A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.
The L-isomer of Ofloxacin.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Six-membered heterocycles containing an oxygen and a nitrogen.
The giving of drugs, chemicals, or other substances by mouth.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
Substances that reduce the growth or reproduction of BACTERIA.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.
The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Hard or soft soluble containers used for the oral administration of medicine.
Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
Bacteria which retain the crystal violet stain when treated by Gram's method.
A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.
The chemical and physical integrity of a pharmaceutical product.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
Inflammation of the eyelids.
A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
A synthetic tetracycline derivative with similar antimicrobial activity.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A common inhabitant of the vagina and cervix and a potential human pathogen, causing infections of the male and female reproductive tracts. It has also been associated with respiratory disease and pharyngitis. (From Dorland, 28th ed)
An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.
Therapy with two or more separate preparations given for a combined effect.
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Infections by bacteria, general or unspecified.
Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.
The body region lying between the genital area and the ANUS on the surface of the trunk, and to the shallow compartment lying deep to this area that is inferior to the PELVIC DIAPHRAGM. The surface area is between the VULVA and the anus in the female, and between the SCROTUM and the anus in the male.
Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
Bites inflicted by humans.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
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  • Ofloxacin(Floxin) generic Duof is a fluoroquinolone antibiotic, prescribed for certain types of bacterial infections such as chronic bronchitis, pneumonia, skin and skin structure infections, and others. (medindia.net)
  • Ofloxacin Tablets I.P are quinolone antibiotics that are taken by mouth to treat a various bacterial infections centering skin, eye, throat, urinary tract, and breathing issues. (isconlifesciences.co.in)
  • The mechanism of action of ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.Ofloxacin has in vitro activity against a wide range of gram-negative and grampositive microorganisms. (trumachealthcare.net)
  • The Ofloxacin Tablets , we deal in, are the fluoroquinolone antibiotic that aid in treating many bacterial infections. (modernlaboratories.in)
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  • These tablets treat only bacterial infections and will not work forà  viral infections such asà  common cold,à  flu. (saintroylifescience.com)
  • Ofloxacin Tablets are used for the treatment of bacterial infections by stopping their growth. (rootslifecare.in)
  • Cefixime & Ofloxacin Tablets Are Utilized For Typhoid Fever, Urinary Tract Infections, Bacterial Infections, Ear And Eye Infections, Skin Infections, Respiratory Infections, Sexually Transmitted Infections, Etc. These Tablets May Likewise Be Utilized For Purposes Not Recorded In This Solution Guide. (medilonhealthcare.com)
  • Cefixime, Ofloxacin & Lactic Acid Bacillus Tablets- The combinations of these drugs are extensively used for treating various bacterial infection Urinary tract infections, Gastrointestinal etc. (hlhealthcare.co.in)
  • Ofloxacin is also for treating bacterial infection. (hlhealthcare.co.in)
  • Ofloxacin for eyes is helpful in treating bacterial infections of the eye including conjunctivitis also known as pink eye and ulcers of the cornea. (pillsfind.com)
  • The bactericidal effect of ofloxacin is associated with the blockade of the DNA-gyrase enzyme in bacterial cells. (pharmrus.com)
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  • Azithromycin 500 mg Tablets is used to treat a wide variety of bacterial infections. (indiamart.com)
  • Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. (wikipedia.org)
  • Ofloxacin is used in the treatment of bacterial infections such as: Acute bacterial exacerbations of COPD Community-acquired pneumonia Uncomplicated skin and skin structure infections Nongonococcal urethritis and cervicitis Epididymitis Mixed Infections of the urethra and cervix Acute pelvic inflammatory disease Uncomplicated cystitis Complicated urinary tract infections Prostatitis Acute, uncomplicated urethral and cervical gonorrhea Ofloxacin has not been shown to be effective in the treatment of syphilis. (wikipedia.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of ofloxacin tablets and other antibacterial drugs, ofloxacin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Ofloxacin Tablet works by killing the infection-causing bacteria. (salvavidaspharmaceutical.com)
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  • The tablets work by stopping the growth of bacteria. (saintroylifescience.com)
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  • Cipla Ofloxacin is used for treating mild to moderate infections caused by certain bacteria. (oddwayinternational.com)
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  • This product is AB-rated and is bioequivalent to Ortho-McNeil?s Floxin tablets. (pharmacytimes.com)
  • The usual dose of FLOXIN ® (ofloxacin tablets) Tablets is 200 mg to 400 mg orally every 12 h as described in the following dosing chart. (drugs.com)
