A comparison of techniques for the quantitative analysis of hyaluronic acid in equine synovial fluid. (1/1952)
A comparison of methods of preparing the hyaluronic acid of equine synovial fluid for quantitative spectrophotographic analysis is presented. A new method is proposed which appears superior to the previous methods. (+info)Serum response elements activate and cAMP responsive elements inhibit expression of transcription factor Egr-1 in synovial fibroblasts of rheumatoid arthritis patients. (2/1952)
Analyzing the induction kinetics and promoter elements regulating the expression of the transcription factor Egr-1, we found elevated levels of Egr-1-encoding mRNA in synovial fibroblasts of rheumatoid arthritis (RA) patients when compared to controls. By contrast, synovial lymphocytes and macrophages do not show an elevated Egr-1 transcription. Therefore, the overexpression of Egr-1 may serve as a diagnostic marker to characterize synovial fibroblasts of RA patients. To study the regulatory mechanisms controlling Egr-1 expression we analyzed the function of transcription factor binding sites located in the Egr-1 promoter. Individual transcription factor binding sites within the Egr-1 promoter were specifically mutated and Egr-1 promoter activity was tested using reporter gene constructs. Our experiments demonstrate that serum response elements are the main positive regulators and binding to a cAMP responsive element represents the major negative regulator for Egr-1 expression in synovial fibroblasts. In addition, we functionally defined a new element, which was not yet described in the human Egr-1 promoter and which serves as a second negative regulatory element for Egr-1 expression. Therefore increased serum response factor activity or failure of Egr-1 repressing signals may account for Egr-1 overexpression in RA synovial fibroblasts. (+info)Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2. (3/1952)
1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A2 (PLA2), showing selectivity for secretory PLA2 (sPLA2) versus cytosolic PLA2 (cPLA2), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2. This activity was confirmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA2 present in paw homogenates of rats with adjuvant arthritis. 3. This marine metabolite showed topical anti-inflammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg(-1). 4. In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor alpha (TNFalpha) in the exudates 4 h after the stimulus. It also had a weak effect on cell migration. 5. The inflammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not significantly affect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic effects. 6 Cacospongionolide B is a new inhibitor of sPLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation. This marine metabolite was active after oral administration and able to modify TNFalpha levels, and may offer an interesting approach in the search for new anti-inflammatory agents. (+info)Cytokine levels in synovial fluid from hips with well-functioning or loose prostheses. (4/1952)
We analysed synovial fluid from 88 hips, 38 with osteoarthritis and 12 with well-functioning and 38 with loose hip prostheses. The levels of TNF-alpha, IL-1beta (71 hips) and IL-6 (45 hips) were measured using the ELISA technique. Joints with well-functioning or loose prostheses had significantly increased levels of TNF-alpha compared with those with osteoarthritis. Hips with aseptic loosening also had higher levels of IL-1beta but not of IL-6 compared with those without an implant. The levels of TNF-alpha and IL-1beta did not differ between hips with stable and loose prostheses. Higher levels of TNF-alpha were found in hips with bone resorption of type II and type III (Gustilo-Pasternak) compared with those with type-I loosening. The level of cytokines in joint fluid was not influenced by the time in situ of the implants or the age, gender or area of the osteolysis as measured on conventional radiographs. Our findings support the theory that macrophages in the joint capsule increase the production of TNF-alpha at an early phase probably because of particle load and in the absence of clinical loosening. Since TNF-alpha has an important role in the osteolytic process, the interfaces should be protected from penetration of joint fluid. (+info)Synovial fluid transforming growth factor beta inhibits dendritic cell-T lymphocyte interactions in patients with chronic arthritis. (5/1952)
OBJECTIVE: To examine whether rheumatoid synovial fluid (SF) inhibits dendritic cell (DC) expression of the CD80 and CD86 costimulator molecules and contributes to SF T lymphocyte hyporesponsiveness. METHODS: Cell-free rheumatoid SF was tested for its effect on DC-stimulated autologous/allogeneic mixed lymphocyte reactions and for its effect on DC surface antigen expression, as assessed by flow cytometry. Blocking monoclonal antibodies were used to identify the SF cytokines that inhibited DC-T lymphocyte interactions. RESULTS: Low concentrations of SF (2.5%) could inhibit DC-mediated autologous and allogeneic T lymphocyte proliferation. This inhibitory effect could be reversed by neutralizing transforming growth factor beta (TGFbeta) and interleukin-2 (IL-2), but not by IL-12, in the SF. Hyaluronic acid, IL-6, IL-10, and tumor necrosis factor alpha were not associated with SF inhibition. In vitro culture alone and crosslinking with the CD40 ligand up-regulated DC CD80/CD86 expression and costimulator function, and this was not affected by inclusion of SF. In the presence of SF, DC clustered with autologous T lymphocytes showed decreased CD80 and CD86 expression, and variable CD80/CD86 decreases were observed on DC clustered with allogeneic T lymphocytes. CONCLUSIONS: TGFbeta in SF appears to suppress T lymphocyte function, which may affect both signaling to DC and the induction of DC costimulator function. (+info)Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. (6/1952)
OBJECTIVE: To determine the concentrations of aggrecan fragments in synovial fluid from patients with knee joint injury, osteoarthritis (OA), or acute pyrophosphate arthritis (PPA; pseudogout), and to test their relative reactivity with the 846 epitope, a putative marker of cartilage aggrecan synthesis. METHODS: Samples of knee joint fluid from 385 patients and 9 healthy-knee volunteers were obtained in a cross-sectional study. Study groups were acute PPA/ pseudogout (n = 60), anterior cruciate ligament (ACL) rupture (n = 159), meniscus lesion (n = 129), and primary knee OA (n = 37). The 846 epitope on aggrecan was assayed by competitive solution-phase radioimmunoassay. Aggrecan fragments were assayed by enzyme-linked immunosorbent assay using a monoclonal antibody (1-F21). Cartilage oligomeric matrix protein (COMP), C-propeptide of type II collagen (CPII), bone sialoprotein, matrix metalloproteinases 1 and 3, and tissue inhibitor of metalloproteinases 1 were previously quantified by immunoassays. RESULTS: Reactivity of the 846 epitope was increased in all study groups compared with the reference group, and was highest in patients with primary OA. The median levels (in microg fetal aggrecan equivalents/ml) of the epitope were 0.28 (range 0.24-0.47) in the reference group, 0.48 (range 0.26-1.32) in PPA/pseudogout, 0.61 (range 0.12-2.87) in ACL rupture, 0.53 (range 0.22-3.02) in meniscus lesion, and 0.68 (range 0.31-4.31) in primary OA. The 846 epitope reactivity per microg aggrecan fragments in the joint fluid was higher in late-stage OA than in early-stage OA. Epitope 846 reactivity correlated positively with several markers of matrix turnover, particularly with COMP (r(s) = 0.421) and CPII (r(s) = 0.307). CONCLUSION: The observed differences in 846 epitope reactivity in synovial fluid, and its concentration in relation to aggrecan and other markers of matrix turnover, were consistent with marked ongoing changes in aggrecan turnover after joint injury and in the development of OA. OA is thus a disease characterized by dynamic changes in tissue macromolecule turnover, which is reflected by measurable changes in aggrecan epitopes in the synovial fluid. (+info)Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. (7/1952)
OBJECTIVE: To determine if diacerhein protects against the early stages of joint damage in a canine model of osteoarthritis (OA). METHODS: OA was induced in 20 adult mongrel dogs by transection of the anterior cruciate ligament of the left knee. Beginning the day after surgery, dogs in the active treatment group were dosed twice a day with capsules of diacerhein, providing a total daily dose of 40 mg/kg, for 32 weeks. Dogs in the control group received placebo capsules on the same schedule. Pathology in the unstable knee was assessed arthroscopically 16 weeks after surgery and by direct observation when the dogs were killed 32 weeks after surgery. The severity of gross joint pathology was recorded, and samples of the medial femoral condyle cartilage and the synovial tissue adjacent to the central portion of the medial meniscus were collected for histologic evaluation. Water content and uronic acid concentration of the articular cartilage from the femoral condyle were determined, and collagenolytic activity in extracts of cartilage pooled from the medial and lateral tibial plateaus was assayed against 14C-labeled collagen fibers. RESULTS: Diacerhein treatment slowed the progression of OA, as measured by grading of gross changes in the unstable knee at arthroscopy 16 weeks after cruciate ligament transection (P = 0.04) and at the time the animals were killed, 32 weeks after surgery (P = 0.05). However, 32 weeks after ACL transection, the mean proteoglycan concentration and water content of the OA cartilage and the level of collagenolytic activity in extracts of the cartilage were not significantly different in the diacerhein treatment group than in the placebo treatment group. CONCLUSION: Diacerhein treatment significantly reduced the severity of morphologic changes of OA compared with placebo. These findings support the view that diacerhein may be a disease-modifying drug for OA. (+info)Infected total hip arthroplasty--the value of intraoperative histology. (8/1952)
Intraoperative histology showed a sensitivity of 100% and a specificity of 98%. These results were better than those observed for the other tests evaluated. Our data provide evidence that intraoperative histology is useful tool in the diagnosis of infected total hip arthroplasty. (+info)
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Synovial fluid
The fluid in articular cartilage effectively serves as a synovial fluid reserve. During movement, the synovial fluid held in ... Synovial fluid is a small component of the transcellular fluid component of extracellular fluid. The inner membrane of synovial ... Synovial fluid, also called synovia,[help 1] is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With ... Synovial fluid may be collected by syringe in a procedure termed arthrocentesis, also known as joint aspiration. Synovial fluid ...
