Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.
INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).
Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.
Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.
Sesquiterpenes are a class of terpenes consisting of three isoprene units, forming a 15-carbon skeleton, which can be found in various plant essential oils and are known for their diverse chemical structures and biological activities, including anti-inflammatory, antimicrobial, and cytotoxic properties.
A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

The pharmacokinetics of artemisinin after administration of two different suppositories to healthy Vietnamese subjects. (1/129)

Eight healthy Vietnamese male subjects received 400 mg artemisinin formulated into fatty suppositories (FS), and six different subjects received 500 mg of artemisinin formulated in polyethylene glycol suppositories (PEGS). Plasma concentrations were measured by high-performance liquid chromatography with electrochemical detection; concentration versus time curves were analyzed with nonparametric methods. No statistically significant differences were found between the two formulations. The maximum concentration (Cmax) was 100 +/- 102 microg/L (mean +/- SD, range = 24-330) microg/L (FS), the pharmacokinetic lag time (Tlag) was 1.3 +/- 1.0 hr (range = 0-3) (FS), and the time of the maximum concentration (Tmax) was 7.1 +/- 2.1 hr (range = 3-10) hr (FS). Because artemisinin is not available for intravenous dosage, absolute bioavailability cannot be assessed. However, compared with a previous study on oral artemisinin in healthy Vietnamese subjects, bioavailability relative to oral administration was estimated to be approximately 30%. We conclude that therapeutic blood concentrations of artemisinin can be reached after rectal dosage. The dose after rectal administration should probably be higher than after oral administration; doubling or tripling the oral dose might be necessary, which would imply a rectal dose of at least 20 mg/kg of body weight given twice a day.  (+info)

Efficacy of promethazine suppositories dispensed to outpatient surgical patients. (2/129)

Postoperative nausea and vomiting frequently complicate outpatient anesthesia and surgery. The duration of treatment for this complication must occasionally extend beyond discharge from the hospital. In this study, we evaluated the commonly used anti-emetic promethazine for its efficacy in the post-discharge period. Adult outpatient surgical patients who had excessive postoperative nausea and vomiting in the recovery room, or who were at risk for postoperative nausea and vomiting following discharge were given two promethazine suppositories (25 mg) for home use. All patients were contacted by our recovery room nurses on the first business day after their surgery and questioned as to their use of the suppositories and, if used, their efficacy. We found that 55 percent of patients given promethazine suppositories for home use had nausea and vomiting in the post-discharge period. Of the patients given promethazine, 89 percent used the suppositories. All of these patients reported improvement in their symptoms following use of the suppositories. None reported adverse effects from the promethazine suppositories. In conclusion, we found promethazine suppositories to be an inexpensive and efficacious treatment for nausea and vomiting in adult outpatient surgical patients following discharge from the hospital. Side-effects were minimal, and our patients voiced no complaints about this mode of therapy. We recommend this therapy for treatment of nausea and vomiting after hospital discharge following adult outpatient surgery.  (+info)

Rectal paracetamol has a significant morphine-sparing effect after hysterectomy. (3/129)

We have evaluated the morphine-sparing effect of rectal paracetamol during the first 24 h after abdominal hysterectomy in a placebo-controlled, double-blind study. We studied 72 patients receiving patient-controlled analgesia (PCA) with i.v. morphine after a standardized anaesthetic, allocated randomly to receive rectal paracetamol 1.3 g, diclofenac 50 mg or placebo, after wound closure and at 8 and 16 h. Suppositories were blinded by the hospital pharmacy. Study violations excluded data from seven patients. Patient data, morphine doses during anaesthesia and recovery, and sedation and nausea scores were comparable. Mean morphine consumption during PCA was 35.0 (SD 20.4) mg, 32.7 (27.4) mg and 54.9 (28.3) mg in the paracetamol (n = 24), diclofenac (n = 20) and placebo (n = 21) groups, respectively (P < 0.05). Morphine sparing during PCA for paracetamol and diclofenac (36% vs 40% over 24 h) was significant from 4 h. Global scores of average pain over 24 h were lower after diclofenac compared with paracetamol (P < 0.01) and placebo (P = 0.08). We conclude that rectal paracetamol was an efficacious adjuvant analgesic after regular dosing.  (+info)

Improving the view in the rectal clinic: a randomised control trial. (4/129)