  • Fluoroquinolones, including FLOXIN® (ofloxacin) , may exacerbate muscle weakness in persons with myasthenia gravis. (rxlist.com)
  • Avoid FLOXIN® (ofloxacin) in patients with a known history of myasthenia gravis (See WARNINGS ). (rxlist.com)
  • FLOXIN® (ofloxacin) Tablets contain the following inactive ingredients: anhydrous lactose, modified corn starch, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and may also contain synthetic yellow iron oxide. (rxlist.com)
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  • Ofloxacin Tablets are indicated for the treatment of adults with mild-to-moderate infections (unless otherwise indicated) caused by susceptible strains of designated microorganisms. (pharmacytimes.com)
  • J01MA01 - ofloxacin is from the family of fluoroquinolones and is administered for the routine therapy and systemic management of infections. (knoji.com)
  • S01AX11 - ofloxacin is from the family of other anti-infective and is administered for treating eye infections. (knoji.com)
  • Ofloxacin Tablet is a medicine that is used for the treatment of Urinary Tract Infections, Respiratory Infections, Skin Infections, Soft Tissue Infections, Sexually Transmitted Infections, Eye and Ear Infection and other conditions. (salvavidaspharmaceutical.com)
  • These tablets are demanded to treat bronchitis, pneumonia, urinary tract infections (UTIs), and gonorrhea. (glomphypcd.com)
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  • Ofloxacin is used to treat certain infections including pneumonia, and infections of the skin, bladder, reproductive organs, and prostate (a male reproductive gland). (medlineplus.gov)
  • Ofloxacin may also be used to treat bronchitis and urinary tract infections but should not be used for bronchitis and some types of urinary tract infections if other treatments are available. (medlineplus.gov)
  • Antibiotics such as ofloxacin will not work for colds, flu, or other viral infections. (medlineplus.gov)
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  • Ornof (ofloxacin) tablets Active ingredients: Each coated Ornof tabs contain ornidazole 500 mg and ofloxacin 200 mg. (knoji.com)
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  • Nitazoxanide-Ofloxacin is an antiparasitic and antibacterial medication used in the treatment of diarrhea. (internationaldrugmart.com)
  • If your physician has instructed or directed you to take Nitazoxanide-Ofloxacin medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. (internationaldrugmart.com)
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  • Ofloxacin is an antibiotic of the fluoroquinolone class. (pillsfind.com)
  • Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. (nih.gov)
  • Antacids may decrease absorption of ofloxacin (ornof tablets), do not use antacids two hour before or after using Ornof tabs. (knoji.com)
  • May decrease oral absorption of ofloxacin. (drugs.com)
  • Two simple, rapid, accurate and economical analytical methods have been developed for the simultaneous estimation of Nitazoxanide and Ofloxacin in combined tablet dosage form. (rjptonline.org)
  • Ofloxacin tablets are a synthetic broad-spectrum antimicrobial agent for oral administration. (nih.gov)
  • The following are mean peak serum concentrations in healthy 70 to 80 kg male volunteers after single oral doses of 200, 300, or 400 mg of ofloxacin or after multiple oral doses of 400 mg. (nih.gov)
  • Between 0 and 6 h following the administration of a single 200 mg oral dose of ofloxacin to 12 healthy volunteers, the average urine ofloxacin concentration was approximately 220 mcg/mL. (nih.gov)
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  • Ofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. (mayoclinic.org)
  • What other drugs could interact with Nitazoxanide-Ofloxacin? (internationaldrugmart.com)
  • Is it possible for me to take Nitazoxanide-Ofloxacin with other drugs? (internationaldrugmart.com)
  • Fluoroquinolones, including ofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. (nih.gov)
  • Ofloxacin is in a class of antibiotics called fluoroquinolones. (medlineplus.gov)
  • According to the product package insert, ofloxacin is effective against these microorganisms: Aerobic Gram-positive microorganisms: Staphylococcus aureus (methicillin-susceptible strains) Streptococcus pneumoniae (penicillin-susceptible strains) Streptococcus pyogenes Aerobic Gram-negative microorganisms Citrobacter koseri (Citrobacter diversus) Enterobacter aerogenes Escherichia coli Haemophilus influenzae Klebsiella pneumoniae Neisseria gonorrhoeae Proteus mirabilis Pseudomonas aeruginosa Other microorganisms: Chlamydia trachomatis In general, fluoroquinolones are well tolerated, with most side effects being mild to moderate. (wikipedia.org)
  • The single dose and steady-state plasma profiles of ofloxacin injection were comparable in extent of exposure (AUC) to those of ofloxacin tablets when the injectable and tablet formulations of ofloxacin were administered in equal doses (mg/mg) to the same group of subjects. (nih.gov)
  • A maximum dose of 400 mg of ofloxacin per day should therefore not be exceeded. (drugs.com)
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  • However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution and an adjustment in the dose for patients receiving ofloxacin. (mayoclinic.org)
  • This can occur after the first dose of ofloxacin. (medlineplus.gov)
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  • Ofloxacin works against a broad variety of gram-positive and gram-negative microorganisms. (knoji.com)
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