Survival Rate
Cell Survival
Disease-Free Survival
Survival
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Graft Survival
Treatment Outcome
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Neoplasm Staging
Proportional Hazards Models
Follow-Up Studies
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Prognosis
Neoplasm Recurrence, Local
Multivariate Analysis
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Immunohistochemistry
Neoplasm Metastasis
Risk Factors
Prospective Studies
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Chemotherapy, Adjuvant
Disease Progression
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Cells, Cultured
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Lymphatic Metastasis
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Registries
Carcinoma, Non-Small-Cell Lung
Fluorouracil
Transplantation, Homologous
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Doxorubicin
Colorectal Neoplasms
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Carcinoma, Squamous Cell
Survival of Motor Neuron 1 Protein
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
Gene Expression Regulation, Neoplastic
Mutation
Neoplasms
Graft Rejection
Actuarial Analysis
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Disease Models, Animal
Drug Administration Schedule
Risk Assessment
Radiotherapy, Adjuvant
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Remission Induction
Life Tables
Microbial Viability
Liver Transplantation
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Ovarian Neoplasms
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Reverse Transcriptase Polymerase Chain Reaction
Carcinoma
Proto-Oncogene Proteins
Cell Death
SEER Program
A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)
Blotting, Western
Dose-Response Relationship, Drug
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mice, Transgenic
Prednisone
Phosphorylation
Gene Expression Profiling
Cell Differentiation
Postoperative Complications
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Phosphatidylinositol 3-Kinases
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Tissue Donors
Neoadjuvant Therapy
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Cell Division
Incidence
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Drug Resistance, Neoplasm
Analysis of Variance
Models, Biological
Reoperation
Cause of Death
Tumor Suppressor Protein p53
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Survival of Motor Neuron 2 Protein
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Protein-Serine-Threonine Kinases
Neurons
Tumor Cells, Cultured
bcl-X Protein
Cardiopulmonary Resuscitation
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
Salvage Therapy
Up-Regulation
Neoplasm Grading
Methotrexate
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Dacarbazine
Randomized Controlled Trials as Topic
Chi-Square Distribution
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Heart Arrest
Paclitaxel
Mice, Nude
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Phenotype
Tissue Array Analysis
Nerve Growth Factors
Survivors
Gene Expression
Carcinoma, Renal Cell
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Receptor, erbB-2
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Transplantation, Autologous
DNA-Binding Proteins
Antineoplastic Agents, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Sarcoma
Regression Analysis
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Treatment Failure
Tumor Burden
Leukemia, Myeloid, Acute
Patient Selection
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sex Factors
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Lymph Node Excision
Oligonucleotide Array Sequence Analysis
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Severity of Illness Index
Enzyme Activation
Taxoids
Leucovorin
Lymph Nodes
Enzyme Inhibitors
Transfection
Lymphoma, Non-Hodgkin
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Cell Movement
Gene Expression Regulation
Bone Marrow Transplantation
Down-Regulation
Transcription Factors
Neoplasm Transplantation
Caspase 3
Clinical Trials, Phase III as Topic
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
In Situ Nick-End Labeling
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Organoplatinum Compounds
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Immunoenzyme Techniques
Receptor, Epidermal Growth Factor
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Xenograft Model Antitumor Assays
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. (1/735)
Previous work has shown that there is a positive correlation between the induction of Hsp70 and its transient nuclear localization and the acquisition and loss of induced thermotolerance in postimplantation rat embryos. To determine whether Hsp70 is sufficient to induce thermotolerance in postimplantation mammalian embryos, we used a transgenic mouse in which the normally strictly inducible Hsp70 is constitutively expressed in the embryo under the control of a beta-actin promoter. Day 8.0 mouse embryos heterozygous for the Hsp70 transgene were not protected from the embryotoxic effects of hyperthermia (43 degrees C); however, homozygous embryos, expressing approximately twice as much Hsp70 as heterozygous embryos, were partially protected (increased embryo viability) from the embryolethal effects of hyperthermia. Although the viability of transgenic embryos was significantly increased compared with that of nontransgenic embryos, this protection did not extend to embryo growth and development. To determine whether the failure to achieve a more robust protection was related to the expression of insufficient Hsp70 in transgenic embryos, we undertook experiments to determine whether the level of Hsp70 correlated with the level of thermotolerance induced by various lengths of a 41 degrees C heat shock. A 41 degrees C, 5-minute heat shock failed to induce Hsp70 or thermotolerance, a 41 degrees C, 15-minute heat shock induced Hsp70 and a significant level of thermotolerance, while a 41 degrees C, 60-minute heat shock induced an even higher level of Hsp70 as well as a higher level of thermotolerance. Quantitation of Hsp70 levels indicated that thermotolerance was associated with levels of Hsp70 of 820 pg/microg embryo protein or greater. Subsequent quantitation of the amount of Hsp70 expressed in homozygous transgenic embryos indicated a level of 577 pg/microg embryo protein, that is, a level below that associated with induced thermotolerance. Overall, results presented indicate that Hsp70 does play a direct role in the induction of thermotolerance in postimplantation mouse embryos; however, the level of thermotolerance is dependent on the level of Hsp70 expressed. (+info)Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. (2/735)
Age of onset (AO) of Huntington disease (HD) is known to be correlated with the length of an expanded CAG repeat in the HD gene. Apolipoprotein E (APOE) genotype, in turn, is known to influence AO in Alzheimer disease, rendering the APOE gene a likely candidate to affect AO in other neurological diseases too. We therefore determined APOE genotype and normal CAG repeat length in the HD gene for 138 HD patients who were previously analysed with respect to CAG repeat length. Genotyping for APOE was performed blind to clinical information. In addition to highlighting the effect of the normal repeat length upon AO in maternally inherited HD and in male patients, we show that the APOE epsilon2epsilon3 genotype is associated with significantly earlier AO in males than in females. Such a sex difference in AO was not apparent for any of the other APOE genotypes. Our findings suggest that subtle differences in the course of the neurodegeneration in HD may allow interacting genes to exert gender specific effects upon AO. (+info)Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer. (3/735)
