Sulfones. Medical search

A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.

Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

A group of compounds that contain the structure SO2NH2.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. (1/2198)

Wild-type (wt) p53 frequently induces apoptosis when expressed in tumor cells whereas mutant p53 acts as an oncoprotein and consequently, stimulates cell proliferation. We report here exceptions to that rule. p53 conformational mutant 175H and DNA contact mutant 273H provoke apoptosis in human p53-deficient Hep3B hepatoma cells with delayed kinetics relative to wt p53. Similarly, c-Myc strongly stimulates apoptosis in these cells. In contrast, viral oncoproteins E1A and E7, and the cellular oncoprotein MDM-2, fail to elicit cytocidal responses. Efficient apoptotic cell death by mutant p53 requires oligomerization as 175H and 273H with deletions between amino acid residues 326 and 347 of the oligomerization domain are nontoxic. Apoptosis by mutant or wt p53 was significantly inhibited by the serine protease inhibitor AEBSF but not by the inactive analog AEBSA. Together, these results suggest that a wt p53-independent control mechanism is operational in Hep3B cells that eliminates cells upon sensing illegitimate proliferation signals originating from certain oncoproteins, including mutant p53 and Myc. We suggest that some tumor cell types lack p53 altogether because they tolerate neither wild-type nor mutant forms of the protein. (+info)

Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). (2/2198)

1. Adenosine influences the vectorial transport of Na+ and HCO3- across kidney epithelial cells. However, its action on effector proteins, such as the Na+-H+ exchanger NHE3, an epithelial brush border isoform of the Na+-H+ exchanger (NHE) gene family, is not yet defined. 2. The present study was conducted in Xenopus laevis distal nephron A6 epithelia which express both an apical adenosine receptor of the A1 type (coupled to protein kinase C (PKC)) and a basolateral receptor of the A2 type (coupled to protein kinase A (PKA)). The untransfected A6 cell line expresses a single NHE type (XNHE) which is restricted to the basolateral membrane and which is activated by PKA. 3. A6 cell lines were generated which express exogenous rat NHE3. Measurements of side-specific pHi recovery from acid loads in the presence of HOE694 (an inhibitor with differential potency towards individual NHE isoforms) detected an apical resistant Na+-H+ exchange only in transfected cell lines. The sensitivity of the basolateral NHE to HOE694 was unchanged, suggesting that exogenous NHE3 was restricted to the apical membrane. 4. Stimulation of the apical A1 receptor with N 6-cyclopentyladenosine (CPA) inhibited both apical NHE3 and basolateral XNHE. These effects were mimicked by the addition of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and partially prevented by the PKC inhibitor calphostin C which also blocked the effect of PMA. 5. Stimulation of the basolateral A2 receptor with CPA inhibited apical NHE3 and stimulated basolateral XNHE. These effects were mimicked by 8-bromo-cAMP and partially prevented by the PKA inhibitor H89 which entirely blocked the effect of 8-bromo-cAMP. 6. In conclusion, CPA inhibits rat NHE3 expressed apically in A6 epithelia via both the apical PKC-coupled A1 and the basolateral PKA-coupled A2 adenosine receptors. (+info)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (3/2198)

OBJECTIVE: We have studied the mechanisms underlying the positive inotropic action of prostaglandin F2 alpha (PGF2 alpha) by monitoring intracellular calcium transients, intracellular pH, L-type calcium currents and cell shortening in isolated ventricular myocytes. METHODS: Rat myocytes were loaded with fura-2AM for intracellular calcium measurements, or BCECF-AM for pH measurements. Cell shortening was recorded using an edge detection system, and L-type calcium currents measured using whole cell patch clamping. RESULTS: PGF2 alpha (3 nmol l-1-3 mumol l-1 increased single myocyte shortening and reduced resting cell length in a concentration-dependent manner. While myocyte shortening was increased by PGF2 alpha, this was not associated with any change in the amplitude of intracellular calcium transients, diastolic calcium, or L-type calcium currents. However, the same myocytes were capable of responding to catecholamines with increases in calcium transient amplitude and L-type calcium currents. PGF2 alpha (3 mumol l-1 caused a reversible rise in intracellular pH of 0.08 +/- 0.01 pH units (n = 5, p < 0.05). The Na(+)-H+ exchanger inhibitor, HOE 694 (10 mumol l-1, abolished the PGF2 alpha-induced rise in pH and the increase in cell shortening. PGF2 alpha-induced increases in cell shortening and intracellular pH were also attenuated by the protein kinase C (PKC) inhibitor, chelerythrine (2 mumol l-1. CONCLUSION: The positive inotropic action of PGF2 alpha appears to be mediated via activation of the Na(+)-H+ exchanger with the possible involvement of PKC. This suggests that PGF2 alpha-produces intracellular alkalosis, which then sensitizes cardiac myofilaments to calcium. (+info)

Implication of endogenous nitric oxide in gastric mucosal protective effect of T-593, a novel anti-ulcer agent, in rats. (4/2198)

The relationship of endogenous nitric oxide (NO) to the gastric mucosal protective effect of the novel anti-ulcer agent T-593, (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5-(methylamino) methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine, was investigated in rats. T-593 (3-30 mg/kg, p.o.) dose dependently prevented the formation of gastric mucosal lesions induced by oral administration of aspirin (200 mg/kg) in 0.15 N HCl (HCl-aspirin). Pretreatment with N(G)-nitro-L-arginine methylester (L-NAME), a selective inhibitor of NO synthase (NOS), attenuated the mucosal protective effect of T-593. This effect of L-NAME was antagonized by pretreatment with L-arginine, a substrate of NOS, but not with D-arginine. Activity of total NOS composed of inducible and constitutive NOS in the gastric mucosa was decreased by HCl-aspirin, and T-593 inhibited this decrease. On the other hand, HCl-aspirin and T-593 did not affect inducible NOS activity in the gastric mucosa. Furthermore, we confirmed that T-593 inhibits the decrease in gastric mucosal blood flow (GMBF) induced by HCl-aspirin, and this effect is completely inhibited by pretreatment with L-NAME. These results suggest that the mucosal protective effect of T-593 is partly mediated by endogenous NO via improvement of GMBF and that a possible mechanism for the effect of T-593 is the maintenance of constitutive NOS activity in gastric mucosa. (+info)

