AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth Care
Systems BiologyBiologyComputational BiologyMetabolic Networks and PathwaysModels, BiologicalGene Regulatory NetworksSoftwareGenomicsProteomicsMolecular BiologyComputer SimulationAlgorithmsGene Expression ProfilingProteomeDevelopmental BiologyProtein Interaction MappingProgramming LanguagesMetabolomicsSystems IntegrationUser-Computer InterfaceSignal TransductionCell Physiological PhenomenaDatabases, GeneticDatabases, FactualComputer GraphicsProtein Interaction MapsSystems TheoryInternetDrug DiscoveryIndividualized MedicineOligonucleotide Array Sequence AnalysisDatabase Management SystemsBiochemical ProcessesMetabolomeTranscriptomeSynthetic BiologyBiological ProcessesModels, TheoreticalModels, GeneticCellsSystems AnalysisMetabolismInformation Storage and RetrievalBiotechnologyData MiningEngineeringBiochemistryBiological Science DisciplinesStochastic ProcessesDatabases, ProteinHigh-Throughput Screening AssaysGenomePhenotypeBiomedical ResearchPhysicsSaccharomyces cerevisiaeChronobiology PhenomenaMetabolic EngineeringCluster AnalysisGene Expression RegulationVirus Physiological ProcessesHost-Pathogen InteractionsBayes TheoremTranslational Medical ResearchNeoplasmsEnzymesProteinsFeedback, PhysiologicalDiseaseModels, StatisticalHistory, 21st CenturyBioengineeringMass SpectrometryNonlinear DynamicsCell Physiological ProcessesPhilosophyMolecular Sequence AnnotationMicroarray AnalysisWorkflowPlant Physiological PhenomenaToxicogeneticsGenetic EngineeringYeastsPhysiologyReproducibility of Results
Systems Biology
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
Biology
One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Metabolic Networks and Pathways
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Gene Regulatory Networks
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.
Software
Sequential operating programs and data which instruct the functioning of a digital computer.
Genomics
The systematic study of the complete DNA sequences (GENOME) of organisms.
Proteomics
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Molecular Biology
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
Computer Simulation
Computer-based representation of physical systems and phenomena such as chemical processes.
Algorithms
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Gene Expression Profiling
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Proteome
The protein complement of an organism coded for by its genome.
Developmental Biology
The field of biology which deals with the process of the growth and differentiation of an organism.
Protein Interaction Mapping
Methods for determining interaction between PROTEINS.
Programming Languages
Specific languages used to prepare computer programs.
Metabolomics
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
Systems Integration
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
User-Computer Interface
The portion of an interactive computer program that issues messages to and receives commands from a user.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cell Physiological Phenomena
Cellular processes, properties, and characteristics.
Databases, Genetic
Databases devoted to knowledge about specific genes and gene products.
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Computer Graphics
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Protein Interaction Maps
Graphs representing sets of measurable, non-covalent physical contacts with specific PROTEINS in living organisms or in cells.
Systems Theory
Principles, models, and laws that apply to complex interrelationships and interdependencies of sets of linked components which form a functioning whole, a system. Any system may be composed of components which are systems in their own right (sub-systems), such as several organs within an individual organism.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Drug Discovery
The process of finding chemicals for potential therapeutic use.
Individualized Medicine
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
Oligonucleotide Array Sequence Analysis
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Database Management Systems
Software designed to store, manipulate, manage, and control data for specific uses.
Biochemical Processes
Chemical reactions or functions, enzymatic activities, and metabolic pathways of living things.
Metabolome
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
Transcriptome
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Synthetic Biology
A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.
Biological Processes
Biological activities and function of the whole organism in human, animal, microorgansims, and plants, and of the biosphere.
Models, Theoretical
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Models, Genetic
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Cells
The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.
Systems Analysis
The analysis of an activity, procedure, method, technique, or business to determine what must be accomplished and how the necessary operations may best be accomplished.
Metabolism
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
Information Storage and Retrieval
Organized activities related to the storage, location, search, and retrieval of information.
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Data Mining
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
Engineering
The practical application of physical, mechanical, and mathematical principles. (Stedman, 25th ed)
Biochemistry
The study of the composition, chemical structures, and chemical reactions of living things.
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Stochastic Processes
Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.
Databases, Protein
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
High-Throughput Screening Assays
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
Genome
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Phenotype
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Biomedical Research
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Physics
The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Saccharomyces cerevisiae
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Chronobiology Phenomena
Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
Metabolic Engineering
Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.
Cluster Analysis
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Virus Physiological Processes
Biological activities of viruses and their interactions with the cells they infect.
Host-Pathogen Interactions
The interactions between a host and a pathogen, usually resulting in disease.
Bayes Theorem
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Translational Medical Research
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Enzymes
Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Feedback, Physiological
A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.
Disease
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
Models, Statistical
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
History, 21st Century
Time period from 2001 through 2100 of the common era.
Bioengineering
The application of engineering principles and methods to living organisms or biological systems.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Nonlinear Dynamics
The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.
Cell Physiological Processes
Cellular functions, mechanisms, and activities.
Philosophy
A love or pursuit of wisdom. A search for the underlying causes and principles of reality. (Webster, 3d ed)
Molecular Sequence Annotation
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Microarray Analysis
The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.
Workflow
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
Plant Physiological Phenomena
The physiological processes, properties, and states characteristic of plants.
Toxicogenetics
The study of existing genetic knowledge, and the generation of new genetic data, to understand and thus avoid DRUG TOXICITY and adverse effects from toxic substances from the environment.
Genetic Engineering
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
Yeasts
A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.
Physiology
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

Biological information: making it accessible and integrated (and trying to make sense of it). (1/2426)

The availability of the genome sequences of human and mouse, human sequence variation data and other large genetic data sets will lead to a revolution in understanding of the human machine and the treatment of its diseases. The success of the international genome sequencing consortiums shows what can be achieved by well coordinated large scale public domain projects and the benefits of data access to all. It is already clear that the availability of this sequence is having a huge impact on research worldwide. Complete genome sequences provide a framework to pull all biological data together such that each piece has the potential to say something about biology as a whole. Biology is too complex for any organisation to have a monopoly of ideas or data, so the collection, analysis and access to this data can be contributed to by research institutes around the world. However, although it is possible for all this data to be accessible to all through the internet, the more organisations provide data or analysis separately, the harder it becomes for anyone to collect and integrate the results. To address these problems of intergration of data, open standards for biological data exchange, such as the 'Distributed Annotation System' (DAS) are being developed and bioinformatics (Dowell et al., 2001) as a whole is now being strongly driven by the open source software (OSS) model for collaborative software development (Hubbard and Birney, 1999). The leading provider of human genome annotation, the Ensembl project (http://www.ensembl.org), is entirely an OSS project and has been widely adopted by academic and commerical organisations alike (Hubbard et al., 2002). Accurate automatic annotation of features such as genes in vertebrate genomes currently relies on supporting evidence in the form of homologies to mRNAs, ESTs or protein. However, it appears that sufficient high quality experimentally curated annotation now exists to be used as a substrate for machine learning algorithms to create effective models of biological signal sequences (Down and Hubbard, 2002). Is there hope for ab initio prediction methods after all?  (+info)

CEBS object model for systems biology data, SysBio-OM. (2/2426)

MOTIVATION: To promote a systems biology approach to understanding the biological effects of environmental stressors, the Chemical Effects in Biological Systems (CEBS) knowledge base is being developed to house data from multiple complex data streams in a systems friendly manner that will accommodate extensive querying from users. Unified data representation via a single object model will greatly aid in integrating data storage and management, and facilitate reuse of software to analyze and display data resulting from diverse differential expression or differential profile technologies. Data streams include, but are not limited to, gene expression analysis (transcriptomics), protein expression and protein-protein interaction analysis (proteomics) and changes in low molecular weight metabolite levels (metabolomics). RESULTS: To enable the integration of microarray gene expression, proteomics and metabolomics data in the CEBS system, we designed an object model, Systems Biology Object Model (SysBio-OM). The model is comprehensive and leverages other open source efforts, namely the MicroArray Gene Expression Object Model (MAGE-OM) and the Proteomics Experiment Data Repository (PEDRo) object model. SysBio-OM is designed by extending MAGE-OM to represent protein expression data elements (including those from PEDRo), protein-protein interaction and metabolomics data. SysBio-OM promotes the standardization of data representation and data quality by facilitating the capture of the minimum annotation required for an experiment. Such standardization refines the accuracy of data mining and interpretation. The open source SysBio-OM model, which can be implemented on varied computing platforms is presented here. AVAILABILITY: A universal modeling language depiction of the entire SysBio-OM is available at http://cebs.niehs.nih.gov/SysBioOM/. The Rational Rose object model package is distributed under an open source license that permits unrestricted academic and commercial use and is available at http://cebs.niehs.nih.gov/cebsdownloads. The database and interface are being built to implement the model and will be available for public use at http://cebs.niehs.nih.gov.  (+info)

MathSBML: a package for manipulating SBML-based biological models. (3/2426)

MathSBML is a Mathematica package designed for manipulating Systems Biology Markup Language (SBML) models. It converts SBML models into Mathematica data structures and provides a platform for manipulating and evaluating these models. Once a model is read by MathSBML, it is fully compatible with standard Mathematica functions such as NDSolve (a differential-algebraic equations solver). MathSBML also provides an application programming interface for viewing, manipulating, running numerical simulations; exporting SBML models; and converting SBML models in to other formats, such as XPP, HTML and FORTRAN. By accessing the full breadth of Mathematica functionality, MathSBML is fully extensible to SBML models of any size or complexity. AVAILABILITY: Open Source (LGPL) at http://www.sbml.org and http://www.sf.net/projects/sbml  (+info)

CSB.DB: a comprehensive systems-biology database. (4/2426)

SUMMARY: The open access comprehensive systems-biology database (CSB.DB) presents the results of bio-statistical analyses on gene expression data in association with additional biochemical and physiological knowledge. The main aim of this database platform is to provide tools that support insight into life's complexity pyramid with a special focus on the integration of data from transcript and metabolite profiling experiments. The central part of CSB.DB, which we describe in this applications note, is a set of co-response databases that currently focus on the three key model organisms, Escherichia coli, Saccharomyces cerevisiae and Arabidopsis thaliana. CSB.DB gives easy access to the results of large-scale co-response analyses, which are currently based exclusively on the publicly available compendia of transcript profiles. By scanning for the best co-responses among changing transcript levels, CSB.DB allows to infer hypotheses on the functional interaction of genes. These hypotheses are novel and not accessible through analysis of sequence homology. The database enables the search for pairs of genes and larger units of genes, which are under common transcriptional control. In addition, statistical tools are offered to the user, which allow validation and comparison of those co-responses that were discovered by gene queries performed on the currently available set of pre-selectable datasets. AVAILABILITY: All co-response databases can be accessed through the CSB.DB Web server (http://csbdb.mpimp-golm.mpg.de/).  (+info)

Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1. (5/2426)

BACKGROUND: Large fractions of all fully sequenced genomes code for proteins of unknown function. Annotating these proteins of unknown function remains a critical bottleneck for systems biology and is crucial to understanding the biological relevance of genome-wide changes in mRNA and protein expression, protein-protein and protein-DNA interactions. The work reported here demonstrates that de novo structure prediction is now a viable option for providing general function information for many proteins of unknown function. RESULTS: We have used Rosetta de novo structure prediction to predict three-dimensional structures for 1,185 proteins and protein domains (<150 residues in length) found in Halobacterium NRC-1, a widely studied halophilic archaeon. Predicted structures were searched against the Protein Data Bank to identify fold similarities and extrapolate putative functions. They were analyzed in the context of a predicted association network composed of several sources of functional associations such as: predicted protein interactions, predicted operons, phylogenetic profile similarity and domain fusion. To illustrate this approach, we highlight three cases where our combined procedure has provided novel insights into our understanding of chemotaxis, possible prophage remnants in Halobacterium NRC-1 and archaeal transcriptional regulators. CONCLUSIONS: Simultaneous analysis of the association network, coordinated mRNA level changes in microarray experiments and genome-wide structure prediction has allowed us to glean significant biological insights into the roles of several Halobacterium NRC-1 proteins of previously unknown function, and significantly reduce the number of proteins encoded in the genome of this haloarchaeon for which no annotation is available.  (+info)

System-based proteomic analysis of the interferon response in human liver cells. (6/2426)

BACKGROUND: Interferons (IFNs) play a critical role in the host antiviral defense and are an essential component of current therapies against hepatitis C virus (HCV), a major cause of liver disease worldwide. To examine liver-specific responses to IFN and begin to elucidate the mechanisms of IFN inhibition of virus replication, we performed a global quantitative proteomic analysis in a human hepatoma cell line (Huh7) in the presence and absence of IFN treatment using the isotope-coded affinity tag (ICAT) method and tandem mass spectrometry (MS/MS). RESULTS: In three subcellular fractions from the Huh7 cells treated with IFN (400 IU/ml, 16 h) or mock-treated, we identified more than 1,364 proteins at a threshold that corresponds to less than 5% false-positive error rate. Among these, 54 were induced by IFN and 24 were repressed by more than two-fold, respectively. These IFN-regulated proteins represented multiple cellular functions including antiviral defense, immune response, cell metabolism, signal transduction, cell growth and cellular organization. To analyze this proteomics dataset, we utilized several systems-biology data-mining tools, including Gene Ontology via the GoMiner program and the Cytoscape bioinformatics platform. CONCLUSIONS: Integration of the quantitative proteomics with global protein interaction data using the Cytoscape platform led to the identification of several novel and liver-specific key regulatory components of the IFN response, which may be important in regulating the interplay between HCV, interferon and the host response to virus infection.  (+info)

Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis. (7/2426)

The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks.  (+info)

Modelling the dynamics of biosystems. (8/2426)

The need for a more formal handling of biological information processing with stochastic and mobile process algebras is addressed. Biology can benefit this approach, yielding a better understanding of behavioural properties of cells, and computer science can benefit this approach, obtaining new computational models inspired by nature.  (+info)

