telomere and Telomerase. The safety and scientific validity of this study is the responsibility of the study sponsor and ...

https://clinicaltrials.gov/ct2/show/results/NCT01176422

Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also ... Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. ... This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and ... The pervasive role of magnesium in telomere homeostasis is also highlighted. ...

https://www.mdpi.com/1422-0067/19/1/157

This process shortens the telomeres or scalar antenna on the DNA which as they get shorter limits the ability to grow new cells ... We use the Viopulsar for activating the amazing Telomerase enzyme and the Telomeres. Facial: 2-3 sessions weekly Set the SWL on ... scientists have recently discovered an enzyme called the Telomerase enzyme which increases the length of the telomere thereby ... and the violet laser spectrum optimizes and enhances this quantum rejuvenation effect of activating Telomerase and the Telomere ...

https://www.scribd.com/document/77602687/Scalar-Wave-Laser-Protocol-Manual

Schematic overview depicting either (A) shorter inherited telomere length (TL), or (B) accelerated telomere attrition (ΔTL), as ... telomeres versus (2) higher telomere attrition rates (Figure). The study provides evidence supporting the first hypothesis. In ... Telomeres and Atherosclerosis. The Intricate Pursuit of Mechanistic Insight Through Epidemiology. Tim De Meyer, Marc L. De ... These studies demonstrated that telomeres-typically measured in the DNA isolated from blood cells-clearly shorten with age. On ...

http://hyper.ahajournals.org/content/70/2/243

It has long been presumed impossible to measure telomeres in vertebrate DNA by PCR amplification with oligonucleotide primers ... Telomere measurement by quantitative PCR Nucleic Acids Res. 2002 May 15;30(10):e47. doi: 10.1093/nar/30.10.e47. ... Here we present a primer pair that eliminates this problem, allowing simple and rapid measurement of telomeres in a closed tube ... This assay will facilitate investigations of the biology of telomeres and the roles they play in the molecular pathophysiology ...

https://pubmed.ncbi.nlm.nih.gov/12000852/?dopt=Abstract

In contrast, telomeres from sperm DNA did not decrease with age of the donor, suggesting that a mechanism for maintaining telomere length, such as telomerase expression, may be active in germ-line tissue. (pnas.org)

We also found that fibroblasts from Hutchinson-Gilford progeria donors had short telomeres, consistent with their reduced division potential in vitro. (pnas.org)
This lengthening did not occur in nullizygotes, and short telomeres inherited from mTert null parents were rescued only in heterozygous progeny. (biologists.org)
Here, a germline missense mutation of MDM4 , a negative regulator of p53, was found in a family with features suggestive of dyskeratosis congenita, e.g., bone marrow hypocellularity, short telomeres, tongue squamous cell carcinoma, and acute myeloid leukemia. (sciencemag.org)

OA and OP have been characterized as age‑related diseases and have been associated with telomere shortening and altered telomerase activity (TA). (spandidos-publications.com)
We studied Tert expression patterns, telomerase activity, cytosolic reactive oxygen species (ROS) production, and telomere length in fresh oocytes from young versus reproductively-aged female mice retrieved from oviducts at 14 h post-human chorionic gonadotropin (hCG), in vivo or in vitro postovulatory-aged mouse oocytes at 23 h post-hCG. (biomedcentral.com)
Telomerase activity was measured by a telomeric repeat amplification protocol assay, while telomere length was measured by Q-PCR and quantitative fluorescence in situ hybridization analyses. (biomedcentral.com)
Long-term adverse effects of low telomerase activity and increased ROS exposure are likely associated with telomere shortening in oocytes from reproductively-aged female mice. (biomedcentral.com)
In patients who have received hematopoietic stem cell transplantation (HSCT), the telomere length and the telomerase activity of the engrafted donor cells have a significant influence on HSCT outcomes. (biomedcentral.com)
Because clinical observations suggest that leukemic cells accumulate at different rates, we measured telomere length and telomerase activity in B-CLL cells to distinguish differences in cellular replication. (elsevier.com)
Leukemic cells of the immunoglobulin V gene mutation subgroups differ in telomere length and telomerase activity. (elsevier.com)
B lymphocytes from the subgroup with poor outcome and with limited IgV gene mutations have uniformly shorter telomeres and more telomerase activity than those from the subgroup with better outcome and with considerable mutations. (elsevier.com)

