The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Use of electric potential or currents to elicit biological responses.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
A class of ionotropic glutamate receptors characterized by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid).
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
The function of opposing or restraining the excitation of neurons or their target excitable cells.
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
The most common inhibitory neurotransmitter in the central nervous system.
Hyperpolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during NEUROTRANSMISSION. They are local changes which diminish responsiveness to excitatory signals.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool.
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.
The synapse between a neuron and a muscle.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Drugs that bind to and activate excitatory amino acid receptors.
Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.
Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.
Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.
Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Postsynaptic potentials generated from a release of neurotransmitters from a presynaptic nerve terminal in the absence of an ACTION POTENTIAL. They may be m.e.p.p.s (miniature EXCITATORY POSTSYNAPTIC POTENTIALS) or m.i.p.p.s (miniature INHIBITORY POSTSYNAPTIC POTENTIALS).
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Refers to animals in the period of time just after birth.
The voltages across pre- or post-SYNAPTIC MEMBRANES.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.
A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.
Neurotransmitter receptors located on or near presynaptic terminals or varicosities. Presynaptic receptors which bind transmitter molecules released by the terminal itself are termed AUTORECEPTORS.
One of four subsections of the hippocampus described by Lorente de No, located furthest from the DENTATE GYRUS.
A class of ionotropic glutamate receptors characterized by their affinity for KAINIC ACID.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1)
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.
Elements of limited time intervals, contributing to particular results or situations.
Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids.
Neurons which activate MUSCLE CELLS.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
A subset of GABA RECEPTORS that signal through their interaction with HETEROTRIMERIC G-PROTEINS.
An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
CALCIUM CHANNELS located in the neurons of the brain.
Axons of certain cells in the DENTATE GYRUS. They project to the polymorphic layer of the dentate gyrus and to the proximal dendrites of PYRAMIDAL CELLS of the HIPPOCAMPUS. These mossy fibers should not be confused with mossy fibers that are cerebellar afferents (see NERVE FIBERS).
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
CALCIUM CHANNELS located within the PURKINJE CELLS of the cerebellum. They are involved in stimulation-secretion coupling of neurons.
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Carbamate derivative used as an insecticide, acaricide, and nematocide.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
Derivatives of BUTYRIC ACID that contain one or more amino groups attached to the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.
Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Drugs that bind to but do not activate GABA-A RECEPTORS thereby blocking the actions of endogenous or exogenous GABA-A RECEPTOR AGONISTS.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Cytoskeleton specialization at the cytoplasmic side of postsynaptic membrane in SYNAPSES. It is involved in neuronal signaling and NEURONAL PLASTICITY and comprised of GLUTAMATE RECEPTORS; scaffolding molecules (e.g., PSD95, PSD93), and other proteins (e.g., CaCMKII).
A broad-spectrum excitatory amino acid antagonist used as a research tool.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.
Venoms of arthropods of the order Araneida of the ARACHNIDA. The venoms usually contain several protein fractions, including ENZYMES, hemolytic, neurolytic, and other TOXINS, BIOLOGICAL.
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
The output neurons of the cerebellar cortex.
Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel and are usually inhibitory.
Spiny processes on DENDRITES, each of which receives excitatory input from one nerve ending (NERVE ENDINGS). They are commonly found on PURKINJE CELLS and PYRAMIDAL CELLS.
A neurotoxic peptide, which is a cleavage product (VIa) of the omega-Conotoxin precursor protein contained in venom from the marine snail, CONUS geographus. It is an antagonist of CALCIUM CHANNELS, N-TYPE.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.
Neural tracts connecting one part of the nervous system with another.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
GRAY MATTER situated above the GYRUS HIPPOCAMPI. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called GRANULE CELLS, whose AXONS pass through the polymorphic layer ending on the DENDRITES of PYRAMIDAL CELLS in the hippocampus.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells.
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.
Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.
OXAZINES with a fused BENZENE ring.
A pathway of fibers that originates in the lateral part of the ENTORHINAL CORTEX, perforates the SUBICULUM of the HIPPOCAMPUS, and runs into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the DENTATE GYRUS where the pathway terminates. It is also known as the perforating fasciculus.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Catalyzes the ATP-dependent PHOSPHORYLATION of GMP to generate GDP and ADP.
Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Clusters of neuronal cell bodies in invertebrates. Invertebrate ganglia may also contain neuronal processes and non-neuronal supporting cells. Many invertebrate ganglia are favorable subjects for research because they have small numbers of functional neuronal types which can be identified from one animal to another.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A subsection of the hippocampus, described by Lorente de No, that is located between the HIPPOCAMPUS CA2 FIELD and the DENTATE GYRUS.
A family of vesicular neurotransmitter transporter proteins that sequester the inhibitory neurotransmitters GLYCINE; GAMMA-AMINOBUTYRIC ACID; and possibly GAMMA-HYDROXYBUTYRATE into SECRETORY VESICLES.
A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
The observable response an animal makes to any situation.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A superfamily of various freshwater CRUSTACEA, in the infraorder Astacidea, comprising the crayfish. Common genera include Astacus and Procambarus. Crayfish resemble lobsters, but are usually much smaller.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
A family of vesicular transport proteins characterized by an N-terminal transmembrane region and two C-terminal calcium-binding domains.
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)
A vesicular glutamate transporter protein that is predominately expressed in TELENCEPHALON of the BRAIN.
A family of hexahydropyridines.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Central gray matter surrounding the CEREBRAL AQUEDUCT in the MESENCEPHALON. Physiologically it is probably involved in RAGE reactions, the LORDOSIS REFLEX; FEEDING responses, bladder tonus, and pain.
A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
Purine bases found in body tissues and fluids and in some plants.
The largest portion of the CEREBRAL CORTEX in which the NEURONS are arranged in six layers in the mammalian brain: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multiform layers.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Specialized junctions between NEURONS which connect the cytoplasm of one neuron to another allowing direct passage of an ion current.
Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.
Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.
The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.
Common name for the only family (Petromyzontidae) of eellike fish in the order Petromyzontiformes. They are jawless but have a sucking mouth with horny teeth.
NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.
Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.
Plant extracts from several species, including genera STRYCHNOS and Chondodendron, which contain TETRAHYDROISOQUINOLINES that produce PARALYSIS of skeletal muscle. These extracts are toxic and must be used with the administration of artificial respiration.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Physical forces and actions in living things.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. They share a homologous SNARE motif. The SNARE proteins are divided into subfamilies: QA-SNARES; QB-SNARES; QC-SNARES; and R-SNARES. The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e., SNAPs (no relation to SNAP 25.)
Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Common name for Carassius auratus, a type of carp (CARPS).
A species of European freshwater LEECHES used for BLOODLETTING in ancient times and also for LEECHING in modern times.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals.
A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.
CALCIUM CHANNELS located in the neurons of the brain. They are inhibited by the marine snail toxin, omega conotoxin MVIIC.
The ability of a substrate to allow the passage of ELECTRONS.
Mice which carry mutant genes for neurologic defects or abnormalities.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.
Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
The largest and uppermost of the paravertebral sympathetic ganglia.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (1/11810)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine. (2/11810)

In a slice preparation of rat visual cortex, we discovered that paired-pulse stimulation (PPS) elicits a form of homosynaptic long-term depression (LTD) in the superficial layers when carbachol (CCh) or norepinephrine (NE) is applied concurrently. PPS by itself, or CCh and NE in the absence of synaptic stimulation, produced no lasting change. The LTD induced by PPS in the presence of NE or CCh is of comparable magnitude with that obtained with prolonged low-frequency stimulation (LFS) but requires far fewer stimulation pulses (40 vs 900). The cholinergic facilitation of LTD was blocked by atropine and pirenzepine, suggesting involvement of M1 receptors. The noradrenergic facilitation of LTD was blocked by urapidil and was mimicked by methoxamine, suggesting involvement of alpha1 receptors. beta receptor agonists and antagonists were without effect. Induction of LTD by PPS was inhibited by NMDA receptor blockers (completely in the case of NE; partially in the case of CCh), suggesting that one action of the modulators is to control the gain of NMDA receptor-dependent homosynaptic LTD in visual cortex. We propose that this is a mechanism by which cholinergic and noradrenergic inputs to the neocortex modulate naturally occurring receptive field plasticity.  (+info)

Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network. (3/11810)

Paired intracellular recordings have been used to examine the activity-dependent plasticity and neuromodulator-induced metaplasticity of synaptic inputs from identified inhibitory and excitatory interneurons in the lamprey spinal cord. Trains of spikes at 5-20 Hz were used to mimic the frequency of spiking that occurs in network interneurons during NMDA or brainstem-evoked locomotor activity. Inputs from inhibitory and excitatory interneurons exhibited similar activity-dependent changes, with synaptic depression developing during the spike train. The level of depression reached was greater with lower stimulation frequencies. Significant activity-dependent depression of inputs from excitatory interneurons and inhibitory crossed caudal interneurons, which are central elements in the patterning of network activity, usually developed between the fifth and tenth spikes in the train. Because these interneurons typically fire bursts of up to five spikes during locomotor activity, this activity-dependent plasticity will presumably not contribute to the patterning of network activity. However, in the presence of the neuromodulators substance P and 5-HT, significant activity-dependent metaplasticity of these inputs developed over the first five spikes in the train. Substance P induced significant activity-dependent depression of inhibitory but potentiation of excitatory interneuron inputs, whereas 5-HT induced significant activity-dependent potentiation of both inhibitory and excitatory interneuron inputs. Because these metaplastic effects are consistent with the substance P and 5-HT-induced modulation of the network output, activity-dependent metaplasticity could be a potential mechanism underlying the coordination and modulation of rhythmic network activity.  (+info)

even-skipped determines the dorsal growth of motor axons in Drosophila. (4/11810)

