AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
SympathomimeticsTyramineEphedrineSympatholyticsCarteololPindololReserpinePhenylpropanolamineCeliprololSynephrineMephentermineOxymetazolineMetaproterenolAdrenergic beta-AntagonistsIsoproterenolVascular HeadachesTolazolineNorepinephrineAmino AlcoholsPropranololPharmacologyPhentolamineEpinephrinePhenoxybenzaminePhenylephrineMetaraminolIproniazidPhenethylaminesTranylcypromineMethoxaminePropanolaminesTerbutalineTretoquinolNictitating MembranePrenalterolDextroamphetaminePseudoephedrineMonoamine Oxidase InhibitorsBetaxololReceptors, AdrenergicAdrenergic alpha-AgonistsXamoterolDesipraminePhenelzinePractololOxprenololHeart RateMioticsEthanolaminesAdrenergic beta-AgonistsAdrenergic beta-1 Receptor AntagonistsPupilMethamphetamineFenoterolCocaineHeartAmphetamineAtenololMetoprololCatecholaminesGuinea PigsVas DeferensAlbuterolAminesStimulation, ChemicalClenbuterolMonoamine OxidaseBronchodilator AgentsBlood PressureCatsMuscle ContractionSympathetic Nervous SystemResearchRabbits
Sympathomimetics
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Ephedrine
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Sympatholytics
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Carteolol
A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
Pindolol
A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Phenylpropanolamine
A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
Celiprolol
A cardioselective beta-1 adrenergic antagonist that has intrinsic symopathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION.
Synephrine
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
Mephentermine
A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
Oxymetazoline
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
Metaproterenol
A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
Adrenergic beta-Antagonists
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Isoproterenol
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Vascular Headaches
Secondary headache disorders attributed to a variety of cranial or cervical vascular disorders, such as BRAIN ISCHEMIA; INTRACRANIAL HEMORRHAGES; and CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS.
Tolazoline
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Amino Alcohols
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
Propranolol
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
Pharmacology
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
Phentolamine
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Phenoxybenzamine
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Phenylephrine
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Metaraminol
A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
Iproniazid
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
Phenethylamines
A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
Tranylcypromine
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Methoxamine
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
Propanolamines
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
Terbutaline
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Tretoquinol
An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
Nictitating Membrane
A fold of the mucous membrane of the CONJUNCTIVA in many animals. At rest, it is hidden in the medial canthus. It can extend to cover part or all of the cornea to help clean the CORNEA.
Prenalterol
A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME.
Dextroamphetamine
The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
Pseudoephedrine
A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
Monoamine Oxidase Inhibitors
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Betaxolol
A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
Receptors, Adrenergic
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
Adrenergic alpha-Agonists
Drugs that selectively bind to and activate alpha adrenergic receptors.
Xamoterol
A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist.
Desipramine
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Phenelzine
One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.
Practolol
A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
Oxprenolol
A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
Heart Rate
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Miotics
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.
Ethanolamines
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
Adrenergic beta-Agonists
Drugs that selectively bind to and activate beta-adrenergic receptors.
Adrenergic beta-1 Receptor Antagonists
Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
Pupil
The aperture in the iris through which light passes.
Methamphetamine
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
Fenoterol
An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Heart
The hollow, muscular organ that maintains the circulation of the blood.
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Atenolol
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
Metoprolol
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Catecholamines
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Guinea Pigs
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Vas Deferens
The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.
Albuterol
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
Amines
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Stimulation, Chemical
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Clenbuterol
A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
Monoamine Oxidase
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Bronchodilator Agents
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Blood Pressure
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Cats
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Kinetic analysis of drug-receptor interactions of long-acting beta2 sympathomimetics in isolated receptor membranes: evidence against prolonged effects of salmeterol and formoterol on receptor-coupled adenylyl cyclase. (1/590)

The long-acting beta2 sympathomimetics salmeterol and formoterol have been presumed to exert their prolonged action either by binding to an accessory binding site ("exo-site") near the beta2 adrenoceptor or by their high affinity for beta2 adrenoceptors and correspondingly slow dissociation. Whereas most studies with salmeterol had been done in intact tissues, which have slow diffusion and compartmentation of drugs in lipophilic phases, that restrict drug access to the receptor biophase, we used purified receptor membranes from rat lung and disaggregated calf tracheal myocytes as model systems. Binding experiments were designed to measure the slow dissociation of agonists by means of delayed association of (-)-[125I]iodopindolol. Rat lung membranes were pretreated with high concentrations of agonists (salmeterol, formoterol, isoprenaline) before dissociation was induced by 50-fold dilution. Half-times of association of (-)-[125I]iodopindolol remained unchanged compared with untreated controls, indicating that dissociation of agonists occurred in less than 2 min. Adenylyl cyclase experiments were designed to determine the on and off kinetics of agonists to beta2 adrenoceptors by measuring the rate of receptor-induced cyclic AMP (cAMP) formation. Experiments were performed in tracheal membranes characterized by high Vmax values of cAMP formation. Adenylyl cyclase activation occurred simultaneously with the addition of the agonist, continued linearly with time for 60 min, and ceased immediately after the antagonist was added. Similarly, when receptor membranes were preincubated in a small volume with high salmeterol concentrations, there was a linear increase in cAMP formation, which was immediately interrupted by a 100-fold dilution of the reaction mixture. This militates against the exo-site hypothesis. On the other hand, dissociation by dilution was much less when membranes were preincubated with a large volume of salmeterol at the same concentration, indicating that physicochemical effects, and not exo-site binding, underlie its prolonged mode of action.  (+info)

Long-term effects of prior heat shock on neuronal potassium currents recorded in a novel insect ganglion slice preparation. (2/590)

Brief exposure to high temperatures (heat shock) induces long-lasting adaptive changes in the molecular biology of protein interactions and behavior of poikilotherms. However, little is known about heat shock effects on neuronal properties. To investigate how heat shock affects neuronal properties we developed an insect ganglion slice from locusts. The functional integrity of neuronal circuits in slices was demonstrated by recordings from rhythmically active respiratory neurons and by the ability to induce rhythmic population activity with octopamine. Under these "functional" in vitro conditions we recorded outward potassium currents from neurons of the ventral midline of the A1 metathoracic neuromere. In control neurons, voltage steps to 40 mV from a holding potential of -60 mV evoked in control neurons potassium currents with a peak current of 10.0 +/- 2.5 nA and a large steady state current of 8.5 +/- 2.6 nA, which was still activated from a holding potential of -40 mV. After heat shock most of the outward current inactivated rapidly (peak amplitude: 8.4 +/- 2.4 nA; steady state: 3.6 +/- 2.0 nA). This current was inactivated at a holding potential of -40 mV. The response to temperature changes was also significantly different. After changing the temperature from 38 to 42 degrees C the amplitude of the peak and steady-state current was significantly lower in neurons obtained from heat-shocked animals than those obtained from controls. Our study indicates that not only heat shock can alter neuronal properties, but also that it is possible to investigate ion currents in insect ganglion slices.  (+info)

Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. (3/590)

1. The aim of the present study was to analyse the cardiovascular actions of the synthetic CB1/CB2 cannabinoid receptor agonist WIN55212-2, and specifically to determine its sites of action on sympathetic cardiovascular regulation. 2. Pithed rabbits in which the sympathetic outflow was continuously stimulated electrically or which received a pressor infusion of noradrenaline were used to study peripheral prejunctional and direct vascular effects, respectively. For studying effects on brain stem cardiovascular regulatory centres, drugs were administered into the cisterna cerebellomedullaris in conscious rabbits. Overall cardiovascular effects of the cannabinoid were studied in conscious rabbits with intravenous drug administration. 3. In pithed rabbits in which the sympathetic outflow was continuously electrically stimulated, intravenous injection of WIN55212-2 (5, 50 and 500 microg kg(-1)) markedly reduced blood pressure, the spillover of noradrenaline into plasma and the plasma noradrenaline concentration, and these effects were antagonized by the CB1 cannabinoid receptor-selective antagonist SR141716A. The hypotensive and the sympathoinhibitory effect of WIN55212-2 was shared by CP55940, another mixed CB1/CB2 cannabinoid receptor agonist, but not by WIN55212-3, the enantiomer of WIN55212-2, which lacks affinity for cannabinoid binding sites. WIN55212-2 had no effect on vascular tone established by infusion of noradrenaline in pithed rabbits. 4. Intracisternal application of WIN55212-2 (0.1, 1 and 10 microg kg(-1)) in conscious rabbits increased blood pressure and the plasma noradrenaline concentration and elicited bradycardia; this latter effect was antagonized by atropine. 5. In conscious animals, intravenous injection of WIN55212-2 (5 and 50 microg kg(-1)) caused bradycardia, slight hypotension, no change in the plasma noradrenaline concentration, and an increase in renal sympathetic nerve firing. The highest dose of WIN55212-2 (500 microg kg(-1)) elicited hypotension and tachycardia, and sympathetic nerve activity and the plasma noradrenaline concentration declined. 6. The results obtained in pithed rabbits indicate that activation of CB1 cannabinoid receptors leads to marked peripheral prejunctional inhibition of noradrenaline release from postganglionic sympathetic axons. Intracisternal application of WIN55212-2 uncovered two effects on brain stem cardiovascular centres: sympathoexcitation and activation of cardiac vagal fibres. The highest dose of systemically administered WIN55212-2 produced central sympathoinhibition; the primary site of this action is not known.  (+info)

Induction of neurally mediated syncope with adenosine. (4/590)

BACKGROUND: Tilt testing is used to establish the diagnosis of neurally mediated syncope. However, applicability of the tilt test is limited by test sensitivity and length of time required to perform the test. We hypothesized that adenosine could facilitate the induction of neurally mediated syncope through its sympathomimetic effects and therefore could be used as an alternative to routine tilt testing. METHODS AND RESULTS: In protocol 1, the yield of adenosine tilt testing (12 mg while upright, followed by 60 degrees tilt for 5 minutes) and a 15-minute isoproterenol tilt test were compared in 84 patients with a negative 30-minute drug-free tilt test. In protocol 2, 100 patients underwent an initial adenosine tilt test followed by our routine tilt test (30-minute drug-free tilt followed by a 15-minute isoproterenol tilt). Six additional control patients underwent microneurography of the peroneal nerve to compare the sympathomimetic effects during bolus administration of adenosine and continuous infusion of isoproterenol. In protocol 1, the yields of adenosine (8 of 84, 10%) and isoproterenol (7 of 84, 8%) tilt testing were comparable (P=NS). In protocol 2, the yields of adenosine (19 of 100, 19%) and routine (22 of 100, 22%) tilt testing were also comparable (P=NS). Although the yield of adenosine tilt testing was comparable in both protocols, patients with a negative adenosine tilt test but a positive routine tilt test usually required isoproterenol to elicit the positive response. Microneurography confirmed discordant sympathetic activation after adenosine and isoproterenol administration. CONCLUSIONS: Adenosine is effective for the induction of neurally mediated syncope, with a diagnostic yield comparable to routine tilt testing. However, the discordant results obtained with adenosine and the isoproterenol phase of routine tilt testing suggest that adenosine and isoproterenol tilt testing may have complementary roles in eliciting a positive response. Therefore, a tilt protocol that uses an initial adenosine tilt followed, if necessary, by an isoproterenol tilt would be expected to increase the overall yield and reduce the duration of tilt testing.  (+info)

Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. (5/590)

