A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
Protein structural motifs that play a role in protein-protein binding. The motifs are comprised of approximately 50 residues. Their name derives from the fact that they were found in cyclin F.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
Proteins prepared by recombinant DNA technology.
Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A superfamily of proteins that share a highly conserved MADS domain sequence motif. The term MADS refers to the first four members which were MCM1 PROTEIN; AGAMOUS 1 PROTEIN; DEFICIENS PROTEIN; and SERUM RESPONSE FACTOR. Many MADS domain proteins have been found in species from all eukaryotic kingdoms. They play an important role in development, especially in plants where they have an important role in flower development.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.
Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Structured vocabularies describing concepts from the fields of biology and relationships between concepts.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The field of biology which deals with the process of the growth and differentiation of an organism.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Software application for retrieving, presenting and traversing information resources on the World Wide Web.
Specific languages used to prepare computer programs.
Organized activities related to the storage, location, search, and retrieval of information.

p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. (1/1708)

p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in development remains unknown. The fruit fly, Drosophila melanogaster, has two p38 genes, D-p38a and D-p38b. To elucidate the developmental function of the Drosophila p38's, we used various genetic and pharmacological manipulations to interfere with their functions: expression of a dominant-negative form of D-p38b, expression of antisense D-p38b RNA, reduction of the D-p38 gene dosage, and treatment with the p38 inhibitor SB203580. Expression of a dominant-negative D-p38b in the wing imaginal disc caused a decapentaplegic (dpp)-like phenotype and enhanced the phenotype of a dpp mutant. Dpp is a secretory ligand belonging to the transforming growth factor beta superfamily which triggers various morphogenetic processes through interaction with the receptor Thick veins (Tkv). Inhibition of D-p38b function also caused the suppression of the wing phenotype induced by constitutively active Tkv (TkvCA). Mosaic analysis revealed that D-p38b regulates the Tkv-dependent transcription of the optomotor-blind (omb) gene in non-Dpp-producing cells, indicating that the site of D-p38b action is downstream of Tkv. Furthermore, forced expression of TkvCA induced an increase in the phosphorylated active form(s) of D-p38(s). These results demonstrate that p38, in addition to its role as a transducer of emergency stress signaling, may function to modulate Dpp signaling.  (+info)

Ectopic expression of the transforming growth factor beta type II receptor disrupts mesoderm organisation during mouse gastrulation. (2/1708)

Transforming growth factor beta (TGFbeta) regulates the cell cycle and extracellular matrix (ECM) deposition of many cells in vitro. We have analysed chimaeric mouse embryos generated from embryonic stem cells with abnormal receptor expression to study the effect of TGFbeta on these processes in vivo and the consequences for normal development. The binding receptor for TGFbeta, TbetaRII, is first detected in the embryo proper around day 8.5 in the heart. Ectopic expression of TbetaRII from the blastocyst stage onward resulted in an embryonic lethal around 9.5 dpc. Analysis of earlier stages revealed that the primitive streak of TbetaRII chimaeras failed to elongate. Furthermore, although cells passed through the streak and initially formed mesoderm, they tended to accumulate within the streak. These defects temporally and spatially paralleled the expression of the TGFbeta type I receptor, which is first expressed in the node and primitive streak. We present evidence that classical TGFbeta-induced growth inhibition was probably the cause of insufficient mesoderm being available for paraxial and axial structures. The results demonstrate that (1) TGFbeta mRNA and protein detected previously in early postimplantation embryos is present as a biologically active ligand; and (2) assuming that ectopic expression of TbetaRII results in no other changes in ES cells, the absence of TbetaRII is the principle reason why the embryo proper is unresponsive to TGFbeta ligand until after gastrulation.  (+info)

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. (3/1708)

Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary gland and first branchial arch. Here, we report that Pitx1 gene-deleted mice exhibit striking abnormalities in morphogenesis and growth of the hindlimb, resulting in a limb that exhibits structural changes in tibia and fibula as well as patterning alterations in patella and proximal tarsus, to more closely resemble the corresponding forelimb structures. Deletion of the Pitx1 locus results in decreased distal expression of the hindlimb-specific marker, the T-box factor, Tbx4. On the basis of similar expression patterns in chick, targeted misexpression of chick Pitx1 in the developing wing bud causes the resulting limb to assume altered digit number and morphogenesis, with Tbx4 induction. We hypothesize that Pitx1 serves to critically modulate morphogenesis, growth, and potential patterning of a specific hindlimb region, serving as a component of the morphological and growth distinctions in forelimb and hindlimb identity. Pitx1 gene-deleted mice also exhibit reciprocal abnormalities of two ventral and one dorsal anterior pituitary cell types, presumably on the basis of its synergistic functions with other transcription factors, and defects in the derivatives of the first branchial arch, including cleft palate, suggesting a proliferative defect in these organs analogous to that observed in the hindlimb.  (+info)

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. (4/1708)

decapentaplegic (dpp), a Drosophila member of the TGFbeta family of secreted molecules, functions as a long-range morphogen in patterning of the embryo and the adult appendages. Dpp signals via the SMAD proteins Mad and Medea. Here we show that in the absence of brinker (brk), Mad is not required for the activation of Dpp target genes that depend on low levels of Dpp. brk encodes a novel protein with features of a transcriptional repressor. brk itself is negatively regulated by Dpp. Dpp signaling might relieve brk's repression of low-level target genes either by transcriptional repression of brk or by antagonizing a repressor function of brk at the target gene promoters.  (+info)

Expression pattern of Brachyury and Not in the sea urchin: comparative implications for the origins of mesoderm in the basal deuterostomes. (5/1708)

This work concerns the expression of two transcription factors during the development of the sea urchin Strongylocentrotus purpuratus: SpNot, the orthologue of the vertebrate Not gene, and SpBra, the orthologue of the vertebrate Brachyury gene. SpNot transcripts are detected by in situ hybridization in the vegetal plate at the mesenchyme-blastula stage. Later the gene is expressed in the secondary mesenchyme, but expression is no longer detectable after gastrulation. SpNot is upregulated during larval development, in the invaginating vestibule of the adult rudiment. Transcripts are also found in several larva-specific tissues, including the epaulets, blastocoelar cells, and pigment cells. SpBra also displays a discontinuous pattern of expression. Much like SpNot, this gene is expressed during embryogenesis in the embryonic vegetal plate and secondary mesenchyme founder cells, and expression is then extinguished. The gene is upregulated over a week later in the feeding larva, in the vestibule of the adult rudiment. In contrast to SpNot, SpBra is also expressed in the mesoderm of both left and right hydrocoels, and it is not expressed in any larva-specific tissues. We compare the spatial expression profile determined in this study with that of the orthologous Brachyury gene in an indirectly developing enteropneust hemichordate, a representative of the sister group to the echinoderms within the deuterostomes. These observations illuminate the genetic basis underlying the process of maximal indirect development in basal deuterostomes. Finally, Brachyury appears to be an excellent marker for the progeny of the set-aside cells of the sea urchin embryo.  (+info)

derriere: a TGF-beta family member required for posterior development in Xenopus. (6/1708)

TGF-beta signaling plays a key role in induction of the Xenopus mesoderm and endoderm. Using a yeast-based selection scheme, we isolated derriere, a novel TGF-beta family member that is closely related to Vg1 and that is required for normal mesodermal patterning, particularly in posterior regions of the embryo. Unlike Vg1, derriere is expressed zygotically, with RNA localized to the future endoderm and mesoderm by late blastula, and to the posterior mesoderm by mid-gastrula. The derriere expression pattern appears to be identical to the zygotic expression domain of VegT (Xombi, Brat, Antipodean), and can be activated by VegT as well as fibroblast growth factor (FGF). In turn, derriere activates expression of itself, VegT and eFGF, suggesting that a regulatory loop exists between these genes. derriere is a potent mesoderm and endoderm inducer, acting in a dose-dependent fashion. When misexpressed ventrally, derriere induces a secondary axis lacking a head, an effect that is due to dorsalization of the ventral marginal zone. When misexpressed dorsally, derriere suppresses head formation. derriere can also posteriorize neurectoderm, but appears to do so indirectly. Together, these data suggest that derriere expression is compatible only with posterior fates. In order to assess the in vivo function of derriere, we constructed a dominant interfering Derriere protein (Cm-Derriere), which preferentially blocks Derriere activity relative to that of other TGFbeta family members. Cm-derriere expression in embryos leads to posterior truncation, including defects in blastopore lip formation, gastrulation and neural tube closure. Normal expression of anterior and hindbrain markers is observed; however, paraxial mesodermal gene expression is ablated. This phenotype can be rescued by wild-type derriere and by VegT. Our findings indicate that derriere plays a crucial role in mesodermal patterning and development of posterior regions in Xenopus.  (+info)

Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis. (7/1708)

T-box genes are conserved in all animal species. We have identified two members of the T-box gene family from the zebrafish, Danio rerio. Zf-tbr1 and zf-tbx3 share high amino acid identity with human, murine, chick and Xenopus orthologs and are expressed in specific regions during zebrafish development.  (+info)

Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. (8/1708)

In spite of recent breakthroughs in understanding limb patterning, the genetic factors determining the differences between the forelimb and the hindlimb have not been understood. The genes Pitx1 and Tbx4 encode transcription factors that are expressed throughout the developing hindlimb but not forelimb buds. Misexpression of Pitx1 in the chick wing bud induced distal expression of Tbx4, as well as HoxC10 and HoxC11, which are normally restricted to hindlimb expression domains. Wing buds in which Pitx1 was misexpressed developed into limbs with some morphological characteristics of hindlimbs: the flexure was altered to that normally observed in legs, the digits were more toe-like in their relative size and shape, and the muscle pattern was transformed to that of a leg.  (+info)

TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been shown to contribute directly to tumour formation, migration and invasion. However, little is known about the molecular basis for its role in development and oncogenesis because there is a paucity of information regarding its target genes. The cyclin-dependent kinase inhibitor p21WAF1 plays a pivotal role in a myriad of processes including cell cycle arrest, senescence and apoptosis and here we provide a detailed mechanism to show that it is a direct and biologically relevant target of TBX3. Using a combination of luciferase reporter gene assays and in vitro and in vivo binding assays we show that TBX3 directly represses the p21WAF1 promoter by binding a T-element close to its initiator. Furthermore, we show that the TBX3 DNA binding domain is required for the transcriptional repression of p21WAF1
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been shown to contribute directly to tumour formation, migration and invasion. However, little is known about the molecular basis for its role in development and oncogenesis because there is a paucity of information regarding its target genes. The cyclin-dependent kinase inhibitor p21WAF1 plays a pivotal role in a myriad of processes including cell cycle arrest, senescence and apoptosis and here we provide a detailed mechanism to show that it is a direct and biologically relevant target of TBX3. Using a combination of luciferase reporter gene assays and in vitro and in vivo binding assays we show that TBX3 directly represses the p21WAF1 promoter by binding a T-element close to its initiator. Furthermore, we show that the TBX3 DNA binding domain is required for the transcriptional repression of p21WAF1
TBS 19, TBX19, FLJ26302, TPIT, dJ747L4.1, T-box protein 19, TBS19, T-box transcription factor TBX19, T-box factor, pituitary, FLJ34543, dj747L4.1, T-box 19 ...
Mutations in the human T-box transcription factor gene TBX3 underlie the autosomal dominant disorder known as ulnar-mammary syndrome (UMS; OMIM 181450) (Bamshad et al., 1997). Human TBX3 was identified during an attempt to positionally clone the gene responsible for another developmental disorder, Holt-Oram syndrome, which had been mapped to chromosome 12q. Although it was later found that Holt-Oram syndrome is caused by mutations in the closely linked human TBX5 gene (Basson et al., 1997; Li et al., 1997), mutations in TBX3 were identified in individuals with ulnar-mammary syndrome, a developmental disorder that was also mapped to this chromosomal region (Bamshad et al., 1995; Bamshad et al., 1997). A number of different mutations in TBX3 have been identified in families with ulnar-mammary syndrome, most of which are predicted to encode truncated proteins or missense mutations resulting in loss of function (Coll et al., 2002) (for a review, see Papaioannou, 2001). UMS is fully penetrant but ...
Consistent with the finding that Fas deficiency might also alter homeostasis of conventional immune cell lineages independently of Eomes, we found that the autoimmune manifestations of ALPS were not affected by the T cell-specific deletion of Eomes (Fig. 2E, 2F). This result was not unexpected because independent lines of evidence have uncoupled DN T cell accumulation from the pathogenic autoantibody production of ALPS (3, 4, 9). Whereas B cell- or DC-specific deficiency of Fas is not sufficient to drive DN T cell expansion, either is sufficient to recapitulate the autoantibody production of ALPS (3, 4). CD4+ T cells, DCs, and B cells are still present and Fas-deficient in lpr/lpr, Eomes F/F, Cd4:Cre+ mice, providing a sufficient cellular network for the elaboration of pathogenic autoantibodies. Taken together, these data suggest that the Eomes-dependent DN T cell population is responsible for the lymphoproliferative phenotype but does not appear to be required for the humoral autoimmunity ...
Previous work has demonstrated that two key melanocyte-specific elements termed the MSEu and MSEi play critical roles in the expression of the melanocyte-specific tyrosinase-related protein 1 (TRP-1) promoter. Both the MSEu and MSEi, located at position -237 and at the initiator, respectively, bind a melanocyte-specific factor termed MSF but are also recognized by a previously uncharacterized repressor, since mutations affecting either of these elements result in strong up-regulation of TRP-1 promoter activity in melanoma cells. Here we demonstrate that repression mediated by the MSEu and MSEi also operates in melanocytes. We also report that both the MSEu and MSEi are recognized by the brachyury-related transcription factor Tbx2, a member of the recently described T-box family, and that Tbx2 is expressed in melanocyte and melanoblast cell lines but not in melanoblast precursor cells. Although Tbx2 and MSF each recognize the TRP-1 MSEu and MSEi motifs, it is binding by Tbx-2, not binding by MSF, that
T-box transcription factor TBX22 is a protein that in humans is encoded by the TBX22 gene. TBX22 is a member of a phylogenetically conserved family of proteins that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, cleft palate with ankyloglossia (tongue-tie), and it is believed to play a major role in human palatogenesis. It has previously been mapped to the long arm of the X chromosome and it has now been demonstrated that mutations in the gene TBX22 are the cause of this syndrome. TBX22 mutations also result in non-syndromic cleft palate in some populations. TBX22 is composed of seven exons spanning 8.7 kilobases of genomic DNA in Xq21.1. The TBX22 mRNA is 2099 base pairs long and encodes a 400-amino-acids protein containing a T-domain in its NH2-terminal region which has the unique feature of missing 20 amino-acids ...
TY - JOUR. T1 - Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. AU - Chapman, Deborah L.. AU - Garvey, Nancy. AU - Hancock, Sarah. AU - Alexiou, Maria. AU - Agulnik, Sergei I.. AU - Gibson-Brown, Jeremy J.. AU - Cebra-Thomas, Judith. AU - Bollag, Roni Jacob. AU - Silver, Lee M.. AU - Papaioannou, Virginia E.. PY - 1996/8/1. Y1 - 1996/8/1. N2 - A novel family of genes, characterized by the presence of a region of homology to the DNA-binding domain of the Brachyury (T) locus product, has recently been identified. The region of homology has been named the T-box, and the new mouse genes that contain the T-box domain have been named T-box 1-6 (Tbx1 through Tbx6). As the basis for further study of the function and evolution of these genes, we have examined the expression of 5 of these genes, Tbx1-Tbx5, across a wide range of embryonic stages from blastocyst through gastrulation and early organogenesis by in situ hybridization of wholemounts and tissue sections. Tbx3 is ...
EOMES expression is increased in D*V embryonic comb tissue.Results of qRT-PCR analysis demonstrating increased EOMES expression in D*V embryonic comb tissue whe
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
J:96466 Singh MK, Petry M, Haenig B, Lescher B, Leitges M, Kispert A, The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev. 2005 Feb;122(2):131-44 ...
TY - JOUR. T1 - Specification and determination of limb identity. T2 - Evidence for inhibitory regulation of Tbx gene expression. AU - Saito, Daisuke. AU - Yonei-Tamura, Sayuri. AU - Kano, Kohko. AU - Ide, Hiroyuki. AU - Tamura, Koji. PY - 2002/8/20. Y1 - 2002/8/20. N2 - Limb-type-specific expression of Tbx5/Tbx4 plays a key role in drawing distinction between a forelimb and a hindlimb. Here, we show insights into specification and determination during commitment of limb-type identity, in particular that median tissues regulate Tbx expressions. By using the RT-PCR technique on chick embryos, the onset of specific Tbx5/Tbx4 expression in the wing/leg region was estimated to be stage 13. Specification of the limb-type identity is thought to occur before stage 9, since all explants from stage 9 through 14 expressed the intrinsic Tbx gene autonomously in a simple culture medium. The results of transplantation experiments revealed that axial structures medial to the lateral plate mesoderm at the ...
Read Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
TY - JOUR. T1 - TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines. AU - Fan, Weiwei. AU - Huang, Xu. AU - Chen, Chira. AU - Gray, Joe. AU - Huang, Taosheng. PY - 2004/8/1. Y1 - 2004/8/1. N2 - TBX3 is a transcription factor of the T-box gene family. Mutations of TBX3 cause ulnar-mammary syndrome (MIM 181450) in humans, an autosomal dominant disorder characterized by the absence or underdevelopment of the mammary glands and other congenital anomalies. It recently was found that TBX3 was able to immortalize mouse embryo fibroblast (MEF) cells. In addition, TBX2, a homologue of TBX3, is active in preventing senescence in rodent cells and was found to be amplified in some human breast cancers, suggesting TBX3 plays a role in breast cancer. This study examined the function of TBX3 and its isoform, TBX3 + 2a. TBX3 + 2a differs from TBX3 in the DNA binding domain with an extra 20 amino acids produced by ...
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008 ...
A detailed understanding of the immune response to human immunodeficiency virus (HIV) infection is needed to inform prevention and therapeutic strategies that aim to contain the AIDS pandemic. The CD8+ T cell response plays a critical role in controlling viral replication during HIV infection and will likely need to be a part of any vaccine approach. The qualitative feature of the CD8+ T cell response most closely associated with immunologic control of HIV infection is its cytotoxic capacity. The pore-forming protein, perforin, is a major determinant of the cytotoxic capacity of CD8+ T cells. In the context of chronic HIV infection, enhanced perforin expression by HIV-specific CD8+ T cells is associated with greater control over HIV replication. However, individuals experiencing chronic progressive infection (CP) often demonstrate a diminished ability to express this important cytolytic molecule. HIV-specific CD8+ T cells from CP also express lower levels of the T-box transcription factor T-bet, an
Transcription factors of the T-box family are required both for early cell-fate decisions, such as those necessary for formation of the basic vertebrate body plan, and for differentiation and organogenesis [ (PUBMED:12093383) ]. The T-box is defined as the minimal region within the T-box protein that is both necessary and sufficient for sequence-specific DNA binding, all members of the family so far examined bind to the DNA consensus sequence TCACACCT. The T-box is a relatively large DNA-binding domain, generally comprising about a third of the entire protein (17-26kDa) [ (PUBMED:9349824) ]. These genes were uncovered on the basis of similarity to the DNA binding domain [ (PUBMED:9504043) ] of Mus musculus (Mouse) Brachyury (T) gene product, which similarity is the defining feature of the family. The Brachyury gene is named for its phenotype, which was identified 70 years ago as a mutant mouse strain with a short blunted tail. The gene, and its paralogues, have become a well-studied model for ...
GATA-4 is a key regulator of a poorly understood cardiac morphogenetic program. We used genomic regions of the GATA-4 gene to target GFP expression to the devel
T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than transcriptional activators, and are closely related in terms of development and tumorigenesis. This gene plays a significant role in embryonic and fetal development through control of gene expression, and also has implications in various cancers. Tbx2 is associated with numerous signaling pathways, BMP, TGFβ, Wnt, and FGF, which allow for patterning and proliferation during organogenesis in fetal development. During fetal development, the relationship of Tbx2 to FGF, BMP, and Wnt signaling pathways indicates its extensive control in development of various organ systems. It functions predominantly in the patterning of organ development rather than ...
The T-box transcription factors are a family of developmentally regulated DNA-binding proteins that play important roles in organogenesis (Papaioannou, 2001). Their function is conserved throughout evolution, and they participate in developmental processes such as cell lineage choices, terminal differentiation and proliferation. Notable in both mice and humans is the marked dependency on T-box transcription factor dose, which is evident in the case of dominant human or mouse mutations that lead to several inherited syndromes affecting the heart and other organs (Basson et al., 1997; Bruneau et al., 2001; Li et al., 1997; Lindsay et al., 2001; Merscher et al., 2001; Packham and Brook, 2003; Yagi et al., 2003).. In the heart, T-box genes play important roles in the development of specific cardiac structures and in the transcription of specific cardiac genes. Tbx5 specifies the formation of the posterior segments of the heart, the atria and left ventricle; decreased Tbx5 dose results in defective ...
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors. ...
Buy our Human Tbx20 peptide. Ab99540 is a blocking peptide for ab42468 and has been validated in BL. Abcam provides free protocols, tips and expert support for…
Progressive lung fibrosis, particularly the idiopathic form, causes severe pulmonary dysfunction with limited treatment options. While it is known that a combination of epithelial injury, accumulation of activated fibroblasts, and deposition of cellular matrix contribute to this disease, the underlying molecular mechanisms and cellular components remain incompletely characterized. In particular, fibroblast accumulation plays a central role in tissue fibrosis, but the regulation and cellular origins of this facet of disease are unclear. Ting Xie and colleagues of Cedars-Sinai Medical Center have discovered that the embryonic transcription factor TBX4 contributes to lung fibrosis by facilitating fibroblast accumulation. Using in vivo lineage tracing, cell surface marker analysis, and gene expression profiling, the group demonstrated that TBX4-expressing progenitors give rise to a variety of lung cell types, and importantly, are a major source of activated fibroblasts. In a mouse model, ...
The mouse Brachyury (T) gene is the prototype of a growing family of so-called T-box genes which encode transcriptional regulators and have been identified in a variety of invertebrates and vertebrates, including humans. Mutations in Brachyury and other T-box genes result in drastic embryonic phenotypes, indicating that T-box gene products are essential in tissue specification, morphogenesis and organogenesis. The T-box encodes a DNA-binding domain of about 180 amino-acid residues, the T domain. Here we report the X-ray structure of the T domain from Xenopus laevis in complex with a 24-nucleotide palindromic DNA duplex. We show that the protein is bound as a dimer, interacting with the major and the minor grooves of the DNA. A new type of specific DNA contact is seen, in which a carboxy-terminal helix is deeply embedded into an enlarged minor groove without bending the DNA. Hydrophobic interactions and an unusual main-chain carbonyl contact to a guanine account for sequence-specific recognition ...
Abstract B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a...