Cancer systems biology - WikipediaCancer systems biology - Wikipedia
Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. Cancer systems biology represents the application of systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis to develop effective predictive models that can assist scientists and clinicians in the validations of new therapies and drugs. Tumours are characterized by genomic and epigenetic instability that alters the functions of many different molecules and networks in a single cell as well as altering the interactions with the local environment. Cancer systems biology approaches, therefore, are based on the use of computational and mathematical methods to decipher the complexity in tumorigenesis as well as cancer heterogeneity. Cancer systems biology encompasses concrete applications of systems biology ...
https://en.wikipedia.org/wiki/Cancer_systems_biology
Computational Systems Biology: German/Russian Network of Computational Systems Biology
Hofestädt, R., and Kolchanov, N. eds. (2010). Computational Systems Biology: German/Russian Network of Computational Systems Biology. Medizinische Informatik und Bioinformatik ...
https://pub.uni-bielefeld.de/publication/2376605
Systems Biology of Apoptosis - beck-shop.deSystems Biology of Apoptosis - beck-shop.de
Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies ...
http://m.beck-shop.de/item/3130343934313432
Institute for Integrative Systems Biology (IBIS), UL, Canada | Institution outputs | Nature IndexInstitute for Integrative Systems Biology (IBIS), UL, Canada | Institution outputs | Nature Index
Research outputs, collaborations and relationships for Institute for Integrative Systems Biology (IBIS), UL published between 1 July 2019 - 30 June 2020 as tracked by the Nature Index.
https://www.natureindex.com/institution-outputs/canada/institute-for-integrative-systems-biology-ibis-ul/56f89e7e140ba0a7098b4585/Life%20Sciences
Integrative radiation systems biology | Radiation Oncology | Full TextIntegrative radiation systems biology | Radiation Oncology | Full Text
The term systems biology is now widely used and there is not one common definition of it. In reality, there are uncountable ways of understanding, explaining and applying systems biology. Concepts as represented in review articles by Hornberg et al. [7] or Bruggeman and Westerhoff [8] nicely describe what could be considered as common understanding of systems biology. In order to make clear how I understand systems biology I suggest one definition of systems biology as follows:. While traditional, reductionistic approaches investigated the property of one or of a few components (i.e. molecules) or their interaction with one or a few other molecules at the time, systems biology investigates the emergent properties of the system under investigation (e.g. organelles, cells, organs, organisms or eco systems) when multiple entities interact in networks. To do so, systems biology requires highly interdisciplinary approaches involving expertise from physics, mathematics, graph network theory and ...
https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-9-21
Aging and Health - A Systems Biology Perspective - Karger PublishersAging and Health - A Systems Biology Perspective - Karger Publishers
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its ...
https://content.karger.com/Book/Home/261901
Journal of Computational Systems Biology | Open Access Journal | Annex PublishersJournal of Computational Systems Biology | Open Access Journal | Annex Publishers
Journal of Computational Systems Biology (JCSB) is an open access online journal which aims to publish peer reviewed research articles and short communications in all aspects of computational biology and bioinformatics. JCSB comprehend the broad spectrum of computational bioscience including biological databases and bioalgorithms.
http://www.annexpublishing.org/journals/journal-of-computational-systems-biology/jhome.php
Download Computational Systems Biology Inference And Modelling 2016
2013) Delivering intellectual physical download computational systems biology inference and modelling 2016 in Russian events: a weight mass of Scottish Natural Heritage National Nature Reserves. International Research in Geographical and Environmental Education, multiperiod), 4-22. The Canadian Environmental Literacy Project( CELP).
http://rtia.co.za/ruploads/library.php?q=download-computational-systems-biology-inference-and-modelling-2016/
Computational Systems Biology. Lecture 2: Enzymes - PDF Free DownloadComputational Systems Biology. Lecture 2: Enzymes - PDF Free Download
Computational Systems Biology Lecture 2: Enzymes 1 Images from: David L. Nelson, Lehninger Principles of Biochemistry, IV Edition, Freeman ed. or under creative commons license (search for images at
http://docplayer.net/8054787-Computational-systems-biology-lecture-2-enzymes.html
A systems biology perspective on the role of WRKY transcription factors in drought responses in plants | SpringerLinkA systems biology perspective on the role of WRKY transcription factors in drought responses in plants | SpringerLink
Information regarding the different downstream target genes of WRKY TFs that regulate abiotic stress-induced responses is limited. Advances have, however, been made in a dehydration tolerance signaling pathway in the resurrection plant Boea hygrometrica (Wang et al. 2009). An important downstream target gene, Galactinol synthase 1 (BhGolS1), which plays a role in drought and cold tolerance (Teruaki et al. 2002) was found to be dehydration and ABA inducible. The BhGolS1 promoter contains four W boxes and chromatin immunoprecipitation showed that it is bound in vivo by the early dehydration and ABA-inducible BhWRKY1 TF (Wang et al. 2009). These observations provide direct insights into the role of a dehydration-inducible WRKY TF that interacts with a downstream target gene that plays an important role in drought responses. Recently, convincing evidence has been presented to show that AtWRKY8 functions antagonistically with its interacting partner VQ9 to modulate salinity tolerance (Hu et al. ...
https://link.springer.com/article/10.1007/s00425-013-1985-y
Systems biology perspectives on calcium signaling and DNA repairSystems biology perspectives on calcium signaling and DNA repair
The first part of this thesis focuses on the mechanisms of hormone induced Ca2+ oscillations and how these depend on fluctuations in the concentration of the Ca2+-releasing messenger, inositol 1,4,5-trisphosphate (IP3). We were able to show that IP3 oscillations greatly enhances the ability to frequency encode the hormone stimulus by Ca2+ oscillations. Two mechanisms for the generation of IP3-oscillations have been investigated, we could show that Ca2+-activation of phospholipase C is the most probable mechanism. To better understand the role of IP3-oscillations a detailed model for the phosphoinositide pathway has been developed. The model illustrates the importance of futile (de)phosphorylation cycles for regenerating phosphatidylinositol-4,5-bisphophat during stimulation, an essential property to support long-lasting Ca2+ signals. The second part of the thesis is devoted to nucleotide excision repair (NER). It is a versatile DNA repair mechanism that can remove lesions such as UV light ...
https://edoc.hu-berlin.de/handle/18452/16382
Metabolomics for Investigating Disease Process
NMR spectroscopy is widely regarded as a technique that is unbiased, non-invasive and requires minimal sample preparation. These characteristics make this technique an ideal one to monitor the biological systems. In addition, NMR spectroscopy can also provide global snapshot and dynamics of complex biological systems such as cell, tissue or even an organism. This finds utility in the recently developed systems biological approaches that take holistic view of the complex biological networks rather than the conventional reductionism. Within the Biochemistry and Systems Biology group, Our lab focuses on one such complex problem that is the host-parasite interaction during infection by malarial parasite. Malaria is considered to be one of the major killers in large part of the world. We believe, systems biological approaches may provide us specific insights to the mechanism of disease progression, since this involves the joint biological network of host and the parasite. Therefore, understanding the ...
http://www.tifr.res.in/~dcs/index.php?option=com_content&view=article&id=71&Itemid=173
Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge...
TY - JOUR. T1 - Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with mycobacterium bovis. AU - Magee, David A.. AU - Taraktsoglou, Maria. AU - Killick, Kate E.. AU - Nalpas, Nicolas C.. AU - Browne, John A.. AU - Park, Stephen D.E.. AU - Conlon, Kevin M.. AU - Lynn, David. AU - Hokamp, Karsten. AU - Gordon, Stephen V.. AU - Gormley, Eamonn. AU - MacHugh, David E.. PY - 2012/2/22. Y1 - 2012/2/22. N2 - Background: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome of infection. Here, a functional genomics approach was undertaken to investigate global gene expression profiles in bovine monocyte-derived macrophages (MDM) purified from seven age-matched non-related females, in response to in ...
https://portal.sahmriresearch.org/en/publications/global-gene-expression-and-systems-biology-analysis-of-bovine-mon
A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary...A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary...
Dietary methionine restriction (MR) and calorie restriction (CR) each improve metabolic health and extend life span. We used comprehensive transcriptome profiling and systems biology analysis to interrogate the unique and overlapping molecular responses in rats provided these dietary regimens for 20 mo after weaning. Microarray analysis was conducted on inguinal white adipose (IWAT), brown adipose tissue (BAT), liver, and skeletal muscle. Compared to controls, CR-induced transcriptomic responses (absolute fold change ≥1.5 and P≤0.05) were comparable in IWAT, BAT, and liver (~800 genes). MR-induced effects were largely restricted to IWAT and liver (~2400 genes). Pathway enrichment and gene-coexpression analyses showed that induction of fatty acid synthesis in IWAT was common to CR and MR, whereas immunity and proinflammatory signaling pathways were specifically down-regulated in MR-treated IWAT and liver (FDR≤0.07-0.3). BAT demonstrated consistent down-regulation of PPAR-signaling under CR ...
https://www.pubfacts.com/detail/24571921/A-systems-biology-analysis-of-the-unique-and-overlapping-transcriptional-responses-to-caloric-restri
A systems biology approach reveals common metastatic pathways in osteosarcoma | BMC Systems Biology | Full TextA systems biology approach reveals common metastatic pathways in osteosarcoma | BMC Systems Biology | Full Text
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. The survival rate of patients with metastatic disease remains very dismal. Nevertheless, metastasis is a complex process and a single-level analysis is not likely to identify its key biological determinants. In this study, we used a systems biology approach to identify common metastatic pathways that are jointly supported by both mRNA and protein expression data in two distinct human metastatic OS models. mRNA expression microarray and N-linked glycoproteomic analyses were performed on two commonly used isogenic pairs of human metastatic OS cell lines, namely HOS/143B and SaOS-2/LM7. Pathway analysis of the differentially regulated genes and glycoproteins separately revealed pathways associated to metastasis including cell cycle regulation, immune response, and epithelial-to-mesenchymal-transition. However, no common significant pathway was found at both genomic and proteomic levels between the two metastatic models,
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-6-50
A systems biology approach to identify effective cocktail drugs | BMC Systems Biology | Full TextA systems biology approach to identify effective cocktail drugs | BMC Systems Biology | Full Text
Complex diseases, such as Type 2 Diabetes, are generally caused by multiple factors, which hamper effective drug discovery. To combat these diseases, combination regimens or combination drugs provide an alternative way, and are becoming the standard of treatment for complex diseases. However, most of existing combination drugs are developed based on clinical experience or test-and-trial strategy, which are not only time consuming but also expensive. In this paper, we presented a novel network-based systems biology approach to identify effective drug combinations by exploiting high throughput data. We assumed that a subnetwork or pathway will be affected in the networked cellular system after a drug is administrated. Therefore, the affected subnetwork can be used to assess the drugs overall effect, and thereby help to identify effective drug combinations by comparing the subnetworks affected by individual drugs with that by the combination drug. In this work, we first constructed a molecular interaction
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-S2-S7
A systems biology model of the regulatory network in Populus leaves reveals interacting regulators and conserved regulationA systems biology model of the regulatory network in Populus leaves reveals interacting regulators and conserved regulation
We outline a computationally inferred model of the regulatory network of Populus leaves, and show how treating genes as interacting, rather than individual, entities identifies new regulators compared to traditional genomics analysis. Although systems biology models should be used with care considering the complexity of regulatory programs and the limitations of current genomics data, methods describing interactions can provide hypotheses about the underlying cause of emergent properties and are needed if we are to identify target genes other than those constituting the low hanging fruit of genomic analysis.. ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:409959&language=sv
npj Systems Biology and Applicationsnpj Systems Biology and Applications
npj Systems Biology and Applications is a new open-access, online only multi- and interdisciplinary journal dedicated to publishing the finest research on the Systems Biology and related research to that System Biological approach is applied.
http://www.nature.com/npjsba/?error=cookies_not_supported&code=006fcf5d-c492-4e3d-b55a-0dd9d7039674
npj Systems Biology and Applicationsnpj Systems Biology and Applications
npj Systems Biology and Applications is a new open-access, online only multi- and interdisciplinary journal dedicated to publishing the finest research on the Systems Biology and related research to that System Biological approach is applied.
http://www.nature.com/npjsba/?error=cookies_not_supported&code=4abc74f4-d105-44ba-b9f6-6c048a9acb1f
Manchester Centre for Integrative Systems BiologyManchester Centre for Integrative Systems Biology
Current research interests: Metabolomics. Ricks research goals focus on the systems biology investigations of microbial and mammalian systems, specifically the application of metabolomics to these disciplines and the development of analytical instrumentation and methodologies to fulfill these goals. Metabolomics is focussed on the holistic and data-driven investigation of the quantitative collection of low molecular weight organic and inorganic compounds present in biological systems. This collection of endogenous and exogenous metabolites is defined as the metabolome. Endogenous metabolites can be biochemically synthesized or catabolised within the system and exogenous metabolites are acquired from the external environment (for example, food nutrients and drugs) or from co-habiting species (for example, gut microbiome). A range of experimental strategies are employed to investigate the metabolome including metabolic profiling (untargeted analysis), targeted analysis and metabolite ...
http://www.mcisb.org/people/dunn/
Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering | BMC...Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering | BMC...
Mechanistic models are becoming more and more popular in Systems Biology; identification and control of models underlying biochemical pathways of interest in oncology is a primary goal in this field. Unfortunately the scarce availability of data still limits our understanding of the intrinsic characteristics of complex pathologies like cancer: acquiring information for a system understanding of complex reaction networks is time consuming and expensive. Stimulus response experiments (SRE) have been used to gain a deeper insight into the details of biochemical mechanisms underlying cell life and functioning. Optimisation of the input time-profile, however, still remains a major area of research due to the complexity of the problem and its relevance for the task of information retrieval in systems biology-related experiments. We have addressed the problem of quantifying the information associated to an experiment using the Fisher Information Matrix and we have proposed an optimal experimental design
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-10-S12-S4
Andreas Dräger | Systems Biology Research Group
Ali Ebrahim, Eivind Almaas, Eugen Bauer, Aarash Bordbar, Anthony P. Burgard, Roger L. Chang, Andreas Dräger, Iman Famili, Adam M. Feist, Ronan M. T. Fleming, Stephen S. Fong, Vassily Hatzimanikatis, Markus J. Herrgard, Allen Holder, Michael Hucka, Daniel Hyduke, Neema Jamshidi, Sang Yup Lee, Nicolas Le Novère, Joshua A. Lerman, Nathan E. Lewis, Ding Ma, Radhakrishnan Mahadevan, Costas Maranas, Harish Nagarajan, Ali Navid, Jens Nielsen, Lars K. Nielsen, Juan Nogales, Alberto Noronha, Csaba Pal, Bernhard O. Palsson, Jason A. Papin, Kiran R. Patil, Nathan D. Price, Jennifer L. Reed, Michael Saunders, Ryan S. Senger, Nikolaus Sonnenschein, Yuekai Sun, and Ines Thiele. Do Genome-scale Models Need Exact Solvers or Clearer Standards? Molecular Systems Biology, 11(10), October 2015. [ DOI , link , pdf ...
http://sbrg.ucsd.edu/Researchers/Draeger
M barkeri | Systems Biology Research Group
There has been one iteration of the M. barkeri reconstruction and model published in Molecular Systems Biology in early 2006.. We have the following information available:. ...
http://sbrg.ucsd.edu/InSilicoOrganisms/Mbarkeri
In Silico Systems Pharmacology to Assess Drugs Therapeutic and Toxic Effects | Bentham ScienceIn Silico Systems Pharmacology to Assess Drugs Therapeutic and Toxic Effects | Bentham Science
Title:In Silico Systems Pharmacology to Assess Drugs Therapeutic and Toxic Effects. VOLUME: 22 ISSUE: 46. Author(s):Alejandro Aguayo-Orozco, Karine Audouze, Soren Brunak and Olivier Taboureau. Affiliation:Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen. Keywords:Systems pharmacology, biological network, drug, protein-protein interactions, pathways, gene expression, pharmacogenomics, toxicity.. Abstract:For many years, the one target, one drug paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward drug-holistic systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. ...
https://www.eurekaselect.com/145415/article
Systems Biology: Neurobiology | The Canadian Society for Systems Biology
Systems Biology: Neurobiology - University of Toronto. The new Department of Cell and Systems Biology at the University of Toronto invites applications for a tenure track faculty position to be appointed at the Assistant Professor level in the field of Systems Biology - Neurobiology to begin July 1, 2008.. We particularly encourage candidates to apply who have demonstrated excellence in addressing fundamental questions in neurobiology using high-throughput approaches or gene/protein network analyses with bioinformatics, genomic, proteomic, electrophysiological, or imaging tools. Our vision is to advance Systems-wide analyses in Neurobiology which complement existing strengths in the department (www.csb.utoronto.ca).. Candidates should have at least two years of research experience beyond their doctoral degree. In addition to pursuing a vigorous, internationally recognized research program, the successful candidate will contribute to undergraduate and graduate teaching in the molecular life ...
http://sysbiosociety.ca/jobs/systems-biology-neurobiology
A systems biology study of alternative splicing regulations and functions - UBC Library Open CollectionsA systems biology study of alternative splicing regulations and functions - UBC Library Open Collections
Learning, knowledge, research, insight: welcome to the world of UBC Library, the second-largest academic research library in Canada.
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0348261
A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana | EURASIP Journal on Bioinformatics...A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana | EURASIP Journal on Bioinformatics...
Plant carbohydrate metabolism comprises numerous metabolite interconversions, some of which form cycles of metabolite degradation and re-synthesis and are thus referred to as futile cycles. In this study, we present a systems biology approach to analyse any possible regulatory principle that operates such futile cycles based on experimental data for sucrose (Scr) cycling in photosynthetically active leaves of the model plant Arabidopsis thaliana. Kinetic parameters of enzymatic steps in Scr cycling were identified by fitting model simulations to experimental data. A statistical analysis of the kinetic parameters and calculated flux rates allowed for estimation of the variability and supported the predictability of the model. A principal component analysis of the parameter results revealed the identifiability of the model parameters. We investigated the stability properties of Scr cycling and found that feedback inhibition of enzymes catalysing metabolite interconversions at different steps of the cycle
https://bsb-eurasipjournals.springeropen.com/articles/10.1186/1687-4153-2011-2/figures/9
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in...The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in...
Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder, intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated, resulting in a large number of molecular clues, it has proven difficult to generate specific hypotheses without the cor …