Arthrocentesis
... or unknown cause of joint effusion should undergo arthrocentesis with synovial fluid analysis. Samples of synovial fluid can be ... Yellow-green appearing synovial fluid may indicate the presence of inflammation or infection. In the case of an infection or ... Normal synovial fluid should not have any cells or crystals present and should appear colorless and clear.[citation needed] ... Aspiration of synovial fluid in cases of joint effusion or hemarthrosis can help reduce pressure around the joints, thus ...
Synovial joint
The synovial cavity/joint is filled with synovial fluid. The joint capsule is made up of an outer layer of fibrous membrane, ... Synovial cavity: all diarthroses have the characteristic space between the bones that is filled with synovial fluid Joint ... the inner synovial membrane that secretes the lubricating, shock absorbing, and joint-nourishing synovial fluid; the joint ... that are filled with fluid that is similar to synovial fluid[page needed] The bone surrounding the joint on the proximal side ...
Chondronectin
Carsons, S; Horn, VJ (1988). "Chondronectin in human synovial fluid". Annals of the Rheumatic Diseases. 47 (10): 797-800. doi: ...
Calcium pyrophosphate dihydrate crystal deposition disease
Arthrocentesis, or removing synovial fluid from the affected joint, is performed to test the synovial fluid for the calcium ... Dieppe, P.; Swan, A. (1 May 1999). "Identification of crystals in synovial fluid". Annals of the Rheumatic Diseases. 58 (5): ... The crystals are usually detected by imaging and/or joint fluid analysis.[citation needed] Medical imaging, consisting of x-ray ... "Calcium Pyrophosphate Dihydrate Deposition Disease: Synovial Biopsy, Wrist". Rheumatology Image Bank. American College of ...
Septic arthritis
It cannot be cultured from synovial fluid. However, PCR testing yields 85% positive result from synovial fluid. Viruses such as ... Synovial fluid cultures are positive in 25 to 70% of the cases while blood cultures are seldom positive. Apart from blood and ... However, septic synovial fluid can have white blood cell counts as low as a few thousand in the early stages. Therefore, ... Synovial fluid cultures will be positive in 80% of the cases. However, acid fast smears are not useful. Histology is not ...
Rheopecty
Examples of rheopectic fluids include gypsum pastes and printer inks. In the body synovial fluid exhibits the extraordinary ... O'Neill, p.l (1996). "The Inverse Thixotropic Behaviour of Synovial Fluid". Journal of Orthopaedic Rheumatology. 9 (4): 222-228 ... the longer the fluid undergoes shearing force, the higher its viscosity. Rheopectic fluids, such as some lubricants, thicken or ... These terms are often and easily confused since the terms are rarely used; a true rheopectic fluid would when shaken be liquid ...
Injection (medicine)
Hyaluronic acid injection is used to supplement the body's natural synovial fluid and decrease the friction and stiffness of ... "Joint aspiration and injection and synovial fluid analysis". Best Practice & Research Clinical Rheumatology. 27 (2): 137-169. ... can range from a one-time dose of a steroid to help with pain and inflammation to complete replacement of the synovial fluid ...
Beta-mannosidase
Bartholomew, B.A. & Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta. 315 ...
Aggrecan
Sandy JD, Flannery CR, Neame PJ, Lohmander LS (1992). "The structure of aggrecan fragments in human synovial fluid. Evidence ...
Ganglion cyst
The fluid is similar in composition to synovial fluid. Dye injected into the joint capsule frequently ends up in the cyst, ... A ganglion cyst is a fluid-filled bump associated with a joint or tendon sheath. It most often occurs at the back of the wrist ... Alternatively, a hypodermic needle may be used to drain the fluid from the cyst (via aspiration) and a corticosteroid may be ... The underlying mechanism is believed to involve an outpouching of the synovial membrane. Risk factors include gymnastics ...
Joint cracking
... some of the gases that are dissolved in the synovial fluid (which are naturally found in all bodily fluids) leave the solution ... Synovial fluid cavitation has some evidence to support it. When a spinal manipulation is performed, the applied force separates ... Suggested causes included: Cavitation within the joint-small cavities of partial vacuum form in the synovial fluid and then ... while the gases are slowly reabsorbed into the synovial fluid. There is some evidence that ligament laxity may be associated ...
Hemarthrosis
Synovial Fluid analysis is another method to diagnose Hemarthrosis. It involves a small needle being inserted into the joint to ... Seidman, Aaron J.; Limaiem, Faten (2019), "Synovial Fluid Analysis", StatPearls, StatPearls Publishing, PMID 30725799, ... draw the fluid. Reddish-colored hue of the sample is an indication of the blood being present. Imaging tests are normally done ...
Synovitis
The joint usually swells due to synovial fluid collection. Synovitis may occur in association with arthritis as well as lupus, ... Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that possess cavities, ... In rheumatoid arthritis, the fibroblast-like synoviocytes, highly specialized mesenchymal cells found in the synovial membrane ... Nygaard, Gyrid; Firestein, Gary S. (2020). "Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like ...
Robert Tuttle Morris
Morris had invented a sort of artificial synovial fluid. Made out by a mixture of boroglyceride, glycerine and normal saline ... And he actually found out that pepsin acted best and was able to turned blood clot into semi-fluid form. Moreover, pepsin was ... The consequences of all of its specific characteristics were that when injected into a joint, this fluid resisted absorption ... solution, it resulted to be antiseptic and hygroscopic, so that it had a tendency to draw serous fluids towards itself. ...
Synovial membrane
The synovial fluid can be thought of as a specialised fluid form of synovial extracellular matrix rather than a secretion in ... In contact with the synovial fluid at the tissue surface are many rounded macrophage-like synovial cells (type A) and also type ... As for the FLS, they produce hyaluronan, as well as other extracellular components in the synovial fluid. The synovial membrane ... It makes direct contact with the fibrous membrane on the outside surface and with the synovial fluid lubricant on the inside ...
Gonorrhea
Synovial fluid should be collected in cases of septic arthritis. All people testing positive for gonorrhea should be tested for ... It may be able to spread through the objects contaminated with body fluid from an infected person. The bacteria typically does ...