BACKGROUND: Steroid-induced gene regulation in the endocrine tissues and vascular wall is achieved through the interaction of specific receptor proteins and promoters of target genes. In addition to these delayed steroid actions, rapid effects of steroids have been reported in various tissues that were clearly incompatible with the classic theory of genomic steroid action. METHODS AND RESULTS: Because high doses of 17beta-estradiol have been shown to modulate intracellular cAMP levels in vascular smooth muscle cells, steroid-induced stimulation of adenylate cyclase stimulation and phosphorylation of cAMP response element binding protein was investigated in porcine coronary artery vascular smooth muscle cells. Aldosterone induces a approximately 1.5- to 2.5-fold increase in intracellular cAMP levels (EC50 approximately 0.01 to 0.1 nmol/L) within 1 minute, whereas 17beta-estradiol and hydrocortisone act only at supraphysiological concentrations (10 micromol/L). Aldosterone-induced changes in intracellular cAMP are calcium dependent; they are not blocked by inhibitors of mineralocorticoid receptors, transcription, or protein synthesis. In addition, aldosterone induces a time-dependent phosphorylation of cAMP response element binding protein with potential transcriptional importance. CONCLUSIONS: A nongenomic modulation of vascular smooth muscle cells by aldosterone is consistent with the data that aldosterone, not estrogen, is the physiological stimulus for cAMP.  (+info)

Utility of a single-stage isoproterenol tilt table test in adults: a randomized comparison with passive head-up tilt. (6/590)

OBJECTIVES: This study was conducted to develop a time-efficient tilt table test. BACKGROUND: Current protocols of tilt table testing are quite time-consuming. This study was designed to assess the diagnostic value, tolerance and procedural time of a single-stage isoproterenol tilt table protocol. METHODS: A single-stage isoproterenol tilt table test was compared with the passive tilt table test. The study was prospectively designed in a randomized and crossover fashion. RESULTS: The study population consisted of 111 patients with a history of syncope (mean age 55 +/- 20 years). Of the total, 62 patients (56%; 95% confidence interval, 46% to 65%) had a positive vasovagal response during isoproterenol tilt table testing and 35 (32%; 23% to 41%) during passive tilt table testing (p = 0.002). The mean procedural times of the study population were 11.7 +/- 3.6 min and 36.9 +/- 13.3 min for isoproterenol and passive tilt table testing, respectively (p < 0.001). All patients tolerated single-stage isoproterenol testing. In the 23 control subjects (mean age 34 +/- 11 years), the apparent specificities were 91% (72% to 99%) and 83% (61% to 99%) for passive and single-stage tilt table testing, respectively. CONCLUSIONS: The single-stage isoproterenol tilt table test was more effective in inducing a positive vasovagal response in an adult population than the standard passive tilt table test, and it significantly reduced the procedural time. The increase in positive yield was associated with a moderate decrease in apparent specificity. These observations support the conclusion that single-stage tilt table testing could be a reasonable diagnostic option in patients undergoing syncope evaluation.  (+info)

Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. II. Effects of noradrenergic and serotoninergic drugs. (7/590)

The effects of serotoninergic and noradrenergic drugs (applied intrathecally) on treadmill locomotion were evaluated in two adult cats subjected to a ventral and ventrolateral spinal lesion (T13). Despite the extensive spinal lesion, severely damaging important descending pathways such as the reticulo- and vestibulospinal tracts, both cats recovered quadrupedal voluntary locomotion. As detailed in a previous paper, the locomotor recovery occurred in three stages defined as early period, when the animal could not walk with its hindlimbs, recovery period, when progressive improvement occurred, and plateau period, when a more stable locomotor performance was observed. At this latter stage, the cats suffered from postural and locomotor deficits, such as poor lateral stability, irregular stepping of the hindlimbs, and inconsistent homolateral fore- and hindlimb coupling. The present study aimed at evaluating the potential of serotoninergic and/or noradrenergic drugs to improve the locomotor abilities in the early and late stages. Both cats were implanted chronically with an intrathecal cannula and electromyographic (EMG) electrodes, which allowed determination, under similar recording conditions, of the locomotor performance pre- and postlesion and comparisons of the effects of different drugs. EMG and kinematic analyses showed that norepinephrine (NE) injected in early and plateau periods improved the regularity of the hindlimb stepping and stabilized the interlimb coupling, permitting to maintain constant locomotion for longer periods of time. Methoxamine, the alpha1-agonist (tested only at the plateau period), had similar effects. In contrast, the alpha2-agonist, clonidine, deteriorated walking. Serotoninergic drugs, such as the neurotransmitter itself, serotonin (5HT), the precursor 5-hydroxytryptophan (5HTP), and the agonist quipazine improved the locomotion by increasing regularity of the hindlimb stepping and by increasing the step cycle duration. In contrast, the 5HT1A agonist 8-hydroxy-dipropylaminotetralin (DPAT) caused foot drag in one of the cats, resulting in frequent stumbling. Injection of combination of methoxamine and quipazine resulted in maintained, regular stepping with smooth movements and good lateral stability. Our results show that the effects of drugs can be integrated to the residual voluntary locomotion and improve some of its postural aspects. However, this work shows clearly that the effects of drugs (such as clonidine) may depend on whether or not the spinal lesion is complete. In a clinical context, this may suggest that different classes of drugs could be used in patients with different types of spinal cord injuries. Possible mechanisms underlying the effect of noradrenergic and serotoninergic drugs on the locomotion after partial spinal lesions are discussed.  (+info)

Topical therapies for glaucoma: what family physicians need to know. (8/590)

Medication classes historically used in the management of glaucoma include beta blockers, miotics, sympathomimetics and carbonic anhydrase inhibitors. Because topically applied medications are more site specific, they are preferred in the treatment of glaucoma. Compared with oral medications, topical agents are associated with a decreased incidence of systemic side effects. With topical administration, conjunctival and localized skin allergic reactions are relatively common, whereas severe reactions, including death, are rare. Recently introduced topical agents for glaucoma therapy include dorzolamide and brinzolamide, the first topical carbonic anhydrase inhibitors; brimonidine and apraclonidine, more ocular-specific alpha agonists; and latanoprost, a prostaglandin analog, which is a new class of glaucoma medication. Latanoprost has the unique side effect of increasing iris pigmentation. Like their predecessors, the newer agents lower intraocular pressure by a statistically significant degree. Preservation of visual field, the more substantial patient-oriented end point, continues to be studied.  (+info)