Adenovirus-mediated transduction of the herpes simplex thymidine kinase gene (HSV-tk) in conjunction with ganciclovir (GCV) has been shown to result in significant growth suppression and to enhance survival in a model of mouse prostate cancer. However, this therapeutic activity is not sustained, because in most cases tumors eventually regrow and ultimately cause the death of the host. Androgen ablation, an inducer of apoptosis in prostate cells which is used widely as palliative therapy in patients with prostate cancer, was combined with HSV-tk plus GCV using an androgen-sensitive mouse prostate cancer cell line. The combination of castration and HSV-tk plus GCV led to markedly enhanced tumor growth suppression in both subcutaneous and orthotopic models compared with either treatment alone and resulted in an enhanced survival in which combination-treated animals lived twice as long as controls in the subcutaneous model and over 50% longer than controls in the orthotopic model. Further analysis of apoptotic activity demonstrated high levels of apoptosis only in combined androgen ablation and HSV-tk plus GCV-treated tumors after 14 days of growth in an androgen-depleted environment and 8 days after HSV-tk plus GCV therapy. At this time, the apoptotic index, but not the percent of necrotic tissue, was significantly higher for combination therapy-treated tumors relative to control-treated tumors or either treatment alone. These data indicate that the therapeutic effects of androgen ablation and HSV-tk plus GCV are cooperative and that increased apoptosis may, in part, underlie these activities. (+info)Additive effects of human recombinant interleukin-11 and granulocyte colony-stimulating factor in experimental gram-negative sepsis. (4/735)
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used to promote granulocyte recovery from a variety of pathologic states. Recombinant human interleukin-11 (rhIL-11) has recently become available clinically as a platelet restorative agent after myelosuppressive chemotherapy. Preclinical data has shown that rhIL-11 limits mucosal injury after chemotherapy and attenuates the proinflammatory cytokine response. The potential efficacy of combination therapy with recombinant human forms of rhIL-11 and rhG-CSF was studied in a neutropenic rat model of Pseudomonas aeruginosa sepsis. At the onset of neutropenia, animals were randomly assigned to receive either rhG-CSF at a dose of 200 micrograms/kg subcutaneously every 24 hours for 7 days; rhIL-11 at 200 micrograms/kg subcutaneously every 24 hours for 7 days; the combination of both rhG-CSF and rhIL-11; or saline control. Animals were orally colonized with Pseudomonas aeruginosa 12.4.4 and then given a myelosuppressive dose of cyclophosphamide. rhG-CSF resulted in a slight increase in absolute neutrophil counts (ANC), but did not provide a survival advantage (0 of 12, 0% survival) compared with the placebo group (1 of 12, 8% survival). rhIL-11 was partially protective (4 of 10, 40% survival); the combination of rhG-CSF and rhIL-11 resulted in a survival rate of 80% (16 of 20; P <.001). rhIL-11 alone or in combination with rhG-CSF resulted in preservation of gastrointestinal mucosal integrity (P <.001), lower circulating endotoxin levels (P <.01), and reduced quantitative levels of P. aeruginosa in quantitative organ cultures. These results indicate that the combination of rhIL-11 and rhG-CSF is additive as a treatment strategy in the prevention and treatment of experimental Gram-negative sepsis in immunocompromised animals. This combination may prove to be efficacious in the prevention of severe sepsis in neutropenic patients. (+info)Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. (5/735)
The hepatic leukemia factor (HLF) gene codes for a basic region-leucine zipper (bZIP) protein that is disrupted by chromosomal translocations in a subset of pediatric acute lymphoblastic leukemias. HLF undergoes fusions with the E2A gene, resulting in chimeric E2a-Hlf proteins containing the E2a transactivation domains and the Hlf bZIP DNA binding and dimerization motifs. To investigate the in vivo role of this chimeric bZIP protein in oncogenic transformation, its expression was directed to the lymphoid compartments of transgenic mice. Within the thymus, E2a-Hlf induced profound hypoplasia, premature involution, and progressive accumulation of a T-lineage precursor population arrested at an early stage of maturation. In the spleen, mature T cells were present but in reduced numbers, and they lacked expression of the transgene, suggesting further that E2a-Hlf expression was incompatible with T-cell differentiation. In contrast, mature splenic B cells expressed E2a-Hlf but at lower levels and without apparent adverse or beneficial effects on their survival. Approximately 60% of E2A-HLF mice developed lymphoid malignancies with a mean latency of 10 months. Tumors were monoclonal, consistent with a requirement for secondary genetic events, and displayed phenotypes of either mid-thymocytes or, rarely, B-cell progenitors. We conclude that E2a-Hlf disrupts the differentiation of T-lymphoid progenitors in vivo, leading to profound postnatal thymic depletion and rendering B- and T-cell progenitors susceptible to malignant transformation. (+info)Therapy of severe diabetic ketoacidosis. Zero-mortality under very-low-dose insulin application. (6/735)
OBJECTIVE: Despite modern concepts in therapy by low-dose insulin application and better care in intensive care units (ICUs), there still is a mortality of 5-10% for severe diabetic ketoacidosis (DKA). The aim of this study was to develop a therapy concept to reduce complications and mortality in DKA. RESEARCH DESIGN AND METHODS: From 1986 to 1997, 114 consecutive patients (mean [range]; age 34 [11-74] years) with type 1 diabetes suffering from severe DKA were treated on ICUs and investigated in a retrospective and prospective study. The following are the criteria for admission onto ICUs: < 7.20 pH level, > 300 mg/dl blood glucose, less than -12 mmol/l base excess, or < 300 mg/dl blood glucose plus severe symptoms (i.e., coma). We treated patients according to the following concepts: very-low-dose insulin application by a basal insulin infusion of 1 U/h (0.5-4.0 U/h i.v.), maximal decrease of blood glucose level by 50 mg. dl-1. h-1, slow-motion reequilibration by fluid substitution of 1,000 ml/h (Ringer-Lactate, NaCl 0.9% or half-electrolyte fluids) in the first 4 h, potassium replacement and heparin (500-1,000 U/h i.v.). RESULTS: When patients were admitted to ICU, we found the following parameters: mean (range); 609.0 (86.0-1,428.0) mg/dl blood glucose level; 7.13 (6.53-7.36) pH level; and -19.7 (-41.2 to -7.0) mmol/l base excess. After 12 h of treatment, we reached the following parameters: mean values; 251 mg/dl blood glucose level, 7.31 pH level, and -9.37 mmol/l base excess level. All patients survived without any lasting deficiencies or fatal complications. CONCLUSIONS: Very-low-dose insulin application and slow-motion reequilibration plus monitored substitution of electrolytes are the basic strategies in the treatment of severe DKA. In our view, small doses of infused insulin are the main reason for the safe results of this therapy program. (+info)p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. (7/735)
