Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
INFLAMMATION of the LIVER.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Pathological processes of the LIVER.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A class of nongenotoxic CARCINOGENS that induce the production of hepatic PEROXISOMES and induce hepatic neoplasms after long-term administration.
Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.
A worm-like blind tube extension from the CECUM.
Cells that can carry out the process of PHAGOCYTOSIS.
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
The outer of the three germ layers of an embryo.
Somewhat flattened, globular echinoderms, having thin, brittle shells of calcareous plates. They are useful models for studying FERTILIZATION and EMBRYO DEVELOPMENT.
Societies whose membership is limited to physicians.
MOLECULAR BIOLOGY techniques used in the diagnosis of disease.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
... is a protein expressed in Kupffer cells. It is a critical receptor for the ... It recognizes iC3b (inactivated C3b) deposited on microbial surfaces. complement system immunoglobulin Helmy K, Katschke K, ... Cell. 124 (5): 915-27. doi:10.1016/j.cell.2005.12.039. PMID 16530040. v t e. ...
"Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers". ... sinusoidal endothelial cells, and Kupffer cells in the liver, as well as in the apical membranes of normal and malignant ... Measurements in cystic fibrosis cell line IB3 and its derivative cell line C38, which has a functional CFTR, showed increased ... "Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4 ...
B cells). They allow these cells to bind to antibodies that are attached to the surface of microbes or microbe infected cells, ... including Kupffer cells), and some dendritic cells. It is composed of two extracellular Ig-like domains, and is a member of ... The Fc receptor on NK cells recognize IgG that is bound to the surface of a pathogen-infected target cell and is called CD16 or ... The expression of CD16a and CD32a in a subset of activated CD4+ T cells is now confirmed. FcRs on the cell surface upon binding ...
Kupffer cells, and mast cells. These cells present receptors contained on the surface or within the cell, named pattern ... Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a ... it was unclear how NK cell recognize tumor cells and infected cells. It is now known that the MHC makeup on the surface of ... T cell subsets bearing invariant T cell receptors (TCRs), such as CD1d-restricted Natural Killer T cells, γδ T cells exhibit ...
... dendritic cells, histiocytes, Kupffer cells and mast cells. These cells possess surface receptors known as pattern recognition ... "Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells". Cell ... Phagocytes express cell-surface endocytic pattern recognition receptors (PRRs) that have affinity and efficacy against non- ... Such activation increases the affinity of bound integrin receptors for ICAM-1 and VCAM-1 on the endothelial cell surface, ...
... which causes osmotic lysis of the target cell. Kupffer cells and other macrophage cell types help clear complement-coated ... Host cells don't accumulate cell surface C3b (and the proteolytic fragment of C3b called iC3b) because this is prevented by the ... In contrast, when the internal thioester of C3 reacts with a hydroxyl or amino group of a molecule on the surface of a cell or ... Both of these disorders are currently thought to be due to complement overactivation either on the surface of host cells or in ...
The amoeboid shaped Kupffer cells are attached to sinusoidal endothelial cells. The surface of Kupffer cells contain microvilli ... Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized cells localized in liver within ... The average life of a Kupffer cell is around 3.8 days. The primary function of the Kupffer cell is to remove foreign debris and ... October 2019). "Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing ...
... giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance ... CD68 localizes primarily to lysosomes and endosomes but with a smaller fraction circulating to the cell surface; the scavenger ... Kupffer cells, osteoclasts, monocytes, and activated microglia in rat tissues. In this species, it is expressed in most ... Kupffer cells, microglia). Human CD68 is a transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a ...
1), and contain twice as many clathrin-coated pits per membrane unit, compared with two other major liver cells, Kupffer cells ... of the total liver cell volume, their surface in a normal adult human liver is about 210 m2, or nearly the size of a tennis ... endothelial and Kupffer cells". Cell and Tissue Research. 304 (2): 221-30. doi:10.1007/s004410100348. PMID 11396716. Sørensen, ... It is increasingly accepted that LSECs and Kupffer cells play complementary roles in the hepatic blood clearance process, ...
... macrophages and Kupffer cells, granulocytes, lymphocytes (T cells, B cells, and NK cells), megakaryocytes, and osteoclasts. ... PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion ... CD31 on endothelial cells binds to the CD38 receptor on natural killer cells for those cells to attach to the endothelium. ... a novel vascular cell-cell adhesion molecule". J. Cell Biol. 114 (5): 1059-68. doi:10.1083/jcb.114.5.1059. PMC 2289123. PMID ...
... being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly ... Hepatocytes are the main cells of the liver. They are large polyhedral cells, with six surfaces, three of which have a relevant ... Main liver cells are hepatocytes, Kupffer cells, and hepatic stellate cells; each one with a specific function. Cytology is the ... The main function of the Kupffer cells is the destruction of old blood cells that go through the liver. In the perisinusoidal ...
... which causes osmotic lysis of the target cell. Kupffer cells and other macrophage cell types help clear complement-coated ... Host cells don't accumulate cell surface C3b (and the proteolytic fragment of C3b called iC3b) because this is prevented by the ... In contrast, when the internal thioester of C3 reacts with a hydroxyl or amino group of a molecule on the surface of a cell or ... Once the alternative C3 convertase enzyme is formed on a pathogen or cell surface, it may bind covalently another C3b, to form ...
Hematopoietic cells (present in the liver in greater numbers before birth than afterward), Kupffer cells, and connective tissue ... Ectoderm, in the region of the proctodeum on the surface of part of the cloaca, proliferates and invaginates to create the anal ... Since the septum transversum is located initially opposite cervical segments of three to five, and since muscle cells for the ... whereas organs that lie against the posterior body wall and are covered by peritoneum on their anterior surface only are ...
The Kupffer cells in the liver are particularly rich in scavenger receptors, includes SR-A I, SR-A II, and MARCO. The scavenger ... Scavenger receptors are a large and diverse superfamily of cell surface receptors. Its properties were first recorded in 1970 ... CD36 can be found in many different cells, for example, insulin-responsive cells, hematopoietic cells like platelets, monocytes ... Scavenger receptors are mainly found on myeloid cells and other cells that bind to numerous ligands, primarily endogenous and ...
... from Kupffer Cells). or nitrous oxide (NO) and endothelin-1 (ET-1). ET-1 is the most potent vasoconstrictor under investigation ... binds G-protein linked cell surface receptors that activate adenylate cyclase to relax vascular smooth muscle. Prostacyclin - ... The muscular pulmonary arteries become fibrotic and hypertrophy while the smaller arteries lose smooth muscle cells and their ...
... sinusoidal endothelial cells, and phagocytic Kupffer cells. Hepatic stellate cells are nonparenchymal cells found in the ... The visceral surface or inferior surface is uneven and concave. It is covered in peritoneum apart from where it attaches the ... Histology, the study of microscopic anatomy, shows two major types of liver cell: parenchymal cells and nonparenchymal cells. ... Nonparenchymal cells constitute 40% of the total number of liver cells but only 6.5% of its volume. The liver sinusoids are ...
On NK cellsEdit. The Fc receptor on NK cells recognize IgG that is bound to the surface of a pathogen-infected target cell and ... including Kupffer cells), and some dendritic cells.[10] It is composed of two extracellular Ig-like domains, and is a member of ... Langerhans cells Phagocytosis. Degranulation (eosinophils) FcγRIIB1 (CD32) IgG Low (Kd , 10−7 M) B Cells. Mast cells No ... Mast cells. Follicular dendritic cells Induction of microbe killing FcεRI IgE High (Kd ~ 10−10 M) Mast cells. Eosinophils. ...
There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system. The ... I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation". European ... Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Benten WP, Stephan C, Wunderlich F (June 2002). "B cells express intracellular but not surface receptors for testosterone and ...
Adipose tissue macrophages Kupffer cell - Liver Alveolar macrophage (Dust cell) - Lung Langerhans cell - Skin Dermal macrophage ... Mucosal surfaces Respiratory tract antimicrobial defense system - Respiratory tract Neuroimmunology - Neuroimmune system in the ... Commonly termed CD4+ T cells Th1 cells Th2 cells Th3 cells Th17 cells TFH cells - Follicular helper T cells Cytotoxic T cells ... Dendritic Cells Plasmacytoid dendritic cells Lymphoid cells B cells Plasma B cells Memory B cells B-1 cells B-2 cells (the ...
... acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells ... It binds to TLR 2 and Dectin-1 (CLEC7A). Zymosan is a ligand found on the surface of fungi, like yeast. Zymosan is prepared ... from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In ...
Once a T cell has recognized its particular antigen on the surface of an aberrant cell, the T cell becomes an activated ... Investigations concerning Kupffer cells are hampered because in humans, Kupffer cells are only accessible for ... The processed antigen is then presented in MHCII on the surface of the B-cell. T cells that express the T cell receptor which ... Macrophages are a type of repairing cell that devour dead cells and pathogens, and trigger other immune cells to respond to ...
Healthy erythrocytes have a plasma life of about 120 days before they are degraded by the spleen, and the Kupffer cells in the ... surface area of all red blood cells of the human body would be roughly 2,000 times as great as the body's exterior surface. ... Sickle-cell anemia Disorders of cell proliferation Leukemia is a group of cancers of the blood-forming tissues and cells. Non- ... The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or ...
"The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma ... expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia". Journal of ... Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. ... Triggering receptor expressed on myeloid cells 1 (TREM-1) is a protein that in humans is encoded by the TREM1 gene. TREM-1 is a ...
2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 ( ... 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and ... analysis of its promoter indicates a region conveying cell type-specific expression". Mol. Cell. Biol. 10 (6): 2738-48. doi: ... Cell. Biol. 7 (9): 3221-30. doi:10.1128/MCB.7.9.3221. PMC 367958. PMID 3670312. Oikawa S, Nakazato H, Kosaki G (1987). "Primary ...
Hepatic stellate cell. *Kupffer cell. Biliary tract. Bile ducts. *Intrahepatic bile ducts *Bile canaliculus ... Cystic duct.Visceral surface of liver.. References[edit]. *^ editor-in-chief, Susan Standring ; section editors, Neil R. Borley ...
Peripheral macrophage as well as liver sinusoidal endothelial cells and Kupffer cells have been implicated in this process, ... a central cell surface receptor for S100/calgranulin polypeptides". Cell. 97 (7): 889-901. doi:10.1016/S0092-8674(00)80801-6. ... is found on many cells, including endothelial cells, smooth muscle, cells of the immune system[which?] from tissue such as lung ... AGEs affect nearly every type of cell and molecule in the body and are thought to be one factor in aging and some age-related ...
