A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A group of compounds that contain the structure SO2NH2.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Compounds that contain two halogenated benzene rings linked via an OXYGEN atom. Many polybrominated diphenyl ethers are used as FLAME RETARDANTS.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.
Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Exclusive legal rights or privileges applied to inventions, plants, etc.
A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.
ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Analogs or derivatives of prostaglandin A that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGA.
Materials applied to fabrics, bedding, furniture, plastics, etc. to retard their burning; many may leach out and cause allergies or other harm.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Any enterprise centered on the processing, assembly, production, or marketing of a line of products, services, commodities, or merchandise, in a particular field often named after its principal product. Examples include the automobile, fishing, music, publishing, insurance, and textile industries.
Organizations established by endowments with provision for future maintenance.
The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. (1/2198)

Wild-type (wt) p53 frequently induces apoptosis when expressed in tumor cells whereas mutant p53 acts as an oncoprotein and consequently, stimulates cell proliferation. We report here exceptions to that rule. p53 conformational mutant 175H and DNA contact mutant 273H provoke apoptosis in human p53-deficient Hep3B hepatoma cells with delayed kinetics relative to wt p53. Similarly, c-Myc strongly stimulates apoptosis in these cells. In contrast, viral oncoproteins E1A and E7, and the cellular oncoprotein MDM-2, fail to elicit cytocidal responses. Efficient apoptotic cell death by mutant p53 requires oligomerization as 175H and 273H with deletions between amino acid residues 326 and 347 of the oligomerization domain are nontoxic. Apoptosis by mutant or wt p53 was significantly inhibited by the serine protease inhibitor AEBSF but not by the inactive analog AEBSA. Together, these results suggest that a wt p53-independent control mechanism is operational in Hep3B cells that eliminates cells upon sensing illegitimate proliferation signals originating from certain oncoproteins, including mutant p53 and Myc. We suggest that some tumor cell types lack p53 altogether because they tolerate neither wild-type nor mutant forms of the protein.  (+info)

Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). (2/2198)

1. Adenosine influences the vectorial transport of Na+ and HCO3- across kidney epithelial cells. However, its action on effector proteins, such as the Na+-H+ exchanger NHE3, an epithelial brush border isoform of the Na+-H+ exchanger (NHE) gene family, is not yet defined. 2. The present study was conducted in Xenopus laevis distal nephron A6 epithelia which express both an apical adenosine receptor of the A1 type (coupled to protein kinase C (PKC)) and a basolateral receptor of the A2 type (coupled to protein kinase A (PKA)). The untransfected A6 cell line expresses a single NHE type (XNHE) which is restricted to the basolateral membrane and which is activated by PKA. 3. A6 cell lines were generated which express exogenous rat NHE3. Measurements of side-specific pHi recovery from acid loads in the presence of HOE694 (an inhibitor with differential potency towards individual NHE isoforms) detected an apical resistant Na+-H+ exchange only in transfected cell lines. The sensitivity of the basolateral NHE to HOE694 was unchanged, suggesting that exogenous NHE3 was restricted to the apical membrane. 4. Stimulation of the apical A1 receptor with N 6-cyclopentyladenosine (CPA) inhibited both apical NHE3 and basolateral XNHE. These effects were mimicked by the addition of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and partially prevented by the PKC inhibitor calphostin C which also blocked the effect of PMA. 5. Stimulation of the basolateral A2 receptor with CPA inhibited apical NHE3 and stimulated basolateral XNHE. These effects were mimicked by 8-bromo-cAMP and partially prevented by the PKA inhibitor H89 which entirely blocked the effect of 8-bromo-cAMP. 6. In conclusion, CPA inhibits rat NHE3 expressed apically in A6 epithelia via both the apical PKC-coupled A1 and the basolateral PKA-coupled A2 adenosine receptors.  (+info)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (3/2198)

OBJECTIVE: We have studied the mechanisms underlying the positive inotropic action of prostaglandin F2 alpha (PGF2 alpha) by monitoring intracellular calcium transients, intracellular pH, L-type calcium currents and cell shortening in isolated ventricular myocytes. METHODS: Rat myocytes were loaded with fura-2AM for intracellular calcium measurements, or BCECF-AM for pH measurements. Cell shortening was recorded using an edge detection system, and L-type calcium currents measured using whole cell patch clamping. RESULTS: PGF2 alpha (3 nmol l-1-3 mumol l-1 increased single myocyte shortening and reduced resting cell length in a concentration-dependent manner. While myocyte shortening was increased by PGF2 alpha, this was not associated with any change in the amplitude of intracellular calcium transients, diastolic calcium, or L-type calcium currents. However, the same myocytes were capable of responding to catecholamines with increases in calcium transient amplitude and L-type calcium currents. PGF2 alpha (3 mumol l-1 caused a reversible rise in intracellular pH of 0.08 +/- 0.01 pH units (n = 5, p < 0.05). The Na(+)-H+ exchanger inhibitor, HOE 694 (10 mumol l-1, abolished the PGF2 alpha-induced rise in pH and the increase in cell shortening. PGF2 alpha-induced increases in cell shortening and intracellular pH were also attenuated by the protein kinase C (PKC) inhibitor, chelerythrine (2 mumol l-1. CONCLUSION: The positive inotropic action of PGF2 alpha appears to be mediated via activation of the Na(+)-H+ exchanger with the possible involvement of PKC. This suggests that PGF2 alpha-produces intracellular alkalosis, which then sensitizes cardiac myofilaments to calcium.  (+info)

Implication of endogenous nitric oxide in gastric mucosal protective effect of T-593, a novel anti-ulcer agent, in rats. (4/2198)

The relationship of endogenous nitric oxide (NO) to the gastric mucosal protective effect of the novel anti-ulcer agent T-593, (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5-(methylamino) methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine, was investigated in rats. T-593 (3-30 mg/kg, p.o.) dose dependently prevented the formation of gastric mucosal lesions induced by oral administration of aspirin (200 mg/kg) in 0.15 N HCl (HCl-aspirin). Pretreatment with N(G)-nitro-L-arginine methylester (L-NAME), a selective inhibitor of NO synthase (NOS), attenuated the mucosal protective effect of T-593. This effect of L-NAME was antagonized by pretreatment with L-arginine, a substrate of NOS, but not with D-arginine. Activity of total NOS composed of inducible and constitutive NOS in the gastric mucosa was decreased by HCl-aspirin, and T-593 inhibited this decrease. On the other hand, HCl-aspirin and T-593 did not affect inducible NOS activity in the gastric mucosa. Furthermore, we confirmed that T-593 inhibits the decrease in gastric mucosal blood flow (GMBF) induced by HCl-aspirin, and this effect is completely inhibited by pretreatment with L-NAME. These results suggest that the mucosal protective effect of T-593 is partly mediated by endogenous NO via improvement of GMBF and that a possible mechanism for the effect of T-593 is the maintenance of constitutive NOS activity in gastric mucosa.  (+info)

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes. (5/2198)

We investigated the cytochrome P-450-dependent metabolism of 1, 1-dichloroethylene (DCE) by human lung and liver microsomes and compared the results from analogous experiments in mice. Metabolites were identified by HPLC analysis of their glutathione conjugates and/or hydrolyzed products and were detected by using [14C]DCE. The role of human CYP2E1 in the metabolic reactions was examined by comparing p-nitrophenol hydroxylase activities with levels of metabolites formed and by using the CYP2E1-selective inhibitor diallyl sulfone. The major products formed in microsomal incubations containing NADPH were the DCE-epoxide-derived glutathione conjugates 2-(S-glutathionyl)acetyl glutathione and 2-S-glutathionyl acetate. Lower levels of the acetal of 2,2-dichloroacetaldehyde were also detected. In lung samples from eight patients, the amounts of epoxide-derived conjugates formed ranged from 15.6 +/- 4.23 to 34.9 +/- 12.75 pmol/mg protein/min. The levels in murine lung were higher at 40.0 +/- 3.8 pmol/mg protein/min. In liver samples from five patients, conjugate levels ranged from 46.5 +/- 8.3 to 240.0 +/- 10. 5 pmol/mg protein/min, whereas levels in murine liver were 83.0 +/- 6.2 pmol/mg protein/min. Conjugate levels formed in human liver correlated with the relative levels of p-nitrophenol hydroxylase activity present, but this relationship was equivocal in human lung. Diallyl sulfone inhibited the formation of the glutathione conjugates (20-65%) in liver samples from all four patients, whereas only one of five human lung samples exhibited this inhibition (27%). These results demonstrated that the DCE-epoxide is a major metabolite formed by human microsomes and is mediated by CYP2E1 in liver and in some individuals in lung.  (+info)

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. (6/2198)