The commitment of cells to replicate and divide correlates with the activation of cyclin-dependent kinases and the inactivation of Rb, the product of the retinoblastoma tumor suppressor gene. Rb is a target of the cyclin-dependent kinases and, when phosphorylated, is inactivated. Biochemical studies exploring the nature of the relationship between cyclin-dependent kinase inhibitors and Rb have supported the hypothesis that these proteins are on a linear pathway regulating commitment. We have been able to study this relationship by genetic means by examining the phenotype of Rb+/-p27-/- mice. Tumors arise from the intermediate lobe cells of the pituitary gland in p27-/- mice, as well as in Rb+/- mice after loss of the remaining wild-type allele of Rb. Using these mouse models, we examined the genetic interaction between Rb and p27. We found that the development of pituitary tumors in Rb+/- mice correlated with a reduction in p27 mRNA and protein expression. To determine whether the loss of p27 was an indirect consequence of tumor formation or a contributing factor to the development of this tumor, we analyzed the phenotype of Rb+/-p27-/- mice. We found that these mice developed pituitary adenocarcinoma with loss of the remaining wild-type allele of Rb and a high-grade thyroid C cell carcinoma that was more aggressive than the disease in either Rb+/- or p27-/- mice. Importantly, we detected both pituitary and thyroid tumors earlier in the Rb+/-p27-/- mice. We therefore propose that Rb and p27 cooperate to suppress tumor development by integrating different regulatory signals. (+info)Functional recovery after coronary artery bypass grafting in patients with severe left ventricular dysfunction and preserved myocardial viability in the left anterior descending arterial territory as assessed by thallium-201 myocardial perfusion imaging. (8/735)
To evaluate the functional recovery after coronary bypass surgery in patients with severe left ventricular (LV) dysfunction (ejection fraction (EF) < or = 35%), 100 consecutive patients with viable myocardium in the territory supplied by the left anterior descending artery (LAD) underwent coronary bypass grafting. In addition, cardiac catheterization and single-photon emission computed tomography (SPECT) perfusion imaging with thallium-201 were repeated 1-year postoperatively. Although 12 patients with severe LV dysfunction were preoperatively in a worse New York Heart Association functional class (3.1+/-0.7 vs 2.4+/-0.8; p<0.01), had a higher incidence of heart failure (10/12 vs 14/88; p<0.001) and had a worse LVEF (29+/-5 vs 61+/-14%; p<0.001) compared with 88 patients without severe LV dysfunction, the operative mortality was similar in the 2 groups (1/12 vs 2/88; p=NS). The postoperative NYHA functional class in the patients with severe LV dysfunction was similar to that in the patients without such dysfunction (1.6+/-0.7 vs 1.3+/-0.6; p=NS). In addition, the 1-year postoperative study revealed a significant improvement in the thallium defect score in both the LAD territory (1.7+/-1.2 to 0.7+/-1.0, p=0.01) and all the territories (5.2+/-2.2 to 3.2+/-1.9, p=0.002) in patients with severe LV dysfunction, whereas no improvement in defect score was found in either of these territories in those without severe LV dysfunction (LAD: 0.6+/-1.4 to 0.4+/-1.2, p=NS; All: 1.9+/-2.2 to 1.8+/-2.0, p=NS). Furthermore, a marked 1-year postoperative improvement (15-24%; 95% confidence interval) in LVEF (29+/-5 to 48+/-10%, p<0.001) was demonstrated in patients with severe LV dysfunction, but not in those without such dysfunction (60+/-13 to 61+/-11%, p=NS). These results indicate that myocardial viability in the LAD territory, as demonstrated by thallium-201 SPECT perfusion imaging, predicts a significant improvement in functional class and LVEF of at least 10% or more after coronary artery bypass grafting in patients with severe LV dysfunction. (+info)
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Hand transplantation
Survival rates[edit]. Although the one-year survival rate of transplanted hands has been excellent at institutions that are ...
Honey bee
Winter survival[edit]. In cold climates, honey bees stop flying when the temperature drops below about 10 °C (50 °F) and crowd ...
Autophagy
Tumor cell survival[edit]. Alternatively, autophagy has also been shown to play a huge role in tumor cell survival. In ... A high rate above the survival threshold may kill cancer cells with a high apoptotic threshold.[86][87] This technique can be ... There is evidence that emphasizes the role of autophagy both as a tumor suppressor as well as a factor in tumor cell survival. ... These stresses activate autophagy in order to recycle ATP and maintain survival of the cancerous cells.[86] Autophagy has been ...
Non-small-cell lung carcinoma
Five-year survival rates[edit]. The survival rates for stages I through IV decrease significantly due to the advancement of the ... may increase both overall survival and progression free survival.[50] In 2015 the US FDA approved the anti-PD-1 agent nivolumab ... "Non-Small Cell Lung Cancer Survival Rates, by Stage". www.cancer.org. Retrieved 4 December 2017.. ... For stage I, the five-year survival rate is 47%, stage II is 30%, stage III is 10%, and stage IV is 1%.[33] ...
San Francisco Zoo
Species survival projects[edit]. The San Francisco Zoo participates in Species Survival Plans, conservation programs sponsored ... "Species Survival Plan Program". Association of Zoos and Aquariums. 29 April 2008. Archived from the original on 2008-02-29. ...
Middle Ages
There are survivals from the large brooches in fibula or penannular form that were a key piece of personal adornment for elites ... Byzantine survival. Main articles: Byzantine Empire under the Justinian dynasty and Byzantine Empire under the Heraclian ...
Menopause
"Survival of the fittest" hypothesis[edit]. This hypothesis suggests that younger mothers and offspring under their care will ... Humans, more so than other primates, rely on food sharing for survival,[150] so the large survivorship reduction values could ... That a mother's presence could aid in the survival of a developing child, while an unidentified father's absence might not have ... That would be counterproductive to the supposed adaptation of getting male support as a fertile female and ruin survival for ...
Traditional English pronunciation of Latin
Illustrative survivals[edit]. The traditional pronunciation survives in academic and general English vocabulary: *In academic ...
BRCA mutation
Survival impact[edit]. Among women who die before age 70.... 72 / 100. ... Having this surgery at a very young age provides little or no additional survival advantage, but it does increase the adverse ... They may choose to focus on total cancer prevention, psychological benefits, current quality of life, or overall survival. The ... "Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1". Lancet. 351 (9099): 316-321. ...