... sinusoidal endothelial cells (2.0%), and Kupffer cells (6.0%) after migrating and homing into the injured liver. Non-Muse bone ... The surface of the bottom of each culture dish or well must be coated with poly-HEMA to avoid adhesion of the cells. Long-term ... When mesenchymal cells (sometimes called mesenchymal stem cells) are separated into Muse and non-Muse cells by SSEA-3 cell ... Therefore, Muse cells are double positive for pluripotent and mesenchymal stem cell markers. Cell isolation by SSEA-3 cell ...
"Wnt family proteins are secreted and associated with the cell surface". Molecular Biology of the Cell. 4 (12): 1267-75. doi: ... Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells". PLOS ONE. 10 (11): e0142794. Bibcode:2015PLoSO..1042794C ... particularly hematopoietic cells, intestinal cells, hair follicle and germ cells. • Differentiated tumor cells in a state of ... Clevers H, Nusse R (June 2012). "Wnt/β-catenin signaling and disease". Cell. 149 (6): 1192-205. doi:10.1016/j.cell.2012.05.012 ...
The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surfaces via specific ... probably indirectly via Kupffer cells), which leads to eosinophilic degradation of these cells and to the release of cytokines ... After entering the host cell, the viral genome is replicated in the rough endoplasmic reticulum (ER) and in the so-called ... After transmission from a mosquito, the viruses replicate in the lymph nodes and infect dendritic cells in particular. From ...
They are unusual cells in that they have villi on their surface which in turn have innumerable microvilli on their surface. All ... These include the various cells of the gastric glands, taste cells, pancreatic duct cells, enterocytes and microfold cells. ... The olfactory receptors are located on cell surfaces in the nose which bind to chemicals enabling the detection of smells. It ... which is either secreted by surface cells or more usually by underlying glands. The mucous membrane in the mouth continues as ...
To date, it is recognized as the main cell surface receptor for HA. CD44 mediates cell interaction with HA and the binding of ... Kupffer cells and sinusoidal endothelial cells from rat liver". Hepatology. 11 (2): 199-204. doi:10.1002/hep.1840110207. PMID ... and control of the cell locomotory mechanisms are mediated via the specific cell interaction between HA and cell surface HA ... "CD44 is the principal cell surface receptor for hyaluronate". Cell. 61 (7): 1303-13. doi:10.1016/0092-8674(90)90694-a. PMID ...
Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... SBF is normally used for the surface modification of metallic implants, and more recently in gene delivery application. ... Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension ... this makes plasma the extracellular matrix of blood cells. It makes up about 55% of the body's total blood volume.[1] It is the ...
Cell surface receptors allow neutrophils to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon ... Any ANC , 1500 cells / mm3 is considered neutropenia, but ,500 cells / mm3 is considered severe.[46] There is also new research ... PECAM-1 and phosphatidylserine on the cell surface are involved in this process. ... HSC=Hematopoietic stem cell, Progenitor=Progenitor cell, L-blast=lymphoblast, Lymphocyte, Mo-blast=Monoblast, Monocyte, ...
There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system.[27] ... I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation". European ... Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate ... Benten WP, Stephan C, Wunderlich F (June 2002). "B cells express intracellular but not surface receptors for testosterone and ...
... s have protein receptors on their cell surface that bind IgE, an immunoglobulin involved in macroparasite defense and ... Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... "Distinguishing mast cell and granulocyte differentiation at the single-cell level". Cell Stem Cell. 6 (4): 361-8. doi:10.1016/j ... This article is about a type of blood cell. For the endocrine cell of the anterior pituitary, see basophil cell. ...
Activated platelets have cell membrane projections covering their surface. Platelets are found only in mammals, whereas in ... Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... Berridge, Michael J. (1 October 2014). "Module 11: Cell Stress, Inflammatory Responses and Cell Death". Cell Signalling Biology ... "Programmed anuclear cell death delimits platelet life span". Cell. 128 (6): 1173-86. doi:10.1016/j.cell.2007.01.037. PMID ...
This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion ... Kupffer cells. *Alveolar macrophage. *Microglia. *Osteoclasts. *Epithelioid cells. *giant cells *Langhans giant cells, Foreign- ... Väänänen H, Zhao H, Mulari M, Halleen J (2000). "The cell biology of osteoclast function". J Cell Sci. 113 (3): 377-81. PMID ... Vaananen, H.K.; H. Zhao; M. Mulari; J.M. Halleen (2000). "The cell biology of osteoclast function". Journal of Cell Science. ...
I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation". European ... It is the surface of the body opposite from the chest. The vertebral column runs the length of the back and creates a central ... Beta cell - Beta cellscells) are a type of cell found in pancreatic islets that synthesize and secrete insulin. Beta cells ... White blood cell - White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are ...
... protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces; ... Hinglais N, Kazatchkine MD, Mandet C, Appay MD, Bariety J (November 1989). "Human liver Kupffer cells express CR1, CR3, and CR4 ... CR1, a surface protein produced primarily by follicular dendritic cells, appears to be critical for generation of appropriately ... The gene is expressed principally on erythrocytes, monocytes, neutrophils and B cells but is also present on some T lymphocytes ...
Cavernous hemangioma M9122/0 Venous hemangioma M9123/0 Racemose hemangioma Arteriovenous hemangioma M9124/3 Kupffer cell ... Papillary serous adenocarcinoma Micropapillary serous carcinoma M8461/0 Serous surface papilloma (C56.9) M8461/3 Serous surface ... cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell ... M8550/0 Acinar cell adenoma Acinar adenoma Acinic cell adenoma M8550/1 Acinar cell tumor Acinic cell tumor M8550/3 Acinar cell ...
The mixed PEG ligands were grafted to the nanoparticle surface at a density of 5 PEG·nm−2 to passivate the surface against the ... Depletion and repopulation of Kupffer cells in BALB/c mice. The number of Kupffer cells from fixed areas of tissue were ... that phagocytic Kupffer cells near the portal triads were depleted to a greater extent in comparison with the Kupffer cells ... Kupffer cells and nanoparticle tumor delivery. Anthony J. Tavares, Wilson Poon, Yi-Nan Zhang, Qin Dai, Rickvinder Besla, Ding ...
The amoeboid shaped Kupffer cells are attached to sinusoidal endothelial cells. The surface of Kupffer cells contain microvilli ... Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized cells localized in liver within ... The average life of a Kupffer cell is around 3.8 days. The primary function of the Kupffer cell is to remove foreign debris and ... October 2019). "Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing ...
Kupffer cells explanation free. What is Kupffer cells? Meaning of Kupffer cells medical term. What does Kupffer cells mean? ... Looking for online definition of Kupffer cells in the Medical Dictionary? ... Kupffer cell sarcoma. Kupffer cells - phagocytic cells of the mononuclear phagocyte series found on the luminal surface of the ... Related to Kupffer cells: Space of Disse. Kupf·fer cells. (kūpfĕr), phagocytic cells of the mononuclear phagocyte series found ...
Kupffer cell CD163 cell surface marker mRNA expression in Hep:KC cultures. Hepatocytes were cultured alone (in micropatterned ... hepatocyte-Kupffer cell. IFN. interferon. IL. interleukin. IL-1RA. interleukin-1 receptor antagonist cytokine. IL-1R1. IL-1 ... Kupffer cells. LPS. lipopolysaccharide. mAb. monoclonal antibody. MPCC. micropatterned coculture. P450. cytochrome P450. RT-PCR ... Hepatocyte-Kupffer Cell Coculture for Studying Cytokine Effects. Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, ...
Phenotypic, developmental, and functional aspects of these cells in... ... Kupffer cells (KC), the resident macrophages of the liver, represent the largest population of mononuclear phagocytes in the ... Ofek I, Sharon N (1988) Lectinophagocytosis: a molecular mechanism of recognition between cell surface sugars and lectins in ... Wan J, Benkdane M, Teixeira-Clerc F, Bonnafous S, Louvet A, Lafdil F et al (2014) M2 Kupffer cells promote M1 Kupffer cell ...
Cells were also present on the top surface of the scaffolds. Kupffer cells cocultured in this format have previously been ... 2001) Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury. Am J Physiol ... and cocultures with liver nonparenchymal cell types such as Kupffer cells (KCs), liver sinusoidal endothelial cells, and ... Kupffer cell. LC-MS/MS. liquid chromatography with tandem mass spectrometry. LV. lovastatin. PBS. phosphate-buffered saline. PK ...
Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells. It is a critical receptor for the ... It recognizes iC3b (inactivated C3b) deposited on microbial surfaces. complement system immunoglobulin Helmy K, Katschke K, ... Cell. 124 (5): 915-27. doi:10.1016/j.cell.2005.12.039. PMID 16530040. v t e. ...
Analysis of cell surface by xenogenic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell 12: 663. ... Kupffer cells) and kidney. In the lung, staining was confined to alveolar Mφ (Fig. 6⇓b), and was not detected on interstitial M ... Cloning cell surface molecules by transient expression in mammalian cells. D. A. Hartley, ed. Cellular Interactions in ... Cells, culture conditions, and NO synthesis. The rat pleural Mφ cell line R2 (13, 16) and the NR8383 rat alveolar Mφ cell line ...
a RAW264.7 cells were stained with F4/80 antibody, a surface marker of Kupffer cells, and analysed by flow cytometry. ... we used an in vitro cell-cell co-culture system with the murine-derived RAW264.7 cell line to represent Kupffer cells, which ... whereas MSC infusion restored Kupffer cells by inhibiting apoptosis. The protected Kupffer cells suppressed Th1/Th17 cells and ... The administration of 20 mg/Kg doses of GdCl3 causes Kupffer cell apoptosis and selectively blocks Kupffer cell effector ...
... are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of presumable epithelial origin and ... Kupffer cells, if present, are reduced in number and are nonfunctional. Hepatic adenomas are tan in color, smooth, well ... They have large blood vessels on the surface, and the lesions may outgrow their arterial blood supply, causing necrosis within ... Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol. 2009 Mar. 16(3):640-8. [ ...
Both Kupffer cells and HSCs express TLR4 on their cell surface. In wild-type mice whose Kupffer cells (but not HSCs) were ... Thus, LPS in the liver, by decreasing the abundance of Bambi on the surface of HSCs, increases their responsiveness to Kupffer ... In the liver, fibrosis is due to Kupffer cells (liver macrophages), which produce transforming growth factor-β (TGF-β), a ... but not Kupffer cells) was important for fibrosis. LPS treatment of HSCs isolated from Coll-GFP reporter mice [in which the ...
Cytokines are proteins or glycoproteins produced by cells acting on their specific receptors on the other cells surfaces. They ... Hepatocyte damage persuades an inflammatory response through activation of tissue macrophage Kupffer cells [3]. These activated ... TNF-α is produced mainly by macrophages and also by a broad variety of other cell types including lymphoid cells, mast cells, ... and cell death [9]. In the liver, TNF-α is involved in pathophysiology of viral hepatitis, alcoholic liver disease, ...