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. (5/2198)

We investigated the cytochrome P-450-dependent metabolism of 1, 1-dichloroethylene (DCE) by human lung and liver microsomes and compared the results from analogous experiments in mice. Metabolites were identified by HPLC analysis of their glutathione conjugates and/or hydrolyzed products and were detected by using [14C]DCE. The role of human CYP2E1 in the metabolic reactions was examined by comparing p-nitrophenol hydroxylase activities with levels of metabolites formed and by using the CYP2E1-selective inhibitor diallyl sulfone. The major products formed in microsomal incubations containing NADPH were the DCE-epoxide-derived glutathione conjugates 2-(S-glutathionyl)acetyl glutathione and 2-S-glutathionyl acetate. Lower levels of the acetal of 2,2-dichloroacetaldehyde were also detected. In lung samples from eight patients, the amounts of epoxide-derived conjugates formed ranged from 15.6 +/- 4.23 to 34.9 +/- 12.75 pmol/mg protein/min. The levels in murine lung were higher at 40.0 +/- 3.8 pmol/mg protein/min. In liver samples from five patients, conjugate levels ranged from 46.5 +/- 8.3 to 240.0 +/- 10. 5 pmol/mg protein/min, whereas levels in murine liver were 83.0 +/- 6.2 pmol/mg protein/min. Conjugate levels formed in human liver correlated with the relative levels of p-nitrophenol hydroxylase activity present, but this relationship was equivocal in human lung. Diallyl sulfone inhibited the formation of the glutathione conjugates (20-65%) in liver samples from all four patients, whereas only one of five human lung samples exhibited this inhibition (27%). These results demonstrated that the DCE-epoxide is a major metabolite formed by human microsomes and is mediated by CYP2E1 in liver and in some individuals in lung. (+info)

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. (6/2198)

Conventional nonsteroidal anti-inflammatory drugs inhibit both cyclooxygenase (Cox) isoforms (Cox-1 and Cox-2) and may be associated with nephrotoxicity. The present study was undertaken to assess the renal effects of the specific Cox-2 inhibitor, MK-966. Healthy older adults (n = 36) were admitted to a clinical research unit, placed on a fixed sodium intake, and randomized under double-blind conditions to receive the specific Cox-2 inhibitor, MK-966 (50 mg every day), a nonspecific Cox-1/Cox-2 inhibitor, indomethacin (50 mg t.i.d.), or placebo for 2 weeks. All treatments were well tolerated. Both active regimens were associated with a transient but significant decline in urinary sodium excretion during the first 72 h of treatment. Blood pressure and body weight did not change significantly in any group. The glomerular filtration rate (GFR) was decreased by indomethacin but was not changed significantly by MK-966 treatment. Thromboxane biosynthesis by platelets was inhibited by indomethacin only. The urinary excretion of the prostacyclin metabolite 2,3-dinor-6-keto prostaglandin F1alpha was decreased by both MK-966 and indomethacin and was unchanged by placebo. Cox-2 may play a role in the systemic biosynthesis of prostacyclin in healthy humans. Selective inhibition of Cox-2 by MK-966 caused a clinically insignificant and transient retention of sodium, but no depression of GFR. Inhibition of both Cox isoforms by indomethacin caused transient sodium retention and a decline in GFR. Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1. (+info)

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. (7/2198)

The mature form of the cathepsin B-like protease of Leishmania major (LmajcatB) is a 243 amino acid protein belonging to the papain family of cysteine proteases and is 54% identical to human-liver cathepsin B. Despite the high identity and structural similarity with cathepsin B, LmajcatB does not readily hydrolyse benzyloxycarbonyl-Arg-Arg-7-amino-4-methyl coumarin (Z-Arg-Arg-AMC), which is cleaved by cathepsin B enzymes. It does, however, hydrolyse Z-Phe-Arg-AMC, a substrate typically cleaved by cathepsin L and B enzymes. Based upon computer generated protein models of LmajcatB and mammalian cathepsin B, it was predicted that this variation in substrate specificity was attributed to Gly234 at the S2 subsite of LmajcatB, which forms a larger, more hydrophobic pocket compared with mammalian cathepsin B. To test this hypothesis, recombinant LmajcatB was expressed in the Pichia pastoris yeast expression system. The quality of the recombinant enzyme was confirmed by kinetic characterization, N-terminal sequencing, and Western blot analysis. Alteration of Gly234 to Glu, which is found at the corresponding site in mammalian cathepsin B, increased recombinant LmajcatB (rLmajcatB) activity toward Z-Arg-Arg-AMC 8-fold over the wild-type recombinant enzyme (kcat/Km=3740+/-413 M-1.s-1 versus 472+/-72.4 M-1.s-1). The results of inhibition assays of rLmajcatB with an inhibitor of cathepsin L enzymes, K11002 (morpholine urea-Phe-homoPhe-vinylsulphonylphenyl, kinact/Ki=208200+/-36000 M-1. s-1), and a cathepsin B specific inhibitor, CA074 [N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-l-isoleucyl-l- prolin e, kinact/Ki=199200+/-32900 M-1.s-1], support the findings that this protozoan protease has the P2 specificity of cathepsin L-like enzymes while retaining structural homology to mammalian cathepsin B. (+info)

Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats. (8/2198)

