A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.
Decarboxylated monoamine derivatives of TRYPTOPHAN.
A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.
Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.
A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.
Drugs used to cause constriction of the blood vessels.
A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
A vessel that directly interconnects an artery and a vein, and that acts as a shunt to bypass the capillary bed. Not to be confused with surgical anastomosis, nor with arteriovenous fistula.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Arteries which supply the dura mater.
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
A group of compounds that contain the structure SO2NH2.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.
Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.
Recurrent unilateral pulsatile headaches, not preceded or accompanied by an aura, in attacks lasting 4-72 hours. It is characterized by PAIN of moderate to severe intensity; aggravated by physical activity; and associated with NAUSEA and / or PHOTOPHOBIA and PHONOPHOBIA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
A partnership, corporation, association, or other legal entity that enters into an arrangement for the provision of services with persons who are licensed to practice medicine, osteopathy, and dentistry, and with other care personnel. Under an IPA arrangement, licensed professional persons provide services through the entity in accordance with a mutually accepted compensation arrangement, while retaining their private practices. Services under the IPA are marketed through a prepaid health plan. (From Facts on File Dictionary of Health Care Management, 1988)
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Services providing pharmaceutic and therapeutic drug information and consultation.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
The giving of drugs, chemicals, or other substances by mouth.

[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum. (1/208)

1. The primary aim of this investigation was to determine whether binding sites corresponding to the 5-HT7 receptor could be detected in smooth muscle of the rat jejunum. Binding studies in rat brain (whole brain minus cerebellum) and guinea-pig ileal longitudinal muscle were also undertaken in order to compare the binding characteristics of these tissues. Studies were performed using [3H]-mesulergine, as it has a high affinity for 5-HT7 receptors. 2. In the rat brain and guinea-pig ileum, pKD values for [3H]-mesulergine of 8.0 +/- 0.04 and 7.9 +/- 0.11 (n = 3) and Bmax values of 9.9 +/- 0.3 and 21.5 +/- 4.9 fmol mg(-1) protein were obtained respectively, but no binding was detected in the rat jejunum. [3H]-mesulergine binding in the rat brain and guinea-pig ileum was displaced with the agonists 5-carboxamidotryptamine (5-CT) > 5-hydroxytryptamine (5-HT) > or = 5-methoxytryptamine (5-MeOT) > sumatriptan and the antagonists risperidone > or = LSD > or = metergoline > ritanserin > > pindolol. 3. Despite the lack of [3H]-mesulergine binding in the rat jejunum, functional studies undertaken revealed a biphasic contractile response to 5-HT which was partly blocked by ondansetron (1 microM). The residual response was present in over 50% of tissues studied and was found to be inhibited by risperidone > LSD > metergoline > mesulergine = ritanserin > pindolol, but was unaffected by RS 102221 (3 microM), cinanserin (30 nM), yohimbine (0.1 microM) and GR 113808 (1 microM). In addition, the agonist order of potency was 5-CT > 5-HT > 5-MeOT > sumatriptan. 4. In conclusion, binding studies performed with [3H]-mesulergine were able to detect 5-HT7 sites in rat brain and guinea-pig ileum, but not in rat jejunum, where a functional 5-HT7-like receptor was present.  (+info)

Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. (2/208)

AIMS: Sumatriptan is a 5-HT1B/1D-receptor agonist which also has affinity for 5-HT1F-receptors. The vasoconstrictor effects of sumatriptan are thought to be 5-HT1B-receptor mediated and these receptors have been shown to be expressed in human cranial blood vessels. However, in the same tissue mRNA coding for 5-HT1F-receptors has also been identified and this study addresses the possibility of whether 5-HT1F-receptor activation contributes to vasoconstriction. METHODS: The ability of two selective 5-HT1B/1D-receptor antagonists (GR125,743 and GR127,935) with no affinity for 5-HT1F-receptors, to inhibit sumatriptan evoked contractions in human isolated middle meningeal artery was investigated. Using a series of 5-HT1B/1D-receptor agonists (sumatriptan, zolmitriptan, CP122,288, L-741,519 and L-741,604), some with high affinity for 5-HTIF-receptors and the non-selective 5-HT-receptor agonists 5-HT and 5-CT, we compared the vasoconstrictor potency of these drugs in human isolated middle meningeal artery with their affinities at cloned human 5-HT1B-, 5-HT1D-and 5-HT1F-receptors expressed in CHO cell lines. RESULTS: GR125,743 antagonized sumatriptan evoked contractions in a competitive manner (apparent pA2 9.1) and GR127,935 antagonized sumatriptan-induced responses in a non-competitive manner (reducing the maximum contraction to 27%). There was a significant correlation between vasoconstrictor potency and 5-HT1B-receptor affinity (r=0.93, P=0.002) but not with 5-HT1D- or 5-HT1F-receptor affinity (r=0.74, P=0.06; r= 0.31, P= 0.49, respectively). CONCLUSIONS: These experiments show that in human middle meningeal artery vasoconstriction to sumatriptan-like agents is 5-HT1B-receptor mediated with little if any contribution from 5-HT1F-receptor activation.  (+info)

Cost-effectiveness of sumatriptan in a managed care population. (3/208)

We conducted an open-labeled study to determine whether sumatriptan is more cost-effective than other therapies used to treat migraine headache. We contacted by phone 220 sumatriptan users enrolled in QualMed, a health maintenance organization (HMO) in Spokane, Washington. Of these, 203 met the inclusion criteria and 164 (81%) completed our telephone survey. The main outcome measures were healthcare costs to the HMO and number of days free of migraine-related disability before and after sumatriptan treatment. Before sumatriptan treatment, 89% of patients reported severe migraine, compared with 63% after sumatriptan treatment. The number of monthly migraine disability days decreased from 6.5 days per month before sumatriptan to 3.9 days per month after sumatriptan. Healthcare utilization rates (ie, number of hospitalizations, emergency department visits) and costs were lower after the patients began taking sumatriptan. The number of different over-the-counter medicines and prescription medications (other than sumatriptan) taken for migraine disabilities decreased. Although total drug expenditures per month increased, the total migraine healthcare expenditure was 41% lower after sumatriptan was initiated. The cost-effectiveness ratio was 47% more favorable after patients started taking sumatriptan. Overall, patients reported fewer migraine-related disabilities, had lower migraine severity scores, and used fewer healthcare resources when taking sumatriptan. These changes resulted in a better cost-effectiveness ratio for migraine treatment.  (+info)

Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors. (4/208)

The antimigraine drugs methysergide, ergotamine and dihydroergotamine (DHE) produce selective vasoconstriction in the external carotid bed of vagosympathectomized dogs anaesthetized with pentobarbital and artificially respired, but the receptors involved have not yet been completely characterized. Since the above drugs display affinity for several binding sites, including alpha-adrenoceptors and several 5-HT1 and 5-HT2 receptor subtypes, this study has analysed the mechanisms involved in the above responses. Intracarotid (i.c.) infusions during 1 min of methysergide (31-310 microg min(-1)), ergotamine (0.56-5.6 microg min(-1)) or DHE (5.6-31 microg min(-1)) dose-dependently reduced external carotid blood flow (ECBF) by up to 46+/-4, 37+/-4 and 49+/-5%, respectively. Blood pressure and heart rate remained unchanged. The reductions in ECBF by methysergide were abolished and even reversed to increases in animals pre-treated with GR127935 (10 microg kg(-1), i.v.). The reductions in ECBF by ergotamine and DHE remained unchanged in animals pre-treated (i.v.) with prazosin (300 microg kg(-1)), but were partly antagonized in animals pre-treated with either GR127935 (10 or 30 microg kg(-1)) or yohimbine (1000 microg kg(-1)). Pre-treatment with a combination of GR127935 (30 microg kg(-1)) and yohimbine (1000 microg kg(-1)) abolished the responses to both ergotamine and DHE. The above doses of antagonists were shown to produce selective antagonism at their respective receptors. These results suggest that the external carotid vasoconstrictor responses to methysergide primarily involve 5-HT1B/1D receptors, whereas those to ergotamine and DHE are mediated by 5-HT1B/1D receptors as well as alpha2-adrenoceptors.  (+info)

The inhibition of nicotine-evoked relaxation of the guinea-pig isolated basilar artery by some analgesic drugs and progesterone. (5/208)

1. The purpose of this study was to investigate the mechanism of nicotine-evoked relaxation of the guinea-pig isolated basilar artery and to study the effects of drugs associated with the aetiology or treatment of migraine on the nicotine response. 2. The guinea-pig isolated basilar artery, pre-contracted with prostaglandin F2alpha (PGF2alpha), in the presence of atropine (3 microM) and guanethidine (3 microM), relaxed on addition of nicotine (0.1 mM) in approximately 50% of preparations. The responses to nicotine were of short duration and blocked in preparations pre-treated for 10 min with capsaicin (1 microM) and are therefore probably a consequence of the stimulation of trigeminal C fibre terminals. 3. Responses to nicotine were reduced in the presence of 5-carboxamidotryptamine, 5-hydroxytryptamine and sumatriptan in that order of potency. This is consistent with a 5-HT1 receptor mechanism. These agonists evoked small additional contractions in vessels pre-contracted with PGF2alpha. 4. Indomethacin (0.3-10 microM), aspirin (10-30 microM), and nitro-L-arginine methyl ester (L-NAME, 0.1 mM) reduced nicotine-evoked relaxation of the basilar artery, suggesting the involvement of both nitric oxide and cyclo-oxygenase products in this response. 5. Progesterone (1 microM) markedly reduced the response to nicotine, a possible reflection of the ion channel blocking activity of high concentrations of this compound. 6. The guinea-pig basilar artery is a preparation in which the effects of drugs on responses to stimulation of trigeminal nerve terminals can be studied in vitro and may thus be of interest in assessing the actions of drugs used in treatment of headache.  (+info)

Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug. (6/208)

We have investigated the regulation of calcitonin gene-related peptide (CGRP) release from trigeminal neurons by the serotonergic antimigraine drug sumatriptan. Serum levels of the neuropeptide CGRP are elevated during migraine. Treatment with the drug sumatriptan returns CGRP levels to normal coincident with the alleviation of headache. However, despite this clinical efficacy, the cellular target and mechanism of sumatriptan action are not well understood beyond the pharmacology of its recognition of the 5-HT1 class of serotonin receptors. We have used cultured trigeminal neurons to demonstrate that sumatriptan can directly repress CGRP secretion from sensory neurons. The stimulated secretion in response to depolarization or inflammatory agents was inhibited, but not the basal secretion rate. Unexpectedly, sumatriptan did not lower cAMP levels, in contrast to the classical role ascribed to the 5-HT1 receptors. Instead, activation of 5-HT1 receptors caused a slow and remarkably prolonged increase in intracellular calcium. The inhibition of CGRP secretion is attenuated by the phosphatase inhibitor okadaic acid, suggesting that sumatriptan action is mediated by calcium-recruited phosphatases. These results suggest that 5-HT1 agonists may block a deleterious feedback loop in migraine at the trigeminal neurons and provide a general mechanism by which this class of drugs can attenuate stimulated neuropeptide release.  (+info)

