An ester of AMPICILLIN which is readily hydrolyzed on absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin.
Chronic nonsuppurative inflammation of periapical tissue resulting from irritation following pulp disease or endodontic treatment.
Pivalate ester analog of AMPICILLIN.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Kinetics of talampicillin decomposition in solutions. (1/6)

Talampicillin stability in aqueous solutions was studied in a broad range of pH values using as medium solutions of hydrochloric acid (pH 0.4-1.8), phosphate buffers (pH 2.05-3.13 and 6.03-8.04), acetate buffer (pH 3.87-5.28) and borate buffer (pH 8.90-9.10) as well as sodium hydroxide solution (pH 11.48). For the determination of talampicillin concentration changes in kinetic studies, two methods were used: iodometric and spectrophotometric in UV (lambda(max) = 254.5 nm). The catalytic velocity constants (k(H+), k(x), k(o)) were established, the log k-pH profile (35 degrees C) was found, thermodynamic parameters were calculated of the hydrolysis reaction of the beta-lactam bond (k(H+): E(A)= 67.9 kJ mol(-1), delta S = -92.4 J K(-1) mol(-1), delta G = 92.6 kJ mol(-1); k(x): E(A) = 31.8 kJ mol(-1), delta S = -347.1 J K(-1) mol(-1), delta G = 131.1 kJ mol(-1); k(o), pH = 5.28: E(A) = 98.0 kJ mol(-1), delta S = -50.3 J K(-1) mol(-1), delta G = 110.3 kJ mol(-1) at 20 degrees C), and the stability of the lactone bond was studied in the medium with the highest stability of beta-lactam bond of talampicillin (pH 5.28: k(o): E(A)= 32.5 kJ mol(-1), delta S = -220.5 J K(-1) mol(-1), delta G = 94.7 kJ mol(-1) in 20 degrees C), at controlled ionic strength (mu = 0.5 mol l(-1)).  (+info)

BRL.8988 (talampicillin), a well-absorbed oral form of ampicillin. (2/6)

The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.  (+info)

Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin. (3/6)

Ampicillin concentrations in human serum and dental granulomas of 31 patients were determined after a single oral dose of talampicillin (equivalent to 500 mg of ampicillin) was administered to each. The specimens were taken at 1.5, 2.0, 2.5, 3.0, and 3.5 h after the administration of talampicillin. The mean peak ampicillin concentrations in serum and dental granulomas occurred at identical times, 2.5 h, and were 8.29 micrograms/ml (range, 1.81 to 13.20 micrograms/ml) and 2.94 micrograms/g (range, 1.14 to 7.16 micrograms/g), respectively. The mean dental granuloma/serum ampicillin concentration ratio at the peak time (2.5 h) was 0.42 (range, 0.29 to 0.56). Ampicillin concentrations in dental granulomas exceeded most of the MICs for the bacteria commonly isolated from odontogenic infection.  (+info)

Talampicillin and probenecid compared with ampicillin and probenecid for the treatment of gonococcal urethritis in men. (4/6)

Two hundred and ten men suffering from uncomplicated gonococcal urethritis were treated with one of two treatment schedules. Of 109 patients treated with 3 g ampicillin and 2 g probenecid (group A) there were two recurrences in the first week after treatment and none in the second week. Of 101 patients treated with 1.5 g talampicillin and 2 g probenecid (group B), there were three recurrences in the first week and none in the second week. Both antibiotics were well tolerated, but one patient vomited two hours after taking talampicillin. The sensitivity pattern of Neisseria gonorrhoeae to penicillin at The London Hospital has shown an increase in the proportion of more sensitive strains during the last three years. Talampicillin given in a single dose with probenecid is satisfactory in the treatment of acute gonococcal urethritis but, apart from the smaller dosage, it does not offer any advantage over ampicillin with probenecid.  (+info)

Treatment of uncomplicated gonorrhoea in women with talampicillin in a single oral 1.5 g dose. (5/6)

Four hundred and sixty women with uncomplicated gonorrhea were treated with a single oral dose of 1.5 g talampicillin. The success rate among those who attended for at least one follow-up examination after treatment was 99.14%. The antibiotic was well tolerated and no side effects were reported. Talampicillin given under supervision has proved to be the most effective and safest treatment in this area. A smaller dosage of talampicillin than ampicillin is required, the drug is better tolerated by the patient, and the time of nursing staff is saved.  (+info)

Bioavailability of bacampicillin and talampicillin, two oral prodrugs of ampicillin. (6/6)

A 200-mg amount of bacampicillin showed a significantly higher relative extent of bioavailability than did a 250-mg amount of talampicillin, possibly due to their different stability in the digestive juices.  (+info)

I'm sorry for any confusion, but "Talampicillin" is not a recognized or established term in medical science or pharmacology. It's possible that there may be a spelling error or a mix-up with the names of various medications. Talampicillin does not appear in reputable databases of medical terms or drugs, such as those maintained by the World Health Organization (WHO), the US National Library of Medicine (NLM), or other reliable sources.