Here we show that expression of the proinflammatory myeloid cell surface receptor TREM-1 expressed by Kupffer cells is a ... The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma. ... The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma ... The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma ...
NP size is more important than number and size of peptides bound to NP surface in governing successful NP-cell surface receptor ... Kupffer cells of the liver (Tsoi et al. 2016) and splenic macrophages (Cataldi et al. 2017) have been recognized to contribute ... Tumor dynamics are primarily governed by cell division, cell death, cell migration, and cell-cell and cell-extracellular matrix ... the latter involves surface functionalization of NPs with ligands specific to receptors on the tumor cell surface. A prolonged ...
debris can be demonstrated in the fixed macrophages and Kupffer cells lining the hepatic sinusoids; - role of ceramic bearing ... ceramic bearing surfaces have offered hope in some series of decreasing osteolysis by minimizing wear debri; - it is noted that ... osteolysis is mediated primary by macrophages (fibroblasts and endothelial cells also play a role); - these cells are activated ... Cellular biology of bone-resorbing cells. Aseptic loosening in total hip arthroplasty secondary to osteolysis induced by wear ...
... the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential ... in magnetic cell separation assays, and are suitable to be engineered in terms of size, targeted delivery and substance release ... morphology and surface charge are the three important parameters for their behavior in the bloodstream. Kupffer cells in the ... The results were similar in all the tumor cell lines tested: human breast cancer cell line (MCF-7), human fibrosarcoma cells, ...
... cell membrane blebbing, and breakdown of cell membrane asymmetry with phosphatidylserine exposure at the cell surface. Triggers ... Erythropoietin Enhances Kupffer Cell Number and Activity in the Challenged Liver Scientific Reports. Sep, 2017 , Pubmed ID: ... Jul, 2012 , Pubmed ID: 22490927 Erythropoietin acts by binding to its cell surface receptor on erythroid progenitor cells to ... Upregulation of HIF-1alpha mRNA was also observed in D6 cells but not in P34 cells. Thus, the high-metastatic cells produced a ...
... a molecule that results in a higher affinity binding to a target cell (e.g., B-cell or natural killer (NK) cell) surface and/or ... About 50% of all macrophages are found in the liver as Kupffer cells. They are also present in the brain as microglia, in the ... Immune Response: A response of a cell of the immune system, such as a B cell or T cell to a stimulus. In one embodiment, the ... Cell Mol. Biol. 20:561-572, 1999; Yuen et al., Am. J. Respir. Cell Mol. Biol. 15:268-274, 1996), silica instillation also ...
Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers ... Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells GREENWALD I. ... The regulation of primary mesenchyme cell migration in the sea urchin embryo : transplantations of cells and latex beads ... Phorbol esters alter cell fate during development of sea urchin embryos LIVINGSTON B. T. ...
Kupffer cells are liver-resident macrophages that show high levels of the cell-surface marker F4/80. Activated Kupffer cells ... Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how? World J Hepatol 2015;7 ... Cell Signaling Technology), and secondary antibodies (7074; Cell Signaling Technology). ... Note that infiltration of T cells was not evident histologically or by CD4/CD8 gene expression. Serum levels of IL-6 and TNF-α ...
... endothelial cell swelling, cell surface recesses and protrusions, and vacuolization related to intracellular edema and ... In the sinusoids, there were partial dilatations and Kupffer cells protruding into the lumen observed to be flat, round, and ... The sinusoidal wall-settled Kupffer cells were observed to be more flat and stained deep basophilically (Figure 1(c)). ... In the tissues stained with H&E, it was observed that cell damage in the I/R group was significantly high, while it was low in ...
RAW cells showed significant ST activity on their surfaces. ST activity has also been found on the surface of dendritic cells ... Examples include clearance of erythrocytes or platelets with reduced sialic acid residues by Kupffer cells (30, 31) or ... monocyte-derived dendritic cells, lymphocytes, and T cells (48, 49, 51⇓-53, 80). Presence of ST on the cell surface or in serum ... the population of cells that express PrPC could be different from the population of cells that express cell surface STs. In ...
Hepatocytes and Kupffer Cells, Model Normal and Inflamed Liver, Evaluate cytokine-mediated toxicity. Our hepatic co-cultures ... Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function. Zinchenko YS, et. Al. 2006 ... Non-parenchymal cells better represent normal liver physiology Our hepatic co-cultures using kupffer cells are powerful new in ... This suggests cellular self assembly between Kupffer cells and hepatocytes that synergistically allows those cells to function ...
... with FcγR expressed on the surface of Kupffer cells to trigger erythrophagocytosis. ... Ab-dependent cell-mediated cytotoxicity by NK cells, and degranulation of mast cells (2). Each FcγR displays different binding ... 2⇓)). Histological analysis confirmed the complete absence of iron deposits in Kupffer cells in FcRγ−/− B6 mice (data not shown ... and the extent of in vivo RBC destruction by Kupffer cell-mediated phagocytosis was determined by Perls iron staining. ...
An understanding on the specificities of a protective B cell response, the molecular locations of these epitopes on E1, E2 and ... Both, NK cells and the highly abundant Kupffer cells are able to mediate ADCC. Recent publications suggest that ADCC mediated ... A key issue is the lack of clear evidence of infected cells expressing surface HCV-encoded antigens. ... While there is some debate whether B cell versus T cell responses are necessary for an effective HCV vaccine (9), a brief ...
2015) recently identified the host molecule, CD68, as an important surface receptor on rat Kupffer cells for sporozoite entry. ... A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins. Mol. Cell. Proteomics. 12:3976- ... Traversal through Kupffer cells is thought to activate the sporozoite for invasion (Mota et al., 2002). Using a complex phage ... Cell surface glycosaminoglycans are not obligatory for Plasmodium berghei sporozoite invasion in vitro. Mol. Biochem. Parasitol ...
Kupffer cells, KCs) in the liver can undergo both pro- or anti-inflammatory activation pathway and exert either beneficiary or ... that undergo local activation in response to various stimuli and express distinct patterns of surface markers, chemokines and ... Sun Z, Wada T, Maemura K, Uchikura K, Hoshino S, Diehl AM, Klein AS: Hepatic allograft-derived Kupffer cells regulate T cell ... Table 1 Effect of HF diet and Kupffer cells reduction on lipid and glucose metabolism parameters in serum. Full size table. ...
... proper Kupffer cells are liver macrophages).. Gastric Surface Mucous Cells. The protective epithelial cells which line the ... Kupffer Cells (Liver Macrophages). Kupffer cells are macrophages found in the sinusoids of the liver. These cells have standard ... Stem Cells. Stem cells are undifferentiated cells which remain capable of cell division to replace cells which die. In the ... cells. Since the mucosal surface of the stomach consists of these cells and no others, individual surface mucous cells cannot ...
The AMG technique is based on the catalytic qualities of gold nanoparticles causing silver ions adhering to their surfaces to ... Following IV injection, the Kupffer cells were heavily loaded after one hour, while only a fraction of the cells were lightly ... Gold NanoparticlesKupffer CellColloidal GoldPregnant AnimalColloidal Gold Nanoparticles. Background. Nanotechnology is a ... All the Kupffer cells were loaded. In the animals injected IV with 2 nm nanoparticles, the load of AMG silver enhanced ...
62 Cell surface expression is low but detectable after stimulation.63 Macrosialin is highly expressed in rat Kupffer cells but ... SR-A is expressed by tissue macrophages, aortic endothelial cells, liver sinusoidal endothelial cells, and Kupffer cells.9 10 ... Rat liver Kupffer and endothelial cells express different binding proteins for modified low density lipoproteins: Kupffer cells ... In these activated Kupffer cells, SR-A is responsible for ≈35% of cell adhesion (A.G.v.V. et al, unpublished data, 2000). ...