Altered oesophageal motility following the administration of the 5-HT1 agonist, sumatriptan. (7/208)

BACKGROUND: The 5-HT1 agonist sumatriptan, used in the treatment of migraine, can cause chest pain. AIM: To investigate the effect of a therapeutic dose of sumatriptan (6 mg s.c.) on oesophageal motility. METHODS: In 16 normal healthy subjects aged 19-32 years (9 males), the manometric response of the lower oesophageal sphincter (sleeve sensor), oesophageal body (four sites), stomach and pharynx (to register swallows) to 5 mL water swallows was assessed before and after a subcutaneous injection of either sumatriptan (6 mg) or saline control. Symptoms and ECGs were also monitored. RESULTS: Sumatriptan 6 mg s.c. altered oesophageal motility in all subjects. This was reflected by a significant increase in the amplitude of oesophageal body contractions (change from pre- to 1 h post-injection: sumatriptan 9.9 (2.8, 17.1) mmHg vs. placebo -0.8 (-4.2, 2.6) mmHg, difference 10.8 (4.4, 17.1) mmHg; P=0.003) and a transient increase in lower oesophageal sphincter pressure (change from pre- to 5 min post-injection: sumatriptan 10.9 (5.2, 16.6) mmHg vs. placebo 5.1 (1.8, 8.4) mmHg, difference 5.8 (-0.7, 12.3) mmHg; P=0.08). Sumatriptan had no effect on the velocity of propagation of oesophageal contractions (change from pre- to 1 h post-injection: sumatriptan -0.1 (-0.3, 0.1) cm/s vs. placebo -0.1 (-0.3, 0.0) cm/s, difference 0.1 (-0.1, 0.2) cm/s; P = 0.40). One subject experienced chest symptoms following sumatriptan and, although motility was altered, this did not reach pathological levels. No ECG abnormalities were observed. CONCLUSION: Sumatriptan (6 mg s.c.) significantly alters oesophageal motor function without affecting the ECG. It is therefore possible that sumatriptan-induced chest symptoms may have an oesophageal origin. The evaluation of similar therapeutic agents for migraine on oesophageal function may be justified.  (+info)

Investigation of the role of 5-HT1B and 5-HT1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses. (8/208)

1. It has previously been shown that the antimigraine drug sumatriptan constricts porcine carotid arteriovenous anastomoses via 5-HT1-like receptors, identical to 5-H1B/1D receptors. The recent availability of silent antagonists selective for the 5-HT1B (SB224289) and 5-HT1D (BRL15572) receptor led us to further analyse the nature of receptors involved. 2. In pentobarbitone-anaesthetized, bilaterally vagosympathectomized pigs, sumatriptan (30, 100 and 300 microg kg(-1), i.v.) dose-dependently decreased carotid arteriovenous anastomotic conductance by up to 70+/-5%. 3. The dose-related decreases in carotid arteriovenous anastomotic conductance by sumatriptan (30, 100 and 300 microg kg(-1), i.v.) remained unchanged in animals treated (i.v.) with 1 mg kg(-1) of BRL15572 (maximum decrease: 72+/-3%), but were significantly attenuated by 1 mg kg(-1) (maximum decrease: 30+/-11%) and abolished by 3 mg kg(-1) (maximum decrease: 3+/-7%) of SB224289. The highest dose of SB224289 did not attenuate the hypertension, tachycardia or increases in carotid blood flow induced by bolus injections of noradrenaline (0.1-3 microg kg(-1), i.v.). 4. The results indicate that sumatriptan constricts porcine carotid arteriovenous anastomoses primarily via 5-HT1B, but not via 5-HT1D receptors.  (+info)

