Synephrine: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.Evodia: A plant genus of the family RUTACEAE which is used in Chinese medicine (DRUGS, CHINESE HERBAL). Evodiamine and other quinazoline alkaloids (QUINAZOLINES) are obtained from the fruit of E. ruticarpa.2-Hydroxyphenethylamine: Simple amine found in the brain. It may be modulator of sympathetic functions. Its derivatives are adrenergic agonists and antagonists. It is also used in chemical industry.Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.Adrenergic Antagonists: Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.Citrus: A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Injections: Introduction of substances into the body using a needle and syringe.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Hesperidin: A flavanone glycoside found in CITRUS fruit peels.Glycogenolysis: The release of GLUCOSE from GLYCOGEN by GLYCOGEN PHOSPHORYLASE (phosphorolysis). The released glucose-1-phosphate is then converted to GLUCOSE-6-PHOSPHATE by PHOSPHOGLUCOMUTASE before entering GLYCOLYSIS. Glycogenolysis is stimulated by GLUCAGON or EPINEPHRINE via the activation of PHOSPHORYLASE KINASE.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Flavanones: A group of FLAVONOIDS characterized with a 4-ketone.Distillation: A chemical process for separating the components of a liquid mixture by boiling and collecting condensed vapors.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Advertising as Topic: The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Food Labeling: Use of written, printed, or graphic materials upon or accompanying a food or its container or wrapper. The concept includes ingredients, NUTRITIONAL VALUE, directions, warnings, and other relevant information.Weight Loss: Decrease in existing BODY WEIGHT.Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Tooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Administration, Intranasal: Delivery of medications through the nasal mucosa.Nasal Lavage Fluid: Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.Nasal Polyps: Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.Basal Metabolism: Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Rest: Freedom from activity.Calorimetry, Indirect: Calculation of the energy expenditure in the form of heat production of the whole body or individual organs based on respiratory gas exchange.Flavoring Agents: Substances added to foods and medicine to improve the quality of taste.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Dydrogesterone: A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.Weight Lifting: A sport in which weights are lifted competitively or as an exercise.Coronary Vasospasm: Spasm of the large- or medium-sized coronary arteries.Stanozolol: A synthetic steroid that has anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1194)Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Kinetics: The rate dynamics in chemical or physical systems.Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Dosage Compensation, Genetic: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Time Factors: Elements of limited time intervals, contributing to particular results or situations.

Conversion of (+/-)-synephrine into p-hydroxyphenylacetaldehyde by Arthrobacter synephrinum. A novel enzymic reaction. (1/36)

A partically purified enzyme from Arthrobacter synephrinum was found to catalyse the conversion of (+/-)-synphrine into p-hydroxyphrenylacetaldehyde and methylamine. The enzyme is highly specific for synephrine and is distinctly different from monoamine oxidase.  (+info)

Hemodynamic effects of synephrine treatment in portal hypertensive rats. (2/36)

Synephrine, a sympathomimetic alpha1-adrenoceptor agonist, has been shown to induce dose-dependent portal hypotensive effects after acute intravenous infusion. The present study was undertaken to investigate the hemodynamic effects of 8-day administration of synephrine in portal hypertensive rats. Portal hypertension was induced by either partial portal vein ligation (PVL) or bile duct ligation (BDL). Portal hypertensive rats were allocated into one of two groups: vehicle group (0.1 N HCl, 0.5 ml/12 h) or synephrine group (1 mg/kg per 12 h), with 7 rats in each group. Synephrine or vehicle was administered by gavage into PVL and BDL rats for 8 consecutive days. Systemic as well as splanchnic hemodynamic parameters were measured thereafter. Synephrine significantly ameliorated the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats (-13.5% and -10.1%, respectively), portal tributary blood flow (-19.5% and -20.4%) and cardiac index (-12.1% and -18.8%) were significantly reduced, while mean arterial pressure (10.4% and 23.4%) and systemic (26.3% and 51.0%) as well as portal territory (47.1% and 67.7%) vascular resistance were enhanced by treatment of synephrine as compared with vehicle treatment. Our results showed that eight-day administration of synephrine exerted beneficial hemodynamic effects in two models of portal hypertensive rats.  (+info)