  • The SR-AI/II scavenger receptor is found inside Kupffer cells. (wikipedia.org)
  • Byun JS, Suh YG, Yi HS, Lee YS, Jeong WI (2013) Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. (springer.com)
  • Complement receptor of the immunoglobulin family is a protein expressed in Kupffer cells. (wikipedia.org)
  • Three classes of activating FcγR (FcγRI, FcγRIII, and FcγRIV) and one inhibitory receptor (FcγRIIB) are expressed on murine immune effector cells ( 1 ). (jimmunol.org)
  • They were first described for macrophages as alternative receptors to the LDL receptor in the uptake of (excessive) cholesterol and lipid, leading to the development of foam cells. (ahajournals.org)
  • Another study, which used P388D1 murine macrophages, showed differences in the expression levels of SR-AI and SR-AII, 5 with the type I receptor expression by P338D1 cells substantially less than that of the type II receptor. (ahajournals.org)
  • G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways. (frontiersin.org)
  • G protein-coupled bile acid receptor 1 (TGR5, also known as GPBAR1) is a cell surface receptor that specifically binds to bile acids ( 6 , 7 ). (frontiersin.org)
  • Here we show that expression of the proinflammatory myeloid cell surface receptor TREM-1 expressed by Kupffer cells is a crucial factor in the development and progression of liver cancer. (aacrjournals.org)
  • Each fiber monomer is comprised of an amino-terminus that is noncovalently anchored to the penton base, a carboxy-terminus globular domain that binds to the cell surface receptor, and a rod-like shaft that varies in length according to the Ad serotype. (pubmedcentralcanada.ca)
  • Heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor. (slicksurface.com)
  • A newly-identified human endothelial cell homolog of the mouse Kupffer-cell receptor (Clec4F, member of C-type lectins) has been cloned from DNA sequence of human langerin. (acris-antibodies.com)
  • Iafrate, Bronson, Skowronski: Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. (antikoerper-online.de)
  • Receptor-mediated endocytosis of VEGF-A in rat liver sinusoidal endothelial cells. (uio.no)
  • Enhanced activity of lysosomal proteases in activated rat hepatic stellate cells is associated with a concomitant increase in the number of the mannose-6-phosphate/insulin-like growth factor II receptor. (uio.no)
  • Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by Fc gamma RIIb2. (uio.no)
  • Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180. (uio.no)
  • The cloned cells expressed many enzymes and markers that are typical of native Kupffer cells (non-specific esterase, peroxidase, MOMA-2, BM8, scavenger receptor A, CD14 and Toll-Like-Receptor 4 (TLR4), the antigen-presenting molecules CD40, CD80 and CD1d, and endocytosed Dextran-FITC. (forschung3r.ch)
  • Feinberg H, Taylor ME, Weis WI (2007) Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis x by a novel mechanism. (functionalglycomics.org)
  • Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissue cells cannot explain the tolerance mechanism at the effector phase. (rupress.org)
  • Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. (thermofisher.com)
  • F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). (thermofisher.com)
  • In previous experiments, cell-surface heparan sulfate proteoglycans extracted from human lung fibroblasts could not be shown to promote high affinity binding of bFGF when added to heparan sulfate-deficient cells that express FGF receptor-1 (FGFR1) (Aviezer, D., D. Hecht, M. Safran, M. Eisinger, G. David, and A. Yayon. (rupress.org)
  • Cells cotransfected with receptor and proteoglycan showed a two- to three- fold increase in neutral salt-resistant specific 125I-bFGF binding in comparison to cells transfected with only receptor or cells cotransfected with receptor and anti-syndecan-4. (rupress.org)
  • Exogenous heparin enhanced the specific binding and affinity cross-linking of 125I-bFGF to FGFR1 in receptor transfectants that were not cotransfected with proteoglycan, but had no effect on this binding and decreased the yield of bFGFR cross-links in cells that were cotransfected with proteoglycan. (rupress.org)
  • Receptor-transfectant cells showed a decrease in glycophorin A expression when exposed to bFGF. (rupress.org)
  • Finally, complementary cell-free binding assays indicated that the affinity of 125I-bFGF for an immobilized FGFR1 ectodomain was increased threefold when the syndecan-4 ectodomain was coimmobilized with receptor. (rupress.org)
  • Drug induced receptor cell surface r adrenergic antagonists are competitive antagonists adrenergic beta 1 receptor antagonists. (lookformedical.com)
  • Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized cells localized in liver within the lumen of the liver sinusoids and are adhesive to their endothelial cells which make up the blood vessel walls. (wikipedia.org)
  • In the liver, fibrosis is due to Kupffer cells (liver macrophages), which produce transforming growth factor-β (TGF-β), a primary inducer of liver fibrosis, and hepatic stellate cells (HSCs), which differentiate into extracellular matrix-producing myofibroblasts. (sciencemag.org)
  • TLR4 signaling sensitizes hepatic stellate cells to TGF-β, thus enhancing fibrogenesis. (sciencemag.org)
  • For Liver I have the following cells: hepatocytes, Kupffer cells, stellate cells & liver sinusoidal endothelial cells. (thestudentroom.co.uk)
  • Importantly, Ad5-3Δ-A20T infected pancreatic stellate cells at low levels, which may further facilitate viral spread and cancer cell elimination either as a single agent or in combination with the chemotherapy drug, gemcitabine. (aacrjournals.org)
  • Non-parenchymal cells consisted of endothelial cells, Kupffer cells, stellate cells and pit cells localized in and around the angular sinusoids. (up.ac.za)
  • Stellate cells occupied a subendothelial position in the space of Disse and contained prominent lipid droplets that indented the nuclei. (up.ac.za)
  • Myofibroblastic cells were found in the same region as stellate cells. (up.ac.za)
  • Up-regulation of uPARAP/Endo180 during culture activation of rat hepatic stellate cells and its presence in hepatic stellate cell lines from different species. (uio.no)
  • Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells. (uio.no)
  • There are about 40 different cell types that make up a human liver, including Kupffer cells for removing debris from the blood, stellate cells for regenerating tissue that has died or been injured, and sinusoidal endothelial cells, which make up the interior surface of blood vessels and lymphatic vessels. (cio-asia.com)
  • In addition, we show for the first time that rat SIRP is selectively expressed by myeloid cells (macrophages, monocytes, granulocytes, dendritic cells) and neurons. (jimmunol.org)
  • Here we show by expression cloning and immunocytochemistry that the mAbs ED9, ED17, and MRC-OX41 recognize a rat SIRP and that rat SIRP is selectively expressed by myeloid cells (monocytes, Mφ, granulocytes, dendritic cells (DC)) and neurons. (jimmunol.org)
  • Opsonization is the process by which a foreign organism or particle becomes covered with nonspecific proteins, thereby making it more visible to phagocytic cells (e.g., monocytes, macrophages, neutrophils and dendritic cells). (pubmedcentralcanada.ca)
  • Follicular dendritic cells (DENDRITIC CELLS, FOLLICULAR) are also considered to be antigen-presenting cells by some authors. (slicksurface.com)
  • CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells. (uniklinik-ulm.de)
  • Coloured scanning electron micrograph (SEM) of a protective cell of the human immune system known as a dendritic cell. (sciencephoto.com)
  • Dendritic cells process foreign antigens then act like an alarm signal, alerting other immune cells of the body to the infection. (sciencephoto.com)
  • Dendritic cells found in the upper layer of the skin (the epidermis) are known as histiocytes or Langerhans cells. (sciencephoto.com)
  • In the central nervous system dendritic cells are known as microglia, and in the liver as Kupffer cells. (sciencephoto.com)
  • Dendritic cells show low to intermediate expression. (acris-antibodies.com)
  • Macrosialin is a heavily glycosylated transmembrane protein of 87-115 kDa, which is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. (acris-antibodies.com)
  • Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. (acris-antibodies.com)
  • The process of acute inflammation is initiated by cells already present in all tissues, mainly resident macrophages, dendritic cells, histiocytes, Kupffer cells and mastocytes. (academic.ru)
  • It is a member of animal β-galactoside-binding protein family that is expressed in cell nucleus, cytoplasm, plasma membrane, or extracellular matrix by variety of tumor cells, monocytes/macrophages, epithelial cells, Kupffer cells, and dendritic cells. (biolegend.com)
  • Flow cytometric analysis demonstrates that rmC5-3 antibody stains J774A.1 (mouse macrophage line), WEHI-265.1 (mouse monocytic line), peritoneal resident macrophages, Kupffer cells, and cultured bone marrow-derived macrophages and dendritic cells, but not unstimulated splenic macrophages, dendritic cells, neutrophils, or blood monocytes. (fishersci.com)
  • Levels of CD14 expression on Kupffer cells and bone marrow-derived macrophages and dendritic cells of LPS-sensitive mice are increased by in vivo and in vitro LPS treatments, an effect which may be mediated by TNF. (fishersci.com)
  • However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. (thermofisher.com)
  • F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. (thermofisher.com)
  • dendritic cells , histiocytes, Kupffer cells and mast cells . (lookformedical.com)
  • However, the role of stimulating macrophage colony seems to be the most important in the developing of mature Kupffer cells. (wikipedia.org)
  • Fixed MACROPHAGE cells that line the fine blood sinuses (capillaries) of the liver and act as scavengers to remove senescent red blood cells, bacteria and other foreign material. (thefreedictionary.com)
  • Hepatocyte damage persuades an inflammatory response through activation of tissue macrophage Kupffer cells [ 3 ]. (hindawi.com)
  • Enhanced sialylation of PrP Sc is recapitulated in vitro by incubating brain-derived PrP Sc with primary splenocytes or cultured macrophage RAW 264.7 cells. (pnas.org)
  • This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. (cdc.gov)
  • An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. (cdc.gov)
  • This type of immunity is a long-term immunity which is acquired when a macrophage digests a microbe and presents the microbe's antigen on its surface to alert other white blood cells to the presence of the invading particle. (news-medical.net)
  • Both liver and adipose tissue possess a specific macrophage subpopulation -"resident macrophages"- that undergo local activation in response to various stimuli and express distinct patterns of surface markers, chemokines and cytokines [ 3 ]. (biomedcentral.com)
  • It is a macrophage cell that is found in the body's tissues. (sciencephoto.com)
  • 2002) showed that BM8 antibody is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas and has been shown to be a unique histological marker of the progression from peri-insulitis to ß-cell destruction and diabetes in a mouse diabetes model. (acris-antibodies.com)
  • ER-MP20 antibody is useful for the detection of macrophage precursor cells in the mid-stage development stage (Ly-6C, late CFU-M, monoblasts and monocytes) (s. (acris-antibodies.com)
  • It is the optimal tool for detection of cells of the macrophage/monocyte lineage by flow cytometry and is available with different labels. (acris-antibodies.com)
  • Here, we have explored the surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition. (aspetjournals.org)
  • More recent studies using BCG infection have provided some additional information on macrophage dynamics and T cell motility within hepatic granulomas during this infection [19] but fail to directly address KC function. (prolekarniky.cz)
  • Ishibashi, "The role of neutral cholesterol ester hydrolysis in macrophage foam cells ," Journal of Atherosclerosis and Thrombosis, vol. (thefreedictionary.com)
  • At day 12, the mice were intraperitoneally injected with [sup.3]H-cholesterol-labeled macrophage-derived foam cells , and the rate of macrophage RCT was determined [19]. (thefreedictionary.com)