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Zogenix has announced successful results from two clinical studies of sumatriptan DosePro, a product in development for treatment of acute migraine and cluster headache. The first clinical study evaluated the pharmacokinetics, bioequivalence and safety of needle-free sumatriptan DosePro, compared to a needle-based autoinjector, Imitrex STATdose used in the treatment of migraine. DosePro is a novel, patented, needle-free technology that delivers the drug directly through the skin into the subcutaneous space without a needle. In the study involving healthy adult subjects, sumatriptan DosePro was bioequivalent to the needle-based autoinjector in the abdomen and thigh injection sites, and showed that maximum plasma concentrations of sumatriptan were reached rapidly, within approximately 12 minutes. Sumatriptan DosePro and Imitrex STATdose treatments also exhibited highly similar safety profiles. The second study, in which patients at home used sumatriptan DosePro as their primary means of treating ...
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Sumatriptan Succinate is used for the treatment of migraine headaches, nausea, sensitivity to light and sound, and other migraine symptoms. At least 2% of patients headache pain in controlled by trials of Imitrex (25, 50, and 100 mg tablets) for migraine and sensations.
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Suminat Sumatriptan 100 mg is a group of medication that is used in treating migraines. It helps to get relief from a headache, pain, and other symptoms of migraines, You can buy sumatriptan 100mg online from premiumrxdrugs.com at affordable price
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Bottom line. The combination of sumatriptan plus naproxen was useful for treating migraine attacks in the studies we found. It was not a lot better than using sumatriptan alone, but it was much better than using naproxen alone. Attacks were more successfully treated when medication was taken early, when pain was mild.. Background. Migraine is a complex condition with a wide variety of symptoms. It affects two to three times more women than men, and is most common in the age range 30 to 50 years. For many people, the main feature is a painful headache. Other symptoms include disturbed vision; sensitivity to light, sound, and smells; feeling sick; and vomiting.. Both nonsteroidal anti-inflammatory drugs (NSAIDs) and the triptan class of drugs are used to treat migraine headaches. This review examined how well naproxen (an NSAID) and sumatriptan (a triptan) work when combined. The combination tablet is not available in most countries, but separate tablets are widely available and can be taken ...
While Zembrace (sumatriptan) can be used to treat migraines, its only available as a brand name so it can be expensive. Zembrace (sumatriptan) is only available as a brand name and it can be expensive. There are generic versions of this medicine that you can inject that are stronger and cheaper than Zembrace (sumatriptan).
This study will evaluate the exposure of sumatriptan after administration of TREXIMA (sumatriptan 85mg/naproxen sodium 500mg) followed by a subcutaneous
Sumatriptan, Sumatriptan is a migraine treatment that is most effective during the onset of a migraine. You must be diagnosed with Migraines before purchasing from our Doctors.
Risk Summary Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected an increased frequency of birth defects or a consistent pattern of birth defects among women exposed to sumatriptan compared with the general population (see Data). In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal (see Data). In the U.S. general population, the estimated background risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. The reported rate of major birth defects among deliveries to women with migraine ranged from 2.2% to 2.9% and the reported rate of miscarriage was 17%, which were similar to rates reported in women without migraine.. Clinical Considerations ...
Suminat Nasal Spray (Sumatriptan) is used for the treatment of migraine attacks in adults. It also relieves the nausea and other symptoms, such as sensitivity to light, that often accompany migraines.
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There remains a great need for more effective anti-migraine drugs with fewer side effects. Human experimental models are valuable in early phase development of new anti-migraine drugs but useful models have not yet been developed. The investigators group has shown that Cilostazol, a phosphodiesterase inhibitor induce headache/migraine in both healthy volunteers and in patients with migraine without aura (MO). To validate this model, the headache must respond to specific migraine treatment with sumatriptan.. Hypothesis: Cilostazol induces a migraine-like headache in MO-patients and the induced headache responds to sumatriptan injection Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs. ...
Top Left: Box from pharmacy. Top Right: Carrying case. Second Item from the Bottom: Auto-injector loaded and ready to use. Bottom: Glass vial that contains the drug (Sumatriptan Succinate) removed from inside the cartridge. Not Shown in Picture but included: Instructions for Use / Information for the Patient and Prescribing Information. -----------------------------------------. Generic Name: Sumatriptan Succinate ...
BACKGROUND: Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebr
Product name: Imitrex (Sumatriptan) . Known As: Imitrex . Were to buy (Follow this link): http://bit.ly/17PgORj . Price (Per pill): from $ 3.00 to $ 4.99, Per pill . Used to: Generic Imitrex is used for the treatment of migraine headaches with or without aura (eg, flashing lights, wavy lines, dark spots). . Payment method: Visa / MasterCard / Western Union / MoneyGram . . . Rating: 98% based on 1068 user votes. . . . . . . . . . . . . . . . . . ,h3,Buy Imitrex Online Pharmacy Next Day Delivery,/h3,,br,,p,Compare prices and print coupons for Sumatriptan (Imitrex) and other White Oblong Rdy And 293 - Sumatriptan Succinate 100mg Tablet Buy Online. At-a-glance. Triptans are effective medicines used to treat migraine headaches. Buy Drug: - Sumatriptan (generic) tablets, nasal spray, and inj eIKRxNImitrex 25mg * Imitrex 25mg Migraine Canadian Drugs ...
The release of a generic substitute of the branded drug Imitrex (sumatriptan) has dramatically reduced the cost and improved the access to this uniquely effective migraine drug. The generic sumatriptan was released four years ago and now the price of one tablet is down to about $3 from over $20. The cost of two other…
Overcome migraines and order Sumatriptan online. Sumatriptan offers fast-relief when over-the-counter painkillers just arent enough. Prices from £9.99
Intranasal sumatriptan powder seems to be a new and very promising way to deliver a migraine drug. Sumatriptan (Imitrex) nasal spray has been available for many years, however it is not very effective or at least is not consistently effective. The liquid tends to leak out of the nose, get swallowed, or just not get…
Migraines have the ability to bring everything to a stop. Luckily, Sumatriptan is here to help. Lets take a deeper look at what Sumatriptan is and how it can help.
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Sumatriptan Medicament Générique Imitrex Ou Achetez Le Moins Cher Imitrex. Imitrex générique (Sumatriptan) est un vasoconstricteur cérébral utilisé pour…
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Martha, My pierre has myocardial very well with nortiptyline: she gained a little weight at the beginning, but has lost it. IMITREX was follicular but I thought of too. These metabolites are excreted in the literature. I know I have a headache or had one of the dominance. Just cuz its codeine, ya get away with a pressure pack on the same migraine as IMITREX gets broken down in the various stages of testing, but expectations are high. I IMITREX is cluster headaches but my IMITREX is that IMITREX takes 2 - 3 weeks - sorry if I have fewer migraines since midnight and just can not only be the one co- pay price. There are currently too many topics in this same area different migraines take involves more than 800 popping in a hot car in summer, in rush IMITREX has to come by and i go to Mexico to get a poke of Demerol and Phenergen at the height of my symptoms since its nearly disputed as curtain coming down vertically.. ...
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Allergy: If you are allergic to sulphonamides (sulfa medications) you may experience an allergic reaction to sumatriptan. Reactions range from a skin allergy to a serious allergic reaction. If you are allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) you can also have an allergic reaction to sumatriptan. If you are allergic to any of these medications, you should not take sumatriptan unless advised to do so by your doctor.. Blood pressure: Sumatriptan may cause an increase in blood pressure. If you have severe or uncontrolled high blood pressure, do not take sumatriptan.. Drowsiness/reduced alertness: Drowsiness may occur as a ...
Ava-Sumatriptan is a specialty drug on the Reformulary and can be used to treat Migraines. Check with your doctor if there are other medications you can take before taking this drug.
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We studied the effect of the selective serotonin re-uptake inhibitor (SSRI), paroxetine (20 mg daily for 16 days) on the neuroendocrine, cardiovascular, thermic and subjective responses to the 5-HT1D receptor agonist, sumatriptan (6 mg, SC). Compared to placebo injection, sumatriptan lowered plasma prolactin and oral temperature and increased diastolic blood pressure. While paroxetine increased baseline prolactin concentration, it had no effect on any of the responses to sumatriptan. In addition, paroxetine did not alter concentrations of sumatriptan in plasma. No adverse reactions resulted from the combination of sumatriptan and paroxetine. Our findings suggest that combined treatment with sumatriptan and paroxetine in the doses used in this study is not necessarily contra-indicated. In addition, short-term SSRI treatment may not desensitise 5-HT1D autoreceptors in humans.
Looking for online definition of Sandoz Sumatriptan in the Medical Dictionary? Sandoz Sumatriptan explanation free. What is Sandoz Sumatriptan? Meaning of Sandoz Sumatriptan medical term. What does Sandoz Sumatriptan mean?
Professional guide for Sumatriptan/Naproxen Sodium. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Prior to 2000, various trials established the effectiveness of sumatriptan in the treatment of acute migraine attacks. One crossover, double-blind, randomized, multicenter trial evaluated the efficacy and safety of oral sumatriptan 50 mg compared with placebo in 233 patients over the course of 12 migraine attacks. The crossover design resulted in a carry-over effect because the placebo was present only once for each randomized block of four attacks, meaning that each patient received nine active treatments and three placebo treatments for his or her 12 migraine attacks. Patients, who were aged 18 to 65 years, met International Headache Society criteria for migraine and had experienced migraine attacks of moderate-to-severe intensity for at least 1 year, with a frequency of one to six attacks per month. In the study, oral sumatriptan effectively relieved associated symptoms such as such as nausea, vomiting, photophobia, and phonophobia and reduced clinical disability caused by migraines. The ...
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Compound sumatriptan offers an effective treatment for pediatric and adolescent migraines. Sumatriptan was recently approved by the FDA.
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Learn about the potential side effects of naproxen/sumatriptan. Includes common and rare side effects information for consumers and healthcare professionals.
Efficacy and safety of intravenous acetylsalicylic acid lysinate compared to subcutaneous sumatriptan and parenteral placebo in the acute treatment of migraine. A double-blind, double-dummy, randomized, multicenter, parallel group study. The ASASUMAMIG Study Group. Diener HC. Cephalalgia. 1999 Jul; 19(6):581-8; discussion 542. ...
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Taro-Sumatriptan: Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Sumatriptan relieves migraine headaches by constricting these blood vessels.
US WorldMeds, LLC, announced today that it has launched the recently Food and Drug Administration-approved ALSUMA Auto-Injector, which is indicated for the acute treatment of migraine attacks with or without aura, and cluster headache episodes
Drug Information. Imitrex belongs to a drug group named as triptans. These drugs directly affect the function of serotonin in the body.. It is used to treat migraines as it facilitates blood flow to the brain by limiting the narrowing of blood vessels due to serotonin.. However, Imitrex is not a permanent solution for migraines and will not be able to reduce the frequency at which you experience migraine related symptoms such as nausea and dizziness in the future.. Dosage. This drug should be taken orally with our without food. The dosage and frequency of taking the drug will be decided by your doctor according to your health condition. If the symptoms of migraine fail to diminish after taking the recommended dosage, you may be able to take a second dosage after about 2 hours of the first one. However, it is best to consult with your doctor prior to doing so.. If the migraines do not reduce even after using the drug for a few days, you should stop taking the drug any further and consult with the ...
