Period of contraction of the HEART, especially of the HEART VENTRICLES.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Contractile activity of the MYOCARDIUM.
The valve between the left atrium and left ventricle of the heart.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The graphic recording of chest wall movement due to cardiac impulses.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
The hollow, muscular organ that maintains the circulation of the blood.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The hemodynamic and electrophysiological action of the LEFT ATRIUM.
Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.
Timing the acquisition of imaging data to specific points in the cardiac cycle to minimize image blurring and other motion artifacts.
Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)
Act of listening for sounds within the heart.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
The circulation of blood through the CORONARY VESSELS of the HEART.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
The sounds heard over the cardiac region produced by the functioning of the heart. There are four distinct sounds: the first occurs at the beginning of SYSTOLE and is heard as a "lubb" sound; the second is produced by the closing of the AORTIC VALVE and PULMONARY VALVE and is heard as a "dupp" sound; the third is produced by vibrations of the ventricular walls when suddenly distended by the rush of blood from the HEART ATRIA; and the fourth is produced by atrial contraction and ventricular filling.
The hemodynamic and electrophysiological action of the HEART ATRIA.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
A twisting deformation of a solid body about an axis. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
The chambers of the heart, to which the BLOOD returns from the circulation.
A fetal blood vessel connecting the pulmonary artery with the descending aorta.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Resistance and recovery from distortion of shape.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
Motion pictures of the passage of contrast medium through blood vessels.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Examinations used to diagnose and treat heart conditions.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
A vasodilator that is administered by inhalation. It is also used recreationally due to its supposed ability to induce euphoria and act as an aphrodisiac.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The flow of BLOOD through or around an organ or region of the body.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
Changes in the observed frequency of waves (as sound, light, or radio waves) due to the relative motion of source and observer. The effect was named for the 19th century Austrian physicist Johann Christian Doppler.
Elements of limited time intervals, contributing to particular results or situations.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The circulation of the BLOOD through the LUNGS.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The veins and arteries of the HEART.
The innermost layer of the heart, comprised of endothelial cells.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
The main trunk of the systemic arteries.
A technique for assisting the circulation by decreasing the afterload of the left ventricle and augmenting the diastolic pressure. It may be achieved by intra-aortic balloon, or by implanting a special pumping device in the chest, or externally by applying a negative pressure to the lower extremities during cardiac systole.
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Treatment process involving the injection of fluid into an organ or tissue.
A computer based method of simulating or analyzing the behavior of structures or components.
The vessels carrying blood away from the heart.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Substances used to allow enhanced visualization of tissues.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Narrowing or constriction of a coronary artery.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Computer-based representation of physical systems and phenomena such as chemical processes.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The measurement of an organ in volume, mass, or heaviness.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Altered vascular reactivity following partial nephrectomy in the rat: a possible mechanism of the blood-pressure-lowering effect of heparin. (1/3311)

BACKGROUND: This study was designed to assess whether the antihypertensive effect of heparin in rats after renal mass reduction (RMR) is related to changes in nitric oxide activity, and to study in vitro the altered behaviour of resistance-sized arteries induced by chronic administration of heparin. METHODS: Male Wistar rats were assigned to one of two experimental protocols. In the first protocol, RMR rats received heparin (250 units/day s.c.) and tail systolic blood pressure (SBP) was measured weekly for 4 weeks. In a subgroup, urinary nitrate excretion (UNO3) and in vitro vascular reactivity of isolated perfused mesenteric arterial beds were measured 2 weeks after RMR. The second protocol assessed whether inhibition of NO synthesis with L-NAME (70 mg/l added to the drinking water) prevents the blood-pressure-lowering effect of heparin. RESULTS: In untreated RMR rats SBP increased from 111+/-3 mmHg to 127+/-5 mmHg at 2 weeks and 139+/-5 mmHg at 4 weeks. In contrast, in RMR rats treated with heparin, SBP was 114 +/-3 mmHg at 2 weeks and 115+/-4 mmHg at 4 weeks (P<0.05 for both). Treatment with L-NAME increased SBP both in untreated and heparin-treated RMR groups. Two weeks after nephrectomy daily urinary nitrate increased significantly more in RMR rats treated with heparin than in untreated RMR rats (22+/-2 vs 14.2+/-2.3 micromol/day, P<0.05). In vitro studies performed at 2 weeks showed that vessels of untreated RMR rats had a blunted vasodilator response to acetylcholine that was restored to levels similar to that of controls in the heparin-treated group. CONCLUSIONS: These results suggest that, in rats after renal ablation, heparin may exert its antihypertensive effect, at least in part, by affecting the altered behaviour of resistance vessels during the development phase of hypertension. Increased NO production may contribute to this effect.  (+info)

Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy. (2/3311)

BACKGROUND: Hypertension is a recognized marker of poor prognosis in IgA nephropathy. METHODS: The present study investigated the prevalence of white-coat hypertension, the diurnal rhythm of blood pressure (BP), the effectiveness of antihypertensive drug therapy, and the effect of the above on the progression of the kidney disease in IgA nephropathy. One hundred twenty-six IgA nephropathy patients were selected consecutively for 24-h ambulatory blood pressure monitoring (ABPM). Fifty-five patients were normotensive and 71 were treated hypertensives. Their antihypertensive drugs were angiotensin-converting enzyme inhibitors (ACEI) alone or in combination with calcium-channel blockers (CCB). RESULTS: The mean night-time BP of normotensives (108+/-9/67+/-6 mmHg) was significantly lower than their day-time BP (125+/-8/82+/-7 mmHg, P<0.05). There was no significant difference between the mean day-time and night-time BP in hypertensive patients (125+/-9/82+/-7 mmHg vs 128+/-10/85+/-9 mmHg). The circadian variation of BP was preserved ('dippers') in 82% of the normotensive and 7% of the hypertensive patients (P<0.001). There were 10 'white-coat hypertensives' among the patients classified as normotensives with ABPM (mean office blood pressure 149+/-7/96+/-8 mmHg, 24-h blood pressure 127+/-6/83+/-5 mmHg, P<0.05) and 14 among treated hypertensives (mean office BP 152+/-8/98+/-6 mmHg, 24-h BP 130+/-4/85+/-8 mmHg, P<0.05). There was no difference in mean day-time BP among normotensive and treated hypertensive patients (125+/-8/81+/-5 mmHg vs 128+/-10/85+/-9 mmHg). Hypertensives had significantly higher night-time BP (125+/-9/85+/-9 mmHg) than normotensives (108+/-9/67+/-6 mmHg, P<0.001). There was no difference in serum creatinine levels among the different groups at the time of the ABPM. However, thirty-six+/-4.1 months after the ABPM, hypertensive patients (n=52) had higher serum creatinine levels (124+/-32 micromol/l) than at the time of the ABPM (101+/-28 micromol/l). The serum creatinine of normotensive patients (n=43) did not change during the follow-up period. 'Non-dipper' normotensives (n=10) had significantly higher serum creatinine levels at the end of the follow-up period than at its beginning (106+/-17 micromol/l vs 89+/-18 micromol/l, P<0.05). There was no increase in serum creatinine of 'dipper' normotensives. The mean serum creatinine of 'white-coat hypertensives' was significantly higher at the end of the study period than at its beginning. CONCLUSIONS: There is no diurnal blood pressure variation in most of the hypertensive IgA nephropathy patients. ACEI and CCB treatment have better effect on day-time than night-time hypertension. The lack of the circadian rhythm and 'white-coat hypertension' seems to accelerate the progression of IgA nephropathy.  (+info)

Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. (3/3311)

