A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
A condition in which HEART VENTRICLES exhibit impaired function.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Contractile activity of the MYOCARDIUM.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
The hollow, muscular organ that maintains the circulation of the blood.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
The hemodynamic and electrophysiological action of the LEFT ATRIUM.
Elements of limited time intervals, contributing to particular results or situations.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The circulation of blood through the CORONARY VESSELS of the HEART.
A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The chambers of the heart, to which the BLOOD returns from the circulation.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Examinations used to diagnose and treat heart conditions.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
The span of viability of a tissue or an organ.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
The valve between the left atrium and left ventricle of the heart.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
The veins and arteries of the HEART.
Drugs used to cause dilation of the blood vessels.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Surgery performed on the heart.
A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
Insurance coverage of a physical or mental health condition, disability, or illness existing before health insurance is applied for or enrolled in.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
The pressure within the CARDIAC ATRIUM. It can be measured directly by using a pressure catheter (see HEART CATHETERIZATION). It can be also estimated using various imaging techniques or other pressure readings such as PULMONARY CAPILLARY WEDGE PRESSURE (an estimate of left atrial pressure) and CENTRAL VENOUS PRESSURE (an estimate of right atrial pressure).
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Disease having a short and relatively severe course.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The period following a surgical operation.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
Physiological disturbances in normal sexual performance in either the male or the female.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The innermost layer of the heart, comprised of endothelial cells.
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The condition of an anatomical structure's being dilated beyond normal dimensions.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.
A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Motion pictures of the passage of contrast medium through blood vessels.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Shock resulting from diminution of cardiac output in heart disease.
Diseases that do not exhibit symptoms.
A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Agents that promote the excretion of urine through their effects on kidney function.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The measurement of an organ in volume, mass, or heaviness.
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
... leaving an abnormally elevated volume of blood in the left ventricle. In diastolic dysfunction, the end-diastolic ventricular ... This type is also known as heart failure due to left ventricular systolic dysfunction or systolic heart failure. This type of ... Diastolic dysfunction can be caused by processes similar to those that cause systolic dysfunction, particularly causes that ... Systolic dysfunction[edit]. Heart failure caused by systolic dysfunction is more readily recognized. It can be simplistically ...
Worse outcomes have been seen when echocardiography shows left ventricular wall thickness, poor systolic function and severe ... diastolic dysfunction.[1] For light-chain amyloidosis early detection leads to best possibility of therapies prolonging the ... Right heart catheterization is the test used to test for elevated diastolic ventricular pressures. This test is more invasive ... Amyloid deposition in the heart can cause both diastolic and systolic heart failure.[5] ...
In addition, CRS has been observed in patients with diastolic dysfunction who have normal left ventricular systolic function. ... "acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other". The heart and the kidneys are ... History of heart failure with impaired left ventricular ejection fraction Prior myocardial infarction Elevated New York Heart ... However, several studies did not find an association between kidney dysfunction and cardiac output or other hemodynamic ...
Diastolic dysfunction is an early consequence of hypertension-related heart disease and is exacerbated by left ventricular ... Patients with diastolic heart failure have a preserved ejection fraction, which is a measure of systolic function. ... May 2007). "[Left ventricular diastolic function and dysfunction: a single cardiac target for various systemic diseases]". ... "Utility of B-natriuretic peptide in the evaluation of left ventricular diastolic function and diastolic heart failure". Current ...
It is almost always indicative of left ventricular systolic impairment, and carries a poor prognosis. One explanation is that ... in left ventricular dysfunction, the ejection fraction will decrease significantly, causing reduction in stroke volume, hence ... causing an increase in end-diastolic volume. As a result, during the next cycle of systolic phase, the myocardial muscle will ... Inflate the blood pressure cuff past systolic pressure and then slowly lower cuff pressure towards the systolic level. If ...
... seen as a result of beta thalassemia and iron overload include left ventricular systolic and diastolic dysfunction, pulmonary ... systolic ejection murmur in the presence of severe anemia and pathologic fractures. Based on symptoms, tests are ordered for a ...
CHF in the setting of AS is due to a combination of left ventricular hypertrophy with fibrosis, systolic dysfunction (a ... resulting in a diastolic dysfunction. As a result, there may be a fourth heart sound due to the stiff ventricle. With continued ... which is not displaced unless systolic dysfunction of the left ventricle has developed A precordial thrill narrowed pulse ... ECG manifestations of left ventricular hypertrophy (LVH) are common in aortic stenosis and arise as a result of the stenosis ...
... hypertension secondary to left heart disease Left ventricular systolic dysfunction Left ventricular diastolic dysfunction ... If it is caused by left heart disease, the treatment is to optimize left ventricular function by the use of medication or to ... with systolic ventricular pressures that are lower than those that the left ventricle normally encounters. As such, the right ... During the end-systolic volume phase of the cardiac cycle, the Gaussian curvature and the mean curvature of right ventricular ...
... is a measure of left ventricular diastolic function, and has been shown to be relatively independent of left ventricular ... If there is impaired relaxation (Diastolic dysfunction), the e' velocity decreases. After the early relaxation, the ventricular ... Likewise, peak ticuspid annular systolic velocity has become a measure of the right ventricular systolic function As the ... This has become a major echocardiographic tool for assessment of both systolic and diastolic ventricular function. However, as ...
Diastolic dysfunction is also associated with AF, which increases left atrial pressure, left atrial volume, size, and left ... left ventricular size and function, peak right ventricular pressure (pulmonary hypertension), presence of left atrial thrombus ... According to the CHARGE Consortium, both systolic and diastolic blood pressure are predictors of the risk of AF. Systolic blood ... Lower heart rates may be recommended in those with left ventricular hypertrophy or reduced left ventricular function.[110] Rate ...
... and bringing the LV end-systolic volume back to baseline. Diastolic dysfunction is associated with a reduced compliance, or ... The mechanism is of functional importance because it serves to adapt left ventricular output to right ventricular output. If ... Premature ventricular contraction causes early emptying of the left ventricle (LV) into the aorta. Since the next ventricular ... Therefore the force (pressure) generated by the cardiac muscle fibres is related to the end-diastolic volume of the left and ...
... many will have a reduced left ventricular ejection fraction that indicates a combination of systolic and diastolic dysfunction ... Diastolic dysfunction must be differentiated from diastolic heart failure. Diastolic dysfunction can be found in elderly and ... When the left ventricular diastolic pressure is elevated, venous pressure in lungs must also become elevated too: left ... Any condition or process that leads to stiffening of the left ventricle can lead to diastolic dysfunction. Other causes of left ...
One of the earliest signs is mild left ventricular diastolic dysfunction with little effect on ventricular filling. Also, the ... After the development of systolic dysfunction, left ventricular dilation and symptomatic heart failure, the jugular venous ... 2004). "Evidence of left ventricular dysfunction in asymptomatic elderly patients with non-insulin-dependent diabetes mellitus ... of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction ...
... leaving an abnormally elevated volume of blood in the left ventricle. In diastolic dysfunction, the end-diastolic ventricular ... Diastolic dysfunction can be caused by processes similar to those that cause systolic dysfunction, particularly causes that ... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... ventricular end-diastolic pressure and volumes increase. This is transmitted to the atrium. On the left side of the heart, the ...
Left ventricular size, thickness, systolic function, and diastolic function Right ventricular size and systolic function Aortic ... However, the angle of the probe with these valves can lead to under-appreciation of valve dysfunction. The parasternal long ... Left ventricular size and wall thickness Left atrial linear dimension (as opposed to area) Left ventricular outflow tract ... In this view, the mitral valve, aortic valve, right ventricular outflow tract, base of the left ventricle, and the left atrium ...
Cardiac chamber catheterization assists in assessing the severity of regurgitation and any left ventricular dysfunction. The ... While diastolic blood pressure is diminished and the pulse pressure widens, systolic blood pressure generally remains normal or ... 0.3 cm2 Increased left ventricular size Chest X-ray can assist in making the diagnosis, showing left ventricular hypertrophy ... This relaxation of the left ventricle (early ventricular diastole) causes a fall in its pressure. When the pressure in the left ...
Major clinical correlates include systolic and diastolic dysfunction, associated at times with systemic embolic events. Non- ... "Left Ventriuclar noncompaction" (PDF). Orphanet. Retrieved June 14, 2007. "Left Ventricular Non-compaction". Baylor College of ... Jenni R, Oechslin E (2005). "Non-compaction of the Left Ventricular Myocardium - From Clinical Observation to the Discovery of ... "Non-compaction of the Left Ventricular Myocardium - From Clinical Observation to the Discovery of a New Disease". Touch ...
Cardiovascular system damage can include myocardial ischemia/infarction, acute left ventricular dysfunction, acute pulmonary ... It is estimated that for every 20 mm Hg systolic or 10 mm Hg diastolic increase in blood pressures above 115/75 mm Hg, the ... As the left ventricle becomes unable to compensate for an acute rise in systemic vascular resistance, left ventricular failure ... with hypertensive crises often have chest pain as a result of this mismatch and may suffer from left ventricular dysfunction. ...
Previously normal left ventricular ejection fraction or left ventricular systolic dysfunction out of proportion to a patient's ... studies indicate that patients with TIC may have a smaller left ventricular end-diastolic dimension compared to patients with ... the need to continue these agents after treatment of the tacharrhythmia and resolution of left ventricular systolic dysfunction ... is made after excluding other causes of cardiomyopathy and observing resolution of the left ventricular systolic dysfunction ...