Wilderness medicine (practice)
Clothing selection for wilderness survival. *Land navigation. Safety, rescue and evacuation[edit]. *Search and rescue theory ...
Ephrin A5
Reverse signaling in growth cone survival[edit]. "Reverse" signaling is one unique property of ephrin ligands that allows for ... This finding that ephrin A5 promotes growth cone survival that is opposite of EphA signaling and mediated directly by ephrin A5 ... 1 Reverse signaling in growth cone survival *1.1 Formation of the retinotopic map ...
Rock dove
Survival[edit]. Predators[edit]. With only their flying abilities protecting them from predation, rock pigeons are a favourite ...
Common kingfisher
Survival[edit]. The early days for fledged juveniles are more hazardous; during its first dives into the water, about four days ... "Survival and threats". Kingfisher. Royal Society for the Protection of Birds. Retrieved 23 August 2008.. ...
James Wesley Rawles
Tools For Survival[edit]. His Tools For Survival: What You Need to Survive When You're on Your Own (2014) is another non- ... Initially titled: Patriots: Surviving the Coming Collapse, and later re-titled: Patriots: A Novel of Survival in the Coming ... Patriots: A Novel of Survival in the Coming Collapse[edit]. Main article: Patriots Novels Series ... Patriots: A Novel of Survival in the Coming Collapse, Ulysses Press, Berkeley, California, ISBN 978-1-56975-599-0 (April 2009 ...
Mircea Eliade
Religious survivals in the secular world[edit]. Eliade says that secular man cannot escape his bondage to religious thought. By ...
Mustard procedure
Long-term survival[edit]. The Mustard procedure improved an 80% mortality rate in the first year of life to an 80% survival at ...
Hazard ratio
In the Cox-model, this can be shown to translate to the following relationship between group survival functions: S. 1. (. t. ) ... In survival analysis, the hazard ratio (HR) is the ratio of the hazard rates corresponding to the conditions described by two ... The hazard ratio and survival[edit]. Hazard ratios are often treated as a ratio of death probabilities.[2] For example, a ... Cantor, Alan (2003). Sas Survival Analysis Techniques for Medical Research. SAS Institute. pp. 111-150. ISBN 9781590471357.. ...
Black-billed magpie
Survival[edit]. The black-billed magpie often forms loose flocks outside of the breeding season. Dominance hierarchies may ...
Eurasian tree sparrow
... suggesting that decreases in productivity were not responsible for the decline and that survival was the critical factor.[76] ... "The effect of egg size on growth and survival of the Tree Sparrow Passer montanus nestlings". Acta Ornithologica. 39 (2): 121- ...
Canada goose
Survival[edit]. The lifespan in the wild of geese that survive to adulthood ranges from 10 to 24 years.[14] The British ... Stolley, Doris; Bissonette, John; Kadlec, John (1999). "Effects of saline environments on the survival of wild goslings (Branta ...
Ashtabula River railroad disaster
2.2 Initial collapse and survival of the "Socrates". *2.3 Collapse of the remaining bridge ...
Unihemispheric slow-wave sleep
Survival of the fittest adaptation[edit]. The evolution of both cetaceans and birds may have involved some mechanisms for the ...
Naturally occurring phenols
Role in survival[edit]. Phenolic compounds can act as protective agents, inhibitors, natural animal toxicants and pesticides ...
Periodical cicadas
... overall survival mechanism was simply to overwhelm predators by their sheer numbers, ensuring the survival of most of the ... Their mass emergence is a survival trait called predator satiation: for the first week after emergence, the periodical cicadas ...
Harbor seal
Annual survival rates were calculated at 0.91 for adult males,[9] and 0.902 for adult females.[15] Maximum age for females was ... 5 Behavior, survival, and reproduction *5.1 Harbor seals in North America *5.1.1 Pacific Coast ... "Survival probabilities and movements of harbor seals in central California". Marine Mammal Science. 33: 154-171. doi:10.1111/ ...
Uruguayan Air Force Flight 571
"True Survival Stories: Miracle In The Andes - Survival Life". 12 October 2016. Archived from the original on 14 June 2018.. ... "Survival". Archived from the original on September 11, 2018.. *^ "Sitio Oficial del accidente de los Andes - Historia". Viven. ... Read, Piers Paul (2005). Alive: Sixteen Men, Seventy-two Days, and Insurmountable Odds - The Classic Adventure of Survival in ... Passenger survival[edit]. Of the 45 people on the aircraft, three passengers and two crew members in the tail section were ...
Jane Jacobs
Systems of Survival[edit]. Main article: Systems of Survival. Systems of Survival: A Dialogue on the Moral Foundations of ... Systems of Survival: A Dialogue on the Moral Foundations of Commerce and Politics (1992) ISBN 0-679-74816-4 ... "double nature of fitness for survival" (traits to avoid destroying one's own habitat as well as success in competition to feed ...
Sora (bird)
Survival[edit]. Few data are available on the survival of soras. Radio-marked soras in Arizona had a nonbreeding survival ... The authors suggest the low survival rate may be due to increased mortality of radio-marked birds.[27] Likely causes of ... "Nesting success and survival of Virginia rails and soras" (PDF). The Wilson Bulletin. 106 (3): 466-473. ...
Nerve growth factor
... while NGF treatment of these same neurons results in survival and axonal growth. Survival and PCD mechanisms are mediated ... Neuron survival[edit]. Binding interaction between NGF and the TrkA receptor facilitates receptor dimerization and tyrosine ... Lee R, Kermani P, Teng KK, Hempstead BL (Nov 2001). "Regulation of cell survival by secreted proneurotrophins". Science. 294 ( ... As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve ...
Medical emergency
The chain of survival[edit]. The principles of the chain of survival apply to medical emergencies where the patient is not ...
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Survival kit - Wikipedia
Mini survival kits[edit]. Main article: Mini survival kit. "Mini survival kits" or "Altoids tin" survival kits are small kits ... Bug-out bags / Survival Backpacks[edit]. Main article: Bug-out bag. The term "survival kit" may also refer to the larger, ... A survival kit is a package of basic tools and supplies prepared as an aid to survival in an emergency. Civil and military ... Lightweight survival kits are generally seen as a backup means of survival; however, these can kits can be extensive, and have ...