  • The amoeboid shaped Kupffer cells are attached to sinusoidal endothelial cells. (wikipedia.org)
  • On the other hand, the adherence of T cells to hepatic sinusoidal endothelium was significantly increased after ConA activation, especially in the periportal area, and this increase was attenuated by an anti-intercellular adhesion molecule (ICAM)-1 antibody. (physiology.org)
  • Endothelial cells were flat cells with long fenestrated cytoplasmic extensions that lined the sinusoidal wall and contained numerous endocytotic vesicles and many lysosomes. (up.ac.za)
  • Pleomorphic Kupffer cells were located in the sinusoidal lumen, in the space of Disse and within groups of hepatocytes. (up.ac.za)
  • Pit cells with indented eccentric nuclei were found in the sinusoidal lumen and in close contact with endothelial and Kupffer cells. (up.ac.za)
  • Liver nonparenchymal cells including sinusoidal endothelial cells and Kupffer cells constitutively expressed PD-L1 and inhibited proliferation and cell division of activated T cells expressing PD-1. (rupress.org)
  • Rows of hepatocytes radiate from the central hepatic vein and are separated by sinusoidal spaces along the walls of which are interspersed hepatic macrophages, the Kupffer Cells. (writework.com)
  • It will reduce and replace studies with primary Kupffer cells obtained from mice. (forschung3r.ch)
  • If the Kupffer cells derived from the transgenic mice prove functionally normal, they will replace studies with primary Kupffer cells. (forschung3r.ch)
  • Between the cords of hepatocytes the sinusoids were lined with endothe-lial cells having flattened dark nuclei and Kupffer cells with nuclei projecting into the sinusoids which opened into the central vein. (thefreedictionary.com)
  • Morphometric Observations: The details of Volume density of hepatocytes (Vvh) and Numerical density of Kupffer cells on the area (Nak) are summarized in Table 4. (thefreedictionary.com)
  • Studies indicate that co-culture of hepatocytes with kupffer cells would better represent both normal liver physiology as well as disease states. (thermofisher.com)
  • These models enable researchers to study the interactions between hepatocytes and Kupffer cells during liver inflammation. (thermofisher.com)
  • This suggests cellular self assembly between Kupffer cells and hepatocytes that synergistically allows those cells to function together during resolution of inflammation. (thermofisher.com)
  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. (thermofisher.com)
  • Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. (thermofisher.com)
  • Part b I'm guessing it's because different cells have different functions and so need to be different sizes, despite being on the same organ ie in the kidney you have the hepatocytes, which make up most of the mass so obviously need to have a large surface area and a large size, and kupffer cells which are elongated as they're macrophages, so need to adapt their shape to engulf microbes. (thestudentroom.co.uk)
  • The parenchymal component occupied the largest part of the liver and was formed by anastomosing and branching cell cords consisting of two-cell-thick plates in the longitudinal sectional plane and at least five hepatocytes in the cross-sectional plane. (up.ac.za)
  • The space of Disse existed between endothelial cells and the base of the hepatocytes which was lined by microvilli. (up.ac.za)
  • Occasional intercalated cells resembling lymphocytes were seen in the space of Disse and forming part of the groups of hepatocytes. (up.ac.za)
  • ABCAI, ABCGI and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. (uio.no)
  • Apical surface of hepatocytes faces bile canaliculi. (brainscape.com)
  • Insulin also induces iron transport and accumulation in hepatocytes by a similar mechanism ( 2 ) and is responsible for increased ferritin synthesis in cultured rat glioma cells ( 3 ). (diabetesjournals.org)
  • Monocytes that are in the peripheral circulation and come from precursor cells in the bone marrow, are thought to be immature precursors for tissue macrophages, in adult animals. (wikipedia.org)
  • However, inflammatory conditions allow rapid differentiation of monocytes into mature cells that are indistinguishable from genuine KC. (springer.com)
  • any of the large, mononuclear, highly phagocytic cells derived from monocytes , occurring in the walls of blood vessels (adventitial cells) and in loose connective tissue (histiocytes, phagocytic reticular cells). (thefreedictionary.com)
  • Macrophages are formed through differentiation of monocytes, one of the major groups of white blood cells of the immune system. (news-medical.net)
  • The agranulocytes are lymphocytes (consisting of B cells and T cells) and monocytes . (hartford.edu)
  • Monocytes get attracted to and accumulate in the subendothelial space where they take up lipids to become foam cells [42]. (thefreedictionary.com)
  • The Ig superfamily constitutes a major group of cell surface receptors involved in recognition and/or communication ( 1 ). (jimmunol.org)
  • Cytokines are proteins or glycoproteins produced by cells acting on their specific receptors on the other cells' surfaces. (hindawi.com)
  • 2014 ). Whereas the former phenomenon depends on the leakiness of tumor vessels (defined as enhanced permeability and retention or EPR effect) (Jain and Stylianopoulos 2010 ), the latter involves surface functionalization of NPs with ligands specific to receptors on the tumor cell surface. (springer.com)
  • Phagocytic cell surfaces contain specialized receptors that interact with the modified conformation of these various opsonins, thus alerting them to the presence of a nanoparticle. (pubmedcentralcanada.ca)
  • Ad entry into host cells involves specific interactions between cell surface receptors and viral capsid proteins. (pubmedcentralcanada.ca)
  • Several cell surface molecules have been identified as receptors for Ad attachment and entry. (pubmedcentralcanada.ca)
  • In this review, we discuss the various cell surface molecules that are implicated as receptors for virus attachment and internalization. (pubmedcentralcanada.ca)
  • In particular, BAs may attenuate the inflammatory response transcriptionally but also could compromise lipopolysaccharide (LPS) clearance by attenuating the expression of scavenger receptors as well as autophagy, a cell survival response. (biomedcentral.com)
  • Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells. (uio.no)
  • They differentiate at 39 o C. These cells are now being characterised: cytokine and NO liberation is stimulated, surface receptors are assessed at the mRNA and protein level, and phagocytosis and uptake of bacterial components are being measured. (forschung3r.ch)
  • The role of glycan-binding receptors as tags for uptake and turnover was one of the first established functions for endogenous sugar-binding proteins and provides a key model for how glycans can modulate communication between cells in a physiological context. (functionalglycomics.org)
  • These cells present on their surfaces certain receptors named pattern recognition receptors (PRRs), which recognize molecules that are broadly shared by pathogens but distinguishable from host molecules, collectively referred to as pathogen-associated molecular patterns (PAMPs). (academic.ru)
  • The receptors on the cells' surface could be binding the proteins from the bloodstream that coat the particles as they travel through the body, not the particle itself. (utoronto.ca)
  • It is said that not only stimulation through antigen receptors (TCR) but also an additionally stimulative inducement through conjugated stimulative molecular groups (for example, CD28) could be necessary for the activation of T cells. (justia.com)
  • It is reported that PD-1 expression in periphery is observed in myeloid cells including T cells or B lymphocytes activated by stimulation from antigen receptors, or activated macrophages ( International Immunology (1996), vol. 18, issue 5, p. 765-772. (justia.com)
  • competitively antagonizes the cardiac actions of adenosine at the cell surface receptors . (lookformedical.com)
  • 1. Cells in the wall of the collecting duct have membrane receptors for ADH. (goconqr.com)
  • 2. ADH binds to the receptors and cause a series of enzyme-controlled reaction inside the cell. (goconqr.com)
  • Nanoparticles were characterized for encapsulation efficiency, particle size and surface morphology. (ijpsonline.com)
  • Polyethylene glycol-albumin-curcumin nanoparticles showed lesser liver and kupffer cell uptake as compared to that of curcumin-albumin nanoparticles suggesting the bestowment of stealthness to nanoparticles with pegylation. (ijpsonline.com)
  • Proteins on the surface of these cells recognise the nanoparticles and eliminate them. (healthcanal.com)
  • Blocking these proteins means that the endothelial cells will no longer break down the nanoparticles, which then remain in the blood for longer. (healthcanal.com)
  • When this polymer binds to the proteins on the endothelial cells, they no longer recognise the nanoparticles,' he explains. (healthcanal.com)
  • The idea was that by using smaller nanoparticles in combination with the special polymer, there were no more cells in the liver that could remove the nanoparticles. (healthcanal.com)
  • The point in time that Bussmann was certain that the endothelial cells had actually ingested the nanoparticles, was when he administered nanoparticles containing a toxic substance to the fish larvae: this substance only acts within cells and not outside them. (healthcanal.com)
  • So, when only the endothelial cells died, he knew that this was because they had ingested the nanoparticles. (healthcanal.com)
  • We want to understand every step in the process so that we can ultimately produce nanoparticles that can deliver medicines not only to the liver but to every type of cell in the body. (healthcanal.com)
  • When conjugated with targeting ligands such as monoclonal antibodies, peptides or small molecules, these nanoparticles can be used to target malignant tumor cells and the tumor microenvironment (e.g., tumor stroma and tumor vasculatures) with high specificity and affinity. (pubmedcentralcanada.ca)
  • In the 'mesoscopic' size range of 10 to 100 nm, nanoparticles also have large surface areas for conjugating to multiple diagnostic and therapeutic agents, opening up new possibilities in integrated cancer imaging and therapy. (pubmedcentralcanada.ca)
  • After opsonization, the next step is the attachment of phagocytes to nanoparticles via surface-bound proteins. (pubmedcentralcanada.ca)
  • The injected nanoparticles were found in macrophages only, and at moderate exposure primarily in the Kupffer cells in the liver. (biomedcentral.com)
  • Concerning nanoparticles with high stability one might worry about the consequences of introducing matters with such an immense surface area. (biomedcentral.com)
  • Nanoparticles (NPs) may differ in reactivity and solubility and may interact with all kinds of endogenous proteins, lipids, polysaccharides, and cells. (omicsonline.org)
  • To this end, Sefton (BME) is investigating the so-called Kupffer's cells, which are resident immune cells in the liver and thought to be chiefly responsible for sopping up nanoparticles. (utoronto.ca)
  • Other nanoparticles can be loaded with drug molecules and designed to bind to cancer cells. (elifesciences.org)
  • However, we must fully understand how the nanoparticles bind to the cancer cells and how the body tolerates these nanoparticles before they can be used in humans. (elifesciences.org)
  • These maps provide new insights into how cells and tissues in the body handle different nanoparticles. (elifesciences.org)
  • Further experiments show that HSM-AD can reveal interactions between human tumor cells and nanoparticles specifically designed to target those cells. (elifesciences.org)
  • Macrophages have many names, for instance histiocytes, reticuloendothelial cells, Kupffer cells in the liver, littoral cells in the spleen. (thefreedictionary.com)
  • They are regulated by apoptosis, as well as being phagocytized by neighbouring Kupffer cells. (wikipedia.org)
  • In vitro, PGE2 secreted by MSCs inhibited Kupffer cell apoptosis via TLR4-ERK1/2-caspase3 pathway regulation. (springer.com)
  • During this time, the cells migrate from deep in crypts, where they are formed by dividing stem cells , to the surface epithelium where they eventually undergo apoptosis. (siumed.edu)