Conventional nonsteroidal anti-inflammatory drugs inhibit both cyclooxygenase (Cox) isoforms (Cox-1 and Cox-2) and may be associated with nephrotoxicity. The present study was undertaken to assess the renal effects of the specific Cox-2 inhibitor, MK-966. Healthy older adults (n = 36) were admitted to a clinical research unit, placed on a fixed sodium intake, and randomized under double-blind conditions to receive the specific Cox-2 inhibitor, MK-966 (50 mg every day), a nonspecific Cox-1/Cox-2 inhibitor, indomethacin (50 mg t.i.d.), or placebo for 2 weeks. All treatments were well tolerated. Both active regimens were associated with a transient but significant decline in urinary sodium excretion during the first 72 h of treatment. Blood pressure and body weight did not change significantly in any group. The glomerular filtration rate (GFR) was decreased by indomethacin but was not changed significantly by MK-966 treatment. Thromboxane biosynthesis by platelets was inhibited by indomethacin only. The urinary excretion of the prostacyclin metabolite 2,3-dinor-6-keto prostaglandin F1alpha was decreased by both MK-966 and indomethacin and was unchanged by placebo. Cox-2 may play a role in the systemic biosynthesis of prostacyclin in healthy humans. Selective inhibition of Cox-2 by MK-966 caused a clinically insignificant and transient retention of sodium, but no depression of GFR. Inhibition of both Cox isoforms by indomethacin caused transient sodium retention and a decline in GFR. Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1.  (+info)

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. (7/2198)

The mature form of the cathepsin B-like protease of Leishmania major (LmajcatB) is a 243 amino acid protein belonging to the papain family of cysteine proteases and is 54% identical to human-liver cathepsin B. Despite the high identity and structural similarity with cathepsin B, LmajcatB does not readily hydrolyse benzyloxycarbonyl-Arg-Arg-7-amino-4-methyl coumarin (Z-Arg-Arg-AMC), which is cleaved by cathepsin B enzymes. It does, however, hydrolyse Z-Phe-Arg-AMC, a substrate typically cleaved by cathepsin L and B enzymes. Based upon computer generated protein models of LmajcatB and mammalian cathepsin B, it was predicted that this variation in substrate specificity was attributed to Gly234 at the S2 subsite of LmajcatB, which forms a larger, more hydrophobic pocket compared with mammalian cathepsin B. To test this hypothesis, recombinant LmajcatB was expressed in the Pichia pastoris yeast expression system. The quality of the recombinant enzyme was confirmed by kinetic characterization, N-terminal sequencing, and Western blot analysis. Alteration of Gly234 to Glu, which is found at the corresponding site in mammalian cathepsin B, increased recombinant LmajcatB (rLmajcatB) activity toward Z-Arg-Arg-AMC 8-fold over the wild-type recombinant enzyme (kcat/Km=3740+/-413 M-1.s-1 versus 472+/-72.4 M-1.s-1). The results of inhibition assays of rLmajcatB with an inhibitor of cathepsin L enzymes, K11002 (morpholine urea-Phe-homoPhe-vinylsulphonylphenyl, kinact/Ki=208200+/-36000 M-1. s-1), and a cathepsin B specific inhibitor, CA074 [N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-l-isoleucyl-l- prolin e, kinact/Ki=199200+/-32900 M-1.s-1], support the findings that this protozoan protease has the P2 specificity of cathepsin L-like enzymes while retaining structural homology to mammalian cathepsin B.  (+info)

Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats. (8/2198)

Male Sprague-Dawley rats received four consecutive intraperitoneal (i.p.) doses of five kinds of methylsulfonyl (MeSO2) metabolites of tetra- and pentachlorinated biphenyls (tetra- and pentaCBs) to determine their effects on thyroid hormone levels. The five MeSO2 metabolites, which were the major MeSO2-PCBs detected in human milk, liver and adipose tissue were 3-MeSO2-2,2',4',5-tetraCB (3-MeSO2-CB49),3-MeSO2-2,3',4',5-tetraCB (3-MeSO2-CB70), 3-MeSO2-2,2',3',4',5-pentaCB (3-MeSO2-CB87), 3-MeSO2-2,2',4',5,5'-pentaCB (3-MeSO2-CB101), and 4-MeSO2-2,2',4',5,5'-pentaCB (4-MeSO2-CB101). All five tested MeSO2 metabolites (20 mumol/kg once daily for 4 days) reduced serum total thyroxine levels 16-40% on days 2, 3, 4, and 7 (after the last dosage). The total triiodothyronine level was reduced 37% by treatment with 3-MeSO2-CB49 at day 7, but was increased 35% and 38% by 3-MeSO2-CB70 and 4-MeSO2-CB101 at days 3 and 4, respectively. The reductions in thyroid hormone levels led to an increase in thyroid stimulating hormone (TSH) levels by 3-MeSO2-CB49, 3-MeSO2-CB87 and 3-MeSO2-CB101. A 30% increase in thyroid weight was produced by 3-MeSO2-CB101 treatment. Thus, it is likely that all five tested MeSO2 metabolites could influence thyroid hormone metabolism. The results show that the tested 3- and 4-MeSO2 metabolites of tetra- and pentaCBs reduce thyroid hormone levels in rats, suggesting that the metabolites may act as endocrine-disrupters.  (+info)