The importance of the BCR and TLR9 in autoimmunity and in the production of autoantibodies is well established but the underlying molecular mechanism still needs to be determined. Here we aim to characterize the BCR-TLR9 crosstalk by its effect on T-bet, as T-bet is activated and regulated by both receptors and has an important role in class-switching to pathological IgG2a in mice. Using primary mouse B cells, we demonstrate that T-bet expression is synergistically elevated by the crosstalk between the BCR and TLR9. To test the effect of this synergy on IgG2a-switching, the levels of switched B cells were checked by functional tests. We found that BCR co-stimulation had no additional effect on TLR9-induced IgG2a expression however the expression of Rad51 was synergistically increased. To check the biological significance of the synergy we compared T-bet expression in B cells from healthy and CIA (collagen-induced arthritis) mice but no differences were found. Taken together, we demonstrate here ...
Complete information for TBX21 gene (Protein Coding), T-Box Transcription Factor 21, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-spectrometry proteomic analysis-multiple reaction monitoring mass spectrometry. We used this method to detect and quantify predicted phosphopeptides derived from T-bet. By analyzing activated murine wild-type and Rheb-deficient CD4+ T cells, as well as murine CD4+ T cells activated in the presence of rapamycin, a pharmacologic inhibitor of mTORC1, we were able to identify six T-bet phosphorylation sites. Five of these are novel, and four sites are consistently dephosphorylated in both Rheb-deficient CD4+ T cells and T cells treated with rapamycin, suggesting mTORC1 signaling controls their phosphorylation. Alanine mutagenesis of each of the six phosphorylation sites was ...
Mouse polyclonal antibody raised against a full-length human TBX18 protein. TBX18 (ADR83216.1, 1 a.a. ~ 607 a.a) full-length human protein. (H00009096-B01P) - Products - Abnova
Human TBX3 partial ORF ( NP_005987, 311 a.a. - 410 a.a.) recombinant protein with GST-tag at N-terminal. (H00006926-Q01) - Products - Abnova
EOMES, clone: WD1928, eBioscience™ 25μg; Unconjugated EOMES, clone: WD1928, eBioscience™ Primary Antibodies Eo to Ep
Complete information for TBX3 gene (Protein Coding), T-Box 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Given the complexity of Notch receptor and ligand expression during development of the epicardium and the coronary system, we assumed that redundancy between receptors and ligands, respectively, may necessitate the simultaneous removal of 2 or more genes to assign a Notch signaling requirement to these processes. We therefore decided to analyze the phenotypic consequences of removal of Rbpj that encodes a unique intracellular mediator of (canonical) Notch signaling.14 Because Rbpj-deficiency results in early embryonic lethality in mice,15 we used a tissue-specific inactivation approach using a Tbx18cre line generated in our laboratory and a floxed Rbpj allele to analyze Notch signaling function in the PEO and epicardium.10,12 The T-box transcription factor gene Tbx18 is strongly expressed in the PEO at E9.5, and in the epicardium until E16.5. Other cardiac expression domains include the sinus horn mesenchyme/myocardium, and the myocardium of the left ventricle and the interventricular septum ...
The undifferentiated stem cells of the embryo develop either into cells of the nervous system, the so-called neuroectoderm, or into cells of the meso- and endoderm, from which, for example, many different cell types of the internal organs or the muscles develop. For over 25 years it has been known that this decision is regulated by embryonic signaling molecules, such as TGFβ and Wnt signals. So far, however, it has remained unclear exactly how these signals control this first decision of cell differentiation. The study, carried out in the context of Tosics doctoral thesis, shows that the embryonic TGFβ and Wnt signals are transmitted by gene-regulating transcription factors of the T-box factor family, namely Eomes and Brachyury. These factors are responsible for turning on the differentiation gene programs for all meso- and endoderm cells. At the same time, these T-box factors also act as gene repressors, preventing the formation of neural tissue by suppressing the corresponding gene ...
Mutation analysis of our cohort of non-deleted patients did not detect any cases with unambiguous loss of TBX1 function. Considering the strong experimental evidence for a major role of TBX1 in the 22q11 deletion syndrome from the deletion studies in the mouse,14-16 our findings are somewhat surprising. In contrast to our results, the majority of mutations inTBX5 in association with Holt-Oram syndrome are predicted to produce haploinsufficiency by nonsense or frameshift mutations within the T box region.12 13 23 Similarly, five of the 10 published mutations in TBX3, found in patients with ulnar-mammary syndrome, are predicted to disrupt the DNA binding domain.24 It is likely that the aetiology of non-deleted DGS/VCFS patients is heterogeneous. Malformations similar to those seen in the 22q11 deletion syndrome have been associated with prenatal exposure to retinoic acids and ethanol, maternal diabetes, and deletions of the short arm of chromosome 10. Therefore, it is possible that mutations ...
In recent years, numerous groups provided compelling evidence for the existence of somatic stem cells in the heart of different mammalian species. Stem cells and progenitor cells are supposed to exist in niches, where they remain in an undifferentiated and quasi-dormant state until external signals stimulate commitment and differentiation to specific somatic cells which may contribute to the repair or maintenance of homeostasis of an organ. Mimicking a stem cell niche of the heart in vitro, we succeeded in the isolation of somatic stem cells from postnatal murine hearts and could maintain these cells as monoclonal self-renewing cells lines expressing Oct4, Sox2 and Nanog for several years (Fig. 1). These cells obviously committed to the mesodermal lineage and expressing early myocardial transcription factors Brachyury, Nkx2.5, GATA4, and Isl1 exclusively differentiate to cardiomyocytes, smooth muscle cells, and vascular endothelial cells and thus were named cardiovascular progenitor cells ...
Abstract. Atrial fibrillation (AF), the most common type of cardiac rhythm disturbance encountered in clinical practice, is associated with substantially increased morbidity and mortality. Aggregating evidence demonstrates that abnormal cardiovascular development is involved in the pathogenesis of AF. A recent study has revealed that the TBX5 gene, which encodes a T-box transcription factor key to cardiovascular development, was associated with AF and atypical Holt-Oram syndrome. However, the prevalence and spectrum of TBX5 mutation in patients with lone AF remain unclear. In this study, the coding regions and splicing junction sites of TBX5 were sequenced in 192 unrelated patients with lone AF and 300 unrelated ethnically-matched healthy individuals used as controls. The causative potential of the identified TBX5 variation was evaluated by MutationTaster and PolyPhen-2. The functional effect of the mutant TBX5 was assayed by using a dual-luciferase reporter assay system. As a result, a novel ...
Several genes containing the conserved T-box region in invertebrates and vertebrates have been reported recently. Here, we describe three novel members of the T-box gene family in zebrafish. One of these genes, tbx-c, is studied in detail. It is expressed in the axial mesoderm, notably, in the notochordal precursor cells immediately before formation of the notochord and in the chordoneural hinge of the tail bud, after the notochord is formed. In addition, its expression is detected in the ventral forebrain, sensory neurons, fin buds and excretory system. The expression pattern of tbx-c differs from that of the other two related genes, tbx-a and tbx-b. The developmental role of tbx-c has been analysed by overexpression of the full-length tbx-c mRNA and a truncated form of tbx-c mRNA, which encodes the dominant-negative Tbx-c. Overexpression of tbx-c causes expansion of the midline mesoderm and formation of ectopic midline structures at the expense of lateral mesodermal cells. In dominant-negative ...
TY - JOUR. T1 - Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells. AU - Gruarin, Paola. AU - Maglie, Stefano. AU - De Simone, Marco. AU - Häringer, Barbara. AU - Vasco, Chiara. AU - Ranzani, Valeria. AU - Bosotti, Roberto. AU - Noddings, Johanna S. AU - Larghi, Paola. AU - Facciotti, Federica. AU - Sarnicola, Maria L. AU - Martinovic, Martina. AU - Crosti, Mariacristina. AU - Moro, Monica. AU - Rossi, Riccardo L. AU - Bernardo, Maria E. AU - Caprioli, Flavio. AU - Locatelli, Franco. AU - Rossetti, Grazisa. AU - Abrignani, Sergio. AU - Pagani, Massimiliano. AU - Geginat, Jens. N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.. PY - 2018/11/15. Y1 - 2018/11/15. N2 - Whether human IL-10-producing regulatory T cells (Tr1) represent a distinct differentiation lineage or an unstable activation stage remains a key unsolved issue. Here, we report that Eomesodermin (Eomes) acted as a lineage-defining transcription factor in human ...
It has been shown that IFN-γ is required for tumor immune surveillance as mice impaired in the secretion of this cytokine are prone to develop spontaneous tumors (25). More recently, it was observed that an IFN-γ-dependent signature and a Th1 immune environment are associated with better prognosis in cancer (10, 12, 13, 23, 26, 27). For instance, good prognosis of ovarian cancer is associated with enhanced Th1 infiltrates and expression of IFN-γ, IL-2, and HLA-class I molecules (27, 28). Similarly, a coordinated cytotoxic Th1 immune phenotype expressing the transcription factor T-box protein 21 (T-bet), interferon regulatory factor 1 (IRF-1), and IFN-γ is associated with good prognosis in colorectal cancer (10, 23). A similar phenomenon was recently reported by our group in breast cancer (13). Interestingly, similar signatures associated with activated IFN-γ signaling are predictive of immune responsiveness to vaccine therapy. Gajewski and colleagues (8, 29) observed that pretreatment ...
T-box anti-termination is an elegant and sensitive mechanism by which many bacteria maintain constant levels of amino acid-charged tRNAs. The amino acid specificity of the regulatory element is related to a so-called specifier codon and can in principle be used to guide the functional annotation of the genes controlled via the T-box anti-termination mechanism. Hidden Markov Models were defined to search the T-box regulatory element and were applied to all completed prokaryotic genomes. The vast majority of the genes found downstream of the retrieved elements encoded functionalities related to transport and synthesis of amino acids and the charging of tRNA. This is completely in line with findings reported in literature and with the proposed biological role of the regulatory element. For several species, the functional annotation of a large number of genes encoding proteins involved in amino acid transport could be improved significantly on basis of the amino acid specificity of the identified T-boxes.
TBX5 Full-Length MS Protein Standard (NP_000183), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
T-bet is a Type-1 transcription factor that regulates the development of Type-1 T cell and Type-1 anti-tumor immunity. T-bet expression in Dendritic Cells (DC) is required for the ability of these antigen-presenting cells (APC) to prime Type-1-polarized T cell responses. Since T-bet is typically expressed by very low frequencies of activated DC (, 1%), we hypothesized that ectopic expression of T-bet as a consequence of recombinant adenovirus (rAd).T-bet transfection would yield a robust population of DC that were capable of (re)polarizing Type-1 anti-tumor T cell responses in vitro and in vivo. Indeed, human DC engineered to express high levels of T-bet strongly potentiated the development of Type-1 T cells from naïve T cells and concomitantly suppressed Th2 and Regulatory T cell (Treg) development in vitro. Interestingly, the superior Type-1 functionality of DC.Tbet seems to be largely independent of intrinsic Interleukin-12 (IL-12) production, as IL-12 neutralizing antibody failed to affect ...
All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain. The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures. We are interested in understanding how signalling centres are established in the embryo and how signalling pathways are regulated during development. Current research projects in the lab primarily focus on the fibroblast growth factor (FGF) signalling pathway and our aim is to elucidate how deregulated FGF signalling results in birth defects and cellular malfunction. We are particulalrly interested in understanding the functions of the Sprouty genes, which encode FGF antagonists, Tbx1, a T-box transcription factor implicated in DiGeorge syndrome and Chd7, a chromatin remodeller, mutated in CHARGE syndrome. We are studying the role of these genes in the development of the ...
MSGN1 Full-Length MS Protein Standard (NP_001099039), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation.
Author summary A molecular understanding of cardiomyocyte development is an essential goal for improving clinical approaches to CHD. While TBX20 is an essential transcription factor for heart development and its disease relevance is well established, many fundamental questions remain about the mechanism of TBX20 function. Principle among these is how TBX20 mutations associated with adult dilated cardiomyopathy circumvent (DCM) the essential embryonic requirement for TBX20 in heart development. Here we report using an integrated approach that TBX20 complexes with the cardiac transcription factor CASZ1 in vivo. We confirmed TBX20 and CASZ1 interact biochemically and genetically, and show mice heterozygous for both Tbx20 and Casz1 die, beginning at 4 to 8 weeks post birth, exhibiting hallmarks of DCM. Interestingly, the human mutant TBX20F256I bypasses the early essential requirement for TBX20 but leads to DCM. We report here that TBX20F256I disrupts the TBX20-CASZ1 interaction, ascribing clinical
B-1 cells and IgM NAbs. In mice, B-1a cells are more properly regarded as an arc of innate immunity. They respond to T cell-independent antigens by secretion of IgM and IgA NAbs, whose repertoire results from natural selection. Importantly, OSEs such as those found on oxLDL and apoptotic cells are a major target of NAbs in both mice and humans (reviewed in ref. 7). Considerable evidence supports an atheroprotective role for IgM specific for OSEs in mice. Immunization of mice with heat-killed S. pneumoniae, which shares molecular identity with oxidized phospholipids of oxLDL, leads to marked increases in IgM specific for oxLDL, which blocks oxLDL uptake by macrophages and inhibits atherosclerosis (79). T-bet deficiency and CD74 deficiency, both associated with reduced atherosclerosis, result in marked increases in IgM NAbs specific for oxLDL (33, 80). Ldlr-/- mice deficient in the ability to secrete IgM (sIgM-/- mice) have dramatically increased atherosclerosis (81). Splenectomy was shown to ...
T-bet Mouse anti-Human, Mouse, PerCP-Cy5.5, Clone: 4B10, eBioscience™ 100μg; PerCP-Cy5.5 T-bet Mouse anti-Human, Mouse, PerCP-Cy5.5, Clone: 4B10,...
This gene is a member of a phylogenetically conserved family of genes that share a common D-binding domain, the T-box. T-box genes encode…
These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...
Suppression of cell proliferation by T-bet. Stable T-bet expressing cell clones were established in EcR-HEK cells and maintained in DMEM containing G418 and Zeo
J:63993 Carson CT, Kinzler ER, Parr BA, Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development. Mech Dev. 2000 Aug;96(1):137-40 ...