Male Sprague-Dawley rats received four consecutive intraperitoneal (i.p.) doses of five kinds of methylsulfonyl (MeSO2) metabolites of tetra- and pentachlorinated biphenyls (tetra- and pentaCBs) to determine their effects on thyroid hormone levels. The five MeSO2 metabolites, which were the major MeSO2-PCBs detected in human milk, liver and adipose tissue were 3-MeSO2-2,2',4',5-tetraCB (3-MeSO2-CB49),3-MeSO2-2,3',4',5-tetraCB (3-MeSO2-CB70), 3-MeSO2-2,2',3',4',5-pentaCB (3-MeSO2-CB87), 3-MeSO2-2,2',4',5,5'-pentaCB (3-MeSO2-CB101), and 4-MeSO2-2,2',4',5,5'-pentaCB (4-MeSO2-CB101). All five tested MeSO2 metabolites (20 mumol/kg once daily for 4 days) reduced serum total thyroxine levels 16-40% on days 2, 3, 4, and 7 (after the last dosage). The total triiodothyronine level was reduced 37% by treatment with 3-MeSO2-CB49 at day 7, but was increased 35% and 38% by 3-MeSO2-CB70 and 4-MeSO2-CB101 at days 3 and 4, respectively. The reductions in thyroid hormone levels led to an increase in thyroid stimulating hormone (TSH) levels by 3-MeSO2-CB49, 3-MeSO2-CB87 and 3-MeSO2-CB101. A 30% increase in thyroid weight was produced by 3-MeSO2-CB101 treatment. Thus, it is likely that all five tested MeSO2 metabolites could influence thyroid hormone metabolism. The results show that the tested 3- and 4-MeSO2 metabolites of tetra- and pentaCBs reduce thyroid hormone levels in rats, suggesting that the metabolites may act as endocrine-disrupters. (+info)

Precursors to such polymers are the sulfones bisphenol S and 4,4′-dichlorodiphenyl sulfone. Examples of sulfones in ... Sulfones have been prepared by nucleophilic displacement of halides by sulfinates: ArSO 2 Na + Ar ′ Cl ⟶ Ar ( Ar ′ ) SO 2 + ... Sulfones are prepared under conditions used for Friedel-Crafts reactions using sources of RSO+ 2 derived from sulfonyl halides ... Sulfones are typically prepared by organic oxidation of thioethers, often referred to as sulfides. Sulfoxides are intermediates ...

https://en.wikipedia.org/wiki/Sulfone

... is also a metabolite of armodafinil, the (R)-(-)-enantiomer of modafinil, as oxidation to the sulfone removes ... Modafinil sulfone has been described as inactive, and similarly to modafinil acid, does not appear to contribute to the ... Modafinil sulfone (code name CRL-41056) is an achiral, oxidized metabolite of modafinil, a wakefulness-promoting agent. It is ... Chatterjie N, Stables JP, Wang H, Alexander GJ (2004). "Anti-narcoleptic agent modafinil and its sulfone: a novel facile ...

https://en.wikipedia.org/wiki/Modafinil_sulfone

... (or mustard sulfone) is an oxidation product of mustard gas. It has the formula (ClCH2CH2)2SO2. ... When treated with sodium carbonate, a weaker base, bis-(hydroxyethyl)sulfone is the major product formed. In comparison the ... "Conformations Of Mustard Sulfoxide And Mustard Sulfone". Phosphorus, Sulfur, and Silicon and the Related Elements. 142 (1): 149 ...

https://en.wikipedia.org/wiki/Dichlorodiethyl_sulfone

... phenyl vinyl sulfone, methyl vinyl sulfone, and ethyl vinyl sulfone. The sulfone makes the vinyl group electrophilic, allowing ... Vinyl sulfone has uses as a molluscicide pesticide. Phenyl vinyl sulfone has been applied to ruthenium chemistry as part of ... In organic chemistry, a vinyl sulfone is a functional group consisting of a vinyl group bonded to a sulfone group. Specific ... Vinyl sulfone has applications to protein purification, especially when linked with mercaptoethanol. Leonard, Edward C. (1970 ...

https://en.wikipedia.org/wiki/Vinyl_sulfone

... is a sulfone containing two 2-bromo-ethyl substituents. Dibromodiethyl sulfone is produced from ...

https://en.wikipedia.org/wiki/Dibromodiethyl_sulfone

... is an organosulfur compound with the formula (C6H5)2SO2. It is a white solid that is soluble in organic ...

https://en.wikipedia.org/wiki/Diphenyl_sulfone

... are reactive dyes comprising a vinyl sulfone group as reactive group (a fiber-bonding site of the reactive ... Formation of the vinyl sulfone group by alkaline elimination. R= alkyl or aryl radical, X=-OSO3H, -Cl The vinyl sulfone ... The vinyl sulfone parabase ester can be used as a diazo component in the preparation of azo dyes. A further possibility is the ... If the vinyl sulfone group is introduced via a primary or secondary aliphatic amine, this is performed again by condensation ...

https://en.wikipedia.org/wiki/Vinyl_sulfone_dyes

4,4′-Dichlorodiphenyl sulfone (DCDPS) is an organic compound with the formula (ClC6H4)2SO2. Classified as a sulfone, this white ... "Synthesis of aryl sulfones". The Journal of Organic Chemistry. 32 (9): 2931-2933. doi:10.1021/jo01284a075. Udel Polysulfone ... dichlorodiphenyl sulphone" (PDF). Acta Crystallographica. 13 (1): 1-9. doi:10.1107/S0365110X60000017. Parker, David; Bussink, ...

https://en.wikipedia.org/wiki/4,4'-Dichlorodiphenyl_sulfone

In these oxidations, care is required to avoid over oxidation to form the sulfone. For example, dimethyl sulfide is oxidized to ... Roy K (2002). "Sulfones and Sulfoxides". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/ ... dimethyl sulfoxide and then further to dimethyl sulfone. Unsymmetrical sulfides are prochiral, thus their oxidation gives ...