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Roy K (2002). "Sulfones and Sulfoxides". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/ ... In these oxidations, care is required to avoid over oxidation to form a sulfone. Dimethyl sulfide is oxidized to dimethyl ... H2O Sulfoxides can be oxidized to sulfones using peroxide: OSR2 + H2O2 → O2SR2 + H2O The α-CH groups of alkyl sulfoxides are ... sulfoxide and then further to dimethyl sulfone. Unsymmetrical sulfides are prochiral, thus their oxidation gives chiral ...
The Ramberg-Bäcklund reaction is an organic reaction converting an α-halo sulfone into an alkene in presence of a base with ... The original procedure involved halogenation of a sulfide, followed by oxidation to the sulfone. Recently, the preferred method ... doi:10.1016/S0040-4020(01)01224-8. ^ Paquette, Leo A.; Philips, J. Christopher; Wingard, Robert E. (1971). "α-Halo sulfones. ... The sulfone group contains an acidic proton in one of the α-positions which is abstracted by a strong base (scheme 1). The ...
It is an intramolecular nucleophilic aromatic substitution of the type: where X in the arene compound can be a sulfone, a ... This reaction is exemplified by the conversion of an aryl sulfone into a sulfinic acid by action of n-butyllithium: This ... Truce, William E.; Ray, William J.; Norman, Oscar L.; Eickemeyer, Daniel B. (July 1958). "Rearrangements of Aryl Sulfones. I. ... The Metalation and Rearrangement of Mesityl Phenyl Sulfone". Journal of the American Chemical Society. 80 (14): 3625-3629. doi: ...
Application to the Synthesis of Sulfones". Organic Letters. 1 (8): 1177-1180. doi:10.1021/ol990170k. v t e. ... as well as oxidation of thiols to sulfones. It is named for Franklin A. Davis. Davis, Franklin A.; Vishwakarma, Lal C.; ...
It is of the sulfone class. Dapsone was first studied as an antibiotic in 1937. Its use for leprosy began in 1945. It is on the ... 2001). "Dapsone and sulfones in dermatology: overview and update". Journal of the American Academy of Dermatology. 45 (3): 420- ... The sulfone syndrome revisited". Arch Dermatol. 117 (1): 38-9. doi:10.1001/archderm.1981.01650010044023. PMID 6450569. Kromann ... Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and ...
It can be oxidised to a sulfoxide with calcium hypochlorite or sodium periodate, or continuing to a sulfone. It can react with ... 2008). "Product Subclass 2: Cyclic Dialkyl Sulfones and Derivatives". Category 5, Compounds with One Saturated Carbon ...
At first, a specific sulfone is formed in 22 steps of common chemistry. This sulfone is coupled with a straightforward epoxide ... This coupling reaction is most efficient when the sulfone is transformed into a dianion with n-butyllithium, followed by ... Hereby, a diastereomeric mixture of sulfones is formed. After reductive desulfurization and methylation, the formation of a ...
"Sulfones expand the reach of radical cross-couplings , January 8, 2018 Issue - Vol. 96 Issue 2 , Chemical & Engineering News". ...
Sulfoxides and sulfones are thioethers with one and two oxygen atoms attached to the sulfur atom, respectively. The simplest ... sulfoxide, dimethyl sulfoxide, is a common solvent; a common sulfone is sulfolane. Sulfonic acids are used in many detergents. ...
ISBN 978-3-527-32669-3. Wozel, Gottfried (1989). "The Story of Sulfones in Tropical Medicine and Dermatology". International ...
For example, it converts thioethers into sulfoxides and sulfones. In the European Union, sodium perborate, like most borates, ...
Stork, G; Borowitz, IJ (1962). "Four-membered Sulfones from Enamines and Aliphatic Sulfonyl Halides". J. Am. Chem. Soc. 84 (2 ... in a catalytic asymmetric synthesis of β-sulfones (four-membered ring sulfonate esters). Sulfene can also undergo insertion ...
"Current Data on Promin Therapy; reprinted in The Star October-December 2003" (PDF). Wozel G (1989). "The story of sulfones in ... Promin, or sodium glucosulfone is a sulfone drug that was investigated for the treatment of malaria, tuberculosis and leprosy. ... The medical evaluation of sulfones was inspired by the discovery of the unprecedented value of synthetic compounds such as ... Promin and other sulfones can also not be used as substitutes for dapsone when intolerance develops, as this is a general ...
It has also been used in organic chemistry as electrophile to transform sulfones into aldehydes. MNP is also an efficient ... "A Protocol To Transform Sulfones into Nitrones and Aldehydes". Organic Letters. 20 (18): 5789-5793. doi:10.1021/acs.orglett. ...
DMSO is metabolized by disproportionation to dimethyl sulfide and dimethyl sulfone. It is subject to renal and pulmonary ... Chakrabarti R, Schutt CE (August 2001). "The enhancement of PCR amplification by low molecular-weight sulfones". Gene. 274 (1-2 ... "Sulfones and Sulfoxides" in Ullmann's Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. doi:10.1002/14356007.a25 ... SO2 and sulfate Dimethyl sulfone, commonly known as methylsulfonylmethane (MSM), a related chemical often marketed as a dietary ...
... 1,1-dioxides are sulfones, the parent being C3H4SO2. They are more stable than the parent thietes. Substituted thiete-1, ...
Successive oxidation then leads to the sulfone. Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names ...
V. ITC with sulphide and sulphone groups". Neoplasma. 17 (1): 3-8. PMID 4986664. Horáková, K; Drobnica, L; Nemec, P (1970). " ...
Künzer, H (1991). "Reductive desulfonylation of phenyl sulfones by samarium(II) iodide-hexamethylphosphoric triamide". ...
... sulfone. Such solutions are shelf-stable indefinitely. Sodium hydroxymethanesulfinate was originally developed in the early ... dibromoxylene gives both the sulfone and the isomeric sulfinate ester. The original use of the compound was as industrial ... NaHOCH2SO2 reacts with alkylating agents to give sulfones. HO-CH2-SO2Na + 2 C6H5CH2Br → [C6H5CH2]2SO2 + NaBr + CH2O + HBr ...
HIROI, Kunio; HIRASAWA, Kazushige (1994). "Palladium-Catalyzed Intramolecular Metallo-Ene Reactions Using Allylic Sulfones as ...
McLaughlin, N. P.; Evans, P. (2010). "Dihydroxylation of Vinyl Sulfones: Stereoselective Synthesis of (+)- and (−)-Febrifugine ...
Some of these include MK-7655, NXL104, and 6-alkylidenepenam sulfones. The exact way they affect the carbapenemases is unknown ...
Phenyl vinyl sulfone as a ketene synthetic equivalent". Tetrahedron Letters. 21 (35): 3339-3342. doi:10.1016/s0040-4039(00) ... In the case of sulfones, alpha-hydroxylation leads directly to the ketone or aldehyde. Common byproducts of the alpha- ...
It acts by inhibiting the enzyme cyclic guanosine monophosphate phosphodiesterase type 5 (EC 3.1.4.17). It is the sulfone ... Sulindac "Exisulind: Aptosyn, FGN 1, Prevatac, sulindac sulfone". Drugs in R&D. 5 (4): 220-6. 2004. doi:10.2165/00126839- ... Sulindac Sulfone, FGN-1) as a chemopreventive agent in patients with familial adenomatous polyposis". Clinical Cancer Research ... "Inhibition of Angiogenesis by Sulindac and its Sulfone Metabolite (FGN-1): a Potential Mechanism for Their Antineoplastic ...
It entered early Western medicine in the 19th-century before the era of sulfones and antibiotics for the treatment of several ... In the 1940s chaulmoogra oil was replaced by the more effective sulfones. The oil contains 5′-methoxyhydnocarpin, an ...
Sulfones are bacteriostatic and are used only in the treatment of leprosy. Dapsone (Avlosulfon) is the most widely used sulfone ... Clofazimine is given to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones. It also exerts an ... The sulfones tend to remain in the skin, muscle, kidney, and liver up to 3 weeks after therapy is stopped. The concentration in ... The sulfones are acetylated in the liver, and 70 to 80% of drug is excreted in the urine as metabolites. Dapsone, combined with ...
A sulfonyl group can refer either to a functional group found primarily in sulfones or to a substituent obtained from a ... Lithium aluminium hydride (LiAlH4) reduces some but not all sulfones to sulfides. In inorganic chemistry, when the group −S(=O) ...
... is a heavily modified penicillin and a sulfone. Tazobactam was patented in 1982 and came into medical use in 1992. ...
The replacement of the phenyl sulfones with heteroaryl sulfones greatly alters the reaction pathway.[13] The most popular ... The reaction of the benzothiazole sulfone (1) with lithium diisopropylamide (LDA) gives a metallated benzothiazolyl sulfone, ... The phenyl sulfone anion (2) reacts with an aldehyde to form the alkoxide (3). The alkoxide is functionalized with R3-X to give ... However, purification of the sulfone intermediate 2 leads to higher yield and purity. Most often R3 is acetyl or benzoyl, with ...
Precursors to such polymers are the sulfones bisphenol S and 4,4′-dichlorodiphenyl sulfone. Examples of sulfones in ... Sulfones have been prepared by nucleophilic displacement of halides by sulfinates: ArSO2Na + ArCl → Ar(Ar)SO2 + NaCl Sulfone ... A sulfone is a chemical compound containing a sulfonyl functional group attached to two carbon atoms. The central hexavalent ... Sulfones are prepared under conditions used for Friedel-Crafts reactions using sources of RSO+ 2 derived from sulfonyl halides ...
Modafinil sulfone is also a metabolite of armodafinil, the (R)-(-)-enantiomer of modafinil, as oxidation to the sulfone removes ... Modafinil sulfone has been described as inactive, and similarly to modafinil acid, does not appear to contribute to the ... Modafinil sulfone (code name CRL-41056) is an achiral, oxidized metabolite of modafinil, a wakefulness-promoting agent. It is ... Chatterjie N, Stables JP, Wang H, Alexander GJ (2004). "Anti-narcoleptic agent modafinil and its sulfone: a novel facile ...
Other names: Propane, 1,1-sulfonylbis[2-methyl-; Isobutyl sulfone; 1,1-Sulphonylbis(2-methyl-propane); Diisobutyl sulphone; ( ...
