Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Drug-Eluting Stents: Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Plant Poisoning: Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.Tubulin Modulators: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Chromium Alloys: Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Prince Edward Island: An island in the Gulf of St. Lawrence constituting a province of Canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is Charlottetown. Discovered by the French in 1534 and originally named Ile Saint-Jean, it was renamed in 1799 in honor of Prince Edward, fourth son of George III and future father of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p981 & Room, Brewer's Dictionary of Names, 1992, p433)New South Wales: A state in southeastern Australia. Its capital is Sydney. It was discovered by Captain Cook in 1770 and first settled at Botany Bay by marines and convicts in 1788. It was named by Captain Cook who thought its coastline resembled that of South Wales. (From Webster's New Geographical Dictionary, 1988, p840 & Room, Brewer's Dictionary of Names, 1992, p377)Turner Syndrome: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Embryology: The study of the development of an organism during the embryonic and fetal stages of life.Documentation: Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.Sanitary Engineering: A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.Bathing Beaches: Beaches, both natural and man-made, used for bathing and other activities.Hawks: Common name for many members of the FALCONIFORMES order, family Accipitridae, generally smaller than EAGLES, and containing short, rounded wings and a long tail.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)ParisRestaurantsWater: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Public-Private Sector Partnerships: An organizational enterprise between a public sector agency, federal, state or local, and a private sector entity. Skills and assets of each sector are shared to deliver a service or facility for the benefit or use of the general public.Coxsackie and Adenovirus Receptor-Like Membrane Protein: An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.Investments: Use for articles on the investing of funds for income or profit.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Adenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.FloridaDeer: The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)Nitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.Physalis: A plant genus of the family SOLANACEAE. Members contain physalin and withangulatin.Entomophthorales: An order of fungi comprising mostly insect pathogens, though some infect mammals including humans. Strict host specificity make these fungi a focus of many biological control studies.Pinus: A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. They are evergreen trees mainly in temperate climates.Nigeria: A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.Transportation: The means of moving persons, animals, goods, or materials from one place to another.Appointments and Schedules: The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.Amyloid beta-Protein Precursor: A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.Prenatal Care: Care provided the pregnant woman in order to prevent complications, and decrease the incidence of maternal and prenatal mortality.Obstetrics and Gynecology Department, Hospital: Hospital department responsible for the administration and management of services provided for obstetric and gynecologic patients.Automobile Driving: The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.Cities: A large or important municipality of a country, usually a major metropolitan center.Travel: Aspects of health and disease related to travel.European Union: The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)Azospirillum brasilense: A species of motile, free-living, gram-negative bacteria that occur in the soil. They are aerobic or microaerophilic and are sometimes capable of nitrogen fixation.Archaeoglobales: An order of extremely thermophilic, sulfate-reducing archaea, in the kingdom EURYARCHAEOTA. The single family Archaeoglobaceae contains one genus ARCHAEOGLOBUS.Automobiles: A usually four-wheeled automotive vehicle designed for passenger transportation and commonly propelled by an internal-combustion engine using a volatile fuel. (Webster, 1973)Love: Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.BaltimorePhenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).Wind: The motion of air relative to the earth's surface.Neonatal Screening: The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.Blood Specimen Collection: The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

New taxane diterpenoid from seed of the Chinese yew, Taxus yunnanensis. (1/79)

A novel taxane diterpenoid with a rearranged 5/7/6-membered ring system was isolated from seeds of the Chinese yew, Taxus yunnanensis. Its structure was established as 9alpha,13alpha-diacetoxy-10beta-benzoxy-5alpha- cinnamoyl-11(1 5-->1)-abeotaxa-4(20),11-dien-15-ol on the basis of a spectroscopic analysis. Its relative stereochemistry is proposed from the results of NOESY experiments.  (+info)

Two novel taxane diterpenoids from the needles of Japanese yew, Taxus cuspidata. (2/79)

Two novel taxane diterpenoids were isolated from the needles of Japanese yew, Taxus cuspidata, and their structures were determined to be lbeta-hydroxy-7beta-acetoxytaxinine (1) and lbeta,7beta-dihydroxytaxinine (2) on the basis of spectral analyses including 2D-NMR studies.  (+info)

Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. (3/79)

A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistance protein (MRP)-mediated multidrug resistance. BTK reversed the resistance to paclitaxel, doxorubicin (ADM), and vincristine (VCR) of KB-8-5 and KB-C2 cells that overexpress P-gp by directly interacting with P-gp. BTK also moderately reversed the resistance to ADM of KB/MRP cells that overexpress MRP. However, BTK neither inhibited the transporting activity of MRP nor reduced intracellular glutathione levels in KB/MRP cells. BTK shifted the distribution of ADM in KB/MRP cells from punctate cytoplasmic compartments to the nucleoplasm and cytoplasm by inhibiting acidification of cytoplasmic organelles. These two functions of BTK make it able to reverse both P-gp- and MRP-mediated MDR. BTK in combination with ADM should be useful for treating patients with tumors that overexpress both P-gp and MRP.  (+info)

Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. (4/79)

BACKGROUND: The committed step in the biosynthesis of the anticancer drug taxol in yew (Taxus) species is the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene. The enzyme taxadiene synthase catalyzes this complex olefin cation cyclization cascade involving the formation of three rings and three stereogenic centers. RESULTS: Recombinant taxadiene synthase was incubated with specifically deuterated substrates, and the mechanism of cyclization was probed using MS and NMR analyses of the products to define the crucial hydrogen migration and terminating deprotonation steps. The electrophilic cyclization involves the ionization of the diphosphate with closure of the A-ring, followed by a unique intramolecular transfer of the C11 proton to the re-face of C7 to promote closure of the B/C-ring juncture, and cascade termination by proton elimination from the beta-face of C5. CONCLUSIONS: These findings provide insight into the molecular architecture of the first dedicated step of taxol biosynthesis that creates the taxane carbon skeleton, and they have broad implications for the general mechanistic capability of the large family of terpenoid cyclization enzymes.  (+info)

New 11(15-->1)abeotaxane, 11(15-->1),11(10-->9)bisabeotaxane and 3,11-cyclotaxanes from Taxus yunnanensis. (5/79)

Chemical examination of the seeds of Chinese yew, Taxus yunnanensis Cheng et L. K. Fu resulted in the isolation of an 11(15-->1)abeotaxane, an 11(15-->1), 11(10-->9)bisabeotaxane and two 3,11-cyclotaxanes. The structures of these new taxoids were established as 13alpha-acetoxy-5alpha-cinnamoyloxy-11(15-->1)abeotaxa-4(20),11-diene-9alpha,10be ta,15-triol (1), 20-acetoxy-2alpha-benzoyloxy-4alpha, 5alpha, 7beta, 9alpha, 13alpha-pentahydroxy-11(15-->1), 11(10-->9) bisabeotax-11-eno-10,15-lactone (2), 2alpha,10beta-diacetoxy-5alpha-cinnamoyloxy-9alpha-hydroxy-3,11 -cyclotax-4(20)-en-13-one (3) and 10beta-acetoxy-2alpha,5alpha,9alpha-trihydroxy-3,11-cyclotax-4(20)-en-13-one (4) on the basis of spectral analyses.  (+info)

Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase. (6/79)

A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that are considered to be mediated by cytochrome P450-dependent monooxygenases. A PCR-based differential display-cloning approach, using Taxus (yew) cells induced for Taxol production, yielded a family of related cytochrome P450 genes, one of which was assigned as a taxane 10 beta-hydroxylase by functional expression in yeast. The acquired clones that did not function in yeast were heterologously expressed by using the Spodoptera fugiperda-baculovirus-based system and were screened for catalytic capability by using taxa-4(20),11(12)-dien-5 alpha-ol and its acetate ester as test substrates. This approach allowed identification of one of the cytochrome P450 clones (which bore 63% deduced sequence identity to the aforementioned taxane 10 beta-hydroxylase) as a taxane 13 alpha-hydroxylase by chromatographic and spectrometric characterization of the corresponding recombinant enzyme product. The demonstration of a second relevant hydroxylase from the induced family of cytochrome P450 genes validates this strategy for elucidating the oxygenation steps of taxane diterpenoid (taxoid) metabolism. Additionally, substrate specificity studies with the available cytochrome P450 hydroxylases now indicate that there is likely more than one biosynthetic route to Taxol in yew species.  (+info)

New taxane diterpenoids from the roots of Taiwanese Taxus mairei. (7/79)

Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of Taiwanese Taxus mairei (LEMEE & LEVL.) S. Y. Hu. Compounds 1-4 belong to the new 11(15-->1)-abeo-taxene system, having a tetrahydrofuran ring along carbons C-2, C-3, C-4 and C-20. Compounds 3 and 4 contain an isopropenyl group at C-1 while compounds 1 and 2 are attached with a benzoxyl group at C-15. The structures of compounds 1-5 were determined on the basis of two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.  (+info)

The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. (8/79)