  • This chapter aims to furnish an overview regarding the physico-chemical properties of M-IONPs (mainly magnetite, maghemite and hematite), the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential mechanism of action-enucleation, apoptosis or other mechanisms. (intechopen.com)
  • The Cell Counting Kit-8 assay and flow cytometry results showed that the [email protected]/miRNA NPs displayed low cytotoxicity and cell apoptosis activity against the KCs. (dovepress.com)
  • In vitro studies on the consequences of antigen presentation (for example, T cell apoptosis) will also be possible. (forschung3r.ch)
  • It also regulates cell growth and differentiation, apoptosis, cell migration, and immune cell function in liver fibrosis/cirrhosis. (intechopen.com)
  • Apoptosis is a key factor in the death of organ-specific cells. (alliedacademies.org)
  • Apoptosis also is an important player in the death of organ-specific cells and in multiorgan failure. (alliedacademies.org)
  • Kupffer cells can produce inflammatory cytokines, TNF-alpha, oxygen radicals, and proteases as well as performing phagocytosis. (wikipedia.org)
  • These functional alterations were accompanied by some histological alterations, like congestion of the central vein, some polymorphonuclear inflammatory cells infiltrate, sinusoids walls showing numerous Kupffer cells with swelling lumen by the blood cells (Figure 5). (thefreedictionary.com)
  • TNF- α is a pleiotropic cytokine, located 850 kb telomeric of class II HLA-DR locus of the short arm of chromosome 6, which induces cellular responses such as proliferation, production of inflammatory mediators, and cell death [ 9 ]. (hindawi.com)
  • Kupffer cells secrete potent mediators of the inflammatory response that control liver inflammation. (thermofisher.com)
  • 7. The method of claim 1 , further comprising administering to the subject a therapeutically effective amount of an anti-infective agent, an anti-inflammatory agent, a bronchodilator, an expectorant, a leukotriene antagonist, or a mast cell stabilizer. (google.com)
  • NASH is an inflammatory disease with complex pathophysiological processes, involving the recruitment of immune cells and the activation of proinflammatory signaling, in which macrophages are key ( 4 ). (frontiersin.org)
  • Liver Kupffer cells have crucial roles in mediating the inflammatory processes that promote liver cancer, but the mechanistic basis for their contributions are not fully understood. (aacrjournals.org)
  • Resident macrophages (Kupffer cells, KCs) in the liver can undergo both pro- or anti-inflammatory activation pathway and exert either beneficiary or detrimental effects on liver metabolism. (biomedcentral.com)
  • In addition, MOMA-1 detects macrophages at inflammatory sites and is po-sitive with Kupffer cells. (acris-antibodies.com)
  • 2) The inflammatory reaction and clearing function of these cells in response to gram negative bacterial products will be studied. (forschung3r.ch)
  • At the onset of an infection, burn, or other injuries, these cells undergo activation (one of their PRR recognize a PAMP) and release inflammatory mediators responsible for the clinical signs of inflammation. (academic.ru)
  • Cytokines produced by macrophages and other cells of the innate immune system mediate the inflammatory response. (academic.ru)
  • trigger the recruitment of inflammatory cells. (academic.ru)
  • Generally, liver fibrosis begins with the stimulation of inflammatory immune cells to secrete cytokines, growth factors, and other activator molecules. (intechopen.com)
  • GNP-treated rats that received 50 μl of 10 and 20 nm particles for 3 or 7 days demonstrated more diffuse interstitial pneumonia, fibrosis, chronic inflammatory cell infiltrates of small lymphocytes, congested and dilated blood vessels, scattered dense extravasation of red blood cells, and foci of hemosiderin granules compared with rats that received 50 μl of 50 nm particles for 3 or 7 days. (omicsonline.org)
  • 75,76) And foam cells , in turn, trigger inflammatory changes in the arterial wall, which eventually lead to the formation of an inflammatory plaque. (thefreedictionary.com)
  • In wild-type mice whose Kupffer cells (but not HSCs) were depleted, fibrosis after injury was similar in mice that received bone marrow transplantations from either TLR4-mutant or wild-type mice, indicating that LPS activation of HSCs (but not Kupffer cells) was important for fibrosis. (sciencemag.org)
  • Adoptive transfer of wild-type Kupffer cells to Trem1 -deficient mice complemented these defects and reversed unresponsiveness to DEN-induced liver injury and malignant development. (aacrjournals.org)
  • Oyama T, Miyazaki M, Yoshimura M, Takata T, Ohjimi H, Jimi S. Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice. (mdpi.com)
  • A and B ) Normotensive and Ang II-induced hypertensive C57BL/6 mice were immunized subcutaneously (s.c.) with OVA-CFA (A) or intraperitoneally (i.p.) with OVA-LPS (B). Seven days later, the percentages and numbers of OVA-specific T cells among total CD8 + T cells in blood (A) and spleen (B) were determined by SIINFEKL-H-2K b tetramer staining. (sciencemag.org)
  • Kupffer cells were isolated from H-2K b -tsA58 transgenic mice. (forschung3r.ch)
  • Dory Daniel, M Letiembre, H. Echchanaouui, F. Ferracin, J. Pieters, Y. Adachi, S. Akashi, R. Landmann (2003) Generation and functional characterization of a clonal murine periportal Kupffer Cell line form H-2K-tsA58 mice. (forschung3r.ch)
  • Kupffer cells have been isolated from transgenic mice carrying a thermolabile SV40 large tumor antigen under the H2Kb promoter (kind gift of D. Kioussis, NIMR, London). (forschung3r.ch)
  • Peritoneal cells from naive mice, 3-day thioglycollate-elicited peritoneal exudate, as well as 4-hour LPS-activated peritoneal cells, contain a population of Mac-1 (CD11b)-high cells which double-stain with rmC5-3 antibody. (fishersci.com)
  • Results Following HBV infection, a complete viral life cycle, with production of HBV DNA, hepatitis B e, core (HBc) and surface (HBs) antigens, and covalently closed circular DNA, was observed in HUHEP and HIS-HUHEP mice. (inserm.fr)
  • Our previous study demonstrated that the combination of mannosylated superoxide dismutase (Man-SOD) and succinylated catalase (Suc-CAT), both of which are designed to be targeted to liver nonparenchymal cells, is a promising approach to prevent the initial phase of hepatic ischemia/reperfusion injury induced by occlusion of the portal vein for 30 min followed by a 1-h reperfusion in mice. (aspetjournals.org)
  • Barsig J, Flesch IE, Kaufmann SH (1998) Macrophages and hepatocytic cells as chemokine producers in murine listeriosis. (springer.com)
  • F4/80 is considered as one of the most specific cell-surface markers for murine macrophages. (miltenyibiotec.com)
  • The cell composition of early hepatic lesions of experimental murine tularemia has not been characterized with specific markers. (asm.org)
  • Single or multiple randomly distributed irregular microabscesses of mononuclear cells and a few neutrophils in the hepatic parenchyma have been seen as early as 1 day postinoculation (DPI) in murine tularemia ( 13 ). (asm.org)
  • It is possible for the Kupffer cells to take in large particles by phagocytosis and smaller particles via pinocytosis. (wikipedia.org)
  • They mediate various cellular responses, such as phagocytosis by macrophages, Ab-dependent cell-mediated cytotoxicity by NK cells, and degranulation of mast cells ( 2 ). (jimmunol.org)
  • These experiments demonstrated that the liver uptake mainly resulted from saturable phagocytosis by Kupffer cells. (aspetjournals.org)
  • A second type of attachment is the nonspecific adherence of phagocytes to surface adsorbed serum proteins, which stimulates phagocytosis [ 30 ]. (pubmedcentralcanada.ca)
  • Phagocytosis of apoptotic and dying cells was evident. (up.ac.za)
  • Interspersed among the many absorptive cells of the intestinal epithelium are scattered goblet cells , occasional enteroendocrine cells (which are difficult to distinguish in routine preparations), and occasional wandering cells of the immune system (e.g., lymphocytes, eosinophils). (siumed.edu)
  • armed m's those capable of inducing cytotoxicity as a consequence of antigen binding by cytophilic antibodies on their surfaces or by factors derived from T lymphocytes . (thefreedictionary.com)
  • macrophages also are involved in cell-mediated immune responses, participate in presenting antigens to lymphocytes, secrete a variety of immunoregulatory molecules, and interact with natural killer cells. (thefreedictionary.com)
  • Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize. (slicksurface.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (slicksurface.com)
  • ConA stimulation significantly increased the rolling velocity of T lymphocytes in postcapillary venules of Peyer's patches, and ConA-stimulated lymphocytes exhibited a loss of the selective adherence properties in Peyer's patches that is normally observed with naive T cells. (physiology.org)
  • Portal tracts were enmeshed by a collagenous network that contained fibroblasts, lymphocytes, plasma cells and phagocytes. (up.ac.za)
  • MSCs exert powerful immunosuppressive functions via paracrine effects and cell-cell contact-dependent interactions, and MSCs also inhibit the proliferation of activated lymphocytes, thereby providing survival signals to resting immune cells and subsequently stimulating the induction of regulatory immune cells [ 12 ]. (biomedcentral.com)
  • plasma cells, lymphocytes, and neutrophils were also noted. (thefreedictionary.com)
  • Constitutive and high expression of F4/80 is found on most resident tissue macrophages, including spleen, microglia in the brain, Kupffer's cells in the liver, and Langerhans cells in the skin. (miltenyibiotec.com)
  • The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. (thermofisher.com)
  • There they complete their differentiation into Kupffer cells. (wikipedia.org)
  • The fate of the vitelline and umbilical veins during the development of the human liver [1] "Differentiation of endodermal cells into hepatoblasts is well studied, but the remodeling of the vitelline and umbilical veins during liver development is less well understood. (edu.au)
  • These findings define Bach2 as a key regulator of antibody response and provide an insight into the orchestration of CSR and SHM during plasma cell differentiation. (labome.org)
  • Hepatocyte- and endothelial cell-derived factors were required to maintain the differentiated phenotype in the Kupffer cell clone, suggesting that a continuous stimulation is required to keep a differentiation state in this cell type. (forschung3r.ch)
  • Galectin-3 is an adhesion molecule and plays an important role in regulation of cell proliferation, differentiation and tumor cell metastasis. (biolegend.com)
  • Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. (slicksurface.com)
  • They may then display the foreign antigen as a warning of the infection to other cells. (sciencephoto.com)
  • Nielsen, Afzelius, Ersbøll, Nielsen, Hansen: Expression of the activation antigen CD69 predicts functionality of in vitro expanded peripheral blood mononuclear cells (PBMC) from healthy donors and HIV-infected patients. (antikoerper-online.de)
  • The set of antigen presenting molecules in the clone allows the consequences of presenting antigens to MHC- and CD1-restricted T cells to be studied. (forschung3r.ch)
  • Contain specialized M cells that take up antigen. (brainscape.com)
  • The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. (thermofisher.com)
  • The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells. (thermofisher.com)
  • Plasma levels of HBV DNA was quantified by quantitative PCR, and antigen-specific antibodies were detected by immunocytochemistry of HBV transfected BHK-21 cells. (inserm.fr)
  • Monoclonal Antibody ( MCA343 ) clone ED3, recognizes the rat CD169 cell surface antigen, a 185 kDa molecule expressed by macrophages predominately confined to lymphoid organs. (bio-rad-antibodies.com)
  • Although KCs have been extensively studied in vitro, little is known of their in vivo response to infection and their capacity to directly interact with antigen-specific CD8 + T cells. (prolekarniky.cz)
  • Our hepatic co-cultures using kupffer cells are powerful new in vitro tools for modeling the liver. (thermofisher.com)
  • The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION. (slicksurface.com)
  • Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. (uniklinik-ulm.de)
  • These cells are difficult to study, however, because they survive and maintain their function only for a short time in vitro. (forschung3r.ch)
  • Unfortunately, freshly isolated Kupffer cells survive and maintain their phenotype only for a short time in vitro. (forschung3r.ch)
  • The goal of this project is to develop a Kupffer cell line suitable for culturing in vitro, so that interactions between these cells and bacteria or bacterial products in vitro may be studied. (forschung3r.ch)
  • Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro. (biomedsearch.com)
  • RESULTS: No in vitro hepatotoxicity in HepG2 cells was seen with infliximab, while concentration-dependent cytotoxicity was observed when HepG2 cells were incubated with increasing concentrations of azathioprine, 6-mercaptopurine and 6-thioguanine. (biomedsearch.com)
  • PD-1 is induced on T cells, B cells, and myeloid cells upon activation in vitro ( 9 ), but predominantly expressed on activated T cells in vivo ( 10 ). (rupress.org)
  • Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. (thermofisher.com)
  • The role of Kupffer cells and reactive oxygen species in hepatic injury during acute and chronic alcohol intoxication. (thefreedictionary.com)
  • These results demonstrate that targeted delivery of antioxidant enzymes to liver nonparenchymal cells is a promising approach to reducing the reactive oxygen species produced by Kupffer cells and neutrophils infiltrating into the tissue. (aspetjournals.org)
  • Gr-1 + Mac-1 + immature myeloid cells and major histocompatibility complex class II-positive (MHC-II + ) Mac-1 + macrophages were the most abundant cell phenotypes found in the granuloma and are likely major contributors in controlling the infection in its early stages. (asm.org)
  • However a number of ED clones are also specific for other cell types such as myeloid cells and reticular elements in secondary lymphoid tissue. (bio-rad-antibodies.com)
  • CD68 staining is predominantly found on the lysosomal membrane of myeloid cells, where there is also weak cell surface expression. (bio-rad-antibodies.com)
  • This may be due to C3-mediated clearance of paroxysmal nocturnal hemoglobinuria red blood cells through the reticuloendothelial system. (haematologica.org)
  • Any of the large phagocytic cells of the reticuloendothelial system. (thefreedictionary.com)
  • See also Kupffer cells , phagocyte , reticuloendothelial system . (thefreedictionary.com)
  • These cells are part of the reticuloendothelial system and are phagocytic and so have an important detoxifying function. (writework.com)
  • Burgio VL, Ballardini G, Artini M, Caratozzolo M, Bianchi FB, Levrero M (1998) Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. (springer.com)
  • Upon release at the basal end of the cell, nutrient molecules diffuse into connective tissue space and eventually into capillaries or lacteals of the lamina propria . (siumed.edu)
  • It is thought that a method of activating T cells could be an effective mean to suprress the function of those conjugated control molecules. (justia.com)
  • 4] for a similar period showed dose- and duration-dependant protective effects, such as diminution of fibrosis and fatty changes, while dilated blood sinusoids, vacuolar degeneration and hypertrophy of Kupffer cells were also seen, when compared to the liver sections of rats intoxicated with [CCl. (thefreedictionary.com)
  • For example, macrophages present in the brain are termed microglia and in the liver sinusoids they are called Kupffer cells. (news-medical.net)
  • Basolateral surface faces sinusoids. (brainscape.com)
  • These epithelial cells are specialized for secretion of mucus, which facilitates passage of material through the bowel. (siumed.edu)
  • Epithelial cells which are specialized to secrete mucus are called mucous cells . (siumed.edu)
  • Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. (slicksurface.com)
  • Kupffer cells (KC), the resident macrophages of the liver, represent the largest population of mononuclear phagocytes in the body. (springer.com)
  • Aono K, Isobe K, Nakashima I, Kondo S, Miyachi M, Nimura Y (1994) Kupffer cells cytotoxicity against hepatoma cells is related to nitric oxide. (springer.com)
  • Nanocarriers, due to their capacity for targeted drug delivery, can shift the balance of cytotoxicity from healthy to cancerous cells. (springer.com)
  • METHODS: Cell survival curves and the half maximal inhibitory concentrations (IC(50)) were obtained after 24, 48 and 72 h of incubation in HepG2 cells with the IBD drugs azathioprine, 6-mercaptopurine, 6-thioguanine, methotrexate or infliximab by using the WST-1 cytotoxicity assay. (biomedsearch.com)
  • It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. (wikipedia.org)
  • Bieghs V, Walenbergh SM, Hendrikx T, van Gorp PJ, Verheyen F, Olde Damink SW et al (2013) Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. (springer.com)
  • Together, our findings offer causal evidence that TREM-1 is a pivotal determinant of Kupffer cell activation in liver carcinogenesis, deepening mechanistic insights into how chronic inflammation underpins the development and progression of liver cancer. (aacrjournals.org)
  • Inflammation is stimulated by chemical factors released by injured cells and serves to establish a physical barrier against the spread of infection, and to promote healing of any damaged tissue following the clearance of pathogens. (academic.ru)
  • Kupffer cells filter bacteria and other foreign proteins from the blood and initiate immune responses. (thefreedictionary.com)
  • The disease evolves from the clonal expansion of hematopoietic stem cells that have a somatic mutation in PIG-A resulting in the partial or complete loss of specific glycosylphosphatidylinositol (GPI)-linked proteins. (haematologica.org)
  • Depending on their surface properties, such as charge and hydrophobicity, nanometer-sized particles have been shown to be 'opsonized' (coated by opsonin proteins) within minutes upon exposure to blood ( Figure 1 ). (pubmedcentralcanada.ca)
  • Recent work by Cedervalli indicates that the initial adsorption of proteins results in a corona that will determine further interactions with other proteins and cells [ 22 ]. (pubmedcentralcanada.ca)
  • Without the presence of surface-bound or adsorbed opsonin proteins, the phagocytes are typically not able to bind or recognize the foreign particles. (pubmedcentralcanada.ca)
  • These antibodies are most commonly IgG, and react with proteins on the surface of red blood cells at normal body temperature (warm agglutinins). (neurologyadvisor.com)
  • CD14 is a 53-55 kDa glycophosphatidylinositol (GPI)-linked glycoprotein belonging to the leucine-rich glycoprotein repeat superfamily of cell-surface proteins. (fishersci.com)
  • Gold NPs (GNPs) can easily enter cells, and the demonstration that amine and thiol groups bind strongly to GNPs has enabled their surface modification with amino acids and proteins for biomedical applications [ 2 , 3 ]. (omicsonline.org)
  • To identify proteins responsible for the expression of heparan sulfate at the apex of polarized cells, we investigated the polarity of the expression of the cell surface heparan sulfate proteoglycans in CaCo-2 cells. (rupress.org)
  • All the facts at your fingertips from cell lineage to marker proteins, discover for yourself. (bio-rad-antibodies.com)
  • The respiratory burst of neutrophils adhering to a biological surface, such as endothelial cells or extracellular matrix proteins, is characterized by a lag-phase of 30 to 90 min between the adherence of activated neutrophils and the subsequent long-lasting ROS formation ( Jaeschke, 1991 ). (aspetjournals.org)
  • 2. Sodium ions are transported into the cell along with glucose or amino acids via co-transporter proteins by facilitated diffusion. (goconqr.com)
  • LDs are cytoplasmic organelles, present in high levels in foam cells , that are comprised by a hydrophobic core of neutral lipids (triglycerides and cholesterol esters) surrounded by a phospholipid monolayer and a growing list of associated proteins [7-9]. (thefreedictionary.com)
  • All mAbs were purified from supernatants from hybridoma cells cultured in RPMI 1640 containing 5% low IgG FCS (Life Technologies, Gaithersberg, MD) on protein A-Sepharose (Pharmacia, Uppsala, Sweden). (jimmunol.org)
  • Micro patterning of cell and protein non-adhesive plasma polymerized coatings for biochip applications. (ncl.edu.tw)
  • Trem1 deficiency attenuated Kupffer cell activation by downregulating transcription and protein expression of interleukin (IL)-6, IL-1β, TNF, CCL2, and CXCL10. (aacrjournals.org)
  • In addition, Trem1 ablation diminished activation of the p38, extracellular regulated kinase 1/2, JNK, mitogen-activated protein kinase, and NF-κB signaling pathways in Kupffer cells, resulting in diminished liver injury after DEN exposure. (aacrjournals.org)
  • Using the zebrafish larvae, Bussmann also discovered precisely which protein in the endothelial cells binds to the particles, namely Stabilin-2. (healthcanal.com)
  • Bussmann also wants to explore how exactly the protein binds to the particles and how the endothelial cells subsequently ingest them. (healthcanal.com)
  • Each of the macrophages have specific protein markers on their surfaces. (news-medical.net)
  • Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian cells. (uniklinik-ulm.de)
  • Both are members of the lysosomal-associated membrane protein (lamp) family which are located predominantly within the cells and can be detected by flow cytometry using cell permeabilisation. (acris-antibodies.com)
  • This property may offer the possibility of identifying which factors modulate gene and protein expression in Kupffer cells and to study interactions with other liver or blood cells. (forschung3r.ch)
  • Total cell lysates (15 µg protein) from NIH3T3 (lane 1), HT29 (lane 2) and 293E (lane 3) cells were resolved by electrophoresis (4-20% Tris-Glycine gel), transferred to nitrocellulose, and probed with 1 µg/mL (1:500 dilution) of purified anti-mouse/human Galectin-3 (Mac-2) antibody (clone Gal397) (upper blot). (biolegend.com)
  • What is the role of a long-mysterious protein particle in cells? (utoronto.ca)
  • Yet, most of this proteoglycan was expressed at the basolateral surface, an unexpected finding for a glypiated protein. (rupress.org)
  • The fluorescent protein reporter of the Akmlc2f promoter, pDsRed2-1/Akmlc2f P2657 was digested with the restriction endonuclease Apa LI and then the DNA solution at concentrations of 25 ng/mL was injected into the one-cell stage embryos using an air-pressure microinjector (WPI). (bioz.com)
  • Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. (wikipedia.org)
  • The surface of Kupffer cells contain microvilli, pseudopodia and lamellipodia, which project in every direction. (wikipedia.org)
  • The apical surface area of each absorptive cell is greatly increased by evagination into a dense array of microvilli , visible microscopically as the brush border . (siumed.edu)
  • Central bile canaliculi contained microvilli originating from apical hepatocyte surfaces and were sealed off by junctional complexes. (up.ac.za)
  • Gut bacteria, bacterial endotoxins, and microbial debris transported to the liver from the gastrointestinal tract via the portal vein will first come in contact with Kupffer cells, the first immune cells in the liver. (wikipedia.org)
  • Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines . (academic.ru)
  • These activated cells secrete antiviral cytokines which is thought to be central in suppression or clearance of HBV from the infected liver [ 4 ]. (hindawi.com)
  • Breiner KM, Schaller H, Knolle PA (2001) Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms. (springer.com)
  • The scavenger endothelial cell - a new player in homeostasis and immunity. (uio.no)
  • Four cell lines were cultured at 33ºC in a medium containing interferon-gamma and the supernatants from cell lines of hepatocyte and endothelial cell cultures. (forschung3r.ch)
  • They locally proliferate, they are usually a susceptible population of phagocytic cells. (wikipedia.org)
  • Kupffer cells play an active role in the remodeling and maintenance of liver extracellular matrix. (thermofisher.com)
  • TNF- α is produced mainly by macrophages and also by a broad variety of other cell types including lymphoid cells, mast cells, endothelial cells, fibroblasts, and neurons [ 9 ]. (hindawi.com)