Microbial metabolism of phenolic amines: degradation of dl-synephrine by an unidentified arthrobacter. (3/36)

Microorganisms capable of degrading dl-synephrine were isolated from soil of Citrus gardens by enrichment culture, with dl-synephrine as the sole source of carbon and nitrogen. An organism which appears to be an arthrobacter, but which cannot be identified with any of the presently recognized species was predominant in these isolates. It was found to metabolize synephrine by a pathway involving p-hydroxyphenylacetaldehyde, p-hydroxyphenylacetic acid, and 3,4-dihydroxyphenylacetic acid as intermediates. Some of the enzymes of this pathway were demonstrated in cell-free extracts. An aromatic oxygenase, which could also be readily obtained in a cell-free system, was found to degrade 3,4-dihydroxyphenylacetic acid by meta cleavage.  (+info)

LEAKAGE OF TRANSMITTERS IN SALIVARY GLANDS. (4/36)

Salivary secretion evoked by sympathetic stimulation or by injection of guanethidine, adrenaline or synephrine is slightly reduced by parasympathetic antagonists in doses which abolish the secretory responses to stimulation of the parasympathetic nerve. Similarly, an adrenaline antagonist caused a small diminution of the salivary flow elicited by parasympathetic stimulation or by injection of methacholine chloride. Secretion caused by pilocarpine could be accelerated by physostigmine. We conclude that transmitter leaks in subliminal concentrations, as far as secretion is concerned, from the sympathetic and parasympathetic postganglionic nerve endings.  (+info)

Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single-laboratory validation. (5/36)

A method has been developed to quantify synephrine in bitter orange raw material, extracts, and dietary supplements. Single-laboratory validation has been performed on the method to determine the repeatability, accuracy, selectivity, limit of detection/limit of quantification (LOQ), ruggedness, and linearity for p-synephrine and 5 other biogenic amines: octopamine, phenylephrine (m-synephrine), tyramine, N-methyltyramine, and hordenine, which may be present in bitter orange. p-Synephrine was found to be the primary biogenic amine present in all materials tested, accounting for >80% of the total biogenic amine content in all samples except a finished product. Repeatability precision for synephrine was between 1.48 and 3.55% RSD. Synephrine recovery was between 97.5 and 104%. The minor alkaloids were typically near the LOQ of the method (300-900 microg/g) in the test materials, and between-day precision for the minor compounds was poor because interferences could sometimes be mistakenly identified as one of the minor analytes. Recoveries of the minor components ranged from 99.1 to 103% at approximately 6000 microg/g spike level, to 90.7 to 120% at 300 microg/g spike level.  (+info)

Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark). (6/36)

The lipolysis induced by Satsuma mandarin orange (Citrus unshu Mark) was investigated using rat fat cells. Peel or segment wall extract from Satsuma mandarin orange induced the lipolysis in a concentration-dependent manner, whereas juice sac extract did not induce the lipolysis. High concentration of synephrine, which is an adrenergic amine, was detected in the peel or segment wall extract, whereas it was not detected in the juice sac extract. The segment wall extracts from Iyokan and orange had high lipolytic activity, whereas the extracts from grapefruit and lemon did not have lipolytic activity. The beta-antagonist inhibited the lipolysis elicited by the segment wall extract from Satsuma mandarin orange, whereas alpha-antagonist did not inhibit the lipolysis induced by the segment wall. The lipolysis induced by the segment wall was considerably higher in the visceral fat cells when compared to the subcutaneous fat cells. These results suggest that the segment wall, an edible fraction, from Satsuma mandarin orange might be useful as a functional food, especially as a fat-reducing material.  (+info)

Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. (7/36)

 (+info)

Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects. (8/36)