If you have any doubts about a specific medication or medical term, I would recommend checking these reputable sources or consulting with a healthcare professional to ensure you receive accurate and trustworthy information.

A periapical granuloma is a type of dental lesion that occurs at the root tip of a tooth (the apical region) in response to an infection in the pulp tissue. It is a collection of inflammatory cells, mainly composed of lymphocytes, plasma cells, and histiocytes, within the periodontal ligament and alveolar bone. The granuloma forms as a result of the body's attempt to contain the spread of infection from the pulp into the surrounding tissues.

The primary cause of periapical granulomas is untreated dental caries or tooth trauma, which allows bacteria to invade the pulp chamber and eventually reach the apical region. The resulting inflammation can lead to bone resorption and the formation of a radiolucent area around the apex of the affected tooth, visible on a dental radiograph.

Periapical granulomas may not always cause noticeable symptoms, but some patients might experience pain, swelling, or sensitivity in the affected tooth. Treatment typically involves root canal therapy to remove the infected pulp tissue and medicate the canals, followed by a filling or crown to seal and protect the tooth. In some cases, extraction of the tooth may be necessary if the infection is severe or if the tooth cannot be restored.

Pivampicillin is not a medication itself, but rather a prodrug of ampicillin, which is a type of antibiotic used to treat various bacterial infections. A prodrug is an inactive or less active form of a drug that is converted into its active form in the body after administration.

Pivampicillin is made up of ampicillin linked to a pivaloyl group, which helps improve the absorption and bioavailability of ampicillin when taken orally. Once absorbed, the pivaloyl group is removed by enzymes in the body, releasing ampicillin, which then exerts its antibacterial effects by inhibiting bacterial cell wall synthesis.

Therefore, a medical definition of pivampicillin would be: "A prodrug of ampicillin, used orally to treat various bacterial infections, which is rapidly converted to ampicillin in the body after administration."

Ampicillin is a penicillin-type antibiotic used to treat a wide range of bacterial infections. It works by interfering with the ability of bacteria to form cell walls, which are essential for their survival. This causes the bacterial cells to become unstable and eventually die.

The medical definition of Ampicillin is:

"A semi-synthetic penicillin antibiotic, derived from the Penicillium mold. It is used to treat a variety of infections caused by susceptible gram-positive and gram-negative bacteria. Ampicillin is effective against both aerobic and anaerobic organisms. It is commonly used to treat respiratory tract infections, urinary tract infections, meningitis, and endocarditis."

It's important to note that Ampicillin is not effective against infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or other bacteria that have developed resistance to penicillins. Additionally, overuse of antibiotics like Ampicillin can lead to the development of antibiotic resistance, which is a significant public health concern.

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae, also known as "gono" bacteria. It can infect various parts of the body including the genitals, rectum, and throat. The bacteria are typically transmitted through sexual contact with an infected person.

Symptoms may vary but often include abnormal discharge from the genitals or rectum, painful or burning sensations during urination, and in women, vaginal bleeding between periods. However, many people with gonorrhea do not develop symptoms, making it essential to get tested regularly if you are sexually active with multiple partners or have unprotected sex.

If left untreated, gonorrhea can lead to severe complications such as pelvic inflammatory disease (PID) in women and epididymitis in men, which may result in infertility. In rare cases, it can spread to the bloodstream and cause life-threatening conditions like sepsis.

Gonorrhea is curable with appropriate antibiotic treatment; however, drug-resistant strains of the bacteria have emerged, making accurate diagnosis and effective treatment increasingly challenging. Prevention methods include using condoms during sexual activity and practicing safe sex habits.