BACKGROUND: Rigid sigmoidoscopy forms an integral part of the out-patient assessment of patients with colorectal symptoms. However, the value of this of this examination is often diminished by faecal loading of the rectum. This trial aimed to determine the ability of a single self-administered glycerine suppository to clear the rectum in preparation for rigid sigmoidoscopy, and considered patient acceptability of this practice. METHODS: Consecutive patients were randomly allocated to receive suppository or no suppository prior to out-patient rigid sigmoidoscopy. Assessment was made of patient compliance, the effectiveness of rectal examination, and the depth to which the sigmoidoscope was inserted. RESULTS: 131 patients were randomised into suppository (n = 66) or control groups (n = 65). The number of patients deemed to have good views of the rectum (> 75% of rectal mucosa seen) was significantly greater in suppository than control groups (79% versus 26.2%, P < 0.05 Chi square test), whilst that of poor examinations (< 50% of rectal mucosa seen) was significantly greater in control than suppository groups (44.6% versus 4%, P < 0.05). The depth of insertion of the sigmoidoscope was significantly greater in those receiving suppositories (54.5% versus 21.5% undergoing evaluation to 18 cm or more, P < 0.05). Compliance amongst those who received suppositories was high with only 3 of 53 (4.5%) patients in the suppository group evaluated by questionnaire reporting difficulty or concerns over their use. CONCLUSION: Self-administered suppositories are acceptable to patients and significantly improve the efficiency of outpatient rigid sigmoidoscopy. Their usage should become routine.  (+info)

Pharmacokinetics of rectal paracetamol after repeated dosing in children. (5/129)

Twenty-three children (aged between 9 weeks and 11 yr) were given paracetamol suppositories 25 mg kg-1 every 6 h (maximum 5 days) after major surgery and serum and saliva concentrations were measured. There was a good correlation (r = 0.91, P < 0.05) between saliva and serum concentrations. A one-compartment linear model with first-order elimination and absorption and lag-time was fitted to the data (ADAPT II). At steady state, the mean (SD) concentration was 15.2 (6.8) mg litre-1. Mean (SD) time to reach 90% of the steady state concentration was 11.4 (8.6) h. Body weight, age and body surface area were well correlated (P < 0.05) with clearance and apparent volume of distribution. There was no evidence of accumulation leading to supratherapeutic concentrations during this dosing schedule for a mean of approximately 2-3 days.  (+info)

An unexpected benefit of pre-emptive rectal analgesic administration: the "key" to postoperative analgesia. (6/129)

Analgesic and anti-inflammatory drugs are frequently administered intraoperatively by the rectal route to provide pre-emptive postoperative analgesia. We report the case of an inmate of a federal penitentiary who underwent orthopedic surgery in a public hospital. After induction of general anesthesia, indomethacin and acetaminophen were administered rectally. This led to the incidental discovery of a handcuff key hidden in the rectum and, thereby, the prevention of a planned escape. A review of data regarding escapes by prisoners from public hospitals is provided, as well as a description of cases of patients presenting with foreign rectal objects. A number of benefits have been described for the use of pre-emptive analgesia. This is the first reported description of an incidental benefit: the prevention of a planned escape by a prison inmate.  (+info)

The suppository form of antibiotic administration: pharmacokinetics and clinical application. (7/129)

The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can provide satisfactory pharmacokinetics and acceptable local tolerance. Experiments in animals have demonstrated the influence of the pharmaceutical formulation of suppositories on the rectal absorption and systemic distribution of beta-lactams and aminoglycosides. In healthy volunteers and in children under treatment, similar adjuvants--mainly glyceride mixtures or non-ionic surface agents--have increased the rectal absorption of aminopenicillins, cephalosporins and macrolides. Other antibiotics, including metronidazole and cotrimoxazole, have been investigated in respect of their potential rectal administration.  (+info)

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs. (8/129)