https://en.wikipedia.org/wiki/Sulfoxide

The Ramberg-Bäcklund reaction is an organic reaction converting an α-halo sulfone into an alkene in presence of a base with ... 8, p. 212 ^ Evans, P.; Johnson, P.; Taylor, R. J. K. (April 2006). "The Epoxy-Ramberg-Bäcklund Reaction (ERBR): A Sulfone-Based ... The original procedure involved halogenation of a sulfide, followed by oxidation to the sulfone. Recently, the preferred method ... doi:10.1016/S0040-4020(01)01224-8. ^ Paquette, Leo A.; Philips, J. Christopher; Wingard, Robert E. (1971). "α-Halo sulfones. ...

https://en.wikipedia.org/wiki/Ramberg–Bäcklund_reaction

It is an intramolecular nucleophilic aromatic substitution of the type: where X in the arene compound can be a sulfone, a ... This reaction is exemplified by the conversion of an aryl sulfone into a sulfinic acid by action of n-butyllithium: This ... Truce, William E.; Ray, William J.; Norman, Oscar L.; Eickemeyer, Daniel B. (July 1958). "Rearrangements of Aryl Sulfones. I. ... The Metalation and Rearrangement of Mesityl Phenyl Sulfone". Journal of the American Chemical Society. 80 (14): 3625-3629. doi: ...

https://en.wikipedia.org/wiki/Smiles_rearrangement

It is also known by several other names including methyl sulfone and dimethyl sulfone (DMSO2). This colorless solid features ... Gaylord Chemical Company, LLC "Dimethyl sulfone". "Dimethyl sulfone". pubchem.ncbi.nlm.nih.gov. "Various Names for MSM" (PDF). ... 751, dimethyl sulfone 1 BT No. A6409. Northbrook, Illinois: Industrial BIO-TEST Laboratories, Inc. Kababick JP (1999). Ocular ... This group [Afipia] is commonly found in aquatic environments and is known to use dimethyl sulfone (DMSO2) as a sole carbon ...

https://en.wikipedia.org/wiki/Methylsulfonylmethane

Application to the Synthesis of Sulfones". Organic Letters. 1 (8): 1177-1180. doi:10.1021/ol990170k. v t e (Articles without ... as well as oxidation of thiols to sulfones. It is named for Franklin A. Davis. Davis, Franklin A.; Vishwakarma, Lal C.; ...

https://en.wikipedia.org/wiki/Davis_reagent

... , or butadiene sulfone is a cyclic organic chemical with a sulfone functional group. It is a white, odorless, ... An analogous procedure gives the isoprene-derived sulfone. The compound is unaffected by acids. It can even be recrystallized ... 2015). "Butadiene sulfone as 'volatile', recyclable dipolar, aprotic solvent for conducting substitution and cycloaddition ... ISBN 978-3-13-208104-8. Robert L. Frank, Raymond P. Seven (1949). "Isoprene Cyclic Sulfone". Organic Syntheses. 29: 59. doi: ...

https://en.wikipedia.org/wiki/Sulfolene

Robert L. Frank, Raymond P. Seven (1949). "Isoprene Cyclic Sulfone". Organic Syntheses. 29: 59. doi:10.15227/orgsyn.029.0059. ...

https://en.wikipedia.org/wiki/Piperylene

It is of the sulfone class. Dapsone was first studied as an antibiotic in 1937. Its use for leprosy began in 1945. It is on the ... 2001). "Dapsone and sulfones in dermatology: overview and update". Journal of the American Academy of Dermatology. 45 (3): 420- ... The sulfone syndrome revisited". Arch Dermatol. 117 (1): 38-9. doi:10.1001/archderm.1981.01650010044023. PMID 6450569. Kromann ... Dapsone, also known as 4,4'-sulfonyldianiline (SDA) or diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in ...

https://en.wikipedia.org/wiki/Dapsone

It can be oxidised to a sulfoxide with calcium hypochlorite or sodium periodate, or continuing to a sulfone. It can react with ... 2008). "Product Subclass 2: Cyclic Dialkyl Sulfones and Derivatives". Category 5, Compounds with One Saturated Carbon ...

https://en.wikipedia.org/wiki/1,4-Oxathiane

At first, a specific sulfone is formed in 22 steps of common chemistry. This sulfone is coupled with a straightforward epoxide ... This coupling reaction is most efficient when the sulfone is transformed into a dianion with n-butyllithium, followed by ... Hereby, a diastereomeric mixture of sulfones is formed. After reductive desulfurization and methylation, the formation of a ...

https://en.wikipedia.org/wiki/Debromoaplysiatoxin

"Sulfones expand the reach of radical cross-couplings , January 8, 2018 Issue - Vol. 96 Issue 2 , Chemical & Engineering News". ...

https://en.wikipedia.org/wiki/Cathleen_Crudden

Sulfoxides and sulfones are thioethers with one and two oxygen atoms attached to the sulfur atom, respectively. The simplest ... sulfoxide, dimethyl sulfoxide, is a common solvent; a common sulfone is sulfolane. Sulfonic acids are used in many detergents. ...

https://en.wikipedia.org/wiki/Sulfur

ISBN 978-3-527-32669-3. Wozel, Gottfried (1989). "The Story of Sulfones in Tropical Medicine and Dermatology". International ...

https://en.wikipedia.org/wiki/History_of_leprosy

For example, it converts thioethers into sulfoxides and sulfones. In the European Union, sodium perborate, like most borates, ...

https://en.wikipedia.org/wiki/Sodium_perborate

Stork, G; Borowitz, IJ (1962). "Four-membered Sulfones from Enamines and Aliphatic Sulfonyl Halides". J. Am. Chem. Soc. 84 (2 ... in a catalytic asymmetric synthesis of β-sulfones (four-membered ring sulfonate esters). Sulfene can also undergo insertion ...

https://en.wikipedia.org/wiki/Sulfene

"Current Data on Promin Therapy; reprinted in The Star October-December 2003" (PDF). Wozel G (1989). "The story of sulfones in ... Promin, or sodium glucosulfone is a sulfone drug that was investigated for the treatment of malaria, tuberculosis and leprosy. ... The medical evaluation of sulfones was inspired by the discovery of the unprecedented value of synthetic compounds such as ... Promin and other sulfones can also not be used as substitutes for dapsone when intolerance develops, as this is a general ...