Axon pathfinding and target choice are governed by cell type-specific responses to external cues. Here, we show that in the Drosophila embryo, motorneurons with targets in the dorsal muscle field express the homeobox gene even-skipped and that this expression is necessary and sufficient to direct motor axons into the dorsal muscle field. Previously, it was shown that motorneurons projecting to ventral targets express the LIM homeobox gene islet, which is sufficient to direct axons to the ventral muscle field. Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field.  (+info)

Comparative effects of methylmercury on parallel-fiber and climbing-fiber responses of rat cerebellar slices. (5/11810)

The environmental neurotoxicant methylmercury (MeHg) causes profound disruption of cerebellar function. Previous studies have shown that acute exposure to MeHg impairs synaptic transmission in both the peripheral and central nervous systems. However, the effects of MeHg on cerebellar synaptic function have never been examined. In the present study, effects of acute exposure to MeHg on synaptic transmission between parallel fibers or climbing fibers and Purkinje cells were compared in 300- to 350-microm cerebellar slices by using extracellular and intracellular microelectrode-recording techniques. Field potentials of parallel-fiber volleys (PFVs) and the associated postsynaptic responses (PSRs) were recorded in the molecular layer by stimulating the parallel fibers in transverse cerebellar slices. The climbing-fiber responses were also recorded in the molecular layer by stimulating white matter in sagittal cerebellar slices. At 20, 100, and 500 microM, MeHg reduced the amplitude of both PFVs and the associated PSRs to complete block, however, it blocked PSRs more rapidly than PFVs. MeHg also decreased the amplitudes of climbing-fiber responses to complete block. For all responses, an initial increase in amplitude preceded MeHg-induced suppression. Intracellular recordings of excitatory postsynaptic potentials of Purkinje cells were compared before and after MeHg. At 100 microM and 20 microM, MeHg blocked the Na+-dependent, fast somatic spikes and Ca++-dependent, slow dendritic spike bursts. MeHg also hyperpolarized and then depolarized Purkinje cell membranes, suppressed current conduction from parallel fibers or climbing fibers to dendrites of Purkinje cells, and blocked synaptically activated local responses. MeHg switched the pattern of repetitive firing of Purkinje cells generated spontaneously or by depolarizing current injection at Purkinje cell soma from predominantly Na+-dependent, fast somatic spikes to predominantly Ca++-dependent, low amplitude, slow dendritic spike bursts. Thus, acute exposure to MeHg causes a complex pattern of effects on cerebellar synaptic transmission, with apparent actions on both neuronal excitability and chemical synaptic transmission.  (+info)

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. (6/11810)

The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and significant (P < 0.001) increase in the extracellular synaptic response by 23%. The induction of LTP was independent from activation of N-methyl-D-aspartate (NMDA) receptors, but prevented by bath application of NG-nitro-L-arginine methyl ester (L-NAME), indicating that one or several of the different NO synthases (NOS) produced NO within the postsynaptic neuron. No LTP could be induced in knockout mice lacking the endothelial NOS (eNOS) isoform. These data suggest that eNOS is involved in an NMDA receptor-independent form of LTP in the rodent cerebral cortex.  (+info)

Actions of a pair of identified cerebral-buccal interneurons (CBI-8/9) in Aplysia that contain the peptide myomodulin. (7/11810)

A combination of biocytin back-fills of the cerebral-buccal connectives and immunocytochemistry of the cerebral ganglion demonstrated that of the 13 bilateral pairs of cerebral-buccal interneurons in the cerebral ganglion, a subpopulation of 3 are immunopositive for the peptide myomodulin. The present paper describes the properties of two of these cells, which we have termed CBI-8 and CBI-9. CBI-8 and CBI-9 were found to be dye coupled and electrically coupled. The cells have virtually identical properties, and consequently we consider them to be "twin" pairs and refer to them as CBI-8/9. CBI-8/9 were identified by electrophysiological criteria and then labeled with dye. Labeled cells were found to be immunopositive for myomodulin, and, using high pressure liquid chromatography, the cells were shown to contain authentic myomodulin. CBI-8/9 were found to receive synaptic input after mechanical stimulation of the tentacles. They also received excitatory input from C-PR, a neuron involved in neck lengthening, and received a slow inhibitory input from CC5, a cell involved in neck shortening, suggesting that CBI-8/9 may be active during forward movements of the head or buccal mass. Firing of CBI-8 or CBI-9 resulted in the activation of a relatively small number of buccal neurons as evidenced by extracellular recordings from buccal nerves. Firing also produced local movements of the buccal mass, in particular a strong contraction of the I7 muscle, which mediates radula opening. CBI-8/9 were found to produce a slow depolarization and rhythmic activity of B48, the motor neuron for the I7 muscle. The data provide continuing evidence that the small population of cerebral buccal interneurons is composed of neurons that are highly diverse in their functional roles. CBI-8/9 may function as a type of premotor neuron, or perhaps as a peptidergic modulatory neuron, the functions of which are dependent on the coactivity of other neurons.  (+info)

Voltage-dependent properties of dendrites that eliminate location-dependent variability of synaptic input. (8/11810)

We examined the hypothesis that voltage-dependent properties of dendrites allow for the accurate transfer of synaptic information to the soma independent of synapse location. This hypothesis is motivated by experimental evidence that dendrites contain a complex array of voltage-gated channels. How these channels affect synaptic integration is unknown. One hypothesized role for dendritic voltage-gated channels is to counteract passive cable properties, rendering all synapses electrotonically equidistant from the soma. With dendrites modeled as passive cables, the effect a synapse exerts at the soma depends on dendritic location (referred to as location-dependent variability of the synaptic input). In this theoretical study we used a simplified three-compartment model of a neuron to determine the dendritic voltage-dependent properties required for accurate transfer of synaptic information to the soma independent of synapse location. A dendrite that eliminates location-dependent variability requires three components: 1) a steady-state, voltage-dependent inward current that together with the passive leak current provides a net outward current and a zero slope conductance at depolarized potentials, 2) a fast, transient, inward current that compensates for dendritic membrane capacitance, and 3) both alpha amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and N-methyl-D-aspartate-like synaptic conductances that together permit synapses to behave as ideal current sources. These components are consistent with the known properties of dendrites. In addition, these results indicate that a dendrite designed to eliminate location-dependent variability also actively back-propagates somatic action potentials.  (+info)

HIV (human immunodeficiency virus) infection is a condition in which the body is infected with HIV, a type of retrovirus that attacks the body's immune system. HIV infection can lead to AIDS (acquired immunodeficiency syndrome), a condition in which the immune system is severely damaged and the body is unable to fight off infections and diseases.

There are several ways that HIV can be transmitted, including:

1. Sexual contact with an infected person
2. Sharing of needles or other drug paraphernalia with an infected person
3. Mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Blood transfusions ( although this is rare in developed countries due to screening processes)
5. Organ transplantation (again, rare)

The symptoms of HIV infection can be mild at first and may not appear until several years after infection. These symptoms can include:

1. Fever
2. Fatigue
3. Swollen glands in the neck, armpits, and groin
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss

If left untreated, HIV infection can progress to AIDS, which is a life-threatening condition that can cause a wide range of symptoms, including:

1. Opportunistic infections (such as pneumocystis pneumonia)
2. Cancer (such as Kaposi's sarcoma)
3. Wasting syndrome
4. Neurological problems (such as dementia and seizures)

HIV infection is diagnosed through a combination of blood tests and physical examination. Treatment typically involves antiretroviral therapy (ART), which is a combination of medications that work together to suppress the virus and slow the progression of the disease.

Prevention methods for HIV infection include:

1. Safe sex practices, such as using condoms and dental dams
2. Avoiding sharing needles or other drug-injecting equipment
3. Avoiding mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Post-exposure prophylaxis (PEP), which is a short-term treatment that can prevent infection after potential exposure to the virus
5. Pre-exposure prophylaxis (PrEP), which is a daily medication that can prevent infection in people who are at high risk of being exposed to the virus.

It's important to note that HIV infection is manageable with proper treatment and care, and that people living with HIV can lead long and healthy lives. However, it's important to be aware of the risks and take steps to prevent transmission.

1. Group B streptococcus (GBS): This type of bacterial infection is the leading cause of infections in newborns. GBS can cause a range of complications, including pneumonia, meningitis, and sepsis.
2. Urinary tract infections (UTIs): These are common during pregnancy and can be caused by bacteria such as Escherichia coli (E. coli) or Staphylococcus saprophyticus. UTIs can lead to complications such as preterm labor and low birth weight.
3. HIV: Pregnant women who are infected with HIV can pass the virus to their baby during pregnancy, childbirth, or breastfeeding.
4. Toxoplasmosis: This is an infection caused by a parasite that can be transmitted to the fetus through the placenta. Toxoplasmosis can cause a range of complications, including birth defects and stillbirth.
5. Listeriosis: This is a rare infection caused by eating contaminated food, such as soft cheeses or hot dogs. Listeriosis can cause complications such as miscarriage, stillbirth, and premature labor.
6. Influenza: Pregnant women who contract the flu can be at higher risk for complications such as pneumonia and hospitalization.
7. Herpes simplex virus (HSV): This virus can cause complications such as preterm labor, low birth weight, and neonatal herpes.
8. Human parvovirus (HPV): This virus can cause complications such as preterm labor, low birth weight, and stillbirth.
9. Syphilis: This is a sexually transmitted infection that can be passed to the fetus during pregnancy, leading to complications such as stillbirth, premature birth, and congenital syphilis.
10. Chickenpox: Pregnant women who contract chickenpox can be at higher risk for complications such as preterm labor and low birth weight.