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https://cheshire.media/headline/1654/sympathomimetic-agents-market-size-development-key-opportunity-application-and-forecast-to-2027-pfizer-sanofi-novartis-sterimax-bedford-pharmaceuticals/
Bucindolol displays intrinsic sympathomimetic activity in human myocardium<...
TY - JOUR. T1 - Bucindolol displays intrinsic sympathomimetic activity in human myocardium. AU - Andréka, P.. AU - Aiyar, Nambi. AU - Olson, Leslie C.. AU - Wei, Jian Qin. AU - Turner, Mark S.. AU - Webster, Keith A.. AU - Ohlstein, Eliot H.. AU - Bishopric, Nanette H.. PY - 2002/5/21. Y1 - 2002/5/21. N2 - Background - Most clinical studies have shown that β-adrenergic receptor antagonists improve long-term survival in heart failure patients. Bucindolol, a nonselective β-receptor blocker, however, failed to reduce heart failure mortality in a recent large clinical trial. The reasons for this failure are not known. Bucindolol has partial agonist properties in rat myocardium, but whether it has agonist activity in human heart is controversial. To address this, we measured the ability of bucindolol to increase cAMP accumulation in human myocardium. Methods and Results - Myocardial strips (≈ 1 mm3) obtained from rat and nonfailing human hearts were confirmed to be viable for ≥48 hours in ...
https://hungary.pure.elsevier.com/hu/publications/bucindolol-displays-intrinsic-sympathomimetic-activity-in-human-m
Intrinsic sympathomimetic activity of β-adrenoceptor blocking agents | SpringerLinkIntrinsic sympathomimetic activity of β-adrenoceptor blocking agents | SpringerLink
The pharmacological methods used to assess the intrinsic sympathomimetic activity (ISA) of β-blockers are discussed. The clinical relevance of ISA to respiratory function, peripheral resistance and...
https://link.springer.com/article/10.1007/BF00606672
Cerebrovascular complications of alcohol and sympathomimetic drug abuse<...
TY - JOUR. T1 - Cerebrovascular complications of alcohol and sympathomimetic drug abuse. AU - Bruno, Askiel. PY - 2003/1/1. Y1 - 2003/1/1. N2 - Alcohol abuse has been linked to intracranial hemorrhage, both intracerebral and subarachnoid. Some studies have found a dose-response relationship, so that increasing levels of abuse are associated with greater risk of hemorrhage. However, alcohol abuse has not been clearly linked to cerebral infarction, and some studies find that mild-to-moderate drinking appears to be associated with a decreased risk of cerebral infarction. Intravenous administration of drugs of abuse predisposes to endocarditis, which may lead to embolic stroke. Associations have been reported between various sympathomimetic drugs and cerebral infarction. A possible mechanism for cerebral infarction is focal arterial vasoconstriction and occasionally cerebral vasculitis. Associations have also been reported between various sympathomimetic drugs and intracranial hemorrhage. A likely ...
https://augusta.pure.elsevier.com/en/publications/cerebrovascular-complications-of-alcohol-and-sympathomimetic-drug
Sympathomimetic Toxicity Medication: Benzodiazepines and other sedatives, Cardiovascular agents, Calcium Channel BlockersSympathomimetic Toxicity Medication: Benzodiazepines and other sedatives, Cardiovascular agents, Calcium Channel Blockers
Poisoning from sympathomimetic agents occurs secondary to the use of prescription and nonprescription agents. The public commonly uses prescription sympathomimetic agents, especially for treating diseases such as asthma and narcolepsy.
https://emedicine.medscape.com/article/818583-medication
Potential benefits of the use of sympathomimetics for asthmatic disease, on semen quality in men of subfertile couples. |...Potential benefits of the use of sympathomimetics for asthmatic disease, on semen quality in men of subfertile couples. |...
The study population of men revealed a mean (± SD) age of 34 ± 4 years with a mean body mass index (BMI) of 26.1 ± 2.3 kg/m, and sympathomimetic use was reported by 3.6%. The use of sympathomimetics was positively associated with a 10% higher sperm motility (beta 10.265; 95% confidence interval [CI] 3.258-17.272) after adjustment for smoking, alcohol use, age, geographic background, BMI, folic acid supplement use, the four astronomical seasons and asthma/bronchitis. Subgroup analysis between men with total motile sperm count (TMSC) < or ≥10 million showed that this association remained (P ≤ 0.001) after adjustment for these confounders. After adjustment for confounders the sperm concentration was also positively associated with the use of sympathomimetics, but only in men with TMSC ≥10 million (beta 0.300; 95% CI 0.032-0.568 ...
https://www.physiciansweekly.com/potential-benefits-of-the-use-of-sympathomimetics-for-asthmatic-disease-on-semen-quality-in-men-of-subfertile-couples/
In Vitro and In Vivo Characterization of Intrinsic Sympathomimetic Activity in Normal and Heart Failure Rats | Journal of...In Vitro and In Vivo Characterization of Intrinsic Sympathomimetic Activity in Normal and Heart Failure Rats | Journal of...
Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.. ...
http://jpet.aspetjournals.org/content/289/1/48/tab-figures-data
What Are Sympathomimetic Amines? | Reference.comWhat Are Sympathomimetic Amines? | Reference.com
Sympathomimetic amines are drugs that stimulate the sympathetic nervous system and induce various responses. These types of drugs can be classified as catecholamines or noncatecholamines....
https://www.reference.com/health/sympathomimetic-amines-ea9c98f22e5559f1
The Asthma Center Education and Research Fund | Disease Information | Asthma | Medical Treatment of Asthma | Sympathomimetic...
Epinephrine is a hormone produced by the adrenal glands (located above the kidneys within the abdomen). The adrenal glands naturally release a very small amount of this substance that may bind to specialized ß2 (beta-2) receptors in the lungs. These receptors, in turn, are responsible for bronchodilation (relaxing of bronchial tube constriction). In addition, epinephrine also can stimulate the heart to beat faster and elevate the blood pressure. If you are asthmatic, you may have a deficiency in the biochemistry of your ß2 receptors. Therefore the amount of natural epinephrine that you produce may be insufficient to promote adequate stimulation and bronchodilation. Sympathomimetic medications stimulate biochemical changes in the airway, which leads to quick relief of asthmatic symptoms as the airway opens. They are reliever medications.. Sympathomimetic medications include:. ...
http://www.theasthmacenter.org/index.php/disease_information/asthma/medical_treatment_of_asthma/sympathomimetic_medications/
Experience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight LossExperience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight Loss
Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
https://www.hindawi.com/journals/jobe/2011/764584/
Armodafinil - WikipediaArmodafinil - Wikipedia
The mechanism of action of armodafinil is unknown. Armodafinil (R-(−)-modafinil) has pharmacological properties almost identical to those of modafinil (a mixture of R-(−)- and (S)-(+)-modafinil). The (R)- and (S)-enantiomers have similar pharmacological action in animals. Armodafinil has wake-promoting actions similar to sympathomimetic agents including amphetamine and methylphenidate, although its pharmacologic profile is not identical to that of the sympathomimetic amines. Armodafinil is an indirect dopamine receptor agonist; it binds in vitro to the dopamine transporter (DAT) and inhibits dopamine reuptake. For modafinil, this activity has been associated in vivo with increased extracellular dopamine levels. In genetically engineered mice lacking the dopamine transporter, modafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent. However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor ...
https://en.wikipedia.org/wiki/Nuvigil
Adrenergic drug synonyms, adrenergic drug antonyms - FreeThesaurus.comAdrenergic drug synonyms, adrenergic drug antonyms - FreeThesaurus.com
Synonyms for adrenergic drug in Free Thesaurus. Antonyms for adrenergic drug. 1 synonym for adrenergic drug: adrenergic. What are synonyms for adrenergic drug?
https://www.freethesaurus.com/adrenergic+drug
Individual beta-blockers for individual patientsIndividual beta-blockers for individual patients
5. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension and of the European Society of Cardiology. (PDF) 2007 Guidelines for the management of arterial hypertension. Eur Heart J 2007; 28: 1462-1536. 6. Agabiti Rosei E, Rizzoni D. Metabolic profile of nebivolol, a beta-adrenoceptor antagonist with unique characteristics. Drugs 2007; 67: 1091-1107. 7. Giugliano D, Acampora R, Marfella R, de Rosa N, Ziccardi P, Ragone R, de Angelis L, dOnofrio F. Metabolic and cardiovascular effects of carvedilol and atenolol in non-insulin-dependent diabetes mellitus and hypertension - a randomized, controlled trial. Ann Intern Med 1997; 126: 955-959. 8. Brixius K, Bundkirchen, Bolck B et al. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol 2001; 133: 1330-1338. 9. Maack C, Tyroller S, Schnabel P, Cremers B, Dabew E, Südkamp M, Böhm M. Characterization of beta-selectivity, ...
https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-6/Individual-beta-blockers-for-individual-patients-Title-Individual-beta-blocke
Oxprenolol - WikipediaOxprenolol - Wikipedia
Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure. Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water-soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol. Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation. Oxprenolol is a beta blocker. In addition, it has been found to act as an antagonist of the serotonin 5-HT1A and 5-HT1B receptors with respective Ki values ...
https://en.wikipedia.org/wiki/Oxprenolol
Benylin Dual Action Dry Syrup | Medicines.ieBenylin Dual Action Dry Syrup | Medicines.ie
4.4 Special warnings and precautions. for use. Benylin Dual Action Dry Syrup may cause. drowsiness. This product should not be used. to sedate a child. If any of the following occur, this product. should be stopped:.  Hallucinations  Restlessness  Sleep disturbances Patients with the following conditions should. be advised to consult a physician before. using this product:.  Susceptibility to angle-closure  Urinary retention or prostatic enlargement,.  A respiratory condition such as emphysema, chronic bronchitis, or. acute or chronic bronchial asthma.. Although pseudoephedrine has virtually no. pressor effects in normotensive patients,. Benylin Dual Action Dry Syrup should be. used with caution in patients taking tricyclic. antidepressants, or other sympathomimetic. agents (such as appetite suppressants and. amphetamine-like psychostimulants). The. physician or pharmacist should check that. sympathomimetic containing preparations are. not simultaneously administered by ...
https://www.medicines.ie/medicines/benylin-dual-action-dry-syrup-31422
Lipomed | Analytical Reference Standards. Amphetamines & Sympathomimetic aminesLipomed | Analytical Reference Standards. Amphetamines & Sympathomimetic amines
Lipomed Inc. is using cookies, to guarantee the best shopping experience. Partially cookies will be set by third parties. Privacy Info ...
https://lipomed-usa.com/en/amphetamine-sympathomimetische-amine
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Norfenefrine - wikidocNorfenefrine - wikidoc
Norfenefrine (INN) or meta-octopamine (3-octopamine), also known as 3,β-dihydroxyphenethylamine, is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico.[1][2] Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring, endogenous trace amine and plays a role as a minor neurotransmitter in the brain.[3] Some brand names for it include Coritat, Energona, Hypolind, and Novadral. ...
https://www.wikidoc.org/index.php/Norfenefrine
Die Wirkung β-adrenerger Substanzen auf die exokrine Funktion des Pankreas | SpringerLinkDie Wirkung β-adrenerger Substanzen auf die exokrine Funktion des Pankreas | SpringerLink
This study reports on effects of β-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein and enzyme...
https://link.springer.com/article/10.1007/BF01851591
Adrenergic Drugs: Types, Uses, and EffectsAdrenergic Drugs: Types, Uses, and Effects
Adrenergic drugs stimulate your sympathetic nervous system. Find out how they treat different conditions by targeting different receptors in this system.
https://www.healthline.com/health/adrenergic-drugs
Basic Pharmacology of Commonly Used Cardiovascularly Active Drugs | CTSNetBasic Pharmacology of Commonly Used Cardiovascularly Active Drugs | CTSNet
The sympathomimetic catecholamines produce effects that depend upon their relative specificity for alpha, beta 1 and beta 2 receptors.. Adrenaline: With both alpha and beta effects this will produce an augmentation in heart rate, systolic blood pressure and cardiac output. In addition it produces relaxation of bronchial smooth muscle. However these effects occur at the expense of increased myocardial oxygen demand and reduced perfusion of skin, kidneys and other organs. It is used for its inotropic effect at doses of 0.01-0.02 μg/kg/min titrated according to response.. Noradrenaline: This has predominantly alpha effects but also slight beta effects on the heart. It produces an increase in both systolic and diastolic pressure but its principle effect is to increase peripheral resistance. This is disadvantageous when peripheral resistance is normal as it then produces an increase in resistance and raises cardiac afterload. However it is useful when the peripheral resistance is inappropriately ...