BACKGROUND: Recent reports suggest that calcium-channel blockers may be harmful in patients with diabetes and hypertension. We previously reported that antihypertensive treatment with the calcium-channel blocker nitrendipine reduced the risk of cardiovascular events. In this post hoc analysis, we compared the outcome of treatment with nitrendipine in diabetic and nondiabetic patients. METHODS: After stratification according to center, sex, and presence or absence of previous cardiovascular complications, 4695 patients (age, > or =60 years) with systolic blood pressure of 160 to 219 mm Hg and diastolic pressure below 95 mm Hg were randomly assigned to receive active treatment or placebo. Active treatment consisted of nitrendipine (10 to 40 mg per day) with the possible addition or substitution of enalapril (5 to 20 mg per day) or hydrochlorothiazide (12.5 to 25 mg per day) or both, titrated to reduce the systolic blood pressure by at least 20 mm Hg and to less than 150 mm Hg. In the control group, matching placebo tablets were administered similarly. RESULTS: At randomization, 492 patients (10.5 percent) had diabetes. After a median follow-up of two years, the systolic and diastolic blood pressures in the placebo and active-treatment groups differed by 8.6 and 3.9 mm Hg, respectively, among the diabetic patients. Among the 4203 patients without diabetes, systolic and diastolic pressures differed by 10.3 and 4.5 mm Hg, respectively, in the two groups. After adjustment for possible confounders, active treatment was found to have reduced overall mortality by 55 percent (from 45.1 deaths per 1000 patients to 26.4 deaths per 1000 patients), mortality from cardiovascular disease by 76 percent, all cardiovascular events combined by 69 percent, fatal and nonfatal strokes by 73 percent, and all cardiac events combined by 63 percent in the group of patients with diabetes. Among the nondiabetic patients, active treatment decreased all cardiovascular events combined by 26 percent and fatal and nonfatal strokes by 38 percent. In the group of patients receiving active treatment, reductions in overall mortality, mortality from cardiovascular disease, and all cardiovascular events were significantly larger among the diabetic patients than among the nondiabetic patients (P=0.04, P=0.02, and P=0.01, respectively). CONCLUSIONS: Nitrendipine-based antihypertensive therapy is particularly beneficial in older patients with diabetes and isolated systolic hypertension. Thus, our findings do not support the hypothesis that the use of long-acting calcium-channel blockers may be harmful in diabetic patients.  (+info)

Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril. (4/3311)

1. We have measured arterial blood pressure between 115 and 145 days gestation in normally grown fetal sheep (control group; n = 16) and in fetal sheep in which growth was restricted by experimental restriction of placental growth and development (PR group; n = 13). There was no significant difference in the mean gestational arterial blood pressure between the PR (42.7 +/- 2.6 mmHg) and control groups (37.7 +/- 2.3 mmHg). Mean arterial blood pressure and arterial PO2 were significantly correlated in control animals (r = 0.53, P < 0.05, n = 16), but not in the PR group. 2. There were no changes in mean arterial blood pressure in either the PR or control groups in response to captopril (7.5 microg captopril min-1; PR group n = 7, control group n = 6) between 115 and 125 days gestation. After 135 days gestation, there was a significant decrease (P < 0.05) in the fetal arterial blood pressure in the PR group but not in the control group during the captopril infusion (15 microg captopril min-1; PR group n = 7, control group n = 6). 3. There was a significant effect (F = 14.75; P < 0.001) of increasing doses of angiotensin II on fetal diastolic blood pressure in the PR and control groups. The effects of angiotensin II were different (F = 8.67; P < 0.05) in the PR and control groups at both gestational age ranges. 4. These data indicate that arterial blood pressure may be maintained by different mechanisms in growth restricted fetuses and normally grown counterparts and suggests a role for the fetal renin-angiotensin system in the maintenance of blood pressure in growth restricted fetuses.  (+info)

The diameter of the common femoral artery in healthy human: influence of sex, age, and body size. (5/3311)

PURPOSE: To determine the relevance of dilatations of the common femoral artery (CFA), knowledge of the normal CFA diameter is essential. The diameter of the CFA in healthy male and female subjects of different ages was investigated. METHODS: The diameter of the CFA was measured in 122 healthy volunteers (59 male, 63 female; 8 to 81 years of age) with echo-tracking B-mode ultrasound scan. The influence of age, sex, height, weight, body surface area (BSA), and systolic blood pressure was analyzed by means of a multiple regression model. RESULTS: The CFA increased steadily in diameter throughout life. From 25 years onwards, the diameter was larger in men than in women. Significant correlations were found between the CFA diameter and weight (r = 0.58 and r = 0.57 in male and female subjects, respectively; P <.0001), height (r = 0.49 and r = 0.54 in male and female subjects, respectively; P <.0001), and BSA (r = 0.60 and r = 0.62 in male and female subjects, respectively; P <.0001). Age and BSA were used to create a model for prediction of the CFA diameter (r = 0.71 and r = 0.77 in male and female subjects, respectively; P <.0001). CONCLUSION: The diameter of the CFA increases with age, initially during growth but also in adults. This is related to age, body size, and sex male subjects have larger arteries than female subjects. It is now possible to predict the normal CFA diameter, and nomograms that may be used in the study of aneurysmal disease are presented.  (+info)

Acute exercise can improve cardioprotection without increasing heat shock protein content. (6/3311)

The aim of this study was to determine the effects of acute bouts of exercise on myocardial recovery after ischemia and heat shock protein expression. Adult female Sprague-Dawley rats were divided into five groups: 1) 1-day run (1DR; n = 6) and 2) 3-day run (3DR; n = 7), in which rats ran for 100 min at a speed of 20 m/min up a 6 degrees grade for 1 or 3 consecutive days; 3) 1-day cold run (1CR), in which rats ran the same as 1DR but with wet fur at 8 degrees C, which prevented an elevation of core temperature (n = 8); 4) heat shock sedentary (HS), in which rats had their core temperatures raised to 42 degrees C one time for 15 min (n = 5); and 5) sedentary control (n=15). Cardiac function was analyzed 24 h after the last treatment using an isolated, working heart model. Nonpaced hearts were initially perfused under normoxic conditions, then underwent 17 min of global, normothermic (37 degrees C) ischemia, and, finally, were allowed to recover for 30 min under normoxic conditions. The concentration of the 72-kDa heat shock protein (HSP 72) was measured in each left ventricle. Compared with that in the sedentary group, recovery of cardiac output x systolic pressure (CO x SP) was enhanced (P < 0.05) in all treatment groups when the postischemic value was covaried with the preischemic value. No differences in CO x SP were found (P > 0.05) between the following groups: 1DR vs. 3DR, 1DR vs. HS, and 1DR vs. 1CR. Heat shock protein concentration was significantly greater (P < 0.05) than that in the sedentary controls in HS, 1DR, and 3DR groups, but not for 1CR. The concentration of HSP 72 was not significantly correlated with postischemic CO x SP (R2 = 0.197, P > 0.05). We conclude that acute bouts of exercise can produce cardioprotective effects without an elevation of HSP 72.  (+info)

Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. (7/3311)

OBJECTIVES: We tested the hypothesis that regional end-systolic left ventricular (ESLV) wall stress is associated with extracellular matrix remodeling activity after myocardial infarction (MI). BACKGROUND: Increased left ventricular (LV) wall stress is a stimulus for LV enlargement, and echocardiography can be used to estimate regional wall stress. A powerful validation of a noninvasive method of estimating wall stress would be predicting cellular responses after a MI. METHODS: Echocardiographic images were obtained in rats 1, 7, 14 or 21 days after coronary ligation (n = 11) or sham surgery (n = 5). End-systolic left ventricular wall stress was calculated by finite element analysis in three regions (infarcted, noninfarcted and border) from short-axis images. Matrix metalloproteinase-9 (MMP-9) and macrophage density were determined by immunohistochemistry, and positive cells were counted in high power fields (hpf). RESULTS: Average ESLV wall stress was higher in rats with MI when compared to shams irrespective of time point (p < 0.01), and ESLV wall stress in the infarcted regions increased with time (25.1 +/- 5.9 vs. 69.9 +/- 4.4 kdyn/cm2, day 1 vs. 21; p < 0.01). Matrix metalloproteinase-9 expression was higher in infarcted and border regions when compared to noninfarcted regions (22.1 vs. 25.7 vs. 0.10 cells/hpf, respectively; p < 0.01). Over all regions, ESLV wall stress was associated with MMP-9 (r = 0.76; p < 0.001), macrophage density (r = 0.72; p < 0.001) and collagen content (r = 0.67; p < 0.001). End-systolic left ventricular wall stress was significantly higher when MMP-9 positive cell density was greater than 10 cells/hpf (45+/-20 vs. 14+/-10 kdyn/cm2; p < 0.001). CONCLUSIONS: Regional increases in ESLV wall stress determined by echocardiography-based structural analysis are associated with extracellular matrix degradation activity.  (+info)

Chordal force distribution determines systolic mitral leaflet configuration and severity of functional mitral regurgitation. (8/3311)