It's important to note that the risks associated with these infections are relatively low, and many pregnant women who contract them will have healthy pregnancies and healthy babies. However, it's still important to be aware of the risks and take steps to protect yourself and your baby.

Here are some ways to reduce your risk of infection during pregnancy:

1. Practice good hygiene: Wash your hands frequently, especially before preparing or eating food.
2. Avoid certain foods: Avoid consuming raw or undercooked meat, eggs, and dairy products, as well as unpasteurized juices and soft cheeses.
3. Get vaccinated: Get vaccinated against infections such as the flu and HPV.
4. Practice safe sex: Use condoms or other forms of barrier protection to prevent the spread of STIs.
5. Avoid close contact with people who are sick: If someone in your household is sick, try to avoid close contact with them if possible.
6. Keep your environment clean: Regularly clean and disinfect surfaces and objects that may be contaminated with germs.
7. Manage stress: High levels of stress can weaken your immune system and make you more susceptible to infection.
8. Get enough rest: Adequate sleep is essential for maintaining a healthy immune system.
9. Stay hydrated: Drink plenty of water throughout the day to help flush out harmful bacteria and viruses.
10. Consider taking prenatal vitamins: Prenatal vitamins can help support your immune system and overall health during pregnancy.

Remember, it's always better to be safe than sorry, so if you suspect that you may have been exposed to an infection or are experiencing symptoms of an infection during pregnancy, contact your healthcare provider right away. They can help determine the appropriate course of action and ensure that you and your baby stay healthy.

Zoonoses (zoonosis) refers to infectious diseases that can be transmitted between animals and humans. These diseases are caused by a variety of pathogens, including bacteria, viruses, parasites, and fungi, and can be spread through contact with infected animals or contaminated animal products.

Examples of Zoonoses

Some common examples of zoonoses include:

1. Rabies: a viral infection that can be transmitted to humans through the bite of an infected animal, typically dogs, bats, or raccoons.
2. Lyme disease: a bacterial infection caused by Borrelia burgdorferi, which is spread to humans through the bite of an infected blacklegged tick (Ixodes scapularis).
3. Toxoplasmosis: a parasitic infection caused by Toxoplasma gondii, which can be transmitted to humans through contact with contaminated cat feces or undercooked meat.
4. Leptospirosis: a bacterial infection caused by Leptospira interrogans, which is spread to humans through contact with contaminated water or soil.
5. Avian influenza (bird flu): a viral infection that can be transmitted to humans through contact with infected birds or contaminated surfaces.

Transmission of Zoonoses

Zoonoses can be transmitted to humans in a variety of ways, including:

1. Direct contact with infected animals or contaminated animal products.
2. Contact with contaminated soil, water, or other environmental sources.
3. Through vectors such as ticks, mosquitoes, and fleas.
4. By consuming contaminated food or water.
5. Through close contact with an infected person or animal.

Prevention of Zoonoses

Preventing the transmission of zoonoses requires a combination of personal protective measures, good hygiene practices, and careful handling of animals and animal products. Some strategies for preventing zoonoses include:

1. Washing hands frequently, especially after contact with animals or their waste.
2. Avoiding direct contact with wild animals and avoiding touching or feeding stray animals.
3. Cooking meat and eggs thoroughly to kill harmful bacteria.
4. Keeping pets up to date on vaccinations and preventative care.
5. Avoiding consumption of raw or undercooked meat, particularly poultry and pork.
6. Using insect repellents and wearing protective clothing when outdoors in areas where vectors are prevalent.
7. Implementing proper sanitation and hygiene practices in animal housing and husbandry.
8. Implementing strict biosecurity measures on farms and in animal facilities to prevent the spread of disease.
9. Providing education and training to individuals working with animals or in areas where zoonoses are prevalent.
10. Monitoring for and reporting cases of zoonotic disease to help track and control outbreaks.

Conclusion

Zoonoses are diseases that can be transmitted between animals and humans, posing a significant risk to human health and animal welfare. Understanding the causes, transmission, and prevention of zoonoses is essential for protecting both humans and animals from these diseases. By implementing appropriate measures such as avoiding contact with wild animals, cooking meat thoroughly, keeping pets up to date on vaccinations, and implementing proper sanitation and biosecurity practices, we can reduce the risk of zoonotic disease transmission and protect public health and animal welfare.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are several different types of malaria, including:

1. Plasmodium falciparum: This is the most severe form of malaria, and it can be fatal if left untreated. It is found in many parts of the world, including Africa, Asia, and Latin America.
2. Plasmodium vivax: This type of malaria is less severe than P. falciparum, but it can still cause serious complications if left untreated. It is found in many parts of the world, including Africa, Asia, and Latin America.
3. Plasmodium ovale: This type of malaria is similar to P. vivax, but it can cause more severe symptoms in some people. It is found primarily in West Africa.
4. Plasmodium malariae: This type of malaria is less common than the other three types, and it tends to cause milder symptoms. It is found primarily in parts of Africa and Asia.

The symptoms of malaria can vary depending on the type of parasite that is causing the infection, but they typically include:

1. Fever
2. Chills
3. Headache
4. Muscle and joint pain
5. Fatigue
6. Nausea and vomiting
7. Diarrhea
8. Anemia (low red blood cell count)

If malaria is not treated promptly, it can lead to more severe complications, such as:

1. Seizures
2. Coma
3. Respiratory failure
4. Kidney failure
5. Liver failure
6. Anemia (low red blood cell count)

Malaria is typically diagnosed through a combination of physical examination, medical history, and laboratory tests, such as blood smears or polymerase chain reaction (PCR) tests. Treatment for malaria typically involves the use of antimalarial drugs, such as chloroquine or artemisinin-based combination therapies. In severe cases, hospitalization may be necessary to manage complications and provide supportive care.

Prevention is an important aspect of managing malaria, and this can include:

1. Using insecticide-treated bed nets
2. Wearing protective clothing and applying insect repellent when outdoors
3. Eliminating standing water around homes and communities to reduce the number of mosquito breeding sites
4. Using indoor residual spraying (IRS) or insecticide-treated wall lining to kill mosquitoes
5. Implementing malaria control measures in areas where malaria is common, such as distribution of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS)
6. Improving access to healthcare services, particularly in rural and remote areas
7. Providing education and awareness about malaria prevention and control
8. Encouraging the use of preventive medications, such as intermittent preventive treatment (IPT) for pregnant women and children under the age of five.

Early diagnosis and prompt treatment are critical in preventing the progression of malaria and reducing the risk of complications and death. In areas where malaria is common, it is essential to have access to reliable diagnostic tools and effective antimalarial drugs.

There are many different types of epilepsy, each with its own unique set of symptoms and characteristics. Some common forms of epilepsy include:

1. Generalized Epilepsy: This type of epilepsy affects both sides of the brain and can cause a range of seizure types, including absence seizures, tonic-clonic seizures, and atypical absence seizures.
2. Focal Epilepsy: This type of epilepsy affects only one part of the brain and can cause seizures that are localized to that area. There are several subtypes of focal epilepsy, including partial seizures with complex symptoms and simple partial seizures.
3. Tonic-Clonic Epilepsy: This type of epilepsy is also known as grand mal seizures and can cause a loss of consciousness, convulsions, and muscle stiffness.
4. Lennox-Gastaut Syndrome: This is a rare and severe form of epilepsy that typically develops in early childhood and can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.
5. Dravet Syndrome: This is a rare genetic form of epilepsy that typically develops in infancy and can cause severe, frequent seizures.
6. Rubinstein-Taybi Syndrome: This is a rare genetic disorder that can cause intellectual disability, developmental delays, and various types of seizures.
7. Other forms of epilepsy include Absence Epilepsy, Myoclonic Epilepsy, and Atonic Epilepsy.

The symptoms of epilepsy can vary widely depending on the type of seizure disorder and the individual affected. Some common symptoms of epilepsy include:

1. Seizures: This is the most obvious symptom of epilepsy and can range from mild to severe.
2. Loss of consciousness: Some people with epilepsy may experience a loss of consciousness during a seizure, while others may remain aware of their surroundings.
3. Confusion and disorientation: After a seizure, some people with epilepsy may feel confused and disoriented.
4. Memory loss: Seizures can cause short-term or long-term memory loss.
5. Fatigue: Epilepsy can cause extreme fatigue, both during and after a seizure.
6. Emotional changes: Some people with epilepsy may experience emotional changes, such as anxiety, depression, or mood swings.
7. Cognitive changes: Epilepsy can affect cognitive function, including attention, memory, and learning.
8. Sleep disturbances: Some people with epilepsy may experience sleep disturbances, such as insomnia or sleepiness.
9. Physical symptoms: Depending on the type of seizure, people with epilepsy may experience physical symptoms such as muscle weakness, numbness or tingling, and sensory changes.
10. Social isolation: Epilepsy can cause social isolation due to fear of having a seizure in public or stigma associated with the condition.

It's important to note that not everyone with epilepsy will experience all of these symptoms, and some people may have different symptoms depending on the type of seizure they experience. Additionally, some people with epilepsy may experience additional symptoms not listed here.

Insects such as mosquitoes, wasps, bees, and hornets are common culprits of bites and stings that cause minor to severe reactions in humans. These reactions may cause pain, redness, swelling, itching, and burning sensations at the site of the bite or sting.