In the case of diastolic dysfunction without systolic dysfunction, fluid resuscitation may, in fact, improve circulation by ... In certain circumstances, a left ventricular assist device (LVAD) may be necessary. Once the person is stabilized, attention ... Difficulty breathing, a cardinal symptom of left ventricular failure, may manifest with progressively increasing severity as ... If it ruptures on the intraventricular septum, it can create a ventricular septal defect. Other causes of cardiac tamponade may ...
Both valsalva maneuver and standing decrease venous return to the heart thereby decreasing left ventricular diastolic filling ( ... A murmur that lasts throughout the whole of systole is known as a holo-systolic murmur. A murmur that is mid to late systolic, ... and other signs suggestive of autonomic nervous system dysfunction (dysautonomia). Mitral valve prolapse is frequently ... Symptomatic people, those with evidence of diminished left ventricular function, or those with left ventricular dilatation need ...
... diastolic dysfunction), where a decrease in Left Ventricular (LV) filling corresponds to an increasingly reduced stroke volume ... This results in a reduction in left ventricular stroke volume, and will be noted as a reduction in systolic blood pressure in ... Lower left atrial compliance reduces the left atrium venous return and as a consequence causes a reduction in left ventricular ... the diastolic dysfunction is also proportionally greater, so the systolic pressure drops >10 mmHg. This mechanism is also ...
Cite journal requires ,journal= (help) Pollak, A; Falk, R H (1993-08-01). "Left ventricular systolic dysfunction precipitated ... Patients will demonstrate normal systolic function, diastolic dysfunction, and a restrictive filling pattern. 2-dimensional and ... Normal systolic function, Poor diastolic function, typically Grade III - IV Diastolic heart failure. Those afflicted with RCM ... In time, restrictive cardiomyopathy patients develop diastolic dysfunction and eventually heart failure.[citation needed] ...
DA is the diastolic filling period. Blood flows from the left atrium to the left ventricle. Atrial contraction completes ... Systolic dysfunction Cardwell, D. S. L. (1971). From Watt to Clausius: The Rise of Thermodynamics in the Early Industrial Age. ... At point D pressure falls below the atrial pressure and the mitral valve opens, initiating ventricular filling. ... Example PV loop diagram of a mouse left ventricle Human heart A is the end-diastolic point; this is the point where contraction ...
Point:Left ventricular volume during diastasis is the physiological in vivo equilibrium volume and is related to diastolic ... model-based derivation with in-vivo validation in control and diastolic dysfunction subjects. J. Appl. Physiology, 2006;101: 92 ... Manson McGuire A, Hagley MT, Hall AF, Kovács SJ, Jr.: Relationship of the fourth heart sound to atrial systolic transmitral ... The Effects of Caloric Restriction- and Exercise-Induced Weight Loss on Left Ventricular Diastolic Function. American Journal ...
... the swelling of lung tissue due to left ventricular failure an inability of the left ventricle of the heart to adequately pump ... Severely elevated blood pressure (equal to or greater than a systolic 180 or diastolic of 110-sometimes termed malignant or ... This may include hypertensive encephalopathy, caused by brain swelling and dysfunction, and characterized by headaches and an ... direct damage to one or more organs as a result of severely elevated blood pressure greater than 180 systolic or 120 diastolic ...
... because of severe diastolic dysfunction of the left ventricle. They may also develop a left atrial thrombus that embolizes, ... ECHO assesses cardiac ventricular size, wall thickness, systolic and diastolic function, and outflow obstruction. Thus, ECHO ... Since the pacemaker activates the interventricular septum before the left ventricular free wall, the gradient across the left ... "The effect of ramipril on left ventricular mass, myocardial fibrosis, diastolic function, and plasma neurohormones in Maine ...
PAP is significantly increased for each step-up in diastolic dysfunction grade. ... LV diastolic dysfunction is associated with an increase in PAP in subjects with normal systolic function. ... Pulmonary artery pressure and diastolic dysfunction in normal left ventricular systolic function Int J Cardiol. 2008 Jul 4;127( ... Conclusions: LV diastolic dysfunction is associated with an increase in PAP in subjects with normal systolic function. PAP is ...
Left Physiological aspects Left heart ventricle Natriuretic peptides Health aspects Measurement ... as predictor of left ventricular systolic and diastolic dysfunction in patients with chronic heart failure.(B-type natriuretic ... systolic+and...-a0305560819. *APA style: NT-proBNP levels, as predictor of left ventricular systolic and diastolic dysfunction ... MLA style: "NT-proBNP levels, as predictor of left ventricular systolic and diastolic dysfunction in patients with chronic ...
... left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVMI, left ventricular mass index; LAD ... LV: left ventricular; LVDD: left ventricular diastolic dysfunction; HFpEF: heart failure with preserved ejection fraction; LS: ... Myocardial systolic and diastolic consequences of left ventricular mechanical dyssynchrony in heart failure with normal left ... Left ventricular diastolic and systolic dyssynchrony and dysfunction in heart failure with preserved ejection fraction and a ...
2001) Striking effect of left ventricular systolic performance on propagation velocity of left ventricular early diastolic ... left ventricular ejection fraction. MI. myocardial infarction. PSF. preserved systolic function. SDF. systolic dysfunction. Sm ... Lack of Inertia Force of Late Systolic Aortic Flow Is a Cause of Left Ventricular Isolated Diastolic Dysfunction in Patients ... Lack of Inertia Force of Late Systolic Aortic Flow Is a Cause of Left Ventricular Isolated Diastolic Dysfunction in Patients ...
... and prognosis of left ventricular (LV) systolic and diast ... Based on Left Ventricular Systolic or Diastolic Dysfunction. ... Diagnosis and Treatment of Heart Failure Based on Left Ventricular Systolic or Diastolic Dysfunction. JAMA. 1994;271(16):1276- ... and prognosis of left ventricular (LV) systolic and diastolic dysfunction. These studies also indicate that medical therapy can ... Annual mortality is higher in those with systolic dysfunction than in those with diastolic dysfunction, but within each of ...
Potential confounding variables evaluated: hemoglobin, LDH, arginine-ornithine ratio, age, heart rate, systolic and diastolic ... Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking ... Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking ... Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking ...
Patients with left ventricular systolic dysfunction (according to qualitative "eyeball" assessment, see below), valvular heart ... of our patients with heart failure and preserved left ventricular systolic function could be said to have diastolic dysfunction ... By using the E:A ratio, 67% (74% men and 64% women) had "diastolic dysfunction." Left ventricular hypertrophy was detected in ... Body mass index-Of the 109 patients with suspected heart failure in the absence of left ventricular systolic dysfunction, ...
left ventricular systolic dysfunction (ejection fraction ,45%). *stable clinical conditions in the previous three months ... In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is ... Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients. This study has been completed. ... We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of ...
... diastolic dysfunction has been reported as a cardiovascular effect of hyperthyroidism, and is also supposed to be a cause of ... Dysfunction Cause Exertional Dyspnea in Newly Diagnosed Hyperthyroid Patients with Preserved Left Ventricular Systolic Function ... Diastolic function of the patients at rest was assessed using these parameters as follows: left atrium volume index, tricuspid ... Abstract Background: diastolic dysfunction has been reported as a cardiovascular effect of hyperthyroidism, and is also ...
Answers from specialists on diastolic dysfunction. First: it depends on the causes -- for example, obesity and elevated BP can ... Mild left ventricular systolic dysfunctionLeft ventricular ejection fraction 40 % with global left ventricular hypokinesis, ... Echocardiogram: evidence of left ventricular diastolic relaxation abnormality. Mildly decreased systolic function. Wall motion ... Dilated left heart and reduced lv function. Generalized lv hypokinesia diastolic dysfunction, what to do? ...
Endothelial dysfunction, cardiomyocyte dysfunction, and cardiomyocyte injury. Systolic and diastolic left ventricular ... Left ventricular ejection fraction-based taxonomy of HF and its implications have been criticized.[4-6] Here, we advocate the ... Left Ventricular Ejection Fraction-based Taxonomy of HF is Imprecise and Incomplete ... Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to ...
Ventricular Dysfunction, Left/classification , Ventricular Dysfunction, Left/epidemiology , Ventricular Dysfunction, Left/ ... Prevalence of Left Ventricular Diastolic Dysfunction in Patients with Normal Systolic Function and its Relation with Other Risk ... Prevalence of Left Ventricular Diastolic Dysfunction in Patients with Normal Systolic Func ... Patients of isolated diastolic dysfunction were identified and the degree of diastolic dysfunction was correlated with ...
PubMed journal article Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fractio ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. SN ... In HF with an ejection fraction ,/=0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. ... has been classified as systolic and diastolic based on the left ventricular ejection fraction. We hypothesized that left ...
Left ventricular diastolic dysfunction in pts with hypertension and preserved systolic function. Mayo Clin Proc 200;75:148-55. ... Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med 2004;55:373-94. ... Left ventricular diastolic dysfunction in elderly hypertensives; results of the APROS-diadys study. J Hyperten 2007;25:2158-67. ... Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey. Heart 2006;92:1259-64. ...
Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis. J Am ... Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey. Heart 2006;92:1259-64. ... Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic ... Background Preclinical diastolic dysfunction (PDD) has been defined as subjects with normal systolic function, diastolic ...
Left ventricular systolic dysfunction, i.e., left ventricular ejection fraction (LVEF) , 40% or left ventricular shortening ... Left ventricular diastolic dysfunction, i.e., PCWP , 15 mmHg at rest or with exercise, acute volume loading or pharmacologic ... mean left atrial pressure (mLAP), or left ventricular end diastolic pressure (LVEDP) ≤ 15 mmHg and a PVR ≥ 240 dynes.sec/cm-5 ... Systemic hypertension defined as systolic blood pressure (SBP) , 160 mmHg and/or diastolic blood pressure (DBP) , 100 mmHg ...