The effects on intraluminal pressure in the oesophagus, the cardiac sphincter, and the gastric fundus of intravenous prostaglandin F2alpha, E2, And of rectal indomethacin were studies in 41 subjects. Intravenous infusion of prostaglandin F2alpha (0-05 to 0-8 mug kg-minus1) produced marked, dose-related and sustained elevation of cardiac sphincter pressure without significantly affecting oesophageal peristalsis or gastric fundal motility. Sphincteric relaxation during swallowing was prolonged. Plasma gastrin levels were unchanged. Intravenous infusion of PGE2 (0-08 mug kg-minus1 min-minus) inhibited sphincter contractions to serial bolus intravenous injections of pentagastrin (0-1 or 0-2 mug kg-minus 1). Rectal indomethacin (200 mg) resulted in a riseof cardiac sphincter pressure, suggesting that endogenous synthesis of an inhibitory (E-type) prostaglandin was suppressed. The results indicate that prostaglandin E2 may be concerned in the regulation of cardiac sphincter tone in man, whilst prostaglandin F2alpha may be useful in the treatment of gastrooesphageal reflux.  (+info)

A suppository is a solid medicinal formulation, often medicated, that is intended to be introduced into the rectum (rectal suppository), vagina (vaginal suppository), or urethra (urethral suppository) for absorption or for localized effect. Suppositories are designed to melt or dissolve at body temperature and release the active ingredients. They come in various shapes, such as cones, cylinders, or torpedo-shaped, and are typically made from a base of cocoa butter, polyethylene glycol, or other biocompatible materials that allow for controlled drug release. Common uses for suppositories include the treatment of constipation, hemorrhoids, local infections, menstrual cramps, and as an alternative method of administering medication for individuals who have difficulty swallowing pills or prefer not to use oral medications.

"Administration, Rectal" is a medical term that refers to the process of administering medication or other substances through the rectum. This route of administration is also known as "rectal suppository" or "suppository administration."

In this method, a solid dosage form called a suppository is inserted into the rectum using fingers or a special applicator. Once inside, the suppository melts or dissolves due to the body's temperature and releases the active drug or substance, which then gets absorbed into the bloodstream through the walls of the rectum.

Rectal administration is an alternative route of administration for people who have difficulty swallowing pills or liquids, or when rapid absorption of the medication is necessary. It can also be used to administer medications that are not well absorbed through other routes, such as the gastrointestinal tract. However, it may take longer for the medication to reach the bloodstream compared to intravenous (IV) administration.

Common examples of rectally administered medications include laxatives, antidiarrheal agents, analgesics, and some forms of hormonal therapy. It is important to follow the instructions provided by a healthcare professional when administering medication rectally, as improper administration can reduce the effectiveness of the medication or cause irritation or discomfort.

Ointment bases refer to the vehicle or foundation in which active pharmaceutical ingredients are dispersed to form a semi-solid medication. These bases provide the necessary consistency for ointments, allowing easy application to the skin or other body surfaces. They can be composed of various materials such as fats, waxes, oils, and emulsifying agents.

The choice of an ointment base depends on several factors, including:

1. The desired physical properties (e.g., spreadability, absorption rate)
2. The route of administration (e.g., dermal, mucosal)
3. The compatibility with the active ingredient(s)
4. The intended therapeutic effect (e.g., occlusive, non-occlusive)

Some common types of ointment bases include:

1. Hydrocarbon bases: Consist of hydrophobic materials like petrolatum, white soft paraffin, and microcrystalline wax. They are generally inert, odorless, and resistant to oxidation.
2. Absorption bases: Contain a mixture of hydrocarbons and higher molecular weight esters or fatty alcohols. These bases have better penetrating properties than hydrocarbon bases and are suitable for drugs with low oil solubility.
3. Emulsifying bases: Comprise of water-in-oil (W/O) or oil-in-water (O/W) emulsions, which allow the dispersion of both hydrophilic and lipophilic drugs. Common examples include cetomacrogol and anhydrous lanette.
4. Water-soluble bases: Primarily consist of polyethylene glycols (PEGs) or other water-soluble materials. They are useful for drugs with high water solubility and provide a cooling sensation upon application.

It is essential to select an appropriate ointment base to ensure the optimal delivery, stability, and efficacy of the active ingredient(s).

Proctitis is a medical condition that refers to inflammation of the lining of the rectum, which is the lower end of the colon. The symptoms of proctitis may include rectal pain, discomfort, or a feeling of fullness; rectal bleeding, often in the form of mucus or blood; diarrhea; and urgency to have a bowel movement.

Proctitis can be caused by a variety of factors, including infections (such as sexually transmitted infections, foodborne illnesses, or inflammatory bowel diseases like Crohn's disease or ulcerative colitis), radiation therapy, trauma, or autoimmune disorders. The diagnosis of proctitis typically involves a physical examination, medical history, and sometimes endoscopic procedures to visualize the rectum and take tissue samples for further testing. Treatment depends on the underlying cause but may include antibiotics, anti-inflammatory medications, or other therapies.