Most insect bites and stings can be treated with over-the-counter medications such as antihistamines, hydrocortisone creams, or calamine lotion. Severe allergic reactions may require medical attention and epinephrine injections to prevent anaphylaxis.

Types of NMJ Diseases:

1. Myasthenia Gravis (MG): An autoimmune disorder that causes muscle weakness and fatigue due to the immune system attacking the NMJs.
2. Lambert-Eaton Myasthenic Syndrome (LEMS): A rare autoimmune disorder that affects the NMJ and can cause muscle weakness, fatigue, and other symptoms.
3. Congenital Myasthenic Syndromes (CMS): A group of rare genetic disorders that affect the development and function of the NMJ, leading to muscle weakness and other symptoms.
4. Neuronal Ceroid Lipofuscinosis (NCL): A group of rare genetic disorders that affect the nervous system and can cause muscle weakness, seizures, and vision loss.
5. Inflammatory Myopathies: A group of muscle disorders caused by inflammation, such as polymyositis or dermatomyositis, which can affect the NMJ and cause muscle weakness.

Symptoms of NMJ Diseases:

1. Muscle weakness or paralysis
2. Fatigue and exhaustion
3. Difficulty swallowing or breathing (in severe cases)
4. Droopy eyelids or double vision
5. Slurred speech or difficulty speaking
6. Weakness in the arms and legs
7. Muscle wasting and loss of muscle mass
8. Seizures or fits
9. Vision loss or blurred vision
10. Cramps or spasms

Diagnosis of NMJ Diseases:

1. Medical history and physical examination
2. Electromyography (EMG) to test muscle activity and strength
3. Nerve conduction studies (NCS) to test nerve function
4. Imaging tests such as MRI or CT scans to rule out other conditions
5. Blood tests to check for autoantibodies or other signs of inflammation
6. Genetic testing to diagnose inherited forms of NMJ diseases

Treatment of NMJ Diseases:

1. Medications such as steroids, immunosuppressants, and anticonvulsants to reduce inflammation and muscle weakness
2. Physical therapy to improve muscle strength and function
3. Occupational therapy to improve daily living skills
4. Speech therapy to improve communication and swallowing difficulties
5. Surgery to relieve compression or repair damaged nerves or muscles
6. Plasmapheresis (plasma exchange) to remove harmful antibodies from the blood
7. Intravenous immunoglobulin (IVIG) therapy to reduce inflammation and modulate the immune system
8. Immunoadsorption therapy to remove antibodies from the blood and restore immune balance
9. Stem cell transplantation to replace damaged cells with healthy ones
10. Gene therapy to repair genetic defects causing NMJ diseases.

It's important to note that the treatment of NMJ diseases is highly individualized and may vary depending on the specific diagnosis, severity of symptoms, and overall health of the patient. A multidisciplinary approach involving neurologists, physical therapists, occupational therapists, speech therapists, and other specialists may be necessary to provide comprehensive care.

There are many different types of seizures, each with its own unique set of symptoms. Some common types of seizures include:

1. Generalized seizures: These seizures affect both sides of the brain and can cause a range of symptoms, including convulsions, loss of consciousness, and muscle stiffness.
2. Focal seizures: These seizures affect only one part of the brain and can cause more specific symptoms, such as weakness or numbness in a limb, or changes in sensation or vision.
3. Tonic-clonic seizures: These seizures are also known as grand mal seizures and can cause convulsions, loss of consciousness, and muscle stiffness.
4. Absence seizures: These seizures are also known as petit mal seizures and can cause a brief loss of consciousness or staring spell.
5. Myoclonic seizures: These seizures can cause sudden, brief muscle jerks or twitches.
6. Atonic seizures: These seizures can cause a sudden loss of muscle tone, which can lead to falls or drops.
7. Lennox-Gastaut syndrome: This is a rare and severe form of epilepsy that can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.

Seizures can be diagnosed through a combination of medical history, physical examination, and diagnostic tests such as electroencephalography (EEG) or imaging studies. Treatment for seizures usually involves anticonvulsant medications, but in some cases, surgery or other interventions may be necessary.

Overall, seizures are a complex and multifaceted symptom that can have a significant impact on an individual's quality of life. It is important to seek medical attention if you or someone you know is experiencing seizures, as early diagnosis and treatment can help to improve outcomes and reduce the risk of complications.

Falciparum malaria can cause a range of symptoms, including fever, chills, headache, muscle and joint pain, fatigue, nausea, and vomiting. In severe cases, the disease can lead to anemia, organ failure, and death.

Diagnosis of falciparum malaria typically involves a physical examination, medical history, and laboratory tests to detect the presence of parasites in the blood or other bodily fluids. Treatment usually involves the use of antimalarial drugs, such as artemisinin-based combination therapies (ACTs) or quinine, which can effectively cure the disease if administered promptly.

Prevention of falciparum malaria is critical to reducing the risk of infection, and this includes the use of insecticide-treated bed nets, indoor residual spraying (IRS), and preventive medications for travelers to high-risk areas. Eliminating standing water around homes and communities can also help reduce the number of mosquitoes and the spread of the disease.

In summary, falciparum malaria is a severe and life-threatening form of malaria caused by the Plasmodium falciparum parasite, which is responsible for the majority of malaria-related deaths worldwide. Prompt diagnosis and treatment are essential to prevent complications and death from this disease. Prevention measures include the use of bed nets, indoor spraying, and preventive medications, as well as reducing standing water around homes and communities.

There are several different types of pain, including:

1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.

The medical field uses a range of methods to assess and manage pain, including:

1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.

It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.

Brain hypoxia is a serious medical condition that requires prompt treatment to prevent long-term damage and improve outcomes for patients. Treatment options may include oxygen therapy, medications to improve blood flow to the brain, and surgery to remove any blockages or obstructions in blood vessels.

Examples of viral STDs include:

1. HIV (Human Immunodeficiency Virus): HIV attacks the body's immune system, making it harder to fight off infections and diseases. It can be spread through sex, sharing needles, or mother-to-child transmission during pregnancy, childbirth, or breastfeeding.
2. Herpes Simplex Virus (HSV): HSV causes genital herpes, which can cause painful blisters and sores on the genitals. It can be spread through skin-to-skin contact with an infected person.
3. Human Papillomavirus (HPV): HPV can cause genital warts, as well as cancer of the cervix, vulva, vagina, penis, or anus. It is usually spread through skin-to-skin contact with an infected person.
4. Hepatitis B Virus (HBV): HBV can cause liver disease and liver cancer. It is usually spread through sex, sharing needles, or mother-to-child transmission during childbirth.
5. Hepatitis C Virus (HCV): HCV can cause liver disease and liver cancer. It is usually spread through sex, sharing needles, or mother-to-child transmission during childbirth.

Preventing the spread of viral STDs includes:

1. Practicing safe sex, such as using condoms and dental dams.
2. Getting vaccinated against HPV and Hepatitis B.
3. Avoiding sharing needles or other drug paraphernalia.
4. Being in a mutually monogamous relationship with someone who has been tested and is negative for STDs.
5. Regularly getting tested for STDs, especially if you have a new sexual partner or engage in risky behavior.
6. Using condoms and other barrier methods consistently and correctly during all sexual activities.
7. Avoiding sexual contact with someone who has symptoms of an STD.
8. Being aware of your own sexual health status and the status of your partners, and being open and honest about your sexual history and any STDs you may have.
9. Seeking medical attention immediately if you suspect you or a partner has an STD.
10. Following safe sex practices and taking precautions to prevent the spread of STDs can help reduce the risk of developing these infections.

It's important to note that not all STDs have symptoms, so it's possible to have an STD and not know it. Regular testing is important for early detection and treatment, which can help prevent long-term health problems and the spread of infection.

In medicine, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure. This type of transmission can occur in various settings, such as hospitals, clinics, and long-term care facilities, where patients with compromised immune systems are more susceptible to infection.

Cross-infection can occur through a variety of means, including:

1. Person-to-person contact: Direct contact with an infected individual, such as touching, hugging, or shaking hands.
2. Contaminated surfaces and objects: Touching contaminated surfaces or objects that have been touched by an infected individual, such as doorknobs, furniture, or medical equipment.
3. Airborne transmission: Inhaling droplets or aerosolized particles that contain the infectious agent, such as during coughing or sneezing.
4. Contaminated food and water: Consuming food or drinks that have been handled by an infected individual or contaminated with the infectious agent.
5. Insect vectors: Mosquitoes, ticks, or other insects can transmit infections through their bites.

Cross-infection is a significant concern in healthcare settings, as it can lead to outbreaks of nosocomial infections (infections acquired in hospitals) and can spread rapidly among patients, healthcare workers, and visitors. To prevent cross-infection, healthcare providers use strict infection control measures, such as wearing personal protective equipment (PPE), thoroughly cleaning and disinfecting surfaces, and implementing isolation precautions for infected individuals.

In summary, cross-infection refers to the transmission of an infectious agent from one individual or source to another, often through direct contact or indirect exposure in healthcare settings. Preventing cross-infection is essential to maintaining a safe and healthy environment for patients, healthcare workers, and visitors.