Other names: Benzene, 1,1-sulfonylbis-; Phenyl sulfone; DPS; Sulfobenzide; Sulfone, diphenyl; Difenylsulfon; Diphenyl sulphone ...
Sulfoxides, Sulfones, and Sulfur Acids. Sulfoxides and Sulfones Rule C-631 631.1 - Compounds and are named "sulfoxides" and " ... Sulfoxides and Sulfones Rule C-632, Rule C-633. Sulfur Acids and Their Derivatives Containing Sulfur Directly Linked to an ... in alphabetical order) before "sulfoxide" or "sulfone". Alternatively compounds and may be named from the radical R1 followed ... "sulfones", respectively. Specific names are formed by placing the names of the radicals and ( ...
Aldicarb sulfone. Find out what is in your tap water ... EWGs Tap Water Database Aldicarb sulfone results for Genoa ... Aldicarb sulfone. Genoa City Waterworks. Aldicarb sulfone is a groundwater contaminant and a neurotoxic metabolite of the ...
Phenyl sulfone; Linear Formula: (C6H5)2SO2; Empirical Formula: C12H10O2S; find related products, papers, technical documents, ...
Sulfone polymers are high-heat transparent plastics with offer more toughness, strength and hydrolytic stability than other ... Sulfone polymers are noted for high heat deflection temperatures (HDT) and outstanding dimensional stability. These strong, ...
Aldicarb sulfone. Find out what is in your tap water ... EWGs Tap Water Database Aldicarb sulfone results for ... Aldicarb sulfone. Montgomery County UD 4. Aldicarb sulfone is a groundwater contaminant and a neurotoxic metabolite of the ...
Methylphenethyl sulfone , C9H12O2S , CID 12424890 - structure, chemical names, physical and chemical properties, classification ...
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.. Kerr ID1, Lee JH, Farady CJ, Marion R, Rickert ... Phenyl sulfone flipping in the rhodesain·K11777 complex. Ribbon representation and detailed inlay of the S1′ subsites of ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ... Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design ...
A new class of polyalkylene oxide vinyl sulfone reagents is described. Also described are a method by which these reagents can ... with a protein to form a PAO-to-sulfone-to-protein conjugate. When the difunctional sulfone is divinyl sulfone and the ... Any excess divinyl sulfone can be removed from the polyalkylene oxide vinyl sulfone reagent by washing the latter in a solvent ... can be activated and reacted with a difunctional sulfone such as a divinyl sulfone to provide a polymeric reagent comprising ...
... Forecast Report 2017-2024 - published on openPR.com ... Diphenyl Sulfone Market Segment Analysis and Forecast by 2025 Global Diphenyl Sulfone Market: Snapshot Diphenyl sulfone finds ... Sulfone Polymers Market Analysis : TMR Global Sulfone Polymers Market: Snapshot Several grades/varieties of sulfone polymers ... Sulfone Polymers Market Research Report 2016 Global Sulfone Polymers Market: Overview Sulfone polymers are high performance ...
4-Chlorophenyl phenyl sulfone for your research needs. Find product specific information including CAS, MSDS, protocols and ... 4-Chlorophenyl phenyl sulfone was employed in polyetherification reaction of 4,4′-dihalodiphenyl sulfones. ... 4-Chlorophenyl phenyl sulfone is also referred to as sulphenone. It participates in palladium-catalyzed amidation reaction in ...
A sulfone is a molecule that has a sulfur atom with bonds to two oxygen atoms. The sulfur has two double bonds to the two ... For example, the Julia olefination uses a sulfone to make an alkene from an aldehyde. They are also sometimes used as solvents. ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Sulfone&oldid=4295053" ...
MPSU stands for Modified Poly Sulfone. MPSU is defined as Modified Poly Sulfone very rarely. ... 2020 https://www.acronymfinder.com/Modified-Poly-Sulfone-(MPSU).html. *Chicago style: Acronym Finder. S.v. "MPSU." Retrieved ... n.d.) Acronym Finder. (2020). Retrieved December 2 2020 from https://www.acronymfinder.com/Modified-Poly-Sulfone-(MPSU).html ... a href=https://www.acronymfinder.com/Modified-Poly-Sulfone-(MPSU).html,MPSU,/a,. ...
The log Pow of diphenyl sulfone is 2.60. The bioaccumulation potential of diphenyl sulphone is low. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The bioaccumulation potential of diphenyl sulphone is low and an adsorption/desorption study does not have to be conducted. ...
Based on the results of an independent source, Merck index 13th ed, it can be concluded to that diphenyl sulphone is a white ... it can be concluded that diphenyl sulphone are white monoclinic prisms or leaflets. ...
alpha-Phenylphenethyltrifluoromethyl sulfone , C15H13F3O2S , CID 71365738 - structure, chemical names, physical and chemical ...
Crystallization of the tetrabromo sulfone is difficult since it is insoluble in many solvents and it has a tendency to remain ... Process for preparing bisphenol sulfone derivatives. US4291177 *. Dec 6, 1979. Sep 22, 1981. General Electric Company. Process ... It is usually available as a crude product containing 5-20% or more of tri-, di-, and monobromo sulfones as impurities. ... The present invention relates to a procedure for the purification of crude tetrabromobisphenol sulfone (hereinafter referred to ...
Sulfone, 500g (46AH14)? Graingers got your back. Price:$2079.57. Easy ordering & convenient delivery. Log-in or register for ...
The Global Sulfone Polymers Industry Report 2015 is a professional and in-depth study on the current s - Market Research ... 1.2 Classification of Sulfone Polymers. 1.3 Applications of Sulfone Polymers. 1.4 Industry Chain Structure of Sulfone Polymers ... Figure Picture of Sulfone Polymers. Table Product Specifications of Sulfone Polymers. Table Classification of Sulfone Polymers ... The Global Sulfone Polymers Industry Report 2015 is a professional and in-depth study on the current state of the Sulfone ...
This report studies Sulfone Polymers in Global market, especially in North America, Europe, China, Japan, Southeast Asia and ... 1 Sulfone Polymers Market Overview. 1.1 Product Overview and Scope of Sulfone Polymers. 1.2 Sulfone Polymers Segment by Type. ... 2.5 Sulfone Polymers Market Competitive Situation and Trends. 2.5.1 Sulfone Polymers Market Concentration Rate. 2.5.2 Sulfone ... 7.7.2 Sulfone Polymers Product Type, Application and Specification. 7.7.2.1 Type I. 7.7.2.2 Type II. 7.7.3 Sino Polymer Sulfone ...
Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands.. Tong L1, Shankar BB, Chen L, Rizvi R, Kelly ... We report further expansion of the structure activity relationship (SAR) on the triaryl bis sulfone class of compounds (I), ...
... gas mixture with a membrane containing a thin dense discriminating layer comprising a polymer of sulphonated polyether sulphone ... Membranes of polyether sulfone and sulfonated polyether sulfone are prepared by solution casting. About 1.5 g of the dried ... Preferably, the percentage of sulfonated sulfone units in the polymer is between about 1 and 20 percent of the sulfone units. ... 4. The method of claim 3 wherein between about 1 and about 20 percent of the sulfone units in the polymer contain pendant ...
Sulfone Metabolite of Sulindac Inhibits Mammary Carcinogenesis. Henry J. Thompson, Cheng Jiang, Junxuan Lu, Rajendra G. Mehta, ... Sulfone Metabolite of Sulindac Inhibits Mammary Carcinogenesis. Henry J. Thompson, Cheng Jiang, Junxuan Lu, Rajendra G. Mehta, ... Sulfone Metabolite of Sulindac Inhibits Mammary Carcinogenesis. Henry J. Thompson, Cheng Jiang, Junxuan Lu, Rajendra G. Mehta, ... Sulindac sulfone was incorporated into a purified diet at a concentration of either 0.03 or 0.06% (w/w) and fed to rats ...
Vinyl Sulfone Market is estimated to surpass ~US$ 2.4 Bn by 2027 Global Vinyl Sulfone Market: Key Highlights  The global vinyl ... Key Drivers of Vinyl Sulfone Market  Vinyl sulfone is a cross-linker reagent used as a raw material for the manufacturing of ... The global vinyl sulfone market was valued at ~US$ 1.7 Mn in 2018, and is anticipated to expand at a CAGR of ~4% from 2019 to ... The textile industry majorly uses reactive dyes, and vinyl sulfone is popularly employed in the manufacturing of reactive dyes ...
Next, phenolphthalein-based poly(arylene ether sulfone)/PSM composites... ... Lin CX, Zhuo YZ, Lai AN, Zhang QG, Zhu AM, Liu QL (2016) Comb-shaped phenolphthalein-based poly(ether sulfone)s as anion ... Rao AHN, Kim HJ, Nam S, Kim TH (2013) Cardo poly(arylene ether sulfone) block copolymers with pendant imidazolium side chains ... Mi Y, Feng J, Chan C-M, Guo Q (1997) Blends of phenolphthalein poly (ether ether sulfone) with a thermotropic liquid ...
  • We report further expansion of the structure activity relationship (SAR) on the triaryl bis sulfone class of compounds (I), which are potent CB(2) receptor ligands with excellent selectivity over the CB(1) receptor. (nih.gov)
  • report a class of easily prepared, solid sulfone compounds that engage in nickel-catalyzed coupling of their fluoroalkyl groups with aryl zinc reagents. (sciencemag.org)
  • A combination of o -iodoxybenzoic acid (IBX) and a catalytic amount of iodine promotes a facile one-pot deacylative sulfonylation reaction of 1,3-dicarbonyl compounds with sodium sulfinates to yield β-carbonyl sulfones in good yields. (organic-chemistry.org)
  • A cross-coupling reaction between sulfonyl hydrazides and diazo compounds provides various β-carbonyl sulfones in good yields. (organic-chemistry.org)
  • Three C-2-substituted penicillin sulfone compounds (JDB/LN-1-255, JDB/LN-III-26, and JDB/ASR-II-292) showed low K i values for the OXA-1 β-lactamase (0.70 ± 0.14 → 1.60 ± 0.30 μM) and demonstrated significant K i improvements compared to the C-3-substituted cephalosporin sulfone (JDB/DVR-II-214), tazobactam, and clavulanic acid. (asm.org)