OBJECTIVES: The purpose of this study was to investigate the impact of the chordae tendineae force distribution on systolic mitral leaflet geometry and mitral valve competence in vitro. BACKGROUND: Functional mitral regurgitation is caused by changes in several elements of the valve apparatus. Interaction among these have to comply with the chordal force distribution defined by the chordal coapting forces (F(c)) created by the transmitral pressure difference, which close the leaflets and the chordal tethering forces (FT) pulling the leaflets apart. METHODS: Porcine mitral valves (n = 5) were mounted in a left ventricular model where leading edge chordal forces measured by dedicated miniature force transducers were controlled by changing left ventricular pressure and papillary muscle position. Chordae geometry and occlusional leaflet area (OLA) needed to cover the leaflet orifice for a given leaflet configuration were determined by two-dimensional echo and reconstructed three-dimensionally. Occlusional leaflet area was used as expression for incomplete leaflet coaptation. Regurgitant fraction (RF) was measured with an electromagnetic flowmeter. RESULTS: Mixed procedure statistics revealed a linear correlation between the sum of the chordal net forces, sigma[Fc - FT]S, and OLA with regression coefficient (minimum - maximum) beta = -115 to -65 [mm2/N]; p < 0.001 and RF (beta = -0.06 to -0.01 [%/N]; p < 0.001). Increasing FT by papillary muscle malalignment restricted leaflet mobility, resulting in a tented leaflet configuration due to an apical and posterior shift of the coaptation line. Anterior leaflet coapting forces increased due to mitral leaflet remodeling, which generated a nonuniform regurgitant orifice area. CONCLUSIONS: Altered chordal force distribution caused functional mitral regurgitation based on tented leaflet configuration as observed clinically.  (+info)