https://pubmed.ncbi.nlm.nih.gov/30053424/
Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological...Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological...
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers,including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expression profile using high-throughput miRNA array followed by in-depth systems biological analyses. Total RNA was isolated from 34 GC patients and 15 normal controls and hybridised and differentially expressed miRNAs in GC compared to normal controls were analysed. A total of 250 miRNAs were found to be differentially expressed in GC with a fold change ranging from + 2.5984 to – 3.5271 compared to normal gastric tissues. The differentially expressed miRNAs were further subjected to Ingenuity Pathway Analysis to understand the modulation of cellular and molecular functions and associated physiological system development and functions in GC. The Oncomirs such as miR-155-5p, miR-17
https://www.geneticsmr.com/articles/decrypting-microrna-signatures-gastric
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach. - Oxford Neuroscience
The sodium-potassium pump is widely recognized as the principal mechanism for active ion transport across the cellular membrane of cardiac tissue, being responsible for the creation and maintenance of the transarcolemmal sodium and potassium gradients, crucial for cardiac cell electrophysiology. Importantly, sodium-potassium pump activity is impaired in a number of major diseased conditions, including ischemia and heart failure. However, its subtle ways of action on cardiac electrophysiology, both directly through its electrogenic nature and indirectly via the regulation of cell homeostasis, make it hard to predict the electrophysiological consequences of reduced sodium-potassium pump activity in cardiac repolarization. In this review, we discuss how recent studies adopting the systems biology approach, through the integration of experimental and modeling methodologies, have identified the sodium-potassium pump as one of the most important ionic mechanisms in regulating key properties of cardiac
https://www.neuroscience.ox.ac.uk/publications/401270
Investigating cholesterol metabolism and ageing using a systems biology approach<...Investigating cholesterol metabolism and ageing using a systems biology approach<...
TY - JOUR. T1 - Investigating cholesterol metabolism and ageing using a systems biology approach. AU - Morgan, A.E.. AU - Mooney, Kathleen. AU - Wilkinson, S. J.. AU - Pickles, N.A.. PY - 2016/11/2. Y1 - 2016/11/2. N2 - CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age respectively in 2011. The dysregulation of cholesterol metabolism with age, often observed as a rise in LDL-chol- esterol, has been associated with the pathogenesis of CVD. To compound this problem, it is estimated by 2050, 22 % of the worlds population will be over 60 years of age, in culmin- ation with a growing resistance and intolerance to pre-existing cholesterol regulating drugs such as statins. Therefore, it is apparent research into additional therapies for hypercholes- terolaemia and CVD prevention is a growing necessity. ...
https://research.edgehill.ac.uk/en/publications/investigating-cholesterol-metabolism-and-ageing-using-a-systems-b-2
RFA-AG-17-057: Systems Biology Approaches to Alzheimers Disease Using Non-mammalian Laboratory Animals (R01)RFA-AG-17-057: Systems Biology Approaches to Alzheimers Disease Using Non-mammalian Laboratory Animals (R01)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Systems Biology Approaches to Alzheimers Disease Using Non-mammalian Laboratory Animals (R01) RFA-AG-17-057. NIA
https://grants.nih.gov/grants/guide/rfa-files/RFA-Ag-17-057.html
Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD - Fingerprint - Mayo...
Fingerprint Dive into the research topics of Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD. Together they form a unique fingerprint. ...
https://mayoclinic.pure.elsevier.com/en/publications/divergence-convergence-and-therapeutic-implications-a-cell-biolog/fingerprints/
Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. | Systems Biology Research...
Growth is a fundamental process of life. Growth requirements are well-characterized experimentally for many microbes; however, we lack a unified model for cellular growth. Such a model must be predictive of events at the molecular scale and capable of explaining the high-level behavior of the cell as a whole. Here, we construct an ME-Model for Escherichia coli-a genome-scale model that seamlessly integrates metabolic and gene product expression pathways. The model computes ∼80% of the functional proteome (by mass), which is used by the cell to support growth under a given condition. Metabolism and gene expression are interdependent processes that affect and constrain each other. We formalize these constraints and apply the principle of growth optimization to enable the accurate prediction of multi-scale phenotypes, ranging from coarse-grained (growth rate, nutrient uptake, by-product secretion) to fine-grained (metabolic fluxes, gene expression levels). Our results unify many existing ...
http://systemsbiology.ucsd.edu/node/880
Computational Systems BiologyComputational Systems Biology
All biological interactions, whether they take place on a molecular, organism or ecosystem scale, are part of complex dynamical systems. Understanding the behaviour of these systems lies at the heart of many key challenges in biological research. In this module you will have the opportunity to develop and investigate mathematical models of biological systems. You will learn techniques to construct, implement and analyse interaction networks using the Python programming language. Research in the field of Systems Biology is highly interdisciplinary. It often involves biologists working with colleagues from the fields of physics, engineering, mathematics and computer science. Consequently this module encourages participation from any interested science or engineering student. ...
http://www.ucl.ac.uk/prospective-students/study-abroad-ucl/summer-school/modules/computational-systems-biology
Course Catalogue - Computational Systems Biology (INFR11039)
Systems Biology is the application of computational modelling and simulation to complex systems in biology. Examples include biochemical pathways, metabolic processes, protein complexes and information processing, genetic networks, self-organising systems, neuronal networks and cell-cell communication. This course will focus on the level of molecular and genetic systems and simulations ...
http://www.drps.ed.ac.uk/11-12/dpt/cxinfr11039.htm
Manchester Centre for Integrative Systems BiologyManchester Centre for Integrative Systems Biology
Linux For Linux, its zip file should be extracted into your $HOME/.taverna-1.6.2/lib folder. Your Taverna runme.sh script should then be edited with the text highlighted in bold as follows: (..) # Load customised properties if they exist if [ -f $TAVERNA_HOME/custom.sh ] ; then source $TAVERNA_HOME/custom.sh fi #Set to $TAVERNA_HOME/lib for shared installation LIB_PATH=$HOME/.taverna-1.6.2/lib LD_LIBRARY_PATH=$LIB_PATH export LD_LIBRARY_PATH ARGS=-Djava.library.path=$LIB_PATH java $ARGS -jar $TAVERNA_HOME/taverna-bootstrap-1.6.2.0.jar [email protected] MacOS X For those people using MacOS X, the libsbml native libraries should be placed in the same directory where your Taverna application bundle resides. So for example, if your Taverna application bundle is in /Applications/Taverna-1.6.2/Taverna.app then the libxerces-c.27.dylib, libsbml.dylib and libsbmlj.jnilib files should be placed there. In constrast, the libsbml jar file should be placed in Tavernas lib folder which is found at ...
http://www.mcisb.org/resources/taverna/libsbml/index.html
Courtney G. Woods, PhD - UNC Gillings School of Global Public HealthCourtney G. Woods, PhD - UNC Gillings School of Global Public Health
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Melvin Andersen, M Andersen, Sudin Bhattacharya, S Bhattacharya, Brett Howell, B Howell, Patrick McMullen, P McMullen, Lisl Shoda, L Shoda, Scott Siler, S Siler, Paul Watkins, P Watkins, Jeffrey Woodhead, J Woodhead, Courtney Woods, C Woods, Yuching Yang, Y Yang, Qiang Zhang, Q Zhang (2012). Frontiers in Physiology, 3.. Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: Involvement of cellular adaptive response to oxidative stress. Melvin Andersen, Sheila Collins, Jingqi Fu, Jingbo Pi, Guifan Sun, Victoria Wong, Courtney Woods, Einav Yehuda-Shnaidman, Qiang Zhang (2010). Environmental Health Perspectives, 118(6), 864-870.. A systems biology perspective on Nrf2-mediated antioxidant response. Melvin Andersen, Jingbo Pi, Courtney Woods, Qiang Zhang (2010). Toxicology and Applied Pharmacology, 244(1), 84-97.. Dose-dependent transitions in Nrf2-mediated adaptive response and ...
https://sph.unc.edu/adv_profile/courtney-g-woods/
Alexander Sorkin, Ph.D. | Integrative Systems Biology | University of PittsburghAlexander Sorkin, Ph.D. | Integrative Systems Biology | University of Pittsburgh
The main focus of the research in the laboratory is currently split into two major directions which are apparently distinct from each other with respect to the biological systems involved, their relation to the human disease, and experimental models used. However, the main idea underlying both directions is conceptually the same - to understand how endocytosis and post-endocytic trafficking regulates function(s) of the transmembrane proteins, such as receptors and transporters. In particular, we aim at elucidating the molecular mechanisms of endocytosis of growth factor receptors using a prototypic member of the family, epidermal growth factor (EGF) receptor, and analysis of the role of endocytosis in spatial and temporal regulation of signal transduction by the EGF receptor. In the second direction, we would like to elucidate the role of trafficking processes in the regulation of dopaminergic neurotransmission by the plasma membrane dopamine transporter (DAT). By understanding how DAT activity ...
https://www.isb.pitt.edu/people/faculty/alexander-sorkin-phd
Alan Wells, D.M.Sc., M.D. | Integrative Systems Biology | University of PittsburghAlan Wells, D.M.Sc., M.D. | Integrative Systems Biology | University of Pittsburgh
Within his laboratory, Dr. Wells and his research team are aiming to gain a better understanding of cells respond to their local environment. Due to the widespread implications of such research, Dr. Wells has been featured in several publications. Ultimately, the importance of his research flows from the provision of reinforcing insights and novel avenues for exploration into the basic signaling pathways, as well as functioning of entire organisms. Currently, Dr. Wells is concentrating his research efforts towards gaining further knowledge of the conditions of dysregulated (tumor dissemination and chemoresistance of tumors) and orchestrated (wound healing and organogenesis) responses.. ...
https://www.isb.pitt.edu/people/faculty/alan-wells-dmsc-md
NIH Funds Cilia Motility Study | Integrative Systems Biology | University of PittsburghNIH Funds Cilia Motility Study | Integrative Systems Biology | University of Pittsburgh
Congratulations to Dr. Cecilia Lo and Dr. Michael Tsang on their recently funded NIH administrative supplement, Assaying Heterotaxy Patient Genes in a Cilia Motility and Left-Right Patterning. This project will examine whether expression of the RCV can rescue the HTX phenotype elicited by MO gene knockdown in the zebrafish embryo.
https://pimb.pitt.edu/news/nih-funds-cilia-motility-study
Computational and Systems Biology of CancerComputational and Systems Biology of Cancer
Prepare for the conference with access to impactful genomics and systems biology articles, published across the AACR journals.. The field of cancer systems biology has emerged to address the increasing challenge of cancer as a complex, multifactorial disease using sophisticated model-based approaches, ranging from relatively coarse genome-wide regulatory and signaling networks to detailed kinetic models of key pathways. These networks and pathways are responsible for implementing cancer-relevant mechanisms and for processing aberrant signals from the spectrum of somatic mutations and heritable variants that contribute to tumor initiation, progression, and drug sensitivity. The ability to assemble and interrogate such cancer models is the direct result of the availability of large sample-matched collections of molecular profiles from thousands of human malignancies, as made available by large consortia, such as TCGA, ICG, and TARGET, among others. This AACR Special Conference complements and ...
http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=29
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q...Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q...
Hepatitis C virus (HCV) infection is a worldwide healthcare problem; however, traditional treatment methods have failed to cure all patients, and HCV has developed resistance to new drugs. Systems biology-based analyses could play an important role in the holistic analysis of the impact of HCV on hepatocellular metabolism. Here, we integrated HCV assembly reactions with a genome-scale hepatocyte metabolic model to identify metabolic targets for HCV assembly and metabolic alterations that occur between different HCV progression states (cirrhosis, dysplastic nodule, and early and advanced hepatocellular carcinoma (HCC)) and healthy liver tissue. We found that diacylglycerolipids were essential for HCV assembly. In addition, the metabolism of keratan sulfate and chondroitin sulfate was significantly changed in the cirrhosis stage, whereas the metabolism of acyl-carnitine was significantly changed in the dysplastic nodule and early HCC stages. Our results explained the role of the upregulated ...
http://kth.diva-portal.org/smash/record.jsf?pid=diva2:931712
The Metabolic Impact of a NADH-producing Glucose-6-phosphate Dehydrogenase in Escherichia coli. | Systems Biology Research Group
In Escherichia coli (E. coli), the oxidative branch of the pentose phosphate pathway (oxPPP) is one of the major sources of NADPH when glucose is the sole carbon nutrient. However, unbalanced NADPH production causes growth impairment as observed in a strain lacking phosphoglucoisomerase (Δpgi). In this work, we studied the metabolic response of this bacterium to the replacement of its glucose-6-phosphate dehydrogenase (G6PDH) by a NADH-producing variant. The homologous enzyme from Leuconostoc mesenteroides was studied by molecular dynamics and site-directed mutagenesis to obtain the NAD-preferring LmG6PDHR46E,Q47E. Through homologous recombination, the zwf loci (encoding for G6PDH) in the chromosomes of wild type (wt) and Δpgi E. coli strains were replaced by DNA encoding for LmG6PDHR46E,Q47E. Contrary to the predictions of a Robustness Analysis performed by flux balances simulation, the replacements caused a substantial effect on the growth rates, increasing 59% in the Δpgi strain, while ...
http://systemsbiology.ucsd.edu/node/979
University of Glasgow - Research Institutes - Institute of Molecular, Cell and Systems Biology - Research - Structural Biology...University of Glasgow - Research Institutes - Institute of Molecular, Cell and Systems Biology - Research - Structural Biology...
Biomolecular nuclear magnetic resonance spectroscopy (NMR) is a very versatile technique that can be used to determine the three dimensional structures of proteins, DNA, RNA, oligosaccharides and small molecules. It can also be used to study conformational changes, intermolecular interactions (both strong and weak), and molecular motion on many timescales in solution. NMR is widely used in metabolomics studies. (and enquiries for this type of application should be directed to Glasgow Polyomics) Solution state NMR complements the other techniques, such as circular dichroism and X-ray crystallography, available in the facility.. Generally, biomacromolecular NMR samples should be prepared with highly purified material, often isotopically labelled with 15N, 13C and even 2H, but NMR has been used e.g. to study proteins in living cells, and ligand-receptor interactions where the receptor comprises an un-purified membrane preparation.. Some guidance on typical sample requirements are given below, but ...
https://www.gla.ac.uk/researchinstitutes/biology/research/structuralbiologybiophysicalcharacterisationfacility/nmrspectroscopy/
Walter Kolch | Systems Biology IrelandWalter Kolch | Systems Biology Ireland
Walter Kolch is Director of Systems Biology Ireland at University College Dublin. A leading international proponent of precision medicine, Kolch originally trained as a clinician, subsequently working in the pharmaceutical industry, research institutes, and academia. He is internationally recognised for his cutting-edge research using systems approaches to understand signalling networks, and is ranked 3rd in the world in precision medicine, 8th in personalised medicine, and amongst the worlds top 50 in proteomics, systems biology, and signal transduction (Google Scholar). Through his leading involvement in pan-European strategic initiatives including Coordinating Action Systems Medicine, Infrastructure for Systems Biology Europe, and the ELIXIR research infrastructure for life science information, Kolch has played a central role in the development of precision medicine policy and funding at both national and international level.. Kolch has designed, developed and coordinated innovative systems ...
http://www.ucd.ie/sbi/team/principalinvestigators/walterkolch/
Hematopoiesis and its disorders: A systems biology approach<...Hematopoiesis and its disorders: A systems biology approach<...
TY - JOUR. T1 - Hematopoiesis and its disorders. T2 - A systems biology approach. AU - Whichard, Zakary L.. AU - Sarkar, Casim A.. AU - Kimmel, Marek. AU - Corey, Seth J.. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2010/3/25. Y1 - 2010/3/25. N2 - Scientists have traditionally studied complex biologic systems by reducing them to simple building blocks. Genome sequencing, high-throughput screening, and proteomics have, however, generated large datasets, revealing a high level of complexity in components and interactions. Systems biology embraces this complexity with a combination of mathematical, engineering, and computational tools for constructing and validating models of biologic phenomena. The validity of mathematical modeling in hematopoiesis was established early by the pioneering work of Till and McCulloch. In reviewing more recent papers, we highlight deterministic, stochastic, statistical, and network-based models that have been used to better understand a ...
https://experts.umn.edu/en/publications/hematopoiesis-and-its-disorders-a-systems-biology-approach
Systems Biology Approach to Identify Biomarkers and Risk Factors of Heat Injury / Stroke Susceptibility | www.icb.ucsb.eduSystems Biology Approach to Identify Biomarkers and Risk Factors of Heat Injury / Stroke Susceptibility | www.icb.ucsb.edu
Heat stroke (HS) is a life-threatening illness induced by prolonged exposure to a hot environment that causes central nervous system abnormalities and severe hyperthermia. There is a critical military medical need to identify biomarkers, risk factors & intervention strategies to decrease heat injury/stroke (HI/S) susceptibility. Current data suggest that the pathophysiological responses to heatstroke may not be due to the immediate effects of heat exposure per se but the result of a systemic inflammatory response syndrome (SIRS) that ensues following thermal injury. Recent evidence suggests that prior infection (viral & bacterial) or prior heat injury increases Warfighter susceptibility to HI/S by deactivating molecular inflammatory mechanisms that protect against multi-organ damage & failure. Exploiting a Systems Biology approach - which focuses on the complex interactions in biological systems - can help to understand the role of cytokines in the thermoregulatory and inflammatory responses to ...
https://www.icb.ucsb.edu/research/completed-projects/systems-biology-approach-identify-biomarkers-and-risk-factors-heat
Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach | BMC Medicine | Full TextRelationship between salivary/pancreatic amylase and body mass index: a systems biology approach | BMC Medicine | Full Text
Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of AMY1A (encoding AMY1) or AMY2A (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between AMY1A copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index (BMI)-related plasma metabolites
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0784-x/tables/3
Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach - UQ eSpace
Background: Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. Methods: We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D.E.S.I.R. longitudinal study. The effect of the number of copies of AMY1A (encoding AMY1) or AMY2A (encoding AMY2) measured through droplet digital PCR was then analyzed on the same parameters in the same study. A Mendelian randomization analysis was also performed. We subsequently assessed the association between AMY1A copy number and obesity risk in two case-control studies (5000 samples in total). Finally, we assessed the association between body mass index ...
https://espace.library.uq.edu.au/view/UQ:504843
University of Glasgow - Research Institutes - Institute of Molecular, Cell and Systems Biology - Research - Plant ScienceUniversity of Glasgow - Research Institutes - Institute of Molecular, Cell and Systems Biology - Research - Plant Science
The Plant Science Group (PSG) maintains a broad interest in understanding how plant growth and development is regulated by environmental stimuli and how plants cope with a changing environment. Our research focuses on identifying the molecular mechanisms underlying physiological and developmental adaptation to environmental cues, such as light quality and day length, as well as environmental stress factors such as drought, high temperatures and salinity.. Our aim is to gain fundamental insights into the cellular and molecular mechanisms of plant growth and development, which determine survival in natural ecosystems and yield and quality traits in agriculture. Plant performance is intricately tied to photosynthetic efficiency, water usage and mineral uptake. Increasing crop productivity will depend on modulating such processes if we are to offer new strategies to meet the growing demand for energy and food security.. Our research also employs synthetic biology and systems approaches to tackle ...