Knee bursae
The bursae are thin-walled, and filled with synovial fluid. They represent the weak point of the joint, but also provide ... The knee bursae are the fluid-filled sacs and synovial pockets that surround and sometimes communicate with the knee joint ... ISBN 3-13-533305-1. Image at nlm.nih.gov (Articles using infobox templates with no data rows, Synovial bursae, Lower limb ...
Osteochondritis dissecans
Stages III and IV describe unstable lesions in which a lesion of the cartilage has allowed synovial fluid between the fragment ... Rodrigo JJ, Steadman JR, Syftestad G, Benton H, Silliman J (1995). "Effects of human knee synovial fluid on chondrogenesis in ... This examination may reveal fluid in the joint, tenderness, and crepitus. The Wilson test is also useful in locating OCD ... Physical examination typically reveals fluid in the joint, tenderness, and crepitus. The tenderness may initially spread, but ...
PLA2G2A
"Entrez Gene: PLA2G2A Phospholipase A2, group IIA (platelets, synovial fluid)". Kramer RM, Johansen B, Hession C, Pepinsky RB ( ... Lai CY, Wada K (1989). "Phospholipase A2 from human synovial fluid: purification and structural homology to the placental ... 1989). "Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid". J. Biol. Chem. ... 1991). "Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution". Nature. 352 ( ...
Major histocompatibility complex, class I-related
There was also higher production of IL-17 by MAIT cells in peripheral blood and even higher in synovial fluid (none of these ... On the contrary, it was highly elevated in synovial fluid. Also some phenotypical changes have been shown. For example, ...
Proteoglycan 4
... of lubricin makes it a water-soluble synovial fluid protein. In synovial fluid it interacts with Galectin-3 that improves its ... Furthermore, the synovial fluid of patients with rheumatoid arthritis and osteoarthritis has been shown to exhibit reduced ... Early work on lubricin showed that it was able to lubricate non cartilaginous surfaces as effectively as whole synovial fluid, ... Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an ...
Gout
All synovial fluid samples obtained from undiagnosed inflamed joints by arthrocentesis should be examined for these crystals. ... A definitive diagnosis of gout is based upon the identification of monosodium urate crystals in synovial fluid or a tophus. ... To help with diagnosis, a synovial fluid Gram stain and culture may be performed. Other conditions that can look similar ... Seidman, Aaron J.; Limaiem, Faten (2019), "Synovial Fluid Analysis", StatPearls, StatPearls Publishing, PMID 30725799, ...
Alicia Bertone
Bertone, A. L.; Palmer, J. L.; Jones, J. (December 2001). "Synovial fluid cytokines and eicosanoids as markers of joint disease ... Bertone, A. L.; Palmer, J. L.; Jones, J. (December 2001). "Synovial fluid cytokines and eicosanoids as markers of joint disease ... She conducted study to evaluate various synovial fluid cytokines and eicosanoids for the diagnosis of joint disease and ...
Limb perfusion
"Meropenem synovial fluid concentrations after intravenous regional limb perfusion in standing horses". Veterinary Surgery. 47 ( ... Management of wounds involving synovial structures in horses. Clinical Techniques in Equine Practice. Vol 3(2): 204-214. ... infection of a synovial structure (joint, tendon sheath, bursa), or osteomyelitis. RLP has been shown to produce antibiotic ...
Gram stain
... examples are cerebrospinal fluid for meningitis and synovial fluid for septic arthritis. Gram-positive bacteria have a thick ... Gram stains are performed on body fluid or biopsy when infection is suspected. Gram stains yield results much more quickly than ...
Interleukin 20
IL-20 is highly expressed in the synovial fluid of RA patients. Serum levels of IL-20 are not different from those of healthy ... Receptors for IL-20 are highly expressed in the synovial membranes of RA patients. Due to the clear association of IL-20 with ... IL-20 stimulates the secretion of chemokines MCP-1 and IL-8 in synovial fibroblasts, which attract neutrophils and T-cells. IL- ...
Synovial osteochondromatosis
Cartilaginous intra-articular bodies float freely within the synovial fluid, which they require for nutrition and growth. ... Synovial osteochondromatosis (SOC) (synonyms include synovial chondromatosis, primary synovial chondromatosis, synovial ... Also, they can deposit in the synovial lining, reestablish a blood supply, and become replaced by bone. On occasion, synovial ... Degenerative joint disease with detached spur Synovial proliferation: Pigmented villonodular synovitis Neoplastic: Synovial ...
Leptin
As in the plasma, the leptin levels in the synovial fluid are positively correlated with BMI. The leptin of the synovial fluid ... For example, leptin can be found in the synovial fluid in correlation with the body mass index, and the leptin receptors are ... July 2006). "Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. ... Leptin has been shown to be produced by chondrocytes, as well as by other tissues in the joints, including the synovial tissue ...
Bursitis
... of synovial fluid in the body. They are lined with a synovial membrane that secretes a lubricating synovial fluid. There are ... Bursitis is the inflammation of one or more bursae (fluid filled sacs) ...
Mycoplasma incognitus
1998) Genotypic Characterization of Seven Strains of Mycoplasma fermentans Isolated From Synovial Fluids of Patients With ... This mycoplasma is highly contagious, and can be passed from person to person via bodily fluids, such as sweat and blood. Since ...
Equine anatomy
As tendons pass near bony prominences, they are protected by a fluid filled synovial structure, either a tendon sheath or a sac ... which contribute fluid to the semen at ejaculation, but are not strictly necessary for fertility. A horse's teeth include ...
Yin Yoga
... joints and synovial fluid". Los Angeles Times. Pizer, Ann (17 May 2012). "Yin Yoga". about.com Yoga. Retrieved 11 January 2013 ...
Fibroblast-like synoviocyte
The word "synovium" is derived from the word "synovia" (or synovial fluid), which is a clear, viscous fluid produced by the ... These cells represent the main source of hyaluronic acid and also other glycoproteins, major components of the synovial fluid. ... Synovial membrane is divided into two compartments - the outer layer (subintima) and the inner layer (intima). The inner layer ... Synovial hyperplasia (an increase in cell number) is a typical feature of the autoimmune disease called rheumatoid arthritis ( ...
Zymoblot
The detection of an enzyme not known to be normally present in a sample of body fluid (e.g. blood serum, CSF, synovial fluid, ... Similarly, replacing biological fluids with non-biological fluids taken from water bodies (or prepared from similar ...
Prepatellar bursitis
... or particles within the excess synovial fluid.: p. 20 In human anatomy, a bursa is a small pouch filled with synovial fluid. ... aspiration of the bursal fluid is often required for this, along with a cell culture and Gram stain of the aspirated fluid.: p ... The trauma can cause extravasation of nearby fluids into the bursa, which stimulates an inflammatory response. This response ... Severe cases may require fine-needle aspiration of the bursa fluid, sometimes coupled with cortisone injections. However, some ...
Posterior cruciate ligament
They are both isolated from the fluid-filled synovial cavity, with the synovial membrane wrapped around them. The PCL gets its ...
Lyme disease
... because it is a highly sensitive way of detecting ospA DNA in synovial fluid. Although sensitivity of PCR in CSF is low, its ... "Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis". The ... continue to have joint swelling two months after treatment and have negative PCR test for Borrelia DNA in the synovial fluid ... Lymphocytic meningitis causes characteristic changes in the cerebrospinal fluid (CSF) and may be accompanied for several weeks ...
Anatomical terminology
Joints, especially synovial joints allow the body a tremendous range of movements. Each movement at a synovial joint results ... The serous membranes have two layers; parietal and visceral, surrounding a fluid filled space. The visceral layer of the ... Additionally, synovial joints can be divided into different types, depending on their axis of movement. A serous membrane (also ... The type of movement that can be produced at a synovial joint is determined by its structural type. Movement types are ...
Alpha-1 antitrypsin
... have been found to make autoantibodies toward the carbamylated form of A1AT in the synovial fluid. This suggests that A1AT may ...
Chondroitin sulfate
... absorbed in the gastro-intestinal tract and a high content of labeled chondroitin sulfate is found in the synovial fluid and ...