Clinical studies suggest that chorda-sparing mitral valve replacement techniques are associated with superior postoperative outcome, and several animal experiments have shown that disruption of the mitral subvalvular apparatus is followed by deterioration of left ventricular systolic function. One essential element, however, underlying the importance of chordal integrity for left ventricular function remains unproved: All investigators heretofore have been unable to demonstrate that left ventricular systolic performance can be restored by chordal reattachment after disruption of annular-papillary continuity. Therefore, we studied the effects of chordal detachment and subsequent chordal reattachment on left ventricular systolic performance using an in situ, isovolumic heart preparation in 10 halothane-anesthetized swine. The slope and left ventricular volume intercept of the isovolumic peak pressure-volume relationship were measured to assess global left ventricular systolic performance ...
Preoperative Systolic Strain Rate Predicts Postoperative Left Ventricular Systolic Function in Patients With Chronic Mitral Regurgitation: 18 Months Follow up ...
DeCara JM, Toledo E, Salgo IS, Lammertin G, Weinert L, Lang RM. Evaluation of left ventricular systolic function using automated angle-independent motion tracking of mitral annular displacement. J Am Soc Echocardiogr. 2005 Dec; 18(12):1266-9 ...
Description of disease Systole, premature. Treatment Systole, premature. Symptoms and causes Systole, premature Prophylaxis Systole, premature
Assessment of left ventricular (LV) systolic function is important for diagnosis, management, follow-up, and prognostic evaluation of patients in a variety of clinical settings. Accurate and reliable determination of LV systolic function is important
Background: Left ventricular (LV) myocardial strain and strain rate (SR) both depend upon afterload. However, the difference in the afterload dependency between these 2 indices has not been investigated.. Methods: Echocardiography was performed in 41 healthy volunteers before and during handgrip exercise. The handgrip exercise was performed at 50% of the maximum grasping power for 4 minutes. Meridional wall stress (MWS) was calculated from end-systolic LV dimension and wall thickness as well as systolic blood pressure. By using speckle tracking echocardiography, longitudinal peak strain (LS) and systolic peak SR (LSR) were measured and averaged in 3 apical views. These parameters were indicated in the absolute values.. Results: During handgrip exercise, systolic blood pressure increased from 98±11 to 116±15 mmHg and MWS increased from 660±130 to 975±174 dyn•mm-2 (%change: 49±18%). In response to this increase in MWS, LS decreased by 8.4±4.8% (from 17.2±1.7 to 15.7±1.4%). In comparison, ...
Overview Normal LV contraction Global & regional indices of LV systolic Function Angiographic assessments Echocardiography MRI Computed Tomography Nuclear Imaging Take home message
I recently had an echocardiogram to rule out infrequent weakness in both arms as being heart related. The report came back: normal chambers, normal left ventricular systolic function, EF 60-65%, norm...
RESULTS: There were 43 males (78.2%) and 12 females (21.8%). The mean age was 52.3±16.7 years (range: 15.5-76.4 years). A significant difference of GFI was found for preserved versus impaired systolic function of the left ventricle (preserved systolic function); GFI-M 2.28±0.60 versus 3.66±0.50 (p,0.001), and GFI-I 2.75±0.88 versus 3.81±0.87 (p,0.001), respectively. Diagnostic value was tested using receiver operating curve (ROC) analyzes, with GFI-M area under curve (AUC)=0.959 (95% CI: 0.868-0.994); (p,0.001) and GFI-I-AUC=0.847 (0.724-0.930); (p,0.001). GFI-M was superior to GFI-I for appraisal of left ventricle systolic dysfunction in HCM; ΔAUC=0.112 (0.018-0.207); (p=0.020 ...
Systo*le (?), n. [NL., fr. Gr. &?;, fr. &?; to contract; sy`n with + &?; to set, place.] 1. (Gram.) The shortening of ...
Words starting with S (page 241): systemizer, systemizes, systemizing, systemless, systems, systemwide, systole, systoles, systolic, systyle, sythe, syver, syzygal, syzygetic, syzygial, syzygies, syzygy...
TY - JOUR. T1 - Systolic time ratio by impedance cardiography to distinguish preserved vs impaired left ventricular systolic function in heart failure. AU - Thompson, Brenda. AU - Drazner, Mark H.. AU - Dries, Daniel L.. AU - Yancy, Clyde W.. PY - 2008/12/1. Y1 - 2008/12/1. N2 - Left ventricular ejection fraction (EF) is used to assess patients with heart failure (HF); however, frequent measurements are not cost-effective. Impedance cardiography (ICG) is a low-cost, noninvasive test that measures systolic time intervals and may be a method for detecting impaired vs intact EF. This study evaluated the relationship between EF by echocardiography or gated nuclear ventriculography and systolic time ratio (STR) by ICG in outpatients with chronic HF. A retrospective chart review identified 52 patients with EF and STR measured within 2 weeks. There was an inverse correlation between STR and EF (r=)0.54; P,.001). The area under the receiver operating characteristic curve for STR to identify reduced EF ...
Quantification of ventricular pump function is fundamental to the practice of cardiology and is required for research into most aspects of cardiac physiology, disease, and therapeutics. Drawing an analogy between the heart and a steam engine, Otto Frank (1) introduced the pressure-volume diagram as a means of characterizing left ventricular properties in the 1890s. Nearly 80 years later, Suga (2) formalized the idea that the relationship between pressure and volume at end systole was relatively independent of loading conditions and that the slope of the curve, called Emax or Ees, was a sensitive measure of contractility. At nearly the same time, several investigators demonstrated how the relationship between pressure and volume at end diastole similarly provided the framework for quantifying passive properties of the myocardium (3,4). In the decades to follow, there was intensive research into the characteristics of the end-systolic pressure-volume relation (ESPVR) and end-diastolic ...
The SCG signal is measured by placing an accelerometer on the torso which captures the induced vibration of the heart propagated to the surface of the chest. The feasibility of using seismocardiogram (SCG), in conjunction with ECG, for finding cardiac time intervals was first investigated in 1990s and has also been recently verified. Specific peaks of the SCG signal correspond to different events of the cardiac cycle (Fig. 1).. Systolic time intervals (STI) are important parameters that have been used for quantification of the performance of the heart and include the electro-mechanical systole, left ventricular ejection time (LVET), pre-ejection period (PEP) and isovolumetric-contraction. These parameters can be extracted from SCG as can be seen in the modified Wiggers diagram (Fig 1 ...
GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. Spirometry was normal (forced expiratory volume in the first second 2.9L, 95% predicted; forced vital capacity 3.6L, 91%; maximal expiratory flow 50 130%). There was poor R wave progression on ECG and an echocardiogram showed left ventricular hypertrophy with an estimated pulmonary artery systolic pressure of 44 mm Hg+right atrial pressure. Left ventricular systolic function was reported as good. He achieved 525 m on a 6-min walk with no desaturation on oximetry but he experienced significant breathlessness. A CT scan of the thorax demonstrated normal lungs with no evidence of interstitial or small airways disease and no pulmonary emboli. He scored 50/70 on the Hull Airway Reflux Questionnaire (HARQ).1 An airway pH study and barium swallow confirmed the presence of reflux.. AHM: The cardiac investigations are abnormal, but the reported good left ventricular systolic function suggests simple pump failure is unlikely. A ...
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OBJECTIVE To complement the ISO 5840 standards concerning the duration of left ventricular systole and diastole as a function of changes in heart rates according to in vivo studies from the physiologic literature review. METHODS The systolic and diastolic durations from three in vivo studies were compared with the durations of systole proposed by the ISO 5840:2010 and ISO 5840-2:2015 for hydrodynamic performance assessment of prosthetic heart valves. RESULTS Based on the in vivo studies analyzed, the systolic durations proposed by the ISO 5840 standard seemed consistent for 45 and 120 beats per minute (bpm), and showed diverse results for the 70 bpm condition. CONCLUSION Information on the realistic validation of the operation of left ventricular models for different heart rates were obtained.
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In this study we will investigate a method combining transoesophageal echocardiography and non-invasive finger arterial blood pressure waveforms to non-invasively construct pressure-volume (P-V) loops to describe the end-systolic pressure-volume relations in the heart. This may provide a method to obtain more insight on cardiac contractile function and the interaction of the heart with the vasculature during surgery ...
Background: Speckle tracking echocardiography (STE) provides novel insight into both global and regional systolic and diastolic function. There are both vendor-dependent (2D strain-GE Healthcare-2DS) and vendor-independent (Cardiac Performance Analysis-CPA-TomTec Imaging Systems-VVI) analysis algorithms that are available. Accordingly our aim was (1) to establish reference values for strain (ε) and systolic synchrony and (2) to determine whether the two different STE methods provide similar data.. Methods: 27 consecutive normal subjects were studied (average age 47 years, 72% female). DICOM data were analyzed with EchoPac (GE) and CPA (TomTec) software, offline. The peak principal strains, longitudinal (εl), circumferential (εc), and radial (εr) were derived by both 2DS and VVI STE. We also computed time to peak maximal ε (TPkε) for all ε values, and between corresponding wall segments.. Results: (see Table)ε values obtained by VVI were comparable to those obtained by 2DS for εl and ...
Systolic hypertension in the elderly is a common clinical problem which represents a major therapeutic dilemma. The magnitude of the problem is increasing as the population of individuals over 50...
Isolated systolic hypertension information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Dans lespace projectif complexe, les lieux de zéros de polynômes génériques complexes homogènes de même degré ont ceci de très particulier, quils sont tous difféomorphes. En particulier, dans le plan projectif complexe, les courbes lisses complexes de même degré sont des surfaces de Riemann connexes de même genre. Si lon équipe ces courbes de la restriction de la métrique ambiante et si lon choisit au hasard la courbe, à quoi peut-on sattendre concernant la taille de sa systole ? Je fournirai une réponse partielle à cette question, analogue à un résultat de M. Mirzakhani pour les surfaces hyperboliques aléatoires. En dimension supérieure, il savère que ce type dargument probabiliste permet de démontrer un résultat \emph{déterministe} concernant les sous-variétés lagrangiennes et lhomologie des hypersurfaces projectives équipées de la restriction de la forme symplectique ambiante ...
Measurement of BNP could be a cost-effective method of screening for left-ventricular systolic dysfunction in the general population, especially if its use were targeted to individuals at high risk.