... is a beta lactam antibiotic from the penicillin family. It is an acid stable prodrug that was administered orally ... and one of these is talampicillin. One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine ... and the enamine was carefully hydrolyzed with dilute HCl in acetonitrile to produce talampicillin (4).[citation needed] Isaka I ...
... talampicillin MeSH D03.438.260.825.750.170 - carbenicillin MeSH D03.438.260.825.750.170.200 - carfecillin MeSH D03.438.260.825. ... talampicillin MeSH D03.605.084.737.750.170 - carbenicillin MeSH D03.605.084.737.750.170.200 - carfecillin MeSH D03.605.084.737. ...
... talampicillin (INN) talaporfin (INN) talarozole (USAN, INN) talastine (INN) talbutal (INN) taleranol (INN) talibegron (INN) ...
... talampicillin MeSH D02.065.589.099.750.750.170 - carbenicillin MeSH D02.065.589.099.750.750.170.200 - carfecillin MeSH D02.065. ...
Talampicillin Hetacillin (ampicillin conjugated to acetone) Epicillin is an aminopenicillin that has never seen widespread ...
J01CA10 Mezlocillin J01CA11 Mecillinam J01CA12 Piperacillin J01CA13 Ticarcillin J01CA14 Metampicillin J01CA15 Talampicillin ...
... talampicillin 1975 - tobramycin 1975 - bacampicillin 1975 - ticarcillin 1976 - amikacin 1977 - azlocillin 1977 - cefadroxil ...
Talampicillin is a beta lactam antibiotic from the penicillin family. It is an acid stable prodrug that was administered orally ... and one of these is talampicillin. One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine ... and the enamine was carefully hydrolyzed with dilute HCl in acetonitrile to produce talampicillin (4).[citation needed] Isaka I ...
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
Talampicillin and probenecid compared with ampicillin and probenecid for the treatment of gonococcal urethritis in men. (1 ...
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections.[1] While it is useful for many Gram negative infections, it is not useful for Gram positive infections.[1] It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled.[1] The injectable form is generally only used if other options are not available.[2] It is also available as the combinations bacitracin/polymyxin B and neomycin/polymyxin B/bacitracin for use on the skin.[3][4] Common side effects when given by injection include kidney problems, neurological problems, fever, itchiness, and rash.[1] Injections into muscle may result in significant pain.[1] Other serious side effects may include fungal infections, anaphylaxis, and muscle weakness.[1] It is unclear if use during pregnancy is safe for the baby.[1] Polymyxin B works by breaking down the cytoplasmic membrane which generally results in bacterial cell death.[1] ...
Hereditary coproporphyria is one of the porphyrias, a group of diseases that involves defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. Inheritance is autosomal (usually autosomal dominant, but sometimes autosomal recessive).
Talampicillin Talampicillin Hydrochloride use Talampicillin Talapoin Monkey use Cercopithecidae Talapoin Monkeys use ...
Talampicillin Talampicillin Hydrochloride use Talampicillin Talapoin Monkey use Cercopithecidae Talapoin Monkeys use ...
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
Talampicillin Talampicillin Hydrochloride use Talampicillin Talapoin Monkey use Cercopithecidae Talapoin Monkeys use ...
Talampicillin Talampicillin Hydrochloride use Talampicillin Talapoin Monkey use Cercopithecidae Talapoin Monkeys use ...
Talampicillin Talampicillin Hydrochloride use Talampicillin Talapoin Monkey use Cercopithecidae Talapoin Monkeys use ...
The discovery of penicillin is usually attributed to Scottish scientist Sir Alexander Fleming in 1928, though others had earlier noted the antibacterial effects of Penicillium. The development of penicillin for use as a medicine is attributed to the Australian Nobel Laureate Howard Walter Florey. In March 2000, doctors of the San Juan de Dios Hospital in San Jose (Costa Rica) published manuscripts belonging to the Costa Rican scientist and medical doctor Clodomiro (Clorito) Picado Twight (1887-1944). The manuscripts explained Picados experiences between 1915 and 1927 about the inhibitory actions of the fungi of genera Penic. Apparently Clorito Picado had reported his discovery to the Paris Academy of Sciences in Paris, yet did not patent it, even though his investigation had started years before Flemings. Fleming, at his laboratory in St. Marys Hospital (now one of Imperial Colleges teaching hospitals) in London, noticed a halo of inhibition of bacterial growth around a contaminant ...
Talampicillin. Sultamicillin. Azidocillin. Propicillin. Bacampicillin. Aspoxicillin. Clometocillin. Meticillin. Cell wall ...
Talampicillin Susc Islt 3 LOINC_Long_Common_Name LOINC Long Common Name Talampicillin [Susceptibility] ...
Talampicillin Hydrochloride. Synonym. (2S,5R,6R)-3-oxo-1,3-dihydroisobenzofuran-1-yl 6-((R)-2-amino-2-phenylacetamido)-3,3- ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
Talampicillin D2.886.675.966.500.750.750.50.900 D2.886.108.750.750.50.900. D4.75.80.875.99.221.750.750.50.900. Tea D20.215. ...
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Our molecular docking study showed four potential inhibitors against Mpro enzyme, two available drugs (Talampicillin and ...
TAL), ampicillin only (AMP) or both (AMP-TAL). Treatment was started two days after the onset of symptoms (experiment 1) and ...
20.000+ innovative pharmaceutical reference standards
Per The ICU Book "The first rule of antibiotics is to try not to use them, and the second rule is try not to use too many of them."[80] Inappropriate antibiotic treatment and overuse of antibiotics have contributed to the emergence of antibiotic-resistant bacteria. Self-prescribing of antibiotics is an example of misuse.[81] Many antibiotics are frequently prescribed to treat symptoms or diseases that do not respond to antibiotics or that are likely to resolve without treatment. Also, incorrect or suboptimal antibiotics are prescribed for certain bacterial infections.[23][81] The overuse of antibiotics, like penicillin and erythromycin, has been associated with emerging antibiotic resistance since the 1950s.[63][82] Widespread usage of antibiotics in hospitals has also been associated with increases in bacterial strains and species that no longer respond to treatment with the most common antibiotics.[82] Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in ...
20.000+ innovative pharmaceutical reference standards
InChI=1S/C17H17N7O8S4/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30)/b12-6-/t13?,15-,17+/m1/s1 ...

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