Subacromial bursitis
At US, an abnormal bursa may show fluid distension, synovial proliferation, and/or thickening of the bursal walls. In any case ... The inflammatory process causes synovial cells to multiply, increasing collagen formation and fluid production within the bursa ... MRI imagining can reveal fluid accumulation in the bursa and assess adjacent structures. In chronic cases caused by impingement ...
Vinculum (ligament)
The tendon receives some additional nutrition directly from the synovial fluid in the sheath, which is important in case of ... These vincula are four folds in the synovial membrane that carry blood vessels to the body and insertion of the tendon. ...
Biofluid dynamics
Air can also be considered as biological fluid as it flows in lungs and the synovial fluid between the knee joints is also an ... They are: Ideal Fluid Real Fluid Newtonian Fluid Non-Newtonian fluid An Ideal Fluid is a fluid that has no viscosity, means it ... A Newtonian Fluid is a fluid whose viscous shear stresses (acting between different layers of fluid and between the fluid layer ... Real fluids are compressible in nature. They offer some resistance and thus have viscosity. All Fluids existing are real fluids ...
ALOX15
... joint Synovial membrane cells, seminal fluid, prostate epithelium cells, and mammary ductal epithelial cells. The distribution ...
RVSV-ZEBOV vaccine
... and the vaccine was found replicating in the synovial fluid of the joints of the affected people; the clinical trial was halted ...
Joint manipulation
... some of the gases that are dissolved in the synovial fluid (which are naturally found in all bodily fluids) leave solution ... This sound is believed to be the result of a phenomenon known as cavitation occurring within the synovial fluid of the joint. ... created by synovial fluid resistance; conveniently within the limits of anatomical integrity provided by restraining tissues ... while it is slowly reabsorbed back into the synovial fluid. There is some evidence that ligament laxity around the target joint ...
Collagen hybridizing peptide
... or synovial fluid. Using conventional methods for directly targeting collagen, researchers have to relied on collagen binding ...
Ultrasound-guided hip joint injection
The hip joint is a ball-and-socket synovial joint, formed by an articulation between the femur and acetabulum. Intra-articular ... Successful targeting of the joint space is supported by spread of anechoic fluid beneath the iliofemoral fascia inside the ...
Bursectomy
A bursectomy is the removal of a bursa, which is a small sac filled with synovial fluid that cushions adjacent bone structures ... v t e (Orthopedic surgical procedures, Synovial bursae, All stub articles, Medical treatment stubs). ...
Anatomical terms of motion
Anterograde and retrograde flow refer to movement of blood or other fluids in a normal (anterograde) or abnormal (retrograde) ... Angular motions occur over synovial joints and causes them to either increase or decrease angles between bones. Rotational ...
Ossicles
Incudomalleolar joint - Synovial joint between malleus and incus Incudostapedial joint - Small joint between the incus and the ... They serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea). The absence of the auditory ossicles would ... The increased pressure will compress the fluid found in the cochlea and transmit the stimulus. Thus, the lever action of the ...
Index of anatomy articles
... sympathetic nervous system sympathetic trunk symphysis synapse synaptic bouton syncytium syndesmosis synovial fluid synovial ... tract cerebellum cerebral aqueduct cerebral arterial circle cerebral hemisphere cerebral peduncle cerebrospinal fluid cerebrum ...
Anterior cruciate ligament
... as it receives most of its nutrients from synovial fluid; this washes away the reparative cells, making the formation of ...
Synovial sac
The synovial sac is a thin tissue that lines the joint. It is filled with a fluid that works like oil in a car, lubricating the ... The synovial sac is one of the seven parts of a joint located in the body, along with muscle, tendon, ligament, bone, articular ...
Calcific bursitis
A bursa is a small, fluid-filled sac that reduces friction, and facilitates movements between its adjacent tissues (i.e., ... Synovial bursae). ...
Synovial fluid: MedlinePlus Medical Encyclopedia Image
Gout and Pseudogout Workup: Approach Considerations, Synovial Fluid Analysis, Serum Uric Acid
Synovial fluid should also be sent for cell count. During acute attacks, the synovial fluid is inflammatory, with a WBC count ... Analysis of synovial fluid for crystals should ideally be done within 24-48 hours after collection. Synovial fluid specimens ... Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. ... Minute quantities of fluid in the shaft or hub of the needle are sufficient for synovial fluid analysis. ...
Gout and Pseudogout Workup: Approach Considerations, Synovial Fluid Analysis, Serum Uric Acid
Synovial fluid should also be sent for cell count. During acute attacks, the synovial fluid is inflammatory, with a WBC count ... Analysis of synovial fluid for crystals should ideally be done within 24-48 hours after collection. Synovial fluid specimens ... Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. ... Minute quantities of fluid in the shaft or hub of the needle are sufficient for synovial fluid analysis. ...
JCI -
Usage information: Carbohydrate heterogeneity of fibronectins. Synovial fluid fibronectin resembles the form secreted by...
Large quantities of fibronectin (Fn) are present in inflammatory synovial fluid. Inflammatory synovial fluid Fn, while ... synovial fluid Fn contains N-acetyl galactosamine indicating the presence of O-linked oligosaccharides. Synovial fluid Fn and ... Synovial fluid Fn has a greater carbohydrate content but contains less sialic acid when compared with plasma Fn. Glycopeptides ... Synovial fluid fibronectin resembles the form secreted by cultured synoviocytes but differs from the plasma form.. ...
Bone, cartilage and synovial fluid: an integrated approach to joint health
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes |...
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ... Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ... Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ...
synovial fluid - definition of synovial fluid - synonyms, pronunciation, spelling from Free Dictionary
... fluid. What does synovial_fluid mean? Meaning of synovial_fluid. synovial_fluid synonyms, pronunciation, spelling and more from ... 1. viscid lubricating fluid secreted by the membrane lining joints and tendon sheaths etc.; [syn: synovia, synovial fluid]. The ... synovial fluid n 1: viscid lubricating fluid secreted by the membrane lining joints and tendon sheaths etc. [syn: synovia, ... Synovial fluid, synovia. Synovial membrane, the dense and very smooth connective tissue membrane which secretes synovia and ...
The concordance between preoperative aspiration and intraoperative synovial fluid culture results: intraoperative synovial...
2) compared to intraoperative synovial fluid cultures, the sensitivity of preoperative aspiration fluid culture. Then the ... The intraoperative synovial fluid re-cultures are necessary if the preoperative aspiration culture is positive and the ... Compared to intraoperative synovial fluid culture, the sensitivity, specificity, positive predictive value (PPV), and negative ... But the discordance between preoperative aspiration culture and intraoperative synovial fluid culture remains unknown. We aim ...
Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest recently when markers more...
Synovial fluid analysis Sensitivity, specificity, and positive and negative predictive ideals of synovial SB366791 alpha ... Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest recently when markers more ... Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest recently when markers more ... Genomics Proteomics and Bioinformatics , Thromboxane Receptors , Synovial fluid analysis for diagnosis of prosthetic joint ...
Optical Fiber Infrared Spectroscopy Identifies Septic vs Nonseptic Synovial Fluids - Rheumatology Advisor
Researchers sought to confirm the interest of mid-infrared spectroscopy to discriminate synovial fluid samples from patients ... used 16S polymerase chain reaction analysis and a synovial fluid bacteriologic analysis and culture to classify synovial fluid ... Investigators obtained synovial fluids from each patient and used a chalcogenide fiber sensor to acquire the infrared ... Optical Fiber Infrared Spectroscopy Identifies Septic vs Nonseptic Synovial Fluids. Brandon May ...
Uric Acid (Synovial Fluid)
Synovial Fluid Analysis - Accuteqs
Synovial Fluid Archives - Arbor Assays
Synovial fluid (dog, cat) | eClinpath
Gout and Pseudogout Workup: Approach Considerations, Synovial Fluid Analysis, Serum Uric Acid
Synovial fluid should also be sent for cell count. During acute attacks, the synovial fluid is inflammatory, with a WBC count ... Analysis of synovial fluid for crystals should ideally be done within 24-48 hours after collection. Synovial fluid specimens ... Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. ... Minute quantities of fluid in the shaft or hub of the needle are sufficient for synovial fluid analysis. ...