  • Optimal antimalarial compounds, which inhibited P. falciparum development at low nanomolar concentrations, were phenyl vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides with P2 leucine moieties. (edu.mx)
  • These compounds are more potent in living cells than their shorter peptide vinyl sulphone counterparts. (enzolifesciences.com)
  • Sulfone polymers are compounds consisting of -SO2 or sulfone moiety bonds. (verifiedmarketresearch.com)
  • Polarised light microscopy footage of the formation and growth of crystals of the chemical methyl sulfone (methylsulfonylmethane). (sciencephoto.com)
  • Ethyl methyl sulfone, ethyl isopropyl sulfone, and 3-methyl sulfolane are new polar solvents developed with organic sulfur compound synthesis technology of SUMITOMO SEIKA CHEMICALS. (sumitomoseika.co.jp)
  • Rao AHN, Kim HJ, Nam S, Kim TH (2013) Cardo poly(arylene ether sulfone) block copolymers with pendant imidazolium side chains as novel anion exchange membranes for direct methanol alkaline fuel cell. (springer.com)
  • Synthesis of highly sulfonated poly(arylene ether sulfone) random (statistical) copolymers via direct polymerization," Macromolecular Symposia , vol. 175, pp. 387-395, 2001. (hindawi.com)
  • Through-plane morphologies of multiblock copolymers based on poly(arylene ether sulfone)s were investigated by transmission electron microscopy (TEM) and through-plane conductivity measurements using a 4-probe method. (lu.se)
  • article{cbdb2a91-b0fa-411f-a2c3-3805d7047d52, abstract = {Through-plane morphologies of multiblock copolymers based on poly(arylene ether sulfone)s were investigated by transmission electron microscopy (TEM) and through-plane conductivity measurements using a 4-probe method. (lu.se)
  • Novel bisphenol-based wholly aromatic poly(ether ketone)/poly(ether sulfone) copolymers containing pendant sulfonate groups were prepared by direct aromatic nucleophilic substitution polycondensation of 4,4-difluoro-3,3'-disodiumsulfonylbenzophenone (40mol% of bisphenol), difluorophenylsulfone and bisphenol A. Organic-inorganic composite membranes were obtained by mixing organic polymers with hydrophilic SiO2 (ca. 20nm) obtained by sol-gel process. (scientific.net)
  • Disulfonated poly(arylene ether sulfone)s (BPS) random copolymers have been used as membranes for purifying water and generating electricity. (elsevier.com)
  • Next, phenolphthalein-based poly(arylene ether sulfone)/PSM composites (PES-C/PSM) were fabricated. (springer.com)
  • Chen G, Zhang X, Zhang S, Chen T, Wu Y (2007) Synthesis, properties, and gas permeation performance of cardo poly(arylene ether sulfone)s containing phthalimide side groups. (springer.com)
  • Lin CX, Zhuo YZ, Lai AN, Zhang QG, Zhu AM, Liu QL (2016) Comb-shaped phenolphthalein-based poly(ether sulfone)s as anion exchange membranes for alkaline fuel cells. (springer.com)
  • Lai AN, Zhuo YZ, Lin CX, Zhang QG, Zhu AM, Ye ML, Liu QL (2016) Side-chain-type phenolphthalein-based poly(arylene ether sulfone nitrile)s anion exchange membrane for fuel cells. (springer.com)
  • Dong X, Hou S, Mao H, Zheng J, Zhang S (2016) Novel hydrophilic-hydrophobic block copolymer based on cardo poly (arylene ether sulfone)s with bis-quaternary ammonium moieties for anion exchange membranes. (springer.com)
  • Fluorene-based poly(arylene ether sulfone)s containing clustered flexible pendant sulfonic acids as proton exchange membranes," Macromolecules , vol. 44, no. 18, pp. 7296-7306, 2011. (hindawi.com)
  • A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. (freepatentsonline.com)
  • 1. A water soluble activated polymer that is stable against hydrolysis, said polymer being selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), and poly(olefinic alcohols) and having at least one active sulfone moiety. (freepatentsonline.com)
  • 5. The activated polymer of claim 1 wherein said polymer is poly(ethylene glycol) vinyl sulfone. (freepatentsonline.com)
  • Poly(arylene ether sulfone) (PSU) ionomers containing disulfonated aryl-SO2-aryl and tetrasulfonated aryl-SO2-aryl-aryl-SO2-aryl segments, respectively, were synthesized and studied to establish their structure-property relationships as proton-exchange membranes. (lu.se)
  • Poly-phenylene sulfones constitute chemically and mechanically stable polymer backbones. (mpg.de)
  • Abstract: Novel bisphenol-based wholly aromatic sulfonated poly(ether sulfone-ketone) copolymer and organic-inorganic composite membranes were prepared for operation 80°C in polymer electrolyte membrane fuel cell (PEMFCs). (scientific.net)
  • Room-Temperature High-Efficiency Solid-State Triplet-Triplet Annihilation Up-Conversion in Amorphous Poly (olefin sulfone)s. (bentham.co.uk)
  • The four poly(olefin sulfone) hosts were loaded with upconversion dyes, and absolute quantum yields of TTA-UC (η TTA-UC ) were measured. (bentham.co.uk)
  • The highest value of η TTA-UC = 2.1% was measured for poly(1-dodecene sulfone). (bentham.co.uk)
  • Relatively long T2 times measured for poly(olefin sulfone)s indicate an enhanced nanoscale fluidity in the studied (co)polymers, which unexpectedly coexists with a rigidity on the macroscale. (bentham.co.uk)
  • Poly(ether sulfones) PES for short, are high performance polymers. (blogspot.com)
  • Poly(ether sulfones) act a lot like polycarbonates, but they're a lot more heat resistant. (blogspot.com)
  • Poly(ether sulfones) also can stand up well to water and steam, so they're used to make things like cookware and medical products that need to be sterilized between uses. (blogspot.com)
  • For example, dimethyl sulfide oxidizes to dimethyl sulfoxide and then to dimethyl sulfone. (wikipedia.org)
  • During its metabolism, the inactive prodrug sulindac sulfoxide undergoes either reduction to the active anti-inflammatory metabolite sulindac sulfide or irreversible oxidation to sulindac sulfone, which lacks prostaglandin synthetase inhibitory activity. (aacrjournals.org)
  • The sulfone reduced cancer incidence and the number of cancers per rat irrespective of the dose of MNU injected, and its chemopreventive activity was comparable to that of sulindac sulfoxide. (aacrjournals.org)
  • Using a mammary gland organ culture transformation assay, it was observed that sulindac sulfone also inhibited the formation of 7,12-dimethylbenz( a )anthracene-induced hyperplastic alveolar nodules and that the inhibitory activity of the sulfone was comparable to that of the sulfoxide. (aacrjournals.org)
  • To test this hypothesis, MCF-7 cells were exposed to a range of concentrations of sulindac sulfone and sulfoxide. (aacrjournals.org)
  • The bioaccumulation potential of diphenyl sulphone is low. (europa.eu)
  • The bioaccumulation potential of diphenyl sulphone is low and an adsorption/desorption study does not have to be conducted. (europa.eu)
  • Based on the results of an independent source, Merck index 13th ed, it can be concluded to that diphenyl sulphone is a white monoclinic prisms or leaflets. (europa.eu)
  • According to the information of an independent sources (Merck index 13 th ed Rahway New jersey Merck Co inc 2006 ref 3365 p 586 & Hawley's Condensed Chemical Dictionary, 11th edition, 1987 Van Nostrand Reinhold Company, p 430) it can be concluded that diphenyl sulphone are white monoclinic prisms or leaflets. (europa.eu)
  • Studies on the toxicity and the action of Diamino-Diphenyl Sulphone (‎DDS)‎ in Avian and Simian Malaria. (who.int)
  • 1961)‎. Studies on the toxicity and the action of Diamino-Diphenyl Sulphone (‎DDS)‎ in Avian and Simian Malaria. (who.int)
  • WHO IRIS: Studies on the toxicity and the action of Diamino-Diphenyl Sulphone (DDS) in Avian and Simian Malaria. (who.int)
  • The plasma diphenyl sulphone levels of treated animals showed a positive but non-linear correlation with dose. (europa.eu)
  • Circulating levels of diphenyl sulphone were comparable at the week 1 and 12 investigations for the 100 and 200 ppm dosed group. (europa.eu)
  • However, during week 12 group 2000 ppm dosed males showed a fall in plasma level when compared to week 1, whilst the plasma diphenyl sulphone level of 2000 ppm dosed females rose against the week 1 value. (europa.eu)
  • However, on the basis of the fact that circulating levels of diphenyl sulphone were comparable in week 1 and 12 for the 100 and 200 ppm dosed groups, no accumulation is assumed and e limination is expected to take place by biliary or urinary route. (europa.eu)
  • Treatment of dermatitis herpetiformis with diamino-diphenyl-sulphone (D.D.S. (semanticscholar.org)
  • The synthesis of vinyl sulfones via silver-promoted cross-coupling of vinyl bromides with sulfonyl hydrazides was realized. (rsc.org)
  • Here, we report the use of sulfones to activate the alkyl coupling partner in nickel-catalyzed radical cross-coupling with aryl zinc reagents. (sciencemag.org)
  • The addition of Grignard reagents or organolithium reagents to the SO 2 -surrogate DABSO generates a diverse set of metal sulfinates, which can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums to give sulfone products. (organic-chemistry.org)
  • Synthesis of allylic sulfones through a photoinduced three-component reaction of aryl/alkyl halides, potassium metabisulfite, and allylic bromides under ultraviolet irradiation at room temperature is developed. (rsc.org)
  • Multisubstituted vinyl sulfones were easily prepared with excellent alkyl group tolerance. (rsc.org)
  • Cyclic imides such as N-substituted alkyl ethers, thioethers, sulfoxides, sulfones and related derivatives were potent agents against human single cell tumors and selected solid tumor growths, eg adenocarcinoma of the colon and glloma. (ovid.com)
  • For example, a solvent can include a sulfone compound of R1--SO2--R2, with R1 being an alkyl group and R2 a partially oxygenated alkyl group, to exhibit high chemical and thermal stability and high oxidation resistance. (energy.gov)