1. Complete paralysis: When there is no movement or sensation in a particular area of the body.
2. Incomplete paralysis: When there is some movement or sensation in a particular area of the body.
3. Localized paralysis: When paralysis affects only a specific part of the body, such as a limb or a facial muscle.
4. Generalized paralysis: When paralysis affects multiple parts of the body.
5. Flaccid paralysis: When there is a loss of muscle tone and the affected limbs feel floppy.
6. Spastic paralysis: When there is an increase in muscle tone and the affected limbs feel stiff and rigid.
7. Paralysis due to nerve damage: This can be caused by injuries, diseases such as multiple sclerosis, or birth defects such as spina bifida.
8. Paralysis due to muscle damage: This can be caused by injuries, such as muscular dystrophy, or diseases such as muscular sarcopenia.
9. Paralysis due to brain damage: This can be caused by head injuries, stroke, or other conditions that affect the brain such as cerebral palsy.
10. Paralysis due to spinal cord injury: This can be caused by trauma, such as a car accident, or diseases such as polio.

Paralysis can have a significant impact on an individual's quality of life, affecting their ability to perform daily activities, work, and participate in social and recreational activities. Treatment options for paralysis depend on the underlying cause and may include physical therapy, medications, surgery, or assistive technologies such as wheelchairs or prosthetic devices.

The diagnosis of absence epilepsy is typically made based on a combination of clinical findings, including:
-A history of recurrent brief loss of awareness or staring spells
-Normal neurological examination between episodes
-Abnormal EEG activity during seizures (spikes or sharp waves)

Treatment for absence epilepsy usually involves medication, such as ethosuximide, valproic acid, or lamotrigine. In some cases, surgery may be considered if medications are ineffective or have significant side effects.

It is important to note that absence epilepsy can be a challenging condition to diagnose and treat, as the spells can be difficult to distinguish from other conditions such as daydreaming or attention deficit hyperactivity disorder (ADHD).

Symptoms of influenza include:

* Fever (usually high)
* Cough
* Sore throat
* Runny or stuffy nose
* Headache
* Muscle or body aches
* Fatigue (tiredness)
* Diarrhea and nausea (more common in children than adults)

Influenza can lead to serious complications, such as pneumonia, bronchitis, and sinus and ear infections. These complications are more likely to occur in people who have a weakened immune system, such as the elderly, young children, and people with certain chronic health conditions (like heart disease, diabetes, and lung disease).

Influenza is diagnosed based on a physical examination and medical history. A healthcare provider may also use a rapid influenza test (RIT) or a polymerase chain reaction (PCR) test to confirm the diagnosis.

Treatment for influenza typically involves rest, hydration, and over-the-counter medications such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) to relieve fever and body aches. Antiviral medications, such as oseltamivir (Tamiflu) or zanamivir (Relenza), may also be prescribed to help shorten the duration and severity of the illness. However, these medications are most effective when started within 48 hours of the onset of symptoms.

Prevention is key in avoiding influenza. Vaccination is the most effective way to prevent influenza, as well as practicing good hygiene such as washing your hands frequently, avoiding close contact with people who are sick, and staying home when you are sick.

In birds, the virus can cause respiratory, gastrointestinal, and nervous system disorders. It is transmitted through contact with infected birds or contaminated feces or water. Wild birds and domestic poultry are susceptible to influenza infection. The H5N1 subtype of the virus has caused widespread outbreaks in poultry and wild birds, leading to significant economic losses and public health concerns.

Prevention methods include vaccination, biosecurity measures, and surveillance programs. Vaccines are available for chickens, turkeys, ducks, and other domesticated birds, but the effectiveness of these vaccines can be limited in protecting against certain subtypes of the virus. Biosecurity measures such as sanitation, isolation, and disinfection can help prevent the spread of the disease in poultry flocks. Surveillance programs monitor the presence of the virus in wild and domestic bird populations to detect outbreaks early and prevent the spread of the disease.

The impact of avian influenza on human health is generally minimal, but it can be severe in certain cases. Direct transmission of the virus from birds to humans is rare, but it can occur through close contact with infected birds or contaminated surfaces. Indirect transmission may occur through the handling of contaminated poultry products. People with weakened immune systems, such as young children, the elderly, and those with chronic diseases, are at a higher risk of developing severe symptoms from avian influenza.

Overall, avian influenza is an important disease in birds that can have significant economic and public health implications. Prevention and control measures are essential to minimize the impact of the disease on both bird populations and human health.