https://www.ctsnet.org/article/basic-pharmacology-commonly-used-cardiovascularly-active-drugs
Bronchodilators · Part One
This covers the inhaled β-agonists used for bronchodilation. Information on catecholamines and sympathomimetics with activity on β-receptors is covered under adrenergic vasoactives.. ...
http://www.partone.lifeinthefastlane.com/beta_agonists.html
WheezingWheezing
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS ...
https://pharos.nih.gov/idg/diseases/IDG:D4831
Mucinex Childrens Stuffy Nose & Cold Disease Interactions - Drugs.comMucinex Childrens Stuffy Nose & Cold Disease Interactions - Drugs.com
Comprehensive disease interaction information for Mucinex Childrens Stuffy Nose & Cold. Includes Sympathomimetics - Cardiovascular Disease.
https://www.drugs.com/disease-interactions/guaifenesin-phenylephrine,mucinex-children-s-stuffy-nose-cold.html
Alpha-responsive sympathomimetic drugs | definition of alpha-responsive sympathomimetic drugs by Medical dictionaryAlpha-responsive sympathomimetic drugs | definition of alpha-responsive sympathomimetic drugs by Medical dictionary
Looking for online definition of alpha-responsive sympathomimetic drugs in the Medical Dictionary? alpha-responsive sympathomimetic drugs explanation free. What is alpha-responsive sympathomimetic drugs? Meaning of alpha-responsive sympathomimetic drugs medical term. What does alpha-responsive sympathomimetic drugs mean?
http://medical-dictionary.thefreedictionary.com/alpha-responsive+sympathomimetic+drugs
Plus itPlus it
The action of nine sympathomimetic amines on contractility and on phosphorylase a and total phosphorylase activity of the isolated perfused rat heart has been studied. The following observations have been made. 1) The sympathomimetic amines with a positive inotropic action on the heart caused an increase in phosphorylase a activity of the myocarclium, hut did not change total phosphorylase activity. 2) Sympathomimetic amines with no action on the contractility of the heart had no effect on phosphorylase a activity. 3) With each drug studied there was a correlation at all drug concentrations between the increase in systolic isometric tension and the increase of phosphorylase a activity. 4) Linear log dose-response curves were obtained in studies of the action of epinephrine, norepinephrine and isoproterenol on phosphorylase a activity. 5) The structure-activity relationship of the nine drugs was the same for their ability to increase the force of contraction and for their action on phosphorylase. ...
https://jpet.aspetjournals.org/content/127/2/122
Pindolol QuickView - Correlation Engine
Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action ...
https://accounts.public.ce.basespace.illumina.com/b/search/details/Pindolol?type=compound
Stroke associated with ephedrine use | NeurologyStroke associated with ephedrine use | Neurology
Several sympathomimetic agents have been associated with ischemic and hemorrhagic stroke. Ephedrine, a sympathomimetic drug that has a high potential for abuse and can be readily obtained without a prescription in unrestricted quantities, has rarely been associated with stroke. We report ephedrine-related stroke in three patients. One patient developed a thalamic infarct after ingesting known quantities of ephedrine as street-purchased speed for weight loss. Two patients had fatal intracranial hemorrhages after ingesting unknown quantities of ephedrine; one of them had a history of drug abuse, and one lacked a history of ephedrine use or drug abuse. Ephedrine appears to predispose to both ischemic and hemorrhagic stroke. The mechanisms responsible for the different cerebrovascular complications remain to be proven. Restriction of ephedrine availability should be considered.. ...
https://n.neurology.org/content/43/7/1313?ijkey=e19e9d256a295ae6c7de9e40cfd0e23fac6399df&keytype2=tf_ipsecsha
Preludin - Appetite Depressants, Central Nervous System Agents, SympathomimeticsPreludin - Appetite Depressants, Central Nervous System Agents, Sympathomimetics
Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden ...
https://pharmacycode.com/Preludin.html
Acute vasodilator action of pindolol in humans. | HypertensionAcute vasodilator action of pindolol in humans. | Hypertension
The local hemodynamic effect of pindolol, a nonselective beta-blocker with intrinsic sympathomimetic activity, was investigated in 17 healthy volunteers. Changes in forearm blood flow (FBF) in response to infusion of drugs into the brachial artery were measured by plethysmography. Pindolol increased FBF dose dependently to a maximal value of 62 +/- 8% (mean +/- SEM, p less than 0.001) without inducing changes in heart rate or blood pressure. For a single dose of pindolol the maximal effect on FBF was seen after approximately 4 minutes of infusion, and this effect persisted for at least 12 minutes after the infusion. The pindolol-induced increase in FBF was reduced by concomitant infusion of propranolol (p less than 0.001). Intra-arterial infusion of practolol did not influence FBF. No significant influence of pindolol was found on the vasoconstriction induced by the alpha 1-adrenergic receptor agonist methoxamine, the alpha 2-adrenergic receptor agonist BHT-933, or angiotensin II. Measurement of ...
http://hyper.ahajournals.org/content/7/1/146
Bisoprolol QuickView - Correlation Engine
Bisoprolol is a competitive, cardioselective β1-adrenergic antagonist. Activation of β1-receptors (located mainly in the heart) by epinephrine increases heart rate and the blood pressure causing the heart to consume more oxygen. β1-adrenergic blocking agents such as bisopolol lower the heart rate and blood pressure and may be used to reduce workload on the heart and hence oxygen demands. They are routinely prescribed in patients with ischemic heart disease. In addition, β1-selective blockers prevent the release of renin, a hormone produced by the kidneys causes constriction of blood vessels. Bisoprolol is lipophilic and exhibits no intrinsic sympathomimetic activity (ISA) or membrane-stabilizing activity ...
https://accounts.public.ce.basespace.illumina.com/b/search/details/Bisoprolol?type=compound
Bisoprolol - wikidocBisoprolol - wikidoc
Bisoprolol fumarate is a beta1-selective (cardioselective) adrenoceptor blocking agent without significant membrane stabilizing activity or intrinsic sympathomimetic activity in its therapeutic dosage range. Cardioselectivity is not absolute, however, and at higher doses (≥20 mg) bisoprolol fumarate also inhibits beta2-adrenoceptors, chiefly located in the bronchial and vascular musculature; to retain selectivity it is therefore important to use the lowest effective dose. The most prominent effect of bisoprolol fumarate is the negative chronotropic effect, resulting in a reduction in resting and exercise heart rate. There is a fall in resting and exercise cardiac output with little observed change in stroke volume, and only a small increase in right atrial pressure, or pulmonary capillary wedge pressure at rest or during exercise. Findings in short-term clinical hemodynamics studies with bisoprolol fumarate are similar to those observed with other beta-blocking agents. In normal volunteers, ...
http://wikidoc.org/index.php/Bisoprolol
Left Ventricular Hypertrophy. - Semantic ScholarLeft Ventricular Hypertrophy. - Semantic Scholar
The presence of left ventricular hypertrophy (LVH) as a treatable entity is of particular importance in patients with primary hypertension. Because LVH is associated with a strong risk of adverse clinical events (eg, heart failure, ischemic events, and cardiovascular death) and because evidence from retrospective studies suggests that regression of LVH, along with a decrease in blood pressure, may help modify these outcomes, the use of antihypertensive agents that have been shown to promote regression of LVH has been recommended. These include diuretics, beta-blockers (except those with intrinsic sympathomimetic activity ), angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, peripheral alpha(1)-blockers, and central alpha(2)-stimulators. Agents to be avoided include direct arterial vasodilators (eg, hydralazine and minoxidil), which have strong sympathetic stimulating properties and tend to maintain LVH despite lowering blood pressure. The use of ACE inhibitors is increasing.
https://www.semanticscholar.org/paper/Left-Ventricular-Hypertrophy-Liebson/99cb3d20edd6256698095a7d9795f678d700b62e
Acebutolol - A Drug A DayAcebutolol - A Drug A Day
Acebutolol is a medication used to treat hypertension and cardiac arrhythmias. Acebutolol is a cardio selective beta blocker with intrinsic sympathomimetic activity, and so is infinitely more suitable than non-cardioselective beta blockers for patients with chronic obstructive pulmonary disease or asthma due to the fact that doses lower than 800mg daily have only 10-30% of…
https://adrugadayblog.wordpress.com/2017/01/28/acebutolol/
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It was also recommended for some time as out- sound in the earliest phase of the bladder during treatment. There are many other prob- lems in men and women and in genetic makeup). Headaches, dermatitis and eczema (see figure 29.4). Atric urologists as unnecessary intervention. The of the tract. Parations, pyridoxine is dependent on operator skill, patient habitus and 54 f. Porpiglia et al. Monitor the patient about the speci c surface receptors like platelet-derived (kemp et al, vitamin b12 may cause hypokalaemia. 4. Clayman rv, kavoussi lr, jarrett tw. Health span approximates life span among many others). This fascia is attached to mast cells associated with ity. Drug. Where the penis can move through speci c the ability to function to take alcohol with sympathomimetic effects through the drug with food in order to improve the ability. 8 explain how in chilli-pepper- eating competitions, the contestants appear to be a sensible option allowing foreskin preser- it as a by relieving fatigue and ...
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Clenbuterol For Lean Muscles - FullDisclosure
Clenbuterol Hydrochloride is a sympathomimetic that works on the sympathomimetic central nerovosu system. There are several receptors in the body any sympathomimetic can act on. In the case of Clenbuterol, often the beta-2 radiorreceptor is the market and motion. Clen, seeing that its commonly known, make an effort to stimulates the particular beta-2 beneficiario. Through these kinds of stimulation, that actively dos airway things blocking the path and provides superior breathing for those who need it. This same stimulation could also be used to enhance the particular metabolic rate in the individual. Clenbuterol does not definitely burn fat by attacking fat cells, but instead stimulates the actual metabolism through increasing the particular bodys temperatures. This takes place due to the beta-2 stimulation stimulative the mitochondria of the tissue to produce along with release much more heat. Subsequently, this heats the bodys temperature (slightly), enhances the metabolism and causes the ...
http://www.fulldisclosureconsulting.com/clenbuterol-lean-muscles/
Clenbuterol For Slim Muscles - FitnessdeElite
Clenbuterol Hydrochloride is a sympathomimetic that works around the sympathomimetic central nerovosu system. There are several pain in the body some sort of sympathomimetic can certainly act on. Regarding Clenbuterol, the particular beta-2 beneficiario is the specialized niche and actions. Clen, because its typically known, definitely stimulates the beta-2 radio. Through this sort of stimulation, this actively dos airway interferences and provides superior breathing for people who need it. This same stimulation can also be used to enhance the particular metabolic rate of the individual. Clenbuterol does not make an effort to burn fat simply by attacking excess fat cells, but instead stimulates the metabolism by simply increasing typically the bodys temp. This takes place due to the beta-2 stimulation stimulating the mitochondria of the cellular material to produce and release a lot more heat. Therefore, this gets hotter14957 the bodys temperature (slightly), enhances the metabolism and ...
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From MSDS Eyes: Wash eyes with clear, tepid water. If irritation persists, obtain medical attention. Skin: Wash with soap and water. Inhalation: No adverse effects anticipated from normal use. In an abuse situation, remove from source of exposure. Treat symptomatically. Oxygen may be administered. Seek medical attention immediately and refer to Notes to Physician below. Ingestion: Consult a physician. Notes to Physician: If spontaneous vomiting has not occurred and large amounts have been ingested, the physician may at their discretion administer an emetic or mechanically empty the stomach. Cardiac sensitization to propellants may occur. Do not use sympathomimetic agents (e.g. epinephrine) because of possible induction of ventricular fibrillation ...
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Amezinium Methyl Sulfate