Butylscopolammonium Bromide is an anticholinergic drug, which is used as a smooth muscle relaxant and an anti-spasmodic agent. It works by blocking the action of acetylcholine, a neurotransmitter in the body, on certain types of receptors, leading to relaxation of smooth muscles and reduction of spasms.

This medication is commonly used to treat gastrointestinal disorders such as irritable bowel syndrome, intestinal cramps, and spastic constipation. It may also be used in the management of bladder disorders, including neurogenic bladder and urinary incontinence.

The drug is available in various forms, including tablets, suppositories, and solutions for injection. The dosage and route of administration depend on the specific condition being treated and the patient's overall health status. As with any medication, Butylscopolammonium Bromide can cause side effects, such as dry mouth, blurred vision, dizziness, and constipation. It should be used under the guidance of a healthcare professional to ensure safe and effective treatment.

Laxatives are substances or medications that are used to promote bowel movements or loosen the stools, thereby helping in the treatment of constipation. They work by increasing the amount of water in the stool or stimulating the muscles in the intestines to contract and push the stool through. Laxatives can be categorized into several types based on their mechanism of action, including bulk-forming laxatives, lubricant laxatives, osmotic laxatives, saline laxatives, stimulant laxatives, and stool softeners. It is important to use laxatives only as directed by a healthcare professional, as overuse or misuse can lead to serious health complications.

Mesalamine is an anti-inflammatory drug that is primarily used to treat inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease. It works by reducing inflammation in the intestines, which can help alleviate symptoms like diarrhea, abdominal pain, and rectal bleeding.

Mesalamine is available in various forms, including oral tablets, capsules, suppositories, and enemas. The specific formulation and dosage may vary depending on the severity and location of the inflammation in the gut.

The drug's anti-inflammatory effects are thought to be mediated by its ability to inhibit the activity of certain enzymes involved in the inflammatory response, such as cyclooxygenase and lipoxygenase. By reducing inflammation, mesalamine can help promote healing and prevent recurrences of IBD symptoms.

It's important to note that mesalamine may cause side effects, including headache, nausea, vomiting, and abdominal pain. In rare cases, it may also cause more serious side effects like kidney damage or allergic reactions. Patients should talk to their healthcare provider about the potential risks and benefits of taking mesalamine.

Benzocaine is a local anesthetic agent that works by numbing the skin or mucous membranes to block pain signals from reaching the brain. It is commonly used as a topical medication in the form of creams, gels, sprays, lozenges, and ointments to relieve pain associated with minor cuts, burns, sunburn, sore throat, mouth ulcers, and other conditions that cause discomfort or irritation.

Benzocaine works by temporarily reducing the sensitivity of nerve endings in the affected area, which helps to alleviate pain and provide a soothing effect. It is generally considered safe when used as directed, but it can have some side effects such as skin irritation, stinging, burning, or allergic reactions.

It's important to note that benzocaine products should not be used on deep wounds, puncture injuries, or serious burns, and they should not be applied to large areas of the body or used for prolonged periods without medical supervision. Overuse or misuse of benzocaine can lead to rare but serious side effects such as methemoglobinemia, a condition that affects the oxygen-carrying capacity of the blood.

Sesquiterpenes are a class of terpenes that consist of three isoprene units, hence the name "sesqui-" meaning "one and a half" in Latin. They are composed of 15 carbon atoms and have a wide range of chemical structures and biological activities. Sesquiterpenes can be found in various plants, fungi, and insects, and they play important roles in the defense mechanisms of these organisms. Some sesquiterpenes are also used in traditional medicine and have been studied for their potential therapeutic benefits.

"Pharmaceutical vehicles" is not a standard term in medical or pharmaceutical sciences. However, I can provide some context based on the phrase's possible meaning. If by "pharmaceutical vehicles," you mean the carriers or delivery systems for drugs or medications, then the definition would be:

Pharmaceutical vehicles refer to various formulations, preparations, or technologies that facilitate and control the administration of a drug or therapeutic agent to its target site in the body. These can include different types of drug delivery systems such as tablets, capsules, liposomes, nanoparticles, transdermal patches, inhalers, injectables, and other innovative drug carrier technologies.