  • The sulfone has a formula of R1--SO2--R2, wherein R1 is a linear or branched alkyl or partially or fully fluorinated linear or branched alkyl group having 1 to 7 carbon atoms, and R2 is a linear or branched or partially or fully fluorinated linear or branched oxygen containing alkyl group having 1 to 7 carbon atoms. (energy.gov)
  • We report the crystal structures of three major parasite cysteine proteases, cruzain, falcipain-3, and the first reported structure of rhodesain, in complex with a class of potent, small molecule, cysteine protease inhibitors, the vinyl sulfones. (nih.gov)
  • To overcome this challenge, we explored the abilities of β-lactamase inhibitors of the C-2- and C-3-substituted penicillin and cephalosporin sulfone families against OXA-1, extended-spectrum (OXA-10, OXA-14, and OXA-17), and carbapenemase-type (OXA-24/40) class D β-lactamases. (asm.org)
  • Previous studies showed that peptidyl vinyl sulfone inhibitors of falcipain-2 blocked the development of P. falciparum in culture and exerted antimalarial effects in vivo. (edu.mx)
  • We now report the structure-activity relationships for inhibition of falcipain-2, falcipain-3, and parasite development by 39 new vinyl sulfone, vinyl sulfonate ester, and vinyl sulfonamide cysteine protease inhibitors. (edu.mx)
  • U.S. is a considerable producer of sulfone polymer in the region. (openpr.com)
  • 4. The method of claim 3 wherein between about 1 and about 20 percent of the sulfone units in the polymer contain pendant sulfonate moieties. (google.es)
  • 2. The activated polymer of claim 1 wherein said at least one active sulfone moiety comprises a sulfone group having at least two carbon atoms and having a reactive site located at the second carbon from the sulfone group. (freepatentsonline.com)
  • 3. The activated polymer of claim 2 wherein said at least one active sulfone moiety is selected from the group consisting of vinyl sulfone, active ethyl sulfone, active derivatives of vinyl sulfone and ethyl sulfone, and combinations thereof. (freepatentsonline.com)
  • 9. The activated polymer of claim 8 wherein said substantially straight chain polymer is not substantially substituted beyond the active sulfone moieties. (freepatentsonline.com)
  • The aerospace industry has also witnessed a shift from the use of metals to the use of composite materials involving sulfone polymer which provides the products lighter weight and high strength. (verifiedmarketresearch.com)
  • The industry is expected to expand at a significant pace in the forecast period promising a healthy sulfone polymers market till 2024. (openpr.com)
  • Global Sulfone Polymers Market size is anticipated to grow at a healthy rate during the forecast period. (openpr.com)
  • North America is anticipated to remain a dominant region in the global sulfone polymers market in the forecast timeframe. (openpr.com)
  • The recent study by Fact.MR on 4,4-Dichlorodiphenyl sulfone (DCDPS) market offers a 10-year forecast between 2019 and 2029. (bccresearch.com)
  • The study also provides dynamics that are responsible for influencing the future status of the 4,4-Dichlorodiphenyl sulfone (DCDPS) market over the forecast period. (bccresearch.com)
  • A comprehensive estimate on 4,4-Dichlorodiphenyl sulfone (DCDPS) market has been provided through an optimistic as well as a conservative scenario, taking into account the sales of 4,4-Dichlorodiphenyl sulfone (DCDPS) during the forecast period. (bccresearch.com)
  • These chapters include the regional macros (political economic, and business environment outlook), which are expected to have a momentous influence on the growth of 4,4-Dichlorodiphenyl sulfone (DCDPS) market during the forecast period. (bccresearch.com)
  • Country-specific valuation on demand for 4,4-Dichlorodiphenyl sulfone (DCDPS) has been offered for each regional market, along with the market scope estimate and forecast, price index, and impact analysis of dynamics of prominence in regions and countries. (bccresearch.com)
  • Consequentially, this has further impelled the commercialization potential of the overall sulfone polymers industry which has been forecast to register a y-o-y CAGR of 6% over 2017-2024, as per reliable estimates. (fractovia.org)
  • Global Fluoromethyl phenyl sulfone Market Report 2019 - Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Fluoromethyl phenyl sulfone industry. (360marketupdates.com)
  • Electrical & electronics industry is expected to boost sulfone polymers market between 2017 and 2024. (openpr.com)
  • Sulfone polymers market to derive commendable proceeds from aerospace sector over 2017-2024, capacit. (fractovia.org)
  • The worldwide market for Sulfone Polymers is expected to grow at a CAGR of roughly 0.9% over the next five years, will reach 310 million US$ in 2023, from 290 million US$ in 2017, according to a new GIR (Global Info Research) study. (reportsnreports.com)
  • The report, titled Global Sulfone Polymers Industry 2017 is a methodical research study based on the Sulfone Polymers market, analyzing the competitive framework of the industry in the world. (aperturegames.com)
  • The objective of the experiments reported here was to investigate the chemopreventive activity of sulindac sulfone against mammary carcinogenesis and to study its mechanism. (aacrjournals.org)
  • Both sulindac sulfide and the sulfone inhibit the growth of cultured tumor cells, although the cellular mechanism(s) responsible for the antineoplastic activity of sulindac derivatives is unknown. (aacrjournals.org)
  • These data suggest that apoptosis is responsible for the cell growth inhibitory activity of sulindac sulfide and sulfone and represents a potential mechanism for the antineoplastic activity of these drugs. (aacrjournals.org)
  • Vinyl sulfones as antiparasitic agents and a structural basis for drug design. (nih.gov)
  • These data, in conjunction with comparative inhibition kinetics, provide insight into the molecular mechanisms that drive cysteine protease inhibition by vinyl sulfones, the binding specificity of these important proteases and the potential of vinyl sulfones as antiparasitic drugs. (nih.gov)
  • A new class of polyalkylene oxide vinyl sulfone reagents is described. (google.com)
  • hi, i am painting with vinyl sulfone dye on cotton (70%) t shirts, whare some shades are deep and light colors also, after setting in home made steamer for 30 min whare the tempareture is always 90 to 98 c. but the deep colos like navy blue or higher going duller as they washout. (jacquardproducts.com)
  • The reaction of alkenes with sodium arene sulfinates in the presence of potassium iodide and sodium periodate and a catalytic amount of acetic acid provides vinyl sulfones at room temperature. (organic-chemistry.org)
  • sulfone, phenyl vinyl manufacturers and suppliers with contacts and product range are mentioned in the study. (marketpublishers.com)
  • Furthermore, sulfone, phenyl vinyl prices in regional markets can be found in the report with regards to countries and companies. (marketpublishers.com)
  • The report also focuses on sulfone, phenyl vinyl consumers by providing data on companies that use it. (marketpublishers.com)
  • Sulfone, phenyl vinyl (CAS 5535-48-8) Market Research Report 2018 contents were prepared and placed on the website in March, 2018. (marketpublishers.com)
  • Please note that Sulfone, phenyl vinyl (CAS 5535-48-8) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • We are a leading and reputed manufacturer and exporter of Vinyl Sulphone . (fibre2fashion.com)
  • Vinyl sulphone : For dying fibre and. (fibre2fashion.com)
  • Vinyl Sulphone Base of Bronner's acid (CAS 52218-35-6) Market Research Report 2018 aims at providing comprehensive data on vinyl sulphone base of bronner's acid market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • The report includes vinyl sulphone base of bronner's acid description, covers its application areas, manufacturing methods, patents. (marketpublishers.com)
  • It captures vinyl sulphone base of bronner's acid market trends, pays close attention to vinyl sulphone base of bronner's acid manufacturers and names suppliers. (marketpublishers.com)
  • Besides, the report provides vinyl sulphone base of bronner's acid prices in regional markets. (marketpublishers.com)
  • In addition to the above the report determines vinyl sulphone base of bronner's acid consumers. (marketpublishers.com)
  • Vinyl Sulphone Base of Bronner's acid (CAS 52218-35-6) Market Research Report 2018 contents were worked out and placed on the website in March, 2018. (marketpublishers.com)
  • Please note that Vinyl Sulphone Base of Bronner's acid (CAS 52218-35-6) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • Our results identify independent structural correlates of falcipain inhibition and antiparasitic activity and suggest that peptidyl vinyl sulfones have promise as antimalarial agents. (edu.mx)
  • Vinyl sulfone is a chemical used as a raw material in the manufacture of reactive dyes that are used majorly in textiles.Reactive dye is a common type of dying stuff used for dying cellulose fiber. (alliedmarketresearch.com)
  • Vinyl sulfones are widely used as intermediates is various organic syntheses.However, it is a severe polluting agent, and the future of vinyl sulfone depends on how the issues for a clean and green environment are handled. (alliedmarketresearch.com)
  • The global vinyl sulfone market has been severely affected by the outbreak of the COVID-19 pandemic all over the world. (alliedmarketresearch.com)
  • Owing to the economic slowdown that followed the pandemic, decreasehas been witnessed in disposable income of consumers, resulting in decrease in growth ofthe textile industry, which, in turn, has a significant impact on the vinyl sulfone market. (alliedmarketresearch.com)