One problem two issues! Left ventricular systolic and diastolic dysfunction in aortic stenosis. ...
No single test could diagnose systolic dysfunction. Combined use of heart rate, diastolic blood pressure, and N-terminal atrial ... 0.45 and their predictive value for left ventricular systolic dysfunction.. Results: 15 patients (12%) had left ventricular ... left ventricular systolic dysfunction where previous screening brought the unconditional probability of systolic dysfunction to ... The prevalence of left ventricular systolic dysfunction was 12%(nine men and six women). Table 2 describes these 15 patients. ...
... systolic dysfunction, or diastolic dysfunction. Heart failure with normal left ventricular systolic function must be ... diastolic dysfunction often is present in patients who also have left ventricular systolic dysfunction, and most patients with ... Diastolic dysfunction. Normal myocardial contractility, left ventricular volume, and ejection fraction; impaired myocardial ... Diastolic dysfunction. Normal myocardial contractility, left ventricular volume, and ejection fraction; impaired myocardial ...
found that treatment with resveratrol improved left ventricular systolic and diastolic function. Additionally, resveratrol ... improved flow-mediated dilation (FMD), which when impaired causes endothelial dysfunction. The treatment also inhibited ... Langcake, P. W. V. M. The relationship of resveratrol production to infection of grapevine leaves by Botrytis cinerea. Vitis 18 ... showed that daily resveratrol treatment for 3 months decreased HbA1c levels, systolic blood pressure, total cholesterol, and ...
Pulmonary hypertension due to left heart diseases. *Left ventricular systolic dysfunction. *Left ventricular diastolic ... Unfortunately, left ventricular end-diastolic pressure was concomitantly assessment in only a minority of patients [35]. This ... in patients with echocardiographic signs of systolic and/or diastolic dysfunction and when PAWP measurement is unreliable [1]. ... et al.Characterization of static and dynamic left ventricular diastolic function in patients with heart failure with a ...
... with a hypertensive response to exercise have impaired systolic function without diastolic dysfunction or left ventricular ... Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic ... Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. ... Doppler tissue imaging reveals systolic dysfunction in patients with hypertension and apparent "isolated" diastolic dysfunction ...
... as well as the time constant of left ventricular pressure decay, tau (tau), as an index of relaxation. The slope of the end- ... SHR have increased systolic performance accompanied by delayed relaxation and increased diastolic stiffness. ... conductance catheter system to evaluate systolic and diastolic function in vivo at different preloads, including preload ... diastolic pressure-volume relation (EDPVR) and the ex vivo PV relation, both indexes of stiffness, were also calculated for ...
Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction. An 8-year follow ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ... Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction ...
Assessment of left ventricular systolic and diastolic dysfunction.- Right ventricular dysfunction in heart failure.- The role ... Assessment of left ventricular contractile reserve in heart failure.- Role of cardiac magnetic resonance imaging in heart ...
Systolic, diastolic and subclinical left ventricular dysfunction are often present in sarcoidosis [20]. In a retrospective ... suggesting left ventricular disease as a cause of PH [7]. Left ventricular dysfunction might be due to myocardial involvement ... Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in ... Right ventricle/left ventricle basal diameter ratio ,1.0. Flattening of the interventricular septum (left ventricular ...
18986398 - Assessment of systolic and diastolic left ventricular and left atrial function using ve.... 19558518 - Tei index ... 8608458 - Diastolic dysfunction.. 19763068 - Echocardiography in the assessment of heart failure.. ... end systolic volume decrease of ≥ 15% after CRT.. RESULTS: Right ventricular (RV) pacing-induced left bundle branch block (LBBB ... we analyzed 27 ECG and echocardiographic variables to predict a positive response to CRT defined as a left ventricular (LV) ...
Asymptomatic left ventricular systolic dysfunction, Diastolic failure. *Acute myocardial infarction. *Hypertension. *Secondary ... Right Ventricular Function Working Group on Aorta and Peripheral Vascular Diseases Working Group on Myocardial Function Working ...
... diastolic dysfunction, left ventricular diastolic dysfunction, diastolic heart failure, impaired diastolic filling; systolic ... diastolic dysfunction, left ventricular diastolic dysfunction, diastolic heart failure, impaired diastolic filling; systolic ... systolic and diastolic blood pressure, left ventricular and diastoic pressure, left ventricular dP/dt, body weight, and heart ... women with a systolic blood pressure less than 140 mm Hg such as less than 130 mm Hg or 120 mm Hg or a diastolic blood pressure ...
ASSESSMENT OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; PART 5. ASSESSMENT OF DIASTOLIC FUNCTION / DYSFUNCTION; PART 6. ISCHAEMIC ... and easily accessible manual on using echocardiography for sonographers and trainee cardiologists that should never be left ...
  • Plasma BNP levels also increase with decreasing physiological functional capacities, as measured by left ventricular ejection fraction (LVEF) or exercise-based evaluations [9]. (thefreelibrary.com)
  • Conventional echocardiography predictors of poor outcome, such as left ventricular (LV) ejection fraction (EF) and restrictive filling pattern have recently been supplemented by tissue Doppler imaging (TDI). (thefreelibrary.com)
  • In patients with heart failure (HF) symptoms, echocardiography often reveals a low left ventricular ejection fraction (LVEF). (thefreelibrary.com)
  • Liu S, Guan Z, Jin X, Meng P, Wang Y, Zheng X, Jia D, Ma C, Yang J. Left ventricular diastolic and systolic dyssynchrony and dysfunction in heart failure with preserved ejection fraction and a narrow QRS complex. (medsci.org)
  • Seventy-eighty patients with a narrow QRS complex including 47 with HFpEF, 31 with heart failure with reduced ejection fraction (HFrEF) patients, and 29 with asymptomatic left ventricular diastolic dysfunction (LVDD) were recruited. (medsci.org)
  • However, little evidence exists to demonstrate that cardiac-resynchronization therapy (CRT) benefits patients with HFpEF, despite a study showing a clinical and structural improvement in patients with a mean left ejection fraction (LVEF) of 43±7% after CRT [ 7 ]. (medsci.org)
  • In patients with coronary artery disease who have preserved LV systolic function (ejection fraction ≥50%), an absence of inertia force of late systolic aortic flow has a significant relation with impaired LV relaxation and LV early diastolic filling. (onlinejacc.org)
  • Methods We evaluated LV apical wall motion and obtained left ventricular ejection fraction (LVEF) by left ventriculography in 101 patients who underwent cardiac catheterization to assess CAD. (onlinejacc.org)
  • More than 40% of patients suffering from congestive heart failure have preserved left ventricular ejection fraction (LVEF) ( 1-3 ). (onlinejacc.org)
  • Those with LV dysfunction and a normal LV ejection fraction (ie, diastolic dysfunction) also benefit from medical therapy. (jamanetwork.com)
  • Abstract Background: diastolic dysfunction has been reported as a cardiovascular effect of hyperthyroidism, and is also supposed to be a cause of heart failure manifestations in the patients with preserved ejection fraction (EF). (authorea.com)
  • Randomized clinical trials initially used heart failure (HF) patients with low left ventricular ejection fraction (LVEF) to select study populations with high risk to enhance statistical power. (medscape.com)
  • [ 1 ] These trials were initially designed predominantly on logistics more than on pathophysiological considerations, aiming to increase the statistical power and to limit trial costs, by enrolling patients with poor prognosis based on low left ventricular (LV) ejection fraction (LVEF). (medscape.com)
  • Left ventricular ejection fraction-based taxonomy of HF and its implications have been criticized. (medscape.com)
  • 0.05) related to ejection fraction 0.45 and their predictive value for left ventricular systolic dysfunction. (bmj.com)
  • Mild left ventricular systolic dysfunctionLeft ventricular ejection fraction 40 % with global left ventricular hypokinesis,Myxomatousmorphology mv? (healthtap.com)
  • Heart failure (HF) has been classified as systolic and diastolic based on the left ventricular ejection fraction. (unboundmedicine.com)
  • We hypothesized that left ventricular diastolic dysfunction is an important element of HF regardless of ejection fraction. (unboundmedicine.com)
  • 0.001) but not with ejection fraction or end-diastolic volume index (EDVI). (unboundmedicine.com)
  • Thus, regardless of ejection fraction, patients who have HF also have diastolic dysfunction. (unboundmedicine.com)
  • Diastolic dysfunction is a better predictor of B-type natriuretic peptide levels and mortality than ejection fraction or left ventricular EDVI. (unboundmedicine.com)
  • LV ejection fraction (EF) and end-diastolic diameter (EDD) were recorded from echocardiography. (ahajournals.org)
  • Diastolic dysfunction is frequently accompanied by impaired LV systolic function despite a normal ejection fraction. (ahajournals.org)
  • 2 Although it is important for nurses to have knowledge of these 7 key indicators and the rational behind the medical treatment of this population set, this article focuses on the pharmacological treatments used for symptoms of HF and reduced left ventricular ejection fraction (LVEF). (nursingcenter.com)
  • RESULTS The presence of type 2 diabetes was associated with more severe LV systolic and diastolic dysfunction 8 years later: LV ejection fraction was 2.98% (95% CI 0.46-5.51) lower, and left atrial (LA) volume index, LV mass index, and tissue Doppler-derived E/e′ were 3.71 mL/m 2 (1.20-6.22), 5.86 g/m 2.7 (2.94-8.78), and 1.64 units (0.95-2.33) higher, respectively. (diabetesjournals.org)
  • The most frequent comorbid conditions of heart failure with normal LV ejection fraction (HFNEF) (mainly characterized by LV diastolic dysfunction) are hypertension, type 2 diabetes, and obesity ( 1 ). (diabetesjournals.org)