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Answer The tie is between B and D We know in hypertensive hearts LV primarily fails in diastole . Lungs get congested due to raised LVEDP .Here is a catch . . . if diastole is terribly dysfunctional how can be systole be near normal ? (After all . . . systole is not…
We show that for closed orientable manifolds the k-dimensional stable systole admits a metric-independent volume bound if and only if there are cohomology classes of degree k that generate cohomology in top-degree. Moreover, it turns out that in the nonorientable case such a bound does not exist for stable systoles of dimension at least two. Additionally, we prove that the stable systolic constant depends only on the image of the fundamental class in a suitable Eilenberg-MacLane space. Consequently, the stable k-systolic constant is completely determined by the multilinear intersection form on k-dimensional cohomology.
Gabacap: dr. ellwood. now maybe when you are in a medicare age group. gabacap 100mg force during the systole and thus the work is increased beyond the
Along with others, we have found that many patients presenting with heart failure have preserved left ventricular systolic function. 1-3 10-15 While these patients may have diastolic dysfunction it is also possible that there are other explanations for their symptoms. The problem about making a diagnosis of diastolic heart failure non-invasively is that there is no agreement on how this should be done, and different criteria for diastolic dysfunction give enormously differing prevalences. 2 16 One of the most commonly used criterion, an E:A ratio of ,1, showed that most of our patients with heart failure and preserved left ventricular systolic function could be said to have diastolic dysfunction. Rather than examine the vexed issue of how one defines diastolic dysfunction with echocardiography we have examined an alternative-that is, could there be another explanation for these patients symptoms?. The most obvious alternative diagnoses are obesity, respiratory disease, and myocardial ...
Results Conventional echocardiographic measurements (LV end diastolic diameter, LV end systolic diameter and LV EF) were similar between the groups. Longitudinal peak systolic strain (13.20±3.5% to 20.97±4.5%, p=0.0001) and strain rate (0.23±0.18 1/s to 4.92±0.55 1/s, p=0.0001) of the LV were significantly impaired in patients with TA, compared to controls, demonstrating subclinical ventricular systolic dysfunction. Supporting these results, we revealed impaired subclinical LV systolic function in patients with SLE, when compared to the control group (14±4.53% to 20.97±4.5%, p=0.0001 for strain; 0.23±0.12 1/s to 4.92±0.55 1/s, p=0.0001 for strain rate). The mean disease duration of the patient was 5.6 years in patients with TA. The LV systolic dysfunction was negatively correlated with disease duration, but this correlation couldnt reach the statistical significance(r=-0,085, p=0,648.). ...
Looking for online definition of atrial systole in the Medical Dictionary? atrial systole explanation free. What is atrial systole? Meaning of atrial systole medical term. What does atrial systole mean?
TY - JOUR. T1 - Left ventricular function after coronary artery bypass. Non-invasive study by systolic time intervals. AU - de Caprio, L.. AU - Rengo, F.. AU - Spampinato, N.. AU - Carlomagno, A.. AU - Chiariello, L.. AU - Spinelli, L.. AU - Romano, M.. PY - 1980. Y1 - 1980. UR - http://www.scopus.com/inward/record.url?scp=0018942327&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018942327&partnerID=8YFLogxK. M3 - Article. C2 - 6970482. AN - SCOPUS:0018942327. VL - 35. SP - 93. EP - 105. JO - Acta Cardiologica. JF - Acta Cardiologica. SN - 0001-5385. IS - 2. ER - ...
Assessment of cardiac structure and function is central to the care of patients with heart disease. Cardiac magnetic resonance (CMR) is the gold standard for such assessment, however it is expensive and oftentimes not readily accessible. We sought to evaluate the utility of electrocardiographic (ECG) and impedance-based parameters in estimating the amount of myocardial scar, left ventricular (LV) systolic function and myocardial deformation. Consecutive patients (n = 241; 42% female; mean age 55 years) undergoing clinical CMR and ECG assessments were recruited. ECG analysis was performed manually, using both the Modified Selvester Score (MSS) and the presence of fractionated QRS (fQRS) signals, and impedance testing using the Non-Invasive Cardiac System (NICaS). While MCS was of value, neither fQRS nor NICaS meaningfully predicted scar extent, LV systolic function. Or the amount of myocardial deformation. These results support additional investigation of the utility of the MSS in estimating ...
1. In the anesthetized dog, end-diastolic, end-systolic and stroke volumes for the left ventricle have been calculated according to the method of Holt from dilution curves recorded at the aortic root. For heart rates of less than 120 beats per minute, the catheterdensitometer systems used gave 90 to 95 per cent of the true concentration in the aortic root at the end of diastole.. 2. Average volumes of 2.96, 1.63 and 1.33 ml./Kg. of body weight were calculated for each of these parameters. The interindividual and intraindividual variations about these means amounted to ± 30 to 50 per cent.. 3. In approximately 15 per cent of the dilution curves the concentration of dye in the aortic root during early systole (phase of maximal ejection) showed a transient, markedly low value compared with that of the end of diastole. This can be explained only on the basis of the preferential ejection from the heart in early systole of the undyed, newly entering blood from the left atrium, which had mixed poorly ...
The federal Agency for Health Care Policy and Research has published its second set of guidelines in the field of internal medicine. These guidelines outline a comprehensive plan for the treatment of heart failure. They focus on the practical aspects of the management of patients with heart failure due to reduced left ventricular systolic performance (ejection fractions , 35% to 40%). They also offer expert opinion in the diagnosis and evaluation of heart failure and review clinical criteria for admission and discharge of these patients. Prevention of heart failure is a major focus of these current guidelines. ...
in Lancet (2011), 378(9792), 676-83. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are ... [more ▼]. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are characteristic of systolic heart failure and might be improved by a new therapeutic class, cardiac myosin activators. We report the first study of the cardiac myosin activator, omecamtiv mecarbil, in patients with systolic heart failure. METHODS: We undertook a double-blind, placebo-controlled, crossover, dose-ranging, phase 2 trial investigating the effects of omecamtiv mecarbil (formerly CK-1827452), given intravenously for 2, 24, or 72 h to patients with stable heart failure and left ventricular systolic dysfunction receiving guideline-indicated ...
in Lancet (2011), 378(9792), 676-83. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are ... [more ▼]. BACKGROUND: Many patients with heart failure remain symptomatic and have a poor prognosis despite existing treatments. Decreases in myocardial contractility and shortening of ventricular systole are characteristic of systolic heart failure and might be improved by a new therapeutic class, cardiac myosin activators. We report the first study of the cardiac myosin activator, omecamtiv mecarbil, in patients with systolic heart failure. METHODS: We undertook a double-blind, placebo-controlled, crossover, dose-ranging, phase 2 trial investigating the effects of omecamtiv mecarbil (formerly CK-1827452), given intravenously for 2, 24, or 72 h to patients with stable heart failure and left ventricular systolic dysfunction receiving guideline-indicated ...
The dilemma of isolated systolic hypertension.: Isolated systolic hypertension, characterized by elevated systolic blood pressure (greater than 150 to 165 mm Hg
Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhäger WH, Bulpitt CJ, de Leeuw PW, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, OBrien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997; 350(9080): 757-64 ...
STI were measured on the 7th day after acute myocardial infarction in 144 male patients. These patients were reviewed at 6 weeks and 86 were reinvestigated and reviewed at 6 months. The STI could not predict the patients who would have either angina
now, today well be talking about the cardiac cycle. and the cardiac cycle well be discussing in two fashions, and one way we will discussing cardiac cycle while I will be doing different diagrams and in second phase, Well discuss the cardiac cycle Uhhhhh, When I will be presenting the errands during the cardiac cycle Graphically So first of all, ...
Among this large group of young and middle-aged treated hypertensive subjects, IDH proved to be a favorable finding. By contrast, a wide pretreatment PP was strongly associated with the occurrence of MI despite successful treatment. Among subjects who had MI before age 60, pretreatment diastolic pressure was similar to that of subjects who did not experience events.. Moreover, when subjects with IDH were further stratified by systolic pressure above or below 140 but still less than 160 mm Hg, it was found that MIs occurred exclusively among those with borderline systolic hypertension. No subject with a systolic BP below 140 mm Hg experienced an MI regardless of the level of diastolic pressure (90 to 115 mm Hg).. Subjects with SDH were older and had higher cholesterol and blood glucose levels and were more likely to be female, smoke cigarettes, and have LVH on ECG than IDH subjects. All BP measures in the SDH group were higher than in the IDH group. Clearly, these factors help to explain the ...
Casartan(candesartan): For the management of hypertension and heart failure in patients with impaired left ventricular systolic function, either when angio
Staessen, JA; Fagard, R; Thijs, L; Celis, H; Arabidze, GG; Birkenhager, WH; Bulpitt, CJ; de Leeuw, PW; Dollery, CT; Fletcher, AE; +8 more... Forette, F; Leonetti, G; Nachev, C; OBrien, ET; Rosenfeld, J; Rodicio, JL; Tuomilehto, J; Zanchetti, A; (1997) Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet, 350 (9080). pp. 757-764. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(97)05381-6 Full text not available from this repository ...
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Figure 3.1 illustrates the geometric relationships between the LFT (Marker#29), APT (Marker#31), SH (Marker#22), RFT (Marker#24), and PPT (Marker#33) for diastole (left panel) and systole (right panel).. ...
Tricuspid Annular Plane Systolic Excursion [TAPSE] in a patient with severe PAH during a vasodilatory test with epoprostenol: Left panel depicts the localizatio
TY - JOUR. T1 - Left ventricular global systolic function assessment by echocardiography. AU - Chengode, Suresh. PY - 2016/10/1. Y1 - 2016/10/1. N2 - The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function quantification, needs intensive, 2D, 3D and M mode transesophageal echocardiography, which is described in this review.. AB - The left ventricle, with its thickened myocardial walls, unlike the right ventricle has no measurable geometric shape. It has a conical apex and its function quantification, needs intensive, 2D, 3D and M mode transesophageal echocardiography, which is described in this review.. KW - Echocardiography. KW - Intraoperative or intensive care setting. KW - Left ventricular global systolic function. UR - http://www.scopus.com/inward/record.url?scp=84993953630&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84993953630&partnerID=8YFLogxK. U2 - ...