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Anti-TBR2 / Eomes antibody - ChIP Grade (ab23345) has been cited in 183 publications. References for Human, Mouse, Rat, Frt, Mmst in ChIP, ChIP/Chip, ICC…
SNORD71: encoding protein Small nucleolar RNA, C/D box 71. *SPSB3: encoding protein SplA/ryanodine receptor domain and SOCS box ... CCDC113: encoding protein Coiled-coil domain-containing protein 113. *Ccdc78: encoding protein Coiled-coil domain-containing 78 ... encoding protein CKLF-like MARVEL transmembrane domain-containing protein 2. *CCDC135: encoding protein Coiled-coil domain- ... SHCBP1: encoding protein SHC SH2 domain-binding protein 1. *SLZ1: encoding protein SLX1 structure-specific endonuclease subunit ...
DBNDD2: Dysbindin domain-containing protein 2. *DDX27: DEAD box polypeptide 27. *DEFB118, DEFB119, DEFB126, DEFB127, DEFB129: ... YTHDF1: encoding protein YTH domain family, member 1. *ZFP64 encoding protein Zinc finger protein 64 homolog, isoforms 1 and 2 ... FASTKD5: encoding protein FAST kinase domain-containing protein 5 (FASTKD5). *FITM2: encoding protein Fat storage-inducing ... encoding protein Transmembrane prostate androgen-induced protein. *TTPAL: encoding protein Tocopherol (alpha) transfer protein- ...
The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. ... The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), ... The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and ... F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene. This gene encodes a member of ...
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain. An F-box (FBX) domain ... Members of the FBX protein family are involved in protein-protein interactions. The encoded protein may be involved in protein- ... LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene. ... Members of the LIM protein family carry the LIM domain, a unique cysteine-rich zinc-binding domain. ...
B domain. KRAB_A has a shorter α-Helix followed by a longer α-Helix. The KRAB_A motif in a zinc finger protein is known to bind ... Krüppel associated box) near the N-terminus and Zn-finger (Zinc finger) at the C-terminus of the translated protein. The former ... Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene on chromosome 6. It ... "Consensus CDS: zinc finger protein 184". Iuchi, Shiro; Kuldell, Natalie, eds. (2005). Zinc Finger Proteins: From Atomic Contact ...
Slack FJ, Ruvkun G (December 1998). "A novel repeat domain that is often associated with RING finger and B-box motifs". Trends ... The NHL repeat has also been used to design a family of fully symmetrical 6-blade beta-propeller proteins called "Pizza". These ... In many it occurs in tandem arrays, for example in the RING finger beta-box, coiled-coil (RBCC) eukaryotic growth regulators. ... The NHL repeats are also found in serine/threonine protein kinase (STPK) in diverse range of pathogenic bacteria. These STPK ...
... F-box protein 5". Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, et al. (January 2019). "The F-Box Domain- ... F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene. This gene encodes a member of the F-box protein ... The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box ... The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs ...
F-box and WD repeat domain containing 11) gene. This gene encodes a member of the F-box protein family which is characterized ... The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein ... The protein encoded by FBXW11 belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 ... F-box proteins are divided into 3 classes: Fbxws containing WD40 repeats, Fbxls containing leucine-rich repeats, and Fbxos ...
... proteins contain both MADS-box and Mef2 DNA-binding domains. Mef2 was originally identified as a transcription factor ... The MADS-box serves as the minimal DNA-binding domain, however an adjacent 29-amino acid extension called the Mef2 domain is ... similarity throughout the highly conserved N-terminal MADS-box and Mef2 domains, however their sequences diverge in their C- ... protein,+Drosophila at the US National Library of Medicine Medical Subject Headings (MeSH) Mef2+protein,+zebrafish at the US ...
High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in ... "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of ... HMG-1 belongs to the high mobility group and contains a HMG-box domain. Like the histones, HMGB1 is among the most important ... Fossati S, Chiarugi A (2007). "Relevance of high-mobility group protein box 1 to neurodegeneration". International Review of ...
At the C-terminal, senataxin has a DEAD box helicase domain. Although senataxin is widely expressed in many tissues in the body ... This gene encodes a protein named senataxin, a 302kDa protein There is high homology between human SETX and yeast Sen1. Sen1 in ... SETX encodes the senataxin protein that has a N-terminal that is likely to be involved with interacting with other proteins. ... The senataxin protein, which has RNA-DNA helicase activity, and DHX9 human helicase can resolve R-loops. This allows XRN2, an ...
... and they interact with ubiquitination targets through other protein interaction domains. F-box protein FBXO31 directs ... and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, ... F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene. Members of the F-box protein family, such as ... the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various ...
... domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B ... domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single- ... U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs ... Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions ...
Forkhead box S1 is a protein that in humans is encoded by the FOXS1 gene. The forkhead family of transcription factors belongs ... The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The ... "Entrez Gene: Forkhead box S1". Retrieved 2018-01-07. CS1 maint: discouraged parameter (link) v t e This article incorporates ... function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]. GRCh38: Ensembl release 89: ENSG00000179772 - ...
The coverage exhibited residues of the conserved polo-box domain and the two DUF domains. The protein was predominantly soluble ... The protein is also predicted to have a polo-box domain (PBD) of polo-like kinase 4 (plk4), which has predicted conservation in ... The Phyre2 server provided a predicted human protein structure that indicated domains of plk polo-box of the serine/threonine- ... Also, the polo-box domain of plk4 was found to be conserved in the C-terminus in a multiple sequence alignment in both strict ...
F-box proteins contain an F-box, which binds the rest of the SCF complex, and a substrate binding domain, which gives the E3 ... and an F-box protein, which varies. Around 70 human F-box proteins have been identified. ... mammalian F-box proteins of E3 ligases SCFFbs1and SCFFbs2. These recognition domains have small hydrophobic pockets allowing ... domain binds the E2 conjugase and might be found to mediate enzymatic activity in the E2-E3 complex An F-box domain (as in the ...
... and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact ... "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10". Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification ... F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the F-box protein ... 2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573-80. doi:10.1101/gad.1255304 ...
... and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact ... with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM] GRCh38: Ensembl ... F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene. Members of the F-box protein family, such as ... "Entrez Gene: FBXO28 F-box protein 28". Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific ...
The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs ... The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), ... F-box and leucine-rich repeat protein 4 is a protein that in humans is encoded by the FBXL4 gene. This gene encodes a member of ... The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine- ...
These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif. They dimerize with other HLH ... Barndt R, Zhuang Y (1999). "Controlling lymphopoiesis with a combinatorial E-protein code". Cold Spring Harb Symp Quant Biol. ... containing proteins through an HLH-HLH interaction. There are typically four vertebrate MRF paralogues which are homologous to ...
Certain stress-associated proteins (SAP) contain AN1 domain, often in combination with A20 zinc finger domains (SAP8) or C2H2 ... The architectural syntax is remarkably similar to that of the prokaryotic B-box zinc finger and LIM domains. Linnen JM, Bailey ... The AN1 zinc finger domain is also found in proteins containing a ubiquitin-like domain, which are involved in the ... Proteins containing an AN1-type zinc finger include: Ascidian posterior end mark 6 (pem-6) protein . Human AWP1 protein ( ...
ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the ... PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM] SPIB has been shown to interact with MAPK3 and MAPK8. GRCh38: Ensembl ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ... Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene. SPI1 (MIM 165170) and SPIB are members of a ...
The B domain contains the DUE. Lastly, the C domain is necessary for facilitating protein-protein interactions. ARSs are found ... In bacteria, the protein DnaA is the replication initiator. It gets loaded onto oriC at a DnaA box sequence where binds and ... DnaA is highly conserved and has two DNA binding domains. Just upstream to this DnaA box, is three tandem 13-mer sequences. ... These ARSs are composed of three domains A, B, and C. The A domain is where the ARS consensu s sequence resides, coined an ACS ...
The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has ... Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene. This gene encodes a member of the ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. v t e. ... Liu XL, Lei XB, Wang JW, Hong T (February 2011). "[Identification A novel protein TRIM38 that activate NF-kappaB signaling ...
... the HNPP-box. Another class of variants has high mobility group 1 (HMG1) protein sequence as a domain. Both major classes of ... In addition Sp100 interacts with a chromatin binding protein, HP1 alpha. Some Sp100 variants contain a domain similar to two ... Two other proteins, PIC1/SUMO-1, that also interact with nuclear pore complex factors also interact with these two proteins. ... Two proteins, Sp100 and promyelocytic leukemia (PML) factor are localized to punctate domains in the nucleus (nuclear dots or ...
identified asymmetric E-boxes bound by a subset of bHLH proteins with PAS domains (bHLH-PAS proteins), including Single-minded ... bHLH proteins typically bind to a consensus sequence called an E-box, CANNTG. The canonical E-box is CACGTG (palindromic), ... showed that dimers of various bHLH proteins bind to a short DNA motif (later called E-Box). This E-box consists of the DNA ... These proteins contain two additional PAS domains after the bHLH domain. AhR BMAL-1-CLOCK HIF NPAS1, NPAS3, MOP5 EMC HEY1 and ...
The KH domain is a conserved motif which characterizes many RNA-binding proteins. Mutagenesis of this domain resulted in ... The RNA-binding abilities of FMRP are dependent upon its KH domains and RGG boxes. ... is a human gene that codes for a protein called fragile X mental retardation protein, or FMRP. This protein, most commonly ... "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits ...
MADS-box genes encode for MADS-domain proteins, which are generally transcription factors. In plants, these proteins control ... The 28 proteins, encoded by the E. pusilla MADS-box genes, are classified as type I or type II based on BLASTP analyses. ... Due to their role in plant growth, the characterization of MADS-box genes in E. pusilla has turned into a hot topic for both ... To date, 28 MADS-box genes were isolated in E. pusilla, namely EpMADS1 to 28. Nearly all of them contain introns greater than ...
The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains: RING B-box type 1 zinc ... The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β ... TRIM33+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197-205 ...
The protein attaches to the DNA of other proteins and controls their activity through the forkhead-box domain. Only a few ... As a FOX protein, FOXP2 contains a forkhead-box domain. In addition, it contains a polyglutamine tract, a zinc finger and a ... Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead ... The forkhead box P2 protein is active in the brain and other tissues before and after birth, many studies show that it is ...
Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7] ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. ... 1989). "Complementary homeo protein gradients in developing limb buds". Genes Dev. 3 (5): 641-50. doi:10.1101/gad.3.5.641. PMID ... HOXD8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ...
... protein.[45] PPARα increases the activity of activator protein 1 (AP-1) and NF-κB, thereby leading to the recruitment of ... This article incorporates text from this source, which is in the public domain. ... The FDA-mandated black-box warning about tumorigenic potential of spironolactone, as it may increase certain tumors, which has ... These free radicals likely interfere with the bacterium's metabolism and ability to make proteins.[79][80] Additionally, ...
Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type ... Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.[5] ... Activation of normal PPARy targets due to the over expression of the chimeric protein that contain all functional domains of ... The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA.[6] This nuclear protein is ...
Protein domains in homologous recombination-related proteins are conserved across the three main groups of life: archaea, ... protein C-terminus binding. • protein binding. • four-way junction DNA binding. • identical protein binding. • ... Liu S, Li Y, Xu H, Wang K, Li N, Li J, Sun T, Xu Y (2016). "Increased expression of SET domain containing proteins and ... This protein can interact with the ssDNA-binding protein RPA, BRCA2, PALB2[10] and RAD52. ...
... and some protein domains-e.g., Tudor domains-can be specific for methyl arginine instead of methyl lysine. Arginine is known to ... The serotonylation potentiates the binding of the general transcription factor TFIID to the TATA box.[49] ... the C-domain, and to the N-terminal substrate recognition domain of Clp/Hsp100 proteins. Despite the differences in their ... who believed that transcription was activated by protein-DNA and protein-protein interactions on largely naked DNA templates, ...
"Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM ... encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma". EMBO J. 14 (10): 2333-40. PMC 398342 ... Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[3][4] ... This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding ...
FOXP2(Forkhead box protein P2 (FOXP2))基因,即叉头框P2基因,是一个与言语功能的发育有关的基因。在人类,FOXP2基因位于第7对染色体上。FOXP2基因在许多其它具有复杂发声、及发声学习能力的动物,例如鸣禽中,也有发 ... bZIP(英语:bZIP domain)). 转录激活因子(英语:Activating transcription factor)(AATF(英语:Apoptosis-antagonizing transcription factor)、1、2、3、