Survival (Doctor Who) - Wikipedia
"Doctor Who Classic Episode Guide - Survival". BBC. Retrieved 15 August 2016.. *^ "Doctor Who - Survival Original TV Soundtrack" ... Doctor Who Locations - Survival. Target novelisation[edit]. *Survival title listing at the Internet Speculative Fiction ... Although Survival was the last Doctor Who serial of the original series to be transmitted, it was not the last to have been ... Survival is the final serial of the 26th season and also the final story of the original 26-year run of the British science ...
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Personal Survival Kits Increase Odds
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Cancer survival rates are up
Cancer survival rates are at the highest ever with more than 2,000 more people recovering from the disease this year able to ... Cancer survival rates are at the highest ever with more than 2,000 more people recovering from the disease this year able to ... According to figures published by the Office for National Statistics, areas with statistically low survival rates, such as ... improving survival and quality of life for all those affected by cancer as the latest figures demonstrate. We are determined to ...
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Eye Cancer Survival Rates
Find the survival rates for eye cancer here. ... Survival rates of eye cancer are based on outcomes of people ... Eye Cancer Survival Rates. Survival rates can give you an idea of what percentage of people with the same type and stage of ... What is a 5-year relative survival rate?. A relative survival rate compares people with the same type and stage of cancer to ... 5-year relative survival rates for eye melanoma. (Based on people diagnosed with melanoma of the eye between 2008 and 2014.) ...
Outdoor Survival - Active Living
Well cover survival psychology, pre-planning and emergency response, a review of environmental medical emergencies, clothing ... Includes: certified instructor, use of survival equipment for course activities, course manual, Personal Emergency Kit (take ... Well cover survival psychology, pre-planning and emergency response, a review of environmental medical emergencies, clothing ... Includes: certified instructor, use of survival equipment for course activities, course manual, Personal Emergency Kit (take ...
Survival of the Hippest
Few TV shows have captured the imagination of viewers as much as Survivor, the hit show that pits 16 contestants against nature-and each other-on a tropical isle. The show divides the contestants into tribes, which compete in contests of skill. Each week the losing tribe votes to expel a member from the island, until only one remains-the hearty individual who has bested personal politicking, petty bickering, and the occasional meal of grilled rat to reign as sole survivor. But why not populate the island with computer-industry heavyweights? After all, whos more familiar with personal politicking, petty bickering, and vermin than the titans of Silicon Valley?-Philip Michaels. APPLE TRIBE Steve Jobs, Apple CEO ...
Cancer survival rates - NHS
The EUROCARE-4 study looked at cancer cure and survival rates between ... Widespread media coverage has been given to a large study on cancer survival across Europe. ... This method of comparing observed survival with expected survival is often used in registry studies to compare survival across ... Survival among people with cancer relative to the expected survival of people from the general population of the same age and ...
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Smoking, drinking imperil lymphoma survival | Reuters
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Dual Survival, Season 9 on iTunes
The worlds toughest survival experts will forge new partnerships to take on some of the most challenging wilderness ... environments on an all-new season of DUAL SURVIVAL. Venturing into the wilderness are NAKED AND AFRAID champions EJ Snyder and ... The worlds toughest survival experts will forge new partnerships to take on some of the most challenging wilderness ... The worlds toughest survival experts will forge new partnerships to take on some of the most challenging wilderness ...
What makes the perfect survival movie?
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Survival Rates for Prostate Cancer
Find the survival rates for prostate cancer here. ... Survival rates of prostate cancer are based on outcomes of ... Survival Rates for Prostate Cancer. Survival rates can give you an idea of what percentage of people with the same type and ... What is a 5-year relative survival rate?. A relative survival rate compares men with the same type and stage of prostate cancer ... Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a ...
Survival in the Great Rift
Brain Cancer Incidence and Survival
Learn about the incidence of brain cancer and survival rates during a period encompassing the introduction of CT and MR imaging ... However, by excluding benign CNS tumors, which show better survival rates, SEER data underestimate survival rates for patients ... The advantage of using SEER data for calculating patient survival rate is that it is a population-based estimate and it ... As reported earlier, the 5-year relative survival rate differs only minimally by sex, race, and place of residence. As in ...
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Kaplan-Meier survival curve. We look at the data using a Kaplan-Meier survival curve. Suppose that the survival times, ... is the largest survival time less than or equal to t and is the number of subjects alive just before time (the ith ordered ... That the survival times are ordinal or continuous.. *That the risk of an event in one group relative to the other does not ... To compare two survival curves produced from two groups A and B we use the rather curiously named log rank test,1 so called ...
NCDB Survival Reports
5-year observed survival rates for all cancer sites. ... NCDB Survival Reports allow CoC-accredited cancer programs ... Survival Report User Guide Survival is a key factor for any cancer patient and the cancer programs that treat them. ... Users who log into the new survival tools application will be asked to agree to not publicly report their survival rates before ... Increasingly, national groups are asking for the reporting of long-term survival information. While survival rates are ...