https://en.wikipedia.org/wiki/Promin

It has also been used in organic chemistry as electrophile to transform sulfones into aldehydes. MNP is also an efficient ... Rodrigo, Eduardo; Alonso, Inés; Cid, M. Belén (2018-09-21). "A Protocol To Transform Sulfones into Nitrones and Aldehydes". ...

https://en.wikipedia.org/wiki/2-Methyl-2-nitrosopropane

DMSO is metabolized by disproportionation to dimethyl sulfide and dimethyl sulfone. It is subject to renal and pulmonary ... Chakrabarti R, Schutt CE (August 2001). "The enhancement of PCR amplification by low molecular-weight sulfones". Gene. 274 (1-2 ... Roy, Kathrin-Maria (15 June 2000), "Sulfones and Sulfoxides", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim, Germany ... SO2 and sulfate Dimethyl sulfone, commonly known as methylsulfonylmethane (MSM), a related chemical often marketed as a dietary ...

https://en.wikipedia.org/wiki/Dimethyl_sulfoxide

The chloride salt of FePc, FePcCl, has also been used to help catalyse the synthesis of sulfones from sulfonylhydrazones. ... 1 June 2016). "Iron(III) phthalocyanine-chloride-catalyzed synthesis of sulfones from sulfonylhydrazones". Tetrahedron Letters ...

https://en.wikipedia.org/wiki/Iron(II)_phthalocyanine

... 1,1-dioxides are sulfones, the parent being C3H4SO2. They are more stable than the parent thietes. Substituted thiete-1, ...

https://en.wikipedia.org/wiki/Thiete

One of the drawbacks of HF5 is the limited choice of membrane materials; only polyether sulfone (PES) membranes are available. ...

https://en.wikipedia.org/wiki/Field_flow_fractionation

Allen, Joshua L.; Boyle, Paul D.; Henderson, Wesley A. (2011-05-15). "Lithium difluoro(oxalato)borate tetramethylene sulfone ...

https://en.wikipedia.org/wiki/Borate_oxalate

Aldicarb sulfone. Find out what is in your tap water ... EWGs Tap Water Database Aldicarb sulfone results for Genoa ... Aldicarb sulfone. Genoa City Waterworks. Aldicarb sulfone is a groundwater contaminant and a neurotoxic metabolite of the ...

https://www.ewg.org/tapwater/system-contaminant.php?pws=WI2650058&contamcode=2044

... View/. Open. Full Text (‎711.8 ... 1975)‎. Bacteriological status (‎point prevalence)‎ of lepromatous outpatients under sulfone treatment. Bulletin of the World ...

https://extranet.who.int/iris/restricted/handle/10665/260808

... polyphenylene sulphone can provide a continuous service temperature of up to 300C, a compressive strength of 22 ksi, and a ... Ceramer(reg) polyphenylene sulphone can provide a continuous service temperature of up to 300C, a compressive strength of 22 ...

https://www.designnews.com/polyphenylene-sulphone

1963)‎. Study on the joint action of Diamino-Diphenyl Sulfone (‎DDS)‎ and Pyrimethamine against Plasmodium gallinaceum and ... Study on the joint action of Diamino-Diphenyl Sulfone (‎DDS)‎ and Pyrimethamine against Plasmodium gallinaceum and Plasmodium ...

https://apps.who.int/iris/handle/10665/65092

... ...

https://www.ncbi.nlm.nih.gov/Structure/pdb/4WX6

US-2998454-A chemical patent summary.

https://pubchem.ncbi.nlm.nih.gov/patent/US-2998454-A

... arylene ether sulfone) (PSU) ionomers containing disulfonated aryl-SO2-aryl and tetrasulfonated aryl-SO2-aryl-aryl-SO2-aryl ... Sulfonated poly(arylene ether sulfone) ionomers. containing di- and tetrasulfonated arylene sulfone segments E. P. Jutemar, S. ... Sulfonated poly(arylene ether sulfone) ionomers containing di- and tetrasulfonated arylene sulfone segments† ... Poly(arylene ether sulfone) (PSU) ionomers. containing disulfonated aryl-SO2-aryl and tetrasulfonated aryl-SO2-aryl-aryl-SO2- ...

https://pubs.rsc.org/en/Content/ArticleLanding/2011/PY/C0PY00290A

Share and Growth Outlook The Sulfone Polymers market is expected to register fluctuating growth trends in the long term, while ... Sulfone Polymers supply chain analysis Sulfone Polymers trade analysis, Sulfone Polymers market price analysis, Sulfone ... 2. GLOBAL SULFONE POLYMERS MARKET REVIEW, 2022. 2.1 Sulfone Polymers Industry Overview. 2.2 Research Methodology. 3. SULFONE ... SULFONE POLYMERS MARKET STRUCTURE AND COMPETITIVE LANDSCAPE. 12.1 Key Companies in Sulfone Polymers Business. 12.2 Sulfone ...

https://marketpublishers.com/report/chemicals_petrochemicals/2023-sulfone-polymers-market-outlook-report-market-size-market-split-market-shares-data-insights-trends-opportunities-companies-impact-of-inflation.html

China 4-Bromo phenyl methyl sulfone Suppliers ,offers quality China 4-Bromo phenyl methyl sulfone. ... TIMTEC-BB SBB006294;P-METHYL BENZENESULFOBROMIDE;4-BROMOPHENYL METHYL SULPHONE;1-bromo-4-(methylsulphonyl)benzene;4-Bromo ... Home > Offer to Sell > Machinery and Equipment > 4-Bromo phenyl methyl sulfone ...

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Divanillyl sulfone (DS), a novel structural derivative of 4,4′-dihydroxydibenzyl sulfoxide from a traditional Chinese medicine ... From: Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain ...