Literature References: Sympathomimetic agent with vascular and cardiac activity. Prepn: F. Richenender, R. Kropp, DE 1912941; eidem, US 3631038 (1970, 1971 both to BASF). Series of articles on synthesis, pharmacology, mechanism of action, metabolism, pharmacokinetics, bioavailability, clinical trials: Arzneim.-Forsch. 31, 1527-1671 (1981). Acute toxicity data: H. J. Teschendorf, ibid. 1580. HPLC determn in human plasma: D. Hotz, E. Brode, J. Chromatogr. 277, 217 (1983). Disposition and identification of major metabolites in rats: K. Nambu et al., Arzneim.-Forsch. 38, 909 (1988). ...
https://www.drugfuture.com/chemdata/Amezinium-Methyl-Sulfate.html
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Four general types of the ischial spine (in accutane topix the colon) formed carcinogens with the enzyme essential for the same. Autosomal adj. Allergy 2. Sampson ha. Steatorrhea and deficiency syndromes have also been protaminated to produce fever, a hypersensitivity reaction is affected, aspiration and dilation and curettage of the reticular formation, midbrain, thalamus and the perceived lightness being approximately s-shaped. 1172 cesarean scar pregnancy is a personal or family history has not diagnosis of appendicitis. Bdz receptor agonists (sympathomimetic agents) which directly stimulate the mucosal cells with a row how many reps and sets i can recommend to their direct lympholytic action are called high machs and people who are interested in medical management, and associated conditions physical and mental deterioration, alcohol addiction can be performed at harvard university under the acute stage are: A. Prevent ignorance or unawareness of hemiplegic is incomplete without mentioning ...
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Alcohol & Substance Abuse | Pilot Medical Solutions - LeftSeat.comAlcohol & Substance Abuse | Pilot Medical Solutions - LeftSeat.com
The diagnosis or history of: Alcoholism, Substance Dependence, or Substance Abuse is disqualifying in the absence of favorable clinical evidence. According to the FAA, Substance includes: Alcohol; other sedatives and hypnotics; anxiolytics; opiods; central nervous system stimulant such as cocaine, amphetamines, and similarly acting sympathomimetic; hallucinogens; phencyclidine or similarly acting arylcyclohexylamines; cannabis; inhalants; and other psychoactive drugs and chemicals. The FAA defines Substance dependence as: A condition in which a person is dependent on a substance, other than tobacco or ordinary xanthine-containing (e.g., caffeine) beverages as evidenced by: Increased tolerance Manifestation of withdrawal symptoms Impaired control of use; or continued use despite damage to physical health or impairment of social, personal, or occupational functioning These issues typically require documentation of sustained abstinence and a psychiatric evaluation performed in compliance with FAA
https://www.leftseat.com/alcohol-substance-abuse/
MedGen for PubMed (Select 20633205) - MedGen - NCBIMedGen for PubMed (Select 20633205) - MedGen - NCBI
A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of an addictive substance, e.g. opioids, barbiturates and alcohol; amphetamines or similarly acting sympathomimetics; cocaine; nicotine; sedatives, hypnotics, or anxiolytics. Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions. [from NCI] ...
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Clenbuterol 40 mg/60 tab - Balkan Pharmaceuticals - Steroidsbesthgh.com
Clenbuterol belongs to a class of drugs known as sympathomimetics. These drugs affect the sympathetic nervous system in numerous ways. It is specifically a selective beta-2 sympathomimetic, stimulating the beta-2 receptors, which creates a thermogenic effect, directly stimulating fat cells and accelerating the breakdown of triglycerides to form free fatty acids. Animal studies have also shown it to be quite anti-catabolic and/or anabolic which obviously leads to its attractiveness amongst bodybuilders - particularly during the pre-contest phase. However, it has to be said that these studies have been restricted to animals and there is little real evidence of Clenbuterol having muscle building/sparingproperties in humans. This does little to tarnish its reputation as a great adjunct anabolic - used both off-season and pre-contest.. ...
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51-43-4
Literature References: Endogenous catcholamine with combined a- and b-agonist activity. Principal sympathomimetic hormone produced by the adrenal medulla. Isoln from animal adrenal glands: Takamine, J. Soc. Chem. Ind. 20, 746 (1901); Aldrich, Am. J. Physiol. 5, 457 (1901). Synthesis of dl-form: Stolz, Ber. 37, 4149 (1904); Payne, Ind. Chem. 37, 523 (1961). Historic review of syntheses: Loewe, Arzneim.-Forsch. 4, 583 (1954). Resolution of dl-form: Fl?cher, Z. Physiol. Chem. 58, 189 (1908). Configuration: Pratesi et al., J. Chem. Soc. 1958, 2069. Acute toxicity: A. M. Lands et al., J. Pharmacol. Exp. Ther. 90, 110 (1947). HPLC determn in plasma and urine: C. R. Benedict, J. Chromatogr. 385, 369 (1987). Comprehensive description: D. H. Szulczewski, W.-H. Hong, Anal. Profiles Drug Subs. 7, 193-229 (1978). Physiologic review: Malmejac, Physiol. Rev. 44, 186 (1964). Review of biosynthesis: L. A. Pohorecky, R. J. Wurtman, Pharmacol. Rev. 23, 1-35 (1971); of pharmacology and clinical use in ...
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Advances in Treatment of Heart Failure - WSAVA2002 - VINAdvances in Treatment of Heart Failure - WSAVA2002 - VIN
Pimobendan. Newer Heart Failure Therapy. Pimobendan. Most positive inotropes increase the cytosolic concentration of calcium to increase the availability of calcium, but pimobendan has the novel action of increasing the sensitivity of the contractile proteins to calcium, an effect thought to be mediated by altering the binding of calcium to the troponin complex, and the increase in the extent of sarcomere shortening is achieved without the same energy consumption associated with sympathomimetic drugs. Pimobendan has both calcium sensitizing effects and some phosphodiesterase inhibitory effects. The calcium sensitizing effects appear to predominate in failing myocardium, because of down-regulation of the adrenergic signaling pathway. The phosphodiesterase inhibition also results in vasodilation. Phosphodiesterases are involved in the breakdown of cAMP in vascular smooth muscle, and inhibitors of these phosphodiesterases will cause venodilation and arteriodilation. There has been no significant ...
http://www.vin.com/apputil/content/defaultadv1.aspx?pId=11147&id=3846143
most interesting drug for case study - Molecular Biologymost interesting drug for case study - Molecular Biology
Absorption isnt so easy. I can think of some interesting interactions. For example if taking an MAO inhibitor (e.g., clorgyline) then the ingestion of sympathomimetic amines (e.g. amphetamine or even tyramine from cheese) will increase their [amines] apparent absorption as there is no longer functional MAO in the gut epithelium to degrade it. This can lead to the cheese effect which results in severe hypertension, flushing and can be fatal ...
http://www.protocol-online.org/biology-forums/posts/14395.html
Clenbuterol- An Effective Fat Burning DrugRatedekhoClenbuterol- An Effective Fat Burning DrugRatedekho
In the field of sports, strength and stamina are very vital for an athlete. Clenbuterol or Clen is a very effective metabolism booster.It has been a favorite choice of athletes and bodybuilders for years in burning fat. Some people believe that Clenbuterol injections are the best way to take this drug. Weight loss using Clenbuterol hydrochloride injections leads to a high risk. Many people shots of Clenbuterol for bodybuilding and it can be taken as a pill or liquid or an injectable form.. Clenbuterol also improves the production of catabolic hormone secretion (epinephrine, norepinephrine and dopamine) which further stimulate the transformation of fat and calories into heat.Catabolic hormones alter the contractile nature of smooth muscle. Clenbuterol decreases and reverses the effects of insulin, which releases glycogen into the bloodstream. It is an injectable sympathomimetic amine and it has an intense anti-catabolic effect which improves the cardiovascular capacity. This leads to increase in, ...
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Patent US4127118 - Method of effecting and enhancing an erection - Google PatentsPatent US4127118 - Method of effecting and enhancing an erection - Google Patents
A method of alleviating and treating male impotence by effecting and enhancing an erection by injecting into the penis an appropriate vasodilator, a sympathomimetic amine, or an adrenergic blocking agent.
http://www.google.com.au/patents/US4127118
Minijet isoprenaline (discontinued in the UK)Minijet isoprenaline (discontinued in the UK)
Isoprenaline hydrochloride is a beta-adrenergic agonist which has a powerful stimulant action on the heart, increasing cardiac output and heart rate. It also increases blood flow to the limbs and extremities. Isoprenaline is a sympathomimetic medicine that dilates the small air passages in the lungs and improves the transmission of electrical signals in the heart. This medicine is given intravenously as an emergency treatment for serious heart disorders.
http://www.netdoctor.co.uk/medicines/heart-and-blood/a7104/minijet-isoprenaline-discontinued-in-the-uk/
Epinephrine Isopropyl Homolog - Cardiotonic Agents, Bronchodilator Agents, Sympathomimetic, ATC:R03ACEpinephrine Isopropyl Homolog - Cardiotonic Agents, Bronchodilator Agents, Sympathomimetic, ATC:R03AC
Lisoprotérénol est un relativement sélectif bêta2-adrénergiques bronchodilatateur. Lisoprotérénol est indiqué pour le soulagement des bronchospasmes associés aux maladies pulmonaires obstructives chroniques. Le pharmacologiques effets des bêta-adrénergique médicaments, y compris lisoprotérénol, sont au moins en partie attribuable à la stimulation par le biais des récepteurs bêta-adrénergiques adénylcyclase intracellulaire, lenzyme qui catalyse la conversion de ladénosine triphosphate (ATP) pour cyclique-3 , 5-adénosine monophosphate (AMP-c). Augmentation de c-AMP niveaux sont associées à la relaxation des muscles lisses bronchiques et une inhibition de la libération des médiateurs de lhypersensibilité immédiate à partir des cellules, en particulier par les mastocytes ...
https://pharmacycode.com/fr/Epinephrine_Isopropyl_Homolog.html
Dexa-Rhinaspray Duo (discontinued in the UK - July 2007)Dexa-Rhinaspray Duo (discontinued in the UK - July 2007)
Tramazoline hydrochloride belongs to a group of medicines called sympathomimetics, which work by stimulating alpha-receptors in certain areas of the body. When applied as a nasal spray, tramazoline acts on the alpha receptors in the walls of blood vessels in the nose. This causes them to narrow and results in less blood travelling through the vessels in the nose. This in turn, decreases the amount of fluid pushed out into the nasal lining, and so reducing mucus secretionDexamethasone belongs to a group of medicines known as corticosteroids, used for reducing inflammation. Inflammation occurs as a result of allergy or irritation and is caused by the release of substances that are important in the immune system. These substances cause blood vessels to widen, resulting in the affected area becoming red, swollen, itchy and painful. Dexamethasone when applied as a nasal spray works by acting within cells to decrease the release of these substances in the nose, thereby reducing swelling, redness and itch
https://www.netdoctor.co.uk/medicines/allergy-asthma/a6548/dexa-rhinaspray-duo-discontinued-in-the-uk-july-2007/
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Ventolin is a sympathomimetic bronchodilator that relaxes the smooth muscle in the airways which allows air to flow in and out of the... more. ...
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TravelSafe Clinic - Travel Health, Yellow Fever Disease & Vaccination.: Leptospirosis in Mumbai & other parts of Maharashtra -...TravelSafe Clinic - Travel Health, Yellow Fever Disease & Vaccination.: Leptospirosis in Mumbai & other parts of Maharashtra -...
I am a pediatrician based at Mohali, a suburb of chandigarh, North India. I have my own virtual office at www.charakclinics.com; I have been a pediatrician since 1994. I hope to make ths blog a regular feature with tonnes of relevant info for parents, especially in India, because i feel that informed parents are better parents. My interests include research in OPD practice, specifically new vaccines and travel medicine. I am a member of American Academy of Pediatrics, Indian Academy of Pediatrics, and various travel organizations like International Society for Travel Medicine (ISTM), American Society of Tropical Medicine & Hygiene (ASTMH), International Association for Medical Assistance to Travelers (IAMAT), and British & Global Travel Health Association (BGTHA ...
http://yellowfevervaccine.blogspot.com/2015/09/leptospirosis-in-mumbai-other-parts-of.html
PAN Pesticide Use Info for BoysenberriesPAN Pesticide Use Info for Boysenberries
Acres Treated is the acreage of the crop actually treated with the pesticide. Gross Pounds applied divided by Acres Treated is the application rate of the pesticide. The difference between Acres Planted and Acres Treated is best explained through an example:If a farmer has a 100-acre field and sprays 50 acres, then the Acres Planted will be 100 and the Acres Treated will be 50. If a farmer sprays 50 of their 100 acres three times, then the Acres Planted will remain at 100 acres, but now the value of Acres Treated will be 150. This figure may not be the total acreage of the selected crop. See documentation for further distinctions between acres treated and acres planted ...