20172016Asshole Survival Guide2021FittestIncidenceGuideProgression-free surRatesImproves survivalContentWilderness survivalHigh quality survivalRelative survival rate1981Critic ReviewsSignificantlyCurvesReutersDual SurvivalImprove survivalOutdoor SurvivalNewsAuthorClimateTimeToughestAnalysisResearchersEstimationChemotherapyPatientsRateCardiovascular diseaseStrokeEpisodesMicroscopicTreatmentRescuePracticeEstimatesProspectsDataSuggestsLinkStoriesUnderstood
20171
- AudioSolutionz, a division of audio conference and corporate education leader ProEdTech, will host the live webinar " Outlook Survival Skills " with industry veteran Karla Brandau, CSPPS on Thursday, August 24, 2017 at 1:00 pm ET. (prweb.com)
20161
- WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Higher doses of the cholesterol -lowering drugs known as statins appear to boost survival slightly for certain people, a large new study reports. (medicinenet.com)
Asshole Survival Guide2
- In The Asshole Survival Guide, Stanford professor Robert Sutton offers practical advice on identifying and tackling any kind of asshole -- based on research into groups from uncivil civil servants to French bus drivers, and 8,000 emails that he has received on asshole behaviour. (penguin.co.uk)
- With cutting-edge research and real-life examples that are thought-provoking and often hilarious , The Asshole Survival Guide is an indispensable resource. (penguin.co.uk)
20211
- Feb. 1, 2021 -- Lung cancer experts have been impressed by long-term study results that continue to show the combination of immunotherapy and chemotherapy doubles survival compared with chemotherapy alone. (webmd.com)
Fittest3
- Paterson denies anything amiss has taken place, falling back on his "survival of the fittest" mantras and his self-defence classes. (wikipedia.org)
- No forum topics for Cubivore: Survival of the Fittest yet. (gamespot.com)
- For example, Charles Darwin's theory of natural selection incorporates the concept of the survival of the fittest in the struggle for existence. (wikipedia.org)
Incidence4
- Trends in Brain Cancer Incidence and Survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. (medscape.com)
- USCS includes incidence and survival data from CDC's National Program of Cancer Registries (NPCR) and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program and mortality data from the National Vital Statistics System ( 3 ). (cdc.gov)
- Surveillance of cancer incidence and survival are essential for identifying population groups with high cancer incidence rates and low cancer survival rates as well as for estimating the number of cancer survivors, which was 13.7 million in 2012 ( 1 ). (cdc.gov)
- While stroke incidence didn't differ among neighborhoods, stroke survival was far better for seniors living in 'cohesive' neighborhoods, regardless of their gender. (prnewswire.com)
Guide4
- We hope that this 'Parent Survival Guide' provides you with the information you need to assist your student in choosing their home for the next four years. (gatech.edu)
- To submit information to Survival Guide, fax it to 245-8618 or mail it to Survival Guide, c/o Daily Press, 7505 Warwick Blvd., Newport News 23607. (dailypress.com)
- There is also a wide body of educational literature, sometimes referred to as a survival guide, offering advice on survival skills in various dangerous situations such as getting lost without food or water, being attacked, or being in a natural disaster. (wikipedia.org)
- Amazon.com, The Outdoor Survival Handbook: A Guide To The Resources. (wikipedia.org)
Progression-free sur5
- Postoperative platinum based chemotherapy is associated with a small benefit in progression-free survival and overall survival irrespective of radiotherapy treatment. (cochrane.org)
- The HR for progression-free survival is 0.75 (0.64 to 0.89). (cochrane.org)
- A similar pattern was seen for progression-free survival Patients receiving the combination had a median 9.0 months progression-free survival, versus 4.9 months with chemotherapy alone). (webmd.com)
- Previous results from study had already demonstrated that, after a median follow-up of 10.5 months, adding pembrolizumab to chemotherapy significantly improves both overall survival and progression-free survival compared with chemotherapy alone. (webmd.com)
- The latest results show that the combination "continued to provide overall survival and progression-free survival benefit" in extended follow-up, said study presenter Jhanelle Elaine Gray, MD, chair, Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, Florida. (webmd.com)
Rates25
- This shows that chemotherapy reduces the risk of recurrent disease, lengthens the duration women have before a metastasis is diagnosed and improves survival rates. (cochrane.org)
- C ancer survival rates are at the highest ever with more than 2,000 more people recovering from the disease this year able to enjoy Christmas with their families. (telegraph.co.uk)
- According to figures published by the Office for National Statistics, areas with statistically low survival rates, such as Barking in London and Medway in Kent, are now closing in or have caught up with the average recovery rates. (telegraph.co.uk)
- Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed. (cancer.org)
- Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they can't predict what will happen in any particular person's case. (cancer.org)
- The SEER database tracks 5-year relative survival rates for eye cancer (melanoma) in the United States, based on how far the cancer has spread. (cancer.org)
- Survival rates are grouped based on how far the cancer has spread. (cancer.org)
- Factors other than the stage of the cancer can also affect survival rates. (cancer.org)
- The EUROCARE-4 study looked at cancer cure and survival rates between 1995 and 2004. (www.nhs.uk)
- Further study would be needed to determine the contribution of each of these factors and how to improve survival rates. (www.nhs.uk)
- Additionally, these figures are for cancers diagnosed more than 10 years ago, and survival rates may have improved since then. (www.nhs.uk)
- This registry-based cohort study, called the EUROCARE study, looked at cure and survival rates of people diagnosed with cancer in Europe. (www.nhs.uk)
- The EUROCARE study began in 1990, and papers have already been published on survival rates for people diagnosed with cancer between 1978 and 1985, 1985 and 1989, and 1990 to 1994 (EUROCARE studies one to three). (www.nhs.uk)
- The researchers looked at cancer survival rates for people diagnosed with cancer between 1995 and 1999, but also looked at survival in cases diagnosed from 1978 to 2002 using data they had collected in all the EUROCARE studies. (www.nhs.uk)
- Talamini, at the National Cancer Institute in Aviano, Italy, and colleagues evaluated the survival rates of 268 NHL patients seen there over a 20 year period and who were followed for an average of 5 years. (reuters.com)
- The National Cancer Database (NCDB) Survival Reports are provided to allow Commission on Cancer (CoC)-accredited cancer programs access to unadjusted American Joint Committee on Cancer (AJCC) stage-stratified, five-year observed survival rates for all cancer sites. (facs.org)
- While survival rates are intuitively a key factor in anticipating the consequences of a cancer diagnosis and treatment, they may or may not be a clear reflection of the quality of care provided by a physician or cancer program. (facs.org)
- Users who log into the new survival tools application will be asked to agree to not publicly report their survival rates before they are allowed to generate a survival report. (facs.org)
- Women from deprived areas have poorer survival rates from breast cancer than women from more affluent areas. (www.nhs.uk)
- The 5-year relative survival rates were calculated for cases diagnosed during 2003-2010 with follow-up through 2010 ( 4 ). (cdc.gov)
- Seniors living in closely-knit, supportive neighborhoods have significantly better stroke survival rates than others, regardless of other health or socioeconomic factors. (prnewswire.com)