Mine always start on one side of my head toward the front, usually in the temple, and then spread to the other side. Sometimes itll last as both sides for a long time, sometimes it will fade from the starting side. Occasionally it seems like its my entire head, my neck gets sore. Over the first year, they got progressively worse and more frequent. Prescribed sumatriptan tablets to take in response, eventually had one that didnt respond to it and went to the ER about it. Got butabitol-caffeine-acetaminophen-codeine caps for what I call the super migraines and the overall frequency (normal and super) got to once a week, some migraines would also linger on for 3 days. GP put me on increasing doses of propranolol with only minor improvement, but I was feeling sluggish and vague. I went to see a neurologist, he switched me to topamax and got me sumatriptan injections, also recommended a better magnesium supplement as well. The topamax has reduced my frequency and some of the intensity. Im not ...
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Trexima, a combination of sumatriptan (Imitrex) and naproxen sodium (found in Aleve and other NSAIDs), was expected to receive FDA approval last week. Requesting more safety data, the FDA has delayed approval of Trexima.. The concern is about one of the four tests of genotoxicity, which is toxicity to DNA. The requested data are available from a study that has already been conducted. The FDA will meet with Pozen and GSK soon to discuss additional requirements.. Related posts:. ...
ACT-Sumatriptan: Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine).
Generic Imigran (Sumatriptan) is a cerebral vasoconstrictor used to relieve migraine headache attacks as they occur. This medicine belongs to a group of medicines also known as
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Main / Travel Sickness / Abilify to geodon Abilify vs Geodon Comparison. Side-by-side comparison of medication uses, ratings, prices, side effects, interactions, warnings and more. A Moderate Drug Interaction exists between Abilify and Geodon. View detailed information regarding this drug interaction.. Geodon vs abilify: Im 34 teaspoon old abilify to geodon, currently on 80mg abilify to geodon and 10 mg abilify. Abilify has made me have 20 lbs. He now is drying me to jumpfly.infoing from abilify to geodon. She has had discolored weight gain over the over month and had been used in class yet legalized about not sleeping at relieving and he confirmed to switch her to Geodon from Abilify. I patched about tapering the abilify and was obtained to give her more of her pregnancy for three days. I beat that to mean that I. Although Imitrex has a stimulant form, sold under the name sumatriptan and naproxen sodium is the generic name for the trick name prescription drug Naprosyn and the over-the-counter ...
Author: Allen Loyd V Jr, Year: 2006, Abstract: A formulation for preparing Naratriptan Hydrochloride 0.5-mg/mL Oral Liquid. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches. Dilantin (phenytoin) is very good at treating and preventing seizures, but it has many drug interactions and some serious side effects.
Based on ArQ™, Oval is developing a sumatriptan autoinjector, Sumalen Ovali, for the treatment of migraines and cluster headaches.
5-HT1 receptor agonists (eg, sumatriptan), linezolid, lithium, MAOIs (eg, phenelzine), quinidine, rasagiline, SNRIs (eg, venlafaxine), SSRIs (eg, fluoxetine, fluvoxamine), St. Johns wort, tramadol, or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may ...
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Zecuity, a sumatriptan transdermal patch, was approved by the US FDA in January 2013. The sumatriptan nasal powder was approved ... Sumatriptan and zolmitriptan are also available as nasal sprays. For sumatriptan, a number of other application forms are ... Comparison of sumatriptan and dihydroergotamine showed that dihydroergotamine has high affinity and sumatriptan has medium ... In studies, newer triptans are mostly compared to sumatriptan. They are better than sumatriptan for their longer half-life in ...
Arora A, Arora S (September 2006). "Spontaneous splenic infarction associated with sumatriptan use". J Headache Pain. 7 (4): ... sumatriptan or bevacizumab. In a single-center retrospective cases review, people who were admitted to the hospital with a ...
A third Migraleve variant, Migraleve Ultra, contains sumatriptan. The pink tablet is supposed to be taken before the yellow ... The active ingredient of Migraleve Ultra is 50 mg sumatriptan, similar to Imigran recovery. The Product Licence Holder is: ...
A schematic drawing of the binding of sumatriptan to 5-HT1D receptor can be seen in figure 4. One study showed that sumatriptan ... The sumatriptan nasal spray provides faster onset of action than the tablets but it produces a similar headache response at 2 ... Sumatriptan was first launched in the Netherlands in 1991 and became available in the United States during 1993. Triptans are ... The U.S. Food and Drug Administration (FDA) approved a new drug April 15, 2008, which is a combination of sumatriptan 85 mg and ...
SUMATRIPTAN 478. TACRINE HYDROCHLORIDE 479. TAMSULOSIN HYDROCHLORIDE 480. TRAPIDIL 481. TEGASEROD MALEATE ...
Therapeutic treatment for the prodromal phase, characterized by the anticipation of an episode, consists of sumatriptan (nasal ... "Adult Cyclic Vomiting Syndrome Successfully Treated with Intranasal Sumatriptan". Journal of General Internal Medicine. 25 (1 ...
Triptans such as sumatriptan are effective for both pain and nausea in up to 75% of people. When sumatriptan is taken with ... Law S, Derry S, Moore RA (April 2016). "Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults". The ... Aspirin can relieve moderate to severe migraine pain, with an effectiveness similar to sumatriptan. Ketorolac is available in ... Methysergide was developed in 1959 and the first triptan, sumatriptan, was developed in 1988. During the 20th century with ...
Sumatriptan and zolmitriptan have both been shown to improve symptoms during an attack with sumatriptan being superior. Because ... Valproate, sumatriptan, and oxygen are not recommended as preventive measures. Botulinum toxin injections have shown limited ... The other primarily recommended treatment of acute attacks is subcutaneous or intranasal sumatriptan. ...
This finding provided an incentive for the development of sumatriptan. Novartis withdrew it from the U.S. market after taking ... methysergide and sumatriptan - basic science in relation to migraine treatment". Headache. 52 (4): 707-14. doi:10.1111/j.1526- ...
Subcutaneous sumatriptan autoinjectors are used to terminate cluster headache attacks. Military uses include: Autoinjectors are ...
Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, ... Bouchelet I, Cohen Z, Case B, Séguéla P, Hamel E (Aug 1996). "Differential expression of sumatriptan-sensitive 5- ...
Several antimigraine drugs, available by the trade names of Imitrex- sumatriptan; Zomig - Zolmitriptan; Migranal - ...
Ogunyemi, A; Adams, D (May 1998). "Migraine-like symptoms triggered by occipital lobe seizures: response to sumatriptan". The ...
This includes methotrexate for juvenile idiopathic arthritis and sumatriptan for treatment of migraines. Most injector pens are ... "Subcutaneous sumatriptan delivery devices: comparative ease of use and preference among migraineurs". Patient Preference and ...
Drugs involving succinate include metoprolol succinate, sumatriptan succinate, Doxylamine succinate or solifenacin succinate.[ ...
Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J (2005). "Anxiogenic effects of Sumatriptan in panic disorder: a ...
A 2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan. Rizatriptan and other triptans can cause ... Göbel H (2010). "Efficacy and tolerability of rizatriptan 10 mg compared with sumatriptan 100 mg: an evidence-based analysis". ... Like the other triptans sumatriptan and zolmitriptan, rizatriptan induces vasoconstriction-possibly by inhibiting the release ...
It is a derivative of the migraine medication sumatriptan, but while CP-122,288 is 40,000 times more potent than sumatriptan as ... Waeber C, Moskowitz MA (September 1995). "[3H]sumatriptan labels both 5-HT1D and 5-HT1F receptor binding sites in the guinea ... 5-MeO-MPMI CP-135807 Eletriptan Lee WS, Moskowitz MA (October 1993). "Conformationally restricted sumatriptan analogues, CP- ... a conformationally restricted analogue of sumatriptan". European Journal of Pharmacology. 276 (3): 271-6. doi:10.1016/0014-2999 ...
Fanciullacci M, Sicuteri R, Alessandri M, Geppetti P (March 1995). "Buspirone, but not sumatriptan, induces miosis in humans: ...
Russia - Classified as a Schedule I narcotic, including its derivatives (see sumatriptan and zolmitriptan). Serbia - DMT, along ...
Triptans such as sumatriptan, rizatriptan, and naratriptan are 5-HT1B receptor agonists that are used to abort migraine and ... Triptans such as eletriptan, naratriptan, and sumatriptan are agonists of the 5-HT1F receptor. Lasmiditan is a selective 5-HT1F ... In addition to being 5-HT1B agonists, triptans (i.e. sumatriptan, almotriptan, zolmitriptan, naratriptan, eletriptan, ...
Many synthetic tryptamines have also been made, including the migraine drug sumatriptan, and psychedelic drugs. The tryptamine ...
Cohen ML, Schenck K, Nelson D, Robertson DW (January 1992). "Sumatriptan and 5-benzyloxytryptamine: contractility of two 5-HT1D ... 5-Carboxamidotryptamine 5-Methoxytryptamine BW-723C86 Sumatriptan Lyon RA, Titeler M, Seggel MR, Glennon RA (January 1988). " ...
... was shown not to interact with ethinyl estradiol, norgestimate or the migraine drug sumatriptan. It is expected to ...
Abortive therapy for cluster headaches includes subcutaneous sumatriptan (injected under the skin) and triptan nasal sprays. ...
5HT1 receptor agonists, such as sumatriptan, increase intracellular calcium, which cause decreases in CGRP promoter activity. ...
In this case, sulfhemoglobinemia was possibly caused by the patient taking higher-than-prescribed doses of sumatriptan. ... overdosing of sumatriptan). Sulfhemoglobinemia is usually drug induced. Drugs associated with sulfhemoglobinemia include ...
... has similar efficacy as a standard dose of sumatriptan, another triptan drug, and fewer adverse effects. As with ...
When sumatriptan binds there is major conformational change in both ligand and receptor in the binding pocket. 5-(Nonyloxy) ... tryptamine Sumatriptan (vasoconstrictor in migraine) 5-Carboxamidotryptamine (5-CT) 5-(t-Butyl)-N-methyltryptamine CP-135,807 ...
Sumatriptan: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking sumatriptan,. *tell your doctor and pharmacist if you are allergic to sumatriptan, any other medications, or any ... Sumatriptan comes as a tablet to take by mouth. It is usually taken at the first sign of a migraine headache.If your symptoms ... Take sumatriptan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
Sumatriptan Nasal: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using sumatriptan nasal,. *tell your doctor and pharmacist if you are allergic to sumatriptan, any other medications, or ... If your symptoms improve after you use sumatriptan but come back, you may use a second dose of sumatriptan (Imitrex, Onzetra ... Sumatriptan nasal may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *sore or ...
... Base (or) 3-[2-(Dimethylamino) ethyl]-N-Methyl-1H-Indole-5-Methane Sulfonamide ...
When injected, sumatriptan is faster-acting (usually within 10 minutes), but the effect lasts for a shorter time. Sumatriptan ... Nasal spray sumatriptan is also generically available. In Russia versions of sumatriptan, which are not registered in the ... Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which presumably accounts for sumatriptans ... Injected sumatriptan is more effective than other formulations. Overdose of sumatriptan can cause sulfhemoglobinemia, a rare ...
Ask questions and get answers about Sumatriptan. Our support group helps people share their own experience. 38 questions, 46 ... Sumatriptan Patient Information at Drugs.com. *Sumatriptan Information for Consumers. *Sumatriptan Information for Healthcare ... Sumatriptan - How long is sumatriptan good for?. Updated 26 Feb 2017 • 1 answer ... Sumatriptan - Why do they limit to 9 doses per month? I have 100mg that I split to 50 and often take. Updated 28 Aug 2016 • 3 ...
Sumatriptan-naproxen works well for migraine. BMJ 2007; 334 doi: https://doi.org/10.1136/bmj.334.7597.769-a (Published 12 April ...
Using sumatriptan alone or in combination with other migraine medicines for 10 or more days per month may lead to worsening of ... Sumatriptan may cause a serious condition called serotonin syndrome when used with some medicines. This especially includes ... Check with your doctor if you have used sumatriptan and your migraine got worse or started occurring more often. ...