https://www.gla.ac.uk/researchinstitutes/biology/research/plantscience/
आयुष दर्पण: Systems biology research study reveals benefits of vacation and meditationआयुष दर्पण: Systems biology research study reveals benefits of vacation and meditation
Scientists from the Icahn School of Medicine at Mount Sinai, the University of California, San Francisco, and Harvard Medical School used a rigorous study design to assess the biological impact of meditation compared to vacation. They examined the effect of meditation on gene expression patterns in both novice and regular meditators. The researchers found that a resort vacation provides a strong and immediate impact on molecular networks associated with stress and immune pathways, in addition to short- term improvements in well-being, as measured by feelings of vitality and distress. A meditation retreat, for those who already used meditation regularly, was associated with molecular networks characterized by antiviral activity. The molecular signature of long-term meditators was distinct from the non-meditating vacationers. The study was published today in Springer Natures journalTranslational Psychiatry ...
http://ayushdarpan.blogspot.com/2016/09/systems-biology-research-study-reveals.html
Molecular Responses to Climate and Resource Availability: Emerging Evidence from Systems Biology Research in Populus. (Journal...Molecular Responses to Climate and Resource Availability: Emerging Evidence from Systems Biology Research in Populus. (Journal...
The emergence of Populus as a model system for tree biology continues to be driven by a community of scientists dedicated to developing the resources needed to undertake genetic and functional genomic studies in this genus. As a result, understanding the molecular processes that underpin the growth and development of cottonwood, aspen, and hybrid poplar has steadily increased over the last several decades. Recently, our ability to examine the basic mechanisms whereby trees respond to a changing climate and resource limitations has benefitted greatly from the sequencing of the P. trichocarpa genome. This landmark event has laid a solid foundation upon which tree biologists can now explore the genome-wide effects of temperature, water and nutrient limitations on processes that govern the growth and development of some of the longest living and tallest growing organisms on Earth. Although the challenges likely to be encountered by scientists who work with trees are many, recent literature provides ...
https://www.osti.gov/scitech/biblio/966738
Advisory Council Minutes, January 28-29, 2016 - National Institute of General Medical SciencesAdvisory Council Minutes, January 28-29, 2016 - National Institute of General Medical Sciences
Contact: Dr. Douglas Sheeley, 301-451-6446, [email protected] VII. Presentation: Analysis of the National Centers for Systems Biology Program , [PDF, 668KB]. The National Centers for Systems Biology (NCSB) program was established by NIGMS in 2002 to facilitate pioneering research in systems biology and to stimulate the field as a whole. In 2014, NIGMS initiated an analysis of the NCSB program to better understand whether the program has met its goals, to assess the programs effectiveness in promoting systems biology research and to view the current state of maturity for systems biology as a field. Dr. Andrew Miklos of the NIGMS Office of Program Planning, Analysis, and Evaluation presented a brief overview of the types of data made available for consideration to the assessment panel of subject matter experts serving as a working group of Council.. Contact: Dr. Andrew Miklos, 301-451-4645, [email protected] VIII. Presentation: Assessment and Recommendations for the National Centers for ...
https://www.nigms.nih.gov/about/council/minutes/Pages/jan28-29_2016.aspx
A comprehensive collection of systems biology data characterizing the host response to viral infection (Journal Article) | DOE...A comprehensive collection of systems biology data characterizing the host response to viral infection (Journal Article) | DOE...
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). As ...
https://www.osti.gov/pages/biblio/1167599-comprehensive-collection-systems-biology-data-characterizing-host-response-viral-infection
Systems Biology | School of Biotechnology and Biomolecular SciencesSystems Biology | School of Biotechnology and Biomolecular Sciences
Systems biology research is the study of genes and proteins as an interconnected networks series of interconnected networks and pathways. UNSW adopts a holistic approach to build a molecular profile of an organism.
https://www.babs.unsw.edu.au/research/genomics-and-bioinformatics/systems-biology
Publications | Max Planck Institute of Molecular Plant Physiology
Basler, G.; Grimbs, S.; Selbig, J.; Nikoloski, Z.: Thermodynamic landscapes of randomized large-scale metabolic networks. In: 7th International Workshop on Computational Systems Biology, WCSB 2010, pp. 23 - 26 (Eds. Nykter, M.; Ruusuvuori, P.; Carlberg, C.; Yli-Harja, O.). 7th International Workshop on Computational Systems Biology, WCSB 2010, Luxembourg, LUX. Tampere International Center for Signal Processing (2010 ...
https://www.mpimp-golm.mpg.de/publication-search/2022879?deactivate_global_blacklist=false&page=1&person=%2Fpersons%2Fresource%2Fpersons97064
Publikationen von Roosa Laitinen | Max-Planck-Institut für Molekulare Pflanzenphysiologie
Basler, G.; Grimbs, S.; Selbig, J.; Nikoloski, Z.: Thermodynamic landscapes of randomized large-scale metabolic networks. In: 7th International Workshop on Computational Systems Biology, WCSB 2010, S. 23 - 26 (Hg. Nykter, M.; Ruusuvuori, P.; Carlberg, C.; Yli-Harja, O.). 7th International Workshop on Computational Systems Biology, WCSB 2010, Luxembourg, LUX. Tampere International Center for Signal Processing (2010 ...
https://www.mpimp-golm.mpg.de/publication-search/1749381?person=%2Fpersons%2Fresource%2Fpersons97175
After the Human Genome Project: Systems Biology and Predictive, Preventive and Personalized Medicine | Institute for...After the Human Genome Project: Systems Biology and Predictive, Preventive and Personalized Medicine | Institute for...
The Human Genome Project has catalyzed the emergence of a new approach to biology termed systems biology. Systems biology analyzes all the interrelationships of the elements in a biological system, rather than studying them one at a time, as has been the modus operandi in biology for the past 30 years. This systems approach has also emerged in the context of the view biology
http://www.ima.umn.edu/2003-2004/PUB9.15.03/19787
British Library EThOS: Using ontology and semantic web services to support modeling in systems biologyBritish Library EThOS: Using ontology and semantic web services to support modeling in systems biology
This thesis addresses the problem of collaboration among experimental biologists and modelers in the study of systems biology by using ontology and Semantic Web Services techniques. Modeling in systems biology is concerned with using experimental information and mathematical methods to build quantitative models across different biological scales. This requires interoperation among various knowledge sources and services. Ontology and Semantic Web Services potentially provide an infrastructure to meet this requirement. In our study, we propose an ontology-centered framework within the Semantic Web infrastructure that aims at standardizing various areas of knowledge involved in the biological modeling processes. In this framework, first we specify an ontology-based meta-model for building biological models. This meta-model supports using shared biological ontologies to annotate biological entities in the models, allows semantic queries and automatic discoveries, enables easy model reuse and ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564689
Our TeamOur Team
Dr. Kretzler is the Warner-Lambert/Parke-Davis Professor of Internal Medicine/Nephrology and Computational Medicine and Bioinformatics. The overarching goal of his research is to define chronic organ dysfunction in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he has developed a translational research pipeline centered on integrated systems biology analysis of renal disease.. He leads the U54 Nephrotic Syndrome Research Network (Neptune) in the Rare Disease Clinical Research Network II, is a Principle Investigator (PI) of the Coordinating center of the CureGN research network, the Director of the Applied Systems Biology Core, PI in the R24 Integrated Systems Biology Approach to Diabetic Microvascular Complications and site PI in the NIH Acceleration of Medicine (AMP) program in lupus.. He has 20 years of experience in integration of bioinformatics, molecular and clinical approaches in more than 210 publications. He has a track record on ...
https://www.miktmc.org/about/our-team/
Protein Movement Across Membranes PDF - Free books downloadProtein Movement Across Membranes PDF - Free books download
This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly ...
https://medicalbooksfreedownload.com/protein-movement-across-membranes-pdf/
Online Systems Biology And Biotechnology Of Escherichia Coli 2009
Rousseau not Was to online systems biology and, pulsing to be a menyenangkan with the intermediate bassinet. very he seemed a much online proof, a collective cut but one which he were on Marion, another region. also, their surprised online systems biology and biotechnology applied them both.
http://ambrosia-kosmetik.de/images/engine/book.php?q=online-systems-biology-and-biotechnology-of-escherichia-coli-2009/
Systems biology analysis of iron metabolismSystems biology analysis of iron metabolism
Jede Zelle des Säugetierorganismus benötigt Eisen als Spurenelement für zahlreiche oxidativ-reduktive Elektronentransfer-Reaktionen und für Transport und Speicherung von Sauerstoff. Der Organismus unterhält daher ein komplexes Regulationsnetzwerk für die Aufnahme, Verteilung und Ausscheidung von Eisen. Die intrazelluläre Regulation in den verschiedenen Zelltypen des Körpers ist mit einer globalen hormonellen Signalstruktur verzahnt. Sowohl Eisenmangel wie Eisenüberschuss sind häufige und ernste menschliche Krankheitsbilder. Sie betreffen jede Zelle, aber auch den Organismus als Ganzes. In dieser Dissertation wird ein mathematisches Modell des Eisenstoffwechsels der erwachsenen Maus vorgestellt. In ihm wird die Flussbilanz des Eisens in den wichtigsten Zelltypen in Form von transmembranalen und intrazellulären kinetischen Gleichungen dargestellt, und es werden diese Zellmodelle mit dem zentralen Eisenaustausch-Kompartiment (Blutplasma) des Körpers integriert. Der Eisenstatus wird ...
https://edoc.hu-berlin.de/handle/18452/17069
Medical Systems Biology | Max Delbrück Center for Molecular MedicineMedical Systems Biology | Max Delbrück Center for Molecular Medicine
In combination with the major disease oriented programs of the MDC, Medical Systems Biology is an essential strategic and overarching component of the scientific profile of the MDC: the Berlin Institute for Medical Systems Biology (BIMSB) was launched in 2008. The scientific concept was initiated by Nikolaus Rajewsky, who is now leading the program and its further developments.
https://www.mdc-berlin.de/bimsb
Integrative Analyses of Hepatic Differentially Expressed Genes and Blood Biomarkers during the Peripartal Period between Dairy...
Using published dairy cattle liver transcriptomics dataset along with novel blood biomarkers of liver function, metabolism, and inflammation we have attempted an integrative systems biology approach applying the classical functional enrichment analysis using DAVID, a newly-developed Dynamic Impact Approach (DIA), and an upstream gene network analysis using Ingenuity Pathway Analysis (IPA). Transcriptome data was generated from experiments evaluating the impact of prepartal plane of energy intake [overfed (OF) or restricted (RE)] on liver of dairy cows during the peripartal period. Blood biomarkers uncovered that RE vs. OF led to greater prepartal liver distress accompanied by a low-grade inflammation and larger proteolysis (i.e., higher haptoglobin, bilirubin, and creatinine). Post-partum the greater bilirubinaemia and lipid accumulation in OF vs. RE indicated a large degree of liver distress. The re-analysis of microarray data revealed that expression of ,4,000 genes was affected by diet x ...
https://ir.library.oregonstate.edu/concern/articles/sn00b062t
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data...Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data...
프로토콜은 인간 배아 줄기 세포 및 사체 연구에 기초하여 두 개의 시험관 발생 독성 시험 시스템 (UKK 및 UKN1)를 설명한다. 테스트 시스템은 인간 발생 독성 위험을 예측하고, 동물 연구, 비용 및 화학 물질의 안전성...
https://www.jove.com/v/52333?language=Korean
Bioinformatics and Computational Biology Theses and Dissertations | Bioinformatics and Computational Biology | Iowa State...Bioinformatics and Computational Biology Theses and Dissertations | Bioinformatics and Computational Biology | Iowa State...
The Bioinformatics and Computational Biology graduate program emphasizes interdisciplinary training in nine related areas of focus: Bioinformatics, Computational Molecular Biology, Structural and Functional Genomics, Macromolecular Structure and Function, Metabolic and Developmental Networks, Integrative Systems Biology, Information Integration and Data Mining, Biological Statistics, and Mathematical Biology ...
http://lib.dr.iastate.edu/bcb_etd/
Unraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biologyUnraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biology
Sexually transmitted infections (STIs) unequivocally represent a major public health concern in both industrialized and developing countries. Previous efforts to develop vaccines for systemic immunization against a large number of STIs in humans have been unsuccessful. There is currently a drive to develop mucosal vaccines and adjuvants for delivery through the genital tract to confer protective immunity against STIs. Identification of molecular signatures that can be used as biomarkers for adjuvant potency can inform rational development of potent mucosal adjuvants. Here, we used systems biology to study global gene expression and signature molecules and pathways in the mouse vagina after treatment with two classes of experimental adjuvants. The Toll-like receptor 9 agonist CpG ODN and the invariant natural killer T cell agonist alpha-galactosylceramide, which we previously identified as equally potent vaginal adjuvants, were selected for this study. Our integrated analysis of genome-wide transcriptome
http://publications.lib.chalmers.se/publication/158661-unraveling-molecular-signatures-of-immunostimulatory-adjuvants-in-the-female-genital-tract-through-s
Frontiers | A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts...Frontiers | A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts...
Nonalcoholic fatty liver disease (NAFLD) comprises a broad spectrum of disease states ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). As a result of increases in the prevalences of obesity, insulin resistance, and hyperlipidemia, the number of people with hepatic steatosis continues to increase. Differences in susceptibility to steatohepatitis and its progression to cirrhosis have been attributed to a complex interplay of genetic and external factors all addressing the intracellular network. Increase in sugar or refined carbohydrate consumption results in an increase of insulin and insulin resistance that can lead to the accumulation of fat in the liver. Here we demonstrate how a multidisciplinary approach encompassing cellular reprogramming, transcriptomics, proteomics, metabolomics, modeling, network reconstruction and data management can be employed to unveil the mechanisms underlying the progression of steatosis. Proteomics revealed reduced AKT/mTOR signaling in fibroblasts
https://www.frontiersin.org/articles/10.3389/fphys.2012.00339/full
Institute for Systems Biology Appoints Pioneer in Systems Genetics to Leadership Role | FierceBiotechInstitute for Systems Biology Appoints Pioneer in Systems Genetics to Leadership Role | FierceBiotech
Institute for Systems Biology Appoints Pioneer in Systems Genetics to Leadership Role Joseph Nadeau Named as Director of Research and Academic Affairs SEATTLE--(BUSINESS WIRE)--The Institute for
https://www.fiercebiotech.com/biotech/institute-for-systems-biology-appoints-pioneer-systems-genetics-to-leadership-role
IET Digital Library: Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser...IET Digital Library: Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser...
The combination of microfluidic cell trapping devices with ion mobility-mass spectrometry offers the potential for elucidating in real time the dynamic responses of small populations of cells to paracrine signals, changes in metabolite levels and delivery of drugs and toxins. Preliminary experiments examining peptides in methanol and recording the interactions of yeast and Jurkat cells with their superfusate have identified instrumental set-up and control parameters and online desalting procedures. Numerous initial experiments demonstrate and validate this new instrumental platform. Future outlooks and potential applications are addressed, specifically how this instrumentation may be used for fully automated systems biology studies of the significantly interdependent, dynamic internal workings of cellular metabolic and signalling pathways.
http://digital-library.theiet.org/content/journals/10.1049/iet-syb.2010.0012
A systems biology approach to understanding atherosclerosis | EMBO Molecular MedicineA systems biology approach to understanding atherosclerosis | EMBO Molecular Medicine
The application of both pathway (Cagnin et al, 2009) and ad hoc (Skogsberg et al, 2008) network analysis has facilitated extraction of biologically meaningful information from microarray messenger RNA (mRNA) studies of atherosclerotic plaques. Such studies are critical in that they analyse disease‐relevant tissue [e.g. whole mouse aorta (Skogsberg et al, 2008) or human coronary and carotid arteries (Cagnin et al, 2009)] but they pose numerous analysis challenges. For example, the lesion samples contain a mix of cell types obtained at a fixed time point. These studies allow the construction of a parts list of molecules that may participate in the process-which is extremely useful in the interpretation and analysis of complementary in vitro studies. However, to go beyond such lists requires the application of network analysis. By doing this type of analysis the authors provided insights into disease pathogenesis that would not otherwise have been apparent. For example, network analysis of ...
http://embomolmed.embopress.org/content/2/3/79
IJMS | Free Full-Text | Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium...IJMS | Free Full-Text | Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium...
Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid
http://www.mdpi.com/1422-0067/16/2/2913
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology AnalysisMechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis
Autophagy plays an essential role in cell survival/death and functioning. Modulation of autophagy has been recognized as a promising therapeutic strategy against diseases/disorders associated with uncontrolled growth or accumulation of biomolecular aggregates, organelles or cells including those caused by cancer, aging, neurodegeneration, and liver diseases such as α1-antitrypsin deficiency. Numerous pharmacological agents that enhance or suppress autophagy have been discovered. However, their molecular mechanisms of action are far from clear. Here we collected a set of 225 autophagy modulators and carried out a comprehensive quantitative systems pharmacology (QSP) analysis of their targets using both existing databases and predictions made by our machine learning algorithm. Autophagy modulators include several highly promiscuous drugs (e.g. artenimol and olanzapine acting as activator, fostamatinib as inhibitor, or melatonin as dual-modulator), as well as selected drugs uniquely targeting specific
https://www.researchhub.com/paper/771147/mechanisms-of-action-of-autophagy-modulators-dissected-by-quantitative-systems-pharmacology-analysis
Abstract 88: Systems Biology Approaches to Exploring Molecular Mechanisms Underlying Blood Pressure Regulation | HypertensionAbstract 88: Systems Biology Approaches to Exploring Molecular Mechanisms Underlying Blood Pressure Regulation | Hypertension
Blood pressure (BP) is a complex trait that is influenced by both genetic and environment factors. Recent genome-wide association studies (GWAS) have identified about 30 genetic loci that are associated with systolic and diastolic blood pressure (SBP, DBP) and hypertension. However, the molecular mechanisms underlying the GWAS associations remain unclear. We hypothesize that BP-associated genetic variants with both strong and subtle effects drive shifts in gene subnetworks that in turn affect BP. We surveyed BP-associated molecular interactions in Framingham offspring cohort participants (n=2461; 55% women; age range 40-92 yrs.) by integrating gene expression profiles, expression-associated SNPs (eSNPs), and BP GWAS with network approaches. Peripheral whole blood samples were collected and large-scale transcriptomic microarray analysis was performed on all available participants who attended a clinic visit in 2005-2008. Based on pedigrees the samples were split into a discovery set (n=1421) and ...
http://hyper.ahajournals.org/content/60/Suppl_1/A88
Frontiers | Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach | Frontiers in Aging...Frontiers | Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach | Frontiers in Aging...