The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases. Several full-length acyltransferase sequences, obtained from a cDNA library constructed from mRNA isolated from Taxus cuspidata cells induced for Taxol production with methyl jasmonate, were individually expressed in Escherichia coli, from which a cDNA clone encoding a 3'-N-debenzoyl- 2'-deoxytaxol N-benzoyltransferase was identified. This recombinant enzyme catalyzes the stereoselective coupling of the surrogate substrate N-debenzoyl-(3'RS)-2'-deoxytaxol with benzoyl-CoA to form predominantly one 3'-epimer of 2'-deoxytaxol. The product 2'-deoxytaxol was confirmed by radio-HPLC,(1)H-NMR, and chemical ionization-MS. This enzymatic reaction constitutes the final acylation in the Taxol biosynthetic pathway. The full-length cDNA coding for the N-benzoyltransferase has an ORF of 1,323 nucleotides and encodes a 441-residue protein with a calculated molecular weight of 49,040. The recombinant enzyme expressed in E. coli has a pH optimum at 8.0, a k(cat) approximately 1.5 +/- 0.3 s(-1) and K(m) values of 0.42 mM and 0.40 mM for the N-deacylated taxoid and benzoyl-CoA, respectively. In addition to improving the production yields of Taxol in genetically engineered host systems, this enzyme provides a means of attaching modified aroyl groups to taxoid precursors for the purpose of improving drug efficacy.  (+info)

