Chemicals and DrugsPhenomena and Processes
Sulfhydryl CompoundsTioproninbeta-Aminoethyl IsothioureaCysteamineDithiothreitolMercaptoethanolCysteineGlutathioneHydrogen-Ion ConcentrationOxidation-ReductionKineticsEthylmaleimideDithionitrobenzoic AcidChloromercuribenzoatesDisulfidesIodoacetamideMercuribenzoatesp-Chloromercuribenzoic Acid
Sulfhydryl Compounds
Compounds containing the -SH radical.
Tiopronin
Sulfhydryl acylated derivative of GLYCINE.
beta-Aminoethyl Isothiourea
A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.
Cysteamine
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.
Dithiothreitol
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
Mercaptoethanol
Cysteine
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Hydrogen-Ion Concentration
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Kinetics
The rate dynamics in chemical or physical systems.
Ethylmaleimide
A sulfhydryl reagent that is widely used in experimental biochemical studies.
Dithionitrobenzoic Acid
A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.
Chloromercuribenzoates
Chloride and mercury-containing derivatives of benzoic acid.
Disulfides
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
Iodoacetamide
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
Mercuribenzoates
Mercury-containing benzoic acid derivatives.
p-Chloromercuribenzoic Acid
An organic mercurial used as a sulfhydryl reagent.

Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (1/4324)

The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties.  (+info)

Sulfhydryl compounds in melanocytes of yellow (Ay/a), nonagouti (a/a), and agouti (A/A) mice. (2/4324)

CLEFFMANN (1953, 1963a,b) has reported that yellow but not black melanocytes of agouti (A/A) rabbits contained reducing sulfhydryl compounds. We have attempted to repeat CLEFFMANN's observations in mouse melanocytes of the lethal yellow (Ay/a), nonagouti (a/a) and agouti (A/A) genotypes. Our results contradict those of CLEFFMANN and reveal that yellow and black melanocytes, regardless of genotype, possess equivalent amounts of histochemically detectable sulfhydryl compounds. These results do not support the hypothesis that agouti-locus genes act by controlling the sulfhydryl metabolism of pigment cells.  (+info)

Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II. (3/4324)

Myeloperoxidase (MPO) is the most abundant protein in neutrophils and plays a central role in microbial killing and inflammatory tissue damage. Because most of the non-steroidal anti-inflammatory drugs and other drugs contain a thiol group, it is necessary to understand how these substrates are oxidized by MPO. We have performed transient kinetic measurements to study the oxidation of 14 aliphatic and aromatic mono- and dithiols by the MPO intermediates, Compound I (k3) and Compound II (k4), using sequential mixing stopped-flow techniques. The one-electron reduction of Compound I by aromatic thiols (e.g. methimidazole, 2-mercaptopurine and 6-mercaptopurine) varied by less than a factor of seven (between 1.39 +/- 0.12 x 10(5) M(-1) s(-1) and 9.16 +/- 1.63 x 10(5) M(-1) s(-1)), whereas reduction by aliphatic thiols was demonstrated to depend on their overall net charge and hydrophobic character and not on the percentage of thiol deprotonation or redox potential. Cysteamine, cysteine methyl ester, cysteine ethyl ester and alpha-lipoic acid showed k3 values comparable to aromatic thiols, whereas a free carboxy group (e.g. cysteine, N-acetylcysteine, glutathione) diminished k3 dramatically. The one-electron reduction of Compound II was far more constrained by the nature of the substrate. Reduction by methimidazole, 2-mercaptopurine and 6-mercaptopurine showed second-order rate constants (k4) of 1.33 +/- 0.08 x 10(5) M(-1) s(-1), 5.25 +/- 0.07 x 10(5) M(-1) s(-1) and 3.03 +/- 0.07 x 10(3) M(-1) s(-1). Even at high concentrations cysteine, penicillamine and glutathione could not reduce Compound II, whereas cysteamine (4.27 +/- 0.05 x 10(3) M(-1) s(-1)), cysteine methyl ester (8.14 +/- 0.08 x 10(3) M(-1) s(-1)), cysteine ethyl ester (3.76 +/- 0.17 x 10(3) M(-1) s(-1)) and alpha-lipoic acid (4.78 +/- 0.07 x 10(4) M(-1) s(-1)) were demonstrated to reduce Compound II and thus could be expected to be oxidized by MPO without co-substrates.  (+info)

Thiol-dependent degradation of protoporphyrin IX by plant peroxidases. (4/4324)

Protoporphyrin IX (PP) is the last porphyrin intermediate in common between heme and chlorophyll biosynthesis. This pigment normally does not accumulate in plants because its highly photodynamic nature makes it toxic. While the steps leading to heme and chlorophylls are well characterized, relatively little is known of the metabolic fate of excess PP in plants. We have discovered that plant peroxidases can rapidly degrade this pigment in the presence of thiol-containing substrates such as glutathione and cysteine. This thiol-dependent degradation of PP by horseradish peroxidase consumes oxygen and is inhibited by ascorbic acid.  (+info)

Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes. (5/4324)