Alzheimers disease (AD) is the most common cause of dementia worldwide. One of the main pathological changes that occurs in AD is the intracellular accumulation of hyperphosphorylated Tau protein in neurons. Cyclin-dependent kinase 5 (CDK5) is one of the major kinases involved in Tau phosphorylation, directly phosphorylating various residues and simultaneously regulating various substrates such as kinases and phosphatases that influence Tau phosphorylation in a synergistic and antagonistic way. It remains unknown how the interaction between CDK5 and its substrates promotes Tau phosphorylation, and systemic approaches are needed that allow an analysis of all the proteins involved. In this review, the role of the CDK5 signaling pathway in Tau hyperphosphorylation is described, an in silico model of the CDK5 signaling pathway is presented. The relationship among these theoretical and computational models shows that the regulation of Tau phosphorylation by PP2A and glycogen synthase kinase 3β (GSK3β) is
https://www.frontiersin.org/articles/10.3389/fnagi.2014.00232/full
ChEBI and genome scale metabolic reconstructionsChEBI and genome scale metabolic reconstructions
ChEBI and genome-scale metabolic reconstructions Neil Swainston Manchester Centre for Integrative Systems Biology 2 nd ChEBI User Group Workshop, EMBL-EBI, Hi…
https://www.slideshare.net/neilswainston/chebi-and-genome-scale-metabolic-reconstructions
VackvSuG: YWHAB systems biology approach mechanistically promoting the holoenzyme protein chains A and B in a codominant...VackvSuG: YWHAB systems biology approach mechanistically promoting the holoenzyme protein chains A and B in a codominant...
This ${affineX}. Is licensed under a Creative Commons ${SC-} License. In addition to the (SLA) licenses including the enhanced (UBMTA) and the release that forms the ease that dosent while mininizing the cost s of publication of this document were not defrayed in part or in whole by the payment of page charges. The document must therefore be hereby marked non-advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact unless otherwise indicated by authors with competing interest statments found herein. Content for informational and educational use only. All rights reserved. The contents provided here are solely the responsibility of the author and dose not identify or necessarily represent the official views, components of/or by a Science Education Partnership, Awards, or the NIH Research Resources/ Human Health Services. The Administration has offered regulations from the Department of Health and Human Services (Standards for Privacy of Individually Identifiable ...
http://lnwme.blogspot.com/2009/08/ywhab-systems-biology-approach.html
Synthetic Biology 2018 | Conferenceseries| Europe | Rome | ItalySynthetic Biology 2018 | Conferenceseries| Europe | Rome | Italy
Applications on Synthetic Biology, Synthetic Biology conservation, Genomics Products, Synthetic Biology products, Metabolomics, Computational Systems Biology Conference, Structural Biology, Chemical Biology, Stem Cell Biology
https://syntheticbiology.conferenceseries.com/2017/conference-brochure.php
Thermodynamics of Biomolecular Systems | Biological Engineering | MIT OpenCourseWareThermodynamics of Biomolecular Systems | Biological Engineering | MIT OpenCourseWare
This subject deals primarily with equilibrium properties of macroscopic and microscopic systems, basic thermodynamics, chemical equilibrium of reactions in gas and solution phase, and macromolecular interactions.
https://ocw.mit.edu/courses/biological-engineering/20-110j-thermodynamics-of-biomolecular-systems-fall-2005/
Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy Switch to...Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy Switch to...
This trial is investigating the pharmacodynamics of raltegravir with emtricitabine/tenofovir disoproxil fumarate in patients with chronic HIV 1 infections
https://adisinsight.springer.com/trials/700238702?error=cookies_not_supported&code=82b0b500-7453-439f-b7dd-9d34ed34ef70
An Introduction to Systems Biology: Design Principles of Biological Circuits - Uri Alon - Google BooksAn Introduction to Systems Biology: Design Principles of Biological Circuits - Uri Alon - Google Books
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
https://books.google.com/books/about/An_Introduction_to_Systems_Biology.html?hl=de&id=tcxCkIxzCO4C
Discovery of how colorectal cancer drug works will help more patients - BIOENGINEER.ORGDiscovery of how colorectal cancer drug works will help more patients - BIOENGINEER.ORG
In a cell with no KRAS mutations, a known tumor suppressor called neurofibromin keeps healthy KRAS proteins well-behaved. But most KRAS mutations are overly active and cannot be controlled by neurofibromin. When mutated KRAS is present, neurofibromin attempts to control the mutant KRAS at the expense of controlling the healthy KRAS. So why is the KRAS G13D mutation any different? Why does it respond to Cetuximab? The scientists discovered that even though KRAS G13D is overly active, it is doing so without neurofibromin being aware. Thus, neurofibromin can still keep the healthy KRAS under control. Additionally, the researchers demonstrated that cetuximab will only work to suppress tumors as long as there is neurofibromin available to suppress the activity of healthy KRAS. This work demonstrates the power of computational systems biology approaches to address problems in personalized medicine, says Stites. Doctors could sequence the gene to find out if the patient has this KRAS G13D variant, ...
https://bioengineer.org/discovery-of-how-colorectal-cancer-drug-works-will-help-more-patients/
Cell and Systems Biology | Faculty of Arts & Science CalendarCell and Systems Biology | Faculty of Arts & Science Calendar
The study of life, biology, has been transformed in recent decades by powerful new ways of asking fundamental questions about how living organisms work. In particular, molecular approaches are revealing both the incredible complexity of organization at the cellular level, and the underlying principles drawn from chemistry, physics and information science that will eventually enable us to understand that complexity.. The Department of Cell and Systems Biology brings together biologists who study life at the level of molecules to functioning individual organisms. Our undergraduate programs reflect this diversity and research strength. Since cells are the basic units of life, it is important to understand how molecular mechanisms control cells and how cells organize the developmental and physiological processes of whole organisms. These relationships encompass molecular biology, cell biology, developmental biology, genetics and physiology. These relationships are also complex, requiring studies of ...
https://fas.calendar.utoronto.ca/section/Cell-and-Systems-Biology
Ocasys: Ocasys: Online OnderwijscatalogusOcasys: Ocasys: Online Onderwijscatalogus
The aim of this course is that the students learn how to combine graph theory and probability theory to infer graphical models from real-world data. In the course we will focus on Bayesian networks, which can for example be used to infer gene regulatory networks and protein pathways in systems biology research. After a very brief introduction to typical biological applications, we will consider Bayesian networks from a statistical perspective. As Bayesian networks bring together graph theory and probability theory, we will first discuss various graph theoretical concepts, before we can start modelling graphs statistically ...
https://www.rug.nl/ocasys/rug/vak/showpos?opleiding=4906
Bioinformatic identification of disease driver networks using functional profiling data
Genomics-based drug discovery utilizing sequencing data for elucidation of candidate targets has led to the development of a number of successful treatments in the last decades. However, the molecular driver signals for many complex diseases cannot be easily derived from genome sequencing. Functional profiling studies, such as those involving the detection of protein interaction networks or the effects of perturbations with small molecules or siRNAs on cellular phenotypes, offer a complementary approach for the identification of molecular vulnerabilities that can be exploited in the development of new treatment strategies. The goal of this thesis was to develop computational systems biology methods for supporting such functional endeavors, and through their application use cases, to elucidate novel disease driver signals in cancer and Alzheimers disease networks. The availability of functional profiling data (such as biochemical target selectivity information or efficacy readouts) for numerous ...
https://helda.helsinki.fi/handle/10138/230923
Merelli Ivan - DISCo - Università degli Studi di Milano-Bicocca
Titolo ricerca:Image based surface matching oriented to macromolecular functionalannotation and interaction screening Short CV: Ivan Merelli received the Master of Science in Biomedical Engineering from the Politecnico di Milano, with a thesis about molecular surface modelling and analysis. In February 2009 he received a PhD in Computer Science from the Università di Milano Bicocca with a research about surface matching for macromolecular docking. His research activities concern the development of software for sequence based genomics and for structural proteomics researches, with particular interest in protein-protein interactions. He works actively on the implementation of high performance bioinformatics software using cluster infrastructures and grid distributed platforms. He has been involved in the development of databases and computational solutions for projects of Integrative System Biology, gene expression analyses and drug discovery. Nowadays he is researcher at Institute of Biomedical ...
http://www.disco.unimib.it/go/Home/Italiano/Formazione-e-Post-Laurea/Per-chi-si-vuole-iscrivere/Offerta-Formativa/Dottorato-di-Ricerca-in-Informatica/Pagine-personali-dottorandi/G-O/Merelli-Ivan
Systems biologySystems biology
... a systematic study of physiome in biology. Cancer systems biology is an example of the systems biology approach, which can be ... Systems biology was begun as a new field of science around 2000, when the Institute for Systems Biology was established in ... Systems biology is the computational and mathematical analysis and modeling of complex biological systems. It is a biology- ... ISBN 978-1-4419-9864-4. Look up systems biology in Wiktionary, the free dictionary. Biological Systems in bio-physics-wiki (CS1 ...
https://en.wikipedia.org/wiki/Systems_biology
Cancer systems biologyCancer systems biology
Systems biology Bioconductor Wang, Edwin. Cancer Systems Biology. Chapman & Hall, 2010 Liu & Lauffenburger. Systems Biomedicine ... Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the ... Cancer systems biology represents the application of systems biology approaches to the analysis of how the intracellular ... Cancer systems biology encompasses concrete applications of systems biology approaches to cancer research, notably (a) the need ...
https://en.wikipedia.org/wiki/Cancer_systems_biology
Molecular Systems BiologyMolecular Systems Biology
... is a peer-reviewed open-access scientific journal covering systems biology at the molecular level ( ... Molecular and cellular biology journals, Systems biology, Publications established in 2005, English-language journals, Monthly ... "Molecular Systems Biology :". www.embopress.org. Retrieved 2020-10-20. "EMBO announces the launch of EMBO Press". Retrieved Jan ... Media related to Molecular Systems Biology at Wikimedia Commons Official website Portal: Science v t e (Articles with short ...
https://en.wikipedia.org/wiki/Molecular_Systems_Biology
Complex systems biologyComplex systems biology
... of simpler systems in CSB. A meta-system is a system of systems. Autopoiesis also models such a biological system of systems, ... Relational biology Systems science portal Mathematics portal Complexity Complex system Biological system Dynamical system ... systems theory Emergence Mathematical and theoretical biology Pattern oriented modeling Systems biology Systems theory Systems ... claim that in biology a meta-system is not equivalent to such a system of systems. They also claim it differs from the meta- ...
https://en.wikipedia.org/wiki/Complex_systems_biology
BMC Systems BiologyBMC Systems Biology
... was an open access peer-reviewed scientific journal that covered research in systems biology. Filling a gap ... "BMC Systems Biology". BMC Systems Biology. Archived from the original on 7 May 2017. Retrieved 23 July 2017. Mendes, Pedro (18 ... BMC Systems Biology, a new open access journal". BMC Systems Biology. 1: 41. doi:10.1186/1752-0509-1-41. ISSN 1752-0509. PMC ... Systems and Synthetic Biology (until 2015) Wikimedia Commons has media related to Media from BMC Systems Biology. Hodgkinson, ...
https://en.wikipedia.org/wiki/BMC_Systems_Biology
Systems Biology OntologySystems Biology Ontology
The Systems Biology Ontology (SBO) is a set of controlled, relational vocabularies of terms commonly used in systems biology, ... The rise of Systems Biology, seeking to comprehend biological processes as a whole, highlighted the need to not only develop ... The Systems Biology Pathway Exchange (SBPAX) allows SBO terms to be added to Biological Pathway Exchange (BioPAX). This links ... March 2003). "The systems biology markup language (SBML): A medium for representation and exchange of Biochemical Network ...
https://en.wikipedia.org/wiki/Systems_Biology_Ontology
Systems Biology IrelandSystems Biology Ireland
Systems biology, Systems science institutes, Medical research institutes in the Republic of Ireland, University College Dublin ... and works in the areas of systems biology, systems medicine and personalised medicine. SBI designs new therapeutic approaches ... Systems Biology Ireland (SBI) is a Science Foundation Ireland (SFI) funded Centre for Science, Engineering and Technology ... 15m in new systems biology research centre". Archived from the original on 19 July 2011. Steven E. F. Brown (7 October 2009). " ...
https://en.wikipedia.org/wiki/Systems_Biology_Ireland
Systems Biology Graphical NotationSystems Biology Graphical Notation
"Systems Biology Graphical Notation". Systems Biology Graphical Notation. Retrieved 2020-08-11. Moodie SL, Le Novère N, Demir E ... The Systems Biology Graphical Notation (SBGN) is a standard graphical representation intended to foster the efficient storage, ... 2009). "The Systems Biology Graphical Notation". Nat Biotechnol. 27 (8): 735-41. doi:10.1038/nbt.1558. PMID 19668183. " ... The meeting that initiated development of the Systems Biology Graphical Notation took place on February 11-12, 2006, at the ...
https://en.wikipedia.org/wiki/Systems_Biology_Graphical_Notation
Institute for Systems BiologyInstitute for Systems Biology
List of systems sciences organizations "Institute for Systems Biology - Home". Institute for Systems Biology. Retrieved 17 ... "Institute for Systems Biology - Research". Institute for Systems Biology. Retrieved 17 March 2012. Dietrich, Bill (9 February ... Hood, L.; Rowen, L.; Galas, D. J.; Aitchison, J. D. (2008). "Systems biology at the Institute for Systems Biology". Briefings ... "Institute for Systems Biology - Publications". Institute for Systems Biology. Retrieved 17 March 2012. "P4 Medicine Institute ...
https://en.wikipedia.org/wiki/Institute_for_Systems_Biology
Systems and Synthetic BiologySystems and Synthetic Biology
... is a peer-reviewed scientific journal covering systems and synthetic biology. It was established ... Molecular and cellular biology journals, Systems biology, Synthetic biology, English-language journals, Hybrid open access ... "Systems and Synthetic Biology , Volumes and issues". SpringerLink. Retrieved 12 June 2021. Official website v t e (Articles ...
https://en.wikipedia.org/wiki/Systems_and_Synthetic_Biology
Systems Biology in Reproductive MedicineSystems Biology in Reproductive Medicine
The editor-in-chief of Systems Biology in Reproductive Medicine is S. A. Krawetz (Wayne State University). "Systems in Biology ... Systems Biology in Reproductive Medicine is a peer-reviewed medical journal that covers the use of systems approaches including ... "Systems Biology in Reproductive Medicine - Editorial Board". informahealthcare.com. Retrieved 2010-01-20. Official website ( ... The journal publishes research involving human and animal gametes, stem cells, developmental biology, toxicology, and clinical ...
https://en.wikipedia.org/wiki/Systems_Biology_in_Reproductive_Medicine
International Conference on Systems BiologyInternational Conference on Systems Biology
The International Conference on Systems Biology (ICSB) is the primary international conference for systems biology research. ... Systems biology, Biology conferences, All stub articles, Biology organization stubs). ... International Society for Systems Biology v t e (Articles lacking reliable references from May 2009, All articles lacking ... Created by Hiroaki Kitano in 2000, its organization is now coordinated by the International Society for Systems Biology (ISSB ...
https://en.wikipedia.org/wiki/International_Conference_on_Systems_Biology
Intelligent Systems for Molecular BiologyIntelligent Systems for Molecular Biology
Wikimedia Commons has media related to Intelligent Systems for Molecular Biology. European Conference on Computational Biology ... Intelligent Systems for Molecular Biology (ISMB) is an annual academic conference on the subjects of bioinformatics and ... Christopher Rawlings (head of Computational and Systems Biology at Rothamsted Research and organiser of ISMB 1995) has said: " ... Searls, D.; Shavlik, J.; Hunter, L. (1994). "The First International Conference on Intelligent Systems for Molecular Biology". ...
https://en.wikipedia.org/wiki/Intelligent_Systems_for_Molecular_Biology
List of systems biology conferencesList of systems biology conferences
Systems biology is a biological study field that focuses on the systematic study of complex interactions in biological systems ... Systems biology, Biology conferences, Lists of conferences). ...
https://en.wikipedia.org/wiki/List_of_systems_biology_conferences
New South Wales Systems Biology InitiativeNew South Wales Systems Biology Initiative
The New South Wales Systems Biology Initiative Skyrails Visualisation System Updated Research Projects at the Systems Biology ... The Systems Biology Initiative is currently working on an adaptation of the Skyrails Visualisation System. This system, called ... Researchers at the System Biology Initiative have been identifying techniques to identify novel methylated lysine and arginine ... The Systems Biology Initiative is utilising the technique of blue native continuous elution electrophoresis (BN-CEE). This ...
https://en.wikipedia.org/wiki/New_South_Wales_Systems_Biology_Initiative
List of systems biology modeling softwareList of systems biology modeling software
Systems biology relies heavily on building mathematical models to help understand and make predictions of biological processes ... The vast majority of modern systems biology modeling software support SBML, which is the de facto standard for exchanging ... BMC Systems Biology. 7 (1): 74. doi:10.1186/1752-0509-7-74. PMC 3751080. PMID 23927696. Stiles, Joel R.; Van Helden, Dirk; ... "An Automated Biomodel Selection System (BMSS) for Gene Circuit Designs". ACS Synthetic Biology. 8 (7): 1484-1497. doi:10.1021/ ...
https://en.wikipedia.org/wiki/List_of_systems_biology_modeling_software
List of systems biology visualization softwareList of systems biology visualization software
Koblitz, Julia; Schomburg, Dietmar; Neumann-Schaal, Meina (2020). "MetaboMAPS: Pathway sharing and multi-omics data visualization in metabolic context". F1000Research. 9: 288. doi:10.12688/f1000research.23427.2. PMC 7383707. PMID 32765840. (Articles needing additional references from November 2020, All articles needing additional references, Lists of bioinformatics software, Systems biology, Data visualization software ...
https://en.wikipedia.org/wiki/List_of_systems_biology_visualization_software
Bio Fuel SystemsBio Fuel Systems
Their system of bioconversion is said to be more productive than any other plant-based system producing oil or ethanol.[ ... International Congress "Bio-mass and biofuels production from algae oil" : Airemar prototype. "Spanish Firm Claims it Can Make ...
https://en.wikipedia.org/wiki/Bio_Fuel_Systems
Wiley Interdisciplinary Reviews: Systems Biology and MedicineWiley Interdisciplinary Reviews: Systems Biology and Medicine
... (abbreviated WIREs Systems Biology and Medicine) is a bimonthly ... Systems biology, Biology journals, General medical journals, Publications established in 2009, Bimonthly journals, Wiley ( ... peer-reviewed interdisciplinary scientific review journal covering systems biology and medicine. It was established in 2009 and ... publisher) academic journals, English-language journals, All stub articles, Biology journal stubs). ...
https://en.wikipedia.org/wiki/Wiley_Interdisciplinary_Reviews:_Systems_Biology_and_Medicine
Bio Process Systems AllianceBio Process Systems Alliance
The Bio Process Systems Alliance (BPSA) is a biopharmaceutical industry trade group of suppliers of single use components and ... single use systems for manufacturing processes. It was created in 2006 through an alliance of 26 suppliers. DeTommaso, Denise ( ...
https://en.wikipedia.org/wiki/Bio_Process_Systems_Alliance
List of Intelligent Systems for Molecular Biology keynote speakersList of Intelligent Systems for Molecular Biology keynote speakers
"Intelligent Systems on Molecular Biology". Archived from the original on 8 May 2012. Retrieved 27 October 2013. "ISMB 99 - ... The following is a list of Intelligent Systems for Molecular Biology (ISMB) keynote speakers. ISMB is an academic conference on ... Neshich, Goran; Bourne, Philip E.; Brunak, Søren (1 January 2006). "ISMB 2006". PLOS Computational Biology. 2 (2): e11. doi: ... "ISMB". International Society for Computational Biology. Retrieved 27 October 2013. "ISMB-96 Home Page". Archived from the ...
https://en.wikipedia.org/wiki/List_of_Intelligent_Systems_for_Molecular_Biology_keynote_speakers
Biology and sexual orientationBiology and sexual orientation