  • RESULTS: Right ventricular (RV) pacing-induced left bundle branch block (LBBB), time difference between LV ejection measured by tissue Doppler and pulsed wave Doppler (T(TDI-PW)), and wall motion score index (WMSI) were significantly associated with positive CRT response by multivariate regression. (biomedsearch.com)
  • With the addition of echocardiographic variables, lower ejection fraction was associated with male gender, black race, prior myocardial infarction, and higher ventricular mass and lower relative wall thickness, pulse pressure, and body mass index. (ahajournals.org)
  • heart failure due to left ventricular dysfunction and heart failure with normal ejection fraction depending on whether the ability of the left ventricle to contract is affected, or the heart's ability to relax. (wikipedia.org)
  • Left ventricular (LV) dysfunction is classified as impaired ventricular contraction and ejection (systolic dysfunction) and impaired relaxation and ventricular filling (diastolic dysfunction). (medscape.com)
  • echocardiogram and other imaging techniques: cardiac size, ventricular systolic and diastolic function, ejection fraction, etc. (brainscape.com)
  • Patients with low ejection fractions (EF) may not be symptomatic when compared to patients with preserved left ventricular function. (ispub.com)
  • A transthoracic echocardiograph showed a reduced left ventricular ejection fraction and severe right ventricular systolic dysfunction. (jaoa.org)
  • Patients with either symptomatic or asymptomatic LV dysfunction as defined by echocardiographic ejection fraction (mcmaster.ca)
  • Leonardi and colleagues compared echocardiographic indices of diastolic function to MRI T2* estimations of myocardial iron concentration and ejection fractions in patients with transfusion-dependent thalassemia. (onlinejacc.org)
  • Diastolic function parameters correlated poorly with ejection fraction and myocardial T2*, and were thus not well-suited for cardiac risk stratification. (onlinejacc.org)
  • As diastolic dysfunction may precede systolic dysfunction, we sought to directly compare more readily available echocardiographic indices of diastolic function to myocardial T2* and ejection fraction (EF). (onlinejacc.org)
  • MPI was abnormally high in the presence of LBBB despite having a normal left ventricular ejection fraction. (scirp.org)
  • BACKGROUND: Preventive implantation of an implantable cardioverter defibrillator (ICD) early after myocardial infarction failed to demonstrate a survival benefit in patients with depressed left ventricular ejection fraction (LVEF). (smw.ch)
  • Current guidelines for the prevention of sudden cardiac death (SCD) after myocardial infarction recommend the implantation of an implantable cardioverter defibrillator (ICD) in patients with a left ventricular ejection fraction (LVEF) ≤35% (for patients in NYHA class II or III) or ≤30% (NYHA class I) not earlier than 40 days after myocardial infarction [1]. (smw.ch)
  • Patients with asymptomatic severe AS and an LV ejection fraction of 50% or higher are recognized as Stage C1 AS and those with LV systolic dysfunction are recognized as Stage C2 AS. (acc.org)
  • The diagnosis of heart failure with preserved ejection fraction (HFpEF) due to diastolic dysfunction is difficult, especially in patients with multiple co-morbidities. (dundee.ac.uk)
  • Hyperglycemia and nocturnal systolic blood pressure are associatedwith left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients. (ebscohost.com)
  • The possibility that both left ventricular hypertrophy and renal failure could have been caused by a storage disease or by amyloidosis, was discussed. (escardio.org)
  • Left ventricular hypertrophy (LVH) is an adaptive response of the heart to sustained work overload. (scielo.br)
  • Data in the literature 1 have shown that the load conditions and neurohumoral systems, among which the renin-angiotensin-aldosterone system (RAAS) stands out, modulate the characteristics of left ventricular hypertrophy that develop in the presence of chronic pressure overload. (scielo.br)
  • Angiotensin-converting enzyme inhibitors have also been proved to decrease left ventricular hypertrophy in human beings 7 and in experimental animals with chronic pressure overload 8,9 . (scielo.br)
  • The favorable effects of ACEI on survival and regression of left ventricular hypertrophy in heart failure and arterial hypertension are frequently attributed to interference with the RAAS, resulting in a reduction in blood pressure and peripheral vascular resistance with a consequent reduction in cardiac overload 10 . (scielo.br)
  • Although the efficacy of the ACEI in prolonging survival, delaying the development of ventricular dysfunction, and reversing cardiac hypertrophy is widely recognized, it has been difficult to dissociate the hemodynamic effects of those agents on systemic blood pressure from the effects of the myocardial tissue ACE blockade. (scielo.br)
  • Therefore, the use of ACEI in arterial hypertension, acute myocardial infarction, and cardiomyopathy is clearly justified, because those drugs block RAAS activity, reduce cardiac load, and reverse left ventricular hypertrophy. (scielo.br)
  • As aldosterone has been implicated in the genesis of myocardial fibrosis, hypertrophy, and dysfunction, we sought to determine the effects of aldosterone antagonism on myocardial function in hypertensive patients with suspected diastolic heart failure by using sensitive quantitative echocardiographic techniques in a randomized, double-blinded, placebo-controlled study. (ahajournals.org)
  • 5,6 Experimental studies implicate aldosterone in the genesis of myocardial fibrosis, hypertrophy, and dysfunction, and these processes may be preventable, 7,8 and possibly even reversible, 9 with aldosterone blockade. (ahajournals.org)
  • Activation of PKC and MAP kinase has been implicated in stimulating cardiac growth ( 11 - 14 ), and homozygous transgenic expression of an activated mutant human Ras in mice causes left ventricular hypertrophy with normal systolic function ( 15 ). (pnas.org)
  • EKG/ECG shows left ventricular hypertrophy with strain pattern. (medhelp.org)
  • Certain conditions such as ischemia, left ventricular hypertrophy, hypertension, and aortic stenosis predispose to DD. (jabfm.org)
  • These compensatory mechanisms include neurohormonal activation, increased contractility, vasoconstriction, and ventricular hypertrophy and remodeling. (medscape.com)
  • Left ventricular hypertrophy without any other structural heart disease was present in 28% of the patients. (scirp.org)
  • This study examined the association of metabolic syndrome with left ventricular hypertrophy, diastolic dysfunction and systolic dysfunction. (scribd.com)
  • From 56 individuals who meet the metabolic syndrome in 12 patients (21.4%) had ventricular hypertrophy and 45 patients (80.35%) had diastolic dysfunction and 10 cases (17.85%) had impaired systolic performance. (scribd.com)
  • This study did not confirm the association of metabolic syndrome with ventricular hypertrophy. (scribd.com)
  • Key Words: Metabolic Syndrome, Ventricular Hypertrophy, Echocardiography. (scribd.com)
  • Metabolic syndrome includes a variety of cause cardiac diastolic and systolic dysfunction metabolic disorders that expose the patient with the even in individuals that are not suffering from left risk of coronary cardiovascular diseases (CVD) and ventricular hypertrophy. (scribd.com)
  • hypotheses of the increased cardiac events in the The present study aims determining the prevalence metabolic syndrome suggests that the disorder rate of left ventricular hypertrophy and cardiac created in the function of the left ventricle brings dysfunction according to the echocardiographic about an increased risk of cardiovascular disease in indices in metabolic syndrome patients referring to the patients suffering from this syndrome. (scribd.com)
  • They have recently described for the first time how BNP could be used in primary prevention to detect patients with silent asymptomatic heart disease such as left ventricular hypertrophy and silent coronary artery disease. (dundee.ac.uk)
  • Chronic hypertension often leads to left ventricular hypertrophy, which may be associated with diastolic or, in late stages, systolic dysfunction. (health.am)
  • We analyzed retrospectively 477 consecutive echocardiographic studies that were performed in the Meir Medical Center echocardiography laboratory in subjects with normal LV systolic function and correlated the state of diastolic function (normal, impaired relaxation, pseudo normal and restrictive pattern) to the magnitude of pulmonary artery pressure (PAP) assessed by echocardiography. (nih.gov)
  • in this regard, echocardiography may be useful in confirming diastolic dysfunction [13]. (thefreelibrary.com)
  • Systolic LV longitudinal strain (LS), systolic longitudinal strain rate (LSrS), early diastolic longitudinal strain rate (LSrE), and late diastolic longitudinal strain rate (LSrA) were measured using speckle tracking echocardiography. (medsci.org)
  • Using color Doppler echocardiography, we measured the propagation velocity of LV early diastolic filling flow (Vp). (onlinejacc.org)
  • Methods: for evaluation of diastolic function in hyperthyroid patients and also diastolic Function during performing exercise stress echocardiography, we conducted this study on 26 newly diagnosed hyperthyroid patients compared to 26 healthy subjects as control group. (authorea.com)
  • and during exercise stress echocardiography, we judged diastolic response by measuring E/e' ratio and TR velocity at the peak of stress in terms of the American Society of Echocardiography guideline. (authorea.com)
  • Interestingly, no patients developed diastolic dysfunction during exercise stress echocardiography. (authorea.com)
  • We studied consecutive patients who were referred with a diagnosis of suspected heart failure by general practitioners to our direct access transthoracic echocardiography service and were found to have preserved left ventricular systolic function. (bmj.com)
  • To assess the probability of left ventricular systolic dysfunction without echocardiography in patients from general practice. (bmj.com)
  • Cross sectional study using multivariate regression models to examine the relation between clinical variables and left ventricular systolic dysfunction as determined by echocardiography. (bmj.com)