This protein is absent or reduced in embryonic extracts of nine of the 11 bcd alleles. The protein is concentrated in the ... Segment polarity genes are expressed and required in restricted domains within each metameric unit of the Drosophila embryo.. ... The recent isolation of homeotic genes and the discovery of the homeo box appear to be decisive steps toward the identification ... transcribed from the genes that encode bicoid protein and nanos protein.[3][4] These mRNA molecules are stored to be used later ...
Temporal protein biomarkers in tracking different phases of TBIEdit. A continuum of protein biomarkers in tracking different ... You can demonstrate that this text is in the public domain, or is already under a license suitable for Wikipedia. ... please follow the instructions for filing at the bottom of the box. ... These include dendritic protein microtubule-associated protein-2 (MAP-2) [137,138], brain-derived nerve growth factor (BDNF) [ ...
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. „Mol. Cell. Biol.". 19 (1), s. 635-45, 1999. PMID: ... Identification of a functional domain in a GADD45-mediated G2/M checkpoint. „J. Biol. Chem.". 275 (47), s. 36892-8, 2000. DOI: ... Towards a proteome-scale map of the human protein-protein interaction network. „Nature". 437 (7062), s. 1173-8, 2005. DOI: ... a b Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H. TOK-1, a novel p21Cip1-binding protein that ...
Bernstein PL, Herrick DJ, Prokipcak RD, Ross J (1992). "Control of c-myc mRNA half-life in vitro by a protein capable of ... Seth A, Alvarez E, Gupta S, Davis RJ (1992). "A phosphorylation site located in the NH2-terminal domain of c-Myc increases ... 3.2) Paired box. PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) ... RefSeq (protein). NP_002458.2. NP_001170823.1. Lokacija (UCSC) ... Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex ...
Ubiquitin-receptor proteins have an N-terminal ubiquitin-like (UBL) domain and one or more ubiquitin-associated (UBA) domains. ... The APC and the Skp1/Cul1/F-box protein complex (SCF complex) are the two key regulators of cyclin degradation and checkpoint ... The protein degradation processEdit. Ribbon diagram of ubiquitin, the highly conserved protein that serves as a molecular tag ... Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks ...
"Resistance" (R) proteins, encoded by R genes, are widely present in plants and detect pathogens. These proteins contain domains ... Lotze MT, Tracey KJ (April 2005). "High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal". Nature ... This leads to antiviral protein production, such as protein kinase R, which inhibits viral protein synthesis, or the 2′,5′- ... The cascade is composed of many plasma proteins, synthesized in the liver, primarily by hepatocytes. The proteins work together ...
This method is not very accurate since the composition of proteins varies greatly and proteins with none of these amino acids ... The concentration of a protein can be estimated by measuring the OD at 280 nm due to the presence of tryptophan, tyrosine and ... Spectrophotometry is an important technique used in many biochemical experiments that involve DNA, RNA, and protein isolation, ... Spectrophotometry is often used in measurements of enzyme activities, determinations of protein concentrations, determinations ...
Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene. This gene is a member of the paired box (PAX ... 1989). "Conservation of the paired domain in metazoans and its structure in three isolated human genes". EMBO J. 8 (4): 1183-90 ... PAX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274-8. doi: ...
C/EBP homologous protein 10), POU3F1 (POU domain, class 3, transcription factor 1, aka Oct-6), Areb6 (ZEB1, Zinc finger E-box ... All CAS protein family members have common structural characteristics.[6] CAS proteins have an amino terminal SH3 domain ... "Entrez Gene: Cas scaffolding protein family member 4".. *^ a b Tikhmyanova N, Little JL, Golemis EA (April 2010). "CAS proteins ... Cas scaffolding protein family member 4 is a protein that in humans is encoded by the CASS4 gene.[5] ...
Jenuwein T, Laible G, Dorn R, Reuter G (January 1998). "SET domain proteins modulate chromatin domains in eu- and ... Indeed, a bromodomain - a protein domain that specifically binds acetyl-lysine - is found in many enzymes that help activate ... In general, proteins fold into discrete units that perform distinct cellular functions, but some proteins are also capable of ... The first way is post translational modification of the amino acids that make up histone proteins. Histone proteins are made up ...
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7). *Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1) ... Nilotinib carries a black box warning in the United States for possible heart complications.[9][10] Contraindications include ... Crystal structure of Abl kinase domain (blue) in complex with nilotinib (red) ... "Cancer drug prevents build-up of toxic brain protein". MedicalXpress.com. 10 May 2013. Retrieved 11 April 2017.. ...
The S4 sub-pocket has three ligand binding domains: the "hydrophobic box", the "cationic hole" and the water site. Factor Xa ... Contributions of protein-protein and protein-membrane interactions toward complex formation". The Journal of Biological ... in the catalytic domain and a substitution (Glu102Lys) in the second EGF-like domain". British Journal of Haematology. 90 (4): ... The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require ...
The first of these is mental and behavioural health, which is a "domain that is understudied in China."[109] The second issue ... Wang, Yixuan (2015). "The Mystery Revealed-Intersectionality in the Black Box: An Analysis of Female Migrants' Employment ... This article incorporates public domain material from the Library of Congress Country Studies website http://lcweb2.loc.gov/frd ...
... and Dicer protein. *A PLAT domain within its C2-like domain; this domain, by analogy to other PLAT domain-bearing proteins, may ... The gene promoter region of ALOX5 contains 8 GC boxes but lacks TATA boxes or CAT boxes and thus resembles the gene promoters ... ALOX5 binds with the F actin-binding protein, coactin-like protein. Based on in vitro studies, this protein binding serves to ... protein kinase A (PKA), protein kinase C, Cdc2, and/or a Ca2+/calmodulin-dependent protein kinase; b) moves to bind with ...
"Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2". Mol. Cell. Biol. 19 (1): 635-45. doi:10.1128/mcb. ... "Identification of a functional domain in a GADD45-mediated G2/M checkpoint". J. Biol. Chem. 275 (47): 36892-8. doi:10.1074/jbc. ... protein binding. • cyclin-dependent protein serine/threonine kinase inhibitor activity. • ubiquitin protein ligase binding. • ... cyclin-dependent protein serine/threonine kinase activity. • protein kinase inhibitor activity. • protein kinase binding. • ...
This causes the receptor to activate multiple G-proteins. This in turn causes the Ga-subunit of the protein to activate a ... Spectral domain optical coherence tomography in macular diseases. Meyer, Carsten H.; Saxena, Sandeep; Sadda, SriniVas R. New ... In this example, each box (element) within this matrix would be connected to one photoreceptor. The photoreceptor in the centre ... Retinal development begins with the establishment of the eye fields mediated by the SHH and SIX3 proteins, with subsequent ...
Mijelin protein nula • Osteonektin • Protein C • Protein S • Proteoglikan • Serum amiloid P komponenta • Sialoglikoprotein ( ... Kim, H; Baumann H (1997). „Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells". J ... Schiemann WP, Bartoe JL, Nathanson NM (1997). „Box 3-independent signaling mechanisms are involved in leukemia inhibitory ... Glikoprotein 130 (takođe poznat kao gp130, IL6ST, IL6-beta ili CD130) je transmembranski protein. On je osnivački član klase ...
... also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the ... protein domain specific binding. • RNA polymerase II transcription factor activity, sequence-specific DNA binding. ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. ... "Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting". ...
Template:DNA and protein biosynthesis navs(edit talk links history)- Genetics ({{Protein biosynthesis navs}}, R) ... Category:Medicine navigational box footer templates ('navs'; ca. 42+1 P). related. *Category:Anatomy templates ...
Acetylation of cellular proteins is a well-established phenomenon in the regulation of protein function at the post- ... Nothing would have been easier than to insist that the tablet makers should market the drug in small tin boxes bearing the ... it was too late in the autumn of 1915 to reclaim the word which had already passed into the public domain. If the consuming ... Protein binding. 80-90%[1]. Metabolism. Liver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut ...
... a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a ... S Gupta, Davis R J, MAP kinase binds to the NH2-terminal activation domain of c-Myc, in FEBS Lett., vol. 353, nº 3, ottobre ... Rob M Ewing, Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, et al., Large-scale mapping of human protein-protein interactions ... p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression (PDF), in J. Biol. Chem., vol. 277, nº 35, agosto 2002 ...
In the domain of database theory, it is known that a database schema enjoys certain desirable properties if its underlying ... Patro, Rob; Kingsoford, Carl (2013), "Predicting protein interactions via parsimonious network history inference", ... or boxes, and its hyperedges are depicted as trees that have the vertices as their leaves.[17][18] If the vertices are ... "Multilevel hypergraph partitioning: applications in VLSI domain", IEEE Transactions on Very Large Scale Integration (VLSI) ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Proteins matched: F-box domain (IPR001810) This domain is found in the following proteins: Showing 121 to 140 of 106596 results ... Protein name. Species. Domain architecture. P0CG94 Probable F-box protein At4g22165. Arabidopsis thaliana (Mouse-ear cress). ...
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Protein name. Species. Domain architecture. O23360 Putative F-box/LRR-repeat protein At4g15060. Arabidopsis thaliana (Mouse-ear ... Putative F-box/kelch-repeat protein At4g34170. Arabidopsis thaliana (Mouse-ear cress). Loading... ...
A-box, The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 ... A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is ... KRAB (Kruppel-associated box) domain -A box.. The KRAB domain is a transcription repression module, found in a subgroup of the ... Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein ...
... present in a protein.,p>,a href=/help/family_and_domains_section target=_top>More...,/a>,/p>Family & Domainsi. Domains and ... MADS-box domain-containing proteinInterPro annotation. ,p>Information which has been generated by the UniProtKB automatic ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR002100 TF ... tr,A0A0D9XUZ0,A0A0D9XUZ0_9ORYZ MADS-box domain-containing protein OS=Leersia perrieri OX=77586 PE=4 SV=1 ...
... and domain binding to ubiquitin in protein degradation pathways. ... A scientific resource for the F-Box protein domain containing ... The F-Box domain is a 42-48 conserved amino acid domain found at the N-terminus of F-Box proteins. F-Box proteins act as ... Examples of Domain Proteins. Binding Examples. F-Box Domain Proteins. Binding Partners. C-terminal Binding Partners. ... The F-Box domain mediates interaction with SKP1, which links F-Box proteins to the core ubiquitin-ligase complex that is ...
Domain 3 protein. Ab161964 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA. Abcam provides… ... Recombinant Human F Box G - Domain 3 protein. See all F Box G - Domain 3 proteins and peptides. ... Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex ... This protein in other organisms (by gene name): Q96BD6 - Homo sapiens 2 * Q5TIH9 - Homo sapiens no matching PDB entries ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Domain. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ... Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase ... This protein in other organisms (by gene name): Q96A44 - Homo sapiens 1 * Q8BJI9 - Mus musculus no matching PDB entries ...
... present in a protein.,p>,a href=/help/family_and_domains_section target=_top>More...,/a>,/p>Family & Domainsi. Domains and ... MADS-box domain-containing proteinInterPro annotation. ,p>Information which has been generated by the UniProtKB automatic ... tr,V4SG26,V4SG26_9ROSI MADS-box domain-containing protein OS=Citrus clementina OX=85681 GN=CICLE_v10030142mg PE=4 SV=1 ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR033896 ...
Compare F-box and WD-40 domain protein 10 Biomolecules from antibodies-online from leading suppliers on Biocompare. View ... F-box and WD-40 domain protein 10 Biomolecules from antibodies-online. Clear ... F-box and WD-40 domain protein 10 Biomolecules from antibodies-online. ... F-box and WD-40 domain protein 10 Biomolecules from antibodies-online. ...
F-box and WD-40 domain protein 11)*CCDS: 24833.1, 36125, 70157, 70158*OMIM: F-BOX AND WD40 DOMAIN PROTEIN 11; FBXW11*Gene ... F-box and WD-40 domain protein 11. Synonyms: 2310065A07Rik, BTRC2, BTRCP2, Fbxw1b, HOS. Gene nomenclature, locus information, ...
A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity. Xiaomei Yan ... A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity ... A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity ... A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity ...
Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain. ... Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain. ... RNA-Binding Proteins; *Saccharomyces cerevisiae Proteins; Coiled Bodies/metabolism; Fungal Proteins/metabolism; RNA, Small ... Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit ...
Get highlights of the most important data releases, news and events, delivered straight to your email inbox. Subscribe to newsletter ...
The SSB family is comprised of four highly homologous proteins containing a C-terminal SOCS box motif and a central SPRY domain ... Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia. Molecular ... Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia. / Masters, ... title = "Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia", ...
Fluorescent Proteins, RNAi, Viral Packaging and Protein expression. ... F-box and WD-40 domain protein 7 isoform 2 (FBXW7) polyclonal antibody II. Orbigen $175.00 ... F-box and WD-40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody $175.00 ... F-box and WD-40 domain protein 7 isoform 2 (FBXW7) polyclonal antibody $175.00 ...
Inhibition of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions ... Inhibition of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions ... of polo-like kinase 1 by blocking Polo-box domain-dependent protein-protein interactions. Chemistry & Biology, 15(5), 459-466. ...
"T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of ... which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors ... "T-Box Domain Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... T-Box Domain Proteins*T-Box Domain Proteins. *Proteins, T-Box Domain ...
"T-Box Domain Proteins" by people in UAMS Profiles by year, and whether "T-Box Domain Proteins" was a major or minor topic of ... which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors ... "T-Box Domain Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles over the past ten years. ...