Telomere addition by telomerase does not occur at every telomere in each cell cycle, yet an equilibrium average length is often maintained, with longer telomeres exhibiting a decreased propensity for elongation compared with shorter telomeres ( Hug and Lingner, 2006 ). (biologists.org)
Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. (ox.ac.uk)
Here we discuss the way in which HR contributes to telomere protection and elongation in mammalian cells. (ox.ac.uk)
Est1A/SMG6 controls telomere elongation by mediating telomerase recruitment. (uni-ulm.de)
Moreover, we found that TERT localization at telomeres is maintained all through spermatogenesis as a structural component without affecting telomere elongation. (unipv.it)

Because we had previously shown that telomeres, the terminal guanine-rich sequences of chromosomes, shorten throughout the life-span of cultured cells, we wished to determine whether variation in initial telomere length would account for the unexplained variation in replicative capacity. (pnas.org)
In this thesis, the levels of these modifications were studied in telomeric chromatin and in the telomere adjacent chromatin of the short arm of the human sex chromosomes (XpYp) in a panel of six human cell lines utilising different telomere maintenance mechanisms. (le.ac.uk)
Telomeres are nucleoprotein complexes at the ends of chromosomes and consist of tandem arrays of short repetitive sequences (TTAGGG in humans) and a set of specialized proteins ( 1-3 ). (aacrjournals.org)
As caps at the ends of chromosomes, telomeres play a critical role in protecting chromosomes from degradation, end-to-end fusion, abnormal recombination, and other detrimental chromosomal events ( 4, 5 ). (aacrjournals.org)
Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and degradation. (biomedcentral.com)
The telomeres are specific nucleoprotein structures at the ends of eukaryotic chromosomes which maintain genome stability by protecting chromosomes from end fusion and degradation. (biomedcentral.com)
Telomeres are ribonucleoprotein structures at the end of chromosomes composed of telomeric DNA, specific-binding proteins and noncoding RNA (TERRA). (unipv.it)

Recently, knockout mouse cell lines have indicated that epigenetic modifications associated with telomeric and subtelomeric chromatin, including DNA methylation, Histone 3 Lysine 9 (H31K9) trimethylation and Histone 4 Lysine 20 (H4K20) trimethylation, play an important role in influencing the choice of telomere maintenance mechanism. (le.ac.uk)
While telomeric DNA is mostly double-stranded, telomeres terminate with a single-stranded GT-rich 3′ overhang, known as G-tail. (prolekare.cz)
Telomere length was measured by quantitative polymerase chain reaction from blood and expressed as the amount of telomeric genomic DNA to the beta-globin gene (T/S ratio). (edu.au)
Importantly, our data show that telomere integrity is impacted by heat shock and that telomeric DNA damages are markedly enhanced in HSF1 deficient cells. (uclouvain.be)
Telomeric Repeat-Containing RNA (TERRA) and Telomerase Are Components of Telomeres During Mammalian Gametogenesis. (unipv.it)
While both TERRA levels and distribution would be regulated in a gender-specific manner, telomere-TERT co-localization appears to be regulated based on species-specific characteristics of the telomeric structure. (unipv.it)
Recently, a high-profile study reported a negative birth-cohort effect on leukocyte mean telomere length in human populations, namely the progressive loss of telomeric sequence between healthy human generations. (biomedcentral.com)

Many proteins cooperate to establish and maintain telomere integrity and replication in mammals ( de Lange, 2005 ). (biologists.org)
In mammalian cells, double-stranded DNA (dsDNA)-specific telomere binding proteins are encoded by TRF1 and TRF2 and a single-stranded DNA (ssDNA)-specific telomere binding protein is encoded by POT1, and together with RAP1, TIN2 and TPP1, they form a telomere protection complex known as "shelterin" [4] . (prolekare.cz)
Significantly shortened telomeres, activation of telomerase, and altered expression of telomere-associated proteins are common features of various hematologic malignancies and are related with progression or chemotherapy resistance in these diseases. (biomedcentral.com)
cells defective in the recombinational repair proteins RAD51D or RAD54 exhibit telomere shortening and end-to-end chromosome fusions. (ox.ac.uk)

Telomeres are the protective caps of eukaryotic chromosome ends and are known to shorten in the dividing cells of somatic tissues of higher animals during aging, in contrast to telomeres in the germline, which have been thought to remain stable in a species. (biomedcentral.com)

When telomere lengths become critically short, the process of cell senescence is initiated, resulting in cell-cycle arrest or apoptosis in normal cells ( 9 ). (aacrjournals.org)
As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. (biomedcentral.com)