  • Patients can be identified for echocardiography on the basis of an abnormal electrocardiogram combined with increased natriuretic peptide concentration or a heart rate greater than diastolic blood pressure, or both. (bmj.com)
  • 1 - 5 About 3% of the adult population have systolic dysfunction, 6 - 8 but half of them are asymptomatic and can be identified only by objective methods, usually echocardiography. (bmj.com)
  • The purpose of the study was to examine how primary care doctors might identify patients at increased risk of systolic dysfunction in order to decide who to refer for echocardiography. (bmj.com)
  • The results of echocardiography and catheter‑based measurements revealed that GLN treatment attenuated cardiac dysfunction. (spandidos-publications.com)
  • Linked to EACVI recommendations and the EACVI Core Curriculum The EACVI Echo Handbook is an essential and easily accessible manual on using echocardiography for sonographers and trainee cardiologists that should never be left behind when performing an echocardiogram. (whsmith.co.uk)
  • According to hospital records, in initial bed-side echocardiography the maximal left ventricular wall thickness measured up to 18 mm. (escardio.org)
  • Echocardiography showed thickened left ventricular walls, systolic and diastolic dysfunction. (escardio.org)
  • Echocardiography showed normal left and right ventricular systolic function but revealed diastolic dysfunction of the left ventricle. (wiley.com)
  • In the study,1012 primary care patients with hypertension and/or diabetes without signs or symptoms of heart failure were screened for asymptomatic left ventricular dysfunction (ALVD), using measurements of NT-pro-BNP and echocardiography. (scienceblog.com)
  • The full study is "The Role of N-Terminal PRO-Brain Natriuretic Peptide and Echocardiography for Screening Asymptomatic Left Ventricular Dysfunction in a Population at High Risk for Heart Failure: The PROBE-HF Study" by Irene Betti, Gabriele Castelli, Alessandro Barchielli, Cinzia Beligni, Vittorio Boscherini, Leonardo De Luca, Gianni Messeri, Mihai Gheorghiade, Alan Maisel, and Alfredo Zuppiroli. (scienceblog.com)
  • Post-systolic shortening during dobutamine stress echocardiography predicts cardiac survival in patients with severe left ventricular dysfunction. (nih.gov)
  • BACKGROUND Atrioventricular plane displacement (AVPD) study by M-mode echocardiography can supply useful clinical information about left ventricular (LV) long-axis function. (semanticscholar.org)
  • Conventional echocardiography and VVI- based strain imaging were performed to analyze subclinical LV systolic function. (bmj.com)
  • Myocardial perfusion by myocardial contrast echocardiography and endothelial dysfunction in obstructive sleep apnea. (birmingham.ac.uk)
  • Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats. (semanticscholar.org)
  • Strain rate (SR) imaging and cyclic variation (CV) of integrated backscatter (IB) are sensitive echocardiographic techniques that provide quantitative assessment of regional myocardial systolic function. (ahajournals.org)
  • In the Echocardiographic Study of Hispanics/Latinos (ECHO-SOL), researchers used ultrasound images of the heart to identify cardiac dysfunction in adults, age 45-74, living in the Bronx, Chicago, Miami and San Diego. (eurekalert.org)
  • MATERIAL AND METHODS: In 100 consecutive patients who received CRT, we analyzed 27 ECG and echocardiographic variables to predict a positive response to CRT defined as a left ventricular (LV) end systolic volume decrease of ≥ 15% after CRT. (biomedsearch.com)
  • 10 With the development of echocardiographic methods that provide a high yield of quantitative LV measurements, it has become possible to determine the prevalence and correlates of LV systolic dysfunction in population-based samples of hypertensive patients. (ahajournals.org)
  • Accordingly, the present study was undertaken to assess the prevalence and clinical and echocardiographic correlates of mild and severe LV systolic dysfunction in hypertensive black and white women and men participating in the Hypertension Genetic Epidemiology Network (HyperGEN) Study. (ahajournals.org)
  • We evaluated, whether auto-servo ventilation (ASV, BiPAP ASV, Philips Respironics) improves echocardiographic measures of diastolic function in patients with systolic HF and SDB. (ersjournals.com)
  • To assess the association of the risk of OSA, evaluated by the Berlin Questionnaire (BQ), and echocardiographic (ECHO) parameters related to diastolic dysfunction in individuals without HF assisted in primary care. (scielo.br)
  • Patients undergoing transcatheter aortic valve replacement (TAVR) often have spontaneous echocardiographic contrast (SEC) observed in the left atrium (LA). Mid-term prognosis of patients with SEC following TAVR is not well studied. (invasivecardiology.com)
  • Objectives We sought to evaluate whether echocardiographic diastolic function indices correlate with myocardial iron and systolic function in patients with transfusion-dependent thalassemia (TDT) who are at risk for cardiomyopathy. (onlinejacc.org)
  • Echocardiographic measurements of transmitral flow velocities (E, A), tissue Doppler velocities (E′), and left ventricular volume and EF were compared with MRI measurements of myocardial T2*, ventricular volume, and EF. (onlinejacc.org)
  • Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. (bmj.com)
  • Novel echocardiographic techniques may provide additional data for detecting early deterioration in ventricular systolic function in patients with systemic inflammatory diseases like TA and SLE. (bmj.com)
  • Patients with LVEF ≥50% (preserved systolic function [PSF], n = 83) were divided into 2 subgroups: patients with inertia force (n = 53) and without inertia force (n = 30). (onlinejacc.org)
  • In patients with severe systolic LV dysfunction, higher LV myocardial scar burden, detected on DHE-MRI is associated with worse survival, despite similar LVEF, LVEDD, and prevalence of CAD. (ahajournals.org)
  • Methods: 32 patients with stable systolic HF and concomitant diastolic dysfunction (age 66±9y, LVEF 30±7%, NYHA class II 72%) and SDB (AHI 48±19/h, 53% OSA) were randomized to either ASV (n=19) or optimal medical treatment alone (control, n=13). (ersjournals.com)
  • HF syndrome, however, may also occur in patients with preserved LVEF but with abnormalities in left ventricular diastolic function. (jabfm.org)
  • Studies indicate that 30% to 55% of patients with CHF have preserved systolic function, defined as LVEF of 45% or greater. (jabfm.org)
  • Impaired diastolic filling of left ventricle may be the important cause of symptoms ranging from mild to severe form of dyspnea with overt features of pulmonary edema which may be wrongly imparted to systolic failure. (bvsalud.org)
  • Amyloidosis presents with ventricle and valvular thickening, biatrial enlargement, [4] restrictive filling pattern, with normal to mildly reduced systolic function [5] and decreased diastolic filling . (wikipedia.org)
  • In LVSD, the left ventricle, the heart's largest chamber, does not push blood out to the body as forcefully as it should. (eurekalert.org)
  • In LVDD, the left ventricle is too stiff when relaxed between beats to gather enough blood in its chamber. (eurekalert.org)
  • The pathophysiological changes related to OSA can directly affect the diastolic function of the left ventricle. (scielo.br)
  • Mouse left ventricle imaged with 4D Mode from a parasternal long axis view. (visualsonics.com)
  • Mitral flow visualized from an apical view of the mouse left ventricle to assess diastolic function. (visualsonics.com)
  • B-Mode ultrasound with myocardial oxygen saturation acquired using photoacoustics ( PA EKV Mode ), from a parasternal long axis view of the mouse left ventricle. (visualsonics.com)
  • Catheterization of the right side of the heart with contrast ventriculogram revealed a nearly obliterated ( image B , dotted line) right ventricle with interatrial passage of contrast and subsequent left ventricular opacification ( image B , arrows). (jaoa.org)
  • Structure of the left ventricle was impaired at baseline in this group to the same degree as in a group of 40 otherwise healthy essential hypertension patients without sleep apnea and when compared with 40 healthy patients without either condition. (medpagetoday.com)
  • Our analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. (nih.gov)
  • Thus, the MRI analyses of diabetic left ventricle suggest impairment of diastolic and systolic hemodynamics in this rat model of diabetic cardiomyopathy. (nih.gov)
  • Because the descriptive term congestive heart failure does not provide for these important distinctions, a new classification of LV dysfunction has been developed in which patients with LV dysfunction are categorized on the basis of normal or abnormal systolic function. (jamanetwork.com)
  • Given that not all patients are volume overloaded at the time of diagnosis (diastolic dysfunction), the term "heart failure" is now preferred over "congestive heart failure. (slideserve.com)
  • To assess the effects of lisinopril (L) on mortality (M) rate and congestive heart failure (CHF), and the characteristics of geometrical myocardial remodeling and left ventricular function in rats with supravalvular aortic stenosis (SAS). (scielo.br)
  • Selected beta-blockers are indicated for the chronic management of patients with congestive heart failure symptoms and reduced ventricular systolic function due to ischemic heart disease, nonischemic cardiomyopathy, and regurgitant valvular lesions. (clinicaladvisor.com)
  • An elevated left atrial pressure with left ventricular (LV) diastolic dysfunction causes symptoms of heart failure at rest and during exercise ( 4-7 ). (onlinejacc.org)
  • 109 of 159 participants had suspected heart failure in the absence of left ventricular systolic dysfunction, valvular heart disease, or atrial fibrillation. (bmj.com)
  • Patients with left ventricular systolic dysfunction (according to qualitative "eyeball" assessment, see below), valvular heart disease, and atrial fibrillation were not studied further. (bmj.com)
  • The LAVi is 14 m1/m2 consistent with normal left atrial pressures. (healingwell.com)
  • The spironolactone group also exhibited reduction in posterior wall thickness ( P =0.04) and a trend to reduced left atrial area ( P =0.09). (ahajournals.org)