... box and WD_40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody \ ABP-PAB-10563 for more molecular products just contact ... 40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody. Related products : F_box and WD_40 domain protein 7 isoform 1 (FBXW7 ... 40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody / Product Detail : ABP-PAB-10563 F_box and WD_40 domain protein 7 ... F_box and WD_40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody antibody storage GENTAUR recommends for long therm ...
... antibody, rice, Oryza sativa, developmental biology ... U-box domain-containing protein 12 exhibits ligase activity and is involved in protein modifiction.. ... Home / Plant/Algal antibodies / Developmental biology / Signal transduction / U-box domain-containing protein 12 ... Total protein from Oryza sativa rice (CV. 9311) flag leaf at the tillering stage was ground into a fine powder in liquid ...
U-box domain-containing protein 27 - Also known as PUB27_ARATH, PUB27. Functions as an E3 ubiquitin ligase. ...
"Conserved Protein Domain Family TBOX, In: CDD/SPARCLE: functional classification of proteins via subfamily domain architectures ... GLM boxes · H boxes · H and ACA boxes · HMG boxes · HNFs · Homeoboxes · HY boxes · I boxes · Initiator elements · L boxes · M ... TACTAAC boxes · TATA binding protein · TATA binding protein associated factors · TATA boxes · TAT boxes · TATC boxes · T boxes ... AGC box laboratory · ATA box laboratory · C and D boxes laboratory · CArG box laboratory · CGCG box laboratory · CRE box ...
Protein Coding), B-Box And SPRY Domain Containing, including: function, proteins, disorders, pathways, orthologs, and ... Protein Symbol:. Q5W0U4-BSPRY_HUMAN. Recommended name:. B box and SPRY domain-containing protein. Protein Accession:. Q5W0U4. ... BSPRY (B-Box And SPRY Domain Containing) is a Protein Coding gene. Diseases associated with BSPRY include Kleefstra Syndrome 1 ... Protein Expression for BSPRY Gene. See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB ...
SPRY domain-containing SOCS box proteins SPSB1, 2, and 4 mediate the proteasomal degradation of inducible nitric oxide synthase ... SPRY domain-containing SOCS box proteins SPSB1, 2, and 4 mediate the proteasomal degradation of inducible nitric oxide synthase ... Molecular Insights into the Interaction Between the SPRY Domain-Containing SOCS Box Protein SPSB2 and Peptides Based on the ... aspects of the interaction between peptide and protein are still not fully understood. Here, our results from.. ...
Phylogenetic analysis of rice and Arabidopsis MADS-box proteins. Phylogenetic analysis of 173 MADS-box proteins from rice (75) ... Conserved Domain Database (CDD). *Conserved Domain Search Service (CD Search). *Structure (Molecular Modeling Database) ... Distribution of Conserved motifs in rice MADS-box proteins identified using MEME search tool. Schematic representation of ... Expression Analysis of MADS-box genes in rice. a) Hierarchical cluster display of expression profile for thirty seven MADS-box ...
2C) that lacked either the B30.2 domain (lane 2), the coiled-coil domain (lane 3), or the B box domain (lane 4). Only the ... PYRIN domains participate in homotypic protein-protein interactions and are found in a number of proteins involved in the ... The B box domain of pyrin is necessary for the interaction with PSTPIP1. (A) Schematic diagram of the structural domains of ... Pyrin is comprised of at least four major domains (Fig. 2A): a 92-aa N-terminal PYRIN domain, a B box zinc finger (amino acids ...
E-mail: zgliu{at}box-z.nih.gov.. *. Author contributions: Z.-G.L. designed research; J.Z., S.J., Z.C., and S.C. performed ... TRADD (TNF-R1-associated death domain protein) is the first protein to interact with the receptor through its death domain and ... Apoptosis is primarily initiated through the recruitment of the death domain protein FADD (Fas-associated death domain protein ... Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Jie Zhao ...
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis *John P. Wing ... Rights & permissionsfor article ,i,Drosophila,/i, Morgue is an F box/ubiquitin conjugase domain protein important for ,i,grim- ...
2cs4 PDB n-terminal domain chromosome 12 ORF 2.png 454 × 420; 123 KB. ... Protein (lb); protein (nb); Protéin (su); Protein (hif); 朊 (lzh); بروتين (ar); Protein (br); ပရိုတိန်း (my); 蛋白質 (yue); Белок ( ... प्रोटिन (dty); Prótín (is); Protein (ms); protein (tr); لحمیات (ur); Bielkovina (sk); білок (uk); 蛋白质 (zh-cn); Protein (gsw); ... protein (sco); Уураг (mn); protein (nn); ಪ್ರೋಟೀನ್ (kn); پرۆتین (ckb); protein (en); fehérje (hu); પ્રોટિન (gu); प्रोटिन (new); ...
  • Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF , however HGF treatment has a positive effect on this interaction (PubMed:15713673). (rcsb.org)
  • Here we report the identification of mixed lineage kinase domain-like, MLKL, as a key RIP3 downstream component of TNF-induced necrosis. (pnas.org)
  • The PHR proteins act as E3 ubiquitin ligases for the dual-leucine-zipper-bearing MAP kinase kinase kinase (DLK MAPKKK) to regulate the signal transduction cascade. (genetics.org)
  • 2. The method of claim 1, wherein the protein kinase C activator is selected from the group consisting of bradykinin, bryostatin, bombesin, cholecystokinin, thrombin, prostaglandin F2-alpha or vasopressin. (freepatentsonline.com)
  • Furthermore, the G q signaling pathway composed of G q α EGL-30 , diacylglycerol, and nPKC (novel protein kinase C) TTX-4 promotes attractive drive of ASER but not of ASEL . (genetics.org)
  • In this study, we establish that fibroblast growth factor (FGF) signals through mitogen-activated protein kinase kinase (MAPKK) to induce mesodermal gene expression. (biomedsearch.com)
  • Cyclin G-associated kinase is homologous in function to the protein auxilin which when in association with Hsc70 uncoats clathrin in neuronal cells. (wikipedia.org)
  • Cyclin G-associated kinase is a two domain cystolic protein. (wikipedia.org)
  • The other domain is the N terminal kinase domain which is a functional Ser/Thr protein kinase. (wikipedia.org)
  • The N-terminal kinase domain is able to phosphorylate histone H1. (wikipedia.org)
  • Without taking into account GAK's kinase domain, GAK is 43% identical to auxilin, a neuronal cell uncoating clathrin cofactor, in its amino acid composition. (wikipedia.org)
  • it prevented GlcN-induced decreases in glycogen content and the phosphoinositide 3-kinase (PI3K) p110α subunit level, and the phosphorylation of Akt/protein kinase B, forkhead box transcription factor O1 (FOXO1) and glycogen synthase kinase-3 (GSK3). (portlandpress.com)
  • PTK, the intracellular protein tyrosine kinase domain. (els.net)
  • shaded area , the extent of the kinase domain. (rupress.org)
  • These effects are mediated in part through cognate interactions with the adaptor protein ASC, which shares an N-terminal motif with pyrin. (pnas.org)
  • Like the latter three motifs, PYRIN domains participate in homotypic protein-protein interactions and are found in a number of proteins involved in the regulation of inflammation and apoptosis ( 8 - 12 ). (pnas.org)
  • Modulating protein-protein interactions: from structural determinants of binding to druggability prediction to application. (semanticscholar.org)
  • The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. (mdpi.com)
  • This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions. (mdpi.com)
  • Besides the F-box domain, other domains and motifs related to protein-protein interactions are usually present in the C -terminal region of FBPs, such as leucine rich repeats (LRR), WD40 repeats (WD), Kelch repeats, proline-rich and others. (mdpi.com)
  • Participants will be enabled to incorporate computer visualization and qualitative analysis of 3D structure of protein, DNA, RNA, and protein-ligand interactions into their teaching and research. (umass.edu)
  • Surprisingly, knock-in mice expressing a mutant isoform of IgSF9 lacking the entire cytoplasmic domain ( IgSF9 ΔC/ΔC mice) had no defects in inhibitory synapse development, providing genetic evidence that IgSF9 regulates synapse development via ectodomain interactions rather than acting itself as a signaling receptor. (jneurosci.org)
  • Well known examples include SLiMs that interact with 14-3-3, PDZ, SH2, SH3, and WW domains but the true extent and diversity of SLiM-mediated interactions is largely unknown. (rsc.org)
  • Often, this was due to the non-independence of the datasets, with many proteins sharing interaction partners or contributing interactions to multiple domain datasets. (rsc.org)
  • 8,9 They are known to mediate many important protein - protein interactions in a variety of scenarios, including protein scaffolding ( e.g. 14-3-3), intra- ( e.g. (rsc.org)
  • How to use Protein Explorer to visualize structural features of proteins and protein-ligand interactions. (umass.edu)
  • A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. (curehunter.com)
  • Overall, these complex WRKY protein domain-DNA interactions results in gene activation necessary for numerous aspects of plant development and defense. (wikipedia.org)
  • Recent work has provided novel insights into the mechanisms that contribute to their functional diversity, including functional protein domains and interactions of forkheads with other transcription factors. (biochemj.org)
  • [3] The activation of these proteins by Hox genes initiates signaling cascades that involve the Wnt signaling pathway and fibroblast growth factor (FGF) signals in limb buds. (wikiversity.org)
  • These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. (wikiversity.org)
  • Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors. (wikiversity.org)
  • It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. (wikiversity.org)
  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. (wikiversity.org)
  • T-box genes encode transcription factors involved in the regulation of developmental processes. (wikiversity.org)
  • Furthermore, owing to the role of MADS-box family in flower development, an analysis involving structure, expression and functional aspects of MADS-box genes in rice and Arabidopsis was required to understand the role of this gene family in reproductive development. (nih.gov)
  • A genome-wide molecular characterization and microarray-based expression profiling of the genes encoding MADS-box transcription factor family in rice is presented. (nih.gov)
  • Using a thorough annotation exercise, 75 MADS-box genes have been identified in rice and categorized into MIKCc, MIKC*, Malpha, Mbeta and Mgamma groups based on phylogeny. (nih.gov)
  • Chromosomal localization of these genes reveals that 16 MADS-box genes, mostly MIKCc-type, are located within the duplicated segments of the rice genome, whereas most of the M-type genes, 20 in all, seem to have resulted from tandem duplications. (nih.gov)
  • The expression profiles of all the MADS-box genes have been analyzed under 11 temporal stages of panicle and seed development, three abiotic stress conditions, along with three stages of vegetative development. (nih.gov)
  • An attempt has been made to gain insight into plausible functions of rice MADS-box genes by collating the expression data of functionally validated genes in rice and Arabidopsis. (nih.gov)
  • A comprehensive annotation and transcriptome profiling undertaken in this investigation adds to our understanding of the involvement of MADS-box family genes during reproductive development and stress in rice and also provides the basis for selection of candidate genes for functional validation studies. (nih.gov)
  • 75 MADS-box genes have been mapped on rice chromosomes according to 5' and 3' coordinates mentioned in TIGR. (nih.gov)
  • The genes which contain this motif are called the MADS-box gene family. (wikipedia.org)
  • MADS-box genes were detected in nearly all eukaryotes studied. (wikipedia.org)
  • [8] While the genomes of animals and fungi generally possess only around one to five MADS-box genes, genomes of flowering plants have around 100 MADS-box genes. (wikipedia.org)
  • A geneticist intensely investigating MADS-box genes is Günter Theißen at the University of Jena . (wikipedia.org)
  • MADS-box genes have a variety of functions. (wikipedia.org)
  • In animals, MADS-box genes are involved in muscle development and cell proliferation and differentiation. (wikipedia.org)
  • Some MADS-box genes of flowering plants have homeotic functions like the HOX genes of animals. (wikipedia.org)
  • [1] The floral homeotic MADS-box genes (such as AGAMOUS and DEFICIENS ) participate in the determination of floral organ identity according to the ABC model of flower development . (wikipedia.org)
  • Another function of MADS-box genes is flowering time determination. (wikipedia.org)
  • In Arabidopsis thaliana the MADS box genes SOC1 [20] and Flowering Locus C [21] ( FLC ) have been shown to have an important role in the integration of molecular flowering time pathways. (wikipedia.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • MADS-box genes are considered as the foundation of all agronomic traits because they play essential roles in almost every aspect of plant reproductive development. (frontiersin.org)
  • Keratin-like (K) domain is a conserved protein domain of tens of MIKC-type MADS-box genes in plants. (frontiersin.org)
  • K-domain technology constitutively expresses a K-domain to mimic expression of the K-domains of other MADS-box genes simultaneously and thus to generate new opportunities for yield enhancement, because the increased K-domains can likely prevent MADS-domain proteins from binding to target DNA. (frontiersin.org)
  • The K-domain of a blueberry's SUPPRESSOR of CONSTITUTIVE EXPRESSION OF CONSTANS 1 ( VcSOC1K ) has similarities to five MADS-box genes in maize. (frontiersin.org)
  • Transcriptome comparisons revealed 982 differentially expressed genes (DEGs) in the leaves from 83-day old plants, supporting that the K-domain technology were powerful and multiple functional. (frontiersin.org)
  • With the potential of mimicking the K-domains of multiple MADS-box genes, the K-domain technology opens a new approach to increase crop yield. (frontiersin.org)
  • This laid a foundation of the K-domain technology, which utilizes a constitutively expressing K-domain to mimic or affect the expression of multiple MADS-box genes simultaneously. (frontiersin.org)
  • FBXL5 is a subunit of an E3 ubiquitin ligase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptional regulator of several genes involved in iron metabolism. (elsevier.com)
  • Transcriptional cofactor KRAB domain-associated protein 1 (KAP1) has been shown to complex with the KRAB zinc finger protein, ZBRK1, to repress the transcription of target genes. (umn.edu)
  • MADS-box genes are categorized into A, B, C, D and E classes and are involved in floral organ identity and flowering. (springer.com)
  • In this study, we cloned 11 MADS-box genes from sheepgrass ( Leymus chinensis (Trin. (springer.com)
  • Tissue-specific expression profile analysis showed that most of these MADS-box genes were highly expressed in floral organs. (springer.com)
  • Previous studies indicated that some plant MADS-box genes are involved in abiotic stress responses. (springer.com)
  • Forkhead box (FOX) proteins have been shown to play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, longevity, and transformation. (aacrjournals.org)
  • We have investigated the role of FOX proteins in transducing Shh effects in human skin by using degenerate PCR to identify FOX genes differentially expressed in BCCs. (aacrjournals.org)
  • The WRKY domain is found almost exclusively in plants although WRKY genes appear present in some diplomonads, social amoebae and other amoebozoa, and fungi incertae sedis. (wikipedia.org)