The mouse has proven to be a valuable model with which to dissect the role of telomere attrition in cellular proliferation and disease. (biologists.org)
Importantly, our longitudinal analyses revealed a positive relationship between initial TL and telomere attrition rate within individual lizards i.e. lizards with short initial telomeres were subjected to reduced telomere attrition rates compared to lizards with long initial TL. (wildgenesgroup.com)
It has been suggested that there is a relationship between telomere attrition in the early stages of carcinogenesis and activation of the DNA damage response machinery. (elsevier.com)

Recent work has linked psychological stress with premature cellular aging as indexed by reduced leukocyte telomere length. (cardiffmet.ac.uk)
Yet, several research groups have reported the surprising findings of longer telomeres in the germ cells of older men, which translated into longer leukocyte telomere length in their offspring. (biomedcentral.com)

Telomerase replenishes telomere sequences that are lost during end processing and replication through its telomere polymerisation activity at single-stranded guanine (G)-rich overhangs, conferred by the telomerase reverse transcriptase (TERT) and the reverse transcription of an internal RNA component (TER, or TERC) ( Hug and Lingner, 2006 ). (biologists.org)
However, evidence suggests that elongated telomeres can prevent loss of subtelomeric DNA methylation associated with replication in normal human cells. (le.ac.uk)
Thus, we investigated how loss of Poz1, Rap1 and Taz1 affects cell cycle regulation of Ccq1 Thr93 phosphorylation and telomere association of telomerase (Trt1 TERT ), DNA polymerases, Replication Protein A (RPA) complex, Rad3 ATR -Rad26 ATRIP checkpoint kinase complex, Tel1 ATM kinase, shelterin subunits (Tpz1, Ccq1 and Poz1) and Stn1. (prolekare.cz)
In somatic cells under normal physiologic conditions, telomeres are progressively eroded by about 30 to 200 bp because of the end-replication problem during each mitotic cell division ( 6 ). (aacrjournals.org)

Dyskeratosis congenita is a cancer-prone inherited bone marrow failure syndrome caused by telomere dysfunction. (sciencemag.org)
Our data indicate that a germline activation of the p53 pathway may cause telomere dysfunction and point to polymorphisms affecting this pathway as potential genetic modifiers of telomere biology and bone marrow function. (sciencemag.org)
Given that telomere shortening in Est1 knockout tissues is not associated with telomere dysfunction or an activation of DNA damage checkpoints, these results suggests that loss of NMD function leads to selective toxicity in HSCs but not in other stem cell compartments. (uni-ulm.de)

Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere repeats, or by the Alternative Lengthening of Telomeres (ALT) mechanism, which is recombination based. (le.ac.uk)

This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. (spandidos-publications.com)

The shelterin complex in fission yeast consists of Taz1 (TRF1/TRF2 ortholog) that specifically recognizes double-stranded telomeres, the G-tail binding protein Pot1, Tpz1 (TPP1 ortholog), Rap1, Poz1 and Ccq1. (prolekare.cz)

While TERT maintains telomere length under standard conditions, telomeres under increased stress shorten as fast as in cells without active telomerase. (fightaging.org)

We show that prolonged mTert heterozygosity (for greater than ten generations) did not elicit disease, even upon heterozygote interbreeding, and that telomeres reset to wild-type lengths. (biologists.org)
Finally, telomere lengths were long in 38.9% and very short in 38.9% of breast carcinomas (P = 0.0087 for comparisons with preneoplastic lesions). (elsevier.com)
Welders had marginally shorter average telomere lengths than the administrative workers (p=0.058). (ncku.edu.tw)

Studies in fission yeast have previously identified evolutionarily conserved shelterin and Stn1-Ten1 complexes, and established Rad3 ATR /Tel1 ATM -dependent phosphorylation of the shelterin subunit Ccq1 at Thr93 as the critical post-translational modification for telomerase recruitment to telomeres. (prolekare.cz)
These analyses established that fission yeast shelterin maintains telomere length homeostasis by coordinating the differential arrival of leading (Polε) and lagging (Polα) strand DNA polymerases at telomeres to modulate Rad3 ATR association, Ccq1 Thr93 phosphorylation and telomerase recruitment. (prolekare.cz)
Mutations that affect shelterin or telomerase function in mammalian cells could lead to diseases that show premature aging due to depletion of the stem cell population, highlighting the importance to understand the regulatory mechanisms that ensure stable telomere maintenance [5] . (prolekare.cz)
Identification of a telomere protection complex that closely resembles mammalian shelterin [6] , coupled with the amenability to detailed genetic and molecular analysis, have made fission yeast Schizosaccharomyces pombe an attractive model organism to study telomere maintenance [7] . (prolekare.cz)
Telomerase is recruited to the telomere via its interaction with shelterin. (biomedcentral.com)