  • Data from the MONICA (Monitoring of Trends and Determinations in Cardiovascular Disease) registry have shown that hypertension and obesity-both associated with type 2 diabetes and arterial stiffness-independently predicted left atrial (LA) enlargement, a sensitive indicator of an elevated LV preload ( 3 ). (diabetesjournals.org)
  • Natriuretic peptides counteract vasoconstriction and are released upon atrial or ventricular stretch. (medscape.com)
  • Transfusion-associated circulatory overload (TACO) is acute pulmonary edema associated with left atrial hypertension or volume overload occurring within 6 hours following a blood transfusion. (dovepress.com)
  • TACO, likely the most common of these, is defined as symptoms and signs of acute pulmonary edema associated with left atrial hypertension or volume overload occurring within 6 hours of blood transfusion. (dovepress.com)
  • 7 In severe AS, all (reservoir, conduit, and active) of left atrial (LA) function was impaired. (invasivecardiology.com)
  • Are Measures of Left Ventricular Longitudinal Shortening Affected by Left Atrial Enlargement? (semanticscholar.org)
  • Those changes in left atrial volume may have an impact on outcomes too, because an enlarged left atrium independently raises risk of atrial fibrillation, heart failure, and other cardiovascular events, Lip's group noted. (medpagetoday.com)
  • Left ventricular fibrosis in atrial fibrillation. (birmingham.ac.uk)
  • The aim of this study was to evaluate the correlation between diastolic dysfunction and pulmonary arterial hypertension in patients with normal left ventricular (LV) wall motion. (nih.gov)
  • Hypertension, diabetes, dyslipidemia and obesity have significant association with diastolic dysfunction. (bvsalud.org)
  • What's systolic hypertension? (healthtap.com)
  • This study suggests that the evaluation of NT-proBNP in asymptomatic patients with type 2 diabetes or hypertension may lead to very early exclusion of LV dysfunction. (scienceblog.com)
  • Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling. (nih.gov)
  • Note that this study indicates that moderate-to-severe sleep apnea can cause structural and functional changes in left ventricular function comparable to that seen in hypertension and, further, these abnormalities significantly improve following CPAP therapy. (medpagetoday.com)
  • Left ventricular mass index, too, was higher at 124 g/m 2 in the apnea group and 121 in the hypertension group compared with 102 in the controls ( P =0.009). (medpagetoday.com)
  • Nearly every measure of left ventricular diastolic function came out significantly worse for the apnea and hypertension groups than for healthy controls. (medpagetoday.com)
  • I am particularly interested in the role of the sympathetic nervous system, endothelium, macro- and microvascular dysfunction in hypertension. (birmingham.ac.uk)
  • Vascular ventricular coupling in patients with malignant phase hypertension: the West Birmingham malignant hypertension project. (birmingham.ac.uk)
  • Persistent macrovascular and microvascular dysfunction in patients with malignant hypertension. (birmingham.ac.uk)
  • Shantsila A, Shantsila E. Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension? (birmingham.ac.uk)
  • NT-proBNP levels, as predictor of left ventricular systolic and diastolic dysfunction in patients with chronic heart failure. (thefreelibrary.com)
  • Chronic heart failure (CHF) is currently recognized as a clinical syndrome occurring not only as a result of rnechanical dysfunction of the ventricles, but also due to complex molecular, endocrine, neuroendocrine, and inflammatory changes [3] Neurohormonal activation plays a fundamental role in the onset and progression of heart failure and the use of biochemical markers as prognostic indicators in heart failure have expanded in the last decade. (thefreelibrary.com)
  • Plasma BNP levels provide clinically useful information concerning the diagnosis and management of left ventricular dysfunction and heart failure, which complements other diagnostic testing procedures (e.g., electrocardiograms, chest x-rays, and echocardiograms) [6,7]. (thefreelibrary.com)
  • Left ventricular (LV) isolated diastolic dysfunction is a well-recognized cause of heart failure. (onlinejacc.org)
  • Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? (bmj.com)
  • To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with "diastolic heart failure. (bmj.com)
  • For most patients with a diagnosis of heart failure but preserved left ventricular systolic function there is an alternative explanation for their symptoms-for example, obesity, lung disease, and myocardial ischaemia-and the diagnosis of diastolic heart failure is rarely needed. (bmj.com)
  • With the recent wide availability of non-invasive assessments of left ventricular function it has become apparent that many patients diagnosed as having heart failure have preserved left ventricular systolic function. (bmj.com)
  • 1 2 It has been proposed that these patients have abnormalities of ventricular filling in diastole, and the term "diastolic heart failure" has been coined. (bmj.com)
  • 1 - 3 It does, however, seem likely that given the non-specificity of the symptoms and signs used to diagnose heart failure at least some of these patients may not have abnormalities of diastolic ventricular function but other causes of their symptoms altogether. (bmj.com)
  • Patients -We studied patients with preserved left ventricular systolic function who were referred with suspected heart failure to an outpatient based direct access cardiography service. (bmj.com)
  • is resting supine heart rate greater than the simultaneous diastolic blood pressure? (bmj.com)
  • In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. (clinicaltrials.gov)
  • Diastolic dysfunction, which means impaired relaxing or filling ability of the heart, was seen on your study. (healthtap.com)
  • Dilated left heart and reduced lv function. (healthtap.com)
  • Dependent edema and pulmonary rales are of limited value in diagnosing heart failure resulting from left ventricular dysfunction. (aafp.org)
  • Role of right ventricular systolic function on long-term outcome in patients with newly diagnosed systolic heart failure," Circulation Journal , vol. 75, no. 9, pp. 2176-2181, 2011. (hindawi.com)
  • Distinguish left heart failure from right heart failure in terms of etiology and physiologic effects. (powershow.com)
  • Describe how right heart failure may result from left heart failure. (powershow.com)
  • New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. (semanticscholar.org)
  • New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. (semanticscholar.org)
  • Contribution of ventricular remodeling to pathogenesis of heart failure in rats. (semanticscholar.org)
  • Diastolic heart failure. (semanticscholar.org)
  • Clinical studies 2,3 have shown that angiotensin-converting enzyme inhibitors (ACEI) improve the survival of patients with heart failure, delay heart decompensation in patients with asymptomatic left ventricular dysfunction, and attenuate the progression of left ventricular dilation and dysfunction after myocardial infarction. (scielo.br)
  • Amyloid deposition in the heart can cause both diastolic and systolic heart failure . (wikipedia.org)
  • An understanding of the process of left ventricular (LV) remodeling has led to greater knowledge of the pathophysiology of heart failure syndrome. (biomedsearch.com)
  • The studies cited suggest that the post-myocardial infarction process is related to and associated with long-term progression of LV dysfunction, heart failure symptoms, and mortality. (biomedsearch.com)
  • Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and contractile dysfunction. (medscape.com)
  • Heart failure develops when the heart, via an abnormality of cardiac function (detectable or not), fails to pump blood at a rate commensurate with the requirements of the metabolizing tissues or is able to do so only with an elevated diastolic filling pressure. (medscape.com)
  • Indeed, improved outcomes with spironolactone in systolic heart failure have been linked to the antifibrotic effects of the drug. (ahajournals.org)
  • 13,14 Effective therapies for hypertensive heart disease might therefore be expected to result in improvement of both systolic and diastolic function, depending on the sensitivity and accuracy of the particular measurement techniques used. (ahajournals.org)
  • 15,16 These techniques are able to detect subtle myocardial dysfunction in early hypertensive heart disease 17 and other preclinical cardiomyopathies, 18,19 and therefore have the potential to detect changes in myocardial function that might occur in response to specific interventions. (ahajournals.org)
  • This article provides an overview of heart failure (HF) and pharmacological treatment of systolic left ventricular dysfunction. (nursingcenter.com)
  • This work is aimed, during fluid-replacement and oxygen therapy, to determine the physiological interface of ventricular and vascular mechanical properties, which result in the transfer of blood from the heart to appropriate circulatory beds. (diva-portal.org)
  • DALLAS, April 5, 2016 -- Hispanics/Latinos have higher rates of cardiac dysfunction but are rarely aware they have the heart-pumping problem that can lead to heart failure, according to new research in the American Heart Association's journal Circulation: Heart Failure . (eurekalert.org)
  • Cardiac dysfunction is particularly serious because it can develop into heart failure, a chronic disease in which the heart pumps less blood than the body needs to remain healthy. (eurekalert.org)
  • Researchers noted that these risk factors, along with heart attack, were the same risk factors for progression of cardiac dysfunction to heart failure. (eurekalert.org)
  • Rodriguez said that because Hispanics/Latinos have been overlooked in previous studies, there are no reliable estimates of how many with cardiac dysfunction will develop heart failure. (eurekalert.org)
  • Moreover, a recent review of medical records revealed that even after exclusion of heart failure patients, 23% of individuals with type 2 diabetes had LV diastolic dysfunction ( 2 ). (diabetesjournals.org)
  • ACE inhibitors, angiotensin receptor blockers, diuretics, beta blockers, coronary reperfusion therapy) for recent myocardial infarction complicated by left ventricular dysfunction and clinical heart failure showed that adding the aldosterone receptor antagonist, eplere-none, reduced mortality compared with adding placebo. (aafp.org)