 (+info)

  • While synephrine and many of the components that can be found in zhi shi appear to be the same as the ones found in ephedrine, synephrine is believed to work as a stimulant without leaving the negative side effects that inflict the central nervous system like ephedra does. (testosteronepowdersource.com)
  • Nevertheless, it was eventually imagined that will solutions that contain synephrine and poisonous tangerine showcase damaging cardiovascular system unintended side effects. (healtherapyinc.com)
  • The theory is that because synephrine acts as a stimulant, it is believed to have some of the same effects in terms of an energy boost, as well as increasing metabolic rates and suppressing appetites. (testosteronepowdersource.com)
  • Synephrine is lime fruits of the main active ingredient, which can effectively prevent excess energy (heat accumulation), by the wind qi,warm the stomach stimulates the appetite and speeds up metabolism.It is also a mild fragrance expectorant agent, a neurological tranquilizers and laxative treatment of constipation. (testosteronepowdersource.com)
  • This can include increasing metabolic rates, an increase of caloric expenditure (the quickness in which you lose calories), increasing of energy levels, as well as synephrine acting as a fat burner and as a promoter of weight loss. (testosteronepowdersource.com)
  • Thirty four percent of subjects exposed to Sinarest nasal responded that flight they would not take the drug again, whereas only 5% of subjects exposed to ir Neo - synephrine 12 hour shared ownership that ordinary opinion. (searchenginerockstar.com)
  • Accordingly, synephrine impacts the adrenal system of the human body and increases basal metabolic rate, which accounts for up to 70% of your daily caloric expenditure. (passionchemical.com)
  • Citrus Aurantium Extractproduct Name: Citrus Aurantium P. E. Plant Origin: Citrua Aurantium Specification: Cta-synephrine 4%, 6%, 10%, 30% 96%, 98% Hplc Synephrine Is. (busytrade.com)
  • Tom qab tag nrho, peb yuav txais yuav tam sim no extraction tshuab thiab tau siab txheem ntawm synephrine los ntawm citrus li 98% min soj ntsuam los ntawm HPLC. (gmp-factory.com)
  • Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. (wikipedia.org)
  • On the other hand, Synephrine is an alkaloid that naturally occurs in several plants and animals. (thedietplan.net)
  • Synephrine is an alkaloid (a pharmacologically active class of nitrogen-containing chemical compounds). (mevolv.com)
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  • To take advantage of the metabolic and energy properties of Synephrine powder, it is best taken first thing in the morning or 15 - 30 minutes before exercise. (aasraw.com)
  • It just means you shouldn't supplement only with Synephrine powder if you really want to see improvements. (aasraw.com)
  • Besides the ability to suppress appetite, Synephrine powder shows zero evidence of being able to burn fat itself. (aasraw.com)
  • Therefore, Synephrine powder cannot be considered to be a fat burner. (aasraw.com)
  • By taking Synephrine powder with a fat burner though, you will feel that you will be less tempted to snack during your day as you will remain fuller for longer and have almost zero desire to eat beyond your daily means. (aasraw.com)
  • Synephrine powder is still undergoing testing and some results show that when consumed, it can have possible side effects, such as headaches, nausea, and upset stomach feelings. (aasraw.com)
  • If you poke around on the Internet for an answer, you'll find dire warnings that Synephrine powder can increase the risk for high blood pressure, fainting, heart attack, stroke, and 'other severe side effects. (aasraw.com)
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  • In other cases the tumors become much, buy synephrine diet pills, buy synephrine powder, without local lesions in the fcetus and congenitally infected new born. (ip-web-law.com)
  • Be sure to only consider purchasing bitter orange in salt powder form, preferably with the word 'Synephrine' literally written on the container. (vaxxenlabs.com)
  • Synephrine is a substance found in plants that appears to mimic the fight-or-flight hormones epinephrine and norepinephrine. (livestrong.com)