Background Right ventricular ejection fraction (RVEF) is an emerging prognostic predictor of patients with pulmonary hypertension (PH).. Aim We sought to evaluate the accuracy and suitability of two echocardiographic parameters of right ventricular systolic function: tricuspid annular plane systolic excursion (TAPSE) and systolic lateral tricuspid annular motion velocity (TVlat) in the monitoring of RVEF of PH patients.. Methods Consecutive 37 patients with PH (median pulmonary arterial pressure 36 (28 -43) mmHg) were studied. We measured TAPSE and TVlat as echocardiographic indices of RVEF. TAPSE and TVlat measured at baseline and at follow-up, and the changes during follow-up were compared with those of magnetic resonance imaging (MRI)-derived RVEF. Receiver operating characteristic (ROC) analysis was conducted to calculate the cut-off levels of TAPSE and TVlat for the identification of patients with improved RVEF.. Results TAPSE and TVlat were significantly correlated with MRI-derived RVEF at ...
Life expectancy < 3 months Renal insufficiency Pregnant Unable to follow-up All enrolled patients had a TTE performed by cardiologists looking for signs of RV dysfunction, including TAPSE on A4C. Study outcomes: All-cause mortality at 30 days, secondary outcome was PE-specific mortality Results:. 782 patients were included (66 others were removed due to incomplete TTE documentation, those excluded did not differ in terms of demographics, past history, clinical presentation). All were anticoagulated.. TAPSE range was 0.9-4.0 cm, with a median of 2.0 cm. ROC Curve analysis showed that the best cut-off for PE was 1.6 cm. 146 of the 782 patients had a TAPSE of < 1.6 cm. These patients were older, less likely to be male, had a higher prevalence of chronic heart disease or AFib, and more signs of clinical severity (syncope, tachycardia, low sats, hypotension [Editor note: presumably only brief episodes of hypotension since a normal blood pressure was required for inclusion]). 35 patients died by 30 ...
This study shows a substantial benefit with atorvastatin therapy in patients with systolic HF due to a nonischemic etiology. The LV systolic function improved significantly in the cohort of patients treated with atorvastatin, compared with a decline in systolic function in patients treated with placebo over the 12-month study period. In addition, there were reductions in both LV end-diastolic and end-systolic dimensions in the atorvastatin group when compared with placebo. These findings suggest that atorvastatin might retard the progression of adverse myocardial remodeling in patients with nonischemic HF. Finally, atorvastatin therapy was associated with reductions in levels of hsCRP, TNF-α RII, and IL-6 as well as an increase in E-SOD activity, suggesting an association between changes in pro-inflammatory and pro-oxidative markers and LV systolic function.. The patients in our study were largely either NYHA functional class II or III in symptoms. Baseline medical therapy was good, with 88% of ...
BACKGROUND: Myocardial dysfunction in children diagnosed with mitochondrial disease is an ominous sign and has been associated with substantial increased mortality rates. Early detection of cardiac involvement would therefore be desirable. Two dimensional strain echocardiography (2DSTE) has proven to be more sensitive than conventional echocardiography for the detection of early myocardial dysfunction in various (cardiac) conditions. AIMS: To determine left ventricular systolic function in children with mitochondrial disorders by means of physical examination, electrocardiography (ECG), conventional echocardiography and 2DSTE. METHODS: A total of 27 children with established mitochondrial disease and 54 age-matched control subjects underwent cardiac evaluation. Longitudinal, circumferential and radial peak systolic strain (S) values were determined as well as peak systolic strain rate (Sr) and the time to peak global systolic strain (T2P). One Way analysis of Variance was performed to assess the ...
CHAPTER II: CARDIAC MECHANICS Asst. Prof. Dr. Emre Hamurtekin EMU Faculty of Pharmacy 1. 2. 3. 4. CARDIAC CYCLE CARDIAC OUTPUT DETERMINANTS of CARDIAC OUTPUT CARDIAC WORK encyclopedia.lubopitko-bg.com medical-dictionary.thefreedictionary.com • Cardiac cycle can be divided into seven phases: 1. Atrial systole 2. Isovolumic ventricular contraction 3. Rapid ventricular ejection 4. Reduced ventricular ejection 5. Isovolumic ventricular relaxation 6. Rapid ventricular filling 7. Reduced ventricular filling • Atrial systole is initiated by …………………... atrial excitation • Atrial systole follows the crest of P wave on the ECG. • Atrial contraction forces a small additional blood into the venticular chamber (atrial kick). • Ventricular systole begins with isovolumic ventricular contraction. • In isovolumic ventricular contraction, when intraventricular pressure rises, mitral valve closes. • In isovolumic ventricular contraction, aortic valve is still held closed by higher ...
Hemodynamic and left ventricular systolic function were studied by Doppler echocardiography in 14 young and 15 older adult hypertensive patients and in 15 young and 12 older normotensive individuals. Measures were made at rest and during upright deadlift isometric exercise, at 30% of maximum voluntary contraction for 3 min. At rest, young and older hypertensive patients demonstrated impaired left ventricular systolic function compared to both old and young normotensive subjects. The impaired systolic function was associated with less augmentation in systolic indices during exercise compared with resting values in young and elderly hypertensive patients, and to a lesser degree in the normotensive elderly when compared with young normotensives. These data indicate that at rest, left ventricular systolic function may be compromised in hypertensive patients with left ventricular hypertrophy and, to a lesser extent, in the normotensive elderly. However, other factors in chronic hypertension may ...
Assessing left ventricular global systolic function, left ventricular dysfunction, cardiomyopathy and cardiac decompensation on MedMastery
Myocardial function can be evaluated using color-coded tissue velocity imaging (TVI) to analyze the longitudinal myocardial velocity profile, and by expressing the motion of the atrioventricular plane during a cardiac cycle as coordinated events in the cardiac state diagram (CSD). The objective of this study was to establish gestational age specific reference values for fetal TVI measurements and to introduce the CSD as a potential aid in fetal myocardial evaluation. TVI recordings from 125 healthy fetuses, at 18 to 42 weeks of gestation, were performed with the transducer perpendicular to the apex to provide a four-chamber view. The myocardial velocity data was extracted from the basal segment of septum as well as the left and right ventricular free wall for subsequent offline analysis. During a cardiac cycle the longitudinal peak velocities of septum increased with gestational age, as did the peak velocities of the left and right ventricular free wall, except for the peak velocity of post ejection.
Magnetic resonance tagging was used to calculate myocardial strains (15). All studies were obtained on a 1.0-tesla MR unit (Siemens, Erlangen, Germany). Tags are noninvasive markers placed on the myocardium by presaturating planes at end-diastole perpendicular to the subsequent imaging planes. They show up on the images as dark lines that move and deform with the myocardium on which they are inscribed. Five parallel short-axis planes and four radially oriented long-axis planes crossing the center of the LV were defined (Fig. 1). The gravitational centerline of the LV cavity was reached by the best fit connecting the center of the cavity at each of the different short-axis levels. Images were acquired at end-diastole and end-systole in all these planes, using the short-axis planes as tagging planes for the long-axis images and vice versa. By combining the short- and long-axis information, the entire LV wall, except for the apex, could be reconstructed into 32 small cuboids for which the ...
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.
The aim of this study was to investigate early changes in left ventricular longitudinal systolic function in patients with hypertension (HTN) with and without concomitant diastolic dysfunction (DD) and the clinical implications of these findings. We enrolled 299 patients with HTN and 297 age-matched patients with HTN and DD and compared both groups with an age-matched control group consisting of 100 healthy subjects. The long axis systolic function was investigated by determining the average peak systolic velocity of the septal and lateral mitral sites (Smavg) using spectral pulsed wave tissue Doppler imaging (TDI). We found a strong negative trend toward the reduction of velocity, which is dependent on the grade of HTN, on the magnitude of DD, and also on the gender and age of the subjects (r=−0.891/-0.580; p|0.0001). The data showed that the beginning and evolution of HTN are related to a slight but significant reduction in the long axis systolic function (10.2-10.0 cm/s; p|0.0001), and DD worsens
The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and middle-aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] ,120 mm Hg and diastolic BP [DBP] ,80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP ,90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP ,140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178 ...
Synonyms for systole and diastole at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
To the Editor:. The JNC-7 guidelines suggested that diastolic blood pressure (DBP) should not be aggressively lowered below 55 to 60 mm Hg because of possible increase in cardiovascular events associated with lower values (pages 1222 and 1229 of the report).1 This conclusion was mainly derived from results of the Systolic Hypertension in the Elderly Program (SHEP).2 However, the committee did not provide similar cutoffs for systolic blood pressure (SBP). In that respect, we are concerned about the experts statement that no increase in coronary events (or J-shaped relationship) has been observed with excessive lowering of SBP (page 1222).1 Indeed, analysis of 7 randomized trials, including the SHEP, suggested that there may be increased risk of cardiovascular and all-cause mortality with lower levels of DBP as well as SBP.3 While the JNC-7 defined a clear goal for control of SBP (,140 mm Hg, and ,130 mm Hg in patients with diabetes and chronic kidney disease), the extent to which SBP must be ...
Mechanistic studies will provide insight into how CCM improves LV function. We observed that CCM did not just augment contractility at the septal and adjacent walls where the 2 electrodes were placed; rather, systolic function was enhanced in the entire LV including the free-wall segments. Therefore, in the long run, the concerted force in all 6 regions of the LV would contribute to the improvement of LV global systolic function, resulting in LV reverse remodeling and reduction of mitral regurgitation. These findings are completely consistent with a recent report concerning CCM-induced reverse molecular remodeling (8). When HF was experimentally induced in animals, there was a switch in expression of a host of genes from a normal adult genotype to a fetal genotype indicative of myocardial pathology. In such animals, Imai et al. (8) showed that within hours of initiating CCM signal delivery, there was a reversion back towards a normal genotype only in the region of the heart where signals were ...