  • Importantly, the WRKY genes contain a conserved intron in the WRKY domain, which occurs at the location encoding for the PR of the PRSYY amino acid sequence, thus explaining the conservation of this motif. (wikipedia.org)
  • To date, over 100 forkhead genes have been identified in a large variety of species, all sharing the evolutionary conserved 'forkhead' DNA-binding domain, and the cloning and characterization of forkhead genes have continued in recent years. (biochemj.org)
  • The upstream regions of both genes contain L1 box sequences (gray boxes) associated with putative WUS target sites (underlined). (biologists.org)
  • We show here that PROTODERMAL FACTOR2 ( PDF2 ), a member of the HD-GL2 class of homeobox genes, is expressed exclusively in the L1 of shoot meristems and that recombinant PDF2 protein specifically binds to the L1 box in vitro. (biologists.org)
  • Given the functional significance of individual members of the homeodomain proteins in plant growth and development, their target DNA sequences and downstream genes must be investigated further. (biologists.org)
  • The L1 box is well-conserved within the promoter regions of all L1-specific genes analyzed so far. (biologists.org)
  • This protein is a transcription factor, which means that it controls the activity of other genes. (medlineplus.gov)
  • It attaches (binds) to the DNA of these genes through a region known as a forkhead domain. (medlineplus.gov)
  • Researchers suspect that the forkhead box P2 protein may regulate hundreds of genes, although only some of its targets have been identified. (medlineplus.gov)
  • Researchers are working to identify the genes regulated by forkhead box P2 that are critical for learning these skills. (medlineplus.gov)
  • Because forkhead box P2 is a transcription factor, these changes affect the activity of other genes in the developing brain. (medlineplus.gov)
  • The human Y-box-binding protein, YB-1, which is located on chromosome 1p34, ( 23 , 41 ) was initially identified as a transcriptional factor which associates with the Y-box sequence appearing in the major histocompatibility complex class II genes ( 5 ). (asm.org)
  • In this study, we report the identification of a domain cassette (DC) present in group A var genes from six genetically distinct P. falciparum parasites. (jimmunol.org)
  • This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. (novusbio.com)
  • A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). (nih.gov)
  • Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit through Cajal bodies (CB). (cnrs.fr)
  • The SSB family is comprised of four highly homologous proteins containing a C-terminal SOCS box motif and a central SPRY domain. (monash.edu)
  • In recent years, there have been reports on genomic localization, protein motif structure, phylogenetic relationships, gene structure and expression of the entire MADS-box family in the model plant system, Arabidopsis. (nih.gov)
  • The N-terminal ≈90 amino acids of pyrin define a motif, variously called the PYRIN domain ( 8 ), PYD ( 9 , 10 ), PAAD ( 11 ), or DAPIN ( 12 ), which is similar in structure to death domains, death effector domains, and caspase recruitment domains (CARDs). (pnas.org)
  • The MADS box is a conserved sequence motif . (wikipedia.org)
  • The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T] 6 GG termed the CArG-box. (wikipedia.org)
  • The domain is characterized by a highly conserved core WRKYGQK motif and a zinc finger region. (wikipedia.org)
  • Eighteen amino acids are highly conserved in the WRKY protein domain, including the core motif, zinc-finger binding cysteines and histidines, and a triad forming a DWK salt bridge. (wikipedia.org)
  • The triad consist of a conserved tryptophan (W) of the core motif, along with an aspartic acid (D) four amino acids upstream and a lysine (K) 29 amino acids downstream of it, stabilizing the entire domain. (wikipedia.org)
  • The RKYGQK residues of the core motif and additional arginine and lysine residues of the WRKY domain are responsible for interaction with the phosphate backbone of seven consecutive DNA base pairs, including the GAC core. (wikipedia.org)
  • Changing the tryptophan, tyrosine, or either lysine of the WRKYGQK motif to alanine completely abolishes DNA-binding, indicating these amino acids are essential for recognizing the W-box element. (wikipedia.org)
  • While not essential, altering the WRKYGQK motif arginine, glycine or glutamine to alanine reduces DNA-binding to the W-box. (wikipedia.org)
  • Our previous study demonstrated that an 8-bp motif named the L1 box functions as a cis-regulatory element for L1-specific gene expression in the shoot system of Arabidopsis . (biologists.org)
  • B) A diagram of DP103, denoting eight highly conserved motifs within the N-terminal region of DEAD-box family proteins as well as the nonconserved C-terminal region. (asm.org)
  • The nuclear DELLA proteins are highly conserved repressors of hormone gibberellin (GA) signaling in plants. (plantcell.org)
  • While the WRKYGQK is highly conserved in most WRKY domains, variation in the core sequence has been documented. (wikipedia.org)
  • The DBD and LBD consist of a highly conserved DNA-binding domain and a moderately conserved ligand-binding domain, respectively. (hindawi.com)
  • Forkhead proteins comprise a highly conserved family of transcription factors, named after the original forkhead gene in Drosophila . (biochemj.org)
  • Here, we identify the LIN gene in Medicago truncatula and Lotus japonicus , showing that it codes for a predicted E3 ubiquitin ligase containing a highly conserved U-box and WD40 repeat domains. (plantphysiol.org)
  • The Y-box protein family, which is widely distributed from bacteria to mammals, contains a cold shock domain, which is highly conserved from prokaryotic cold shock proteins. (asm.org)
  • Nicholson, S. E. / Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia . (monash.edu)
  • SPRY domain-containing SOCS box proteins SPSB1, 2, and 4 mediate the proteasomal degradation of inducible nitric oxide synthase (iNOS) and thereby modulate the amount of NO available for combating infectious organisms. (edu.au)
  • In Arabidopsis , Kelch repeats are the most common domain found in FBPs. (mdpi.com)
  • However, most of the predicted FBPs in Arabidopsis lack any other extra domain [ 6 ]. (mdpi.com)
  • In Arabidopsis thaliana , GA derepresses its signaling pathway by inducing proteolysis of the DELLA protein REPRESSOR OF ga1-3 (RGA). (plantcell.org)
  • 30 GRAS proteins, all of which demonstrate high sequence similarity in their C-terminal GRAS domain ( Arabidopsis Genome Initiative, 2000 ). (plantcell.org)
  • Arabidopsis PROTODERMAL FACTOR 1 ( PDF1 ) encodes a proline-rich cell-wall protein that is expressed exclusively in the L1 of shoot meristems. (biologists.org)
  • F-Box proteins act as modular E3 ubiquitin ligase adaptor proteins within the SCF complex responsible for phosphorylation-mediated ubiquitination. (cellsignal.com)
  • The F-Box domain mediates interaction with SKP1, which links F-Box proteins to the core ubiquitin-ligase complex that is composed of Rbx1, cdc53/Cul1 and the E2 conjugating enzyme cdc34. (cellsignal.com)
  • Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (abcam.com)
  • Substrate recognition component of a SCF-like ECS (Elongin BC- CUL2 /5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). (rcsb.org)
  • Component of the probable ECS( SPSB1 ) E3 ubiquitin-protein ligase complex which contains CUL5 , RNF7 /RBX2, Elongin BC complex and SPSB1 (PubMed:15601820). (rcsb.org)
  • Probable component of the ECS( SPSB4 ) E3 ubiquitin-protein ligase complex which contains CUL5 , RNF7 /RBX2, Elongin BC complex and SPSB4 (PubMed:15601820). (rcsb.org)
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. (rcsb.org)
  • These studies reveal that a major function of PHR proteins is to act as ubiquitin E3 ligases ( J in and G arner 2008 ). (genetics.org)
  • Small protein tags such as ubiquitin have also been shown to control the activation of kinases. (genetics.org)
  • Most of the characterized FBPs are components of the SCF (SKp1, Cullin, F-box protein) E3 ubiquitin-ligase complex. (mdpi.com)
  • The SCF E3 ubiquitin-ligase complex participates in the recognition and recruitment of target proteins for ubiquitination and degradation by the ubiquitin 26S proteasome system (UPS). (mdpi.com)
  • Both β-TrCP2 ( Fbxw11 ) and β-TrCP1 ( Btrc ) are E3 ubiquitin protein ligase complex subunits involved in the regulation of multiple cellular processes via phosphorylation-dependent ubiquitination/degradation of various targets including β-catenin (effector of the Wnt pathway), IκB (inhibitor of NF-κB pathway), cell cycle regulators (CDC25A, WEE1, Emi1, Bora) and DNA damage responsive proteins (CDC25A and Claspin). (jax.org)
  • They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. (curehunter.com)
  • They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS. (curehunter.com)
  • Ubiquitin-mediated protein degradation is a universal mechanism to regulate many biological processes by eliminating rate-limiting enzymes and key components such as transcription factors. (plantphysiol.org)
  • It is known that receptor interacting protein (RIP) kinases, RIP1 and RIP3, are key effectors of TNF-induced necrosis, but little is known about how these two RIP kinases mediate this process, although reactive oxygen species (ROS) generation and JNK activation have been suggested to be two downstream events of RIP kinases. (pnas.org)
  • TRADD (TNF-R1-associated death domain protein) is the first protein to interact with the receptor through its death domain and recruits other effector proteins, such as RIP1 (receptor interacting protein) and TRAF2 (TNFR-associated factor 2) to form the TNF-R1 signaling complex leading to the activation of several pathways, including NF-κB and MAP kinases ( 1 , 2 ). (pnas.org)
  • In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. (wikipedia.org)
  • Among these checkpoint components are protein kinases and phosphoproteins suggesting that checkpoint function requires a phosphorylation-based transduction pathway. (rupress.org)
  • Analysis of its overexpression in mad , bub , and mps1 mutants suggests that the Bub1 and Mps1 kinases act together at an early step in the checkpoint pathway, upstream of all the other Bub and Mad proteins ( Farr and Hoyt, 1998 ). (rupress.org)
  • Gene ID: 6862 is TBXT T-box transcription factor T. "The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. (wikiversity.org)
  • HMG-box proteins are involved in various nuclear functions, including modulating chromatin structure and genomic stability. (elsevier.com)
  • The structure of the WRKY protein domain was first determined in 2005 using nuclear magnetic resonance (NMR) and later by crystallography. (wikipedia.org)
  • The conserved domains of HOLI (ligand binding domain of hormone receptors) domain and ZnF_C4 (C4 zinc finger in nuclear in hormone receptors) are essential for keeping basic roles of PPAR gene family, and the variant domains of LCRs may be responsible for their divergence in functions. (hindawi.com)
  • Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. (nih.gov)
  • The high-mobility-group (HMG)-box domain represents a very versatile protein domain that mediates the DNA-binding of non-sequence-specific and sequence-specific proteins. (elsevier.com)
  • The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. (mdpi.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • NP_003172.1 T-box transcription factor T isoform 1. (wikiversity.org)
  • NP_001257413.1 T-box transcription factor T isoform 2. (wikiversity.org)
  • NP_001353214.1 T-box transcription factor T isoform 3. (wikiversity.org)
  • NP_542377.1 T-box transcription factor TBX1 isoform A. (wikiversity.org)
  • XP_016884414.1 T-box transcription factor TBX1 isoform X1. (wikiversity.org)
  • Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). (cancerindex.org)
  • Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients. (cancerindex.org)
  • In previous work, we and others have established that activation of Shh signaling, by mutational inactivation of the Shh receptor PTCH1 (9) , activating mutation of the PTCH1-binding G-protein-coupled receptor SMO (10) , or up-regulation of a Shh target transcription factor Gli1 (11 , 12 , 13 , 14) , plays a key role in the development of the common Caucasian skin cancer, BCC. (aacrjournals.org)
  • Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene . (wikidoc.org)
  • The WRKY domain is found in the WRKY transcription factor family, a class of transcription factors. (wikipedia.org)
  • Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). (rush.edu)
  • The FMF gene, MEFV , encodes a 781-aa protein denoted pyrin (or marenostrin) ( 3 , 4 ), which is expressed primarily in neutrophils, eosinophils, and cytokine-activated monocytes ( 5 , 6 ). (pnas.org)
  • [1] The MADS box encodes the DNA-binding MADS domain. (wikipedia.org)
  • We identified the mutation in arc6 and show that the ARC6 gene encodes a chloroplast-targeted DnaJ-like protein localized to the plastid envelope membrane. (plantcell.org)
  • SLEEPY1 ( SLY1 ) encodes an F-box-containing protein, and the loss-of-function sly1 mutant has a GA-insensitive dwarf phenotype and accumulates a high level of RGA. (plantcell.org)
  • 1991) The candidate gene for the X‐linked Kallmann syndrome encodes a protein related to adhesion molecules. (els.net)
  • The gene sup-9 of the nematode Caenorhabditis elegans encodes a two-pore domain K + channel [28] . (prolekare.cz)
  • This gene encodes a member of the paired box (PAX) family of transcription factors. (novusbio.com)
  • We report that in yeast, overexpression of a box C/D reporter leads to a block in the localization pathway with snoRNA accumulation in a specific sub-nucleolar structure, the nucleolar body (NB). (cnrs.fr)
  • Protein localization in disease and therapy. (semanticscholar.org)
  • We tested whether the regional localization of bone morphogenetic protein-4 (BMP-4) could explain why both MAPKKD and delta FGFR eliminate the dorsal and not the ventral expression of Xcad-3 and Xbra. (biomedsearch.com)
  • We show here that arc6 chloroplasts also exhibit abnormal localization of the key plastid division proteins FtsZ1 and FtsZ2. (plantcell.org)
  • The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. (nih.gov)
  • Interaction was detected by using a mammalian two-hybrid assay, with SF-1 120-462 fused downstream from GAL4 and DP103 fragments (as shown) fused to the VP16 activation domain. (asm.org)
  • 100 µ g) FBXW7 is a member of the FBXS proteins that contain either different protein-protein interaction modules or no recognizable motifs. (allelebiotech.com)
  • Although crystal structures of SPSB complexes with DINNN peptides are available, aspects of the interaction between peptide and protein are still not fully understood. (edu.au)
  • The B box segment of pyrin was necessary and the B box/coiled-coil segment sufficient for this interaction, whereas the SH3 and coiled-coil domains of PSTPIP1/CD2BP1 were both necessary, but neither was sufficient, for pyrin binding. (pnas.org)
  • UEV-3 can bind PMK-3 in heterologous protein interaction assays. (genetics.org)
  • DBC1 inhibits Sirt1 activity in part by blocking the ESA-deacetylase domain interaction 34 . (nature.com)
  • The F-box domain consists of a conserved sequence of about 50 amino acids implicated in the interaction with core members of the complex [ 1 , 10 , 11 ]. (mdpi.com)