Selenium has been increasingly recognized as an essential element in biology and medicine. Its biochemistry resembles that of sulfur, yet differs from it by virtue of both redox potentials and stabilities of its oxidation states. Selenium can substitute for the more ubiquitous sulfur of cysteine and as such plays an important role in more than a dozen selenoproteins. We have chosen to examine zinc-sulfur centers as possible targets of selenium redox biochemistry. Selenium compounds release zinc from zinc/thiolate-coordination environments, thereby affecting the cellular thiol redox state and the distribution of zinc and likely of other metal ions. Aromatic selenium compounds are excellent spectroscopic probes of the otherwise relatively unstable functional selenium groups. Zinc-coordinated thiolates, e.g., metallothionein (MT), and uncoordinated thiolates, e.g., glutathione, react with benzeneseleninic acid (oxidation state +2), benzeneselenenyl chloride (oxidation state 0) and selenocystamine (oxidation state -1). Benzeneseleninic acid and benzeneselenenyl chloride react very rapidly with MT and titrate substoichiometrically and with a 1:1 stoichiometry, respectively. Selenium compounds also catalyze the release of zinc from MT in peroxidation and thiol/disulfide-interchange reactions. The selenoenzyme glutathione peroxidase catalytically oxidizes MT and releases zinc in the presence of t-butyl hydroperoxide, suggesting that this type of redox chemistry may be employed in biology for the control of metal metabolism. Moreover, selenium compounds are likely targets for zinc/thiolate coordination centers in vivo, because the reactions are only partially suppressed by excess glutathione. This specificity and the potential to undergo catalytic reactions at low concentrations suggests that zinc release is a significant aspect of the therapeutic antioxidant actions of selenium compounds in antiinflammatory and anticarcinogenic agents.  (+info)

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (6/4324)

The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan.  (+info)

Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. (7/4324)

4-Hydroxy-2-nonenal (HNE) is a major lipid peroxidation product formed during oxidative stress. Because of its reactivity with nucleophilic compounds, particularly metabolites and proteins containing thiol groups, HNE is cytotoxic. The aim of this study was to assess the extent and time course for the formation of HNE-modified proteins during ischemia and ischemia plus reperfusion in isolated rat hearts. With an antibody to HNE-Cys/His/Lys and densitometry of Western blots, we quantified the amount of HNE-protein adduct in the heart. By taking biopsies from single hearts (n = 5) at various times (0, 5, 10, 15, 20, 35, and 40 min) after onset of zero-flow global ischemia, we showed a progressive, time-dependent increase (which peaked after 30 min) in HNE-mediated modification of a discrete number of proteins. In studies with individual hearts (n = 4/group), control aerobic perfusion (70 min) resulted in a very low level (296 arbitrary units) of HNE-protein adduct formation; by contrast, after 30-min ischemia HNE-adduct content increased by >50-fold (15,356 units, P < 0.05). In other studies (n = 4/group), administration of N-(2-mercaptopropionyl)glycine (MPG, 1 mM) to the heart for 5 min immediately before 30-min ischemia reduced HNE-protein adduct formation during ischemia by approximately 75%. In studies (n = 4/group) that included reperfusion of hearts after 5, 10, 15, or 30 min of ischemia, there was no further increase in the extent of HNE-protein adduct formation over that seen with ischemia alone. Similarly, in experiments with MPG, reperfusion did not significantly influence the tissue content of HNE-protein adduct. Western immunoblot results were confirmed in studies using in situ immunofluorescent localization of HNE-protein in cryosections. In conclusion, ischemia causes a major increase in HNE-protein adduct that would be expected to reflect a toxic sequence of events that might act to compromise tissue survival during ischemia and recovery on reperfusion.  (+info)

Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress. (8/4324)

The irreversible oxidation of cysteine residues can be prevented by protein S-thiolation, in which protein -SH groups form mixed disulfides with low-molecular-weight thiols such as glutathione. We report here the identification of glyceraldehyde-3-phosphate dehydrogenase as the major target of protein S-thiolation following treatment with hydrogen peroxide in the yeast Saccharomyces cerevisiae. Our studies reveal that this process is tightly regulated, since, surprisingly, despite a high degree of sequence homology (98% similarity and 96% identity), the Tdh3 but not the Tdh2 isoenzyme was S-thiolated. The glyceraldehyde-3-phosphate dehydrogenase enzyme activity of both the Tdh2 and Tdh3 isoenzymes was decreased following exposure to H2O2, but only Tdh3 activity was restored within a 2-h recovery period. This indicates that the inhibition of the S-thiolated Tdh3 polypeptide was readily reversible. Moreover, mutants lacking TDH3 were sensitive to a challenge with a lethal dose of H2O2, indicating that the S-thiolated Tdh3 polypeptide is required for survival during conditions of oxidative stress. In contrast, a requirement for the nonthiolated Tdh2 polypeptide was found during exposure to continuous low levels of oxidants, conditions where the Tdh3 polypeptide would be S-thiolated and hence inactivated. We propose a model in which both enzymes are required during conditions of oxidative stress but play complementary roles depending on their ability to undergo S-thiolation.  (+info)