- With the increased interest in complementary therapies, a team of scientists recently explored their use in cancer patients, and how they impacted both adherence to treatments and survival rates. (medicalnewstoday.com)
- Though some complementary medicines seem to improve the lives of individuals with cancer - by increasing the level of hope and improving self-rated life satisfaction - little is known about how they impact survival rates. (medicalnewstoday.com)
- They wanted to understand how the use of complementary medicine in cancer influenced adherence to medical treatments, and how that impacted survival rates. (medicalnewstoday.com)
- Survival rates are important for prognosis, but because the rate is based on the population as a whole, an individual prognosis may be different depending on newer treatments since the last statistical analysis as well as the overall general health of the patient. (wikipedia.org)
Improves survival1
- The next step will be to see if smoking cessation or reducing alcohol consumption improves survival or treatment responses in these patients. (reuters.com)
Content2
- The Emergency Survival Kit , like all of all of our apps, enables you to find and enjoy all of the great content on wikiHow in many ways. (wikihow.com)
- The content will also include parametric and semiparametric models which are very common in survival analysis. (warwick.ac.uk)
Wilderness survival5
- Instructions on first aid, vehicle problems, bad weather and wilderness survival. (wikihow.com)
- r/survival is a forum for sharing and discussion of the topic of wilderness survival and not an authoritative source of information. (reddit.com)
- What is Wilderness Survival ? (reddit.com)
- r/survival defines Wilderness Survival as the philosophies, knowledge, techniques, and actions applied in a Wilderness environment, in a short-term survival scenario, which serve to increase the likelihood of survival of the individual or group. (reddit.com)
- Keep all posts on the topic of Wilderness Survival (see definition above). (reddit.com)
High quality survival2
- The Pocket Survival Pak is an affordable, high quality survival product that really can save your life. (prweb.com)
- High quality Survival inspired Photographic Prints by independent artists and designers from around the world. (redbubble.com)
Relative survival rate4
- What is a 5-year relative survival rate? (cancer.org)
- A relative survival rate compares people with the same type and stage of cancer to people in the overall population. (cancer.org)
- For example, if the 5-year relative survival rate for a specific stage of eye cancer is 80%, it means that people who have that cancer are, on average, about 80% as likely as people who don't have that cancer to live for at least 5 years after being diagnosed. (cancer.org)
- For the first time, a subset of the USCS dataset includes the 5-year relative survival rate, defined as the proportion of persons surviving ≥5 years after cancer diagnosis compared with the proportion of survivors expected in a set of comparable cancer-free persons. (cdc.gov)
19811
- Journey for Survival is a 1981 American short documentary film directed by Dick Young. (wikipedia.org)
Critic Reviews1
- There are no critic reviews yet for The Survival of Dana . (rottentomatoes.com)
Significantly2
- Survival odds increase significantly when packing a personal survival kit. (prweb.com)
- Complete with a rescue whistle that exceeds US Coast Guard and SOLAS specifications, current military issue Firestarter, Rescue Signal Mirror and a Survival Compass, this kit significantly increases your odds of surviving a crisis. (prweb.com)
Curves1
- To compare two survival curves produced from two groups A and B we use the rather curiously named log rank test,1 so called because it can be shown to be related to a test that uses the logarithms of the ranks of the data. (bmj.com)
Reuters1
- NEW YORK (Reuters Health) - Smoking and moderate-to-high alcohol consumption negatively affect the survival of people with non-Hodgkin lymphoma, dubbed NHL, a European study shows. (reuters.com)
Dual Survival1
- The world's toughest survival experts will forge new partnerships to take on some of the most challenging wilderness environments on an all-new season of DUAL SURVIVAL. (apple.com)
Improve survival1
- In any case, Thomson said, healthy diets do seem to be important to reduce cancer risk and to improve survival after cancer. (reuters.com)
Outdoor Survival1
- The Outdoor Survival Handbook is a 1992 survival book by Ray Mears. (wikipedia.org)
News1
- BBC News Online consulted three financial experts for their top survival tips. (bbc.co.uk)
Author4
- In Pedagogy of Survival , the author uses the narratives of ordinary people to highlight extraordinary lessons of perseverance. (peterlang.com)
- The study showed that people over 75 also have a survival benefit with high doses compared to moderate doses, said study author Dr. Fatima Rodriguez. (medicinenet.com)
- Jonathan Maberry, New York Times bestselling author of ROT & RUIN and V-WARS" "Set in a gritty post-apocalyptic world, SURVIVAL COLONY 9 is both an adventure and an exploration of what it means to be human. (worldcat.org)
- The author said survival films "identify and isolate a microcosm of society", such as the surviving group from the plane crash in The Flight of the Phoenix (1965) or those on the overturned ocean liner in The Poseidon Adventure (1972). (wikipedia.org)
Climate4
- Civilians such as forestry workers, surveyors, or bush pilots, who work in remote locations or in regions with extreme climate conditions may also be equipped with survival kits. (wikipedia.org)
- Climate change, in confronting us with its ominous truths, offers us both opportunities and challenges: the opportunity to recreate ourselves, the challenge to evolve beyond our instinctual predilections in reconsidering and redressing how we live with each other and with the earth we inhabit, and, ultimately, the opportunity and the challenge to reimagine and reinvent our understanding of how we pursue survival. (cmaj.ca)
- Combine that almost familiar-sounding horror with increasingly extreme weather all over the globe, geopolitical instability because of climate refugees and food scarcity, disappearing shorelines, and so much more, and you can see why the conversation about climate is starting to shift from slowdown to survival. (wired.com)
- Dr Dubey added: "Looking at the history of species survival will help us to predict which ones could be better able to deal with current climate change and to better predict the threat status of species on the red list of the International Union for Conservation of Nature (IUCN). (biomedcentral.com)
Time12
- Most survival kits include sustenance for short periods of time, to be used and replenished before contents spoil. (wikipedia.org)
- Survival analysis is a statistical methodology to study the occurrence of an event over time. (amazonaws.com)
- A graphical representation of typical survival data is depicted in Figure 1, which shows study recruitment over time. (amazonaws.com)
- Survival analysis is concerned with studying the time between entry to a study and a subsequent event. (bmj.com)
- Originally the analysis was concerned with time from treatment until death, hence the name, but survival analysis is applicable to many areas as well as mortality. (bmj.com)
- Order the survival time by increasing duration starting with the shortest one. (bmj.com)
- The survival curve is unchanged at the time of a censored observation, but at the next event after the censored observation the number of people "at risk" is reduced by the number censored between the two events. (bmj.com)
- We consider the impact of history on the survival of a monopolist selling single units in discrete time periods, whose quality is learned slowly. (repec.org)
- There are no featured reviews for The Survival of Dana at this time. (rottentomatoes.com)
- Through gene profile analyses of patients, the researchers documented that the association between patient psychological condition and survival time may stem from a dysregulation in inflammatory biology. (cnn.com)