Cell growth characteristics of equine synovial fluid stem cells
Besides these synovial fluid and synovial membrane represents a promising source of mesenchymal stem cells, which can be ... Our study demonstrated the characteristics of equine synovial fluid derived stem cells, an ideal candidate for veterinary ... The aim of our study was to evaluate the growth characteristics of equine synovial liquid stem cells harvested from the ...
Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020 | MMWR
... detected by rRT-PCR in the synovial fluid of four of seven vaccinated participants with joint complaints whose synovial fluid ... One synovial fluid specimen tested positive by rRT-PCR 15 dpv and virus isolation was negative (Source: Agnandji ST, Huttner A ... With the detection of vaccine virus in synovial fluid (56,58,59) in a proportion of vaccinated persons with joint complaints, ... Of three participants in one study, whose synovial fluid was tested by rRT-PCR, one tested positive 17 dpv and two tested ...
IMSEAR at SEARO: Estimation & significance of serum & synovial fluid malondialdehyde levels in rheumatoid arthritis.
Serum and synovial fluid (SF) levels of malondialdehyde (MDA), a marker of free radical induced lipid peroxidation, were ... Estimation & significance of serum & synovial fluid malondialdehyde levels in rheumatoid arthritis.. Authors: Chaturvedi, V. ... Estimation & significance of serum & synovial fluid malondialdehyde levels in rheumatoid arthritis. Indian Journal of Medical ... and correlated with synovial fluid (SF) MDA levels. No difference was observed in SF-MDA levels in RA (0.17 +/- 0.07 nmol/ml) ...
IMSEAR at SEARO: Synovial fluid changes in mycoplasma induced septicaemic polyarthritis of goat kids.
Synovial fluid samples of goat kids inoculated (ip) with 5 ml of 48 hr log phase culture of Mycoplasma mycoides sub sp. ... Synovial fluid changes in mycoplasma induced septicaemic polyarthritis of goat kids. Indian Journal of Experimental Biology. ... Synovial fluid sugar contents were significantly reduced, whereas total protein contents were significantly increased with ... The alkaline phosphatase and transaminase values were also markedly increased in the synovial fluids of mycoplasma induced ...
Test for Synovial Fluid Near Me | Test Cost Delhi | GDIC
Book Test for Synovial Fluid at best price in Delhi NCR, India from GDIC. NABL Accredited. Fast and accurate result. Book now! ... Test for Synovial Fluid. Book Synovial Fluid Test at the best price in Delhi NCR, India from GDIC (Ganesh Diagnostic & Imaging ... What is the Synovial Fluid Test?. Synovial fluid is the lubricant that keeps your joints flowing smoothly. It affects your ... The cost of a synovial fluid test in Delhi: The Synovial Fluid Test cost varies by region and facility. So constantly get ...
Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of...
Microscopic measurement of inflammation in synovial tissue may be important in studies of clinical status, prognosis and ... synovial membrane. Knee synovial membrane samples from 16 patients with RA, including paired samples taken before and after ... Synovial Fluid / immunology* * T-Lymphocytes / physiology* Substances * Antibodies, Monoclonal * Antigens, CD * Antigens, ... Microscopic measurement of inflammation in synovial tissue may be important in studies of clinical status, prognosis and ...
The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis |...
... resulting from complement activation were immunoassayed in synovial fluid from subjects with healthy knees (reference), OA, ... From: The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis ... using analysis of covariance of log10-transformed concentrations with adjustment for days between the injury and synovial fluid ...
Synovial Fluid For Mycobacterium Tuberculosis (AFB) C/S Online | Price In Pakistan
What is Synovial Fluid and why is Synovial Fluid so important. Learn here
Synovial fluid lubricates the cartilage that cushions the unions of our bones. ... Synovial fluid is the highest-grade lubricant in the world. ... Synovial fluid is the highest-grade lubricant in the world. ... It can be mixed with glucosamine and chondroitin supplements to help restore the joints and the synovial fluid that lubricates ... The more that you condition your body to produce new synovial fluid by stimulating the production with Hyaluronic Acid, the ...
Table 1 - Case Manifestations and Public Health Response for Outbreak of Meningococcal W Disease, Central Australia, 2017 -...
CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis Patients - ACR Meeting Abstracts
CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis Patients. Anastasiya Muntyanu1, Fatima Abji2, Kun Liang3 ... Methods: Synovial. fluid (SF) was obtained from patients with PsA, osteoarthritis (OA) and gout. undergoing routine joint ... Muntyanu A, Abji F, Liang K, Chandran V, Gladman D. CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis ... acrabstracts.org/abstract/cxcl10-expression-is-elevated-in-synovial-fluid-of-psoriatic-arthritis-patients/. Accessed December 1 ...
J Tests - HSE.ie
BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential...
BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential ... Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis.. *A. Yavorskyy, A. hernandez-Santana ... to quantify calcium from crystals isolated from synovial fluid samples as a means of identifying the presence of BCP and, hence ... The data suggest that induction of synovial COX-2-produced PGE(2) is one mechanism by which IL-1 beta modulates cartilage ...
BMP-4, TGF-ß and Smad3 as Modulators of Synovial Fluid Cells Viability. | Rev Bras Ortop (Sao Paulo);57(2): 314-320, 2022 Apr....
Objective Our goal was to evaluate the modulation of the synovial fluid cells (SFC) from patients with and without ... BMP-4, TGF-ß and Smad3 as Modulators of Synovial Fluid Cells Viability. ... BMP-4, TGF-ß and Smad3 as Modulators of Synovial Fluid Cells Viability. ... Methods Synovial fluid was collected from patients submitted to knee arthroscopy or replacement and were centrifuged to isolate ...