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This was in contrast to the reserve pool of synaptic vesicles that was not yet involved in the transmission process. The data ... Zimmermann, H. (1993) Synaptic Transmission. Cellular and Molecular Basis. Thieme/Oxford, University Press, ISBN 0-19-521065-4 ... suggested that synaptic activation induces synaptic vesicle heterogeneity whereby reloaded synaptic vesicles preferentially ... In Cambridge, in the laboratory of Victor P. Whittaker, he began his studies on the dynamics of the synaptic vesicle ...
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Nonsynaptic junctional transmission is the only mode of transmission involving the varicosities that show no synaptic contacts ... Non-synaptic transmission is characteristic of autonomic neuroeffector junctions. The essential features are that: the terminal ... Non-synaptic transmission is characteristic of autonomic neuroeffector junctions. The structure of the autonomic neuromuscular ... The "close" junctional transmission is associated with fast junction potential and the "wide" junctional transmission is ...
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Studies by Donald Faber and Henri Korn helped to establish the one vesicle hypothesis of synaptic transmission in the CNS. ... The M-cell system has served for detailed neurophysiological and histological investigations of synaptic transmission and ... "Long-term potentiation of glycinergic inhibitory synaptic transmission". J. Neurophysiol. 74 (3): 1056-74. doi:10.1152/jn. ... Pereda AE, Rash JE, Nagy JI, Bennett MV (December 2004). "Dynamics of electrical transmission at club endings on the Mauthner ...
... altering glutamatergic synaptic transmission. AMPA receptor localization is important for synaptic plasticity, because ... However, overall synaptic transmission is not profoundly affected. Current knowledge suggests that alteration in VPS35 levels ... Brodin L, Shupliakov O (2018). "Retromer in Synaptic Function and Pathology". Frontiers in Synaptic Neuroscience. 10: 37. doi: ... These changes result in the degeneration of neurons, leading to a loss of synaptic connections and neurotransmitter signaling. ...
Eccles had made important discoveries on synaptic transmission. Huxley was elected a Fellow of the Royal Society (FRS) in 1955 ... Hodgkin was interested in the transmission of electrical signals along nerve fibres. Beginning in 1935 in Cambridge, he had ...
They also uncovered the mechanism underlying inhibitory synaptic transmission. In a series of seminal papers in the early 1970s ... Katz's biophysics laboratory and it was here that he developed his interest in the molecular aspects of synaptic transmission. ... To achieve this, they developed a voltage-clamp technique to demonstrate that impulse transmission relied upon the selective ... in 1904 and went on to share the 1936 Nobel Prize for Medicine for their seminal investigation on the chemical transmission of ...
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Increased levels of SNAP-25b have been shown to impair synaptic transmission and maturation which could lead to early-onset ... Ilardi JM, Mochida S, Sheng ZH (February 1999). "Snapin: a SNARE-associated protein implicated in synaptic transmission". ... Ilardi JM, Mochida S, Sheng ZH (February 1999). "Snapin: a SNARE-associated protein implicated in synaptic transmission". ... "Transgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutant". Brain Research. 847 (2 ...
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NMDARs trigger both long-term potentiation (LTP) and long-term depression (LTD) via fast synaptic transmission. Experimental ... February 2005). "Long-term changes in glutamatergic synaptic transmission in phenylketonuria". Brain. 128 (Pt 2): 300-307. doi: ... Experiments have been designed to stimulate either synaptic or non-synaptic NMDA receptors exclusively. These types of ... CDK5 regulates the amount of NR2B-containing NMDA receptors on the synaptic membrane, thus affecting synaptic plasticity. ...
Epigenetic mechanisms as a result of early life stress may be responsible for neuronal and synaptic alterations in the brain. ... Yahyavi ST, Zarghami M, Marwah U (2013). "A review on the evidence of transgenerational transmission of posttraumatic stress ... Transgenerational stress inheritance is the transmission of adverse effects of stress-exposure in parents to their offspring ... Kellermann NP (2013). "Epigenetic transmission of Holocaust trauma: can nightmares be inherited?". review. The Israel Journal ...
By recruiting the receptors and viral particles at the point of contact, these synaptic structures significantly enhance the ... "Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells". Cell Rep. ... cell to allow cell-to-cell transmission. As viral synapses allow the virus to spread directly from cell to cell, they also ... "Polarized Cell Migration during Cell-to-Cell Transmission of Herpes Simplex Virus in Human Skin Keratinocytes". J. Virol. 87 ( ...
... which has a significant effect on electrical conduction along an axon as well as synaptic transmission. Potassium channels ... They also play a role in neurotransmitter release in pre-synaptic nerve endings. In most cells, Ca2+ channels regulate a wide ...
A decrease in synaptic transmission is also seen with hypoxia. There are several inward currents that are proposed to help ... This is due to the reduction of excitatory synaptic transmission in a nucleus and increased excitability in motor neurons ... The respiratory system is regulated by multiple forms of long-term synaptic plasticity. The role of synaptic inhibition has ... which allows for active expiration to be produced by synaptic inhibition within the respiratory network. Synaptic inhibition is ...
Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion ... as blocking this protein replicated the effect of nerve injury and reduced the threshold for transmission of painful stimuli, a ... Bories C, Husson Z, Guitton MJ, De Koninck Y. Differential balance of prefrontal synaptic activity in successful versus ...
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They participate in long term potentiation and long term depression, and they are removed from the synaptic membrane in ... "Presynaptic inhibitory action of metabotropic glutamate receptor agonist on excitatory transmission in visual cortical neurons ... Like other glutamate receptors, mGluRs have been shown to be involved in synaptic plasticity and in neurotoxicity and ... Archived 2007-09-15 at the Wayback Machine, University of Bristol Centre for Synaptic Plasticity (2003). Retrieved January 20, ...
... controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2". The Journal of Neuroscience. 32 (16): ...
Metabotropic glutamate autoreceptor activation in these neurons may inhibit synaptic transmission by inhibiting calcium influx ... Synaptic fatigue, or short-term synaptic depression, is an activity-dependent form of short term synaptic plasticity that ... Synaptic fatigue can affect many synapses of many different types of neurons. The existence and observations of synaptic ... synaptic fatigue is not a result of Ca2+ ions building up in the terminal, and most importantly that synaptic fatigue is an ...
There is some experimental evidence that RSK2 regulates synaptic transmission and plasticity in neuronal cell types. Affected ...
The cells of different subtypes also differ in their dendritic structure and synaptic targets in the brain. The neurons that ... An acetylcholine (ACh) transmission model of directionally selective starburst amacrine cells provides a robust topological ... Zhou ZJ, Lee S (September 2008). "Synaptic physiology of direction selectivity in the retina". The Journal of Physiology. 586 ( ... Carver S, Roth E, Cowan NJ, Fortune ES (February 2008). "Synaptic plasticity can produce and enhance direction selectivity". ...
"Data Transmission : EXTREME SUB-GENRE [sic] TOP 10". Archived from the original on September 21, 2010. "Minimal Drum and Bass ... Major labels include Inperspective and Synaptic Plastic and the new wave of artists in this style include ASC, Fanu, Breakage, ...
Shepherd, Gordon M. (2004). "1. Introduction to synaptic circuits". The Synaptic Organization of the Brain (5th ed.). Oxford ... ISBN 978-0-262-54185-5. Averbeck, BB; Lee, D (2004). "Coding and transmission of information by neural ensembles". Trends in ... The synaptic network that finally emerges is only partly determined by genes, though. In many parts of the brain, axons ... A single axon may make as many as several thousand synaptic connections with other cells. When an action potential, traveling ...
GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration ... of GlyT2 in knockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission ... Rousseau F, Aubrey KR, Supplisson S (2008). "The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling ... Therefore, chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic ...
Gilbert ME (January 2004). "Alterations in synaptic transmission and plasticity in area CA1 of adult hippocampus following ... When mice were created with this single, conservative amino acid substitution in TRβ, synaptic maturation and plasticity in the ...
The neuronal cells have the calcium-signaling microdomains in the cytoplasm right next to the pre- and post-synaptic calcium ... Lisman, J. E.; Raghavachari, S.; Tsien, R. W. (2007). "The sequence of events that underlie quantal transmission at central ... Francis, A. A.; Mehta, B.; Zenisek, D. (2011). "Development of new peptide-based tools for studying synaptic ribbon function". ...
"Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine". Neuron. 49 ( ... "Food-elicited increases in cortical acetylcholine release require orexin transmission". Neuroscience. 149 (3): 499-507. doi: ...
The final aim of these studies is a detailed molecular understanding of synaptogenesis and synaptic transmission, which in turn ... will be useful for the design of therapeutic strategies for neurological and psychiatric diseases that involve synaptic ...
The human cerebral cortex alone contains on the order of 1010 neurons linked by 1014 synaptic connections. By comparison, the ... "Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy". Cell. 184 (3): ... Microscale rewiring is the formation or removal of synaptic connections between two neurons and can be studied with ... and fusion of barcodes to represent a synaptic pair. This approach has the potential to be cheap, fast, and extremely high- ...
Alcohol's ability to alter behavior and decision-making stems from its impact on synaptic transmission at GABA receptors. ... Alcohol's effects on the synaptic level dampen the brain's processing ability and limit attentional capacity. Overall, the ...
June 2007). "Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain ... a wireless transmission module, and a Bluetooth enabled cell phone. The electrodes were placed so that they pick up steady ... stimulation to restore functional connectively and associated behaviors through modulation of molecular mechanisms of synaptic ...
"Quantum Mechanical Tunneling in Synaptic and Ephaptic Transmission, Int. J. Quantum Chemistry 11, 103-127, 1977. "The Compleat ...
Knockout studies in Drosophila show that reduced expression of dysbindin reduced glutamatergic synaptic transmission, resulting ... C4A was found to play a role in synaptic pruning, and increased C4A expression leads to reduced dendritic spines and a higher ... Mukaetova-Ladinska EB, Hurt J, Honer WG, Harrington CR, Wischik CM (2002). "Loss of synaptic but not cytoskeletal proteins in ... those of the neuregulin post-synaptic receptor. The result showed that although the mice mostly developed normally, on further ...
... involves a specific signal transmission process that underlies synaptic plasticity. Among the many mechanisms responsible for ... serve as a link between synaptic activity and synaptic plasticity, and play important roles in the processes of learning and ... The deletion of β-catenin in vivo results in a decrease in the number of RPVs localized in the synaptic site and an increase in ... At basal levels of synaptic activity, N-cadherins are largely monomers and are thus weakly adhesive to cadherins located in the ...
The change in potential causes the accuracy of a neuron to be limited in its transmission. This limited transmission has been ... Synaptic noise refers to the constant bombardment of synaptic activity in neurons. This occurs in the background of a cell when ... From notable research by Stacey and Durand, synaptic noise has been credited for enhanced detection of weak or distal synaptic ... A computational model of synaptic noise is created and is then implemented into the neuron, simulating synaptic noise. This can ...
Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A (May 1995). "Amphetamine redistributes dopamine from synaptic ... van Kammen DP, Antelman S (April 1984). "Impaired noradrenergic transmission in schizophrenia?". Life Sciences. 34 (15): 1403- ... serotonin and norepinephrine to build up in the synaptic cleft. The potential for cocaine addiction is thought to be a result ... The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with ...
"Biochemical plasticity of synaptic transmission: A critical review of Dale's Principle". Biological Psychiatry. 11 (4): 481-524 ...
... J Am Soc Nephrol. 2009 Sep;20(9):1862-4. doi: 10.1681/ASN. ...
What is Synaptic Transmission? (01:58). FREE PREVIEW Have you got the nerve to explore synaptic transmission? ... What is Synaptic Transmission?. Part of the Series : Biology DVD (Chaptered) Price: $99.95 Add to Cart *Add to Cart ...
All the latest news about synaptic transmission from Medical Xpress ... They have successfully recorded synaptic transmission between neurons in a live animal for the first time. ... Optogenetics captures neuronal transmission in live mammalian brain. Swiss scientists have used a cutting-edge method to ... Each takes the baton from an incoming action potential and passes the neural message across the synaptic divide, yet each ...
Synaptic Transmission at the Ribbon Synapses of the Eye and Ear ... Synaptic Transmission at the Ribbon Synapses of the Eye and Ear ... A key event in synaptic transmission is the release of neurotransmitter via vesicle fusion at synaptic terminals. Direct ... A key event in synaptic transmission is the release of neurotransmitter via vesicle fusion at synaptic terminals. Direct ... Synaptic transmission at the ribbon synapses of the eye and ear / Henrique von Gersdorff. ...
... protean neuromodulators of synaptic transmission in mammalian brain Prog Neurobiol 2006 79(5-6):223-46 ... "The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain". ... protean neuromodulators of synaptic transmission in mammalian brain" Prog Neurobiol. 2006 Aug 29;79(5-6):223-46. ... have revitalized the field of scientific studies investigating trace amine synaptic physiology, and its association with major ...
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity Collin J Kreple 1 , Yuan Lu ... Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity Collin J Kreple et al. Nat ... Role of ASIC1a in Normal and Pathological Synaptic Plasticity. Mango D, Nisticò R. Mango D, et al. Rev Physiol Biochem ... Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations. Gupta SC, Taugher-Hebl RJ, Hardie JB, ...
Inhibition of all synaptic transmission with EDTA (D) or inhibition of glutamatergic AMPA/kainate receptor signaling with CNQX ... Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn. Heles M, ... Morphine-sensitive synaptic transmission emerges in embryonic rat microphysiological model of lower afferent nociceptive ... Morphine-sensitive synaptic transmission emerges in embryonic rat microphysiological model of lower afferent nociceptive ...
Effect Of Heat Pretreatment On Spontaneous Glutamatergic And Glycinergic Synaptic Transmission During Subsequent Thermal Stress ... Effect Of Heat Pretreatment On Spontaneous Glutamatergic And Glycinergic Synaptic Transmission During Subsequent Thermal Stress ... stroke induces an acclimatory response opposing extreme deviation from normal frequencies of spontaneous synaptic transmission ... determine whether thermal pretreatment alters the frequency of spontaneous glutamatergic and glycinergic synaptic transmission ...
... retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission. Cell ... Current reports of synaptic actions of eCBs in the LHb are conflicting and lack systematic investigation of eCB regulation of ... Current reports of synaptic actions of eCBs in the LHb are conflicting and lack systematic investigation of eCB regulation of ... Current reports of synaptic actions of eCBs in the LHb are conflicting and lack systematic investigation of eCB regulation of ...
Interneurons and Synaptic Transmission. At the time of establishing my lab in 1993 there was little known concerning glutamate ... Mechanisms of Mossy Fiber Synaptic Transmission. A major focus of the lab for almost a decade was the exploration of the ... We have shown novel forms of synaptic transmission as well as distinct mechanisms of both short- and long term plasticity of ... inhibition balance remained fixed onto downstream CA3 principal neuron targets despite many features of synaptic transmission ...
SA supplementation enhanced synaptic transmission mainly by altering the kinetics of synaptic transmission. CONCLUSIONS:. The ... Besides, electrophysiological results revealed SA enhanced synaptic transmission rather than neuronal excitability of mPFC ... Sialic Acid Enhanced the Antistress Capability under Challenging Situations by Increasing Synaptic Transmission. ... and the enhanced synaptic transmission of mPFC excitatory neurons may be the neurological basis of active response under ...
Start Over You searched for: Subjects Synaptic Transmission ✖Remove constraint Subjects: Synaptic Transmission ... Synaptic Transmission Archival Collection: The Marshall W. Nirenberg Papers (Profiles in Science) 3. Mechanisms of synaptic ... Synaptic Vesicles -- physiology. Synaptic Transmission. Functional Neuroimaging. Fluorescent Dyes 2. Neurotransmitter Synthesis ...
... Hot Off the Press - ... Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers Journal Article ... title = {Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers},. author = { ... Anatomical studies suggest that cholinergic terminals signal predominantly through non-synaptic volume transmission. However, ...
The resting membrane potential of larval Drosophila muscle and synaptic transmission at the neuromuscular junction are pH ... The present study investigated the effects of doxapram on membrane potential and synaptic transmission using intracellular ... The resting membrane potential of larval Drosophila muscle and synaptic transmission at the neuromuscular junction are pH ... The resting membrane potential of larval Drosophila muscle and synaptic transmission at the neuromuscular junction are pH ...
... BIBLIOGRAPHIC ... and the highly specific calpain inhibitor BDA-410 restored normal synaptic function both in hippocampal cultures and in ... with restoration of normal phosphorylation levels of the transcription factor CREB and involved redistribution of the synaptic ...
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 2017 Sep 27;96(1):73-80.e4. doi ... Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. In: Neuron. 2017 ; Vol. 96, No. 1. pp. ... Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Hsin Wei Lu, Timothy S. Balmer, Gabriel ... Lu, H. W., Balmer, T. S., Romero, G. E., & Trussell, L. O. (2017). Slow AMPAR Synaptic Transmission Is Determined by Stargazin ...
As a consequence, both synaptic transmission and LTP in CA1 are facilitated and action potential firing is altered. In contrast ... Using extra- and intracellular techniques, synaptic transmission, long-term potentiation (LTP) and vulnerability to pro- ... synaptic transmission, long-term potentiation (LTP) and vulnerability to pro-epileptic conditions were analyzed. Results: We ... Figure 2. Synaptic transmission is altered in CA1, but not the dentate gyrus. (A) Input-output relationships of dentate gyrus ( ...
1995) Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I- ... Synapsin is the most abundant synaptic phosphoprotein that reversibly attaches to synaptic vesicles and regulates synaptic ... 2009) Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell 139:393-404, doi:10.1016/j.cell.2009.07. ... 1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259:780-785, doi:10.1126/science.8430330, ...
synaptic transmission. GenBank: AAD11417.1. Interleukin-9. 144. cytokine. GenBank: AAH66284.1. interleukin-18. 189. Increased ...
Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse ... Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse ... Chemogenetic synaptic silencing of neural circuits localizes a Hypothalamus→Midbrain pathway for feeding behavior. Neuron 2014; ... Synaptic mechanisms underlying strong reciprocal connectivity between the medial prefrontal cortex and basolateral amygdala. J ...
... basic research on synaptic transmission and plasticity.. Acquired epilepsies (with focus on epilepsies with immunological or ... Huntingtons Disease; Spinocerebellar Ataxias (SCAs); invertebrate neuromuscular junction synaptic development, structure, and ... basic research on synaptic function; tripartite synapse.. Molecular structure, function, and regulation of ion channels, ...
Endocannabinoid-mediated retrograde signaling is a fundamental counterpart of anterograde synaptic transmission throughout the ... Endocannabinoids and Synaptic Plasticity in Homeostasis Discussion Leader: Bradley Alger (University of Maryland, Baltimore, ... Keynote Session: Endocannabinoid Signaling and the Synaptic Nanoarchitecture Discussion Leader: Ken Mackie (Indiana University ... synaptic and circuit levels has remained rather limited. Moreover, in the age of rapidly spreading medical and recreational use ...
Neuronal cell biology and synaptic transmission: driskill graduate enter in existence sciences: feinberg med school: ... Synaptic homeostasis: flies rodents and humans -… by Alex June 29, 2021 We used the effective forward genetics of Drosophila to ... 8. Searl TJ & Silinsky EM (2012) Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is separate from ... Timothy Searl, Research Assistant Professor, studies neuromuscular transmission and it is modulation at both voluntary ( ...
Impaired ca2+ sensitivity of a novel gcap1 variant causes cone dystrophy and leads to abnormal synaptic transmission between ... its implication in synaptic transmission to downstream neurons remains to be clarified. Here, we present clinical and ... its implication in synaptic transmission to downstream neurons remains to be clarified. Here, we present clinical and ... Impaired ca2+ sensitivity of a novel gcap1 variant causes cone dystrophy and leads to abnormal synaptic transmission between ...
Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard ... Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard ...
... synaptic transmission) and are therefore under precise temporal control. Dysfunctions in synaptic transmission contribute to ...
Weiszs laboratory investigates the synaptic transmission and electrical properties of descending neuronal circuitry in the ... Her graduate work involved studies of synaptic inputs and electrical properties of cochlear type II spiral ganglion afferent ...
  • They have successfully recorded synaptic transmission between neurons in a live animal for the first time. (medicalxpress.com)
  • As part of our investigation into the effects of hyperthermia on neuronal function, we used standard whole-cell patch clamp techniques to determine whether thermal pretreatment alters the frequency of spontaneous glutamatergic and glycinergic synaptic transmission between neurons of the mouse pre-B�tzinger complex during subsequent hyperthermia. (sicb.org)
  • Besides, electrophysiological results revealed SA enhanced synaptic transmission rather than neuronal excitability of mPFC excitatory neurons . (bvsalud.org)
  • The SA supplementation enhanced the response capability to stress under challenging situations, and the enhanced synaptic transmission of mPFC excitatory neurons may be the neurological basis of active response under challenging situations. (bvsalud.org)
  • With this chapter, we begin to consider the signaling between neurons through the process of synaptic transmission. (mhmedical.com)
  • Whereas the Purkinje cell of the cerebellum receives up to 100,000 synaptic inputs, the neighboring granule neurons, the most numerous class of neurons in the brain, receive only around four excitatory inputs. (mhmedical.com)
  • Although many of the synaptic connections in the central and peripheral nervous systems are highly specialized, all neurons make use of one of the two basic forms of synaptic transmission: electrical or chemical. (mhmedical.com)
  • Recently, we reported that the mesolimbic dopaminergic system was tonically suppressed during chronic pain by enhanced inhibitory synaptic inputs to neurons projecting from the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA), suggesting that tonic suppression of the mesolimbic dopaminergic system by this neuroplastic change may be involved in chronic pain-induced depression-like behaviors. (biomedcentral.com)
  • In this study, we hypothesized that inhibitory synaptic inputs to VTA-projecting dlBNST neurons are also enhanced in animal models of depression, thereby suppressing the mesolimbic dopaminergic system. (biomedcentral.com)
  • The findings revealed enhanced inhibitory synaptic inputs to VTA-projecting dlBNST neurons in this rat model of depression, suggesting that this neuroplastic change is a neuronal mechanism common to depression and chronic pain that causes dysfunction of the mesolimbic dopaminergic system, thereby inducing depression-like behaviors. (biomedcentral.com)