  • Sales of Boston Scientific Corp. 's Taxus drug-eluting stent line fell 25 percent during the three months ended June 30, according to a detailed earnings report filed with the Securities and Exchange Commission. (massdevice.com)
  • MINNEAPOLIS--( BUSINESS WIRE )-- The Resolute ® drug-eluting stent (DES) from Medtronic, Inc. (NYSE: MDT), showed superiority to Boston Scientific Corp.'s Taxus ® DES on the primary endpoint of the RESOLUTE Japan clinical study: in-stent late lumen loss at eight months. (fiercehealthcare.com)
  • The primary endpoint of RESOLUTE Japan compared 100 patients treated with the Resolute DES to a historical control - specifically, eight-month in-stent late lumen loss for 135 patients in the ENDEAVOR IV clinical trial who received a Taxus DES. (fiercehealthcare.com)
  • In the cell culture of Taxus chinensis, Taxuyunnanine C (Tc) is the primary taxoid. (edu.au)
  • Following the construction of an antisense RNA expression vector of 14OH from Taxus chinensis , the antisense 14OH cDNA (as 14OH ) was introduced into TM3 cells by Agrobacterium tumefaciens -mediated transformation. (up.edu)
  • Taxus suspension cell culture has the potential to provide a sustainable source of anticancer drug paclitaxel (Taxol ® ) and other taxoids. (edu.au)
  • These results indicated that the antisense RNA strategy is a useful tool in suppressing the expression of genes in Taxus and this method could be used to silence other important genes that divert Taxol pathway to side-route metabolites. (up.edu)
  • Included in that increase, however, was a $22 million "returns reserve adjustment" the company took during the second quarter of 2008 to compensate for the planned transition from the Taxus Express2 to the second-generation Taxus Liberté. (massdevice.com)
  • Taxus Cardium Pharmaceuticals Group Inc CRXM Pharmaceuticals Healthcare Deals and Alliances Profile provides you comprehensive data and trend analysis of the company's Mergers and Acquisitions MAs, partnerships and financings. (bioportfolio.com)
  • The yew, aka Taxus spp , is a tree / shrub that grows predominatly in wet , temperate climates. (everything2.com)
  • To suppress taxoid 14β- hydroxylase gene ( 14OH ) expression in the Taxus × media TM3 cell line, antisense RNA inhibition approach was used in this study. (up.edu)
  • and Qui, De-You, "Antisense-induced suppression of taxoid 14β-hydroxylase gene expression in transgenic Taxus × media cells" (2011). (up.edu)
  • Southern blot analysis of hygromycin phosphotransferase gene (HYG) revealed that this selection gene was integrated successfully into the genome of Taxus × media cells. (up.edu)
  • Wikimedia Commons prepausa de documents multimèdia liures sus Taxus . (wikipedia.org)
  • Taxus is a genus of small coniferous trees or shrubs in the yew family Taxaceae. (wikipedia.org)
  • Known to botanists as the conifer genus Taxus or yew, there is current consensus that there are eight species worldwide, occurring on various continents and in diverse climates. (mountauburn.org)
  • Taxus x × media , whenever you see the letter × between the genus ( Taxus ) and species ( media ) of a plant name that identifies this as a plant which had parentage from two different species, referred to as a hybrid. (mountauburn.org)
  • Other potential rivals include crowd-funded eVolo, a firm based near Mannheim that has said it expects to receive special regulatory approval for its two-seat "multicopter" with 18 rotors to be used as flying taxis in pilot projects by 2018. (ndtv.com)
  • Earlier this month Nissan unveiled its update of New York City's most iconic moving public space: the Taxi, only a year after New York City Taxi and Limousine Commission selected the automaker, after an extremely competitive two-year bid selection process. (metropolismag.com)
  • Understanding that the NYC Taxi is a major element of the city's brand, the design team gave the brand the face-lift it deserves. (metropolismag.com)
  • The first bomb blew up at 1:05 p.m. yesterday in one of the city's trademark yellow-and-black taxis, which was parked at an intersection in the Mumba Devi neighborhood. (baltimoresun.com)
  • Hong Kong - Hong Kong saw its first electric taxis hit the streets on Saturday in a step towards reducing the city's high levels of roadside pollution. (news24.com)
  • Shanghai's transportation authority also plans to enlist the city's taxi dispatch centers to supervise and regulate taxi-hailing apps. (chinadaily.com.cn)
  • During a visit to Mbandaka, the AP attended a workshop run by the government and the World Health Organization for 300 of the city's estimated 4,000 taxi drivers. (morningjournal.com)
  • Earlier this year, the city's Taxi and Limousine Commission said there are 545 money-grubbing hacks who pulled off the scam between 50 and 499 times - and a disturbing 88 who did it more than 500 times. (villagevoice.com)
  • London Taxi will get you home or to work or wherever you need to be with a just click to hail a private car directly from your location. (apple.com)
  • You can specify an 8 seater, estate or just a normal saloon to take you away and in spite it being called London Taxi, this app is not just restricted to London. (apple.com)
  • Let London Taxi take you securely, economically and comfortably to your destination. (apple.com)
  • London Taxi comes from the makers of the most downloaded London Commuter app ever, London Tube Map (so you know you're in safe hands! (apple.com)
  • The new Austin FX4 was not just the first London taxi to be fitted with four doors for, together with the Routemaster bus, it was symbolic of post-war change in the capital. (telegraph.co.uk)
  • He is a pretty bad taxi driver, unsure of the routes to well-known Tehran landmarks and less than diligent about collecting fares and delivering customers to their destinations. (miamiherald.com)
  • Taxi fares are basically made up of a starting fee and then a per-kilometre charge (listed here). (inyourpocket.com)
  • Taxi Booking is suitable for - Metered taxi services, Limo and Private hire pre-booked fixed fares, Hourly car hire, Shuttle and Bus ticket sales. (joomla.org)