Two players must pump a human heart by clicking two buttons in coordination: one acts as the systole movement, the other as the diastole. Pictures indicate what the character is doing, so the players must reproduce the heart rate according to the activity (e.g., running). The heart will receive damage (and eventually die) if the players press their buttons at the same time or if they play the wrong rhythm. When they keep pumping the heart to match the correct heartbeat for a short amount of time, they pass to a new activity. Aim for a high score! Tried in Chrome & Firefox. Best played with headphones ...
I clicked here to discover what in the heck diastolic hypertension is and how to treat it. Everyone knows about high blood pressure, and how it can cause a host
Question - What is the normal blood pressure for 62 years old?. Ask a Doctor about diagnosis, treatment and medication for Systolic hypertension, Ask a General & Family Physician
Includes detailed diagrams of circulation, anterior heart, posterior heart, interior heart, nerves & arteries, beginning of diastole, end of diastole, systole, end of systole, heart in diastole and heart in systole ...
single-channel video, collaboration with Caspar Stracke, 2.58 min. Kuleshov Sukiyaki is inspired by, and maintains as its soundtrack, Terre Thaemlitzs Systoles compositions.. In his album INTERSTICES, Terre Thaemlitz describes: …systole in prosody means the shortening of a naturally long syllable, systolic composition procedurally refers to the shortening of sound sources by removing primary passages in order to create new compositions. In Systoles, the passages most commonly deleted are vocals, in order to hear the interstitial sounds at their periphery. Often times the remnants of a singers inhalation and exhalation can be heard in the remaining passages, suggesting emotional, physical and/or sexual exasperation, and occasionally resulting in the whispering of new words…. ...
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Doppler Measurements & Calculations: MV E max vel: 83 cm/sec, MV A max vel: 86 cm/sec, MV E/A:0.96, MV dec time: 0.24 sec, Ao V2 max: 136cm/sec, Ao max PG: 7.0mmHg, LV max PG:3.0mmHg, LV V1 max:90 cm/sec, TR max vel: 204 cm/sec, TR max PG:17 mmHg,RVSPC(TR):22mmHg, RAP systole:5.0 ...
dangerous a remedy to use for such purposes. Digitalis is of service only for a few days at a time at the longest. It should only be given to influence...In such instances as these it will tighten up the 53G 537 vessels, and, by augmenting the power of the systole, will force a larger volume of blood into ...
Diastole   Diastole (pronounced di-as´to-le, rhymes with potentially) is the period of time when the heart relaxes after contraction. Ventricular
Berger, M.: Systoles et applications selon Gromov. (French. French summary) [Systoles and their applications according to ... More details appear at systoles of surfaces. The deepest result in the field is Gromov's inequality for the homotopy 1-systole ... The systole of a compact metric space X is a metric invariant of X, defined to be the least length of a noncontractible loop in ... The actual term "systole" itself was not coined until a quarter century later, by Marcel Berger. This line of research was, ...
Berger, M.: Systoles et applications selon Gromov. (French. French summary) [Systoles and their applications according to ... In geometry, a systole is a distance which is characteristic of a compact metric space which is not simply connected. It is the ... The actual term systole itself was not coined until a quarter century later, by Marcel Berger. This line of research was, ... Berger, M.: What is... a Systole? Notices of the AMS 55 (2008), no. 3, 374-376. Buser, P.; Sarnak, P.: On the period matrix of ...
Systole, least length of a noncontractible loop. Tangent bundle, the vector bundle of tangent spaces on a differentiable ...
This beginning of the atrial systole is known as the atrial kick-see Wiggers diagram. The atrial kick does not supply the ... That is, for a typical heart rate of 75 beats per minute (bpm), the cycle requires 0.3 sec in ventricular systole (contraction ... Systole (medicine) Blood pressure Wiggers diagram Diastole. Merriam-Webster Online Dictionary. 24 August 2008. Widmaier, Eric P ... In summary, when the ventricles are in systole and contracting, the atria are relaxed and collecting returning blood. When, in ...
Systole [1] Ghettoblaster Magazine, June 24, 2015. [2] MusicBox Pete June 29, 2015 "Hawking Introduces Us To Math Pop". Baeble ...
Katz, Mikhail G.; Schaps, Mary; Vishne, Uzi (2007), "Logarithmic growth of systole of arithmetic Riemann surfaces along ... and Vishne to construct a family of Hurwitz surfaces satisfying an asymptotic lower bound for the systole: s y s > 4 3 log ⁡ g ... see systoles of surfaces. (2,3,7) triangle group Klein quartic Macbeath surface First Hurwitz triplet Vogeler, Roger (2003), On ...
Note how the right atrial collapses during systole. Play media Ultrasound image of the inferior vena cava (IVC) in a person ...
Ventricular systole Cardiac diastole ECG The EKG complex. P=P wave, PR=PR interval, QRS=QRS complex, QT=QT interval, ST=ST ...
The increased workload may also be associated with a higher heart rate, a proportionately longer duration of systole and a ... This increases the load on the heart in systole. John R. Cockcroft, notable researcher on the subject Pulse wave velocity ... is increased in stiffer arteries and consequently reflected waves will arrive at the heart earlier in systole. ...
Occurs during systole or continuously during both systole and diastole. (Murmurs occurring only during diastole are usually ...
Volume 1. "CITOLE, also spelled Systole, Cythole, Gytolle, &c. (probably a Fr. diminutive form of cithara, and not from Lat. ...
These two phases are commonly understood as systole and diastole. The rest phase is considered polarized. The resting potential ...
Vesalius believed that cardiac systole is synchronous with the arterial pulse. He not only verified Estienne's findings on the ...
doi:10.1016/0022-314x(82)90028-2. Katz, M.; Schaps, M.; Vishne, U. (2007). "Logarithmic growth of systole of arithmetic Riemann ...
Logarithmic growth of systole of arithmetic Riemann surfaces along congruence subgroups. J. Differential Geom. 76 (2007), no. 3 ...
When ventricular systole ends, pressure in the left ventricle rapidly drops. When the pressure in the left ventricle decreases ... When the left ventricle contracts (systole), pressure rises in the left ventricle. When the pressure in the left ventricle ...
ISBN 978-3-540-69113-6. Katz, M.; Schaps, M.; Vishne, U. (2007). "Logarithmic growth of systole of arithmetic Riemann surfaces ... as well as systoles of Fuchsian subgroups) can be calculated by means of the reduced trace in the quaternion algebra, and the ...
Myofibrils are mostly arranged circularly and constrict the heart during systole. There are two valves present, an anterior ...
The peak of the 'a' wave demarcates the end of atrial systole. The x descent follows the 'a' wave and corresponds to atrial ... wave and occurs as a result of the right ventricle pulling the tricuspid valve downward during ventricular systole (ventricular ... ventricular contraction and resulting bulging of tricuspid into the right atrium during isovolumetric systole) and "v" = venous ...
In contrast to a Blalock-Taussig shunt, circulation is primarily in systole.[citation needed] It is sometimes used as the first ...
Pulsatile This description of the pulse implies the intrinsic physiology of systole and diastole. Scientifically, systole and ... This pulse signals a flagging effort of the heart to sustain itself in systole. Pulsus bigeminus: indicates a pair of hoofbeats ... Pressure waves generated by the heart in systole move the arterial walls. Forward movement of blood occurs when the boundaries ...
This added volume of blood must be pumped out during ventricular systole. The rapid flow of blood during systole is thought to ... During systole, the narrowing of the LVOT creates a more negative pressure due to the Venturi effect and sucks in the anterior ... Towards the end of systole, the ventricle is able to overcome the obstruction to cause the second rise in the aortic waveform. ... that an alternative explanation for pulsus bisferiens may be due to a forward moving suction wave occurring during mid-systole ...
Bruits heard in the epigastrium that are confined to systole are considered normal. The examiner should first talk to the ...
This follows by combining the diameter upper bound mentioned above with Gromov's lower bound in terms of the systole (Gromov, ... 1983) The systole of an essential manifold M is at most six times its filling radius, see (Gromov, 1983). The inequality is ... the filling radius is a sixth of the systole in these cases. The filling radius of the Riemannian circle of length 2π, i.e. the ...
During systole the mean velocity rises to a peak, then it falls during diastole. This pattern is repeated with each squeezing ... The highest velocities are found at the exit of the valve during systole. At this stage the majority of the flow can be ... The VAD is driven by a pump with a waveform to replicate the systole and diastole of the flow. When the pump is running, the ...
The energy that drives the suction process is generated from phase of systole. During systole, to overcome the peripheral ... diastolic intervals consist of early rapid filling E-waves followed by diastasis and followed by atrial systole-generated A- ...
Katz, M.; Schaps, M.; Vishne, U.: Logarithmic growth of systole of arithmetic Riemann surfaces along congruence subgroups. J. ...
Systole is represented by the sin function, while flow during diastole is zero. s represents the duration of the cardiac cycle ... An example for the two-element model is shown below, where I(t) is depicted as an input signal during systole and diastole. ... These arteries distend when the blood pressure rises during systole and recoil when the blood pressure falls during diastole. ... The historic mathematical definition of Systole and Diastole in the model are obviously not novel but are here elementally ...
The invariant is defined in terms of the systoles of M and its covers, as the largest number of systoles in a product yielding ... The systole (or systolic category) is a numerical invariant of a closed manifold M, introduced by Mikhail Katz and Yuli Rudyak ... Katz, M.; Rudyak, Y. (2008) Bounding volume by systoles of 3-manifolds. Journal of the London Mathematical Society 78, no 2, ...
This approach is only valid when wave reflections are absent or minimal, this is assumed to be the case in early systole. A ... It is widely assumed that reflections are minimal during late diastole and early systole. With this assumption, PWV can be ... and the linear portion during early systole, when reflected waves are assumed to be minimal, can be used to calculate PWV. ...
Systole may refer to: Systole (medicine), a term describing the contraction of the heart Systolic array, a term used in ... surfaces Also see Introduction to systolic geometry This disambiguation page lists articles associated with the title Systole. ... computer architecture Systolic geometry, a term used in mathematics In mathematics, Systoles of surfaces are systolic ...
systole: Period of contraction of the ventricles of the heart that occurs between the first and second heart sounds of the ... In an ECG, atrial systole is associated with atrial depolarization, or the P wave deflection. "Systole" may also refer to the ... Systole causes the ejection of blood into the aorta and pulmonary trunk. Lasting usually 0.3 to 0.4 second, ventricular systole ... Systole, period of contraction of the ventricles of the heart that occurs between the first and second heart sounds of the ...