Here, we provide evidence that both TERRA and the telomerase enzymatic subunit (TERT) are components of telomeres in mammalian germ cells. (unipv.it)

In eukaryotic cells, dynamic cell cycle-regulated protein-DNA complexes formed at telomeres play key roles in the maintenance of genome stability [1] , [2] . (prolekare.cz)

Thus, gradual telomere erosion in the presence of telomerase may enable subsequent telomere extension, similar to that described in budding yeast. (biologists.org)

for example, life stress and oxidative stress may accelerate telomere shortening ( 7, 8 ). (aacrjournals.org)

The relative length of each specific telomere is defined in the zygote, determined by inherited factors, and maintained throughout life, but average telomere length shortens with increasing age ( 24-26 ). (aacrjournals.org)

This study aimed to ascertain the mechanisms underlying altered telomere biology in mouse oocytes during reproductive and postovulatory aging. (biomedcentral.com)
Understanding the mechanisms by which HR promotes telomere maintenance has important implications for genomic stability and tumorigenesis. (ox.ac.uk)
Context: Chronic psychological stress has been associated with shorter telomeres in some studies, but the underlying mechanisms are poorly understood. (cardiffmet.ac.uk)

the murine genes are hereafter referred to as mTerc and mTert , respectively), the eventual loss of telomere DNA leads to end-to-end fusions and defects in many tissues and progenitor cell compartments, including the blood, skin, intestine and germline ( Blasco, 2005 ). (biologists.org)

We found that TERRA co-localizes with telomeres during mammalian meiosis and that its expression progressively increases during spermatogenesis, until the beginning of spermiogenesis. (unipv.it)
Our results represent the first evidences of co-localization between telomerase and telomeres during mammalian gametogenesis. (unipv.it)

Transplantation-related factors should be taken into consideration because of their impacts on telomere homeostasis. (biomedcentral.com)

Additionally, the level of chromatin modifications associated with binding of 53BP1 was not affected by the telomere maintenance mechanism used in human cell lines. (le.ac.uk)

In addition, both Cdc13 and Stn1 were found to be involved in the regulation of telomere length, mutations in STN1 or CDC13 conferring an increase in telomere size. (scripps.edu)

Here, we observe that the function of HSF1 extends to telomeres and identify subtelomeric DNA as a new genomic target of HSF1. (uclouvain.be)

P = 0.004), indicating that cell strains with shorter telomeres underwent significantly fewer doublings than those with longer telomeres. (pnas.org)
P = 0.025), consistent with the correlation of this variant allele with longer telomeres. (aacrjournals.org)
Longer telomeres in the somatic cells of an individual have been regarded as a marker of youth and biological fitness within a population. (biomedcentral.com)

A mouse model recently suggested that p53 regulates telomere metabolism, but the clinical relevance of this finding remained uncertain. (sciencemag.org)

Autosomal dominant mutations in telomere-associated factors elicit a disease known as dyskeratosis congenita (DKC), and patients suffer proliferative abnormalities associated with telomere erosion. (biologists.org)
Similarly, the reported increase in the variability of telomere length in the spermatozoa of older men [ 5 ] can be easily explained by the lifelong mitotic activity of several populations of germ stem cells, which are exposed to environmental insults and subject to all kinds of errors, analogous to the increasing burden of acquired mutations in the spermatocytes of aging men. (biomedcentral.com)

This is in place of the more expected path of undoing ongoing telomere shortening by adding extra repeat sequences to the end of the telomeres - that being the better understood function of telomerase. (fightaging.org)

You might recall that researchers have put forward evidence to suggest that telomere shortening is caused by accumulated damage to mitochondrial DNA - essentially collapsing two areas of intense interest for gerontologists down to one root cause, if confirmed. (fightaging.org)
We also know that progressive telomere shortening is tied to aging and age-related disease, and a number of different groups are working on strategies to safely lengthen telomeres. (fightaging.org)
Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise human cells. (fightaging.org)
So, poorly functioning mitochondria lead to telomere shortening, and telomerase somehow improves mitochondrial function to prevent that shortening. (fightaging.org)
A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. (spandidos-publications.com)
We further investigated how telomere shortening, caused by trt1Δ or catalytically dead Trt1-D743A, affects cell cycle-regulated telomere association of telomerase and DNA polymerases. (prolekare.cz)
Telomere shortening is associated with the risk of many aging-related diseases. (aacrjournals.org)
Telomere shortening has been associated with aging and many aging-related diseases including cancer ( 6 , 10-12 ). (aacrjournals.org)
In tumor cells, the shortening of telomeres length is accelerated under the increased proliferation pressure. (biomedcentral.com)
Cre-mediated deletion of mEst1A in adult mice led to telomere shortening in small intestine comparable to the first generation of TERC deficient mice. (uni-ulm.de)
The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. (ncku.edu.tw)