The biology of sexual orientation has been studied in detail in several animal model systems. In the common fruit fly ... Bio Systems. 31 (2-3): 223-33. doi:10.1016/0303-2647(93)90051-D. PMID 8155854. Baker R (1996). Sperm Wars: The Science of Sex ( ... The relationship between biology and sexual orientation is a subject of research. While scientists do not know the exact cause ... Hamer D, Copeland P (1994). The Science of Desire: The Search for the Gay Gene and the Biology of Behavior. Simon and Schuster ...
https://en.wikipedia.org/wiki/Biology_and_sexual_orientation
BiologyBiology
The plant body is made up of organs that can be organized into two major organ systems: a root system and a shoot system. The ... Biology in fiction Glossary of biology List of biological websites List of biologists List of biology journals List of biology ... The enteric nervous system functions to control the gastrointestinal system. Both autonomic and enteric nervous systems ... A circulatory system usually consists of a muscular pump such as a heart, a fluid (blood), and system of blood vessels that ...
https://en.wikipedia.org/wiki/Biology
Kingdom (biology)Kingdom (biology)
The five kingdom system may be combined with the two empire system. In the Whittaker system, Plantae included some algae. In ... When Carl Linnaeus introduced the rank-based system of nomenclature into biology in 1735, the highest rank was given the name " ... Following publication of Whittaker's system, the five-kingdom model began to be commonly used in high school biology textbooks ... The two-empire system would later be expanded to the three-domain system of Archaea, Bacteria, and Eukaryota. The differences ...
https://en.wikipedia.org/wiki/Kingdom_(biology)
Max Planck Institute for Infection BiologyMax Planck Institute for Infection Biology
"Molecular Biology". www.mpiib-berlin.mpg.de. Retrieved 8 June 2020. "Systems Infection Biology". www.mpiib-berlin.mpg.de. ... The Systems Infection Biology Partner Group of Alex Sigal seeks to understand the persistence of HIV and tuberculosis ... The Vector Biology research unit is headed by Elena Levashina. It is studying the role mosquitoes play in regulating the ... "Vector Biology". www.mpiib-berlin.mpg.de. Retrieved 8 June 2020. "Innate Immune Regulation". www.mpiib-berlin.mpg.de. Retrieved ...
https://en.wikipedia.org/wiki/Max_Planck_Institute_for_Infection_Biology
Synthetic biologySynthetic biology
2012). "Designing biological systems: Systems Engineering meets Synthetic Biology". Chemical Engineering Science. 69 (1): 1-29 ... Schmidt M (June 2008). "Diffusion of synthetic biology: a challenge to biosafety" (PDF). Systems and Synthetic Biology. 2 (1-2 ... Kaznessis YN (November 2007). "Models for synthetic biology". BMC Systems Biology. 1 (1): 47. doi:10.1186/1752-0509-1-47. PMC ... "Communicating Synthetic Biology: from the lab via the media to the broader public". Systems and Synthetic Biology. 3 (1-4): 19- ...
https://en.wikipedia.org/wiki/Synthetic_biology
European Molecular Biology OrganizationEuropean Molecular Biology Organization
Aebersold, Ruedi (2005). "Molecular Systems Biology: A new journal for a new biology?". Molecular Systems Biology. 1: E1-E2. ... Molecular Systems Biology, EMBO Molecular Medicine, and Life Science Alliance, The European Molecular Biology Organization ( ... and European Molecular Biology Conference (EMBC) in European Molecular Biology (1970-1983)". Perspectives in Biology and ... Anon (2021). "The European Molecular Biology Conference (EMBC)". Retrieved 2021-04-28. Portals: Europe Biology (Articles with ...
https://en.wikipedia.org/wiki/European_Molecular_Biology_Organization
Agent-based model in biologyAgent-based model in biology
"Agent-based models in translational systems biology". Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1 (2): 159 ... Biological systems exhibit behavior that appears to be random. The probability of a particular behavior can be determined for a ... Metzcar J, Wang Y, Heiland R, Macklin P (February 2019). "A Review of Cell-Based Computational Modeling in Cancer Biology". JCO ... Agent-based models have many applications in biology, primarily due to the characteristics of the modeling method. Agent-based ...
https://en.wikipedia.org/wiki/Agent-based_model_in_biology
University of Freiburg Faculty of BiologyUniversity of Freiburg Faculty of Biology
"Welcome to FRISYS Freiburg Initiative for Systems Biology". Freiburg Initiative for Systems Biology. Retrieved June 15, 2012. " ... the Master of Science in biology and the Master of Science in Bioinformatics and Systems biology. The trinational, trilingual ... "Synthetic Biology (2009)". iGEM. Retrieved June 15, 2012. "Synthetic Biology (2010)". iGEM. Retrieved June 15, 2012. Ye, X; Al- ... which started operations in 2008 as offspring of the Freiburg Initiative for Systems Biology (FRISYS), funded by the Federal ...
https://en.wikipedia.org/wiki/University_of_Freiburg_Faculty_of_Biology
Monarch butterflyMonarch butterfly
"Sensory Systems". Biology. Monarch Watch. Archived from the original on March 19, 2018. Retrieved October 5, 2021. "Sexing ... The two possible explanations for this include that it promotes overall monarch health to boost the monarch's immune system or ... ISBN 978-0-618-12743-6. Ackery, P. R.; Vaine-Wright, R. I. (1984). Milkweed butterflies, their cladistics and biology: being an ... Reppert, Steven M (2018). "Demystifying monarch butterfly migration". Current Biology. 28 (17): R1009-R1022. doi:10.1016/j.cub. ...
https://en.wikipedia.org/wiki/Monarch_butterfly
Guimaras State UniversityGuimaras State University
Immunology Bachelor of Science in Marine Biology Bachelor of Science in Taxation Bachelor of Science in Wood Biology & ... a new system of education in the Philippines that allows learners to progress between Technical Vocational Education and ... Sustainability Systems Master of Professional Studies in Supply Chain Management Master of Psychology Master of Science in ... Bachelor of Science in Biology •Bachelor of Science in Chemistry •Bachelor of Science in Community Development •Bachelor of ...
https://en.wikipedia.org/wiki/Guimaras_State_University
Călin GeorgescuCălin Georgescu
A former Senior Fellow with the United Nations Development Programme, Georgescu also held various positions in the UN system, ... bio agriculture": Călin Georgescu, executive director of the National Centre for Sustainable Development"], interview by Sabina ... following 17 years of service in the environmental area in the United Nations system. Georgescu was appointed the executive ...
https://en.wikipedia.org/wiki/Călin_Georgescu
Atrioventricular nodeAtrioventricular node
The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical activity. A wave of excitation spreads ... Campbell, N., & Reece, J. (2002). Biology. 6th ed. San Francisco: Benjamin Cummings[page needed][ISBN missing] Gray, Huon H.; ... This property is important because loss of the conduction system before the AV node should still result in pacing of the ... Anatomy figure: 20:06-02 at Human Anatomy Online, SUNY Downstate Medical Center - "The conduction system of the heart." ...
https://en.wikipedia.org/wiki/Atrioventricular_node
Locus BiosciencesLocus Biosciences
Wright AV, Nuñez JK, Doudna JA (January 2016). "Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for ... Class 1 systems use a complex of multiple Cas proteins to degrade foreign nucleic acids. Class 2 systems use a single large Cas ... The 6 system types are divided into 19 subtypes. Many organisms contain multiple CRISPR-Cas systems suggesting that they are ... Co-founder, Rodolphe Barrangou, said "Cas3 is a meaner system...but if you want to cut a tree and get rid of it, you bring a ...
https://en.wikipedia.org/wiki/Locus_Biosciences
Mycoplasma incognitusMycoplasma incognitus
36(5): 1371-1377 Razin, Shmuel, Yogev, David and Naot, Yehudith (1998) Molecular Biology and Pathogenicity of Mycoplasmas ... which means that it can weaken the immune response by decreasing the ability of the immune system to produce antibodies. This ...
https://en.wikipedia.org/wiki/Mycoplasma_incognitus
SMS Tengku Muhammad Faris PetraSMS Tengku Muhammad Faris Petra
As a part of the enrolment process, students are sorted into the four main "Houses of Excellence" system, each bearing the name ... Faris Petra focuses predominantly on natural and pure science subjects such as Biology, Chemistry and Physics. However, a range ...
https://en.wikipedia.org/wiki/SMS_Tengku_Muhammad_Faris_Petra
Frank NeeseFrank Neese
He received both his Diploma (Biology - 1993) and Ph.D (1997) working with Peter M. Kroneck at the University of Konstanz. ... Neese, Frank (2012). "The ORCA program system". WIREs Computational Molecular Science. 2: 73-78. doi:10.1002/wcms.81. S2CID ...
https://en.wikipedia.org/wiki/Frank_Neese
Phage displayPhage display
A versatile screening system for selective isolation of genes by specific gene-product/ligand interaction". Eur. J. Biochem. ... Initial work was done by laboratories at the MRC Laboratory of Molecular Biology (Greg Winter and John McCafferty), the Scripps ... Like the two-hybrid system, phage display is used for the high-throughput screening of protein interactions. In the case of M13 ... cDNA has also been analyzed using pIII via a two complementary leucine zippers system, Direct Interaction Rescue or by adding ...
https://en.wikipedia.org/wiki/Phage_display
Connor QuerrardConnor Querrard
Assumption Greyhounds bio Connor Querrard at WorldFootball.net v t e (Soccerway template using numeric ID, NFT template with ID ... Querrard joined the youth national team system by playing with the national under-15 team. He played in the 2018 CONCACAF U-20 ...
https://en.wikipedia.org/wiki/Connor_Querrard
STS-47STS-47
Life sciences included experiments on human health, cell separation and biology, developmental biology, animal and human ... At the beginning of September, a problem with an oxygen line in the shuttle's main propulsion system was identified, however, ... a failure in the water system resulted in an unexpected rise of the humidity level in the experiment, which resulted in the ... sponsored by the Boy Scouts of America's Exploring Division in cooperation with the TRW Systems Integration Group, Fairfax, ...
https://en.wikipedia.org/wiki/STS-47
G1 phaseG1 phase
Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing ... G1/S transition Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J (2000). Molecular cell biology (4th ed.). ... Zetterberg A, Larsson O, Wiman KG (December 1995). "What is the restriction point?". Current Opinion in Cell Biology. 7 (6): ... Experimental Biology and Medicine. 234 (6): 639-50. doi:10.3181/0810-RM-300. PMID 19359655. S2CID 30323288. Ye Y, Wang H, Chu ...
https://en.wikipedia.org/wiki/G1_phase
Prostaglandin-endoperoxide synthase 2Prostaglandin-endoperoxide synthase 2
PTGS2 is linked with the inflammatory system and has been observed in inflammatory leukocytes. It has been noted that there is ... O'Banion MK (1999). "Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology". Crit Rev Neurobiol. 13 (1): 45-82. ...
https://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase_2
AssyriaAssyria
Through the ilku system, the Assyrian kings could also grant arable lands to individuals in exchange for goods and military ... Ashurbanipal's time however offer no evidence that foreigners were seen as racially or ethnically different in terms of biology ... Some regions of the Assyrian Empire were not incorporated into the provincial system but were still subjected to the rule of ... "Languages and Writing Systems in Assyria". In Frahm (2017). Mack, Jennifer (2017). The Construction of Equality: Syriac ...
https://en.wikipedia.org/wiki/Assyria
HutteritesHutterites
Human Biology. Vol. 66. JHU Press. pp. 411-20. ISBN 9780801870897. PMID 8026812. Colin Low. "The Hutterites by Colin Low - NFB ... In many colonies, telephones are tied into the sort of commercial private branch exchange (PBX) systems more commonly used by ... v. Montana Department of Labor and Industry, forced the Hutterites to participate in the workers' compensation system despite ... Canada, Parliament, Senate, "Evidence: Study on the present state of the domestic & international financial system," ...
https://en.wikipedia.org/wiki/Hutterites
New Delhi metallo-beta-lactamase 1New Delhi metallo-beta-lactamase 1
Other tests for phenotypic detection are: Double disk synergy testing (DDST) Vitek detection (Automated system) E-test (E-Strip ... PBS Frontline Oct 22, 2013 Hunting the Nightmare Bacteria Portal: Biology (CS1 French-language sources (fr), CS1 Croatian- ... The authors warned that international travel and patients' use of multiple countries' healthcare systems could lead to the " ... Physicians of India blamed the emergence of this gene on the widespread misuse of antibiotics in the Indian healthcare system, ...
https://en.wikipedia.org/wiki/New_Delhi_metallo-beta-lactamase_1
Cervical cancerCervical cancer
However, the current system allows use of any imaging or pathological methods for staging. Stage 1A cervical cancer Stage 1B ... and Reproductive Biology. 121 (1): 99-103. doi:10.1016/j.ejogrb.2004.11.024. PMID 15949888. Jensen KE, Schmiedel S, Frederiksen ... 1988: Bethesda System for reporting Pap results was developed. 2006: First HPV vaccine was approved by the FDA. 2015: HPV ... Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many ...
https://en.wikipedia.org/wiki/Cervical_cancer
Human geographyHuman geography
Much of the development during the quantitative revolution is now apparent in the use of geographic information systems; the ... and has close links to the field of evolutionary biology of the time. Environmental determinism is the theory that people's ... Economic geography examines relationships between human economic systems, states, and other factors, and the biophysical ...
https://en.wikipedia.org/wiki/Human_geography
Black genocideBlack genocide
People who live in poor areas are more suspicious of the health care system, and as a result, they may reject medical treatment ... Human Biology. Special Issue Section: Latin American Anthropometrics. 8 (2): 261-272. doi:10.1016/j.ehb.2010.01.002. ISSN 1570- ... It states that "The public school system in the United States, like the country as a whole, is plagued by vast inequalities- ... However, Selective Service System deferments, military assignments, and especially the recruits accepted through Project ...
https://en.wikipedia.org/wiki/Black_genocide
Alexei UkhtomskyAlexei Ukhtomsky
He died 31 August 1942, without having read the proofs of a report titled "The system of reflexes in ascending order.", which ... He was head of the biology department at Leningrad University, from 1931 until 1938 he was president of the Leningrad Society ... while in the rest of the central nervous system inhibition spreads widely. " The theory of the dominant focus has outgrown the ... the dominant is a temporary governing center of excitation in the central nervous system, which creates a hidden readiness of ...
https://en.wikipedia.org/wiki/Alexei_Ukhtomsky
DinocarididaDinocaridida
Current Biology. 32 (15): 3302-3316.e2. doi:10.1016/j.cub.2022.06.027. ISSN 0960-9822. PMID 35809569. Van Roy, Peter; Daley, ... "Sophisticated digestive systems in early arthropods". Nature Communications. 5 (1): 3641. Bibcode:2014NatCo...5.3641V. doi: ... Current Biology. 25 (12): 1625-1631. doi:10.1016/j.cub.2015.04.034. ISSN 0960-9822. PMID 25959966. Briggs, Derek E. G.; Nedin, ... Journal of Theoretical Biology. 238 (1): 11-17. Bibcode:2006JThBi.238...11U. doi:10.1016/j.jtbi.2005.05.008. PMID 16002096. ...
https://en.wikipedia.org/wiki/Dinocaridida
PLATO (computer system)PLATO (computer system)
... conceived in 1967 by biology graduate student Paul Tenczar. Built on a CDC 1604, given to them by William Norris, PLATO III ... the last system that ran the PLATO software system on a CDC Cyber mainframe, from active duty. Existing PLATO-like systems now ... The underlying operating system is NOS 2.8.7, the final release of the NOS operating system, by permission of Syntegra (now ... An attempt to mass-market the PLATO system was introduced in 1980 as Micro-PLATO, which ran the basic TUTOR system on a CDC " ...
https://en.wikipedia.org/wiki/PLATO_(computer_system)
Eliot A. CohenEliot A. Cohen
"Cohen's Bio on the Johns Hopkins University website". Archived from the original on 2005-12-15. Retrieved 2006-04-10. "Eliot ... Cohen, Eliot Asher (1984). "Systems of Military Service". Archived from the original on 2021-10-09. Retrieved 2021-09-17. "Vali ...
https://en.wikipedia.org/wiki/Eliot_A._Cohen
DJ Kool HercDJ Kool Herc
Herc's first sound system consisted of two turntables connected to two amplifiers and a Shure "Vocal Master" PA system with two ... Kool Herc discography at Discogs DJ Kool Herc at IMDb A biography of DJ Kool Herc at OldSchoolHipHop.com Lengthy Kool Herc bio ... While growing up, he saw and heard the sound systems of neighborhood parties called dance halls, and the accompanying speech of ...
https://en.wikipedia.org/wiki/DJ_Kool_Herc
PANO1PANO1
"Phyre 2 Results for PANO1_phyre2". www.sbg.bio.ic.ac.uk. Retrieved 2021-08-01. "Genomatix Software Suite". Genomatix.{{cite web ... analysis of these types of genes revealed that they often have tissue-specific expression in tissues such as the nervous system ...
https://en.wikipedia.org/wiki/PANO1
National Pedagogical Drahomanov UniversityNational Pedagogical Drahomanov University
In 1933, biological and geographical divisions were opened, which were later reorganized as Biology and Chemistry and Geography ... history of educational systems and technologies and applied psychology and psychotherapy. Dean - PhD in Philological Science, ... ", "System analysis in management", "Analytics in management". Dean - Honored Artist of Ukraine, Doctor of Pedagogical Sciences ... biology and geography began in the 1920s. ...
https://en.wikipedia.org/wiki/National_Pedagogical_Drahomanov_University
MultimethodologyMultimethodology
The terms methodology and biology share a common suffix "logy." Just as bio-logy is a discourse about life - all kinds of life ... Pragmatism allows for the integration of qualitative and quantitative methods as loosely coupled systems to support mixed ... It seems unproductive, therefore, to speak of multi-biologies or of multi-methodologies. It is very productive, however, to ... Pragmatism reconciles these differences an integrates quantitative and qualitative research as loosely coupled systems, where " ...
https://en.wikipedia.org/wiki/Multimethodology
List of restriction enzyme cutting sites: Bst-BvList of restriction enzyme cutting sites: Bst-Bv
A suggested nomenclature for bacterial host modification and restriction systems and their enzymes". J. Mol. Biol. 81 (3): 419- ... Molecular-biology-related lists, Restriction enzymes). ...
https://en.wikipedia.org/wiki/List_of_restriction_enzyme_cutting_sites:_Bst–Bv
Adonten Senior High SchoolAdonten Senior High School
However, in 1963, the Ministry of Education took charge of the school and changed it into the public system as a day secondary ... 3 Science Laboratories ( Physics, Biology and Chemistry) I.C.T Lab Library Home Economics Lab Visual Arts Center School Farm ... The school runs both day, boarding and hostel system with majority of the students in the boarding house. The school has about ...
https://en.wikipedia.org/wiki/Adonten_Senior_High_School
Walter T. Kerwin Jr.Walter T. Kerwin Jr.
Recognized by his commanders and peers as an innovative artilleryman, Kerwin developed a system of massing fires that ... World War II portal 2003 Distinguished Graduate Award bio [1] (Articles with short description, Short description is different ...
https://en.wikipedia.org/wiki/Walter_T._Kerwin_Jr.
Sarah Ann DouglasSarah Ann Douglas
Upon returning to the United States, she worked as a professional programmer, systems analyst, Director of Software Development ... Developmental Biology. 8 (5): 477-488. doi:10.1006/scdb.1997.0173. PMID 9441953. Retrieved 10 November 2017. Douglas, Sarah A ... as a reviewer for ACM Transactions on Computer-Human Interaction and the ACM Conference on Human Factors in Computing Systems. ... and Director at Computing Systems at Cabrillo College and San Jose State University in California. She returned to graduate ...
https://en.wikipedia.org/wiki/Sarah_Ann_Douglas
Systems biology of the autophagy-lysosomal pathwaySystems biology of the autophagy-lysosomal pathway
... Autophagy. 2011 May;7(5):477-89. doi: 10.4161/auto.7.5.14811. Epub 2011 May ... We performed a systems biology-based integrative computational analysis to study the interactions between molecular components ... Overall this study demonstrates the utility of systems biology-based approaches for understanding the autophagy-lysosomal ... the mouse knockout phenotype data for the autophagylysosomal genes and found them to be highly predictive of nervous system ...
https://pubmed.ncbi.nlm.nih.gov/21293178/
Software - Bioinformatics and Systems BiologySoftware - Bioinformatics and Systems Biology
... and extended in the future to build a comprehensive bioinformatics technology platform for genome based systems biology. ...
https://www.uni-giessen.de/de/fbz/fb08/Inst/bioinformatik/software/index?set_language=de
Computational and Systems Biology at MITComputational and Systems Biology at MIT
... This video was recorded at MIT Industrial Liaison Program. Once the young field of ... You just viewed Computational and Systems Biology at.... Please take a moment to rate this material. ... systems biology really picks up steam, there will be reams of difficult new data to sort through, warns Peter Sorger. As ... away from the heavily structured information of gene-protein sequencing to analyzing the dizzyingly complex links among systems ...
https://merlot.org/merlot/viewMaterial.htm?id=973156
Systems Biology Digs Deep, Aims HighSystems Biology Digs Deep, Aims High
The interconnected systems behind disease processes are being unraveled by systems biology, a discipline that integrates life ... At Weill Cornell Medical College, the laboratory of Olivier Elemento, Ph.D., combines computational biology and systems biology ... The Interconnected Systems behind Disease Processes Are Being Unraveled By Systems Biology ... Elemento, "relies on using a combination of computational biology and systems biology." ...