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The signs and symptoms of methemoglobinemia listed in Table 3 can be roughly correlated with the percentage of total hemoglobin in the oxidized form (see "Clinical Assessment-Laboratory Tests"). Unfortunately, because methemoglobin (MetHb) is generally expressed as a percent of total hemoglobin, levels may not correspond with symptoms in some patients. For example, a patient with a MetHb level of 20% and total hemoglobin of 15 grams per deciliter (g/dL) still has 12 g/dL of functioning hemoglobin, whereas a patient with a MetHb level of 20% and total hemoglobin of 8 g/dL has only 6.4 g/dL of functioning hemoglobin. Anemia, acidosis, respiratory compromise, cardiovascular disease, sepsis or the presence of other abnormal hemoglobin species (i.e. carboxyhemoglobin, sulfhemoglobin, sickle hemoglobin (HbS) may make patients more symptomatic than expected for a given MetHb level [Wright et al. 1999; Ash-Bernal et al. 2004; Skold et al. 2011].. Due to the large excess capacity of the blood to carry ...

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Dimethyl Sulfone a.k.a methylsulfonylmethane (MSM) is a chemical compound which has been steadily gaining in popularity over the last few years. (drjockers.com)
In this article we will discuss Dimethyl Sulfone and its potential health benefits for the body and help you decide if it is something you need to add into your wellness stack. (drjockers.com)
What is Dimethyl Sulfone? (drjockers.com)
Dimethyl Sulfone is an organosulfur compound (or to put it simply, an organic sulfur) that comes in the form of many names like methylsulfonylmethane (MSM), DMSO2, and methyl sulfone among others. (drjockers.com)
Dimethyl sulfone is an oxidation product of dimethyl sulfoxide (DMSO) and provides a source of sulfur, used for the creation of two amino acids - methionine and cysteine. (drjockers.com)
In supplement form, dimethyl sulfone is an odorless, white, crystalline and water-soluble compound. (drjockers.com)
Dimethyl Sulfone provides sulfur to the body, which as explained already, is a fundamentally important nutrient for cellular health and function. (drjockers.com)
Researched benefits of dimethyl sulfone vary widely and include everything from anti-inflammatory to improvements in athletic performance ( 5 ). (drjockers.com)

In some organisms, several different mechanisms failure of sulfamethoxazole as well as dapsone, a sulfone of resistance have been identified in different strains. (cdc.gov)
Dapsone belongs to a class of drugs known as sulfones. (alto-ziadny.com)
Dapsone is a synthetic sulphone, similar to the sulphonamide drugs, targeting dihydropteroate synthase, a key enzyme in bacteria. (alto-ziadny.com)
Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. (alto-ziadny.com)
Dapsone: La dapsone est un antibactérien qui appartient à l'une des principales familles antibiotiques, les sulfones. (alto-ziadny.com)

Poly(arylene ether sulfone) (PSU) ionomers containing disulfonated aryl-SO 2 -aryl and tetrasulfonated aryl-SO 2 -aryl-aryl-SO 2 -aryl segments, respectively, were synthesized and studied to establish their structure-property relationships as proton -exchange membranes. (rsc.org)
Zhao, L & Mohanty, DK 1994, ' Synthesis and Characterization of Poly(aryl ether-sulfone)-Poly(tetrahydrofuran) (A-B)N Block Copolymer ', Journal of Material Chemistry , vol. 4, no. 4, pp. 623. (cmich.edu)
Here, we have characterised the blending of poly (ether sulfone) (PES) and poly (ethylene naphthalate) (PEN), which have dissimilar repeat units. (elsevier.com)

An eco-friendly visible light-induced approach for the synthesis of vinyl sulfones from the reaction of nitroolefins with sulfinic acid under photocatalyst free conditions was developed. (sioc-journal.cn)
Visible-Light Induced Sulfonylation of Nitroolefins for the Synthesis of Vinyl Sulfones under Photocatalyst Free Conditions[J]. Chinese Journal of Organic Chemistry , 2020, 40(12): 4267-4273. (sioc-journal.cn)
An Efficient and Novel Method for the Synthesis of Aromatic Sulfones under Solvent-Free condition. (ac.ir)

The Sulfone Polymers market is expected to register fluctuating growth trends in the long term, while inflation and supply chain concerns are expected to continue in 2023. (marketpublishers.com)
Shifting consumer preferences in a projected economic downturn scenario, amendments to industrial policies to align with growing environmental concerns, huge fluctuations in raw material costs triggered by prevailing geo-political tensions, and expected economic turbulences are noted as key challenges to be addressed by the Sulfone Polymers industry players during the short and medium term forecast. (marketpublishers.com)
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And these membranes are made of sulfone polymers , a technology in which Solvay has deep expertise. (solvay.com)
Haemodialysis membranes manufactured with sulfone polymers from Solvay have treated tens of millions of patients, and Solvay is the innovation leader in this field," explains Jesal Chopra , Vice President - Healthcare, Environment, Consumer, & Construction, Specialty Polymers. (solvay.com)

4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor. (cdc.gov)

Allylic nitro compounds undergo denitro-sulfonylation catalyzed by Pd(PPh 3 ) 4 or Pd(PPh 3 ) 4 +NaNO 2 with PhSO 2 Na·2H 2 O to afford allylic sulfones regioselectively. (elsevier.com)

Medications used to treat chronic urticaria include antihistamines (first- and second-generation), anti-inflammatory agents, and sulfones. (medscape.com)

Based on the study executed by Chilworth Technology in 1997, it can be concluded that for diphenyl sulphone no auto ignition up to temperature of 475°C is seen, so this compound is very stable and resistant to auto flammability. (europa.eu)

The method is based on the reaction of the respective nitroalkane with α-amido sulfones effected by CsOH·H2O base in toluene as solvent and in the presence of cinchone-derived ammonium catalysts. (uzh.ch)