  • The disruption in supply chain due to the restrictions on transportation has led to several challenges faced by the vinyl sulfone manufacturers for procuring the raw materials, which led to lowering of production rate, thereby affecting the global market. (alliedmarketresearch.com)
  • Owing to extensive use in dye manufacturing, vinyl sulfone manufacturers are increasing their production capacity for the textile industry. (alliedmarketresearch.com)
  • Ubiquitin-Vinyl Sulfone is a potent and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic Vinyl Sulfone group. (southbaybio.com)
  • Ub-Vinyl Sulfone can be used for activity profiling experiments and DUB inhibitor specificity determination. (southbaybio.com)
  • We recommend an initial Recombinant Human Ubiquitin-Vinyl Sulfone concentration of 1-5 μM. (southbaybio.com)
  • This product consists of a full-length human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a c-terminal warhead (Vinyl Sulfone). (southbaybio.com)
  • UCHL3 (SBB-DE0023) activity with Ubiquitin-AMC (SBB-PS0043) measured in the presence of 12.5 nM and 0.1 nM Ubiquitin Vinyl Sulfone. (southbaybio.com)
  • It is used in different forms in medical industry such as polyarylsulphones (PSU) and polyether sulfone (PESU). (openpr.com)
  • Sulfones have been prepared by nucleophilic displacement of halides by sulfinates: ArSO2Na + Ar'Cl → Ar(Ar')SO2 + NaCl Sulfone is a relatively inert functional group, being weakly basic (compared to sulfoxides). (wikipedia.org)
  • are named "sulfoxides" and "sulfones", respectively. (acdlabs.com)
  • Sulfones are typically prepared by organic oxidation of thioethers, often referred to as sulfides. (wikipedia.org)
  • Modafinil sulfone is also a metabolite of armodafinil, the (R)-(-)-enantiomer of modafinil, as oxidation to the sulfone removes the chiral center at the sulfur atom. (wikipedia.org)
  • The present invention relates to a procedure for the purification of crude tetrabromobisphenol sulfone (hereinafter referred to as "tetrabromobisphenol S") by using solvent extraction, rather than recrystallization. (google.com)
  • At the anode, a LiF-rich interphase generated by early-onset reduction of the salt anion effectively suppresses solvent co-intercalation and subsequent graphite exfoliation, enabling unprecedented and highly reversible graphite cycling in a pure sulfone system. (materialstoday.com)
  • For another example, a battery can include, between an anode and a cathode, an electrolyte which includes ionic electrolyte salts and a non-aqueous electrolyte solvent which includes a non-symmetrical, non-cyclic sulfone. (energy.gov)
  • Trifluoromethyl-substituted fluorinated sulfones proved to be a promising next-generation electrolyte, as evidenced by the long-term cycling performance in an NMC532/graphite cell cycled at 4.6 V. Our future research will be focused on further tailoring the graphite/electrolyte interface by appropriate additives or co-solvent and scrutinizing the mechanism of the superior cell performance at high voltages. (chargedevs.com)
  • Modafinil sulfone (code name CRL-41056) is an achiral, oxidized metabolite of modafinil, a wakefulness-promoting agent. (wikipedia.org)
  • Modafinil sulfone is also a metabolite of the modafinil prodrug, adrafinil. (wikipedia.org)
  • Aldicarb sulfone is a groundwater contaminant and a neurotoxic metabolite of the insecticide aldicarb used on agricultural crops. (ewg.org)
  • Omeprazole-13C,D3 Sulfone is a labelled metabolite of Omeprazole, which is a proton pump inhibitor used in the treatment of dyspepsia. (bocsci.com)
  • In a one-pot synthesis of optically active β-hydroxy sulfones, intermediate β-keto sulfones obtained via a nucleophilic substitution reaction of α-bromoketones and sodium sulfinates were reduced through Ru-catalyzed asymmetric transfer hydrogenation using HCOONa as a hydrogen source. (organic-chemistry.org)
  • Owing to the escalating demand for lightweight aircraft components, sulfone polymers, polyethersulfone in particular, have found extensive popularity across the aviation domain in the recent years. (fractovia.org)
  • There are three types of sulfone polymers that are commercially available, they are polysulfone (PSU), polyethersulfone (PESU), and polyfenylsulfone (PPSU). (verifiedmarketresearch.com)
  • To create this new class of electrolytes, the team synthesized trifluoromethyl ethyl sulfone (FMES) and trifluoromethyl propyl sulfone (FMPS), which exhibit properties such as reduced viscosity, enhanced wetting and decreased boiling point compared with their non-fluorinated counterparts EMS and MIS. (chargedevs.com)
  • A one-pot synthesis of aryl sulfones from primary alcohols is described. (organic-chemistry.org)
  • Alcohols were treated with N -bromosuccinimide and triphenylphosphine, followed by addition of sodium arenesulfinate with a catalytic amount of tetrabutylammonium iodide to afford the aryl sulfones in good to high yields. (organic-chemistry.org)
  • An iron-catalyzed sulfonylation of aryl enol acetates with sulfonyl hydrazides enables the construction of β-keto sulfones under aerobic conditions. (organic-chemistry.org)
  • This procedure allowed the introduction of two sulfonic acid units on electron-deficient aryl rings in ortho positions to each sulfone bridge of the PSUs. (lu.se)
  • In the Ramberg-Bäcklund reaction and the Julia olefination, sulfones are converted to alkenes by the elimination of sulfur dioxide. (wikipedia.org)
  • A sulfone is a molecule that has a sulfur atom with bonds to two oxygen atoms. (wikipedia.org)
  • and sulfur dioxide (SO 2 ) is the best source of sulfur and sulfone functional group. (cea.fr)
  • An N-acyl-L-alpha-amino acid that is N-acetylmethionine where the sulfur is oxidised to the corresponding sulfone. (zfin.org)
  • With the development of Chinese sulfone polymers production technology, their share in the global market is increasing, and competitiveness in the global market gradually increases. (reportsnreports.com)
  • Major companies in sulfone polymers market are Solvay Corporation, Sumitomo Corporation, PolyOne Corporation, BASF SE, Solvay, and Jiangmen Youju New Materials Co., Ltd. Amongst these Sumitomo, BASF and Solvay are the major producers of Japan, Europe and U.S. respectively. (openpr.com)
  • Solvay Advanced Polymers says it has completed construction of a world-scale sulfone polymers plant at Marietta, OH. (chemweek.com)
  • In yet another instance, the renowned chemical firm Solvay has recently announced to expand its global production capacity of sulfone polymers. (fractovia.org)
  • Moreover, Solvay is currently constructing a new production facility in India and has announced to expand its operations in the U.S. As a consequence of such encouraging growth strategies being adopted by established companies, the sulfone polymers industry share would observe a marked uptick across Asian and North American regions in the times to come, cite analysts. (fractovia.org)
  • At present, the major manufacturers of sulfone polymers are concentrated in Europe (BASF) and USA (Solvay). (reportsnreports.com)
  • Manufacturers from USA (Solvay), EU (BASF) and Japan (Sumitomo Chemical) are the major leaders in the international market of sulfone polymers. (reportsnreports.com)
  • A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1- O -phosphono moiety and three different substituents at C-2 has been prepared. (beilstein-journals.org)
  • A combination of o -iodoxybenzoic acid and iodine mediates a direct synthesis of β-keto sulfones from alkenes and arenesulfinates in good yields in a one-pot reaction. (organic-chemistry.org)
  • This report focuses on the Sulfone Polymers in global market, especially in North America, Europe and Asia-Pacific, South America, Middle East and Africa. (reportsnreports.com)
  • The findings that both the prodrug and the sulfone inhibited carcinogenesis in vivo and nodule formation in organ culture and that the sulfone lacks inhibitory activity on prostaglandin synthesis suggest a mechanism(s) of chemoprevention that is independent of the prostaglandin pathway. (aacrjournals.org)
  • Recent studies, however, have shown that a sulfone derivative of sulindac, which essentially lacks prostaglandin synthesis inhibitory activity, also inhibits chemical carcinogenesis, suggesting that reduction of prostaglandin levels is not necessary for the antineoplastic activity of this class of drugs. (aacrjournals.org)
  • The global market size of Fluoromethyl phenyl sulfone is $XX million in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million by the end of 2024 with a CAGR of XX% from 2019 to 2024. (360marketupdates.com)
  • A sulfone is a chemical compound containing a sulfonyl functional group attached to two carbon atoms. (wikipedia.org)
  • Sulfones are prepared under conditions used for Friedel-Crafts reactions using sources of RSO+ 2 derived from sulfonyl halides and sulfonic acid anhydrides. (wikipedia.org)
  • Ethyl glyoxylate N -tosylhydrazone is an excellent sulfonyl anion surrogate in a DBU-catalyzed conjugate addition reaction with enones and enals for the synthesis of functionalized sulfones. (organic-chemistry.org)
  • In this study, we investigated the effects of sulindac sulfide and sulfone on the proliferation, differentiation, and apoptosis of HT-29 human colon carcinoma cells. (aacrjournals.org)
  • Sulindac sulfide and sulfone significantly reduced cell number in both preconfluent and confluent cultures of HT-29 cells with the sulfide showing approximately 4-fold greater potency. (aacrjournals.org)
  • Neither sulindac sulfide nor sulfone inhibited cell proliferation under conditions where the drugs were growth inhibitory. (aacrjournals.org)
  • Only under specific conditions involving mitogenic stimulation did sulindac sulfide and sulfone cause cell cycle arrest. (aacrjournals.org)