- Survival analysis is a branch of statistics for analyzing the expected duration of time until one or more survival-ending events happen, such as death in biological organisms and failure in mechanical systems. (wikipedia.org)
- One element of survival analysis is the survival rate, the percentage of people in a study or treatment group still alive for a given period of time after diagnosis. (wikipedia.org)
Toughest1
- If that evidence comes to light, Rousseff will be facing her toughest fight for survival. (cnbc.com)
Analysis9
- Survival analysis regression aims at i. (amazonaws.com)
- Much like the majority of the media interest, this analysis focuses on the results for five-year survival from cancer. (www.nhs.uk)
- Of the 5,753,934 malignant adult cancers used in the survival analysis, 90% had been confirmed by microscopic analysis of tumour tissue. (www.nhs.uk)
- The paper on overall five-year survival described the results of the analysis of about 3m adult cancer cases that were diagnosed between 1995 and 1999 and followed until the end of 2003. (www.nhs.uk)
- The aim of this module is to familiarize the student with the basic concepts and models in survival analysis. (warwick.ac.uk)
- Analysis of survival data, Chapman and Hall, New York. (warwick.ac.uk)
- Counting processes and survival analysis, Wiley, New York. (warwick.ac.uk)
- Are you sure you want to remove Survival analysis from your list? (openlibrary.org)
- Survival, the bi-monthly publication from The International Institute for Strategic Studies, is a leading forum for analysis and debate of international and strategic affairs. (routledge.com)
Researchers1
- The researchers found that survival increased by 9 percent when people took high versus moderate doses of statin for a little over a year. (medicinenet.com)
Estimation1
- This work proposes MRI- and clinical information-based automated pipeline that implements various state-of-the-art image processing, machine learning, and deep learning techniques to obtain robust tumor segmentation and patient survival estimation. (springer.com)
Chemotherapy3
- Chemotherapy is associated with a greater survival advantage than radiotherapy and has added value when used with radiotherapy. (cochrane.org)
- This systematic review examines the effect of chemotherapy on survival after hysterectomy for endometrial cancer. (cochrane.org)
- After a median follow-up of 46.3 months, the median overall survival was 22.0 months with the combination versus 10.6 months with chemotherapy alone. (webmd.com)
Patients1
- Chato, L., Latifi, S.: Machine learning and deep learning techniques to predict overall survival of brain tumor patients using MRI images. (springer.com)
Rate1
- Survival rate can be used as yardstick for the assessment of standards of therapy. (wikipedia.org)
Cardiovascular disease1
- While studies have shown that social support, such as marriage, can have a significant impact on treatment of cardiovascular disease, the influence of marital status on stroke survival in adults remains poorly understood. (medicalnewstoday.com)
Stroke4
- People who were in a stable marriage, and had never been divorced or widowed, had the best prospects of survival after having a stroke , according to new research in Journal of the American Heart Association , the Open Access Journal of the American Heart Association/American Stroke Association. (medicalnewstoday.com)
- The risk factors associated with stroke -- high blood pressure , smoking and diabetes -- are well established, as are the factors related to recovering from stroke and improving survival, such as access to quality healthcare, reducing risk factors, and adhering to treatment plans. (medicalnewstoday.com)
- To determine whether one's marital history plays a role in survival after suffering a stroke, Dupre and Renato D. Lopes, M.D., Ph.D., professor of medicine at Duke University Medical Center, used data from a nationally representative sample of older U.S. adults. (medicalnewstoday.com)
- One possible reason for improved survival is that seniors living in closer neighborhoods have others looking out for them who can get help sooner if they start experiencing stroke symptoms. (prnewswire.com)
Episodes1
- Discovery Communications has learned that isolated elements of the 'Man vs. Wild' show in some episodes were not natural to the environment, and that for health and safety concerns the crew and host received some survival assistance while in the field," the network stated. (go.com)
Microscopic1
- Survival depends the risk of microscopic metastases after surgery. (cochrane.org)
Treatment2
- Many factors beyond treatment affect overall survival of a patient, including the biology of the cancer itself and the overall health or comorbidity of the patient diagnosed with cancer. (facs.org)
- The survival period is usually reckoned from date of diagnosis or start of treatment. (wikipedia.org)
Rescue2
- Since the primary goal of a survival kit for lost or injured persons is rescue, this part of the kit may be considered the most essential. (wikipedia.org)
- In this Safety Center you'll learn the importance of briefing your passengers before each flight to help prepare them for an emergency situation, essential ingredients of a good survival kit, simple but effective ways to help searchers find you, the first steps you should take after a crash, and survival strategies while awaiting rescue. (aopa.org)
Practice1
- For the average citizen to practice disaster preparedness, some towns will have survival stores to keep survival supplies in stock. (wikipedia.org)
Estimates1
- Data on some cancer sites was missing from the Danish data, and as this could affect overall survival estimates, Denmark was excluded from these overall analyses. (www.nhs.uk)
Prospects1
- Survival prospects are the same for early as for late re. (amazonaws.com)
Data5
- This important study analysed a vast amount of data on cancer survival in Europe. (www.nhs.uk)
- The data also included which cancer came first (if they were diagnosed with multiple primary cancers), whether the person was alive or dead, and when their survival status was last checked up. (www.nhs.uk)
- We look at the data using a Kaplan-Meier survival curve. (bmj.com)
- However, the data on diet and lifestyle associations with ovarian cancer survival are all observational," said McTiernan, who was not involved in the new study. (reuters.com)
- MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set. (springer.com)
Suggests2
- If its practical and you can afford it, a PLB (personal locator beacon) is a good way to ensure survival, short of that he suggests carrying a personal survival kit. (prweb.com)
- More positively, the term immortality suggests some superior quality of existence, whereas the term survival suggests mere temporal extension, a continuation of the status quo ante. (wikipedia.org)
Link2
- The amount of regular exercise women got before diagnosis did not seem to affect the link between diet quality and survival. (reuters.com)
- But a growing body of research from scientists studying ovarian, breast and other cancers continues to cement the link between psychological stress and disease, metastatic growth and survival. (cnn.com)
Stories4
- Survival stories like those of the family that recently found itself lost in Nevada show the importance of being prepared. (popularmechanics.com)
- With particular focus on the first-hand narratives of two desegregation pioneers-their stories, sufferings, and pedagogy of survival-this book gives voice to unsung heroes and the often overlooked view of the adolescent perspective to address the question of how one can endure and thrive in the midst of hardship and tragedy. (peterlang.com)
- For four harrowing survival stories and more advice from the experts, check out our "How I Survived" feature here . (popularmechanics.com)
- Survival Medicine Podcast The daily headlines are chock-full of stories about the COVID-19 pandemic. (blogtalkradio.com)
Understood1
- Darwin defines the biological concept of fitness as reproductive success, so in Darwinian terms the phrase is best understood as survival of the form that will leave the most copies of itself in successive generations. (wikipedia.org)