Information about this sumatriptan-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Sumatriptan is used to treat acute migraine headaches in adults. It is not used to prevent migraine headaches and is not used ... Using sumatriptan alone or in combination with other migraine medicines for 10 or more days per month may lead to worsening of ... Sumatriptan works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called ...
Detailed drug Information for sumatriptan. Includes common brand names, drug descriptions, warnings, side effects and dosing ... Detailed Sumatriptan dosage information. Precautions while using sumatriptan. It is very important that your doctor check your ... Proper use of sumatriptan. Do not use sumatriptan for a headache that is different from your usual migraines. Talk to your ... Uses for sumatriptan. Sumatriptan is used to treat acute migraine headaches in adults. It is not used to prevent migraine ...
... sumatriptan succinate injection), including warnings and precautions, directions, and the names of other drugs and products ...
Prescriber Checkup » SUMATRIPTAN SUCCINATE SUMATRIPTAN SUCCINATE. Sumatriptan is used to treat the symptoms of migraine ... Top prescribers for SUMATRIPTAN SUCCINATE. « First ‹ Prev 1 2 3 4 5 6 7 8 … Next › Last » ...
Sumatriptan is used to treat migraine headaches and cluster headaches in adults. Sumatriptan... ... Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and ... Sumatriptan is a headache medicine that narrows blood vessels around the brain. ... What is sumatriptan injection?. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan ...
... and showed that maximum plasma concentrations of sumatriptan were reached rapidly, within approximately 12 minutes. Sumatriptan ... The second study, in which patients at home used sumatriptan DosePro as their primary means of treating migraine headache, ... Stephen Farr, president and COO of Zogenix, said: "This unique combination of ease of use and rapid sumatriptan absorption ... In the study involving healthy adult subjects, sumatriptan DosePro was bioequivalent to the needle-based autoinjector in the ...
The medication is part of an intranasal delivery system that includes a low-dose (22mg) of sumatriptan powder, which is ... resubmitted its New Drug Application to the U.S. Food and Drug Administration (FDA) last month for its sumatriptan migraine ... Last month the U.S. Food and Drug Administration (FDA) approved Treximet (sumatriptan and naproxen sodium) for use in pediatric ... The U.S. Food and Drug Administration recently approved Onzetra Xsail (sumatriptan nasal powder) for the treatment of migraine ...
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Sumatriptan is indicated for the acute treatment of migraine, with or without aura, and the acute treatment of cluster headache ... Generic Name: sumatriptan. Drug Class: Serotonin 5-HT-Receptor Agonists; Antimigraine Agents. What Is Sumatriptan and How Does ... Sumatriptan. https://reference.medscape.com/drug/imitrex-sumavel-dosepro-sumatriptan-343034 References: DailyMed. Sumatriptan. ... Sumatriptan is indicated for the acute treatment of migraine, with or without aura, and the acute treatment of cluster headache ...
... about Terry White Chemists Sumatriptan (sumatriptan) intended for persons living in Australia. ... The name of your medicine is Terry White Chemists Sumatriptan. It contains the active ingredient sumatriptan (as sumatriptan ... Terry White Chemists Sumatriptan tablets is available in 50 mg strength. Sumatriptan tablets are available in 50 mg and 100 mg ... other triptans (similar to sumatriptan) such as naratriptan and zolmitriptan. Do not take sumatriptan for 24 hours before or ...
A tablet that combines sumatriptan and naproxen (Treximet) has been approved by the FDA for treatment of migraine with and ... The drug delivers 85 mg of sumatriptan -- already used for migraine (Imitrex) -- with 500 mg of naproxen, in a single tablet ... LONDON, April 17 -- A tablet that combines sumatriptan and naproxen (Treximet) has been approved by the FDA for treatment of ... Compared with monotherapy with sumatriptan or naproxen or placebo, the combination pill provided better pain relief at two and ...
... sumatriptan) Recovery Tablets online at Pharmacy2U - used for the relief of migraine pain. ...
Sumatriptan Succinate) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... sumatriptan succinate) Injection. DESCRIPTION. IMITREX Injection contains sumatriptan succinate, a selective 5-HT1B/1D receptor ... Sumatriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Sumatriptan presumably exerts its therapeutic effects ... Sumatriptan is excreted in human milk following subcutaneous administration. Infant exposure to sumatriptan can be minimized by ...
Now, to make aborting a Migraine fast and pain-free, the FDA has just approved the first needle-free sumatriptan injection. ... DosePro is a first-of-its-kind needle-free delivery system for subcutaneous sumatriptan, a treatment that provides migraine ... This year, Migraine treatment changed again when patents expired, and the first generic triptan became available -- sumatriptan ... the rapid efficacy of subcutaneous sumatriptan and a simple to use needle-free delivery system. ...
Find reviews for Naproxen-sumatriptan from other patients. Learn from their experiences about effectiveness, side effects and ... 1 patient evaluation for Naproxen-sumatriptan taken for the purpose of migraine headaches with a perceived effectiveness ...
Migraine is not big on the list of my health issues but when I do get one the Sumatriptan works within a half hour. I take half ... I take 50 mg Sumatriptan for migraines. Most of the time my migraines are not head pain at all but rather vertigo they is ... Im very reactive to most medication and typically take half the dosage but take the full 50 mg of Sumatriptan. When I take it ... I was getting awful vertigo and throbbing migraines, put sumatriptan on top of it and thought I was not going to survive it. ...
Do not take sumatriptan if any of the following conditions apply to you:You are allergic to any ingredient ... Sumatriptan treatment is not for everyone. Do not take sumatriptan if any of the following conditions apply to you:. *You are ... Do not take sumatriptan for longer than prescribed for, as this can worsen your headaches. Elderly people should not take ... Because the effects of sumatriptan have not been evaluated in children under 18 years of age, it is not recommended for use in ...
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Sumatriptan Succinate 100 mg Tablets Under Fasting Conditions. The safety and scientific validity of this study is the ... Sumatriptan Succinate 100 mg Tablets Under Fasting Conditions. Official Title ICMJE A Two-Way Crossover, Open-Label, Single- ... The objective of this study is to compare the rate and extent of absorption of sumatriptan from a test formulation of ... Known history of hypersensitivity to sumatriptan (e.g. Imitrex®, Imigran®) and/or related drugs such as almotriptan, ...
Sumatriptan also reduces substances in the body that can trigger certain migraine symptoms. Naproxen is a nonsteroidal anti- ... Sumatriptan is a headache medicine that narrows blood vessels around the brain. ... What is sumatriptan and naproxen?. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan ... Sumatriptan and naproxen is a combination medicine used to treat migraine headaches. Sumatriptan and naproxen will only treat a ...
Sumatriptan relieves migraine headaches by constricting these blood vessels. ... Sumatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to ... Sumatriptan relieves migraine headaches by constricting these blood vessels.. Sumatriptan is not recommended for other types of ... Kidney function: The effect of reduced kidney function on how sumatriptan acts in the body has not been evaluated. Sumatriptan ...
Sumatriptan. Sumatriptan - Imitrex 100 Chevron Logo. Submitted by allgood on June 10, 2010 - 11:32pm ... Generic Name: Sumatriptan Strength: 100 mg. Manufacturer: GlaxoSmithKline. Trade Name: Imitrex. Type: Migraine Treatment. Class ... Generic Name: Sumatriptan, Naproxen Sodium Strength: 85 mg, 500 mg. Manufacturer: GlaxoSmithKline. Trade Name: Treximet. Type: ... Sumatriptan; Naproxen Sodium - G5 YYG. Submitted by allgood on June 8, 2010 - 10:59am ...
  • You may use your first dose of sumatriptan nasal in a doctor's office or other medical facility where you can be monitored for serious reactions. (medlineplus.gov)
  • Call your doctor if your headaches do not get better or occur more frequently after using sumatriptan nasal. (medlineplus.gov)
  • Sumatriptan is administered in several forms: tablets, subcutaneous injection, and nasal spray. (wikipedia.org)
  • The U.S. Food and Drug Administration recently approved Onzetra Xsail (sumatriptan nasal powder) for the treatment of migraine, with or without aura, in adults. (headaches.org)
  • Several medications were recently deemed the most effective for treating acute migraine, including triptans, dihydroergotamine (DHE), nonsteroidal anti-inflammatory drugs (NSAIDS), butorphanol nasal spray, and the combination medication of sumatriptan/naproxen and acetaminophen/aspirin/caffein). (headaches.org)
  • What are the possible side effects of sumatriptan (Imitrex, Imitrex Nasal)? (rxlist.com)
  • GlaxoSmithKline says, in its datasheet for nasal-spray Imitrex: 'In rats treated with a single subcutaneous dose (0.5 mg/kg) or oral dose (2 mg/kg) of radiolabeled sumatriptan, the elimination half-life of radioactivity from the eye was 15 and 23 days, respectively, suggesting that sumatriptan and/or its metabolites bind to the melanin of the eye. (usaeyes.org)
  • Sumatriptan (Imitrex) nasal spray has been available for many years, however it is not very effective or at least is not consistently effective. (nyheadache.com)
  • Read this Patient Information before you start using sumatriptan nasal spray, USP and each time you get a refill. (lannett.com)
  • Sumatriptan nasal spray, USP is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. (lannett.com)
  • What is sumatriptan nasal spray, USP? (lannett.com)
  • Sumatriptan nasal spray, USP is a prescription medicine used to treat acute migraine headaches with or without aura in adults. (lannett.com)
  • Sumatriptan nasal spray, USP is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines. (lannett.com)
  • Sumatriptan nasal spray, USP is not used to prevent or decrease the number of migraine headaches you have. (lannett.com)
  • It is not known if sumatriptan nasal spray, USP is safe and effective to treat cluster headaches. (lannett.com)
  • It is not known if sumatriptan nasal spray, USP is safe and effective in children under 18 years of age. (lannett.com)
  • an allergy to sumatriptan or any of the ingredients in sumatriptan nasal spray, USP. (lannett.com)
  • See the end of this leaflet for a complete list of ingredients in sumatriptan nasal spray, USP. (lannett.com)
  • It is not known if sumatriptan nasal spray, USP can harm your unborn baby. (lannett.com)
  • Talk with your healthcare provider about the best way to feed your baby if you use sumatriptan nasal spray, USP. (lannett.com)
  • How should I use sumatriptan nasal spray, USP? (lannett.com)
  • Certain people should use their first dose of sumatriptan nasal spray, USP in their healthcare provider's office or in another medical setting. (lannett.com)
  • Sumatriptan is available in the form of tablets, injections or nasal sprays. (differencebetween.net)
  • MAPLE GROVE, Minn. - Upsher-Smith recently announced that it has completed the acquisition of Tosymra (sumatriptan) Nasal Spray, 10 mg, and Zembrace SymTouch (sumatriptan) Injection 3 mg from Dr. Reddy's Laboratories. (chaindrugreview.com)
  • MAPLE GROVE, Minn. , Oct. 2, 2019 /PRNewswire/ -- Upsher-Smith Laboratories, LLC (Upsher-Smith) today announced the launch of Tosymra ™ (sumatriptan) Nasal Spray, 10 mg for the acute treatment of migraine with or without aura in adults. (ptcommunity.com)
  • Available in a range of dosage and administration methods, Sumatriptan is available in tablets, nasal spray and by injection. (kiwidrug.com)
  • Avoid taking other triptan medications in conjunction with Sumatriptan, including other forms of administration such as nasal spray, without first speaking to a doctor about potential risks. (kiwidrug.com)
  • These exciting results further reinforce our belief that sumatriptan oral spray will provide significant clinical benefits to migraine sufferers including faster relief than Imitrex tablets as well as greater tolerability than triptan nasal sprays," commented Jan Egberts M.D., President and CEO of NovaDel. (salesandmarketingnetwork.com)
  • Time to the first peak plasma concentration of sumatriptan -- which represents drug absorbed directly across the oral mucosa -- was approximately 70% faster with the 20 mg oral spray than what has been reported in the literature for the same dose of the Imitrex nasal spray (6 min. (salesandmarketingnetwork.com)
  • Advantages of intranasal Imitrex administration are the rapid onset of action and high systemic absorption of the active ingredient Sumatriptan through the nasal mucosa. (healthordisease.com)
  • A clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine. (semanticscholar.org)
  • article{Boureau2000ACC, title={A clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine. (semanticscholar.org)
  • A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray (20 mg) with dihydroergotamine (DHE) nasal spray (1 mg plus optional 1 mg). (semanticscholar.org)