MembraneJointsCartilageRheumatoid arthritisEquine synovialIMSEAR at SEAROTissuesKneeLubricantPeriprosthetic joint infectionInflammationOsteoarthritisTendonsSerumPolymerase chain reBonesEffusionAspirationBoneBursaeCapsuleLeukocyteInflammatorySensitivityCerebrospinal fluidInfectionSynovitisCrystalsBody FluidsSepticTissue samplesReduce frictionGastricSamplesPatientsSpecificityEffusionsAntibioticsUltrasoundAnalysisSheathBloodSacsPathogen
Membrane25
- The synovial membrane is the inner membrane of tissue that lines a joint. (medlineplus.gov)
- The synovial membrane secretes synovial fluid which serves to lubricate the joint. (medlineplus.gov)
- 1. viscid lubricating fluid secreted by the membrane lining joints and tendon sheaths etc. (freedictionary.org)
- 1913 Webster] Synovial capsule , a closed sac of synovial membrane situated between the articular surfaces at diarthrodial joints. (freedictionary.org)
- Synovial membrane , the dense and very smooth connective tissue membrane which secretes synovia and surrounds synovial capsules and other synovial cavities. (freedictionary.org)
- Besides these synovial fluid and synovial membrane represents a promising source of mesenchymal stem cells, which can be harvested by minimally invasive methods. (uaiasi.ro)
- The aim of this study was to compare quantitative microscopic analysis of inflammation with a semiquantitative grading system in rheumatoid arthritis (RA) synovial membrane. (nih.gov)
- Knee synovial membrane samples from 16 patients with RA, including paired samples taken before and after treatment in nine patients, were immunostained with anti-CD68 and anti-CD3 monoclonal antibodies using standard techniques. (nih.gov)
- Gentamicin concentrations in synovial fluid, synovial membrane, and joint capsule of group 1 horses were significantly lower than concentrations in those samples for horses in groups 2 and 3. (druglib.com)
- Synovial membrane. (clevelandclinic.org)
- others innervate this capsule and reach the synovial membrane. (britannica.com)
- The sensory fibres to the synovial membrane reach it by innervating the fibrous capsule at various points and form wide-meshed networks in the subsynovial layer. (britannica.com)
- They are found wherever the synovial membrane is, being especially abundant in the fatty pads, and are also present over the peripheral (nonarticulating) parts of the articular cartilage , disks, and menisci. (britannica.com)
- From the network of vessels so formed, branches lead to the fibrous capsule and ligaments and to the synovial membrane. (britannica.com)
- Blood vessels to the synovial membrane are accompanied by nerves, and, when these vessels reach the subsynovial membrane, they proliferate to form another anastomotic network from which capillaries go to all parts of the membrane. (britannica.com)
- The ends of the bones are covered in tough cartilage, and lined with synovial membrane, with contains a small amount of synovial fluid as lubricant. (dogshealth.com)
- The outer region is well-vascularized from capillaries branching off the fibrous capsule and synovial membrane. (medscape.com)
- The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE . (bvsalud.org)
- That membrane holds fluid (synovial fluid) in the joint so the bones are lubricated when they move, instead of grinding against each other. (drugfreehelpstore.com)
- Also, since the synovial membrane is responsible for maintaining that fluid, if it becomes unhealthy it may leak. (drugfreehelpstore.com)
- Our aim is to clean the synovial fluid and strengthen the synovial membrane so that the wearing effects and resulting pain changes of its own accord. (drugfreehelpstore.com)
- The spinal cord is protected by spinal fluid and a membrane called dura mater. (axespt.com)
- More extensive joint cleaning can be done using arthroscopic surgical techniques and the infected synovial membrane can be removed as well. (osc-ortho.com)
- After entering the joint, the bacteria colonize the synovial membrane, produce an acute inflammatory response, and reach the synovial fluid. (bvsalud.org)
- The byproducts of inflammation can rapidly destroy the synovial membrane and collagen matrix, thus inhibiting cartilage synthesis. (bvsalud.org)
Joints26
- Synovial fluid is the lubricant that keeps your joints flowing smoothly. (ganeshdiagnostic.com)
- The application for using this beneficial compound to stimulate the replenishment of synovial fluid has been limited to expensive injections directly into the joints by a doctor. (pureha.com)
- It can be mixed with glucosamine and chondroitin supplements to help restore the joints and the synovial fluid that lubricates them. (pureha.com)
- The highest concentrations of this acid in the human body accumulate in joints, skin, and the fluid of your eyes. (pureha.com)
- Inflammation is what causes the synovial fluid in your joints to deteriorate. (pureha.com)
- Most joints, including synovial (fluid-containing) joints and those between vertebrae, which incorporate a disk, can move. (britannica.com)
- Fluid in normal and abnormal ankle joints: amount and distribution as seen on MR images. (qxmd.com)
- The fluids make your joint look larger and puffier compared to your other joints. (clevelandclinic.org)
- These sacks of fluid act like protective cushions between your bones, ligaments and other parts of your joints. (clevelandclinic.org)
- This important tissue lubricates your joints with a sticky liquid called synovial fluid. (clevelandclinic.org)
- There are several reasons why your knee or other joints might swell with fluid. (clevelandclinic.org)
- Although synovial fluid PGE2 content was higher in joints submitted to CO2 distension, lower levels of hemoglobin and leukocytes oxidative burst after surgery indicates that CO2 arthroscopy decreased intra-articular bleeding and activation of infiltrating leukocytes. (scielo.br)
- It is a heterogeneous group of diseases characterised by an adaptive response of synovial joints to a variety of environmental, genetic, and biomechanical stresses. (bmj.com)
- Hyaluronic acid is a component of synovial fluid, the natural lubricant of joints. (medicinenet.com)
- Septic joints, identified by measuring SAA in synovial fluid. (thehorse.com)
- These compounds found in the soft cartilage, tendons, and synovial fluid, are essential to the healthy functioning of tendons and joints, especially with advancing age. (swansonvitamins.com)
- Our joints are protected by capsules containing synovial fluid. (eohima.org)
- Burdock nourishes joint and synovial fluid and decreases toxins in joints and muscles. (drugfreehelpstore.com)
- Synovial fluid, known as joint fluid, brings joint lubrication and healing nutrients to the joints. (jamber.com)
- Research indicates that using heat therapies, such as the Hand Warming Grippie, can aid tremendously with relaxing stiff muscles/joints, increasing blood circulation, and producing and circulating synovial fluid. (jamber.com)
- Chondroitin is made of sugar chains that help the body to maintain fluid and flexibility in the joints. (naturelifenutrition.com)
- Between the joints and bones are cartilage and synovial fluid , allowing the bones to move without grinding against each other. (axespt.com)
- The sterile fluid inside of our joints, called synovial fluid, plays a vital role in lubricating, nourishing and keeping our joints healthy. (osc-ortho.com)
- There was sufficient protease activity in synovial fluid from human joints with osteoarthritis to release TIMP‐3 from the LAP fusion. (brighton.ac.uk)
- These joints are partly movable which allow movement between bones more than a fibrous joint and less than the synovial joint. (winspiremagazine.com)
- When joints are in motion, and doing work, the joint cavity fills with something called synovial fluid (which rests in a thick, almost buttery state, but then 'melts' into a joint lubricant when you move) and it's that fluid that brings water and the rest of the nutrients the joints need. (plumdragonherbs.com)
Cartilage6
- The synovial fluid lubricates the cartilage that cushions the unions of our bones. (pureha.com)
- None, however, go to the articulating part of an articular cartilage, which therefore depends upon the synovial fluid for its nourishment. (britannica.com)
- However, cartilage is avascular and nourished by synovial fluid. (cdc.gov)
- JOINT CARTILAGE: Glucosamine helps form several chemical compounds involved in the creation of articular cartilage and synovial fluid. (naturelifenutrition.com)
- These are made up of two or more articular surfaced bones and are covered by hyaline cartilage and lubricated by synovial fluid. (winspiremagazine.com)
- The purpose of the synovial fluid is to keep the ends of the knee bones apart to protect from wear and tear on the cartilage coverings, it keeps the joint lubricated, it works as a shock absorber, and it blocks cells and substances from passing into the fluid that may be harmful while allowing nutrients to reach the cartilage. (discountdrugsfromcanada.com)
Rheumatoid arthritis4
- IMSEAR at SEARO: Estimation & significance of serum & synovial fluid malondialdehyde levels in rheumatoid arthritis. (who.int)