  • The six-day strike had left commuters stranded across the country, with taxis taking only emergency fares for disabled people or those needing to get to hospitals, and led to scuffles in Rome as protesters clashed with police. (thestar.com.my)
  • Santaco's highest decision-making body‚ Management Council (Manco)‚ has decided at its specially convened meeting that taxi fares for local and long-distance operations will increase‚" the organisation said. (timeslive.co.za)
  • B MC had developed a replacement model, codenamed ADO39, but this was cancelled following the company's merger with Leyland, and the now virtually iconic taxi would have to continue in production for several more years. (telegraph.co.uk)
  • Keep your hand raised until a taxi driver spots you and pull over. (wikihow.com)
  • Make eye contact with the driver when your taxi pulls over. (wikihow.com)
  • Once your driver has stopped, approach the taxi and make direct eye contact as you do so. (wikihow.com)
  • Open the backseat door and enter the taxi, where you can tell the driver your destination. (wikihow.com)
  • All he needed was a taxi and the driver to go with it. (fanfiction.net)
  • Johannesburg - A taxi driver who had been using somebody else's name on his licence was cornered and arrested in Ivory Park, east of Johannesburg on Wednesday. (news24.com)
  • The taxi driver turned out to be a licenceless Mozambican national who had been passing himself off as Ringani for years. (news24.com)
  • The team approached the product design of the Taxi by considering the passenger and the driver. (metropolismag.com)
  • A taxi licence in Rome is worth €150,000 (RM704,794), but the NCC pays ten times less elsewhere," said Gabriele, 52, who has been a taxi driver since 2011 and did not want to give his surname. (thestar.com.my)
  • We are a public service and we're independent while they're defending multi-nationals,' said taxi driver Marta Fernandez, 42, during the protest which shut off traffic for at least two hours. (voanews.com)
  • Lal Sahab Singh, a taxi driver whose white clothes were spotted with blood, was yards away when the bomb exploded. (baltimoresun.com)
  • Malele said the driver carried a responsibility to ensure the taxi was disinfected, riders sanitised and ensure the windows were semi-ajar, and this would ensure there was accountability all around to ensure commuters and drivers were safe when commuting. (iol.co.za)
  • The driver will also shut the door when you leave the taxi. (hubpages.com)
  • A New York City taxi driver who fatally struck a pedestrian in Manhattan in November had been working more than 15 hours. (wsj.com)
  • Officers took the two into custody after seeing that the pair was wanted on a variety of criminal offenses but let taxi driver Abdullah Sönmez go, according to reports. (hurriyetdailynews.com)
  • Not long ago there were reports of a taxi driver taking an Arab tourist from Kadıköy on the Asian side of the city, over the Bosphorus Bridge to the European side, and back over the bridge to the Sabiha Gökçen Airport on the Asian side. (hurriyetdailynews.com)
  • In another report, a taxi driver was accused of trying to kick out the husband and kidnap his wife. (hurriyetdailynews.com)
  • A taxi driver who was embroiled in a road rage incident punched a motorcyclist so severely that it left him with a permanent eye injury. (yahoo.com)
  • A motorcycle taxi driver carries a passenger through the streets of Mbandaka, Congo. (morningjournal.com)
  • Despite his worries, the taxi driver in Mbandaka city never presented himself to health officials, who are vaccinating everyone who's had direct contact with a sick person and then contacts of those people, too. (morningjournal.com)
  • Jens Stoltenberg: Norway's prime minister works as taxi driver for afternoon. (slate.com)
  • In what he described as an effort to hear from real Norwegians, Stoltenberg dressed up as a taxi driver and spent an afternoon driving people around Oslo. (slate.com)
  • Why did you decide to become a licensed taxi driver, instead of just a taxi passenger? (seriouseats.com)
  • After the November 15th Metropolitan Transit System Taxicab Advisory Committee (MTS-TAC) election, the 800-member strong taxi driver association plans to once again bring up the issue of lease fees through their new elected representatives. (kpbs.org)
  • Mathematicians at the MIT CSAIL computer lab have developed a new algorithm they say could eliminate allow 3000 carpooling vehicles to do the work of 14,000 taxis. (gas2.org)
  • Among travelers caught up in the chaos was U.S. rock singer Courtney Love, widow of late Nirvana lead singer Kurt Cobain, who wrote in a Tweet appeal to the French president that her car had come under siege by protesting taxi drivers. (reuters.com)
  • In concept, Water Taxi Beach is similar to Paris Beach in Paris , France . (wikipedia.org)
  • Taxis drivers block a highway outside Paris, as they take part in a demonstration to protest against the growing number of minicabs, known in France as Voitures de Tourisme avec Chauffeurs (VTC). (sfgate.com)
  • Taxi drivers in London, Paris and other European capitals. (sfgate.com)
  • A yellow ribbon reading "Taxi on strike" is seen on a Paris taxi which is taking part in a demonstration near the Eiffel Tower, in Paris, on Wednesday. (sfgate.com)
  • PARIS (Reuters) - France ordered a nationwide clampdown on UberPOP on Thursday, siding with taxi drivers who blockaded major transport hubs in angry protests against the popular online ride-sharing service. (reuters.com)
  • Creative ways to beat city traffic are always appreciated, and Paris is taking it to the next level with new flying water taxis. (matadornetwork.com)
  • If near field communication (NFC) technology can be used to help commuters pay for their bus journeys in Paris , then why not let taxi patrons in Taiwan use it to book their next ride? (springwise.com)
  • This Taxi Booking App app allow the users to get a safe, reliable and classy rides with the simple taps. (slideshare.net)