https://www.genengnews.com/magazine/273/systems-biology-digs-deep-aims-high/
Systems Oncology: Toward the Clinical Application of Cancer Systems BiologySystems Oncology: Toward the Clinical Application of Cancer Systems Biology
Learn how systems oncology will revolutionize the consulting rooms of oncologists worldwide. ... The application of systems biology to the study of cancer has been termed cancer systems biology.[4] ... Systems Oncology: Toward the Clinical Application of Cancer Systems Biology. Manuel Valladares-Ayerbes; Mar Haz-Conde; Moisés ... Systems biology employs methodological approaches based on mathematics and bioinformatics to construct complex systems (or ...
https://www.medscape.com/viewarticle/840042
Frontiers in Systems Biology | Multiscale Mechanistic ModelingFrontiers in Systems Biology | Multiscale Mechanistic Modeling
Emerging Talents in Systems Biology: Multiscale Mechanistic Modeling 2022. *Panayiotis V. Benos ... Systems Biology, Women in Science 2021/22: Multiscale Mechanistic Modeling. *Helen Byrne ... Integration of Multi-Scale Omics Data and Network Biology Approaches for Deciphering Complex Human Disorders and Disease. *Asim ... Integrating the Hierarchical Interaction Network with machine learning and multi-omic data for Systems-level understanding. * ...
https://www.frontiersin.org/journals/systems-biology/sections/multiscale-mechanistic-modeling/research-topics
UFS Evolutionary Systems Biology - University of PotsdamUFS Evolutionary Systems Biology - University of Potsdam
Systems Biology at the University of Potsdam acts at the interface between evolutionary biology and systems biology - two well- ... Both evolutionary biology and systems biology are firmly grounded in mathematical modelling and development of theories, ... Conceptual and methodological connections between evolutionary biology and systems biology: Mutations, natural selection, and ... systems biology aims at understanding how interactions of cellular components within biological systems lead to emergent ...
https://www.uni-potsdam.de/en/esb/
Systems and synthetic biology - SINTEFSystems and synthetic biology - SINTEF
... develop them into efficient microbial cell factories by means of metabolic engineering and applying top-down Synthetic Biology ... SINTEF Materials and Chemistry is coordinating and participating projects aiming at systems scale understanding of microbial ... Infrastructure platforms of relevance for Systems Biology and Synthetic Biology. Molecular Biology, Advanced Analytics, HTS, ... Model systems we worked extensively with in recent years at systems biology level are the methylotrophic bacterium Bacillus ...
https://www.sintef.no/en/expertise/sintef-industry/biotechnology-and-nanomedicine/systems-and-synthetic-biology/
Biology : Skeletal System & Bones of Human Body II - Match the ColumnsBiology : Skeletal System & Bones of Human Body II - Match the Columns
Biology : Skeletal System & Bones of Human Body II. Given the SKELETAL POSITION, identify the BONE NAME. .maintabs td { text- ... NY Regents Exam Teasers IQ Tests Chemistry Biology GK C++ Recipes Search < a href="/cgi/members/home.cgi" class="toplink"> ...
https://www.syvum.com/cgi/online/mtc.cgi/squizzes/biology/human_skeleton_2.tdf?0
dblp: Intelligent Systems in Molecular Biologydblp: Intelligent Systems in Molecular Biology
Bibliographic content of Intelligent Systems in Molecular Biology ... Conference on Intelligent Systems for Molecular Biology/Third ... Proceedings of the 1st International Conference on Intelligent Systems for Molecular Biology, Bethesda, MD, USA, July 1993. ... Proceedings of the Fourth International Conference on Intelligent Systems for Molecular Biology, St. Louis, MO, USA, June 12-15 ... Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, August 19-23, 2000, La Jolla ...
https://dblp.uni-trier.de/db/conf/ismb/index.html
PDF] Complex systems biology | Semantic ScholarPDF] Complex systems biology | Semantic Scholar
... technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, ... Considering concepts of complex systems theory in systems biology can illuminate our overall understanding of normal cell ... and the human cell is described as a prototypical complex system. Complex systems theory is concerned with identifying and ... However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I ...
https://www.semanticscholar.org/paper/Complex-systems-biology-Ma%E2%80%99ayan/4e0671666a4e6b7cf4136ea04894e4b45842bdab?p2df
Biology : Human Endocrine System - Worksheet / Test PaperBiology : Human Endocrine System - Worksheet / Test Paper
Biology quizzes & activities on cells, human organ systems, botany, zoology and other topics ... FREE online interactive quizzes on human endocrine system, ... NY Regents Exam Teasers IQ Tests Chemistry Biology GK C++ ...
https://www.syvum.com/cgi/online/serve.cgi/squizzes/biology/endo.html?question_hide
Webinars | Institute of Systems BiologyWebinars | Institute of Systems Biology
Institute of Systems Biology (INBIOSIS). Universiti Kebangsaan Malaysia. 43600 UKM Bangi, Selangor Malaysia ... Bioinformatics: An Integral Part of Systems Biology That Accelerates Translational Biotechnology. Ts. Dr. Nor Azlan Nor ... Virus Structure and Opportunities of Structural Biology at NSRRC. Prof. Dr. Chun-Jung Chen. National Synchrotron Radiation ... Industrial strain optimization for production of molecules for the skin bio industry. Dr. Cuauhtémoc Licona Cassani. ...
https://www.ukm.my/inbiosis/en/webinars/
Home - RNA Systems Biology - IITHome - RNA Systems Biology - IIT
Elias Bechara Researcher RNA Systems Biology Alessandra Galati Technician Nanotechnologies for Neurosciences Non coding RNAs in ... Magdalena Arnal Segura PhD Student RNA Systems Biology Eva Ferri Administrative Assistant Non-coding RNAs and RNA-based ... RNA Systems Biology Andrea Daiello Administrative Supervisor Neuroscience and Behaviour Nanotechnologies for Neurosciences ... RNA Systems Biology Procurement Directorate Res. Line Admin. Support Life Science Neuroscience of Perception and Action ...
https://www.iit.it/it/web/rna-systems-biology
permalinkpermalink
Applying systems biology to validate prescientific quackery is tooth fairy science * facebook ... A systems biology map of woo masquerading as pharmacognosy. Its not important that you know exactly what this chart means. All ... entitled To Unveil the Molecular Mechanisms of Qi and Blood through Systems Biology-Based Investigation into Si-Jun-Zi-Tang and ... Both are TCM diagnoses, not diagnoses that have anything to do with biology or medical reality, given that qi is a term to ...
https://www.scienceblogs.com/insolence/2016/10/26/applying-systems-biology-to-validate-prescientific-quackery
Systems Biology PortalSystems Biology Portal
Features: Intuitive User Interface Display Species and Compartments in color Extensive Notes Description (to Com ...
https://www.systems-biology.org/2004/09/
COVID-19 | Molecular Systems Biology | University of HelsinkiCOVID-19 | Molecular Systems Biology | University of Helsinki
Our lab developed a Gateway®-compatible MAC (Multiple Approaches Combined) -tag system that allows an easy way to probe the ... The aim of our project is applying MAC-tag system to construct a comprehensive virus-host protein interaction network, which ...
https://www.helsinki.fi/en/researchgroups/molecular-systems-biology/research/covid-19
Free Biology Flashcards about Nervous SystemFree Biology Flashcards about Nervous System
Study free Biology flashcards about Nervous System created by kmaddix to improve your grades. Matching game, word search puzzle ... Nervous System. Term. Definition. Nervous system. the network of nerve cells and fibers that transmits nerve impulses between ... central nervous system. brain and spinal cord. peripheral nervous system. the sensory and motor neurons that connect the ... somatic nervous system. the division of the peripheral nervous system that controls the bodys skeletal muscles. ...
https://www.studystack.com/flashcard-2696947
Deconstructionist Derrida Bequeaths $10M to Fund Yale Systems Biology Institute | GenomeWebDeconstructionist Derrida Bequeaths $10M to Fund Yale Systems Biology Institute | GenomeWeb
for Postmodern Systems Biology, will be the first of its kind to be headed by a non-scientist. It also marks the first time ... "This will expand the range of problems addressed by systems biology," he said, "which, as everyone knows, has failed to ... NEW YORK, April 1 (GenomeWeb News) - Seeking to expand systems biology beyond what it calls "the rigid confines of its ... "Who says no one but scientists and engineers can contribute to the progress of systems biology?" said Carlos Jacobin, professor ...
https://www.genomeweb.com/archive/deconstructionist-derrida-bequeaths-10m-fund-yale-systems-biology-institute
Systems Biology Group MeetingSystems Biology Group Meeting
Center for Computational Biology Center for Computational Biology. *Center for Computational Biology ... Systems Biology Group Meeting on Simons Foundation ...
https://www.simonsfoundation.org/event/systems-biology-group-meeting-17/2021-09-27/
Advisory Board Member Bio | Security Systems NewsAdvisory Board Member Bio | Security Systems News
He continued with electronic systems training as a missile technician in the United States Navy from 1985-1993, during which ... 2023 Security Systems News. All rights reserved. Web solutions provided by VGM Forbin ... 2023 Security Systems News. All rights reserved. Web solutions provided by VGM Forbin ...
https://www.securitysystemsnews.com/advisory-board/andrew-lanning
Strength in numbers: Collaborative science for new experimental model systems | PLOS BiologyStrength in numbers: Collaborative science for new experimental model systems | PLOS Biology
... and this limits our ability to explore the molecular mechanisms that ultimately define their biology, ecology, and diversity. ... Our current understanding of biology is heavily based on a small number of genetically tractable model organisms. Most ... Marine biology Is the Subject Area "Marine biology" applicable to this article? Yes. No. ... PLOS Biology provides an Open Access platform to showcase your best research and commentary across all areas of biological ...
https://journals.plos.org/plosbiology/article?rev=1&id=10.1371/journal.pbio.2006333
BSBC Servers | Bioinformatics and Systems Biology Core | University of Nebraska Medical Center
Bioinformatics and Systems Biology Core server for UNMC bioinformatics research. Intel(R) Xeon(R) CPU E7- 8850 @ 2.00GHz, 160 ... UNMC Bioinformatics and Systems Biology Core Servers ... UNMC › Bioinformatics and Systems Biology Core › Services › ... UNMC Bioinformatics and Systems Biology Core Servers ...
https://www.unmc.edu/bsbc/services/resources/servers.html
François Jacob Institute of biology - SysFate - Systems Biology of cell Fate decisionsFrançois Jacob Institute of biology - SysFate - Systems Biology of cell Fate decisions
You are here : Home , Research Centers and Units , Genoscope , UMR8030 , SysFate - Systems Biology of cell Fate decisions ... The François Jacob Institute of Biology brings together five departments and three services ... Laboratory of Systems & Synthetic Biology (LISSB). DossierSysFate - Systems Biology of cell Fate decisions. ...
https://www.cea.fr/drf/ifrancoisjacob/english/Pages/Departments/Genoscope/Laboratories/UMR_8030/LISSB/SysFate.aspx
Publications | Systems Chrono (Biology + Medicine)Publications | Systems Chrono (Biology + Medicine)
Stochastic growth reduces population fluctuations in Daphnia-algal systems. Ecology. DOI ...
https://itb.biologie.hu-berlin.de/~bharath/publication/
Fillerina Bio-Revitalizing Plumping System - 932 - Dermstore Fillerina Bio-Revitalizing Plumping System - 932 - Dermstore
BuyFillerina Bio-Revitalizing Plumping System - 932online with Dermstore. We have a great range ofproducts available. ... This Mask System is for all ages of skin and will heal, repair and plump the skin. ... This Mask System is for all ages of skin and will heal, repair and plump the skin. ...
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General Biology/Tissues and Systems/Homeostasis - Wikibooks, open books for an open worldGeneral Biology/Tissues and Systems/Homeostasis - Wikibooks, open books for an open world
General Biology , Getting Started , Cells , Genetics , Classification , Evolution , Tissues & Systems , Additional Material ... General Biology , Getting Started , Cells , Genetics , Classification , Evolution , Tissues & Systems , Additional Material ... General Biology/Tissues and Systems/Homeostasis. From Wikibooks, open books for an open world ... Retrieved from "https://en.wikibooks.org/w/index.php?title=General_Biology/Tissues_and_Systems/Homeostasis&oldid=3803328" ...
https://en.wikibooks.org/wiki/General_Biology/Tissues_and_Systems/Homeostasis
7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System | Biology7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System | Biology
7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System , Biology The mammalian brain easily ... Other materials like 7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System , Biology ... Edit comment for material 7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System , Biology ... Material Detail: 7.340 Learning and Memory: Activity-Controlled Gene Expression in the Nervous System , Biology ...
https://www.merlot.org/merlot/viewMaterial.htm?id=1162564
Corporate Action | Boston Bio Systems (BOSTONBIO) Company - Business Standard NewsCorporate Action | Boston Bio Systems (BOSTONBIO) Company - Business Standard News
Boston Bio Systems (BOSTONBIO) - Business Standard News and more from Business Standard News ... Boston Bio Systems Ltd. (BOSTONBIO) - Corporate Action. Search Purpose:. Book Closure. Board Meeting. AGM. EGM. Dividend. Bonus ... Quick Links for Boston Bio Systems:. * News. Announcements Brokerage Reports Business Earnings Sector ...
https://www.business-standard.com/company/boston-bio-5759/corporate-action?purpose=egm
SELECTBIO - Systems Biology Europe Business CoursesSELECTBIO - Systems Biology Europe Business Courses
Systems Biology Europe. Systems Biology Europe in Madrid, Spain. Madrid, Spain. SELECTBIO. [email protected] ...
http://selectbiosciences.com/conferences/businesstutorials.aspx?pid=1324&conf=SBE2012
ApproachesAviva Systems BiologyBiological systemsBiochemistrySyntheticDisciplinesPharmacologyPLOS BiologyPathwaysSearchLiving organismsImmune systemSynthesisMathematicalEvolutionary biologyCellularTissuesPathological conditionsGenome-wideInteractionsCentreResearchInstituteInsightsIntegrativeMethodologiesDynamicalClinicalMolecular systemsComputational methodsEmergent propertiesDevelopmentalEpidemiologyNervousModern biologyStudySciencesMechanisms2016PerturbationsUniversity
Approaches16
  • Overall this study demonstrates the utility of systems biology-based approaches for understanding the autophagy-lysosomal pathways and gaining additional insights into the potential impact of defects in these complex biological processes. (nih.gov)
  • Advances in molecular and imaging approaches have helped dissect the individual components of signaling pathways and visualize their structural and functional details, and they have been instrumental for characterizing networks and for advancing system biology. (genengnews.com)
  • Both evolutionary biology and systems biology are firmly grounded in mathematical modelling and development of theories, resulting in novel cutting-edge computational approaches. (uni-potsdam.de)
  • The aim is to develop them into efficient microbial cell factories by means of metabolic engineering and applying top-down Synthetic Biology and metabolic engineering approaches. (sintef.no)
  • Strain development using top-down Synthetic Biology approaches and metabolic engineering, guided by systems scale understanding of microbial chassis organisms. (sintef.no)
  • This review has documented the passage of SARS‐CoV‐2 from infection of a single cell to species jump, to tropism, variant emergence and widespread population infection, and used systems analysis approaches with human physiology and pharmacology to explore the fundamental underpinnings of COVID‐19 disease. (semanticscholar.org)
  • Systems biology employs methodological approaches based on mathematics and bioinformatics to construct complex systems (or models) incorporating multiple data inputs. (medscape.com)
  • Our lab developed a Gateway®-compatible MAC (Multiple Approaches Combined) -tag system that allows an easy way to probe the molecular level localization and interaction of protein of interest. (helsinki.fi)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. (cshlpress.com)
  • Here, we introduce the concept of using design approaches and molecular tools applied in synthetic biology for the construction of interconnected biohybrid materials systems with information processing functionality. (materialstoday.com)
  • We are utilising a number of approaches to understand how nanomaterials interact with biological systems. (liverpool.ac.uk)
  • By employing genome-wide epigenomic and systems biology approaches, PM toxicogenomics could conceivably progress greatly with the potential identification of individual epigenetic loci associated with dysregulated gene expression after PM exposure, as well the interactions between epigenetic pathways and PM. Furthermore, novel therapeutic targets based on epigenetic markers could be identified through future epigenomic studies on PM-mediated cardiopulmonary toxicities. (uic.edu)
  • and discusses these approaches' performance in a detection evaluation exercise conducted in 2003 by the Bio-Event Advanced Leading Indicator Recognition Technology (Bio-ALIRT) program of the Defense Advanced Research Project Agency (DARPA) ( 2 ). (cdc.gov)
  • Exploiting the natural product potential of fungi with integrated-omics and synthetic biology approaches. (purdue.edu)
  • This included functional genomics and systems biology approaches to study antimicrobial resistance, MERS and SARS coronaviruses, influenza viruses, and Ebola and Zika viruses. (cdc.gov)
  • Key findings include substantial efforts in broadening the number and types of HIV surveillance components included in national HIV surveillance systems and adopting approaches to make surveillance more cost-efficient, such as integrating routine programme monitoring data and passive surveillance case reporting systems. (who.int)
Aviva Systems Biology2
  • Aviva Systems Biology is a team-oriented organization represented by highly dedicated and talented people. (avivasysbio.com)
  • This is a synthetic peptide designed for use in combination with anti-TMBIM4 Antibody (ARP66969_P050), made by Aviva Systems Biology. (absave.com)
Biological systems7
  • While evolutionary biology focuses on understanding how heritable traits change in populations due to mutation, natural selection, drift and migration, systems biology aims at understanding how interactions of cellular components within biological systems lead to emergent properties over the lifespan of a single individual. (uni-potsdam.de)
  • Anti-GMO activists counter that GMOs are unsafe since substantial equivalence is unscientific and outdated since it originates in the 1970s to assess safety of medical devices, which are not comparable to the complexity of biological systems, and contend that targeted GM is not plant breeding. (scirp.org)
  • Biological systems, from proteins to living cells and organisms, obey physical principles. (tum.de)
  • To do this, we investigate the molecular connections that keep biological systems in balance. (idw-online.de)
  • With the help of computer-assisted, bioinformatic methods, they identify those factors that cause biological systems to become unbalanced - and thus lead to diseases. (idw-online.de)
  • Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. (bvsalud.org)
  • Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems. (bvsalud.org)
Biochemistry3
  • With the advent of the new century, the development of high-throughput technologies for biological analyses, in particular for biochemistry and molecular biology, made possible the generation of a huge amount of data from multiple sources (i.e., isolated cells, body fluids, tissues and so on) at multiple molecular levels (i.e., genomic, transcriptomic, proteomic and so on). (medscape.com)
  • This issue of Essays in Biochemistry provides an overview of current research at the interface of the disciplines of biochemistry and systems biology and also looks ahead to future interactions. (portlandpress.com)
  • The biological sciences, or the life sciences, encompass a broad spectrum of subjects from molecular biology to ecology as well as such disciplines as biochemistry, biophysics, genetics and physiology. (brocku.ca)
Synthetic7
  • Synthetic biology involves the rational design and construction of biological components and systems from genetic elements and metabolic pathways to entirely new organisms. (cshlpress.com)
  • In summary, this volume would be very useful to any advanced student or researcher planning on running a synthetic biology project: a few focused hours with the book could save months of frustration at the bench. (cshlpress.com)
  • Synthetic biology applies engineering concepts to build cells that perceive and process information. (materialstoday.com)
  • The modular design concept presented here thus represents a blueprint for integrating synthetic biology-inspired information-processing circuits into polymer materials. (materialstoday.com)
  • Other topics include the development of computational models for root and shoot growth, as well as chemical tools and synthetic systems to understand auxin biology. (cshlpress.com)
  • For this reason, I am developing a set of molecular tools that will allow us to engineer these fungal genomes and, ultimately, these synthetic biology tools will allow us to control the expression of the BGCs for antibiotic and pharmaceutical purposes. (purdue.edu)
  • Seminar on Current Topics in Synthetic Bio-Systems for M.Sc. (tum.de)
Disciplines2
  • The priority research area Evolutionary Systems Biology at the University of Potsdam acts at the interface between evolutionary biology and systems biology - two well-established disciplines in biology. (uni-potsdam.de)