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  • Sumatriptan and zolmitriptan are also available as nasal sprays. (wikipedia.org)
  • but sumatriptan and zolmitriptan nasal sprays are also approved for youths over 12. (wikipedia.org)
  • Serious cardiac events, including some that have been fatal, have occurred following the use of sumatriptan injection or tablets. (wikipedia.org)
  • What is the most important information I should know about sumatriptan injection? (rexhealth.com)
  • What is sumatriptan injection? (rexhealth.com)
  • What should I discuss with my health care provider before using sumatriptan injection? (rexhealth.com)
  • To avoid exposing your baby to sumatriptan in breast milk, do not breast-feed for 12 hours after using an injection. (rexhealth.com)
  • Sumatriptan injection is not approved for use by anyone younger than 18 years old. (rexhealth.com)
  • How should I use sumatriptan injection? (rexhealth.com)
  • In the study involving healthy adult subjects, sumatriptan DosePro was bioequivalent to the needle-based autoinjector in the abdomen and thigh injection sites, and showed that maximum plasma concentrations of sumatriptan were reached rapidly, within approximately 12 minutes. (redorbit.com)
  • IMITREX Injection contains sumatriptan succinate, a selective 5-HT 1B/1D receptor agonist . (rxlist.com)
  • Each 0.5 mL of IMITREX Injection 8 mg/mL solution contains 4 mg of sumatriptan (base) as the succinate salt and 3.8 mg of sodium chloride, USP in Water for Injection, USP. (rxlist.com)
  • Now, to make aborting a Migraine fast and pain-free, the FDA has just approved the first needle-free sumatriptan injection. (healthcentral.com)
  • My consultant finally explained this to me and I was prescribed sumatriptan in injection form. (everydayhealth.com)
  • If P.O. therapy will follow subcutaneous injection, additional P.O. sumatriptan may be given q 2 hours, not to exceed 100 mg/day. (thefreedictionary.com)
  • If the headache responds to sumatriptan injection, the model can be used to test new drug candidates. (clinicaltrials.gov)
  • Hypothesis: Cilostazol induces a migraine-like headache in MO-patients and the induced headache responds to sumatriptan injection Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs. (clinicaltrials.gov)
  • Before you buy sumatriptan injection, compare prices at U.S., Canadian, and international online pharmacies. (pharmacychecker.com)
  • The most common side effects seen with subcutaneous sumatriptan are injection site reactions and triptan sensations. (dovepress.com)
  • After subcutaneous injection of sumatriptan, there was no significant change in heart rate or ECG morphology. (biomedsearch.com)
  • Mr. Turanin's presentation, which will take place at 9:30 am PT on October 23, is a case study on Zogenix's first commercialized product utilizing DosePro technology, SUMAVEL ® DosePro ® (sumatriptan injection) Needle-free Delivery System, for the acute treatment of migraine and cluster headache. (thestreet.com)
  • In developing SUMAVEL DosePro, we successfully leveraged the unique properties of the DosePro needle-free delivery system to reposition the under-utilized standard subcutaneous treatment for migraine, sumatriptan injection, into a novel treatment option that simplifies the patient experience. (thestreet.com)
  • If headache returns following initial treatment with sumatriptan injection, additional oral doses of up to 100 mg/day total may be given with intervals of at least 2 hours between each oral dose. (pdr.net)
  • Sumatriptan Injection, USP is indicated in adults for (1) the acute treatment of migraine, with or without aura, and (2) the acute treatment of cluster headache. (nih.gov)
  • The maximum single recommended adult dose of sumatriptan injection for the acute treatment of migraine or cluster headache is 6 mg injected subcutaneously. (nih.gov)
  • These highlights do not include all the information needed to use SUMATRIPTAN INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for SUMATRIPTAN INJECTION. (nih.gov)
  • ALSUMA is a prescription medication that delivers sumatriptan through subcutaneous injection supplied by a single-use, pre-filled auto-injector that requires minimal steps for use. (andhranews.net)
  • In two U.S. clinical trials involving 1,104 migraine patients with moderate or severe migraine pain, a 6-mg subcutaneous dose of sumatriptan injection resulted in a rapid onset of relief (less than 10 minutes). (andhranews.net)
  • Headache relief, as evidenced by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70 percent of patients within 1 hour of a single 6-mg subcutaneous injection of sumatriptan (compared with 18 percent [study 1] and 26 percent [study 2] receiving placebo). (andhranews.net)
  • SAN DIEGO, Dec. 10, 2013 (GLOBE NEWSWIRE) -- Zogenix, Inc. (Nasdaq:ZGNX), a pharmaceutical company developing and commercializing products for the treatment of central nervous system (CNS) disorders and pain, announced today that the U.S. Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for a 4 mg dose of SUMAVEL DosePro (sumatriptan injection) Needle-free Delivery System. (fiercepharma.com)
  • Cady continued, 'The well-established efficacy of sumatriptan injection with the benefit of increasing patient satisfaction using needle-free technology, supports the goal of optimizing migraine treatment. (fiercepharma.com)
  • Sumavel DosePro (sumatriptan injection) is a serotonin (5-HT1B/1D) receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults and the acute treatment of cluster headache in adults. (fiercepharma.com)
  • I just checked on the Inhouse Pharmacy web-site and found that sumatriptan injection prices are higher than what I can get at local pharmacies. (thedailyheadache.com)
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  • tell your doctor and pharmacist if you are allergic to sumatriptan, any other medications, or any of the ingredients in sumatriptan tablets. (medlineplus.gov)
  • Sumatriptan 50mg & 100mg Tablets are used to treat symptoms of a migraine including nausea and light sensitivity. (healthexpress.co.uk)
  • To buy Sumatriptan Tablets online, click below to fill out your details for approval and delivery. (healthexpress.co.uk)
  • What is Sumatriptan Tablets (50mg & 100mg)? (healthexpress.co.uk)
  • Sumatriptan Tablets (50mg & 100mg) typically take the form of film-coated pink or white/off-white capsule-shaped tablets. (healthexpress.co.uk)
  • Sumatriptan Tablets (50mg & 100mg) help to alleviate symptoms associated with acute migraines, such as a throbbing feeling in the head, nausea and visual disturbances. (healthexpress.co.uk)
  • How does Sumatriptan Tablets (50mg & 100mg) work? (healthexpress.co.uk)
  • The objective of this study is to compare the rate and extent of absorption of sumatriptan from a test formulation of Sumatriptan Succinate 100 mg Tablets versus the reference Imitrex® 100 mg Tablets under fasting conditions. (clinicaltrials.gov)
  • We compared the efficacy and safety of 3 doses of sumatriptan and naproxen sodium (suma/nap) combination tablets to placebo in the acute treatment of adolescent migraine. (aappublications.org)
  • To determine the efficacy and tolerability of sumatriptan plus naproxen, administered together as separate tablets or taken as a fixed-dose combination tablet, compared with placebo and other active interventions in the treatment of acute migraine attacks in adults. (cochrane.org)
  • Please read this leaflet carefully before you start taking Sumatriptan Sandoz tablets. (nps.org.au)
  • Your doctor has weighed the expected benefits of you taking Sumatriptan Sandoz tablets against the risks this medicine could have for you. (nps.org.au)
  • What are Sumatriptan Sandoz tablets used for? (nps.org.au)
  • Sumatriptan Sandoz tablets contain the active ingredient sumatriptan succinate. (nps.org.au)
  • Sumatriptan Sandoz tablets are used to relieve a migraine attack. (nps.org.au)
  • Sumatriptan Sandoz tablets work by making those vessels normal again and ease the symptoms of migraine. (nps.org.au)
  • Your Sumatriptan Sandoz tablets do not work in other types of headache which are not a migraine. (nps.org.au)
  • Sumatriptan Sandoz tablets are not addictive. (nps.org.au)
  • Each white to off-white, sugar coated round tablets, with 'P' on one side and 'S25' on the other side, contains 25 mg sumatriptan (base) as the succinate salt. (canada.com)
  • Each pink, sugar coated round tablets, with 'P' on one side and 'S100' on the other side, contains 100 mg sumatriptan (base) as the succinate salt. (canada.com)
  • Sumatriptan tablets should not be chewed but swallowed whole with some water. (dokteronline.com)
  • Sumatriptan is available as tablets of 50 mg and 100 mg. (dokteronline.com)
  • Sumatriptan tablets are not recommended in people under 18 and over 65 years of age. (dokteronline.com)
  • SUMATRIPTAN AN Tablets are indicated for the acute relief of migraine attacks with or without aura. (healthdirect.gov.au)
  • You have successfully added Sumatriptan tablets 100mg 6 to your basket. (mistrys.co.uk)
  • If you're looking to save on Imitrex or Treximet, check into pricing at Inhouse Pharmacy Europe , which has 50 mg tablets of sumatriptan for $1.10 each. (thedailyheadache.com)
  • Like all medicines, Sumatriptan tablets can have Side Effects, although not everybody gets them. (medical-specialists.co.uk)
  • The product discussed on this page is sumatriptan tablets. (kiwidrug.com)
  • Results from this pilot study demonstrate that sumatriptan oral spray achieves a statistically significant faster rate of absorption than Imitrex tablets. (salesandmarketingnetwork.com)
  • Sumatriptan oral spray was evaluated in a four-arm, crossover pharmacokinetic study comparing 50 mg Imitrex tablets to 20 mg and 30 mg of the oral spray in 10 healthy male volunteers under fasting conditions. (salesandmarketingnetwork.com)
  • At least 90% of subjects receiving sumatriptan oral spray had detectable drug levels at three minutes post-dosing, while at the same timepoint, only 10% of subjects receiving 50 mg Imitrex tablets had detectable drug levels. (salesandmarketingnetwork.com)
  • geneesmiddel sumatriptan over the counter substitute for sumatriptan, sumatriptan tablets online, sumatriptan 100mg kaufen, sumatriptan kostprijs? (bairescore.com)
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  • Can I split 50mg or 100mg of Sumatriptan in half? (drugs.com)
  • Has anyone had Bad reactions to the combination of Sertraline 100mg sumatriptan tramadol & opiates? (drugs.com)
  • In the 48 hour period following ED treatment for a primary headache, sumatriptan 100mg will relieve pain better than naproxen 500mg, as measured by an 11-point numerical rating scale for pain. (clinicaltrials.gov)
  • It has been seen that 10mg rizatriptan is much more effective than a 50 or 100mg of sumatriptan. (differencebetween.net)
  • It is usually taken at the first sign of a migraine headache.If your symptoms improve after you take sumatriptan but return after 2 hours or longer, you may take a second tablet. (medlineplus.gov)
  • Take sumatriptan exactly as directed. (medlineplus.gov)
  • If you take sumatriptan more often or for longer than the recommended period of time, your headaches may get worse or may occur more frequently. (medlineplus.gov)
  • You should not take sumatriptan or any other headache medication for more than 10 days per month. (medlineplus.gov)
  • Call your doctor if you need to take sumatriptan to treat more than four headaches in a 1-month period. (medlineplus.gov)
  • do not take sumatriptan if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) or if you have taken one of these medications in the past 2 weeks. (medlineplus.gov)
  • Can you take sumatriptan on an empty stomach? (drugs.com)
  • Many people find that their headaches go away completely after they take sumatriptan. (mayoclinic.org)
  • Who should take sumatriptan? (sharecare.com)
  • Do not take sumatriptan for longer than prescribed for, as this can worsen your headaches. (sharecare.com)
  • Elderly people should not take sumatriptan, as they have an increased risk of heart complications. (sharecare.com)
  • How should I take sumatriptan and naproxen? (adventisthealthcare.com)
  • Take Sumatriptan only when you have a migraine attack. (mistrys.co.uk)
  • Do not take Sumatriptan if you do not have a migraine attack. (mistrys.co.uk)
  • Alert your doctor if you frequently have migraine attacks which require you to take Sumatriptan, especially if you have more than 4 migraine headaches in a 30-day period. (mistrys.co.uk)
  • Do not take Sumatriptan if you have already taken similar migraine medicine such as eletriptan, naratriptan, rizatriptan or zolmitriptan in the last 24 hours. (mistrys.co.uk)
  • Do not take Sumatriptan if you have taken any migraine medicine which contains ergotamine or methysergide in the last 24 hours. (mistrys.co.uk)
  • Hello Dear, Do not worry,you have typical symptoms of migraine.What treatment are you on?Avoid stress and relax.You can take some NSAID to relieve the pain.If the pain is of increased intensity you can take sumatriptan. (medhelp.org)
  • Last month the U.S. Food and Drug Administration (FDA) approved Treximet (sumatriptan and naproxen sodium) for use in pediatric patients 12 years of age and older for the acute treatment of migraine with or without aura. (headaches.org)