  • The C-terminal J domain is responsible for the interaction with Hsc70, which is a molecular chaperone responsible for the uncoating of clathrin-coated vesicles during endocytosis. (wikipedia.org)
  • Combining data from seven different interaction databases, we analysed approximately 6000 protein -centred and 1600 domain-centred human interaction datasets of 3+ unrelated proteins that interact with a common partner. (rsc.org)
  • 1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element" . (wikidoc.org)
  • However, we found that this DELLA domain is not required for protein-protein interaction with SLY1 in yeast ( Saccharomyces cerevisiae ), suggesting that its role is in a GA-triggered conformational change of the DELLA proteins. (plantcell.org)
  • This effect of sly1-d appears to be caused by an enhanced interaction between sly1-d and the DELLA proteins. (plantcell.org)
  • Unexpectedly, TonB2 did not bind in vitro to the FatA TonB-box region, suggesting that additional factors may be required to promote this interaction. (biochemj.org)
  • Recent evidence suggests that the GAC core of the W-box is the primary target of the WRKY domain and flanking sequences help dictate DNA interaction with very specific WRKY proteins. (wikipedia.org)
  • Interaction of the PDF2 gene product with the L1 box in vitro. (biologists.org)
  • The direct interaction of YB-1 and IRP2 provides the first evidence of the involvement of YB-1 in the translational regulation of an iron-related protein. (asm.org)
  • Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. (novusbio.com)
  • Pax family proteins typically contain a paired box domain and a paired-type homeodomain. (novusbio.com)
  • Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal domain (CTD) of Sirt1. (nature.com)
  • We also show that ZENK protein binds in vivo to the syn3 promoter. (jneurosci.org)
  • The zinc finger binds a Zn+2 ion, which is required for protein function. (wikipedia.org)
  • The N-terminal DELLA domain of RGA previously was shown to be essential for GA-induced degradation. (plantcell.org)
  • Edman degradation, in combination with protein sequencing of the SH high-molecular-weight complex, established a subunit stoichiometry of HoxFUYHI 2 . (asm.org)
  • reverse, 5′gtcctcatgtargccttgtagt3′) were designed based on a conserved domain within synapsin 2 ( syn2 ) mRNA sequences from several species in GenBank. (jneurosci.org)
  • Hypomethylation of ZNF423 regulatory sequences and BMP2 signaling result in transactivation of ZNF423α and a novel ZNF423β -isoform encoding a nucleosome remodeling and histone deacetylase complex-interacting domain. (rupress.org)
  • A ) Alignment of Bub1 protein sequences from S . pombe ( sp ), S . cerevisiae ( sc ), and mouse ( m ). (rupress.org)
  • Through this N-terminal domain, pyrin interacts with apoptosis-associated speck-like protein with a CARD (ASC) ( 13 ), a bipartite adaptor molecule comprised of an N-terminal PYRIN domain and a C-terminal CARD ( 14 ). (pnas.org)
  • It is known that the binding of TNF homotrimer to TNF-receptor 1 (TNF-R1) initiates the formation of TNF-R1 signaling complex by recruiting several adaptor/effector proteins. (pnas.org)
  • These proteins are transcription factors that control developmental pathways. (rush.edu)
  • The N termini of GRAS proteins are in general divergent and probably specify their diverse roles in different cellular pathways. (plantcell.org)
  • No function has yet been ascribed to any member of this family in mammalian species despite a clear role for other SOCS proteins in negative regulation of cytokine signaling. (monash.edu)
  • Here we present the atomic structure of theFBXL5Nterminus, a hemerythrin-likeα-helical bundle fold not previously observed in mammalian proteins. (elsevier.com)
  • Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor. (elsevier.com)
  • FBPs from plants have additional domains, but their identity and distribution are consistently different from their mammalian counterparts. (mdpi.com)
  • and a region similar to the mammalian StAR-related lipid-transfer (START) domain ( Ponting and Aravind, 1999 ). (biologists.org)
  • In this day of exploding bioinformatics information from genomics and proteomics, it is ever more important to be conversant with macromolecular three-dimensional structure, and how it relates to protein and nucleic acid function and drug design. (umass.edu)
  • Advanced glycation end products (AGEs), a group of compounds that are formed by non-enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of proteins, lipids or nucleic acids, can be obtained exogenously from diet or formed endogenously within the body. (springer.com)
  • The membrane proteins that carry out these lipid translocation processes are classified into two categories based on whether the lipid transportation across the bilayer is driven by ATP ( Pomorski and Menon, 2006 , 2016 ). (frontiersin.org)
  • In eukaryotes, many secretory and membrane proteins fold via disulfide bond formation in the endoplasmic reticulum (ER). (plantphysiol.org)
  • We identified and classified a CBS domain-containing protein superfamily in soybean. (mdpi.com)
  • We used a genetic approach in mice to identify the Ig superfamily member IgSF9/Dasm1 as a candidate homophilic synaptic adhesion protein that regulates inhibitory synapse development. (jneurosci.org)
  • DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. (harvard.edu)
  • Plk1 localizes to its intracellular anchoring sites via its polo-box domain (PBD). (semanticscholar.org)
  • While genetic variation contributes to structural alterations in proteins, differences in gene expression can provide an additional means of varying cellular composition and cell responses. (weigelworld.org)
  • It has also been demonstrated that eukaryotic Y-box proteins regulate gene expression at translational levels by recognizing RNA ( 25 , 36 ). (asm.org)
  • The protein product of the NF1 gene neurofibromin is a guanosine triphosphatase (GTPase)-activating protein (GAP) that can negatively regulate p21ras signaling ( 5 ). (sciencemag.org)
  • The murine MSY1 protein and chicken Y-box protein both regulate transcription and translation ( 18 , 37 ). (asm.org)
  • Since two-pore domain K + channels regulate the resting membrane potentials of numerous cell types, we suggest that the SUP-18 IYD regulates the activity of the SUP-9 channel using NADH as a coenzyme and thus couples the metabolic state of muscle cells to muscle membrane excitability. (prolekare.cz)
  • The FOXP2 gene provides instructions for making a protein called forkhead box P2. (medlineplus.gov)
  • The forkhead box P2 protein is active in several tissues, including the brain, both before and after birth. (medlineplus.gov)
  • The forkhead box P2 protein appears to be essential for the normal development of speech and language. (medlineplus.gov)
  • A forkhead-domain gene is mutated in a severe speech and language disorder. (medlineplus.gov)
  • Recombinant protein encompassing a sequence within the center region of human PAX8. (novusbio.com)
  • The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. (nih.gov)
  • The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation. (nih.gov)
  • The T-box family is an ancient group that appears to play a critical role in development in all animal species. (wikiversity.org)
  • This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. (wikiversity.org)
  • MADS-box gene family in rice: genome-wide identification, organization and expression profiling during reproductive development and stress. (nih.gov)
  • Though there have been some studies in rice as well, an analysis of the complete MADS-box family along with a comprehensive expression profiling was still awaited after the completion of rice genome sequencing. (nih.gov)
  • The first MADS-box gene to be identified was ARG80 from budding yeast, Saccharomyces cerevisiae , [9] but was at that time not recognized as a member of a large gene family. (wikipedia.org)
  • F-box proteins (FBPs) are a large and diverse family of proteins present in all eukaryotes that are characterized by presence of the F-box domain [ 1 ]. (mdpi.com)
  • Motifs conserved in the DEAD box family cluster in the cleft between domains, and many of their functions can he deduced by mutational data and by comparison with other helicase structures. (caltech.edu)
  • Human DNA-binding protein (dbpA) is a member of a Y-box binding protein family containing a cold shock domain. (thermofisher.com)
  • Furthermore, the Y-box family proteins, Xenopus mRNP3/mRNP4 and mouse MSY2, are also found as mRNA-masking proteins in germinal cells ( 10 , 12 , 24 ). (asm.org)
  • This has been linked to parasites expressing the structurally related group A subset of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of IE adhesion ligands and to IEs with affinity for ICAM-1. (jimmunol.org)
  • Pax3 belongs to the family of paired box transcription factors. (novusbio.com)
  • We have determined the structure of a DEAD box putative RNA helicase from the hyperthermophile Methanococcus jannaschii, Like other helicases, the protein contains two alpha/beta domains, each with a recA-like topology. (caltech.edu)
  • In an attempt to create a model of Parkinson's disease (PD) eighty-three proteins were extracted from the Swiss- Prot protein database that had some casual mention of PD. (omicsonline.org)
  • The Swiss-Prot human protein database was downloaded from the EBI website on 29th October 2014. (omicsonline.org)
  • Four transmembrane/two-pore domain K + channels play a key role in establishing the resting membrane potentials of many cell types and in modulating their responses to neurotransmitters and second messengers [14] - [16] . (prolekare.cz)
  • The human survival of motor neuron protein (SMN), a marker of gems/CB, specifically localizes to the NB when expressed in yeast, supporting similarities between these structures. (cnrs.fr)
  • In mammal and yeast, the LLR and WD domains are frequently found. (mdpi.com)
  • By yeast two-hybrid and in vitro pull-down assays, we demonstrated that SLY1 interacts directly with RGA and GA INSENSITIVE (GAI, a closely related DELLA protein) via their C-terminal GRAS domain. (plantcell.org)
  • In addition to gross alterations in spindle structure, the budding yeast spindle checkpoint can also respond to low doses of microtubule depolymerizing drugs, to defects induced by mutations in centromere-binding proteins or in centromeric DNA, and to aberrantly segregating centromeres (for review see Rudner and Murray, 1996 ). (rupress.org)
  • Antisense inhibition of endogenous BACE messenger RNA decreased the amount of β-secretase cleavage products, and purified BACE protein cleaved APP-derived substrates with the same sequence specificity as β-secretase. (sciencemag.org)
  • KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. (nih.gov)
  • In addition to True Positive results for at least 25 different known SLiMs, a striking number of "off-target" proteins /domains also returned significantly enriched known motifs. (rsc.org)
  • The range of functions a protein can carry out is closely linked to the number of modules it contains, be they domains, 1-3 short linear motifs (SLiMs or LMs), 4,5 or other molecular recognition features (MoRFs). (rsc.org)
  • Many of the specific functions of intrinsically disordered protein segments are mediated by Short Linear Motifs (SLiMs). (rsc.org)
  • Box C/D snoRNA accumulation in the NB was decreased by mutation of Srp40 and increased by mutation of Nsr1p, two related nucleolar proteins that are homologous to human Nopp140 and nucleolin, respectively. (cnrs.fr)
  • This signaling cascade further regulates the activity of the CCAAT/enhancer binding protein (C/EBP), CEBP-1 , via a mechanism involving 3′-UTR-mediated mRNA decay. (genetics.org)
  • Sirt1 is an NAD + -dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. (nature.com)
  • Ann, David K. / Doxorubicin down-regulates Krüppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21 WAF1/CIP1 in Breast cancer MCF-7 cells . (umn.edu)
  • The rabbit Y-box protein, p50, which is 97% identical to human YB-1, is found in cytoplasmic messenger ribonucleoprotein particles (mRNP) in somatic cells and regulates translation by interacting with mRNA ( 7 ). (asm.org)
  • Experienced participants are encouraged to work at their own speed, ahead of the group -- there is plenty of power to discover within Protein Explorer and its connections to complementary structural bioinformatics resources! (umass.edu)
  • 1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter" . (wikidoc.org)
  • Interacts with YWHAZ/14-3-3 protein zeta (By similarity). (genecards.org)
  • We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin. (pnas.org)
  • 1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins" . (wikidoc.org)
  • In this report, we provide new insight into the molecular mechanism of how SLY1 interacts with the DELLA proteins for controlling GA response. (plantcell.org)
  • The F-Box domain is a 42-48 conserved amino acid domain found at the N-terminus of F-Box proteins. (cellsignal.com)
  • This placed stop codons in all three reading frames at codon 153 and deleted codons 154-212 (thus removing all but four amino acids of the F box plus an additional 22 amino acid region downstream of the F box). (jax.org)
  • The cysteine and histidine zinc finger domain occurs as a CX4-5CX22-23HXH or CX7CX23HXC type, where X can be any amino acid. (wikipedia.org)
  • B) The predicted amino acid sequence of the PDF2 protein. (biologists.org)
  • These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. (nih.gov)
  • T-box transcription factors, T-box expressed in T cells (T-bet) encoded by Tbx21 and Eomesodermin (Eomes), drive the differentiation of effector/memory T cell lineages and NK cells. (cancerindex.org)
  • A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. (nih.gov)
  • The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. (harvard.edu)
  • In C. elegans, loss-of-function of the PHR protein RPM-1 (Regulator of Presynaptic Morphology-1) results in fewer synapses, disorganized presynaptic architecture, and axon overextension. (genetics.org)
  • We propose that LIN is a regulator of the component(s) of the nodulation factor signal transduction pathway and that its function is required for correct temporal and spatial activity of the target protein(s). (plantphysiol.org)
  • The subdomain tension-like N terminal function has not yet determined, though the domain shares high homology to the tumor suppressant PTEN. (wikipedia.org)
  • the results showed that YB-1 itself, iron-regulatory protein 2 (IRP2), and five ribosomal proteins each served as partners to YB-1. (asm.org)
  • F_box and WD_40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of F_box and WD_40 domain protein 7 isoform 1 (FBXW7) polyclonal antibody. (antibody-antibodies.com)
  • This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. (wikiversity.org)
  • It has been well established that the PPARs can be divided into five distinct functional regions, which include DBD (DNA-binding domain), LBD (ligand-binding domain), AF1 (activation function 1), AF2 (activation function 2), and a variable hinge region. (hindawi.com)
  • However, there are few studies on the molecular mechanisms of flower development in sheepgrass, especially studies on MADS-domain proteins. (springer.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore domain K + channel associated with muscle membranes. (prolekare.cz)
  • Thus, synapsins are candidate ITF targets, but their in vivo regulation in a manner dependent on early protein synthesis has not been shown. (jneurosci.org)