  • NEW YORK, April 1 (GenomeWeb News) - Seeking to expand systems biology beyond what it calls "the rigid confines of its traditional disciplines," Yale University will create a new systems-biology institute funded by a bequest from Jacques Derrida, the noted French intellectual who died last October. (genomeweb.com)
Pharmacology2
  • Dr. Elemento heads a laboratory that focuses on identifying the cellular targets of small molecules, a task of critical importance for molecular biology, pharmacology, and drug design. (genengnews.com)
  • In recent years, the systems biology framework has enabled research in quantitative and systems pharmacology and precision medicine for complex diseases. (portlandpress.com)
PLOS Biology1
  • PLOS Biology provides an Open Access platform to showcase your best research and commentary across all areas of biological science. (plos.org)
Pathways3
  • Interaction of nanomaterials with the human immunological & haematological systems , pathways of cellular uptake of nanoparticles (both receptor and non-receptor mediated), nanotoxicity of nanomaterials and interaction of nanoparticles with plasma proteins (biomolecular corona). (liverpool.ac.uk)
  • Systems biology uses a wide range of quantitative experimental and computational methodologies to decode information flow from genes, proteins and other subcellular components of signaling, regulatory and functional pathways to control cell, tissue, organ and organismal level functions. (portlandpress.com)
  • The initiation and propagation of procoagulant pathways, with simultaneous impairment of natural anticoagulant systems and suppression of endogenous fibrinolysis as a result of systemic inflammatory activation, lead to platelet activation and fibrin deposition. (medscape.com)
Search1
  • The results of surveys, analyses, and studies are made known through a number of data release mechanisms including publications, mainframe computer data files, CD-ROMs (Search and Retrieval Software, Statistical Export and Tabulation System (SETS)), and the Internet (http://www.cdc.gov/nchswww/nchshome.htm). (cdc.gov)
Living organisms1
  • As scientists move away from the heavily structured information of gene-protein sequencing to analyzing the dizzyingly complex links among systems in living organisms, they'll need better tools. (merlot.org)
Immune system4
  • Many nanomaterials have been shown to interact with the immune system by either stimulating or suppressing various responses through their interaction with proteins found within blood. (liverpool.ac.uk)
  • In experiments with laboratory mice, the research team realised that this is indeed the case: if you administer mesaconic acid to mice whose immune system is currently 'overshooting', i.e. showing too strong a defence reaction, the mice quickly get better. (idw-online.de)
  • We now need to investigate why mesaconic acid has a positive anti-inflammatory effect on the immune system', says He. (idw-online.de)
  • Mesaconic acid could be considered as an active agent against diseases in which the immune system is too strongly activated - in septic shock and especially also autoimmune diseases such as psoriasis or inflammatory bowel disease', says Professor Hiller. (idw-online.de)
Synthesis2
  • In Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems , pages 321-328, MIT Press, 2008. (panmental.de)
  • In Artificial Life X: Proceedings of the Tenth International Conference on the Simulation and Synthesis of Living Systems , pages 15-21, MIT Press/Bradford Books, 2006. (panmental.de)
Mathematical3
  • It is also about using mathematical and computational modeling to make predictions about the system. (genengnews.com)
  • This project was devoted to the mathematical analysis of ODE models arising in cell biology. (europa.eu)
  • Guided by a quantitative mathematical model, we next interconnect these materials into a materials system that acts as both a signal detector and as an amplifier based on a built-in positive feedback loop. (materialstoday.com)
Evolutionary biology1
  • The Hardy-Weinberg law, a seminal theoretical result in evolutionary biology, states that in absense of these driving forces and without migration the genotype and allele frequences in a population remain constant. (uni-potsdam.de)
Cellular6
  • Biotechnology, molecular biology, and genetic engineering share a firm foundation-a massive body of knowledge about individual cellular and subcellular components. (genengnews.com)
  • Historically, most systems biology efforts have focused on generating models at the cellular level to provide a better understanding of intracellular processes. (genengnews.com)
  • Systems biology focuses on cellular networks in an individual by employing phenotyping technologies across different temporal and spacial scales. (uni-potsdam.de)
  • The aim of our project is applying MAC-tag system to construct a comprehensive virus-host protein interaction network, which can be used to identify the cellular functions that are mandatory for viral replication and to develop host-targeting antivirals strategies against SARS-CoV-2. (helsinki.fi)
  • Researchers everywhere are being forced to acknowledge that cellular systems operate within larger rhetorical systems," said Marsha Gersten, a Yale bioinformaticist who will be joining the new Center. (genomeweb.com)
  • Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered. (cshlpress.com)
Tissues2
  • Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and organismal phenotypes through quantitative reasoning, computational models and high-throughput experimental technologies. (portlandpress.com)
  • The computational methods used in systems biology provide systems-level insights to understand interactions and dynamics at various scales, within cells, tissues, organs and organisms. (portlandpress.com)
Pathological conditions1
  • Systems biology is an emerging discipline that pursues the integration of multiple levels of biological information in order to attain an integral view and deep understanding of physiological processes both in healthy and pathological conditions. (medscape.com)
Genome-wide1
  • The SBU collaborates closely with other core facilities, such as the Genome Biology Unit (GBU) that provides genome-wide reagents and technology services. (helsinki.fi)
Interactions3
  • We performed a systems biology-based integrative computational analysis to study the interactions between molecular components and to develop models for regulation and function of genes involved in autophagy and lysosomal function. (nih.gov)
  • For prediction of protein-protein interactions, we improved our MIRRORTREE system for co-evolution-based prediction of protein interaction partners in a number of ways. (csic.es)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Centre2
  • A team of scientists led by Professor Karsten Hiller from the Braunschweig Centre for Systems Biology BRICS has discovered an endogenous, anti-inflammatory substance: mesaconic acid. (idw-online.de)
  • At the Braunschweig Centre for Systems Biology, the BRICS, researchers aim to understand what health means. (idw-online.de)
Research14
  • Started in late 2020, the Webinar Series has brought about a new platform and opportunity for everyone connected to INBIOSIS UKM to learn fascinating R&D development and current research trends by local and international researchers in the fields of molecular biology and biotechnology. (ukm.my)
  • In our group, the research is highly interdisciplinary, involves a number of international collaborators and focuses on structural biology and the uncharted territory of non-coding RNAs involved in transcriptional and translational regulation (e.g. (iit.it)
  • The project advanced multidisciplinary research at the boundary of mathematics and modelling in cell biology. (europa.eu)
  • From the Systems Biology perspective we consider the concept of "Software as a Medical Device" and what this may imply for the migration of research-oriented, simulation software into the domain of human health. (medworm.com)
  • As integrated sensors and actuators, the resulting smart materials systems could provide novel solutions with broad perspectives in research and development. (materialstoday.com)
  • R&D Systems has been setting the standard in quality research reagents for over 30 years. (rndsystems.com)
  • Ziva Ramsak currently works at the Department of Biotechnology and Systems Biology, National Institute of Biology - Ziva does research in Systems Biology, Biostatistics and Bioinformatics. (researchgate.net)
  • 2 years of data records from a system-evaluation exercise for the Defense Advanced Research Project Agency (DARPA). (cdc.gov)
  • Once I was introduced to the lab research setting, however, I realized that I could have an equally impactful contribution to the medical field through my passion for biology and chemistry. (purdue.edu)
  • One-time award for graduate students to research the biology, ecology, management, and education about the common loon and its habitat. (internationalscholarships.com)
  • With this RII C2 award, Alabama researchers will develop a nano-bio-sensors database that will be used over an upgraded connection between the HudsonAlpha Institute of Biotechnology, Alabama A&M University, Alabama State University, and the Alabama Research and Education Network (AREN) backbone. (eurekalert.org)
  • This RII C2 award will enable the University of Hawaii System, which comprises all public higher education instiutions in Hawaii including community colleges, to provide new inter-island connections among four specific locations that are most critical to Hawaii's research program in biodiversity, as well as to Hawaii's overall S&T and STEM education agendas. (eurekalert.org)
  • Subsidy funds are available on a rolling basis from the Nathan Shock Center for the Biology of Aging for subsidized use of U-M Research Resource Cores for problems in aging research. (constantcontact.com)
  • Classifying cancers in adolescents and young adults according to this new system will improve the international comparability of data collected by cancer registries and facilitate comparative epidemiological and clinical research. (who.int)
Institute4
  • Systems biology is not just about measuring as many things as possible," says lya Shmulevich, Ph.D., a professor at the Institute for Systems Biology. (genengnews.com)
  • The institute, to be called the Derrida Center for Postmodern Systems Biology, will be the first of its kind to be headed by a non-scientist. (genomeweb.com)
  • NPJ systems biology and applications / Systems Biology Institute. (bvs.br)
  • Data from the Surveillance, Epidemiology, and End Results (SEER) Program of the United States National Cancer Institute are used to illustrate the classification system. (who.int)
Insights2
  • Recent technological advances have provided insights into mechanistic details of auxin signaling and its many roles in plant biology. (cshlpress.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent insights into how auxin levels are regulated and, in turn, drive various developmental processes in plants. (cshlpress.com)
Integrative1
  • Herein, a promising computational systems biology method couples known perturbations on five biomolecules caused by the CP4 EPSPS GM of Glycine max L. (soybean), with an integrative model of C1 metabolism and oxidative stress (two molecular systems critical to plant function). (scirp.org)
Methodologies2
  • We do this by comparing the development, implementation, and characteristics of tools that have been developed to work with two divergent methodologies: Systems Biology and Pharmacometrics. (medworm.com)
  • Our goal is to obtain new biological knowledge with an in-silico approach which complements the in-vivo and in-vitro methodologies of Biology. (csic.es)
Dynamical2
  • The approach in this project relied strongly on novel dynamical systems methods for systems with multiple time scale dynamics, known as geometric singular perturbation theory (GSPT). (europa.eu)
  • New geometric techniques and dynamical systems methods for the analysis of medium sized models with complicated slow-fast dynamics have been developed which considerably extend the scope and applicability of GSPT. (europa.eu)
Clinical4
  • to support their translation to clinical use and gain insight into the fundamental biology behind them. (liverpool.ac.uk)
  • IMSEAR at SEARO: Bio-availability and drug delivery systems: clinical perspective. (who.int)
  • IMRT and SBRT Treatment Planning Study for the First Clinical Biology-Guided Radiotherapy System. (bvsalud.org)
  • The first clinical biology -guided radiation therapy (BgRT) system-RefleXionTM X1-was installed and commissioned for clinical use at our institution. (bvsalud.org)
Molecular systems3
  • Do GMOs Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria? (scirp.org)
  • The results predict significant accumulation of formaldehyde and concomitant depletion of glutathione in the GMO, suggesting how a "small" and single GM creates "large" and systemic perturbations to molecular systems equilibria. (scirp.org)
  • Ayyadurai, V.A.S. and Deonikar, P. (2015) Do GMOs Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria? (scirp.org)
Computational methods3
  • Regulatory agencies, currently reviewing rules for GMO safety, may wish to adopt a systems biology approach using a combination of in silico, computational methods used herein, and subsequent targeted experimental in vitro and in vivo designs, to develop a systems understanding of "equivalence" using biomarkers, such as formaldehyde and glutathione, which predict metabolic disruptions, towards modernizing the safety assessment of GMOs. (scirp.org)
  • depicts the current computational methods used to analyze different types of high-throughput as well as small scale in-depth experimental data in systems biology. (portlandpress.com)
  • Here, we present a brief overview of current experimental and computational methods used in systems biology. (portlandpress.com)
Emergent properties1
  • Systems biology, which aims to understand complexity of the whole organism, as a system, rather than just studying its parts in a reductionist manner, may provide a framework to determine appropriate criteria, as it recognizes that GM, small or large, may affect emergent properties of the whole system. (scirp.org)
Developmental1
  • This volume is therefore an essential reference for all plant biologists, as well as systems biologists, biochemists, and developmental biologists interested in the regulation of plant morphogenesis and behavior. (cshlpress.com)
Epidemiology1
  • The new classification system reflects the specific biology and epidemiology of cancers diagnosed in people aged 15-39 years. (who.int)
Nervous2
  • Specifically, we analyzed transcriptional and microRNA-based post-transcriptional regulation of these genes and performed functional enrichment analyses to understand their involvement in nervous system-related diseases and phenotypes. (nih.gov)
  • To further probe the impact of autophagy-lysosomal gene deficits on neurologically-linked phenotypes, we also mined the mouse knockout phenotype data for the autophagylysosomal genes and found them to be highly predictive of nervous system dysfunction. (nih.gov)
Modern biology2
  • Modeling is an integral component of modern biology. (medworm.com)
  • Although the undergraduate program provides students with flexibility in selecting the areas of biology most compatible with their interests and skills, it also ensures that students develop an overview of the major concepts and problems of modern biology as expressed at all levels of biological organization. (brocku.ca)
Study7
  • Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. (semanticscholar.org)
  • The application of systems biology to the study of cancer has been termed cancer systems biology. (medscape.com)
  • Although cancer systems biology has made pivotal contributions to the integral study of this disease, [ 5 ] the discipline is still in its infancy and it must deal with a number of important challenges in order to provide definitive solutions for a true personalized oncology. (medscape.com)
  • For the functional study of biological networks, we continued to improve our pioneering MBROLE system for the functional analysis of metabolomic data, with an exhaustive study of the role of intrinsic protein disorder in shaping molecular networks of Arabidopsis thaliana. (csic.es)
  • A new study suggests a nearby supernova caused a massive gas cloud to collapse - and form the solar system. (cosmosmagazine.com)
  • A total of 42 patient plans across 6 cancer sites (conventionally fractionated lung , head , and neck , anus , prostate , brain , and lung SBRT) planned with the EclipseTM treatment planning system (TPS) and treated with either a TrueBeam® or Trilogy® were selected for this retrospective study . (bvsalud.org)
  • a System Biology Study. (cdc.gov)
Sciences2
  • The developed data acquisition system and its component modules can be used for many applications in Life Sciences, Physics, and other fields. (suny.edu)
  • Architecture & Design, Biology/Life Sciences, Business/Management. (internationalscholarships.com)
Mechanisms4
  • At Weill Cornell Medical College, the laboratory of Olivier Elemento, Ph.D., combines computational biology and systems biology to identify mechanisms of drug resistance. (genengnews.com)
  • Dr. Elemento's team used a computational/systems biology strategy when it demonstrated that transcriptome sequencing could be used to identify mechanisms of drug action and resistance. (genengnews.com)
  • I'm referring to an article that its authors, Sun et al, entitled To Unveil the Molecular Mechanisms of Qi and Blood through Systems Biology-Based Investigation into Si-Jun-Zi-Tang and Si-Wu-Tang formulae . (scienceblogs.com)
  • Our goal will be to understand molecular mechanisms the brain employs to accomplish learning and memory.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. (merlot.org)
20161
Perturbations1
  • [ 3 ] Once systems are generated, their behavior can be studied in the presence of different external or internal stimuli or perturbations and, more importantly, the outcome for each of these cues can be anticipated. (medscape.com)
University2
  • The ICES 2010 conference is organised by the Intelligent Systems Group in the Department of Electronics of the University of York. (wikicfp.com)
  • Dr. Dugan earned a Bachelor of Science degree in biology from Union College, a Master of Science in veterinary parasitology, and a Doctor of Philosophy in infectious diseases from the College of Veterinary Medicine, University of Georgia, where she specialized in zoonotic, tick-borne pathogens. (cdc.gov)
Iron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus |...
Iron competition triggers antibiotic biosynthesis in Streptomyces coelicolor during coculture with Myxococcus xanthus |... (systemsbiology.ucsd.edu)
Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis | Systems...
Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis | Systems... (systemsbiology.ucsd.edu)
Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli. |...
Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli. |... (systemsbiology.ucsd.edu)
Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces...
Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces... (systemsbiology.ucsd.edu)
The COVID vaccine makers tell all
The COVID vaccine makers tell all (nature.com)
The selective pressures on the microbial community in a metal-contaminated aquifer | The ISME Journal
The selective pressures on the microbial community in a metal-contaminated aquifer | The ISME Journal (nature.com)
Biomedical Engineering Society | Cambridge University Press
Biomedical Engineering Society | Cambridge University Press (cambridge.org)
4th European Conference of Computational Biology | Cambridge University Press
4th European Conference of Computational Biology | Cambridge University Press (cambridge.org)
An Introduction to Systems Biology - Studydrive
An Introduction to Systems Biology - Studydrive (studydrive.net)
John Abel | Systems, Synthetic, and Quantitative Biology
John Abel | Systems, Synthetic, and Quantitative Biology (ssqbiophd.hms.harvard.edu)
Noriko Nakamura | FDA
Noriko Nakamura | FDA (fda.gov)
Cdna definition - AntibodyX - Systems Biology of Humoral Immunity
Cdna definition - AntibodyX - Systems Biology of Humoral Immunity (antibodyx.org)
Role of Data Aggregation in Biosurveillance Detection Strategies with Applications from ESSENCE
Role of Data Aggregation in Biosurveillance Detection Strategies with Applications from ESSENCE (cdc.gov)
Schools and Departments, La Trobe University
Schools and Departments, La Trobe University (latrobe.edu.au)
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis | Nature
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis | Nature (nature.com)
PDF] Complex systems biology | Semantic Scholar
PDF] Complex systems biology | Semantic Scholar (semanticscholar.org)
Biology | Argonne National Laboratory
Biology | Argonne National Laboratory (anl.gov)
Evolution Drives The Diversity And Unity Of Life - 1674 Words | Bartleby
Evolution Drives The Diversity And Unity Of Life - 1674 Words | Bartleby (bartleby.com)
Erik Wright, Ph.D. | Integrative Systems Biology | University of Pittsburgh
Erik Wright, Ph.D. | Integrative Systems Biology | University of Pittsburgh (pimb.pitt.edu)
Missoula, Montana - Wikipedia
Missoula, Montana - Wikipedia (en.wikipedia.org)
Stefan Streif - Understanding Phototaxis of Halobacterium salinarum
Stefan Streif - Understanding Phototaxis of Halobacterium salinarum (shaker.de)
Systems and synthetic biology - SINTEF
Systems and synthetic biology - SINTEF (sintef.no)
Phylogeny - SIB Swiss Institute of Bioinformatics | Expasy
Phylogeny - SIB Swiss Institute of Bioinformatics | Expasy (expasy.org)
Halobacterium phototaxis | Max Planck Institute of Biochemistry
Halobacterium phototaxis | Max Planck Institute of Biochemistry (biochem.mpg.de)
CDH1 ELISA Kits | Biocompare
CDH1 ELISA Kits | Biocompare (biocompare.com)
Magazine Issue - May 2010 | May 2010 | Drug Discovery News
Magazine Issue - May 2010 | May 2010 | Drug Discovery News (drugdiscoverynews.com)