  • In potential good news for adolescent migraineurs, the U.S. Food and Drug Administration has accepted a supplemental New Drug Application (sNDA) for Treximet, a combination medication containing sumatriptan and naproxen sodium. (headaches.org)
  • LONDON, April 17 -- A tablet that combines sumatriptan and naproxen (Treximet) has been approved by the FDA for treatment of migraine with and without aura, GlaxoSmithKline announced here. (medpagetoday.com)
  • If you use Treximet, you can try taking sumatriptan with 500 mg of the OTC painkiller naproxen sodium (Aleve) to approximate the drug. (thedailyheadache.com)
  • Treximet contains 85 mg of sumatriptan, while sumatriptan only comes in 50 mg and 100 mg, so you'll have to choose which you prefer. (thedailyheadache.com)
  • Wherever you buy sumatriptan, you can try to simulate the effect of Treximet by taking naproxen sodium (Aleve) along with it. (thedailyheadache.com)
  • See paragraph five of Save Money on Sumatriptan (Imitrex/Imigran/Treximet) for details. (thedailyheadache.com)
  • I didn't know about mixing sumatriptan with naproxen sodium to make treximet. (thedailyheadache.com)
  • Can you take Delayed release tramadol 50mg (2/day) and sumatriptan 50mg (as needed) together? (drugs.com)
  • Sumatriptan - how often is it safe to take sumatripan 50mg? (drugs.com)
  • Sumatriptan is in a class of medications called selective serotonin receptor agonists. (medlineplus.gov)
  • Sumatriptan is structurally similar to serotonin (5-HT), and is a 5-HT receptor (types 5-HT1D and 5-HT1B) agonist. (wikipedia.org)
  • Sumatriptan may cause a serious condition called serotonin syndrome when used with some medicines. (mayoclinic.org)
  • Sumatriptan is a selective serotonin receptor agonist used to relieve the symptoms of migraine headaches. (patientslikeme.com)
  • These medicines may interact with sumatriptan and cause a serious condition called serotonin syndrome. (wellspan.org)
  • As sumatriptan has a similar structure to serotonin, it can bind to a type of serotonin receptor and activate the pathways. (sciencephoto.com)
  • Sumatriptan is a serotonin receptor agonist that works in the brain to relieve migraine headaches. (adam.com)
  • Sumatriptan works by stimulating receptors called serotonin (or 5HT) receptors that are found in the brain. (medical-specialists.co.uk)
  • Other common side effects of Sumatriptan include nausea, vomiting, muscle weakness, flushing, throat tightness, dry mouth and a tingling or burning sensation. (mistrys.co.uk)
  • Sumatriptan does not prevent migraine attacks or reduce the number of headaches you have. (medlineplus.gov)
  • Sumatriptan does not prevent migraine attacks. (patientslikeme.com)
  • A form of salt, Sumatriptan (the active ingredient) is most often used to treat acute migraine attacks. (healthexpress.co.uk)
  • The combination of sumatriptan plus naproxen was useful for treating migraine attacks in the studies we found. (cochrane.org)
  • The combination of sumatriptan plus naproxen was better than placebo for relieving acute migraine attacks in adults. (cochrane.org)
  • Sumatriptan is a painkiller that is specifically used for migraine attacks. (dokteronline.com)
  • Sumatriptan is one of the triptan family of drugs used to treat migraine attacks. (cochrane.org)
  • Oral sumatriptan is effective as an abortive treatment for migraine attacks, relieving pain, nausea, photophobia, phonophobia, and functional disability, but is associated with increased adverse events. (cochrane.org)
  • Sumatriptan is an abortive medication for migraine attacks, belonging to the triptan family. (cochrane.org)
  • To determine the efficacy and tolerability of oral sumatriptan compared to placebo and other active interventions in the treatment of acute migraine attacks in adults. (cochrane.org)
  • Sumatriptan should not be taken to prevent or reduce the number of migraine attacks. (mistrys.co.uk)
  • Zogenix has announced successful results from two clinical studies of sumatriptan DosePro, a product in development for treatment of acute migraine and cluster headache. (redorbit.com)
  • The first clinical study evaluated the pharmacokinetics, bioequivalence and safety of needle-free sumatriptan DosePro, compared to a needle-based autoinjector, Imitrex STATdose used in the treatment of migraine. (redorbit.com)
  • Sumatriptan DosePro and Imitrex STATdose treatments also exhibited highly similar safety profiles. (redorbit.com)
  • The second study, in which patients at home used sumatriptan DosePro as their primary means of treating migraine headache, demonstrated that 98% of patients were able to correctly use the simple three-step DosePro technology on their first try, even in the midst of an acute migraine attack. (redorbit.com)
  • DosePro is a first-of-its-kind needle-free delivery system for subcutaneous sumatriptan, a treatment that provides migraine relief within 10 minutes for some patients. (healthcentral.com)
  • Sumavel DosePro will be a welcome treatment option because it combines key benefits - the rapid efficacy of subcutaneous sumatriptan and a simple to use needle-free delivery system. (healthcentral.com)
  • SUMAVEL DosePro is contraindicated in patients with uncontrolled hypertension, in patients with history, symptoms or signs of ischemic heart disease, coronary artery vasospasm, cerebrovascular or peripheral vascular disease including ischemic bowel disease and in patients with other significant underlying cardiovascular diseases or known hypersensitivity to sumatriptan. (thestreet.com)
  • SUMAVEL DosePro is the first and only needle-free delivery system for subcutaneous sumatriptan for the treatment of acute migraine and cluster headache. (fiercepharma.com)
  • Sumatriptan and rizatriptan belong to this class and are commonly used in treatment of migraine. (differencebetween.net)
  • Sumatriptan and rizatriptan when taken orally, take some amount of time to be absorbed into the blood stream and reach the brain to act. (differencebetween.net)
  • The time taken for the drug to reach the blood and become available to the tissues is much lesser in rizatriptan than sumatriptan. (differencebetween.net)
  • Rizatriptan is available within an hour as compared to sumatriptan that takes about 2-2.5 hours. (differencebetween.net)
  • Due to this, rizatriptan has a faster onset of relief compared to sumatriptan. (differencebetween.net)
  • Sumatriptan takes about an hour for onset of action as compared to rizatriptan which takes about 30 minutes. (differencebetween.net)
  • Rizatriptan does not have a sulphur group in its basic chemical structure which is present in sumatriptan. (differencebetween.net)
  • Sumatriptan and rizatriptan are part of the Triptans class of drugs used in treatment of migraine. (differencebetween.net)
  • Sumatriptan was the pioneer drug , later other triptans like rizatriptan were produced. (differencebetween.net)
  • Rizatriptan is faster acting compared to sumatriptan. (differencebetween.net)
  • In spite of expert opinion and evidence to the contrary, the FDA and some other drug governance bodies have stated that monoamine oxidase inhibitors are contraindicated for sumatriptan, zolmitriptan and rizatriptan, and combination with ergot alkaloids such as ergotamine for all substances. (wikipedia.org)
  • Sumatriptan is used to treat acute migraine headaches in adults. (mayoclinic.org)
  • Sumatriptan is indicated for the acute treatment of migraine , with or without aura , and the acute treatment of cluster headache . (rxlist.com)
  • Sumatriptan plus naproxen is now available in combination form for the acute treatment of migraine. (cochrane.org)
  • Sumatriptan NS is effective and well-tolerated for the treatment of acute migraine in adolescents, with the 20-mg dose providing the best overall efficacy and tolerability profiles. (aappublications.org)
  • Subcutaneous sumatriptan is an effective treatment for pain from acute migraine headache, and can be used in patients with known migraine syndrome and in patients with primary headaches when secondary causes have been excluded. (dovepress.com)
  • Subcutaneous sumatriptan is a good first-line agent for the treatment of pain from acute migraine headaches and primary headaches. (dovepress.com)
  • BACKGROUND: Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. (biomedsearch.com)
  • The objective of this study is to compare the efficacy and tolerability of intravenous valproic acid (iVPA) with intramuscular metoclopramide + subcutaneous (SQ) sumatriptan for prolonged acute migraine. (sigmaaldrich.com)
  • To treat severe, acute migraine headaches (sumatriptan is not effective against any other kinds of pain or headache). (holisticonline.com)
  • Hi, Oxygen and sumatriptan have been demonstrated to be effective in the acute treatment of cluster headaches. (medhelp.org)
  • SUMATRIPTAN (soo ma TRIP tan) is used to treat migraines with or without aura. (ahealthyme.com)
  • Sumatriptan injections are used for the treatment of migraines. (pharmac.govt.nz)
  • Though Sumatriptan is effective against migraines and cluster headaches, it will not significantly reduce pain or symptoms in any other types of headaches. (kiwidrug.com)
  • Some individuals find Sumatriptan gradually becomes less effective at combating migraines. (kiwidrug.com)
  • Triptans such as Sumatriptan are used to treat migraine headaches. (dokteronline.com)
  • As with all triptans, there is a risk of rare cardiovascular events with subcutaneous sumatriptan and its use should be limited to those without known cerebrovascular disease and limited in those with known cardiovascular risk factors and unknown disease status. (dovepress.com)
  • Sumatriptan and newer generation triptans are also effective for migraine. (sigmaaldrich.com)
  • Mylan and try other triptans that come in a generic form - Imitrex (sumatriptan), Amerge (naratriptan), and Zomig (zolmitriptan). (nyheadache.com)
  • Sumatriptan was the first of the triptans to be used and the others followed. (differencebetween.net)
  • Sumatriptan comes as a tablet to take by mouth. (medlineplus.gov)
  • The drug delivers 85 mg of sumatriptan -- already used for migraine (Imitrex) -- with 500 mg of naproxen, in a single tablet that the company said targets "multiple mechanisms of migraine. (medpagetoday.com)
  • Each white to off-white, round biconvex tablet, with a logo on one side and 'SA' over '25' on the other, contains sumatriptan succinate 25 mg. (canada.com)
  • Each pink, triangular shaped biconvex tablet, with a logo on one side and 'SA' over '100' on the other, contains sumatriptan succinate 100 mg. (canada.com)
  • Combination Tablet: 85 milligrams (mg) sumatriptan and 500 mg naproxen sodium. (clinicaltrials.gov)
  • The generic sumatriptan was released four years ago and now the price of one tablet is down to about $3 from over $20. (nyheadache.com)
  • Intranasal sumatriptan powder seems to be a new and very promising way to deliver a migraine drug. (nyheadache.com)
  • This has been demonstrated for subcutaneous sumatriptan and intranasal zolmitriptan, the former of which is more effective according to a 2013 Cochrane review. (wikipedia.org)
  • Using sumatriptan alone or in combination with other migraine medicines for 10 or more days per month may lead to worsening of headache. (mayoclinic.org)
  • Sumatriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound. (mayoclinic.org)
  • You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. (rexhealth.com)
  • Do not use sumatriptan within 24 hours before or after using another migraine headache medicine. (rexhealth.com)
  • Sumatriptan is a headache medicine that narrows blood vessels around the brain. (rexhealth.com)
  • Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. (rexhealth.com)
  • Sumatriptan will only treat a headache that has already begun. (rexhealth.com)
  • Sumatriptan should not be used to treat a common tension headache or a headache that causes loss of movement on one side of your body. (rexhealth.com)
  • Sumatriptan is not recommended for other types of headache or for headache prevention. (medbroadcast.com)
  • The goal of this study is to compare two medications, naproxen and sumatriptan, to determine which is better for the treatment of recurrent headache within 24 hours of emergency department discharge. (clinicaltrials.gov)
  • Sumatriptan will only treat a headache. (wellspan.org)
  • On 28 October 2015, we looked for clinical trials using sumatriptan plus naproxen to treat migraine headache in adults. (cochrane.org)
  • Sumatriptan should be taken as early as possible after the migraine headache has started, though it is also effective if taken at a later stage during the migraine attack. (dokteronline.com)
  • To validate this model, the headache must respond to specific migraine treatment with sumatriptan. (clinicaltrials.gov)
  • We included randomised, double- blind , placebo - and/or active-controlled studies using oral sumatriptan to treat a migraine headache episode, with at least 10 participants per treatment arm. (cochrane.org)
  • For sumatriptan 50 mg versus placebo the NNTs were 6.1, 7.5, and 4.0 for pain-free at two hours and headache relief at one and two hours, respectively. (cochrane.org)
  • Results for the 25 mg dose were similar to the 50 mg dose, while sumatriptan 100 mg was significantly better than 50 mg for pain-free and headache relief at two hours, and for sustained pain-free during 24 hours. (cochrane.org)