  • One systematic review showed that implantable cardiac defibrillators reduced mortality in persons with heart failure who have experienced a near-fatal ventricular arrhythmia or are at high risk of sudden death. (aafp.org)
  • 2,3,6,7 However, the proportion of cases of clinical CHF that are due to left ventricular (LV) systolic dysfunction compared with LV diastolic dysfunction, valvular heart disease, or other causes is not well established. (ahajournals.org)
  • [6] In those with heart failure due to left ventricular dysfunction, angiotensin converting enzyme inhibitors or angiotensin receptor blockers along with beta blockers are recommended. (wikipedia.org)
  • [18] A ventricular assist device or occasionally a heart transplant may be recommended in those with severe disease despite all other measures. (wikipedia.org)
  • Here we show that a point mutation in a mammalian-specific ribosomal protein causes mitochondrial dysfunction, heart abnormalities and progressive liver disease. (prolekare.cz)
  • Background: Systolic heart failure (HF) is frequently accompanied by diastolic dysfunction and sleep-disordered breathing (SDB). (ersjournals.com)
  • Previously the subject of much debate, there is now consensus that diastolic heart failure (DHF) represents a distinct form of heart failure. (jabfm.org)
  • Indeed, there is evidence that, among elderly persons, DHF is more common than systolic heart failure (SHF). (jabfm.org)
  • Differences exist in prognosis and treatment between diastolic and systolic heart failure. (jabfm.org)
  • This article reviews diastolic heart failure with emphasis on evidence-based management, aimed at primary care physicians who routinely provide care to patients with DHF. (jabfm.org)
  • Such a heart failure (HF) syndrome (ie, diastolic heart failure [DHF]) is now widely accepted among cardiologists as representing a distinct form of HF. (jabfm.org)
  • Patients with heart failure often have coexisting renal dysfunction. (diabetesjournals.org)
  • 334 The ECG in diagnosis of heart failure (HF) due to left ventricular systolic dysfunction (LVSD) � Is advice from guidelines flawed? (ebscohost.com)
  • 345 Prognostic value of the 12-lead-ECG in patients with systolic heart failure a subgroup analysis of Va1HeFT. (ebscohost.com)
  • An abstract of the study "Prognostic value of the 12-1ead-ECG in patients with systolic heart failure a subgroup analysis of VaIHeFT," by M. Hofmann and colleagues is presented. (ebscohost.com)
  • 356 Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function. (ebscohost.com)
  • An abstract of the study "Clinical characteristics of patients referred with suspected heart failure and preserved left ventricular systolic function," by C. Constantin and colleagues is presented. (ebscohost.com)
  • 112 Heart failure with preserved and depressed left ventricular systolic function: features and prognosis in a multicenter registry of 4720 patients. (ebscohost.com)
  • An abstract of the study "Heart failure with preserved and depressed left ventrricular systolic function: features and prognosis in a multicenter registry of 4720 patients," by J. C. Castillo and colleagues is presented. (ebscohost.com)
  • 275 Does systolic function determine the prognosis of hospitalized patients due to worsening heart failure? (ebscohost.com)
  • 53 Cardiac contractility modulation electrical signals improve LV diastolic function in dogs with heart failure. (ebscohost.com)
  • An abstract of the study "Cardiac Contractility Modulation Electrical Signals Improve LV Diastolic Function in Dogs With Heart Failure," by Y. Mika and colleagues is presented. (ebscohost.com)
  • 509 Therapy with Vagus nerve electrical stimulation combined with beta-blockade improves left ventricular systolic function in dogs with heart failure beyond that seen with beta-blockade alone. (ebscohost.com)
  • Diagnosis of chronic systolic and diastolic biventricular heart failure secondary to Löffler endocarditis and endomyocardial fibrosis was made. (jaoa.org)
  • One hundred sixteen patients with LV dysfunction caused by ischemic heart disease or idiopathic dilated cardiomyopathy were studied. (mcmaster.ca)
  • 3) treatment for end stage heart failure with ventricular assist devices (VAD). (oslo-universitetssykehus.no)
  • n=13, age 73±6 years) underwent simultaneous right- and left-heart catheterisation within 12 h of cardiorespiratory polygraphy recording. (ersjournals.com)
  • However, MPI provides the information about combined systolic and diastolic functions and is reported to be investigated from the point of analysis of its relation to heart diseases. (scirp.org)
  • 3. Heart failure symptoms with preserved left ventricular systolic function (primary diastolic dysfunction). (clinicaladvisor.com)
  • Reduced heart rate resulting from beta blockade may increase diastolic filling times, which can lower diastolic filling pressure and alleviate pulmonary congestion. (clinicaladvisor.com)
  • Several studies have suggested that obstructive sleep apnea contributes to the development of left ventricular systolic and diastolic dysfunction and, possibly, heart failure. (medpagetoday.com)
  • This may imply that obstructive sleep apnea could be crucial in development of left ventricular diastolic dysfunction, which may lead to heart failure and increased mortality if left untreated," they concluded. (medpagetoday.com)
  • The team's work on BNP as a biomarker of left ventricular wall stress showed for the first time that BNP was elevated in patients with the other form of heart failure (isolated diastolic dysfunction). (dundee.ac.uk)
  • the research on brain/B-type natriuretic peptide (BNP) has helped diagnose both types of heart failure (systolic and diastolic heart failure) and to identify high-risk aortic stenosis patients for surgery. (dundee.ac.uk)
  • BNP testing is now recommended in Guidelines as a screening test for patients with suspected heart failure (Class I recommendation) and in the current European Society of Cardiology consensus statement for diagnosis of diastolic heart failure. (dundee.ac.uk)
  • This restriction in ventricular motion results in a decreased ability for the heart to pump efficiently, leading to the various symptoms associated with cardiac amyloidosis. (wikipedia.org)
  • What does pulmonary artery systolic pressure of 24 mmHg indicate? (healthtap.com)
  • Other factors that may contribute include peripheral vascular dysfunction, skeletal muscle physiology, pulmonary dynamics, and neurohormonal and reflex autonomic activity1. (ispub.com)
  • A 35-cm ultrasound-accelerated thrombolysis catheter was placed in the left pulmonary artery. (jaoa.org)
  • Abnormal left ventricular systolic or diastolic function suggests cardiogenic pulmonary edema rather than ARDS. (bmj.com)
  • In addition the left ventricular contractility was diminished (Fig. 2). (escardio.org)
  • The negative effect of beta-blockers on ventricular contractility may alleviate outflow obstruction and may improve diastolic performance (see below). (clinicaladvisor.com)
  • Conclusions Ventricular long axis functions are important markers of myocardial contractility. (bmj.com)
  • Applying this strategy, only transient early central hypovolemia was recorded, while dimensional preload, global left ventricular systolic function and oxygen delivery or consumption remained within normal ranges during the first 36 hours after accident. (diva-portal.org)
  • Prediction of global left ventricular function after bypass surgery in patients with severe left ventricular dysfunction. (nih.gov)
  • Despite the substantial differences in the EF, Both groups have reductions in exercise tolerance, neurohumoral activation, and abnormal left ventricular (LV) filling dynamics and impaired relaxation and have similar clinical symptoms and signs. (thefreelibrary.com)
  • Quantitative MCE shows that patients with diabetes but no evidence of obstructive coronary artery disease have impaired MBF reserve, but abnormal transmural flow and subclinical longitudinal myocardial dysfunction are not related. (bmj.com)
  • Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. (bioportfolio.com)
  • 3,4 Hypertensive patients with abnormal LV filling patterns suggestive of diastolic dysfunction may be asymptomatic but often report exertional dyspnea. (ahajournals.org)
  • 10 In addition, aldosterone is associated with abnormal vascular function, 11 which may be related to the development of diastolic HF. (ahajournals.org)
  • The patients with high risk for OSA present significantly abnormal diastolic function parameters. (scielo.br)
  • Impairment in left ventricular (LV) systolic function might be a major concern in TA due to chronic inflammation. (bmj.com)
  • Resting peak systolic strain rate (SR) and peak systolic strain (ε) were calculated in the same 10 myocardial segments. (bmj.com)
  • Long-axis strain rate (SR), peak systolic strain, and cyclic variation of integrated backscatter (CVIB) were averaged from 6 walls in 3 standard apical views. (ahajournals.org)
  • Values for SR, peak systolic strain, and CVIB were similar between groups at baseline and remained unchanged with placebo. (ahajournals.org)
  • Longitudinal peak systolic strain (13.20±3.5% to 20.97±4.5%, p=0.0001) and strain rate (0.23±0.18 1/s to 4.92±0.55 1/s, p=0.0001) of the LV were significantly impaired in patients with TA, compared to controls, demonstrating subclinical ventricular systolic dysfunction. (bmj.com)
  • Therefore, targeting to improve diastolic and systolic function instead of managing systolic dyssynchrony might be of great importance in the treatment of HFpEF. (medsci.org)
  • Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. (semanticscholar.org)
  • Relative systolic dysfunction in female spontaneously hypertensive rat myocardium. (semanticscholar.org)
  • In a population-based sample of hypertensive patients, left ventricular systolic dysfunction was related to male gender, black race, diabetes, and elevated uric acid levels, as well as higher ventricular mass and lower relative wall thickness. (ahajournals.org)
  • Impaired systolic dysfunction of left ventricular longitudinal fibers: a sign of early hypertensive cardiomyopathy. (semanticscholar.org)