These pharmaceutical vehicles ensure that the active ingredients are safely and effectively transported to their intended site of action within the body, enhancing therapeutic efficacy while minimizing potential side effects.

The rectum is the lower end of the digestive tract, located between the sigmoid colon and the anus. It serves as a storage area for feces before they are eliminated from the body. The rectum is about 12 cm long in adults and is surrounded by layers of muscle that help control defecation. The mucous membrane lining the rectum allows for the detection of stool, which triggers the reflex to have a bowel movement.

Promethazine is an antihistamine and phenothiazine derivative, which is commonly used for its sedative, anti-emetic (prevents vomiting), and anti-allergic properties. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and by blocking the action of dopamine, a neurotransmitter in the brain that helps transmit signals.

Promethazine is used to treat various conditions such as allergies, motion sickness, nausea and vomiting, and as a sedative before and after surgery or medical procedures. It may also be used for its calming effects in children with certain behavioral disorders.

Like all medications, promethazine can have side effects, including drowsiness, dry mouth, blurred vision, and dizziness. More serious side effects may include seizures, irregular heartbeat, and difficulty breathing. It is important to follow the instructions of a healthcare provider when taking promethazine and to report any unusual symptoms or side effects promptly.

Drug compounding is the process of combining, mixing, or altering ingredients to create a customized medication to meet the specific needs of an individual patient. This can be done for a variety of reasons, such as when a patient has an allergy to a certain ingredient in a mass-produced medication, or when a patient requires a different dosage or formulation than what is available commercially.

Compounding requires specialized training and equipment, and compounding pharmacists must follow strict guidelines to ensure the safety and efficacy of the medications they produce. Compounded medications are not approved by the U.S. Food and Drug Administration (FDA), but the FDA does regulate the ingredients used in compounding and has oversight over the practices of compounding pharmacies.

It's important to note that while compounding can provide benefits for some patients, it also carries risks, such as the potential for contamination or incorrect dosing. Patients should only receive compounded medications from reputable pharmacies that follow proper compounding standards and procedures.

Artemisinins are a class of antimalarial drugs derived from the sweet wormwood plant (Artemisia annua). They are highly effective against Plasmodium falciparum, the most deadly species of malaria parasite. Artemisinins have become an essential component in the treatment of malaria and are often used in combination therapy regimens to reduce the risk of drug resistance.

The artemisinin compounds contain a unique peroxide bridge that is responsible for their antimalarial activity. They work by generating free radicals that can damage the parasite's membranes, leading to its rapid death. Artemisinins have a fast action and can significantly reduce the parasite biomass in the first few days of treatment.

Some commonly used artemisinin-based combination therapies (ACTs) include:

* Artemether-lumefantrine (Coartem)
* Artesunate-amodiaquine (Coarsucam)
* Artesunate-mefloquine (Artequin)
* Dihydroartemisinin-piperaquine (Eurartesim, Duo-Cotecxin)

Artemisinins have also shown potential in treating other conditions, such as certain types of cancer and viral infections. However, more research is needed to establish their safety and efficacy for these indications.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever. It works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. Diclofenac is available in various forms, including tablets, capsules, suppositories, topical creams, gels, and patches.

The medical definition of Diclofenac is:

Diclofenac sodium: A sodium salt of diclofenac, a phenylacetic acid derivative that is a potent inhibitor of prostaglandin synthesis. It is used in the treatment of inflammation and pain in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other conditions. Diclofenac sodium has also been used to treat actinic keratosis, a precancerous skin condition. It is available by prescription in various forms, including oral tablets, capsules, topical creams, gels, and patches.