- Serum and synovial fluid (SF) levels of malondialdehyde (MDA), a marker of free radical induced lipid peroxidation, were estimated in patients of rheumatoid arthritis (RA) and compared with healthy controls and patients of osteoarthritis (OA). (who.int)
- Immunomic analysis of synovial fluid exosomes reveals cirullinated proteins in patients with rheumatoid arthritis. (mpg.de)
- In addition, through their findings that rheumatoid arthritis patients have high levels of IL-6 in their synovial fluid, they unraveled the significant role of IL-6 in rheumatoid arthritis and other disease conditions. (japanprize.jp)
Equine synovial2
- The aim of our study was to evaluate the growth characteristics of equine synovial liquid stem cells harvested from the tarsometatarsal joint during arthroscopic surgery. (uaiasi.ro)
- Our study demonstrated the characteristics of equine synovial fluid derived stem cells, an ideal candidate for veterinary regenerative medicine. (uaiasi.ro)
IMSEAR at SEARO1
- IMSEAR at SEARO: Synovial fluid changes in mycoplasma induced septicaemic polyarthritis of goat kids. (who.int)
Tissues6
- Gentamicin concentrations in synovial fluid and joint tissues during intravenous administration or continuous intra-articular infusion of the tarsocrural joint of clinically normal horses. (druglib.com)
- OBJECTIVE: To compare gentamicin concentrations achieved in synovial fluid and joint tissues during IV administration and continuous intra-articular (IA) infusion of the tarsocrural joint in horses. (druglib.com)
- Joint effusion (a swollen joint) happens when extra fluids flood the tissues around your joint. (clevelandclinic.org)
- Joint effusion is when fluids enter one or more of these tissues. (clevelandclinic.org)
- Ordinarily, there is a little bit of fluid already in the joint tissues. (clevelandclinic.org)
- Markedly obese individuals should have an adjusted dose due to the decreased distribution of extracellular fluids in adipose tissues. (who.int)
Knee5
- Methods Synovial fluid was collected from patients submitted to knee arthroscopy or replacement and were centrifuged to isolate cells from the fluid. (bvsalud.org)
- But, if there are more fluids than usual in your joint, you have effusion (a swollen knee joint). (clevelandclinic.org)
- The synovial fluid aspirated from his knee was turbid with an elevated leukocyte count and a high percentage of polymorphonuclear cells. (cdc.gov)
- This is a kit of 3 x 2ml injections of Hylan, a gel-like fluid made from Hyaluronan that comes from the combs of chickens that can provide up to 6 months of relief from knee pain. (discountdrugsfromcanada.com)
- Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women. (cdc.gov)
Lubricant1
- Synovial fluid is the highest-grade lubricant in the world. (pureha.com)
Periprosthetic joint infection2
- Based on the EBJIS criteria of periprosthetic joint infection, both synovial fluid and at least five reliable tissue samples must be obtained using separate instruments and immediately transferred to the laboratory for culture. (biomedcentral.com)
- Does Use of Lidocaine Affect Culture of Synovial Fluid Obtained to Diagnose Periprosthetic Joint Infection (PJI)? (medscimonit.com)
Inflammation4
- A synovial fluid study is conducted when a joint has discomfort, inflammation, or oedema or when fluid accumulates for unclear reasons. (ganeshdiagnostic.com)
- Taking a fluid sample can assist in pinpointing the source of the inflammation. (ganeshdiagnostic.com)
- Microscopic measurement of inflammation in synovial tissue may be important in studies of clinical status, prognosis and response to treatment. (nih.gov)
- In patients who have synovitis with effusions, synovial fluid analysis reveals signs of mild inflammation, including poor mucin clotting. (medscape.com)
Osteoarthritis5
- Synovial fluid (SF) was obtained from patients with PsA, osteoarthritis (OA) and gout undergoing routine joint aspirations. (acrabstracts.org)
- Determination of calcium in synovial fluid samples as an aid to diagnosing osteoarthritis. (semanticscholar.org)
- Objective Our goal was to evaluate the modulation of the synovial fluid cells (SFC) from patients with and without osteoarthritis (OA) by bone morphogenetic protein 4 (BMP-4), Smad-3 and transforming growth factor beta (TGF-ß). (bvsalud.org)
- The presence of noninflammatory joint fluid helps distinguish osteoarthritis from other causes of joint pain. (medscape.com)
- Other synovial fluid findings that aid in the differentiation of osteoarthritis from other conditions include negative Gram stains and cultures as well as the absence of crystals when fluid is viewed under a polarizing microscope. (medscape.com)
Tendons2
- Bursitis - Bursae are small sacs of synovial fluid throughout the body that cover areas where friction may develop between bones and muscles or tendons. (previant.com)
- They are enclosed in a protective covering called a synovial sheath, which produces a fluid that keeps the tendons lubricated, allowing them to slide easily through the sheath. (srortho.com)
Serum2
- Serum, synovial fluid, and joint tissue samples were collected for measurement of gentamicin at various time points during and 73 hours after initiation of treatment. (druglib.com)
- Four measures were used to evaluate the bioaccessibility of cobalt species if inhaled, using synthetic equivalents of alveolar fluid, interstitial fluid, lysosomal fluid, and human serum. (europa.eu)
Polymerase chain re1
- Researchers used 16S polymerase chain reaction analysis and a synovial fluid bacteriologic analysis and culture to classify synovial fluid samples as having septic arthritis (n=30) or nonseptic arthritis (n=372). (rheumatologyadvisor.com)
Bones2
- Juleen reminds students to articulate through the joint spaces between bones, where synovial fluid is located. (dance-teacher.com)
- It is a kind of synovial joint which allows movement of bones in one plane. (winspiremagazine.com)
Effusion5
- The purpose of the study, according to the investigators, was to verify the interest of mid-infrared spectroscopy to identify synovial fluid samples from patients with septic arthritis vs other causes of joint effusion. (rheumatologyadvisor.com)
- Sonographically detected subacromial/subdeltoid bursal effusion and biceps tendon sheath fluid: reliable signs of rotator cuff tear? (qxmd.com)
- Association of sonographically detected subacromial/subdeltoid bursal effusion and intraarticular fluid with rotator cuff tear. (qxmd.com)
- Swelling may be due to bony deformity such as osteophyte formation, or due to an effusion caused by synovial fluid accumulation. (bmj.com)
- Early in the diagnostic process, X-rays will not be helpful, however ultrasound can reveal abnormally large amounts of joint fluid, called effusion, which causes swelling of the joint. (osc-ortho.com)
Aspiration9
- But the discordance between preoperative aspiration culture and intraoperative synovial fluid culture remains unknown. (biomedcentral.com)
- 2) compared to intraoperative synovial fluid cultures, the sensitivity of preoperative aspiration fluid culture. (biomedcentral.com)
- Then the following question is tried to be answered: Are intraoperative synovial fluid re-cultures necessary if the preoperative aspiration culture is positive? (biomedcentral.com)
- Compared to intraoperative synovial fluid culture, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of preoperative aspiration culture were calculated. (biomedcentral.com)
- The intraoperative synovial fluid re-cultures are necessary if the preoperative aspiration culture is positive and the discordance between preoperative aspiration culture and intraoperative synovial fluid culture should be noted especially when Streptococcus spp. (biomedcentral.com)
- However, to our knowledge, some studies revealed the difference between preoperative aspiration cultures and intraoperative tissue cultures but no studies comprehensively evaluated the concordance between preoperative aspiration culture and intraoperative synovial fluid culture [ 5 ]. (biomedcentral.com)
- However, according to these criteria, a problem was raised: are intraoperative synovial fluid re-cultures necessary if preoperative aspiration culture is positive. (biomedcentral.com)
- If a microorganism of high-virulence was detected in the preoperative aspiration culture, there may be no need to perform intra-op synovial fluid culture again because the PJI pathogen has been identified and extra tests increase the cost of PJI management. (biomedcentral.com)
- Between-groups statistical testing was performed using analysis of covariance of log 10 -transformed concentrations with adjustment for days between the injury and synovial fluid aspiration, age at injury, and sex. (biomedcentral.com)
Bone1
- Increased and imbalanced dispersion of joint forces, combined with a concentration of stresses and synovial fluid infiltration into the subchondral bone, can lead to reduced healing capacity and abnormalities within the underlying cancellous bone. (faoj.org)
Bursae1
- Presence and amount of fluid were assessed in the ankle joint recesses, adjacent bursae, and tendon sheaths. (qxmd.com)
Capsule2
- A bony spur toward the volar side was covered with synovial fluid from a pinhole-sized perforation of the capsule. (hindawi.com)