Systo*le (?), n. [NL., fr. Gr. &?;, fr. &?; to contract; sy`n with + &?; to set, place.] 1. (Gram.) The shortening of ...
doi:10.1090/S0002-9939-05-08057-3. Katz, M.; Schaps, M.; Vishne, U. (2007). "Logarithmic growth of systole of arithmetic ... Namely, they exhibited arithmetic hyperbolic Riemann surfaces with systole behaving as a constant times log ⁡ ( g ) {\ ... its systole, denoted sys, is defined to the least length of a loop that cannot be contracted to a point on the surface. The ... of the systole of hyperbolic surfaces reveals some interesting constants. Thus, Hurwitz surfaces Σ g {\displaystyle \Sigma _{g ...
Create healthcare diagrams like this example called Atrial Systole in minutes with SmartDraw. SmartDraw includes 1000s of ... Atrial Systole. Create healthcare diagrams like this example called Atrial Systole in minutes with SmartDraw. SmartDraw ... Atrial Systole. Changes in heart structure during atrial systole.. LifeART Collection Images Copyright © 1989-2001 by ...
Here, we discuss the difference between diastole and systole and the risks of hypertension (high) and hypotension (low) blood ... What are diastole and systole?. Diastole is when the heart muscle relaxes and systole is when the heart muscle contracts. ... The terms diastole and systole refer to when the heart muscles relax and contract. The balance between diastole and systole ... Systole is when the heart muscle contracts.. *When the heart contracts, it pushes the blood out of the heart and into the large ...
Premature systole definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ...
Systole is the last stage of a heart beat. It happens right after diastole, when the heart refills with blood. During systole, ... During systole, the heart muscle gets an automatic electrical signal that tells the heart to contract (squeeze). This makes the ... Blood causes the most pressure against the walls of the arteries when it is being pushed out during systole). The lowest ... "Systole definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms". Medterms.com. ...
... on WN Network delivers the latest Videos and Editable pages for News & Events, including Entertainment, Music, Sports, ... Systole. Systole /ˈsɪstəliː/ is the part of the cardiac cycle when the ventricles contract. The term "systole" originates from ... Systole. Systole /ˈsɪstəliː/ is the part of the cardiac cycle when the ventricles contract. The term "systole" originates from ... The notion of systole. The systole of a compact metric space X is a metric invariant of X, defined to be the least length of a ...
... for left ventricular strain measurement during the systole using cine-gated... ... The Hyperelastic Warping solution was evolved using a series of non-tagged images in 10 phases from end-diastole to end-systole ... Strain Measurement in the Left Ventricle During Systole with Deformable Image Registration. ... Strain Measurement in the Left Ventricle During Systole with Deformable Image Registration. In: Sachse F.B., Seemann G. (eds) ...
Gene context of Systole. *LV wall thickness during systole and % fractional shortening were diminished by 8-10% in Cx43- ... Energy levels at systole vs. diastole in normal hamster hearts vs. myopathic hamster hearts. Sievers, R., Parmley, W.W., James ... Atrial systole and left ventricular filling in hypertrophic cardiomyopathy: effect of verapamil. Bonow, R.O., Frederick, T.M., ... Effect of increased adrenergic activity on the relationship between electrical and mechanical systole. Boudoulas, H., Geleris, ...
We provide competent support to help you find the right specialist - free of charge, confidentially and with the highest medical quality. This is what the Leading Medicine Guide stands for with its strict admission criteria.. ...
Synonyms for systole and diastole at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word ...
systole answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, ... In the cardiac cycle, atrial systole precedes ventricular systole, which pumps blood into the aorta and pulmonary artery. ... In the cardiac cycle, atrial systole precedes ventricular systole, which pumps blood into the aorta and pulmonary artery. ... systole is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please sign in or purchase a ...
syrinx and systole is a book of prose poems and lyrical poems which meditate, with a Buddhist orientation, on philosophical and ...
... atrial systole explanation free. What is atrial systole? Meaning of atrial systole medical term. What does atrial systole mean? ... Looking for online definition of atrial systole in the Medical Dictionary? ... Related to atrial systole: atrial diastole, Ventricular systole systole. [sis´to-le] the contraction, or period of contraction ... extra systole see extrasystole.. ventricular systole contraction of the ventricles, forcing blood into the aorta and pulmonary ...
Exercise and physical activity help lower blood pressure by helping you lose weight and keep your heart and blood vessels in good shape. Weight loss achieved through diet and exercise helps to control factors such as glycemia and other complications of obesity. Avoiding these complications helps to lower blood pressure and prevent high blood pressure. Consult your doctor before starting a new exercise program.. * The NHS advises people to undertake 2 ½ hours of moderate physical activity each week or 1 hour and 15 minutes of vigorous exercise. If you are not yet very active, the British Heart Foundation recommends building your exercise level from a few 10-minute sessions each day. Overconsumption of alcohol over a long period has been found to contribute to higher levels of blood pressure. It can be easy for us not to know when we drink too much.. * Tip Frozen unsweetened peach slices are an excellent alternative to fresh peaches and nectarines in case of high blood pressure. Simply defrost in ...
Examples of a serving include a medium fruit, 1/2 cup of fresh, frozen or canned fruit, or 4 ounces of juice. Milk, yogurt, cheese and other dairy products are major sources of calcium, vitamin D and protein. But the key is to make sure that you choose low-fat or fat-free dairy products because otherwise they can be a major source of fat - and most are saturated. Examples of a serving include 1 cup of creamed milk or 1 percent of milk, 1 cup of milkow fatty yogurt, or 1 1/2 ounces of partially creamed cheese.. * With the exception of olive oil, coconut oil and sesame, I generally try to stay away from vehement oils tales. However, sesame seed oil has been popular in ancient medicines for millennia and possesses serious heart properties. Seed oil lowers blood pressure and helps protect against cardiac hypertrophy, a thickening of the heart muscle usually caused by high blood pressure. Much research is focused on the ability of sesame oil to increase potassium levels while decreasing sodium in the ...
Here we perform 3D tractography of the human heart \(in\) \(vivo\) at both end diastole and end systole. We show that fiber ... Diffusion MRI tractography of the human heart \(in\) \(vivo\) at end-diastole and end-systole. Journal of Cardiovascular ... Diffusion MRI Tractography of the Human Heart \(In\) \(Vivo\) at End-Diastole and End-Systole. ... decrease during systole. Our data suggest that myocardial fiber architecture is dynamic and is a function of both chamber ...
end-systole/systolic. ES-GLS. end-systolic global longitudinal strain. ES-SLS. end-systolic segmental longitudinal strain. ICC ... How to Define End-Diastole and End-Systole? Message Subject (Your Name) has forwarded a page to you from JACC: Cardiovascular ... Surrogate Parameters Used to Define End-Systole. (A) Mean error (considering the sign) ± SD; (B) mean absolute error (without ... 2009) A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign. Am J Physiol Heart ...
Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition ... Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition ...
Importance of Atrial Systole to Ventricular Filling Predicted by Transesophageal Echocardiography Steven N. Konstadt, M.D.; ... Importance of Atrial Systole to Ventricular Filling Predicted by Transesophageal Echocardiography You will receive an email ... Importance of Atrial Systole to Ventricular Filling Predicted by Transesophageal Echocardiography. Anesthesiology 6 1990, Vol. ... Steven N. Konstadt, David L. Reich, Daniel M. Thys, Zaharia Hillel, Eric Louie; Importance of Atrial Systole to Ventricular ...
Methods Thirty-five patients underwent 3D-perfusion CMR with data acquired at both end-systole and mid-diastole. MBF and ... Estimates of MBF are significantly different for systole and diastole at stress but diagnostic accuracy to detect CAD is high ... Methods Thirty-five patients underwent 3D-perfusion CMR with data acquired at both end-systole and mid-diastole. MBF and ... Estimates of MBF are significantly different for systole and diastole at stress but diagnostic accuracy to detect CAD is high ...
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of ... Download PDF Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in ... Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of ...
Atrial systole causes a substantial increase in myocardial segment length when the ventricle is on the sensitive part of its ... Left Ventricular Diastolic Pressure and Myocardial Segment Length and Observations on the Contribution of Atrial Systole. R. J ... Left Ventricular Diastolic Pressure and Myocardial Segment Length and Observations on the Contribution of Atrial Systole ... Left Ventricular Diastolic Pressure and Myocardial Segment Length and Observations on the Contribution of Atrial Systole ...
Define systole, diastole, and list the ranges of excellent,... ... List both the systole and. diastole. Define systole, diastole, ...
5 parts with Representation of Systole - 3B Smart Anatomy , Human Heart Models , Invest in quality with this uniquely sectioned ... Life-Size Human Heart Model, 5 parts with Representation of Systole - 3B Smart Anatomy. 239.19 € ... It shows the cardiac valves during diastole and on the base the valves are shown in systole. A dissection through the median ... Life-Size Human Heart Model, 5 parts with Representation of Systole - 3B Smart Anatomy. ...
Treatment Systole, premature. Symptoms and causes Systole, premature Prophylaxis Systole, premature ... premature systole - definition of premature systole in the .... premature systole n. See extrasystole . premature systole ... Premature systole , Define Premature systole at Dictionary.com. Medical Dictionary premature systole n. See extrasystole ... Premature systole - WrongDiagnosis.com. Premature systole information including symptoms, causes, diseases, symptoms, ...
Paired MBF plots for seven subjects comparing MBF obtained from gated and the self-gated systole dataset. Slices coded by color ... Fig7: Paired MBF plot (systole). a)-g) Paired MBF plots for seven subjects comparing MBF obtained from gated and the self-gated ... Fig7: Paired MBF plot (systole). a)-g) Paired MBF plots for seven subjects comparing MBF obtained from gated and the self-gated ... Results: Regional myocardial blood flow estimates (MBFs) obtained using self-gated systole (0.64 ± 0.26 ml/min/g), self-gated ...
  • The study of the asymptotic behavior for large genus g {\displaystyle g} of the systole of hyperbolic surfaces reveals some interesting constants. (wikipedia.org)
  • More details appear at systoles of surfaces. (wikipedia.org)