  • Taxi apps are those apps which allows the users to get a safe, reliable and classy rides with the fingertips of their hands. (slideshare.net)
  • It's a win for the young startup, especially in light of the TLC's on-again, off-again battles with e-hailing services and the recent kibosh it put on another sharing service, SideCar, which used private vehicles, not taxis, to provide shared rides. (crainsnewyork.com)
  • He tested his sense that people would be motivated to share rides by trying to hand out dollar bills to travelers at the head of the taxi line at Penn Station if they would stand aside for a few minutes and not take the next cab. (crainsnewyork.com)
  • The latest taxi apps offer fast rides to the customers and help them to reach their destinations well in time. (selfgrowth.com)
  • The taxi apps also offer shared rides which enable them to cut down on expenses while at the same time get the best quality taxi services for their needs. (selfgrowth.com)
  • The number of taxi rides is growing - overwhelmingly so for people in poor neighborhoods - as fire officials wrestle with more calls and limited resources. (azcentral.com)
  • The number of taxi calls by Phoenix fire has grown steadily in recent years, both in numbers and in percentage of taxi rides compared with all dispatches. (azcentral.com)
  • The researchers used data from over 3 million NYC taxi rides to create a simulation of an average day for taxi drivers. (popularmechanics.com)
  • The beach concept was created in 2005 as an experiment in community and economic development by New York Water Taxi to attract Manhattanites to Long Island City and to make weekend ferries serving the new residential high-rises near the beach financially viable. (wikipedia.org)
  • As a result, many taxi drivers cruise the streets with their eye on a collection of cell phones dotted on their dashboards running various apps while searching for big-ticket bids, which poses potential safety hazards. (chinadaily.com.cn)
  • 2. Vice-President and President of Taxi Industry Services Association, respectively. (google.com)
  • Many people took the operating companies' offer to trade-in their cars and invest in taxis and PRT services for which they get a big discount. (google.com)
  • Launch your own Nigeria taxi booking app for transportation services. (slideshare.net)
  • The fledgling union for Chicago's taxi drivers complained, citing an ordinance barring anyone but taxicabs and limousine services from serving the airports. (nytimes.com)
  • Taxi drivers hold a banner during a strike action in protest of unliscensed taxi-type-services in Barcelona on Wednesday. (sfgate.com)
  • With Taxi Booking Light you can start selling your transportation services on your website in minutes. (joomla.org)
  • Founded in 2002, New York Water Taxi has continuously expanded its routes and increased its fleet while delivering spectacular views for a price that shames the car services. (nymag.com)
  • More than a thousand Spanish taxi drivers blocked a central Madrid boulevard on Thursday, beeping horns and setting off firecrackers, to protest plans to open the country to greater competition from ride-hailing and car-sharing services. (voanews.com)
  • SHANGHAI, Feb 9 (Reuters) - Chinese ride hailing giant Didi Chuxing will set up a venture with SoftBank Group Corp to provide ride-hailing and other services for the Japanese taxi industry, the companies said in a statement on Friday. (reuters.com)
  • There are also plans to look at potential routes for the proposed water taxi services, he added. (thefreedictionary.com)
  • Munich-based Lilium, backed by investors who include Skype co-founder Niklas Zennstrom, said the planned five-seater jet, which will be capable of vertical take-off and landing, could be used for urban air taxi and ride-sharing services. (ndtv.com)
  • Such factors have certainly increased the demand for the services that are offered by taxi app development companies. (selfgrowth.com)
  • Here are some of the reasons why companies looking to be a part of online taxi booking services are currently using the expertise offered by the taxi app development firms. (selfgrowth.com)
  • Most of the taxi apps are light, easy to use and deliver fast services which has enabled them to become very popular within a short time. (selfgrowth.com)
  • The best thing about taxi apps is that both the consumers and taxi drivers are on the same page when it comes to their services as well as the prices that they need to pay for a ride. (selfgrowth.com)
  • When you're ready to hail a taxi, stand at the edge of the sidewalk away from oncoming cars. (wikihow.com)
  • If you make it easy for drivers to see you, you will hail a taxi faster. (wikihow.com)
  • Ask at your hotel for help to write the location to where you want to go, then go hail a taxi on the street, as it will be cheaper than booking one. (hubpages.com)
  • Slackening the rules would pitch the heavily-regulated taxi sector, which requires licenses and closely monitored quality and safety controls, against untested drivers which operate with little, or no, restrictions, taxi unions say. (voanews.com)
  • The jet, whose power consumption per km is comparable to an electric car, could offer passenger flights at prices comparable to normal taxis but with speeds five times faster, Lilium said. (ndtv.com)
  • Water Taxi Beach was an artificial temporary beach operated from 2005 to 2010 on a wharf on the East River in the Hunters Point section of Long Island City , in the New York City borough of Queens . (wikipedia.org)
  • There are taxis in Cortona, but they don't just roam around like in a large city such as Rome. (tripadvisor.co.uk)
  • Eager to reverse the trend, taxi drivers in Chicago and other cities are for the first time seeking to form a national taxi drivers' union - not just to gain leverage against UberX but also to pressure city officials and taxi companies to heed their concerns. (nytimes.com)