These observations suggest that telomere length is a biomarker of somatic cell aging in humans and are consistent with a causal role for telomere loss in this process. (pnas.org)
In normal somatic cells, the length of the telomeres gradually becomes shortened with cell division. (biomedcentral.com)

The mean telomere length in peripheral blood leukocytes was measured by quantitative real-time PCR. (aacrjournals.org)

No evidence of association was seen for adult FEV1 or FVC, or any childhood spirometric index after adjustments.Conclusion:Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid-life adults. (edu.au)

Relative telomere length (RTL) was remarkably shorter in oocytes from reproductively-aged females compared to oocytes from young females. (biomedcentral.com)

Subtelomeric DNA methylation in the mouse has been shown to have a dynamic relationship with telomere length. (le.ac.uk)

Telomeres play a critical role in maintaining genome integrity. (aacrjournals.org)

Telomeres in preneoplastic lesions were more frequently shorter than those in normal tissues (P = 0.0116). (elsevier.com)

Anatomy6

Organisms3

Diseases5

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes18

Information Science8

Named Groups1

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. (1/4834)

A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. (2/4834)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (3/4834)

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (4/4834)

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. (5/4834)

Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis. (6/4834)

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. (7/4834)

Generation and characterization of human smooth muscle cell lines derived from atherosclerotic plaque. (8/4834)

Telomere

Telomere Homeostasis

Telomerase

Telomere-Binding Proteins

Telomeric Repeat Binding Protein 1

Telomeric Repeat Binding Protein 2

Cell Aging

In Situ Hybridization, Fluorescence

Dyskeratosis Congenita

Tankyrases

G-Quadruplexes

Oxytricha

Chromosomal Instability

Chromosomes, Fungal

Leukocytes

DNA-Binding Proteins

Repetitive Sequences, Nucleic Acid

Saccharomyces cerevisiae Proteins

Saccharomyces cerevisiae

DNA Damage

Genomic Instability

Mutation

Chromosomes

Aging

RNA

Euplotes

Blotting, Southern

DNA

Silent Information Regulator Proteins, Saccharomyces cerevisiae

DNA, Fungal

Base Sequence

Exodeoxyribonucleases

Chromosomes, Human

Antigens, Nuclear

Chromosome Aberrations

Recombination, Genetic

Aging, Premature

DNA Replication

Molecular Sequence Data

Cell Cycle Proteins

Rad52 DNA Repair and Recombination Protein

DNA Repair

RecQ Helicases

Fibroblasts

Tissue Donors

PubMed

Periodicals as Topic

Books

Publishing

MEDLINE

Serial Publications

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. (1/4834)

A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. (2/4834)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (3/4834)

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. (4/4834)

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. (5/4834)

Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis. (6/4834)

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. (7/4834)

Generation and characterization of human smooth muscle cell lines derived from atherosclerotic plaque. (8/4834)

Types, stability, and phenotypic consequences of chromosome rearrangements leading to interstitial telomeric sequences. |...

Prostate Cancer Cell Telomere Length Variability and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and...

Healing of Euchromatic Chromosome Breaks by Efficient de novo Telomere Addition in Drosophila melanogaster | Genetics

Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition | Genome...

Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects

Brunel University Research Archive: Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic...

A Genome-Wide Association Study Identifies a Locus on Chromosome 14q21 as a Predictor of Leukocyte Telomere Length and as a...

Leicester Research Archive: Investigation of epigenetic alterations related to telomere maintenance in human cells

Positive and negative regulation of telomerase access to the telomere | Journal of Cell Science

Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance | Science

Aging | Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging - Figure

Aging | Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging - Figure

Computel: computation of mean telomere length from whole-genome next-generation sequencing data.

Telomerase update -arguments for and against using telomere extender supplements - AGINGSCIENCES™ - Anti-Aging Firewalls™

Maternal pre-pregnancy body mass index and newborn telomere length | BMC Medicine | Full Text

The paradox of longer sperm telomeres in older mens testes: a birth-cohort effect caused by transgenerational telomere erosion...

Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells |...

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells | Molecular Cancer...

Papel de los Telomeric repeat-containing RNA (TERRA) en la biología del telómero y en pluripotencia mediado por la proteína...

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. - Department of Oncology

Genes | Free Full-Text | Solving the Telomere Replication Problem