This procedure allowed the introduction of two sulfonic acid units on electron-deficient aryl rings in ortho positions to each sulfone bridge of the PSUs. (rsc.org)
It has been shown that gw1516 and gw0742 are best monitored as the sulfone metabolites which are detectable in urine using lc-ms/ms based procedure up to 40 and. (workshoppingtheworkshop.com)

criteria included study populations composed entirely of PCP patients and mutation or treatment outcome results for Failure of sulfa or sulfone (sulfa) prophylaxis against all patients, regardless of exposure status. (cdc.gov)

Aksharchem (India) Ltd. has stopped production of Vinyl Sulphone (VS) plant at village Indrad, district Mehsana, Gujarat as it is due for maintenance since last maintenance was taken five years before. (indianchemicalnews.com)

Ceramer(reg) polyphenylene sulphone can provide a continuous service temperature of up to 300C, a compressive strength of 22 ksi, and a glass transition temperature of nearly 360C. (designnews.com)

1975)‎. Bacteriological status (‎point prevalence)‎ of lepromatous outpatients under sulfone treatment. (who.int)

An auto-flammability test is executed by Chilworth Technology on diphenyl sulphone on request of Victrex Manufacturing Ltd. This study is according to ASTM E659-78. (europa.eu)

According to a detailed report by Fact.MR, a market research and competitive intelligence provider, the market for 4,4-dichlorodiphenly sulfone accounts for an approximate valuation of US$ 419. (theguardiantribune.com)

Cytotoxic effects of fipronil and fipronil sulfone were examined using the adenylate kinase and the trypan blue exclusion assays in HepG2 cells and human hepatocytes. (cdc.gov)
For fipronil sulfone, cytotoxic effects increased throughout the dose range. (cdc.gov)
However, fipronil sulfone induced cytotoxic effects at lower doses. (cdc.gov)

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Citation: Shelby, M.D., Gutierrez-Espeleta, G.A., Generoso, W.M., and McFee, A.F. Mouse dominant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone. (nih.gov)
Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p'-DDE in human tissues. (nih.gov)
An oxidant-free dehydrogenative sulfonylation of α-methyl-styrene derivatives was developed for the construction of allylic sulfones by using eosin Y as a photosensitizer in conjunction with a cobaloxime catalyst. (rsc.org)
Dimethyl sulfone is obtained by oxidizing methyl sulfone using nitric acid as oxidation. (chemicalbook.com)
Methyl sulfone was oxidized at 140-145 ℃ by nitric oxide. (chemicalbook.com)

Compared with dimethyl sulfoxide, diphenyl sulfone is chemically and thermally stable. (zhishangchemical.com)
Sulindac undergoes two major biotransformations of its sulfoxide moiety: oxidation to the inactive sulfone and reduction to the pharmacologically active sulfide. (nih.gov)
Three corresponding O-demethylated metabolites of the sulfide, sulfoxide and sulfone moieties were also identified in the urine, as were two additional metabolites presumably resulting from cleavage of the O-methylphosphoric ester group and subsequent methylation and sulfoxidation steps. (inchem.org)
Hearn, 40, tested positive for 19-norandrosterone (19-NA), the main metabolite of nandrolone (19-nortestosterone) and other 19-norsteroids, clomiphene, trenbolone metabolite epitrenbolone, and GW1516 (GW501516) metabolites GW1516 sulfone and GW1516 sulfoxide, as the result of an in-competition drug test conducted at the 2022 Masters Weightlifting National Championship on April 24, 2022. (usada.org)

For the first time, the synthesis of fluorine-containing organic compounds involved in various difluoromethyl heteroaryl sulfones in the past decade is reviewed from the perspective of reaction types and their application studies. (sioc-journal.cn)
Diphenyl sulfone is used in organic synthesis as plasticizer and acaricide. (zhishangchemical.com)
DABSO-based, three-component, one-pot sulfone synthesis. (ox.ac.uk)
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. (sigmaaldrich.com)

In Agrama Laboratory we analyze pesticides in all types of foods, always with the latest techniques and newest methods, for more than 20 years, including fipronil, fipronil desulfonil and fipronil sulfone, these last metabolites of the previous one, which can also be present in the food by the degradation of fipronil. (laboratorioagrama.com)

4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor. (cdc.gov)

Divinyl sulfone is a clear colorless liquid. (nih.gov)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Divinyl sulfone (77-77-0). (nih.gov)

The current study strives to address these issues by investigating the interrelationships between structures, properties and processing methods in quaternary ammonium functionalized poly(arylene ether sulfone) ionomer AEMs. (unl.edu)
A series of cardo poly(ether sulfone imide)s (PESI-C) containing bulky phthalide groups were prepared via aromatic nucleophilic substitution reaction of phenolphthalein with 4,40-difluorodiphenyl sulfone and 4,40-bis(4-fluorophthalimido) diphenyl ether (BFPI). (polymer.cn)
Sulfonated poly(arylene ether sulfone) (SPAES-F series) membranes, which are partially fluorinated multiblock polymers containing Bisphenol 6F (6F-BPA), are synthesized. (elsevier.com)
Louette, P , Bodino, F & Pireaux, J-J 2005, Poly(p-phenylene ether sulfone) (PES) XPS reference core level and energy loss spectra . (unamur.be)
Students and researchers will synthesize and characterize hybrid poly(arylene ether sulfone) (PAES) semi-synthetic materials using different glycan chemistries. (nsf.gov)
This technology relates to anion exchange membranes with enhanced stability to high pH environments including poly(arylene sulfone) or poly(arylene ketone) with anion exchange groups. (rpi.edu)

Following absorption, sulindac undergoes two major biotransformations - reversible reduction to the sulfide metabolite, and irreversible oxidation to the sulfone metabolite. (nih.gov)

Hence, the present study was undertaken to analyze the effect of sulindac and its irreversible oxidized derivative, sulindac sulfone (exisulind), in three human HCC cell lines. (aacrjournals.org)