http://www.pesticideinfo.org/DS.jsp?sk=1003
Sympathomimetic drugSympathomimetic drug
For maximum sympathomimetic activity, a drug must have: Amine group two carbons away from an aromatic group A hydroxyl group at ... Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other ... The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α- ... Thus, all sympathomimetic amines fall into the larger group of stimulants (see psychoactive drug chart). In addition to ...
https://en.wikipedia.org/wiki/Sympathomimetic_drug
Vasculitic neuropathyVasculitic neuropathy
Drugs (amphetamines, sympathomimetics, cocaine, etc.) Vaccinations. Non-systemic vasculitic neuropathy (NSVN) is a diagnosis of ...
https://en.wikipedia.org/wiki/Vasculitic_neuropathy
Adrenergic stormAdrenergic storm
Sympathomimetic drug King, Andrew; Dimovska, Mirjana; Bisoski, Luke (24 February 2018). Oparil, Suzanne (ed.). "Sympathomimetic ... Lam, Vivian; Shaffer, Robert W. (2017). "8. Management of Sympathomimetic Overdose Including Designer Drugs". In Hyzy, Robert C ... Foreword by Fahrad N. Kapadia) (31 May 2019). "Chapter 8: Sympathomimetic Drugs". In Singh, Omender; Juneja, Deven (eds.). ... Goldstein, Scott; Richards, John R. (1 January 2020). Richards, John R. (ed.). Sympathomimetic Toxicity. Treasure Island, ...
https://en.wikipedia.org/wiki/Adrenergic_storm
DextroamphetamineDextroamphetamine
Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... Dextroamphetamine, along with other sympathomimetics, was eventually classified as Schedule II, the most restrictive category ... Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine, 4-hydroxynorephedrine, and norephedrine. The ...
https://en.wikipedia.org/wiki/Dextroamphetamine
AmphetamineAmphetamine
... produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine, 4-hydroxynorephedrine, and norephedrine. The ... Table 2. Decongestants Causing Rhinitis Medicamentosa - Nasal decongestants: - Sympathomimetic: • Amphetamine "FDA Drug Safety ...
https://en.wikipedia.org/wiki/Amphetamine
StimulantStimulant
Pseudoephedrine is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/ ... Ephedrine is a sympathomimetic amine similar in molecular structure to the well-known drugs phenylpropanolamine and ... Most drugs classified as stimulants are sympathomimetics, that is they stimulate the sympathetic branch of the autonomic ... Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ...
https://en.wikipedia.org/wiki/Stimulant
MethamphetamineMethamphetamine
Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... Among these metabolites, the active sympathomimetics are amphetamine, 4‑hydroxyamphetamine, 4‑hydroxynorephedrine, 4- ...
https://en.wikipedia.org/wiki/Methamphetamine
LisdexamfetamineLisdexamfetamine
Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine, 4-hydroxynorephedrine, and norephedrine. The ... "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). Goodman & Gilman's Pharmacological ...
https://en.wikipedia.org/wiki/Lisdexamfetamine
Respiratory centerRespiratory center
Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ...
https://en.wikipedia.org/wiki/Respiratory_center
AdderallAdderall
Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... Among these metabolites, the active sympathomimetics are 4-hydroxyamphetamine, 4-hydroxynorephedrine, and norephedrine. The ...
https://en.wikipedia.org/wiki/Adderall
Psychoactive drugPsychoactive drug
Chapter 36 - Caffeine and Related Nonprescription Sympathomimetics. ISBN 0-7216-5485-1[page needed] Kanazawa, Kazuki; ...
https://en.wikipedia.org/wiki/Psychoactive_drug
MedicationMedication
Diagnostic: topical anesthetics, sympathomimetics, parasympatholytics, mydriatics, cycloplegics. Antibacterial: antibiotics, ... Antibiotics, sympathomimetics, antihistamines, anticholinergics, NSAIDs, corticosteroids, antiseptics, local anesthetics, ...
https://en.wikipedia.org/wiki/Medication
Autonomic drugAutonomic drug
The action of sympathomimetic drugs can be classified as direct and indirect action. The direct mode of activating adrenergic ... Sympathomimetic drugs are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system ... Terbutaline is a type of sympathomimetic drug. Terbutaline is a selective β2 receptor agonist that is clinically used to treat ... Drugs affecting the sympathetic nervous system can be divided into 2 main categories: sympathomimetic drugs which mimics the ...
https://en.wikipedia.org/wiki/Autonomic_drug
OxymetazolineOxymetazoline
A direct sympathomimetic, oxymetazoline binds to and activates α1 adrenergic receptors and α2 adrenergic receptors, most ... Retrieved 24 January 2015.. Biaggioni I, Robertson D. "Chapter 9. Adrenoceptor Agonists & Sympathomimetic Drugs". In Katzung BG ... Since imidazolines are sympathomimetic agents, their primary effects appear on α adrenergic receptors, with little if any ... Oxymetazoline is a sympathomimetic that selectively agonizes α1 and, partially, α2 adrenergic receptors. Since vascular beds ...
https://en.wikipedia.org/wiki/Oxymetazoline
FluorolintaneFluorolintane
Analogs of Sympathomimetic Amines". Journal of the American Chemical Society. 75 (14): 3409-3413. doi:10.1021/ja01110a033. v t ... depression and as sympathomimetic. AD-1211 Diphenidine Ephenidine Lanicemine Methoxphenidine (MXP) MT-45 Prolintane Remacemide ...
https://en.wikipedia.org/wiki/Fluorolintane
Inositol trisphosphateInositol trisphosphate
Biaggioni I., Robertson D. (2011). Chapter 9. Adrenoceptor Agonists & Sympathomimetic Drugs. In: B.G. Katzung, S.B. Masters, A. ...
https://en.wikipedia.org/wiki/Inositol_trisphosphate
DosulepinDosulepin
Sympathomimetics may potentiate the sympathomimetic effects of dosulepin. Due to the anticholinergic and antihistamine effects ...
https://en.wikipedia.org/wiki/Dosulepin
PseudoephedrinePseudoephedrine
... (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a ... It has also been reported that pseudoephedrine, among other sympathomimetic agents, may be associated with the occurrence of ... Cantu C, Arauz A, Murillo-Bonilla LM, López M, Barinagarrementeria F (July 2003). "Stroke associated with sympathomimetics ... Beta-adrenergic antagonists may also interact with sympathomimetics. Increase of ectopic pacemaker activity can occur when ...
https://en.wikipedia.org/wiki/Pseudoephedrine
BuphenineBuphenine
Freedman L (1955). "Arlidin: a new vasodilative sympathomimetic drug". Angiology. 6 (1): 52-8. doi:10.1177/000331975500600106. ... Külz F, Schneider M (1950). "Über neue gefäßerweiternde Sympathomimetika" [On new vasodilative sympathomimetics]. Klin ...
https://en.wikipedia.org/wiki/Buphenine
OxilofrineOxilofrine
Külz F, Schneider M (1950). "Über neue gefäßerweiternde Sympathomimetika" [On new vasodilating sympathomimetics]. Klin ... Freedman L (1955). "Arlidin: a new vasodilative sympathomimetic drug". Angiology. 6 (1): 52-8. doi:10.1177/000331975500600106. ...
https://en.wikipedia.org/wiki/Oxilofrine
N,N-DimethyldopamineN,N-Dimethyldopamine
I. Sympathomimetic and related amines." J. Med. Chem. 9 273-280. L. I. Goldberg, P. F. Sonneville, and J. L. McNay (1968). "An ...
https://en.wikipedia.org/wiki/N,N-Dimethyldopamine
LabetalolLabetalol
... possesses intrinsic sympathomimetic activity. In particular, it is a partial agonist at beta2- receptors located in ...
https://en.wikipedia.org/wiki/Labetalol
Muzafer MujićMuzafer Mujić
... (born 1931) is a Bosnian physiologist known for his contributions to classification of sympathomimetic drugs and ... van Rossum, J. M.; Mujić, M. (June 1965). "Classification of sympathomimetic drugs on the rabbit intestine". Archives ... Mujić, M.; van Rossum, J. M. (June 1965). "Comparative pharmacodynamics of sympathomimetic imidazolines; studies on intestinal ... His early research interests included basic research in classification of sympathomimetic drugs and comparative ...
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MetoprololMetoprolol
... it is without intrinsic sympathomimetic activity; and it decreases heart rate, contractility, and cardiac output, thereby ...
https://en.wikipedia.org/wiki/Metoprolol
SympatholyticSympatholytic
... has intrinsic sympathomimetic activity) Pindolol (has intrinsic sympathomimetic activity) Propranolol Sotalol Timolol β1- ... Sympathomimetic drug "Dorlands Medical Dictionary:sympatholytic". Brock, JA; Cunnane, TC (November 1988). "Studies on the mode ... selective agents Acebutolol (has intrinsic sympathomimetic activity) Atenolol Betaxolol Bisoprolol Celiprolol Esmolol ...
https://en.wikipedia.org/wiki/Sympatholytic
BromantaneBromantane
... has low peripheral sympathomimetic effects. Moreover, no signs of [bromantane] dependence and withdrawal symptoms were found." ... As such, bromantane has few to no side effects (including peripheral sympathomimetic effects and hyperstimulation), does not ...
https://en.wikipedia.org/wiki/Bromantane
SynephrineSynephrine
... s are direct sympathomimetic drugs while the ephedrines are both direct and indirect sympathomimetics. One of the ... As a pharmaceutical, m-synephrine (phenylephrine) is still used as a sympathomimetic (i.e. for its hypertensive and ... McCulloch J, Deshmukh VD, Harper AM (1978). "Indirect sympathomimetic agents and cerebral blood flow and metabolism". European ... Papp L. Szekeres (1968). "The arrhythmogenic action of sympathomimetic amines". European Journal of Pharmacology. 3 (1): 4-14. ...
https://en.wikipedia.org/wiki/Synephrine
ProcaterolProcaterol
Bull., 28, 3441 (1980). Yoshizaki S, Tanimura K, Tamada S, Yabuuchi Y, Nakagawa K (September 1976). "Sympathomimetic amines ...
https://en.wikipedia.org/wiki/Procaterol
Responsible drug useResponsible drug use
"Human EnhancementR: SmithKline Beecham: Dextroamphetamine Sulfate: Sympathomimetic" (PDF). RxMed. June 29, 2009 Yes, addicts ... "DexedrineR: SmithKline Beecham: Dextroamphetamine Sulfate: Sympathomimetic". RxMed. " ...
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Calcium channel blocker toxicityCalcium channel blocker toxicity
Slow heart rate can be treated with atropine and sympathomimetics. Low blood pressure is treated with vasopressors such as ...
https://en.wikipedia.org/wiki/Calcium_channel_blocker_toxicity
Sympathomimetic Toxicity Differential DiagnosesSympathomimetic Toxicity Differential Diagnoses
The public commonly uses prescription sympathomimetic agents, especially for treating diseases such as asthma and narcolepsy. ... Poisoning from sympathomimetic agents occurs secondary to the use of prescription and nonprescription agents. ... encoded search term (Sympathomimetic Toxicity) and Sympathomimetic Toxicity What to Read Next on Medscape ... Sympathomimetic Toxicity Differential Diagnoses. Updated: Mar 02, 2021 * Author: Paul Kolecki, MD, FACEP; Chief Editor: Asim ...
https://emedicine.medscape.com/article/818583-differential
Systemic Mastocytosis Medication: Antineoplastics, Tyrosine Kinase Inhibitor, Sympathomimetics, Mast Cell Stabilizers,...Systemic Mastocytosis Medication: Antineoplastics, Tyrosine Kinase Inhibitor, Sympathomimetics, Mast Cell Stabilizers,...
Erowid.org: Erowid Reference 8355 : Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone ...Erowid.org: Erowid Reference 8355 : Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone ...
Liechti ME Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone) ... We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with ... "Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone (naphthylpyrovalerone)". ... naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity.. Key Words: CNS, amphetamine, stimulant, ...
https://www.erowid.org/references/refs_view.php?ID=8355
Sympathomimetic medications: Nursing Pharmacology | OsmosisSympathomimetic medications: Nursing Pharmacology | Osmosis
Learn and reinforce your understanding of Sympathomimetic medications: Nursing Pharmacology. ... Sympathomimetic medications: Nursing Pharmacology Videos, Flashcards, High Yield Notes, & Practice Questions. ... Clients on sympathomimetics may also experience gastrointestinal side effects, such as nausea and vomiting. Sympathomimetics ... SYMPATHOMIMETIC MEDICATIONS, PART 2/2. DRUG NAME. epinephrine (Adrenalin,. Adrenaclick, Epipen). norepinephrine (Levophed). ...
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Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room...
Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room ... Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room ...
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IMSEAR at SEARO: INHIBITION OF PERISTALTIC REFLEX BY SYMPATHOMIMETIC DRUGS.
INHIBITION OF PERISTALTIC REFLEX BY SYMPATHOMIMETIC DRUGS. Indian Journal of Physiology and Pharmacology. 1963 Oct; 7(): 224-34 ...
https://imsear.searo.who.int/handle/123456789/106898?locale=es
Tardive Dyskinesia: Overview, Pathophysiology, EtiologyTardive Dyskinesia: Overview, Pathophysiology, Etiology
Although blepharospasm has been reported with dopaminergic and sympathomimetic agents and antihistamines, it has also been ...
https://emedicine.medscape.com/article/1151826-overview
Sympathomimetic Toxicity Differential DiagnosesSympathomimetic Toxicity Differential Diagnoses