  • The powerful taxi drivers' union in New York City, with 17,000 members, is spearheading this effort, bringing its organizing expertise to Chicago, where it is pushing to unionize thousands of drivers and to link up with drivers' unions in Philadelphia, Miami, Houston, northern Maryland and Austin, Tex. (nytimes.com)
  • One snag these unionization plans face is that taxi drivers are usually independent contractors who are barred by antitrust law from colluding to set prices (although they can lobby city officials to grant fare increases). (nytimes.com)
  • One recent Sunday afternoon, three leaders of the New York City Taxi Workers Alliance met with 10 Chicago taxi drivers on Chicago's North Side to strategize about expanding the union here and trying to halt UberX's expansion. (nytimes.com)
  • South Korea's transport ministry and Seoul City conducted a test-run of a drone taxi - capable of carrying two people, with a demonstration in Seoul on Wednesday. (reuters.com)
  • The new Taxi will start appearing on New York City roads on October 31, 2013. (metropolismag.com)
  • I've hailed my fair share of taxis in New York City, which are mostly Crown Victorias. (gas2.org)
  • Cabdrivers crusaded yesterday to get the city to add a surcharge to taxi meters to offset rising gas prices. (nypost.com)
  • He called for more charging stations around the city to encourage taxi drivers to go electric - BYD said it is setting up 47 chargers in nine charging locations near car parks. (news24.com)
  • Summary: New Delhi [India], June 26 (ANI): Minister of State for Shipping, Mansukh Mandaviya on Wednesday inspected the Sonia Vihar site for proposed Yamuna Water Taxi Project of Inland Waterways Authority of India (IWAI) here said that the project will boost tourism in a sustainable way and reduce traffic congestion in the city. (thefreedictionary.com)
  • OKLAHOMA CITY Boathouse Foundation Executive Director Mike Knopp and Bricktown Water Taxi General Manager Chad Huntington have been talking for several years about connecting their two areas. (thefreedictionary.com)
  • The City of Memphis has landed an $800,000 U.S. Department of Transportation grant to put water taxis in the Mississippi River but convincing city officials to come up with a 20 percent match for the project could be a tough sell, The Commercial Appeal reports . (bizjournals.com)
  • These distinctive blue Toyotas are the most common taxis in the city, as well as the most reputable. (travbuddy.com)
  • Hundreds are being vaccinated in Congo's deadly Ebola outbreak, but busy taxi drivers who might be ferrying the sick in an infected city of more than 1 million argue they are on the front lines as well and should receive the vaccine. (morningjournal.com)
  • Propped against his motorcycle taxi outside a hospital in the city affected by Congo's latest deadly Ebola outbreak, Jean Cedric waved a hand in the air, showing his fear about the risks of his job. (morningjournal.com)
  • With few cars in the vibrant city on the Congo River, the majority of residents rely on motorcycle taxis as their primary mode of transport. (morningjournal.com)
  • Taxi vouchers are paid for by the city and cost a fraction of an ambulance ride. (azcentral.com)
  • Thanks to them, I stumbled upon some wonderful off-the-radar spots (I haven't found a steak that's come close since), but I wanted to see how the taxi adventures would translate in a city where drivers, and food, come from all over the world. (seriouseats.com)
  • Owing to mobility demand, the concept of bike taxi is gaining popularity in India. (slideshare.net)
  • BOMBAY, India - Two powerful bombs concealed in parked taxis exploded yesterday in the heart of Bombay, India's commercial capital, killing 45 people and wounding at least 135. (baltimoresun.com)
  • However, taxis are often the only way of getting around after midnight because trains and buses have stopped. (hubpages.com)
  • In the mean time please do not forget to ask yourself, how the taxi mafia managed to silence and sabotage far too many inquiries and outcomes mentioned in The Power of the Taxi Mafia and in the Sydney Morning Herald! (google.com)
  • Your first time riding in a taxi can be a little confusing. (wikihow.com)
  • This allows taxi drivers to know where potential customers are in real time. (acer.com)
  • This time the terrorists used taxis, and last time they used scooters. (baltimoresun.com)
  • You can choose the Time and place from where you want to borrow the taxi. (issuu.com)
  • There's also a time charge if the speed drops below 10km/h, or if the taxi stops. (hubpages.com)
  • The very idea behind the whole business is to merging mobile applications with traditional taxi business so that customers can book taxis online any time they want. (selfgrowth.com)
  • One of the main reasons why taxi apps have become so much popular in such a short time is that they make use of the best quality app development technologies in order to create apps which can be extremely useful to the consumers. (selfgrowth.com)
  • Our company looking for a group of team build taxi software web application , and hosted on our server , also we need written for the program manual technical user ,give support plus maintenance for managing Development must complete in frame time 7-8 weeks with test etc. (freelancer.com)
  • The algorithm can even predict areas where taxi usage will be high in the future, and send taxis to that area ahead of time for faster pickups. (popularmechanics.com)
  • For the first time, taxi drivers will get representation on a committee that advises the Metropolitan Transit System on taxi regulations. (kpbs.org)
  • Toyota Motor's Japan Taxi, born in a government committee and designed to be an all-things-to-all-people cab, has become a high-priced icon of Tokyo's budget-busting 2020 Olympic and Paralympic Games. (japantimes.co.jp)
  • Taxis are expensive, so don't use them unless you are with 3 other people to share the costs and you are trying to out run a tsunami. (hubpages.com)
  • Taxis are used by millions of people all around the world and they are widely preferred due to the simple and hassle-free traveling experience that they can provide. (selfgrowth.com)