  • An understanding on the specificities of a protective B cell response, the molecular locations of these epitopes on E1, E2, and E1E2, and the mechanisms, which enable the virus to negatively modulate neutralizing antibody responses to these regions will provide the necessary guidance for vaccine design. (frontiersin.org)
  • ER-MP20 antibody also detects a wide range of endothelial cells. (acris-antibodies.com)
  • CD68 antibody clone FA-11 detects surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycolate stimulation. (acris-antibodies.com)
  • Activation of the complement cascade to identify bacteria, activate cells and to promote clearance of dead cells or antibody complexes . (academic.ru)
  • Total cell lysate from MCF7 cells (lane 1, 15 µg), Jurkat cells (lane 2, 15 µg), 3T3-L1 (lane 3, 15 µg) and Raw264.7 (lane 4, 15 µg) were resolved by electrophoresis (4-20% Tris-Glycine gel), transferred to nitrocellulose, and probed with purified anti-mouse/human Galectin-3 (Mac-2) antibody (clone Gal397). (biolegend.com)
  • HeLa cells were stained with purified anti-Galectin 3 (Gal397) antibody, followed by staining with DyLight™ 594 conjugated goat anti-mouse IgG (red) antibody. (biolegend.com)
  • Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. (miltenyibiotec.com)
  • Applications Tested: This BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. (thermofisher.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
  • Monoclonal Antibody ( MCA342 ) clone ED2, recognizes CD163, a 175 kDa cell surface glycoprotein present on resident rat macrophages. (bio-rad-antibodies.com)
  • This antibody is a useful tool for staining synovial lining and Kupffer cells in the liver. (bio-rad-antibodies.com)
  • Immunostaining of Kupffer cells in the liver and foam cells in the liver and the hepatic lymph node for MAC 387 antibody proved that these cells are macrophages. (thefreedictionary.com)
  • LPS- induced activation of NF-κB1p105-MEK-ERK pathway is significantly enhanced in the GRK2▵mye macrophages compared to GRK2fl/fl cells and importantly, inhibition of the p105 and ERK pathways in the GRK2▵mye macrophages, limits the enhanced production of LPS- induced cytokines/chemokines. (lookformedical.com)
  • Growing evidence (1-7) shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). (thermofisher.com)
  • Kupffer cell cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. (thermofisher.com)
  • IL6 production in Kupffer cells and hepatocyte co-cultures after LPS and IL2 stimulation for 24, 48 and 72 hrs. (thermofisher.com)
  • Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function. (thermofisher.com)
  • Mononuclear cells were isolated from spleen and liver for analysis by flow cytometry. (inserm.fr)
  • Here, using a combination of approaches including whole mount and thin section confocal microscopy, adoptive cell transfer and intra-vital 2-photon microscopy, we demonstrate that KCs represent the only detectable population of mononuclear phagocytes within granulomas induced by Leishmania donovani infection that are capable of presenting parasite-derived peptide to effector CD8 + T cells. (prolekarniky.cz)
  • Kupffer cells (KCs), first identified in 1876, are now recognised as the major population of mononuclear phagocytes to inhabit the resting liver. (prolekarniky.cz)
  • The absence of PD-1 induced proliferation of effector T cells in the adenovirus-infected liver and resulted in rapid clearance of the virus. (rupress.org)
  • These results indicate that PD-1 plays an important role in T cell tolerance at the effector phase and the blockade of the PD-1 pathway can augment antiviral immunity. (rupress.org)
  • When naive T cells differentiate into effector cells, they change their activation requirement. (rupress.org)
  • Effector T cells are much less dependent on costimulation than naive T cells. (rupress.org)
  • Effector T cells, unlike naive T cells, can be activated by TCR signal alone ( 2 , 3 ). (rupress.org)
  • A more perplexing and less easily understandable observation is that effector T cells can be activated by costimulatory signal in the absence of TCR signal ( 4 , 5 ). (rupress.org)
  • As effector T cells can be easily activated, their negative regulatory system should play vital roles in the maintenance of peripheral tolerance. (rupress.org)
  • Nevertheless, little is known about the mechanism that prevents undesirable or excessive activation of effector T cells in the periphery. (rupress.org)
  • HBV-infected HIS-HUHEP livers contained infiltrating Kupffer cells, mature activated natural killer cells (CD69+), and PD-1+ effector memory T cells (CD45RO+). (inserm.fr)
  • In joint research carried out with the Hubrecht Institute and the University of Basle, Jeroen Bussmann, chemical biologist at Leiden University, discovered that cells in the blood vessel walls of the liver (endothelial cells) often play a much greater role in this process. (healthcanal.com)
  • have walls of endothelial cells that overlap like shingles. (coursehero.com)
  • Posing another threat are foam cells , which may live in the walls of the arteries, contributing to atherosclerosis. (thefreedictionary.com)
  • In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology. (rupress.org)
  • MRSA count was the highest in the liver, especially within Kupffer cells, which were positive for acid polysaccharides that are associated with intracellular biofilm. (mdpi.com)
  • Insulin is known to cause a rapid and marked stimulation of iron uptake by fat cells, redistributing TfRs from an intracellular membrane compartment to the cell surface ( 2 ). (diabetesjournals.org)
  • Kupffer cells (KCs) represent the major phagocytic population within the liver and provide an intracellular niche for the survival of a number of important human pathogens. (prolekarniky.cz)
  • As expected, following activation with LPS treatment, IL6 production is significantly up-regulated at 24 hrs and then progressively decreases, suggesting desensitization of Kupffer cells to chronic stimulation with LPS. (thermofisher.com)
  • She is tracking the chronic viral infection in individual woodchuck liver cells at different stages of disease to capture how tumours change over time. (utoronto.ca)
  • Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF et al (2003) Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. (springer.com)
  • TNF- is a pleiotropic cytokine that has biological effects ranging from cell death to inducing tissue regeneration [ 11 - 13 ]. (hindawi.com)
  • This non-destructive technique quantitatively identifies particles in ex vivo tissue sections and enables detailed observations of accumulation patterns arising from organ-specific clearance mechanisms, particle size, and the molecular specificity of nanoparticle surface coatings. (elifesciences.org)
  • IL6 production in Kupffer cells after LPS and IL2 stimulation for 24, 48 and 72 hrs. (thermofisher.com)
  • The clone can be transfected and used to analyze signaling in Kupffer cells after stimulation with bacteria or bacterial products. (forschung3r.ch)
  • Bile produced by liver cells drains into microscopic canals known as bile canaliculi. (innerbody.com)
  • A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. (slicksurface.com)
  • We succeeded for the first time in generating a stable, clonal Kupffer cell line. (forschung3r.ch)
  • these cells are widely distributed in the body and vary in morphology and motility, although most are large, long-lived cells with nearly round nuclei and abundant endocytic vacuoles, endosomes, lysosomes, and phagolysosomes. (thefreedictionary.com)
  • There are mainly two types of hepatic macrophages: Kupffer cells, that reside in the liver and originated from yolk sac-derived red bone marrow progenitor cells, and also monocyte-derived macrophages, derived from hematopoietic stem cells from the bone marrow and transported through the blood circulation to the liver. (wikipedia.org)
  • Secondly, as a haemopoietic tissue where blood stem cells reside before bone marrow development. (edu.au)
  • All blood cells are manufactured by stem cells, which live mainly in the bone marrow, via a process called hematopoiesis . (hartford.edu)
  • Absorptive cells , or enterocytes , are the predominant epithelial cell type lining the lumen of the small intestine and colon . (siumed.edu)
  • Both the centrilobular and periportal regions of the liver, house Kupffer cells, but their function and structures change depending on their location. (wikipedia.org)
  • Periportal Kupffer cells tend to be larger and have more lysosomal enzyme and phagocytic activity, whereas centrilobular Kupffer cells create more superoxide radical. (wikipedia.org)
  • The large size of the cells, their pattern of surface marker expression and their capacity to clear Gram-negative and -positive bacteria indicate that the clone was derived from the periportal large Kupffer cell subpopulation. (forschung3r.ch)
  • Lipopolysaccharide (LPS) is a bacterial endotoxin which is found in the cell wall gram-negative bacteria, whereas lipoteichoic acid is present in gram-positive bacteria. (wikipedia.org)
  • Apart from clearing any bacteria, red blood cells are also broken down by phagocytic action, where the hemoglobin molecule is split. (wikipedia.org)
  • Rather, the lesions are largely composed of two subpopulations of Mac-1 + cells that are associated with the bacteria. (asm.org)
  • [ 4 ] Desquamation of skin epithelium also helps remove bacteria and other infectious agents that have adhered to the epithelial surfaces. (academic.ru)
  • [ 4 ] The gut flora can prevent the colonization of pathogenic bacteria by secreting toxic substances or by competing with pathogenic bacteria for nutrients or attachment to cell surfaces. (academic.ru)
  • This process enables naive cells to increase the frequency of encounters with cognate antigens ( 9 , 26 ). (physiology.org)
  • The grouping is characterized by the presence or absence of A and/or B antigens on the surface of the RBCs. (hartford.edu)
  • ConA activation also suppressed the accumulation of T cells in the spleen. (physiology.org)
  • cells were isolated from spleen single-cell suspension using Anti-F4/80 MicroBeads UltraPure, two MS Columns, and an OctoMACS™ Separator. (miltenyibiotec.com)
  • In vivo Drug release, tissue uptake and kupffer cell uptake was determined with optimized nanoformulation in rats after intravenous administration. (ijpsonline.com)
  • developed novel pH responsive micelles for oral curcumin delivery and demonstrated enhanced uptake of the formulation into cervical cells[ 5 ]. (ijpsonline.com)
  • Current gene delivery methods often result in low cellular uptake efficiency in vivo in some types of cells, especially for the Kupffer cells (KCs). (dovepress.com)
  • They are also useful in removing apoptotic cells from circulation. (wikipedia.org)
  • The first oncolytic adenoviral mutant to be evaluated in pancreatic cancer patients was Onyx-015 ( dl 1520) with deletion of the E1B55K gene enabling virus propagation in cancer cells with aberrant nuclear mRNA export and nonfunctional p53 ( 3-5 ). (aacrjournals.org)
  • We use and develop techniques for viral and non-viral gene transfer (vectors), which allow to efficiently introduce nucleic acids (DNA, RNA) into body cells. (uniklinik-ulm.de)
  • Xie (Mogen) is combining volumetric electron microscopy with gene expression data from liver cells to map the organ down to nano-meter resolution. (utoronto.ca)
  • In routine light microscopy, mucous cells are most conspicuously distinguished by their 'empty' appearance (i.e., poorly stained cytoplasm) and densely-stained, basal nuclei. (siumed.edu)
  • The stem cells produce hemocytoblasts that differentiate into the precursors for all the different types of blood cells. (hartford.edu)
  • No. X67914, and those expression are observed when thymus cells differentiate from CD4-CD8− cell into CD4+CD8+ cell (International Immunology (1996), vol. 18, issue 5, p. 773-780, Journal of Experimental Medicine (2000), vol. 191, issue 5, p. 891-898. (justia.com)
  • Thy1 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (genetex.com)
  • We conclude that, at least in K562 cells, syndecans and glypican can support bFGF-FGFR1 interactions and signaling, and that cell-surface association may augment their effectiveness. (rupress.org)
  • Kupffer cells contain the largest amount of tissue-resident macrophages in the body. (wikipedia.org)