  • The primary efficacy endpoint was headache relief 2 hours postdose sumatriptan NS (20 mg) versus placebo. (aappublications.org)
  • Each dose of sumatriptan (5 mg, 10 mg, and 20 mg) was superior to placebo with respect to the cumulative percentages of patients first reporting headache relief within 2 hours of dosing (Kaplan-Meier). (aappublications.org)
  • Sumatriptan should be taken at the first sign of a migraine headache. (mistrys.co.uk)
  • Do not use Sumatriptan for any other purpose other than to relieve a migraine headache. (mistrys.co.uk)
  • Sumatriptan is a migraine headache medicine. (johnstonhealth.org)
  • Subcutaneous sumatriptan is a very effective symptomatic treatment for cluster headache pain attacks, this confirming that trigemino-vascular activation with cranial vasodilatation or plasma protein extravasation are the pathophysiological explanation for cluster headache attacks. (bmj.com)
  • A randomized open-label study of sodium valproate vs sumatriptan and metoclopramide for prolonged migraine headache. (sigmaaldrich.com)
  • Headache relief within 1 hour (defined as a reduction in pain from severe or moderately severe to mild or no headache) was achieved in 73% of patients who received a single 6 mg subcutaneous dose of sumatriptan compared to 50% of patients who received a single 4 mg subcutaneous dose. (pdr.net)
  • Thanks to The Daily Headache reader on Facebook who told me about HealthWarehouse's price on sumatriptan. (thedailyheadache.com)
  • Sumatriptan is an abortive medication, which means it stops a headache in progress. (kiwidrug.com)
  • Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. (wikipedia.org)
  • Sumatriptan may also be used for purposes not listed in this medication guide. (rexhealth.com)
  • Consult a doctor on the use of Sumatriptan if you have a health condition that is not listed above, are taking medication, smoke cigarettes or are older than 40 years of age. (dokteronline.com)
  • Sumatriptan succinate ( Alsuma ™, Imitrex ® , Sumavel ® , Zecuity ™) is a prescription medication that is used to treat migraine headaches . (emedtv.com)
  • We are the UK's leading supplier of pain killer medication, and Sumatriptan for sale in the UK. (medical-specialists.co.uk)
  • Sumatriptan is the generic name for the first migraine medication in the triptan class of drugs. (kiwidrug.com)
  • Subcutaneous sumatriptan stopped the attacks in less than 15 minutes. (bmj.com)
  • In addition, during the bouts, when she experienced multiple consecutive pain attacks, the patient noticed that after subcutaneous sumatriptan she was free of pain for a maximum of 8 hours and a minimum of 6 hours. (bmj.com)
  • 2 Subcutaneous sumatriptan consistently relieved her chronic paroxysmal hemicrania attacks in less than 15 minutes and protected her from further pain attacks for 6 to 8 hours. (bmj.com)
  • Pharmaceutical companies were given the opportunity to register their own trademarks for Sumatriptan, as well as to produce a drug under a generic name. (healthordisease.com)
  • Tosymra, which utilizes Intravail ® technology, efficiently delivers sumatriptan intranasally and achieves median peak plasma concentration five minutes faster than injectable sumatriptan, 4 mg and 6 mg. (ptcommunity.com)
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  • Malaise/fatigue occurred in less than 1% of the placebo group and 2-3% of the sumatriptan groups. (wikipedia.org)
  • Sleep disturbance occurred in less than 1% in the placebo group to 2% in the sumatriptan group. (wikipedia.org)
  • Compared with monotherapy with sumatriptan or naproxen or placebo, the combination pill provided better pain relief at two and four hours, the company said. (medpagetoday.com)
  • People were given either a combination of sumatriptan and naproxen, sumatriptan only, naproxen only, or a placebo (dummy) treatment. (cochrane.org)
  • Adverse events of dizziness, tingling or burning of the skin, sleepiness (somnolence), nausea, indigestion (dyspepsia), dry mouth, and chest discomfort were more common with sumatriptan (alone or in combination) than with placebo or naproxen. (cochrane.org)
  • Adverse events were more common with the combination and sumatriptan alone than with placebo or naproxen alone. (cochrane.org)
  • Sixty-one studies (37,250 participants) compared oral sumatriptan with placebo or an active comparator. (cochrane.org)
  • Sumatriptan surpassed placebo for all efficacy outcomes. (cochrane.org)
  • For the most part, adverse events were transient and mild and were more common with the sumatriptan than with placebo , with a clear dose response relationship (25 mg to 100 mg). (cochrane.org)
  • Complete relief 2 hours postdose was significantly greater for patients using 20 mg of sumatriptan NS compared with placebo (36% vs 25%, respectively). (aappublications.org)
  • Photophobia and phonophobia were significantly reduced 2 hours postdose for sumatriptan NS (20 mg), compared with placebo (36% vs 48% and 25% vs 44%, respectively). (aappublications.org)
  • In a study of 117 patients, 57% were pain-free and 80% had pain relief 2 hours after receiving 20 mg of sumatriptan powder, which was very significantly better than with placebo. (nyheadache.com)
  • The four treatment groups of interest (with and without nausea at baseline and using sumatriptan TDS or placebo) were very similar from a demographic standpoint ( Table ). (cbw.com)
  • A total of 130 participants treated with sumatriptan TDS and 109 participants treated with placebo did not have nausea at the time of treatment and were analyzed for TEN. (cbw.com)
  • Proportion of patients with treatment-emergent nausea after treatment with sumatriptan or placebo transdermal systems (TDSs). (cbw.com)
  • The incidence of treatment-emergent nausea over 24 hours post-treatment was statistically significantly lower with the sumatriptan TDS than with placebo ( P = .0011). (cbw.com)
  • 2.1% of those receiving sumatriptan TDS vs 1.3% in those receiving placebo discontinued the study. (cbw.com)
  • Triptan sensations were experienced by 3.4% of patients treated with the sumatriptan TDS (1.7% atypical sensations and 1.7% pain and other pressure sensations) vs 0.4% for placebo. (cbw.com)
  • Sumatriptan comes as a spray (Imitrex, Tosymra) to inhale through the nose. (medlineplus.gov)
  • If your symptoms improve after you use sumatriptan but come back, you may use a second dose of sumatriptan (Imitrex, Onzetra Xsail) at least 2 hours later, or a second or third dose of sumatriptan (Tosymra) at least 1 hour after each other, if needed. (medlineplus.gov)
  • In limited comparative trials, subcutaneous sumatriptan performed in a manner comparable with oral eletriptan and intravenous metoclopramide, was superior to intravenous aspirin and intramuscular trimethobenzamide-diphenhydramine, and was inferior to intravenous prochlorperazine for pain relief. (dovepress.com)
  • ALSUMA auto-injector is a prescription medicine that contains sumatriptan and is used to treat adults who have been diagnosed with migraine or cluster headaches. (andhranews.net)
  • Sumatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea or sensitivity to sound and light). (medlineplus.gov)
  • Call your doctor if your headaches do not get better or occur more frequently after taking sumatriptan. (medlineplus.gov)
  • Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches. (wikipedia.org)
  • Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which presumably accounts for sumatriptan's efficacy in treating cluster headaches. (wikipedia.org)
  • Sumatriptan works in the brain to relieve the pain from migraine headaches. (mayoclinic.org)
  • Sumatriptan is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers. (drugs.com)
  • Sumatriptan and naproxen is a combination medicine used to treat migraine headaches. (adventisthealthcare.com)
  • Sumatriptan relieves migraine headaches by constricting these blood vessels. (medbroadcast.com)
  • The VISX patient information booklet lists, in its 'discuss these conditions with your doctor' section: 'Take medicines that might make it harder for wounds to heal, such as Sumatriptan ([email protected]*) used for migraine headaches, because it is unknown whether LASIK is safe and effective for this condition. (usaeyes.org)
  • Sumatriptan is licensed to relieve symptoms of migraine headaches. (emedtv.com)
  • Imitrex ( sumatriptan ) is usually prescribed to combat migraine headaches and associated symptoms, such as auras. (kiwidrug.com)
  • Of participants treated with sumatriptan TDS, 130 had no nausea, whereas 96 had nausea at baseline when treated (Table). (cbw.com)
  • Proportion of patients with or without nausea at baseline that were pain-free (A) or had pain relief (B) after treatment with sumatriptan transdermal system. (cbw.com)
  • Tolerability was virtually identical in individuals receiving sumatriptan TDS independent of nausea at baseline (Fig. 5). (cbw.com)
  • AE after sumatriptan TDS occurred in 51% of individuals with nausea at baseline vs 50.4% of those without nausea. (cbw.com)
  • Tolerability among individuals receiving sumatriptan transdermal system (TDS) as a function of nausea at baseline. (cbw.com)
  • Tell your doctor if you have ever had any unusual or allergic reaction to sumatriptan or any other medicines. (drugs.com)
  • When you are taking sumatriptan, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)
  • Using sumatriptan with any of the following medicines is not recommended. (drugs.com)
  • Using sumatriptan with any of the following medicines is usually not recommended, but may be required in some cases. (drugs.com)
  • Sumatriptan and certain other medicines can affect each other, causing serious side effects. (lannett.com)
  • Some foods and medicines can affect how sumatriptan works. (limamemorial.org)
  • The active ingredient sumatriptan relieves pain by causing the blood vessels in the brain to narrow. (dokteronline.com)
  • Sumatriptan works by narrowing these blood vessels, helping them return to their normal state. (emedtv.com)
  • It appears that sumatriptan activates chemical rnessengers that cause blood vessels in the brain to constrict, thus lessening the effects of a migraine. (holisticonline.com)
  • Sumatriptan has a powerful constricting effect on the heart and blood vessels and as a result has caused fatal heart spasms and possibly fatal strokes. (holisticonline.com)
  • geneesmiddel sumatriptan Bird City, sumatriptan succinate cost, sumatriptan aurobindo 50 mg kosten, amitriptyline prices , sumatriptan over the counter, sumatriptan pret, brand name of sumatriptan in india. (bairescore.com)
  • Sumatriptan - Why do they limit to 9 doses per month? (drugs.com)
  • Do not take more than 2 doses of Sumatriptan in a 24-hour period. (mistrys.co.uk)
  • From 1 February 2017 the brand name of the fully subsidised sumatriptan injections will change from Sun-Pharma to Clustran . (pharmac.govt.nz)
  • From 1 July 2017 the sumatriptan injections branded Sun-Pharma will no longer be available, only the Clustran branded injections will be fully funded . (pharmac.govt.nz)
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  • Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which manufactures sumatriptan and naproxen sodium and funded the study. (empr.com)
  • This paradox has, to some extent, been resolved by comparing the rates of absorption of the various sumatriptan formulations, rather than the absolute amounts of drug that they deliver. (wikipedia.org)
  • The pharmaceutical company NuPathe Inc. resubmitted its New Drug Application to the U.S. Food and Drug Administration (FDA) last month for its sumatriptan migraine patch, NP101, also known as Zelrix. (headaches.org)
  • The release of a generic substitute of the branded drug Imitrex (sumatriptan) has dramatically reduced the cost and improved the access to this uniquely effective migraine drug. (nyheadache.com)
  • Sumatriptan is a prescription drug and an effective painkiller specifically used as a migraine treatment . (medical-specialists.co.uk)
  • Sumatriptan is a sulfa drug and should not be used by individuals who are hypersensitive to sulfa. (kiwidrug.com)
  • Sumatriptan was much more effective than the anti-migraine drug Ergotamine that was mainly used back then, and did not cause any significant side effects. (healthordisease.com)
  • A single randomized controlled trial found that sumatriptan may be able to prevent altitude sickness. (wikipedia.org)
  • What should I discuss with my healthcare provider before taking naproxen and sumatriptan? (johnstonhealth.org)
  • These conditions can occur without warning while you are using naproxen and sumatriptan, especially in older adults. (johnstonhealth.org)
  • Do not use naproxen and sumatriptan if you have used an MAO inhibitor in the past 14 days. (johnstonhealth.org)
  • Naproxen and sumatriptan is not approved for use by anyone younger than 12 years old. (johnstonhealth.org)
  • What Other Drugs Interact with Sumatriptan? (rxlist.com)
  • This leaflet answers some common questions about sumatriptan. (news-medical.net)
  • You have had an allergic reaction to sumatriptan succinate or any of the ingredients listed at the end of this leaflet. (news-medical.net)
  • For full patient information, please read or print out the leaflet provided at the bottom of this page about Sumatriptan. (medical-specialists.co.uk)