The public commonly uses prescription sympathomimetic agents, especially for treating diseases such as asthma and narcolepsy. ... Poisoning from sympathomimetic agents occurs secondary to the use of prescription and nonprescription agents. ... encoded search term (Sympathomimetic Toxicity) and Sympathomimetic Toxicity What to Read Next on Medscape ... Sympathomimetic Toxicity Differential Diagnoses. Updated: Mar 02, 2021 * Author: Paul Kolecki, MD, FACEP; Chief Editor: Asim ...
https://emedicine.staging.medscape.com/article/818583-differential
Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties: A Hint of a Possible Mechanism<...Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties: A Hint of a Possible Mechanism<...
Zimlichman R, Krauss S, Paran E. Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties: A Hint ... Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties : A Hint of a Possible Mechanism. / ... Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties: A Hint of a Possible Mechanism. ... Zimlichman, R., Krauss, S., & Paran, E. (1991). Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity ...
https://cris.bgu.ac.il/en/publications/muscle-cramps-induced-by-%CE%B2-blockers-with-intrinsic-sympathomimeti
DailyMed - LEVOTHYROXINE SODIUM tabletDailyMed - LEVOTHYROXINE SODIUM tablet
7.7 Sympathomimetics Concurrent use of sympathomimetics and levothyroxine sodium tablets may increase the effects of ... 7.7 Sympathomimetics 7.8 Tyrosine-Kinase Inhibitors 7.9 Drug-Food Interactions 7.10 Drug-Laboratory Test Interactions 8 USE IN ... Thyroid hormones may increase the risk of coronary insufficiency when sympathomimetic agents are administered to patients with ... Monitor patients receiving concomitant levothyroxine sodium tablets and sympathomimetic agents for signs and symptoms of ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=75d77bc7-151a-74b8-e053-2991aa0a9278
Sinucon Disease Interactions - Drugs.comSinucon Disease Interactions - Drugs.com
Sympathomimetics (applies to Sinucon) BPH. Moderate Potential Hazard, High plausibility. Applicable conditions: Benign ... Sympathomimetics (applies to Sinucon) cardiovascular disease. Major Potential Hazard, High plausibility. Applicable conditions ... Sympathomimetic agents may cause adverse cardiovascular effects, particularly when used in high dosages and/or in susceptible ... Sympathomimetic agents may cause or worsen urinary difficulty in patients with prostate enlargement due to smooth muscle ...
https://www.drugs.com/disease-interactions/chlorpheniramine-phenylephrine-phenylpropanolamine-phenyltoloxamine,sinucon.html
Which of the following sympathomimetics is an effective mydriatic? | DrlogyWhich of the following sympathomimetics is an effective mydriatic? | Drlogy
A.Salmeterol, B.Phenylephrine, C.Dobutamine, D.Norepinephrine, E.
https://drlogy.com/vet-mcq/which-of-the-following-sympathomimetics-is-an-effective-mydriatic
Interactions between Aventyl Oral and tricyclic-compounds-selected-direct-acting-sympathomimeticsInteractions between Aventyl Oral and tricyclic-compounds-selected-direct-acting-sympathomimetics
... provides information about interactions between Aventyl Oral and tricyclic-compounds-selected-direct-acting-sympathomimetics. ... Selected Direct-Acting Sympathomimetics/Tricyclic Compounds Interactions. This information is generalized and not intended as ... Interactions between sympathomimetic amines and antidepressant agents in man. Br Med J 1973 Feb 10;1(5849):311-5. ... 2.Ghose K. Sympathomimetic amines and tricyclic antidepressant drugs. Neuropharmacology 1980 Dec;19(12):1251-4. ...
http://origin-www.webmd.com/drugs/2/drug-6172/aventyl-oral/details/list-interaction-details/dmid-2712/dmtitle-tricyclic-compounds-selected-direct-acting-sympathomimetics/intrtype-drug
Dr. Thomas Tarshis, MD - Child & Adolescent Psychiatry Specialist in San Jose, CA | HealthgradesDr. Thomas Tarshis, MD - Child & Adolescent Psychiatry Specialist in San Jose, CA | Healthgrades
Nondependent Amphetamine or Related Acting Sympathomimetic Abuse. *Nondependent Antidepressant Abuse. *Nondependent Cocaine ...
https://www.healthgrades.com/physician/dr-thomas-tarshis-xlq8y
Acute Poisonings from Synthetic Cannabinoids - 50 U.S. Toxicology Investigators Consortium Registry Sites, 2010-2015 | MMWRAcute Poisonings from Synthetic Cannabinoids - 50 U.S. Toxicology Investigators Consortium Registry Sites, 2010-2015 | MMWR
Sympathomimetic syndrome. 5.4. Other. 2.2. Abbreviation: SC = synthetic cannabinoid.. * A total of 456 reported cases (at 50 ...
https://www.cdc.gov/mmwr/volumes/65/wr/mm6527a2.htm
Cocaine intoxication: MedlinePlus Medical EncyclopediaCocaine intoxication: MedlinePlus Medical Encyclopedia
Cocaine and other sympathomimetics. In: Walls RM, ed. Rosens Emergency Medicine: Concepts and Clinical Practice. 10th ed. ...
https://medlineplus.gov/ency/article/000946.htm
Treatment of a simulated child with anaphylaxis: an in situ two-arm studyTreatment of a simulated child with anaphylaxis: an in situ two-arm study
Anaphylaxis is a life-threatening presentation and requires prompt recognition and appropriate adrenaline administration. Junior medical staff may require more emphasis on recognition and prompt adrenaline administration in both undergraduate and in hospital training and education. Simulated scenari …
https://pubmed.ncbi.nlm.nih.gov/23758136/
Amyotrophic Lateral Sclerosis Treatment & Management: Approach Considerations, Inpatient and Outpatient Care, Pharmacologic...Amyotrophic Lateral Sclerosis Treatment & Management: Approach Considerations, Inpatient and Outpatient Care, Pharmacologic...
Sympathomimetics such as pseudoephedrine may be tried if tolerated; 30-60 mg may be administered as needed or 120-240 mg/day of ...
https://emedicine.medscape.com/article/1170097-treatment
Neo-Synephrine 12 Hour Spray - Adrenergic alpha-Agonists, Nasal Decongestants, Sympathomimetics, ATC:R01AA05...Neo-Synephrine 12 Hour Spray - Adrenergic alpha-Agonists, Nasal Decongestants, Sympathomimetics, ATC:R01AA05...
... direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline ...
https://pharmacycode.com/Neo-Synephrine_12_Hour_Spray.html
Nicotine poisoning: MedlinePlus Medical EncyclopediaNicotine poisoning: MedlinePlus Medical Encyclopedia
Cocaine and other sympathomimetics. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosens Emergency Medicine: Concepts and ...
https://medlineplus.gov/ency/article/002510.htm
Lisdexamfetamine - WikipediaLisdexamfetamine - Wikipedia
Amphetamine produces central stimulant, anorectic, and sympathomimetic actions, and it is the prototype member of this class ( ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC (eds.). ... the active sympathomimetics are 4-hydroxyamphetamine,[85] 4-hydroxynorephedrine,[86] and norephedrine.[87] The main metabolic ...
https://en.wikipedia.org/wiki/Lisdexamfetamine
Trichloroethylene (TCE) | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Avoid sympathomimetics or catecholamines or use them with caution. Beta-blockers may be more effective than lidocaine in cases ... However, the use of sympathomimetic agents such as epinephrine and isoproterenol could precipitate fatal dysrhythmias and ... However, the use of sympathomimetic agents such as epinephrine and isoproterenol could precipitate fatal dysrhythmias and ... However, the use of sympathomimetic agents such as epinephrine and isoproterenol could precipitate fatal dysrhythmias and ...
https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=168&toxid=30
Acute Urticaria Medication: H1 Antagonists (first-generation antihistamines), H1 Antagonists (second-generation antihistamines)...
Sympathomimetic Agents. Class Summary. These agents cause vasoconstriction and reduction in vascular dilation, which ...
https://www.staging.medscape.com/answers/137362-93321/which-medications-in-the-drug-class-monoclonal-antibodies-anti-asthmatics-are-used-in-the-treatment-of-acute-urticaria
Sudal SR oral Interactions with Other MedicationSudal SR oral Interactions with Other Medication
SYMPATHOMIMETICS/ERGOT ALKALOIDS Moderate Interactions These medications may cause some risk when taken together. Consult your ... SYMPATHOMIMETICS (INDIRECT & MIXED ACTING)/MAOIS Serious Interactions These medications may interact and cause very harmful ...
https://www.webmd.com/drugs/2/drug-64643/sudal-sr-oral/details/list-interaction-medication
R)-adrenaline (CHEBI:28918)R)-adrenaline (CHEBI:28918)
... has role sympathomimetic agent (CHEBI:35524) (R)-adrenaline (CHEBI:28918) has role vasoconstrictor ... sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in ... sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in ... It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28918
Motion Sickness | CDC Yellow Book 2024
... and sympathomimetics (often used in combination with antihistamines). ...
https://wwwnc.cdc.gov/travel/yellowbook/2024/air-land-sea/motion-sickness
Erowid.org: Erowid Reference 9167 : Two cases of severe intoxication associated with analytically confirmed use of the novel...Erowid.org: Erowid Reference 9167 : Two cases of severe intoxication associated with analytically confirmed use of the novel...
... which likely account for their serotonergic and sympathomimetic symptoms. The clinical testing of NBOMe drugs is not commonly ...
https://erowid.org/references/refs_view.php?ID=9167&S=benzodiazepines&SField=All
February 1979 - Volume 23 - Issue 1 : Survey of AnesthesiologyFebruary 1979 - Volume 23 - Issue 1 : Survey of Anesthesiology
Sympathomimetic Effects of Cocaine and Their Influence on Halothane and Enflurane Anesthesia. CHUNG, B.; NARAGHI, M.; ADRIANI, ...
https://journals.lww.com/surveyanesthesiology/toc/1979/02000
EpiPen (Epinephrine) - Injection: Uses, Side Effects, Dosages, InteractionsEpiPen (Epinephrine) - Injection: Uses, Side Effects, Dosages, Interactions
AminesEpinephrineTricyclic AntidepressantsToxicityDRUGSHypertensionNasal congestionAdrenergicAntihistaminesStimulantAgentsCocaineDrugMECHANISMAmineToxicityIntrinsic sympathomimetic activityAnticholinergicsDrugsPhenylephrineAppetite SuppressantsBronchodilatorsClenbuterolIndirectDecongestantsMetabolismAnticholinergicDecongestantBronchodilatorVasoconstrictorSympathetic nervouTheophyllineNeurotransmittersMimicReceptorsMedicationOxymetazolinePeripheralEphedrine hydrochlorideAsthmaSupraventricularEffectsAction
Amines6
  • Therapy with sympathomimetic agents should generally be avoided or administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, or underlying cardiovascular or cerebrovascular disorders. (drugs.com)
  • Interactions between sympathomimetic amines and antidepressant agents in man. (webmd.com)
  • 2.Ghose K. Sympathomimetic amines and tricyclic antidepressant drugs. (webmd.com)
  • Adderall is sympathomimetic amines based medicine used for Attention deficit hyperactivity disorder and Narcolepsy. (affordable-drugs-rx.com)
  • Concomitant use of CETAL SINUS with tricyclic antidepressants, sympathomimetic agents (such as decongestants, appetite suppressants and amfetamine-like psychostimulants) or with monoamine oxidase inhibitors, which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure (see Contraindications ). (eipico.com.eg)
  • Some interactions between sympathomimetic amines and amine-depleting agents on the schedule-controlled behavior of the pigeon and the squirrel monkey. (bvsalud.org)
Epinephrine3
  • Sympathomimetics are medications that mimic the effect of endogenous catecholamines, like norepinephrine and epinephrine . (osmosis.org)
  • Epinephrine is an alpha- and beta-adrenergic agonist (sympathomimetic agent). (verywellhealth.com)
  • Sympathomimetic drugs mimic the results of the hormone epinephrine (adrenaline) and norepinephrine (noradrenaline). (justiceweaver.com)
Tricyclic Antidepressants1
  • Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. (lambertvetsupply.com)
Toxicity3
  • O'Connor AD, Padilla-Jones A, Gerkin RD, Levine M. Prevalence of Rhabdomyolysis in Sympathomimetic Toxicity: a Comparison of Stimulants. (medscape.com)
  • We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. (erowid.org)
  • Based on the present case report and user web-reports, as well as on the chemical structure and pharmacological characteristics, naphyrone produces stimulant-like psychotropic effects and sympathomimetic toxicity. (erowid.org)
DRUGS1
  • Phentermine and the other sympathomimetic drugs for weight loss are mistakenly stigmatized because their structures superficially resemble amphetamine. (medscape.com)
Hypertension1
  • As with other sympathomimetic agents CETAL SINUS should be used with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement. (eipico.com.eg)
Nasal congestion1
  • Oxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. (pharmacycode.com)
Adrenergic1
  • The NBOMe compounds are highly potent 5HT2A receptor agonists and are also agonists at alpha-adrenergic receptors, which likely account for their serotonergic and sympathomimetic symptoms. (erowid.org)
Antihistamines1
  • and sympathomimetics (often used in combination with antihistamines). (cdc.gov)
Stimulant1
  • Clenbuterol does not belong to anabolic steroids, this drug is a stimulant that belongs to the sympathomimetic group. (ottawascoutingmuseum.org)
Agents5
  • Sympathomimetic agents are used in the treatment of anaphylaxis. (medscape.com)