  • Increased short-term blood pressure variability is associated with early left ventricular systolic dysfunction in newly diagnosed untreated hypertensive patients. (semanticscholar.org)
  • Moderate-to-severe obstructive sleep apnea was associated with significantly larger left ventricles and poorer filling and emptying parameters compared with controls, similar to what was seen in hypertensive adults in a study by Gregory Y.H. Lip, MD, of the University of Birmingham, England, and colleagues. (medpagetoday.com)
  • Severe burns thereby cause myocardial stiffness and systolic regional dysfunction, which may not be prevented only by central normovolemia and adequate oxygenation. (diva-portal.org)
  • OBJECTIVE To investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up. (diabetesjournals.org)
  • More arterial stiffness (measured as a lower distensibility) was associated with LV diastolic dysfunction 8 years later: LA volume index, LV mass index, and E/e′ at follow-up were higher. (diabetesjournals.org)
  • Associations of type 2 diabetes and arterial stiffness with markers of LV diastolic dysfunction were largely independent of each other. (diabetesjournals.org)
  • Therefore, type 2 diabetes and arterial stiffness may relate to LV diastolic dysfunction through different pathways. (diabetesjournals.org)
  • Metabolic disturbances and arterial stiffness are both recognized contributors to left ventricular (LV) stiffness and LV systolic and diastolic dysfunction. (diabetesjournals.org)
  • Arterial stiffness is hypothesized to lead to increased arterial wave reflections, which in turn lead to an increased cardiac afterload and myocardial oxygen demand and simultaneously to a decreasing diastolic coronary perfusion pressure ( 6 ). (diabetesjournals.org)
  • 2 ,3 Impaired ventricular relaxation and increased ventricular stiffness are mechanisms by which these conditions lead to DD and subsequently to DHF. (jabfm.org)
  • Trans V gradient 8mmHg LV Dimensionally Normal preserved Systolic Doppler Mild LV Diastolic dysfunction. (healthtap.com)
  • Diastolic Function: Doppler derived data suggests mild left ventricular diastolic dysfunction. (healingwell.com)
  • Utility of B-natriuretic peptide in detecting diastolic dysfunction: comparison with Doppler velocity recordings. (semanticscholar.org)
  • Colour Doppler shows reversal of E/A ratio indicating diastolic dysfunction with mild sclerosis of aortic valve and apical cardiomyopathy. (medhelp.org)
  • The right ventricular cavity was nearly obliterated by a homogeneous mass, and spectral Doppler ultrasonography demonstrated diminished antegrade systolic flow across the pulmonic valve. (jaoa.org)
  • however its association with diastolic dysfunction in subjects with normal LV systolic function has not been thoroughly studied. (nih.gov)
  • Objectives We investigated whether a lack of inertia force of late systolic aortic flow and/or apical asynergy provoke early diastolic dysfunction in patients with coronary artery disease (CAD). (onlinejacc.org)
  • Prolonged left ventricular dysfunction occurs in patients with coronary artery disease after both dobutamine and exercise induced myocardial ischaemia. (nih.gov)
  • We also computed the LV relaxation time constant (Tp) and the inertia force of late systolic aortic flow from the LV pressure (P)-first derivative of left ventricular pressure (dP/dt) relation. (onlinejacc.org)
  • At baseline, 24 (75%) patients had impaired left ventricular relaxation, and 8 (25%) had a pseudonormalized filling pattern. (ersjournals.com)
  • At the 12-weeks control visit, diastolic function as assessed by the isovolumetric relaxation time (IVRT, -10.3±26.1 vs. 9.3±49.1, P=0.5) and deceleration time (DT, -43.9±88.8 vs. 12.4±68.8, P=0.4) did not significantly improve after ASV treatment. (ersjournals.com)
  • The time constant of left ventricular relaxation: extrication from load dependence and overestimation of functional abnormality. (nih.gov)
  • 0.50 is associated with mild systolic dysfunction and an increased ratio of left ventricular mass to EDVI. (unboundmedicine.com)
  • Diastolic dysfunction was found in 368 subjects (36%) and was categorized as mild in 327 and moderate-severe in 41. (scienceblog.com)
  • Left ventricular diastolic dysfunction (LVDD) has long been considered as the main cause of HFpEF, however, large previous clinical trials failed to improve the prognosis of HFpEF by restoring LV diastolic function[ 3 , 4 , 5 ]. (medsci.org)
  • Data from large and small clinical trials reflect major differences in the pathophysiology, treatment, and prognosis of left ventricular (LV) systolic and diastolic dysfunction. (jamanetwork.com)
  • Patients of isolated diastolic dysfunction were identified and the degree of diastolic dysfunction was correlated with functional class (NYHA grade) of the patients as well as various risk factors. (bvsalud.org)
  • 3,4 Alterations in hemodynamics and neurohumoral balance are the major culprits in the development of ventricular dysfunction. (nursingcenter.com)
  • In most patients with preserved LV systolic function, a lack of inertia force is associated with LV apical wall motion abnormality. (onlinejacc.org)
  • HF with preserved EF (HF p EF), also referred to as diastolic dysfunction , is defined as clinical signs of HF with an EF of 50% or greater. (medscape.com)
  • Clinical outcomes in adults with aortic valve stenosis (AS) are predicted by symptom status, valve anatomy, hemodynamics and left ventricular (LV) systolic function. (acc.org)
  • Professor Allan Struthers (Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, Dundee) and his team showed that plasma levels of brain/B-type natriuretic peptide (BNP) could be used in clinical practice to detect left ventricular systolic dysfunction. (dundee.ac.uk)
  • Left Ventricular measurements taken from a B-Mode parasternal long axis image. (visualsonics.com)
  • Hemodynamic measurements demonstrated atrialization of the right ventricular pressure waveform. (jaoa.org)
  • Measurements of LV end-diastolic volume, end-systolic volume were made using the biplane area-length method. (mcmaster.ca)
  • However, several studies did not find an association between kidney dysfunction and cardiac output or other hemodynamic parameters. (wikipedia.org)
  • Prevalence of Left Ventricular Diastolic Dysfunction in Patients with Normal Systolic Function and its Relation with Other Risk Factors from Eastern India. (bvsalud.org)
  • To study prevalence and severity of diastolic dysfunction and its relation with various risk factors. (bvsalud.org)
  • The prevalence was significantly related to three questions: does the electrocardiogram have Q waves, left bundle branch block, or ST-T segment changes? (bmj.com)
  • 8,9 Furthermore, few data are available on the combined prevalence of symptomatic and asymptomatic LV systolic dysfunction in population samples, 6 especially of high-risk groups such as blacks. (ahajournals.org)
  • This study shows that the prevalence of metabolic syndrome in referred patients to Imam-Ali hospital, Zabol, relatively is high and there is relationship between the metabolic syndrome and ventricular diastolic. (scribd.com)
  • 0.40, systolic dysfunction and left ventricular dilation accompany diastolic dysfunction. (unboundmedicine.com)
  • That reduction in left ventricular thickness "may have long-term prognostic implications," the group noted. (medpagetoday.com)
  • Identification and treatment of patients with left ventricular systolic dysfunction improves survival and reduces morbidity. (bmj.com)
  • How exactly CPAP improves systolic function isn't clear, but it may involve reducing blood pressure, hypoxia, rapid intrathoracic pressure changes, and secondary hemodynamic disturbances, the researchers suggested. (medpagetoday.com)
  • Post ischemic diastolic function: pursuing a cautious path from laboratory to operating room. (nih.gov)
  • Objectives We sought to determine to what extent systemic arterial compliance (SAC) might impact on afterload and left ventricular (LV) function in patients with aortic stenosis (AS). (onlinejacc.org)
  • In patients with aortic stenosis (AS), the occurrence of left ventricular (LV) dysfunction, symptoms, and adverse outcomes does not always correlate with the classical markers of hemodynamic severity (i.e., valve effective orifice area[EOA] and transvalvular pressure gradients). (onlinejacc.org)
  • demonstrated the value of BNP as a biomarker for left ventricular systolic dysfunction, isolated diastolic dysfunction and for aortic stenosis. (dundee.ac.uk)
  • EKG changes may be present, showing low voltage and conduction abnormalities like atrioventricular block or sinus node dysfunction. (wikipedia.org)
  • Stress MCE and SRI were performed in 48 patients (22 with type II diabetes mellitus (DM) and 26 controls), all with normal left ventricular systolic function and no obstructive coronary disease by quantitative coronary angiography. (bmj.com)
  • No left venticular obstructive pathology. (medhelp.org)
  • Left ventricular systolic and diastolic function in obstructive sleep apnea: impact of continuous positive airway pressure therapy. (birmingham.ac.uk)
  • PAP is significantly increased for each step-up in diastolic dysfunction grade. (nih.gov)
  • We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. (clinicaltrials.gov)
  • Likewise, the proportion of patients whose diastolic dysfunction improved was non-significantly higher in the ASV than in the control group, respectively (37% vs. 15%, P=0.2). (ersjournals.com)
  • Experimental studies 4-6 have shown that ACEIs attenuate ventricular remodeling, improve survival, and delay the progression of left ventricular dysfunction in rats with myocardial infarction and hamsters with cardiomyopathy. (scielo.br)
  • Reversal of ischaemic systolic and diastolic left ventricular dysfunction by successful coronary angioplasty in patients with non-Q wave anterior myocardial infarction. (nih.gov)
  • Objectives We aimed to evaluate subclinical LV systolic dysfunction in patients with TA, without any cardiovascular disease and to compare them with patients with systemic lupus erythematosus (SLE), by using a novel strain imaging method, "velocity vector imaging" (VVI). (bmj.com)
  • Metabolic syndrome can high BMI higher than 25 is the prognostic of the increase the incidence rate of cardiovascular diastolic dysfunction, and it is the main prognostic diseases including coronary artery diseases, sudden factor of systolic and diastolic dysfunction [11]. (scribd.com)