These suppositories are given rectally due to the risk of death from severe malaria, as described below. The risk of death from ... Artesunate suppositories are used for the treatment of malaria. Artesunate is an antimalarial water-soluble derivative of ... The drug artesunate, given in rectal suppository form, provides a potential solution to this problem: it can be made available ... Significant work with artemisinin suppositories in severe malaria was conducted in Viet Nam in the early 1990s, and clinical ...
... rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a ... The type of material used depends on the type of suppository, the type of drug, and the conditions in which the suppository ... Wikimedia Commons has media related to: Suppository (category) Artesunate suppositories Enema Pessary Jannin, Vincent; Lemagnen ... A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to ...
... suppositories, and rings; rectal suppositories; oil solutions for intramuscular injection; and aqueous solutions for ... A progesterone suppository which is marketed under the brand name Cyclogest is indicated for rectal administration in addition ... Rectal progesterone suppositories were first studied in men and women by Christian Hamburger in 1965. Vaginal and rectal ... It is also available in the form of vaginal or rectal suppositories or pessaries, topical creams and gels, oil solutions for ...
"NetDoctor: Proctosedyl ointment/suppositories". Retrieved 2009-01-21. Maan MS, Mishra R, Thomas S, Hadke NS (2004). "Randomized ... One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by ... Both the yellowish-white, translucent, greasy ointment and the smooth, off-white suppositories are formulated for the relief of ... "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208". Retrieved 2009-01-21. "Sanofi Aventis: Hoechst ...
... was also available as a rectal suppository, but such formulations were banned by the U.S. Food and Drug ... Waknine, Yael (April 6, 2007). "FDA Bans Suppositories With Trimethobenzamide". Medscape. Retrieved 2007-04-06.[dead link] ...
The drug is available in the form of drops, suspensions and suppositories. The drug is used for the treatment of dry cough ... The plasma half life is 2.3 hours for oral formulations and three to 3.5 hours for suppositories. Pentoxyverine is also ... It melts at 90 to 95 °C (194 to 203 °F). Other orally available salts are the hydrochloride and the tannate; suppositories ... The bioavailability of the suppositories, measured as area under the curve (AUC), is about twofold that of oral formulations, ...
ISBN 978-0-300-10002-0. Suppository Writing. Southampton, MA: Chuckwagon, 2008. 24 pp. Unpaginated. Contributor Notes. Interval ...
A rudimentary form of "dry" enema is the use of a non-medicated glycerin suppository. However, due to the relative hardiness of ... "Glycerin Suppository". American Cancer Society. American Cancer Society, Inc. Retrieved 9 May 2012. (Articles needing ... the suppository - necessary for its insertion into the human body - before glycerin can act, it must be melted by the heat of ... the hygroscopic glycerin irritates the sensitive membranes of the rectum resulting in forceful expulsion of the suppository ...
Rectal administration usually involves rectal suppositories.) The mechanism for drug absorption from the intestine is for most ...
... suppositories), rectal (suppositories), by intramuscular or subcutaneous injection (in oil solutions or aqueous suspensions), ... Testosterone was marketed as a suppository for rectal administration by Ferring Pharmaceuticals from the early 1960s under ... Testosterone can be used by vaginal administration of creams, suppositories, and vaginal rings available from compounding ... Hamburger C (February 1974). "Testosteronesuppositorier DA" [Letter: Testosterone suppositories DAK]. Ugeskr Laeger (in Danish ...
"Administration of Rectal Suppositories or Enemas". Latest FDA Medication Alert. Institute for Safe Medication Practices. ...
"Definition of SUPPOSITORY". www.merriam-webster.com. Retrieved 2020-07-04. Hua S (2019-10-16). "Physiological and ... Constipation that persists may require enemas or suppositories. Sometimes, use of the fingers or hand (manual evacuation) is ... Some medications are also administered via the rectum (Latin: per rectum). By their definitions, suppositories are inserted, ...
In the past, dihydrocodeine suppositories were used. Dihydrocodeine is available in suppository form on prescription. ...
... or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and ...
Hemorrhoidal suppository Daily Med. Retrieved 28 March 2013. Oguri, M (1990) "A review of selected physiological ...
It is sold as suppositories, tablets, and syrup. It is used to stop a cough caused by allergies or a cold. Adverse effects ...
... suppositories are also marketed in some countries. Common adverse effects associated with the use of codeine include ...
The Anusol range includes creams, ointments, and suppositories. Anusol is now known under the brand name Tucks in the United ... The active ingredient in Anusol ointment and suppositories is zinc sulfate monohydrate which helps decrease the irritation in ...
Amphotericin B vaginal suppositories are used as an effective form of treatment in combination with boric acid capsules as they ... Amphotericin B vaginal suppositories have also been used in case studies to treat chronic infections, both symptomatic and ... Compounding pharmacies can create boric acid vaginal suppositories. Use of Vitamin E oil may be used in conjunction to combat ...