  • Sympathomimetic agents may cause adverse cardiovascular effects, particularly when used in high dosages and/or in susceptible patients. (drugs.com)
  • Enhanced sarcoplasmic reticulum ca: moderate sympathomimetic agents. (manguerascartagenasas.com)
  • Gjedde s, crystalloids, clonidine: moderate sympathomimetic agents. (manguerascartagenasas.com)
  • Alpha-Blockers: moderate sympathomimetic agents. (manguerascartagenasas.com)
Cocaine1
Drug1
  • Clen or Clenbuterol Hydrochloride is classified as a sympathomimetic drug. (justiceweaver.com)
MECHANISM1
  • Zimlichman, R, Krauss, S & Paran, E 1991, ' Muscle Cramps Induced by β-Blockers With Intrinsic Sympathomimetic Activity Properties: A Hint of a Possible Mechanism ', Archives of Internal Medicine , vol. 151, no. 5, pp. 1021. (bgu.ac.il)
Amine10
  • Dobutamine is a sympathomimetic amine with stronger beta than alpha effects. (medscape.com)
  • In general, when dealing with sympathomimetic compounds, a primary or secondary aliphatic amine separated by 2 carbons from a substituted benzene ring is minimally required for high agonist activity. (bodybuilding.com)
  • Significantly increase adrenergic, dopaminergic and serotonergic neurotransmitters by acting as an indirect sympathomimetic amine. (bodybuilding.com)
  • Ephedrine tablet 30mg is a sympathomimetic amine and an alkaloid frequently used as a decongestant for the treatment of asthma, obesity or during surgery to maintain high blood pressure. (jasonscottpharmaceuticals.net)
  • Ephedrine tablet 30mg is a sympathomimetic amine and an alkaloid frequently used as a decongestant derived from plant s of the genus Ephedra (family Ephedraceae). (jasonscottpharmaceuticals.net)
  • Ephedrine tablet 30mg is a sympathomimetic amine - that is, its main mechanism of action is related to its indirect action on the adrenergic receptor system. (jasonscottpharmaceuticals.net)
  • Prescribing, dispensing, or administering an amphetamine or sympathomimetic amine drug, except for specified conditions. (domyassignment24x7.com)
  • While many people categorize it as a steroid, it is in fact part of the sympathomimetic amine group, sarms bulk stack. (rosespeech.com)
  • An anavar clen cycle combines the anabolic androgenic steroid anavar (oxandrolone) with clenbuterol, a sympathomimetic amine that belongs to the drug class of bronchodilators. (genesisnutrition.ca)
  • The anavar molecule is known to enhance the effects of the anabolic steroids, and the clenbuterol molecule (which is also known as clonidine) is known as a sympathomimetic amine that binds to and suppresses the sympathetic nervous system. (genesisnutrition.ca)
Toxicity5
  • "Dissociative and sympathomimetic toxicity associated with recreational use of 1-3-trifluoromethylphenyl piperazine TFMPP and 1-benzylpiperzine BZP" J Med Toxicol . (erowid.org)
  • They presented with dissociative-type symptoms, nausea, and signs consistent with sympathomimetic toxicity. (erowid.org)
  • "Recreational Use of Mephedrone 4-Methylmethcathinone, 4-MMC with Associated Sympathomimetic Toxicity" J Med Toxicol . (erowid.org)
  • Shortly after the injection, he developed palpitations, 'blurred tunnel vision,' chest pressure, and sweating and felt generally unwell he presented to hospital with continuing features of sympathomimetic toxicity. (erowid.org)
  • Prevalence of Rhabdomyolysis in Sympathomimetic Toxicity: a Comparison. (erowid.org)
Intrinsic sympathomimetic activity3
  • Celiprolol differs from atenolol in that it has an intrinsic sympathomimetic activity (ISA) for beta 1 -adrenoceptors, which is reflected in its relative lack of negative inotropic effects in humans. (monash.edu)
  • Celiprolol differs from atenolol in that it has an intrinsic sympathomimetic activity (ISA) for beta1-adrenoceptors, which is reflected in its relative lack of negative inotropic effects in humans. (monash.edu)
  • It has no significant intrinsic sympathomimetic activity, and has only weak local anesthetic (membrane-stabilizing) and myocardial depressant activity. (drugbank.com)
Anticholinergics2
  • These include a number of both prescription and recreational drugs such as cocaine, amphetamines, anticholinergics, and sympathomimetics. (renalandurologynews.com)
  • Other common medications used to treat motion sickness are anticholinergics such as scopolamine (hyoscine-oral, intranasal, and transdermal), antidopaminergic drugs (such as prochlorperazine), metoclopramide, sympathomimetics, and benzodiazepines. (cdc.gov)
Drugs4
  • Classical sympathomimetic drugs are amphetamines (including MDMA ), ephedrine and cocaine, which act by blocking and reversing norepinephrine transporter (NET) activity. (bionity.com)
  • Sympathomimetic drugs may also work by inhibiting the opposite system, i.e. the parasympathetic system. (bionity.com)
  • Sympathomimetic drugs, also known as adrenergic agonists, mimic the action of the stimulators (α, β, or dopamine receptors) of the sympathetic autonomic nervous system. (lecturio.com)
  • Sympathomimetic drugs are classified based on the type of receptors the drugs act on (some agents act on several receptors but 1 is predominate). (lecturio.com)
Phenylephrine3
  • e that has unique effects due to its indirect mechanism compared to other sympathomimetic agents like pseudoephedrine and phenylephrine. (buurtcappello.com)
  • Like pseudoephedrine, phenylephrine is a sympathomimetic drug, meaning it stimulates receptors of the sympathetic nervous system. (medpagetoday.com)
  • Tell your doctor if you are allergic or have had any reaction to other sympathomimetics such as ephedrine or phenylephrine. (newhealthadvisor.org)
Appetite Suppressants14
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  • Natural Sympathomimetic Appetite Suppressants women go, and its hard to get to the sky if you want to meet some glamorous scenes! (kemea.be)
  • The processing tasks of the hydraulic press have been fully arranged, and Blythe Michaud also spent a lot of time to coordinate, and only then did he win In the calm and peaceful work, the subprime mortgage crisis sympathomimetic appetite suppressants and more serious Tomi Coby lowered the window discount rate by 50 basis points to 5. (kaikaibrai.com)
Bronchodilators2
  • Other short-acting sympathomimetic bronchodilators should not be used concomitantly with ProAir Respiclick. (medicinenet.com)
  • Clenbuterol je sympathomimetic amina, koja se uglavnom nalazi u bronchodilators i proizvodi koji se smanjiti simptomi astme i hopb. (larusa.org)
Clenbuterol1
  • How To Use Testosterone Testosterone is the most important hormone in male enhancement, as it is responsible for creating muscles, clenbuterol sympathomimetic drug. (yatuta.ru)
Indirect3
  • 4) Ephedrine has indirect sympathomimetic effects and due to its ability to cross the blood-brain. (buurtcappello.com)
  • Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
  • Ephedrine is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. (bookriff.com)
Decongestants2
  • Belongs to the class of sympathomimetics used as ophthalmologic decongestants. (mims.com)
  • R01AA05 - oxymetazoline : Belongs to the class of topical sympathomimetic agents used as nasal decongestants. (mims.com)
Metabolism1
  • Inhibition of norepinephrine metabolism can produce sympathomimetic effects. (bionity.com)
Anticholinergic2
  • Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. (bestbets.org)
  • Combivent Aerosol is a combination of a beta-adrenergic (sympathomimetic) bronchodilator and an anticholinergic bronchodilator. (pharm-europe.com)
Decongestant2
  • Pseudoephedrine is a decongestant (sympathomimetic). (webmd.com)
  • The active substance has sympathomimetic, vasoconstrictive and decongestant properties. (midas-pharma.com)
Bronchodilator1
  • Clen is a veterinary-grade sympathomimetic bronchodilator. (woho.org)
Vasoconstrictor2
  • High-level prescribing trends for Vasoconstrictor sympathomimetics (BNF section 2.7.2) across all GP practices in NHS England for the last five years. (openprescribing.net)
  • all data on Vasoconstrictor sympathomimetics or data on Vasoconstrictor sympathomimetics by CCG . (openprescribing.net)
Sympathetic nervou1
  • Sympathomimetics may produce a wide range of adverse effects, which generally resemble excessive stimulation of the sympathetic nervous system. (lecturio.com)
Theophylline1
  • Although important atrial and ventricular dysrhythmias were demonstrated in a majority of these patients, the relationship of these rhythm disturbances to concomitant drug therapy, particularly theophylline compounds or sympathomimetics, was not evaluated. (pascoaching.com)
Neurotransmitters1
  • Over time, the heart will adapt to the large amounts of blood that are being pumped, which leads to blood vessel expansion mediated by the release of sympathomimetic neurotransmitters. (conqueror.blog)
Mimic1
  • If your pet is having difficulty with vision due to Horner's syndrome, your veterinary ophthalmologist may prescribe eye drops called sympathomimetics that mimic the sympathetic system supply. (eyecareforanimals.com)
Receptors1
  • Direct stimulation of the α- and β-adrenergic receptors can produce sympathomimetic effects. (bionity.com)
Medication1
  • Pediacare Drops is a brand name medication included in a group of medications called Sympathomimetics . (rxwiki.com)
Oxymetazoline1
  • Xylomethazoline (Otrivin®), oxymetazoline (Dampo®, Nasivin®) en tramazoline (Rhinospray®)hebben een decongestief effect op het neusslijmvlies door hun alfa-adrenerge werking. (semanticscholar.org)
Peripheral1
  • It s mechanisms of action imply that it acts as a peripheral sympathomimetic compound. (bodybuilding.com)
Ephedrine hydrochloride1
Asthma1
  • Clinical uses of sympathomimetics include the treatment of hypotension, asthma, and anaphylaxis. (lecturio.com)
Supraventricular1
  • Cardiovascular effects, such as cardiac arrhythmias e.g. supraventricular tachycardia and extrasystoles may be seen with sympathomimetic medicinal products including FF/VI. (webwire.com)
Effects2
  • With many millions of patients treated per year and drawing parallels to the lately discovered risks of sibutramine, another sympathomimetic with an overlapping mode of action and similar side effects on heart rate and blood pressure, we hypothesize that such a trial might be a dedicated risk mitigation strategy for public health. (springernature.com)
  • Pseudoephedrine's sympathomimetic effects on the heart and circulatory system can cause side effects. (newhealthadvisor.org)
Action1
  • Ephedrine 's basic pharmacological action is that of a sympathomimetic. (buurtcappello.com)
Beta-Blocker Toxicity: Practice Essentials, Pathophysiology, Epidemiology
Beta-Blocker Toxicity: Practice Essentials, Pathophysiology, Epidemiology (medscape.com)
Pharmacotherapy for Nonallergic Rhinitis: Overview, Distinguishing Types of Nonallergic Rhinitis, Pharmacotherapy
Pharmacotherapy for Nonallergic Rhinitis: Overview, Distinguishing Types of Nonallergic Rhinitis, Pharmacotherapy (emedicine.medscape.com)
Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology (emedicine.medscape.com)
These highlights do not include all the information needed to use LEVOTHYROXINE SODIUM TABLETS safely and effectively. See full...
These highlights do not include all the information needed to use LEVOTHYROXINE SODIUM TABLETS safely and effectively. See full... (dailymed.nlm.nih.gov)
Heat Stroke: Practice Essentials, Pathophysiology, Etiology
Heat Stroke: Practice Essentials, Pathophysiology, Etiology (medscape.com)
Amyotrophic Lateral Sclerosis Treatment & Management: Approach Considerations, Inpatient and Outpatient Care, Pharmacologic...
Amyotrophic Lateral Sclerosis Treatment & Management: Approach Considerations, Inpatient and Outpatient Care, Pharmacologic... (medscape.com)
Hypertension Clinical Presentation: History, Physical Examination, Hypertension and Cerebrovascular Disease
Hypertension Clinical Presentation: History, Physical Examination, Hypertension and Cerebrovascular Disease (medscape.com)
Hypertension: Practice Essentials, Background, Pathophysiology
Hypertension: Practice Essentials, Background, Pathophysiology (medscape.com)
Hypertension: Practice Essentials, Background, Pathophysiology
Hypertension: Practice Essentials, Background, Pathophysiology (medscape.com)
RTECS:IO1750000 - 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro,endo,exo- - The...
RTECS:IO1750000 - 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro,endo,exo- - The... (cdc.gov)
Intoxicación con nicotina: MedlinePlus enciclopedia médica
Intoxicación con nicotina: MedlinePlus enciclopedia médica (medlineplus.gov)
Sickle Cell Disease (SCD) Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion
Sickle Cell Disease (SCD) Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion (medscape.com)
Carcinogenicity of Acetaldehyde & Malonaldehyde & Mutagenicity of Related Low-Molecular-Weight Aldehydes | NIOSH | CDC
Carcinogenicity of Acetaldehyde & Malonaldehyde & Mutagenicity of Related Low-Molecular-Weight Aldehydes | NIOSH | CDC (cdc.gov)
Amyotrophic Lateral Sclerosis: Practice Essentials, Background, Pathophysiology
Amyotrophic Lateral Sclerosis: Practice Essentials, Background, Pathophysiology (medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
DailyMed - METOLAZONE tablet
DailyMed - METOLAZONE tablet (dailymed.nlm.nih.gov)
Marplan
Marplan (dailymed.nlm.nih.gov)
METOLAZONE TABLETS, USP
METOLAZONE TABLETS, USP (dailymed.nlm.nih.gov)
(dailymed.nlm.nih.gov)