  • Neither sulindac sulfide nor the sulfone induced differentiation of HT-29 cells, but both drugs strongly induced apoptosis. (aacrjournals.org)
  • The apoptotic response to sulindac sulfide and sulfone was both time- and dose-dependent and involved a mechanism independent of their inhibitory effect on cell cycle progression. (aacrjournals.org)
  • Endorsed by an extensive end use spectrum, the revenue graph of sulfone polymers market is bound to witness a substantial upswing in the forthcoming years. (fractovia.org)
  • The crystallographic structure of the Enterobacter cloacae GC1 extended-spectrum class C beta-lactamase, inhibited by a new 7-alkylidenecephalosporin sulfone, has been determined by X-ray diffraction at 100 K to a resolution of 1.6 A. The crystal structure was solved by molecular replacement using the unliganded structure [Crichlow et al. (nih.gov)
  • The reaction provides γ-keto- and γ-hydroxy sulfones in a simple and reliable way through a sulfa-Michael reaction that proceeds with good yield and chemoselectivity. (organic-chemistry.org)
  • Cryoquenching of the reaction of the sulfone with the enzyme produced an intermediate that is covalently bound via Ser64. (nih.gov)
  • Arylatde pyrazoles, and bis(diaryl)sulfones were prepared by Suzuki-Miyuara reaction in very good yield.Di(alkenyl)pyridines and bipyridyls were prepared by Heck reaction.Bipyridyls were the unexpected products. (uni-rostock.de)
  • 5.The report estimates 2019-2024 market development trends of Fluoromethyl phenyl sulfone industry. (360marketupdates.com)
  • In an unprecedented oxidative radical process, dioxygen as the solely terminal oxidant triggers an aerobic oxidative difunctionalization of terminal alkynes toward β-keto sulfones with high selectivity. (organic-chemistry.org)
  • Global Sulfone Polymers Market has most applications in the medical industry. (openpr.com)
  • The Sulfone Polymers market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. (bharatbook.com)
  • The study analyzes crucial trends that are currently determining the growth of 4,4-Dichlorodiphenyl sulfone (DCDPS) market. (bccresearch.com)
  • This report explicates on vital dynamics such as the drivers, restraints and opportunities for key market players along with key stakeholders as well as emerging players associated with the manufacturing of 4,4-Dichlorodiphenyl sulfone (DCDPS). (bccresearch.com)
  • A list of prominent companies operating in the 4,4-Dichlorodiphenyl sulfone (DCDPS) market along with their product portfolio enhances the reliability of this comprehensive research study. (bccresearch.com)
  • The study offers a comprehensive analysis on diverse features including production capacities, demand, product developments, revenue generation and sales in 4,4-Dichlorodiphenyl sulfone (DCDPS) market across the globe. (bccresearch.com)
  • 4,4-Dichlorodiphenyl sulfone (DCDPS) market has been analyzed for each market segment, in terms of volume (Kilo tons) and value (US$ Mn). (bccresearch.com)
  • Market estimates at global and regional levels for 4,4-Dichlorodiphenyl sulfone (DCDPS) is available in terms of "US$ Mn" for value and in "Kilo tons" for volume. (bccresearch.com)
  • A Y-o-Y growth contrast on prominent 4,4-Dichlorodiphenyl sulfone (DCDPS) market segments, along with market attractiveness evaluation has been incorporated in the report. (bccresearch.com)
  • Absolute dollar opportunity plays a crucial role in assessing the level of opportunity that a manufacturer/distributor can look to achieve along with identifying potential resources, considering sales and distribution perspective in the global 4,4-Dichlorodiphenyl sulfone (DCDPS) market. (bccresearch.com)
  • Essential and up-to-date data information related to the market performers, who are principally engaged in the production of the 4,4-Dichlorodiphenyl sulfone (DCDPS), has been brought with the help of a detailed dashboard view. (bccresearch.com)
  • Speaking of the strategic landscape, some of the prominent firms operating in sulfone polymers market have been making concerted efforts to expand their product manufacturing capacity over the recent years. (fractovia.org)
  • With an objective to strengthen its competitive position in the ever-evolving sulfone polymers market, the Belgium based company is slated to raise the manufacturing capacity of its high-performance thermoplastic material by more than 35% over the next five years of duration. (fractovia.org)
  • In consequence, the launch of such advanced products would have a positive influence on sulfone polymers market share from the aerospace vertical. (fractovia.org)
  • With polymers being utilized abundantly across a plethora of mainstream industries such as automotive, electrical & electronics, consumer goods, medical, and aerospace, the meteoric rise of sulfone polymers market is sure to persist in the ensuing years. (fractovia.org)
  • The latest report on Sulfone Polymers market envelops all critical aspects of this domain such as predominant trends and driving forces to guide businesses, stakeholders, and marketers in taking better decisions. (fractovia.org)
  • The research report on Sulfone Polymers market delivers a comprehensive analysis of the past and current business scenario to infer the industry's trajectory over 2019-2025. (fractovia.org)
  • According to this study, over the next five years the Sulfone Polymers market will register a 0.9%% CAGR in terms of revenue, the global market size will reach $ 301.1 million by 2025, from $ 290.2 million in 2019. (fractovia.org)
  • Globally, the sulfone polymers market is mainly driven by growing demand for automotive industry and electronics industry. (reportsnreports.com)
  • There are 15 Chapters to deeply display the global Sulfone Polymers market. (reportsnreports.com)
  • Using efficient analytical tools such as SWOT analysis and Porter's five forces analysis, the report provides a comprehensive assessment of the Sulfone Polymers market. (aperturegames.com)
  • The report estimates the market size in terms of volume (kilo tons) and revenue (US$) produced, whereas, the key segments and the geographical subdivision of the Sulfone Polymers market are also analyzed in detail. (aperturegames.com)
  • The market drivers, limitations, and growth prospects of each segment are discussed in this report and, based on that, analysts have determined the future of the market for Sulfone Polymers in the global arena. (aperturegames.com)
  • The report covers each aspect of the market for Sulfone Polymers in globally, starting from the basic information about the market and advancing to the various criteria on the basis of which the market is classified. (aperturegames.com)
  • The major applications of the Sulfone Polymers market are also discussed in the report. (aperturegames.com)
  • The report studies the Sulfone Polymers market by evaluating the market chain, prevalent policies, and regulations as well as the manufacturers, their manufacturing chain, cost structures, and contribution in the industry. (aperturegames.com)
  • The regional markets for the global Sulfone Polymers market are examined by analyzing the pricing of products in the region compared to the profit generated. (aperturegames.com)
  • The company profiles of the major participants operating in the global Sulfone Polymers market have been reviewed in this study. (aperturegames.com)
  • 1.The report provides key statistics on the market status of the Fluoromethyl phenyl sulfone manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. (360marketupdates.com)
  • Sulfone Polymers Market was valued at USD 1040.85 Million in 2020 and is projected to reach USD 1672.21 Million by 2028 , growing at a CAGR of 6.11% from 2021 to 2028 . (verifiedmarketresearch.com)
  • The growth of the Sulfone Polymers Market can be credited to the numerous chemically favorable properties of sulfone polymers, and the growth of various industries such as aerospace and automotive, medical and consumer appliances, and Food and Beverages. (verifiedmarketresearch.com)
  • The Global Sulfone Polymers Market report provides a holistic evaluation of the market. (verifiedmarketresearch.com)
  • One of the primary growth drivers of the global Sulfone Polymers Market is the growth of various end-use industries, namely, the aerospace, automotive, consumer appliances, and healthcare industry. (verifiedmarketresearch.com)
  • Sulfone polymers have a variety of applications across a range of different materials belonging to these industries, and hence the growth of these industries seemingly contributes to the growth of the market. (verifiedmarketresearch.com)
  • This also contributes to the growth of the Sulfone Polymers Market. (verifiedmarketresearch.com)
  • Modification of the most active compound, adamantaneacetyl-(6-aminohexanoyl)3-(leucyl)3-vinylmethyl-sulphone itself capable of proteasome inhibition in living cells, afforded a new set of radio- and affinity labels. (enzolifesciences.com)
  • Building upon our previous structural studies that examined tazobactam trapped as a trans-enamine intermediate in a deacylation deficient SHV variant, we designed a novel penam sulfone derivative that forms a more stable trans-enamine intermediate. (rcsb.org)
  • This mild transformation in an aqueous medium provides chiral β-hydroxy sulfones with high yields and excellent enantioselectivities. (organic-chemistry.org)
  • For these systems, facile hydroxide displacement of the sulfone linkage was found to occur exclusively on the more electrophilic ring to give the novel benzophenone-2'-hydroxy-2-sulfinic acids. (caltech.edu)
  • Examples of sulfones in pharmacology include dapsone, a drug formerly used as an antibiotic to treat leprosy, dermatitis herpetiformis, tuberculosis, or pneumocystis pneumonia (PCP). (wikipedia.org)