  • P -Synephrine ( P -hydroxy-α-{methylaminomethyl}benzylalcohol) is a protoalkaloid compound and trace amine that can be endogenously produced in the human body, or can be found in high levels in the bitter orange ( citrus aurantium ) traditional chinese medicine and supplement. (examine.com)
  • SYNEPHRINE ;4-hydroxy-alpha-(methylaminomethyl)benzyl alcohol;AKOS NCG1-0008. (flemtam.com)
  • SYNEPHRINE ;4-hydroxy-alpha-(methylaminomethyl)benzyl alcohol;AKOS NCG1-0008;1-[4-HYDROXYPHENYL]-2-METHYLAMINOETHANOL;AURORA KA-6561. (flemtam.com)
  • Separation and extraction methods At present, the extraction and separation method of high purity Synephrine is not mature, and the commonly used method is mainly cationic bunch of ester exchange method and hydrochloric acid percolation method, etc. (sellsteroid.com)
  • Synephrine stimulates both a-adrenergic and ß-adrenergic receptors in the body. (nutritionexpress.com)
  • Studies have shown synephrine specifically stimulates ß3-adrenergic receptors, which regulate fat breakdown, whereas stimulation of ß1-and ß2-adrenergic receptors is linked with cardiac effects. (nutritionexpress.com)
  • Synephrine is lime fruits of the main active ingredient, which can effectively prevent excess energy (heat accumulation), by the wind qi, warm the stomach stimulates the appetite and speeds up metabolism. (opencroquet.org)
  • Synephrine is lime fruits of the main active ingredient, which can effectively prevent excess energy (heat accumulation), by the wind qi,warm the stomach stimulates the appetite and speeds up metabolism.It is also a mild fragrance expectorant agent, a neurological tranquilizers and laxative treatment of constipation. (testosteronepowdersource.com)
  • The stimulatory effect of R-(-)-p-synephrine on [3H]noradrenaline release was inhibited by nisoxetine (100 nM), but tetrodotoxin (1 microM) and elimination of extracellular calcium had no effect. (amphetamines.org)
  • The similarity of naming between m-synephrine and the unsubstituted form, synephrine, is a source of some confusion however m-synephrine refers to a related drug more commonly known as phenylephrine. (drugbank.ca)
  • The synephrine compounds found within Citrus aurantium have adrenergic effects, that is they increase the activity of epinephrine (adrenalin) and norepinephrine (noradrenalin), and therefore have the potential to suppress appetite, increase lipolysis (fat breakdown), but because they are closely related to ephedrene may also carry some health risks (Fugh-Berman and Myers, 2004). (strengthandfitnessuk.com)
  • Bitter orange is a type of orange that contains synephrine, a compound that may be effective in reducing appetite. (healthline.com)
  • Though it's just as effective as Synephrine in appetite suppression and stimulating the metabolism, it's considered far more harmful to your cardiovascular system. (vaxxenlabs.com)
  • SNS Synephrine HCI will give you energy and suppress your appetite. (illpumpyouup.com)
  • The FEI urges stakeholders to be vigilant of possible sources of synephrine in the horse's environment and implement management practices to prevent contamination or inadvertent ingestion of the substance. (horsesportireland.ie)
  • Synephrine is a kind of biological active substance, mainly extracted from the orange, tangerine peel, green husk and rutaceae plants, is a traditional Chinese medicine and plays an important role of frutus aurantii immaturus effective component. (opencroquet.org)
  • Synephrine is an increasingly used substance that our bodies naturally create. (vaxxenlabs.com)
  • But because the Synephrine has the similar structure to that of jute alkali has excited central nervous, the potential side effects of cardiovascular disease, in recent years it is limited to use in the United States, Canada and other countries. (opencroquet.org)
  • It will usually be found possible to perform end to end, synephrine hcl dose, synephrine health benefits, larly obliterating endarteritis is common. (ip-web-law.com)
  • M-synephrine is used as a nasal decongestant and also to dilate pupils during eye surgery. (selfhacked.com)
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