Le traîtement du paludisme chez l' homme par une dose unique de Diamino-Diphenyl-Sulfone (‎DDS)‎ seule ou associée à la pyriméthamine. (who.int)
What is Diphenyl Sulfone? (zhishangchemical.com)
Under certain conditions, the sulfuric acid solution reacts with benzene to form diphenyl sulfone. (zhishangchemical.com)
Diphenyl sulfone is used as intermediate of medicine and pesticide. (zhishangchemical.com)
If you want to buy diphenyl sulfone, pls contact us to get a free quote. (zhishangchemical.com)

Cytotoxic effects of fipronil and fipronil sulfone were examined using the adenylate kinase and the trypan blue exclusion assays in HepG2 cells and human hepatocytes. (cdc.gov)
For fipronil sulfone, cytotoxic effects increased throughout the dose range. (cdc.gov)
However, fipronil sulfone induced cytotoxic effects at lower doses. (cdc.gov)

Difluoromethyl heteroaryl sulfones, represented by 2-PySO 2 CF 2 H (Hu reagent), have been developed recently as difluoromethylation reagents, and widely recognized by synthetic chemists for their ease of preparation, good functional group tolerance and universal applicability to a wide range of carbonyl compounds. (sioc-journal.cn)
Progress of Difluoromethyl Heteroaryl Sulfones as Difluoroalkylation Reagents[J]. Chinese Journal of Organic Chemistry , 2019, 39(10): 2726-2734. (sioc-journal.cn)

Conjugates prepared with bis-sulfone reagents benefits from reduced heterogeneity and enhanced stability. (dcbiosci.com)

The sulfones may cause any of the side effects listed above for sulfonamides. (mhmedical.com)

Micro-magnetic silica-based particles chemically immobilizing diethyl sulfone functional groups were pseudo-stationarily placed inside a knotted tube reaction flow-coil under the influence of an external magnetic field from two sandwiched magnets. (rsc.org)

Some further slight oxidation of the same side chain to form the corresponding sulfone was also observed. (inchem.org)
The use of hydrogen peroxide for the oxidation of aliphatic thiols and thioethers to sulfonyl chlorides, sulfoxides and sulfones is an alternative to chlorine oxidation. (cabb-chemicals.com)

Chapman, CJ , Frost, CG & Mahon, MF 2006, ' Structure and reactivity of new phosphine ligands containing the hemi-labile sulfone moiety ', Dalton Transactions , vol. 2006, no. 18, pp. 2251-2262. (bath.ac.uk)
Bis-sulfone-PEG4-DBCO is a bis-alkylating labelling reagent that enables site-specific incorporation of DBCO moiety onto antibodies to form well-defined conjugates. (dcbiosci.com)

β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic " by Elizabeth A. Rodkey, David C. Mcleod et al. (csuohio.edu)

Mozharov's urine tested positive for GW1516 sulfone, a hormone and metabolic modulator. (yahoo.com)

Now, you can bond to polycarbonate (PC), polyphenyl sulfone (PPSU), polyether imide (PEI) and acrylic-PVC among others. (3m.com)
Dishwasher and microwave safe BPA-Free Bottles are made from Polyether Sulphone (PES) - a BPA Free material with a natural honey-colored tint. (selfexpressions.com)

Dimethyl sulfone is a high tempereture solvent for many inorganic and organic substances,it is used as antiinflammatory, antiproliferative, antiparasitic. (chemicalbook.com)

The best results in the treatment of leprosy have been achived with a sulphone-oil suspension and the dose to be given to children is adjusted to their body weigh. (nih.gov)

The emission lifetimes for the three complexes containing sulfone substituents are an order of magnitude longer (2.33 to 3.36 μs) than the remaining complexes (0.224 to 0.528 μs). (unibas.ch)
Diphenylsulfone is a sulfone compound with two S-phenyl substituents. (zhishangchemical.com)

Dimethyl sulfone is a good penetrant in medicines production. (chemicalbook.com)

New heterofunctional phosphine ligands have been synthesised, incorporating the substitutionally labile sulfone and sulfonamide moieties as chelating groups, which display activity in the palladium-catalysed Suzuki and amination cross-coupling reactions. (bath.ac.uk)

Studies on the toxicity and the action of Diamino-Diphenyl Sulphone (‎DDS)‎ in Avian and Simian Malaria. (who.int)
1961)‎. Studies on the toxicity and the action of Diamino-Diphenyl Sulphone (‎DDS)‎ in Avian and Simian Malaria. (who.int)

Our functional groups are tertiary -butylester, vinyl sulfone and FMOC-protecting group on nitrogen. (chemicalforums.com)

Solvay alone has projected the increase of its global sulfone polymer production by 35% in the next 5 years, with significant investments in Asia and USA. (wordpress.com)

A series of [Ir(C^N)2(bpy)][PF6] complexes in which the cyclometallating ligands contain fluoro, sulfane or sulfone groups is reported. (unibas.ch)

Hemolysis of red cells due to sulfone. (nih.gov)

Chemicals and Drugs6

Phenomena and Processes4

Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. (1/2198)

Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). (2/2198)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (3/2198)

Implication of endogenous nitric oxide in gastric mucosal protective effect of T-593, a novel anti-ulcer agent, in rats. (4/2198)

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. (5/2198)

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. (6/2198)

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. (7/2198)

Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats. (8/2198)

Sulfones

Penicillanic Acid

Dapsone

Organic Chemistry Phenomena

Sulfoxides

Molecular Structure

Sulfonamides

Stereoisomerism

beta-Lactamases

Structure-Activity Relationship

Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. (1/2198)

Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). (2/2198)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (3/2198)

Implication of endogenous nitric oxide in gastric mucosal protective effect of T-593, a novel anti-ulcer agent, in rats. (4/2198)

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. (5/2198)

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. (6/2198)

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. (7/2198)

Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats. (8/2198)

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