  • Thus, enhanced inhibitory synaptic inputs to VTA-projecting dlBNST neurons should activate VTA GABAergic neurons via a disinhibition mechanism, thereby causing suppression of VTA dopaminergic neurons that may induce depression and anhedonia observed in animal models of chronic pain. (biomedcentral.com)
  • Although very close, the neurons do not actually touch each other, but are separated by the synaptic cleft that allows chemical messages to pass across from one neuron to the receptors of another neuron on the other side. (anat.org.au)
  • Patterned depolarization of Drosophila motor neurons can rapidly induce the outgrowth of new synaptic boutons at the larval neuromuscular junction (NMJ), providing a model system to investigate mechanisms underlying acute structural plasticity. (jneurosci.org)
  • Her graduate work involved studies of synaptic inputs and electrical properties of cochlear type II spiral ganglion afferent neurons in the laboratories of Dr. Paul Fuchs and Dr. Elisabeth Glowatzki. (nih.gov)
  • While the phototransduction-associated role of GCAP1 in the photoreceptor outer segment is widely established, its implication in synaptic transmission to downstream neurons remains to be clarified. (unicatt.it)
  • They are presently investigating mechanisms for short-term synaptic plasticity at reciprocal synapses in retinal slices, and multivesicular release at the hair cell synapse using capacitance measurements together with paired recordings of hair cells and their afferent fibers. (nih.gov)
  • These differences range from the molecular identity of receptors and channels to mechanisms of short- and long-term synaptic plasticity and signal transduction mechanisms associated with glutamate receptors. (nih.gov)
  • We have shown novel forms of synaptic transmission as well as distinct mechanisms of both short- and long term plasticity of synaptic transmission. (nih.gov)
  • This synaptic plasticity is crucial for memory and for other higher brain functions. (mhmedical.com)
  • basic research on synaptic transmission and plasticity. (nih.gov)
  • To characterize the presynaptic mechanisms mediating new synaptic growth induced by patterned activity, we investigated the formation of new boutons in NMJs lacking synapsin [Syn(−)], a synaptic protein important for vesicle clustering, neurodevelopment, and plasticity. (jneurosci.org)
  • Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard nonmotor tasks. (nin.nl)
  • Our genetic results indicate that at glycinergic synapses, the glial transporter GlyT1 catalyses the removal of glycine from the synaptic cleft, whereas GlyT2 is required for the re-uptake of glycine into nerve terminals, thereby allowing for neurotransmitter reloading of synaptic vesicles. (nih.gov)
  • In response to the presynaptic neuron being excited by electrical signals, known as action potentials , the vesicles release the neurotransmitters into the synaptic cleft, where they bond with the receptors in a fluid medium. (anat.org.au)
  • Desensitization has been studied traditionally with prolonged agonist exposure, whereas the duration of free neurotransmitter in the synaptic cleft is relatively brief. (elsevierpure.com)
  • However, the space between the two nerve cells at at synapse, called the synaptic cleft, is no more than 40 nanometers wide. (elifesciences.org)
  • Though the probe must be small enough to pass through the synaptic cleft to do this. (elifesciences.org)
  • have now developed a quantum dot that is only 10 nanometers wide and therefore small enough to enter the synaptic cleft with an AMPA receptor attached. (elifesciences.org)
  • Current reports of synaptic actions of eCBs in the LHb are conflicting and lack systematic investigation of eCB regulation of excitatory and inhibitory transmission. (northwestern.edu)
  • Work in the McBain Laboratory is targeted towards understanding the development of excitatory and inhibitory synaptic transmission between specific identified neural populations within the hippocampal and cortical formations. (nih.gov)
  • it remains unknown how new synaptic boutons differentiate and mature and what presynaptic mechanisms mediate their growth. (jneurosci.org)
  • In conclusion, the pathological phenotype may rise from a combination of second messengers' accumulation and dysfunctional synaptic communication with bipolar cells, whose molecular mechanisms remain to be clarified. (unicatt.it)
  • However, a 15 min thermal pretreatment at 39.5˚ - 41˚C one hour prior to such hyperthermia significantly reduced the increase in frequency of spontaneous transmission via glutamate to 456.5 � 43.4% above 30˚C baseline (p (sicb.org)
  • Here, we report that eCBs differentially regulate glutamatergic and GABAergic transmission in the LHb, exhibiting canonical and circuit-specific inhibition of both systems and an opposing potentiation of synaptic glutamate release mediated via activation of CB 1 receptors on astrocytes. (northwestern.edu)
  • Studies of acetylcholine-, glutamate- and GABA-gated channels using rapid agonist application now provide a means to assess the effects of desensitization in shaping synaptic responses and in influencing neuronal excitability. (elsevierpure.com)
  • Using extra- and intracellular techniques, synaptic transmission, long-term potentiation (LTP) and vulnerability to pro-epileptic conditions were analyzed. (frontiersin.org)
  • Using electrophysiological, immunohistochemical, anatomical, molecular and genetic approaches we hope to gain significant insight into the developmental- and activity-dependent regulation of cellular and synaptic efficacy under both physiological and pathophysiological conditions. (nih.gov)
  • Unlike mature boutons, new varicosities have synaptic vesicles which are distributed uniformly throughout the bouton and undeveloped postsynaptic specializations. (jneurosci.org)
  • A key event in synaptic transmission is the release of neurotransmitter via vesicle fusion at synaptic terminals. (nih.gov)
  • This direct access to the terminal allows the lab to study the kinetics of synaptic vesicle exocytosis and endocytosis, neurotransmitter reuptake, and the modulation of neuronal output patterns by presynaptic receptors and the Na+/K+-ATPase pump. (nih.gov)
  • While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. (erowid.org)
  • Transmission from striatal cholinergic interneurons (CINs) controls dopamine release through nicotinic acetylcholine receptors (nAChRs) on dopaminergic axons. (nih.gov)
  • The average neuron forms several thousand synaptic connections and receives a similar number of inputs. (mhmedical.com)
  • However, using high time resolution patch-clamp and membrane capacitance measurements, Dr. Von Gersdorff Lab has studied the kinetics of vesicle fusion (exocytosis) and subsequent membrane retrieval (endocytosis) in single, live synaptic terminals from bipolar cells of the goldfish retina and from hair cells of the frog amphibian papilla. (nih.gov)
  • Following short depolarizations, a fast form of endocytosis can be observed, indicating that synaptic vesicle membrane is quickly re-internalized after vesicle fusion. (nih.gov)
  • We found that budding of new boutons at Syn(−) NMJs was significantly diminished, and that new boutons in Syn(−) preparations were smaller and had reduced synaptic vesicle density. (jneurosci.org)
  • The resting membrane potential of larval Drosophila muscle and synaptic transmission at the neuromuscular junction are pH sensitive. (eku.edu)
  • Dr. Silinsky, aided by his collaborator and laboratory co-director Dr. Timothy Searl, Research Assistant Professor, studies neuromuscular transmission and it is modulation at both voluntary (skeletal) and involuntary (autonomic) neuromuscular junctions. (futureiplabs.info)
  • The present study investigated the effects of doxapram on membrane potential and synaptic transmission using intracellular recordings of larval Drosophila muscles. (eku.edu)
  • Furthermore, SA supplementation enhanced synaptic transmission mainly by altering the kinetics of synaptic transmission . (bvsalud.org)
  • However, despite decades of dedicated research, our understanding of the governing principles of endocannabinoid signaling at the molecular, synaptic and circuit levels has remained rather limited. (grc.org)
  • 13. GABAergic synaptic transmission. (nih.gov)
  • However, this has yet to be confirmed directly, in part because conventional fluorescent dyes and quantum dots are too bulky to enter synaptic clefts when bound to a receptor. (elifesciences.org)
  • However, the influence of cholinergic transmission on electrical signaling in axons remains unclear. (nih.gov)
  • Thus, we reveal that synaptic-like neurotransmission underlies cholinergic signaling onto dopaminergic axons, supporting the idea that striatal dopamine release can occur independently of somatic firing to provide distinct signaling. (nih.gov)
  • Endocannabinoid-mediated retrograde signaling is a fundamental counterpart of anterograde synaptic transmission throughout the CNS. (grc.org)
  • Why there are different types of endocannabinoids and what is the division of labor between these lipid messengers in synaptic and extrasynaptic signaling? (grc.org)
  • Neuronal networks modify their activity in response to stimulation, and short-term changes in synaptic efficacy can lead to morphological changes in synaptic ultrastructure. (jneurosci.org)
  • Because chemical synaptic transmission is so central to understanding brain and behavior, it is examined in detail in the next four chapters. (mhmedical.com)
  • Synaptic transmission is fundamental to the neural functions we consider in this book, such as perception, voluntary movement, and learning. (mhmedical.com)
  • A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. (erowid.org)
  • GlyT2 is highly enriched at glycinergic nerve terminals, and Ca(2+)-triggered exocytosis and internalization are thought to regulate GlyT2 numbers in the pre-synaptic plasma membrane. (nih.gov)
  • These beneficial effects of the calpain inhibitors were associated with restoration of normal phosphorylation levels of the transcription factor CREB and involved redistribution of the synaptic protein synapsin I. Thus, calpain inhibition may prove useful in the alleviation of memory loss in AD. (nih.gov)
  • Since synapsin is a target of protein kinase A (PKA), we assayed whether activity-dependent synaptic growth is regulated via a cAMP/PKA/synapsin pathway. (jneurosci.org)
  • Furthermore, we investigated the role of the presynaptic protein synapsin in activity-dependent synaptic growth. (jneurosci.org)
  • Direct studies of synaptic terminals have been hampered by technical constraints. (nih.gov)
  • Anatomical studies suggest that cholinergic terminals signal predominantly through non-synaptic volume transmission. (nih.gov)
  • Have you got the nerve to explore synaptic transmission? (films.com)
  • To examine the trafficking of synapsin during synaptic growth, we generated transgenic animals expressing fluorescently tagged synapsin. (jneurosci.org)
  • Here was show that calpain inhibition through E64, a cysteine protease inhibitor, and the highly specific calpain inhibitor BDA-410 restored normal synaptic function both in hippocampal cultures and in hippocampal slices from the APP/PS1 mouse, an animal model of AD. (nih.gov)
  • Jones, MV & Westbrook, GL 1996, ' The impact of receptor desensitization on fast synaptic transmission ', Trends in Neurosciences , vol. 19, no. 3, pp. 96-101. (elsevierpure.com)
  • However, the abnormal electroretinogram recorded in this patient also suggested that the dysregulation of the GCAP1-cyclase complex further propagates to the synaptic terminal, thereby altering the ON-pathway related to the b-wave generation. (unicatt.it)
  • 5. Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. (nih.gov)
  • We examined axo-axonal transmission from CINs onto dopaminergic axons using perforated-patch recordings, which revealed rapid spontaneous EPSPs with properties characteristic of fast synapses. (nih.gov)
  • Two hours following thermal pretreatment, hyperthermia-induced increases in spontaneous transmission frequency remained significantly lower than those in tissues undergoing hyperthermia for the first time (p (sicb.org)
  • We pretreated preparations with forskolin to raise cAMP levels and found this manipulation significantly enhanced activity-dependent synaptic growth in control but not Syn(−) preparations. (jneurosci.org)
  • Remarkably, axEPSPs triggered spontaneous action potentials, suggesting that these axons perform integration to convert synaptic input into spiking, a function associated with somatodendritic compartments. (nih.gov)
  • These data indicate that exposure of nervous tissue to temperatures experienced during high fever or heat stroke induces an acclimatory response opposing extreme deviation from normal frequencies of spontaneous synaptic transmission. (sicb.org)
  • The generic process that allows sensory stimuli to pass around our body is known as Synaptic Transmission . (anat.org.au)