- The combination of direct friction from the DRUJ spur and the matrix metalloproteinases in the synovial fluid from the perforation of the DRUJ capsule may have caused the spontaneous flexor tendon rupture. (hindawi.com)
Leukocyte2
- In conclusion, results of this study confirm the high level of sensitivity and specificity of synovial leukocyte esterase for analysis of prosthetic joint illness, also suggesting the need to assess a panel of markers to optimize analysis of these infections. (bioinf.org)
- Synovial fluid analysis Sensitivity, specificity, and positive and negative predictive ideals of synovial SB366791 alpha defensin, leukocyte esterase, CRP, and WBC count are reported in Table 2. (bioinf.org)
Inflammatory3
- Large quantities of fibronectin (Fn) are present in inflammatory synovial fluid. (jci.org)
- Inflammatory synovial fluid Fn, while indistinguishable from plasma Fn on the basis of reactivity to polyclonal antibodies, displays alterations in molecular size and charge. (jci.org)
- PURPOSE: To assess comparatively the inflammatory response that follows CO2 or Ringer's lactate joint capsular distension of horses submitted to experimental arthroscopy METHODS: Each animal was submitted to a bilateral tarsocrural arthroscopy employing gas distention in one joint and fluid distention in the contralateral joint. (scielo.br)
Sensitivity2
- Send joint fluid for fluid analysis, including cell count and differential, Gram stain, culture and sensitivity, and microscopic analysis for crystals. (medscape.com)
- Level of sensitivity, specificity, and positive and negative predictive ideals of synovial markers. (bioinf.org)
Cerebrospinal fluid1
- He was intubated, a lumbar puncture was performed, and cerebrospinal fluid, or CSF, was collected before his transfer to the intensive care unit. (cdc.gov)
Infection2
- From the "Illustrated Manual for the Recognition and Diagnosis of Certain Animal Diseases", published in 1982, by the Mexico-United States Commission for the Prevention of Foot and Mouth Disease, this photograph was captured at a bovine necropsy, and depicts the interior of a joint in which excessive synovial fluid, as well as bits of fibrin had accumulated, in the case of a contagious bovine pleuropneumonia (CBPP) infection. (cdc.gov)
- If Septic Arthritis is suspected, it is important to quickly determine if a pathogen is present in the synovial fluid and to then isolate the microorganism that is causing the infection. (osc-ortho.com)
Synovitis1
- RESULTS: The use of CO2 for arthroscopy causes an acute and mild synovitis alike to the liquid capsular distension, showing similar synovial fluid increase of leukocytes, TP, and TNF-α. (scielo.br)
Crystals4
- Even in the presence of crystals in the joint fluid, blood cultures are indicated if any sign of systemic toxicity is present. (medscape.com)
- Analysis of synovial fluid for crystals should ideally be done within 24-48 hours after collection. (medscape.com)
- BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13. (semanticscholar.org)
- This article investigates the use of o-cresolphthalein complexone (OCP), a colorimetric reagent, to quantify calcium from crystals isolated from synovial fluid samples as a means of identifying the presence of BCP and, hence, improving the diagnosis of OA. (semanticscholar.org)
Body Fluids1
- Tale 4.12: Practice following spill of blood and body fluids. (researchwap.org)
Septic4
- Optical fiber infrared spectroscopy is a quick and reliable method for discriminating between septic and nonseptic fluids, according to data presented at the European League Against Rheumatism (EULAR) Congress, held in Amsterdam, June 13-16, 2018. (rheumatologyadvisor.com)
- The [septic arthritis] diagnosis is based on the cytobacteriological examination of the synovial fluid, but direct bacteriological examination is insensitive and the result of the culture is obtained only after several days," the researchers explained. (rheumatologyadvisor.com)
- Spectral variables, which allowed determination of septic and nonseptic arthritis, were used to develop an algorithm that was later validated with non-frozen synovial fluids from a different research center. (rheumatologyadvisor.com)
- Drainage of infected joint fluid is required for the treatment of septic arthritis. (osc-ortho.com)
Tissue samples1
- If your veterinarian has cause for concern based on initial examination, he or she may recommend further tests, including diagnostic nerve or joint blocks, radiographs, nuclear scanning, ultrasound, arthroscopy or examination of blood, synovial fluid and tissue samples. (aaep.org)
Reduce friction1
- Our bodies use synovial fluid to reduce friction, and machines use lubricating fluids for the same purpose. (teachengineering.org)
Gastric1
- Employing gastric and intestinal fluid surrogates for the assessment of bioaccessibility of cobalt species is useful in predicting the bioavailability of cobalt compounds and determining doses related to health risks caused by their ingestion. (europa.eu)
Samples2
Patients4
- It is used to restore fluid in eye surgery patients. (pureha.com)
- This study confirms previous reports of elevated synovial CXCL10 and IL-17A in PsA patients. (acrabstracts.org)
- Muntyanu A, Abji F, Liang K, Chandran V, Gladman D. CXCL10 Expression Is Elevated in Synovial Fluid of Psoriatic Arthritis Patients [abstract]. (acrabstracts.org)
- In our studies, imatinib attenuated PDGFR signaling in fibroblast-like synoviocytes (FLSs) and TNF-α production in synovial fluid mononuclear cells (SFMCs) derived from human RA patients. (elsevier.com)
Specificity1
- Taking into consideration a cutoff worth of 3000 cells/L, specificity and awareness of synovial WBC count number had been 93.7% and 91.2%, respectively. (bioinf.org)
Effusions1
- The synovial effusions were exudative in nature with increased volume. (who.int)
Antibiotics2
- Fluid can be drawn off the affected joint with a hypodermic needle often (if not daily) and the joint will be injected or "washed out" with antibiotics and saline, to kill bacteria. (osc-ortho.com)
- Cellulitis overlying the joint: If arthrocentesis is performed, the patient should be admitted for the administration of intravenous antibiotics, even if the synovial fluid is not suggestive of infectious arthritis. (medscape.com)
Ultrasound1
- Three dimensional ultrasound volumetric assessment of the synovial fluid in the ankle and hindfoot: Technique and normative data]. (qxmd.com)
Analysis6
- Minute quantities of fluid in the shaft or hub of the needle are sufficient for synovial fluid analysis. (medscape.com)
- Since biochemical differences between plasma and synovial fluid fibronectins might be in part due to differences in glycosylation we have compared the carbohydrate composition of plasma Fn, synovial fluid Fn, and Fn from synoviocyte conditioned medium by biochemical assay, glycopeptide analysis, and binding to a series of lectins. (jci.org)
- 1). Among Gram-negative bacilli, were isolated in one sample each, as well as and and were isolated from synovial fluid tradition of two individuals in Group B, but, since none of the additional criteria for PJI analysis was fulfilled, they were regarded as contaminants. (bioinf.org)
- A joint fluid analysis test is used to determine the source of your symptoms. (ganeshdiagnostic.com)
- Synovial joint fluid analysis is a series of tests your physician might use to diagnose joint issues. (ganeshdiagnostic.com)
- Synovial fluid analysis is sometimes used to detect joint diseases. (ganeshdiagnostic.com)
Sheath3
- Fluid was detected in the anterior recess in 20 ankles (bilaterally in eight volunteers), retrocalcaneal bursa in 30 ankles (bilaterally in 12 volunteers), posterior tibial tendon sheath in 46 ankles (bilaterally in 19 volunteers), and common peroneal tendon sheath in seven ankles (bilaterally in three volunteers). (qxmd.com)
- On average, symmetry was present for only the retrocalcaneal bursal and peroneal tendon sheath fluid. (qxmd.com)
- US of the hindfoot and ankle commonly depicts articular, bursal, and tendon sheath fluid in asymptomatic volunteers. (qxmd.com)
Blood5
- In crystal arthritis, the white blood cell (WBC) count in the synovial fluid is usually 10,000-70,000/µL. (medscape.com)
- Sulfur passes from the blood to the synovial fluid and from there to the chondrocytes. (britannica.com)
- She takes the fluid systems-blood, synovial and interstitial-as the basis for a whole exploration of movement," she says. (dance-teacher.com)
- You can do this by increasing blood circulation and synovial fluid circulation in your hands. (jamber.com)
- Occasionally, a digital mucous cyst may burst, releasing thick, jelly-like, sticky fluid that is clear, although in some cases it may be slightly yellowy or tinged with blood. (foot-pain-explored.com)
Sacs1
- They look like small fluid-filled sacs, usually less than 1cm in diameter. (foot-pain-explored.com)
Pathogen2
- When this fluid is infected by a pathogen, its sterility is lost and it becomes an internal Petri dish in which bacteria or other agents quickly multiply. (osc-ortho.com)
- If the fluid is indeed infected with a microorganism, treatment will depend on the type of pathogen found. (osc-ortho.com)