  • Even today, taxi transportation forms an essential component of the regular public conveyance modes that are used by various people. (selfgrowth.com)
  • A taxi company app can not only make it easier for people to find taxis even during the busy hours of the day but it can also render it much easier and convenient. (selfgrowth.com)
  • They are particularly useful for people who tend to use taxis on a frequent basis. (selfgrowth.com)
  • Gone are the days when people had to stand in long queues in order to find the taxi that they are looking for. (selfgrowth.com)
  • Fwelo told the all-male group that she saw too many taxi drivers "die from fever" during the much larger West Africa outbreak four years ago that killed more than 11,000 people in Guinea, Liberia and Sierra Leone. (morningjournal.com)
  • She took a communal taxi via Liberia's capital Monrovia, exposing five other people to the virus who later contracted and died of the Ebola. (foxnews.com)
  • On the Greek island of Zakynthos (population approximately 35,000), at least 600 people (including taxi drivers and recreational hunters) have falsely registered themselves as blind and are collecting disability payments (of at least 350 euros, about $462, per month) from Greece's cash-strapped government. (care2.com)
  • We don't care if it is a NYC yellow cab, a London black cab or a Havanna Coco Taxi as long as it's a taxi and there is blur in the image. (dpreview.com)
  • Mobile taxi-booking apps have currently posed as a major edge for the traditional taxi business. (selfgrowth.com)
  • Taxi is full of wry jokes, surprising incidents and allusions to Mr. Panahi's earlier work. (miamiherald.com)
  • Taxi , though, happens to be the work of a great one, one of the most humane and imaginative practitioners of the art currently working. (miamiherald.com)
  • This is a payment plugin to accept Credit Cards through Authorize.net This payment plugin is for Taxi Booking extension for Joomla and will not work on it's own or for any other extension. (joomla.org)
  • But she had urged them to find a way to return to work, saying "the taxi drivers are a calling card for tourists and foreigners" stranded at airports, stations and hotels. (thestar.com.my)
  • How Stafford Taxis Work? (issuu.com)
  • Effective from March 1, taxi drivers that reject roadside hailing customers are subject to fines worth 200 yuan ($32) and 15 days' suspension of their work permit. (chinadaily.com.cn)
  • But if parliament doesn't work on this issue and the justice system hands down a different ruling [not in favor of the taxi drivers], our patience will have run out. (hurriyetdailynews.com)
  • Furthermore, if you're not familiar with Jakarta it's always best to take the BlueBird because not all taxis are trustworthy (and sometimes not even safe). (travbuddy.com)
  • S ixty years ago, sales commenced of a taxi so radical in design that not a few cabbies in the capital regarded it with a degree of suspicion. (telegraph.co.uk)
  • 4. Features of taxi app  Easy Login and Registration  User-friendly interface  Multiple languages  Multiple currencies  Flexible payment options  Reviews and feedback  Customer care support etc. (slideshare.net)
  • Mamabolo said monitoring would be done by the taxi association leaders and government officials deployed to ranks. (iol.co.za)
  • He said the marshals and managers would be trained and monitored to ensure the whole operation was above board, such as ensuring they adhered to what is required on the app, and there will be government officials to oversee that this happens as well as taxi industry co-ordinators to add support. (iol.co.za)
  • While officials say that anyone, including taxi drivers, who have had contact with an Ebola case or with one of those contacts will be vaccinated, the drivers are harder to track down because they're always on the move. (morningjournal.com)
  • A partnership between Nokia and Taiwan Taxi enables those with NFC-enabled phones to use that technology to book their next ride. (springwise.com)
  • That, indeed, is now possible thanks to a partnership between Nokia and Taiwan Taxi. (springwise.com)
  • The A.F.L.-C.I.O. supports the idea of a national taxi drivers' union as part of its broader strategy to reverse decades of decline in union membership and power. (nytimes.com)
  • National Taxi Alliance spokesperson Theo Malele said they were elated that the government had come in to reinforce the management in the taxi industry to ensure all commuting masses were safe when using transport. (iol.co.za)
  • The South African National Taxi Council (Santaco) has announced taxi fare increases between R1 and R10 for local trips and R1 to R20 for long distance journeys from August 1. (timeslive.co.za)
  • It's definitely a United Nations," said Karen Chamberlain, who has driven a taxi in Chicago for two decades. (nytimes.com)
  • The Nissan design, the NV200 Taxi, is the result of a research-driven and cross-disciplinary collaboration of The Cooper-Hewitt National Design Museum , the Design Trust for Public Space , and Smart Design . (metropolismag.com)
  • They do not want to ride old taxis driven by rude drivers anymore. (hurriyetdailynews.com)
  • Thailand introduced the law in 2005 to regulate Two-wheelers taxi and become the first country in the world to do so. (slideshare.net)
  • Taxi Booking Light is a lightweight version of the famous Taxi Booking for Joomla extension. (joomla.org)
  • Taxi Booking Light has the same front end booking form as Taxi Booking for Joomla, as well as a back-end management panel for Cars, Settings and Orders. (joomla.org)
  • From the creators of Taxi Booking for Joomla here is Share Cost - crowdfunding for Joomla. (joomla.org)
  • More stringent measures to ensure compliance with lockdown regulations in taxi ranks have been introduced. (iol.co.za)
  • Commuter Maureen Peta said this calmed down commuters who were feeling unsettled, and showed some seriousness to ensure ranks and taxis were not areas of danger as they had to use them daily as numbers go up in infections. (iol.co.za)