"Terconazole Vaginal Cream, Vaginal Suppositories: MedlinePlus Drug Information". medlineplus.gov. Retrieved 2020-08-05. " ... when used as a vaginal cream or vaginal suppository, as well as butoconazole vaginal cream. According to the American Society ... using tampons while being treated with any of several medications taken by the vaginal route such as vaginal suppositories and ...
Suppositories can, in some situations, be administered instead. Medication can also be administered through intramuscular ...
Estradiol itself was also marketed in the 1930s and 1940s in the form of oral tablets and solutions, vaginal suppositories, and ... Marketed vaginal estradiol suppositories were also used rectally. Estradiol dipropionate, another short-acting ester of ... suppositories, and nasal spray. [...] PROGYNON-DH Nasal Spray has been prepared especially for use in [the treatment of ... suppositories), rectal, by intramuscular or subcutaneous injection (in oil or aqueous), and as a subcutaneous implant. The ...
Alprostadil is sold in the United States as urethral suppositories and in injectable form. The suppositories are sold under the ... "Muse Suppository - Facts and Comparisons". Drugs.com. Archived from the original on 19 January 2013. Retrieved 4 January 2013 ... Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is ...
It may also be used rectally in suppositories to relieve the swelling, itch, and irritation in haemorrhoids. It may be used as ... "Anusol HC- hydrocortisone acetate suppository". DailyMed. Retrieved 21 February 2021. "Cortef- hydrocortisone tablet". DailyMed ...
"Anusol HC- hydrocortisone acetate suppository". DailyMed. U.S. National Library of Medicine. Retrieved 13 April 2023. "Patterns ...
... suppositories, and vaporization. Amidst an early 20th century trend of limiting the drug, Iowa prohibited cannabis in 1923. ...
It is available as tablets, suppositories, and injection fluid. A sustained release formulation exists, sold as Ketodur, in ...
Local treatment may include vaginal suppositories or medicated douches. Other types of yeast infections require different ...
As a suppository, acetarsol was researched to be used for the treatment of proctitis. Although the mechanism of action is not ... It has been given in the form of suppositories. Acetarsol can be used to make arsthinol.[citation needed] It has been cancelled ...
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  • The drug artesunate, given in rectal suppository form, provides a potential solution to this problem: it can be made available in remote areas and thus can be given at the onset of symptoms. (wikipedia.org)
  • Significant work with artemisinin suppositories in severe malaria was conducted in Viet Nam in the early 1990s, and clinical trials of rectal artesunate followed by mefloquine treatment in moderately severe malaria were conducted in the mid-1990s in Thailand. (wikipedia.org)
  • A major placebo-controlled clinical trial published in 2009 found that "if patients with severe malaria cannot be treated orally and access to injections will take several hours, a single inexpensive artesunate rectal suppository at the time of referral substantially reduces the risk of death or permanent disability. (wikipedia.org)
  • Key-E Suppositories for vaginal or rectal use. (carlsonlabs.com)
  • Anusol suppositories are placed in the rectum and have active ingredients that soothe and treat rectal discomfort and itching. (welzo.com)
  • Artemisinin-based suppositories : use of rectal artemisinin-based suppositories in the management of severe malaria : report of a WHO informal consultation, 27-28 March 2006. (who.int)
  • Use of rectal artemisinin-based suppositories in the management of severe malaria. (who.int)
  • Among women with genitourinary syndrome of menopause, 12 weeks of treatment with vaginal suppositories containing hyaluronic acid (HLA) reduces vulvovaginal symptoms, according to trial results presented at the 2023 Menopause Meeting. (medscape.com)
  • The study was funded by Bonafide Health, a company that sells supplements to treat menopause symptoms, including vaginal suppositories containing HLA. (medscape.com)
  • Terconazole comes as a cream and suppository to insert into the vagina. (medlineplus.gov)
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  • These suppositories are given rectally due to the risk of death from severe malaria, as described below. (wikipedia.org)
  • The Magic Bullet Suppository - HCPCS N/A Magic Bullet® Suppositories are water soluble and allow the active ingredient (bisacodyl) to disperse within minutes of insertion. (livingspinal.com)
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  • Hyaluronic Acid Suppository Improves Menopause Symptoms - Medscape - Sep 29, 2023. (medscape.com)
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  • This is why our Shaykh Ibn 'Uthaymeen (may Allah have mercy on him) said- after presenting the view that suppositories and enemas do not break the fast- "Based on this opinion I say, "Enemas do not nullify the fast at all, even if the body get nutrition from them through the small intestines. (almosleh.com)
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