Patent US7840903 - Group content representations - Google PatentsPatent US7840903 - Group content representations - Google Patents
A system and method are provided for representing content made accessible by a group of users. In general, a group content representation that is descriptive of content made accessible by the group of users is presented to an interested user. In one embodiment, the users are represented by avatars in a virtual environment, and the group content representation is presented in a view of the virtual environment provided to the interested user. The group content representation may be presented at a fixed or dynamic location within the virtual environment. For example, the group content representation may be presented at a location relative to the avatars representing the group of users in the virtual environment. Based on the group content representation, the interested user is enabled to quickly and easily determine whether content of interest is accessible from the group of users.
http://www.google.com/patents/US7840903?dq=6101531
Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation |...Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation |...
In this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p < 0.001), and disulfide/total thiol (p < 0.001) were determined higher, while native thiol (p = 0.004) and total thiol (p < 0.001) levels were much lower. In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, ...
https://avesis.aybu.edu.tr/yayin/aa2e1b7e-cbad-4434-99fc-6f6a1a898b71/determination-of-thiol-disulphide-homeostasis-in-type-1-diabetes-mellitus-and-the-factors-associated-with-thiol-oxidation
Total Thiols: Biomedical Importance And Their Alteration In Various Disorders - CogprintsTotal Thiols: Biomedical Importance And Their Alteration In Various Disorders - Cogprints
Thiols are the organic compounds that contain a sulphydryl group. Among all the antioxidants that are available in the body, thiols constitute the major portion of the total body antioxidants and they play a significant role in defense against reactive oxygen species. Total thiols composed of both intracellular and extracellular thiols either in the free form as oxidized or reduced glutathione, or thiols bound to proteins. Among the thiols that are bound to proteins, albumin makes the major portion of the protein bound thiols, which binds to sufhydryl group at its cysteine-34 portion. Apart from their role in defense against free radicals, thiols share significant role in detoxification, signal transduction, apoptosis and various other functions at molecular level. The thiol status in the body can be assessed easily by determining the serum levels of thiols. Decreased levels of thiols has been noted in various medical disorders including chronic renal failure and other disorders related to ...
http://cogprints.org/6664/
Selective purification of the thiol peptides of myosin - MySci...Selective purification of the thiol peptides of myosin - MySci...
Selective purification of the thiol peptides of myosin: 1. A method for selective purification of thiol peptides is described. Thiol groups in a protein are tre
https://www.mysciencework.com/publication/show/selective-purification-of-the-thiol-peptides-of-myosin
Increase in T cell surface thiol levels are linked with activation and diabetogenicity | The Journal of ImmunologyIncrease in T cell surface thiol levels are linked with activation and diabetogenicity | The Journal of Immunology
Free radicals contribute to Type 1 diabetes (T1D) autoimmune responses. We recently demonstrated that superoxide-deficient CD4 T cells exhibited increased effector responses and diabetogenicity, but the redox-dependent mechanism(s) mediating T cell activation were unclear. We hypothesized that during T1D progression, CD4 T cells with a reduced cell surface state would exhibit a concomitant increase in pro-inflammatory cytokine and chemokine responses. To test this, alexa fluor 647-conjugated maleimide (ALM)-labeling of cell surface reduced thiols on diabetogenic mouse and human CD4 T cells was performed. We observed an increase in ALM percentage and gMFI from peripheral Non-obese diabetic (NOD) mouse CD4 T cells during progression to overt diabetes. Cognate autoantigen stimulation elicited a 2- and 20-fold increase in CD4 ALM T cell percentage and gMFI, respectively. In addition to serving as a T cell activation marker, ALM gMFI of reduced CD4 T cell surface thiols was enhanced (1.2-fold) with ...
http://www.jimmunol.org/content/198/1_Supplement/58.10
Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein | CirculationPassive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein | Circulation
Acute exposure of a nonsmoking subject to passive smoking resulted in deterioration of serum antioxidant defense, accelerated lipid peroxidation, and accumulation of LDL cholesterol in cultured human macrophages. These events were observed even after a very short period (30 minutes) of passive smoking. Indeed, it has previously been suggested that the cardiovascular system is extremely sensitive to the chemicals in environmental tobacco smoke.1 Furthermore, the oxidative stress induced by SHS may have a more prominent effect on a nonsmoking subject than on an active smoker whose cardiovascular system has adapted to CS.1 Oxidative stress induced by acute passive smoking significantly decreased plasma ascorbic acid and caused a minor, nonsignificant decrease in protein sulfhydryl groups, reflecting increased use of these antioxidants. This is in line with previous studies demonstrating that long-term exposure to SHS decreases plasma ascorbic acid in both active and passive smokers.7 12 ...
http://circ.ahajournals.org/content/97/20/2012
OPUS 4 | Thiol-redox proteomics of Mycobacterium smegmatis in response to ROS, RNS and antibioticsOPUS 4 | Thiol-redox proteomics of Mycobacterium smegmatis in response to ROS, RNS and antibiotics
Bacteria are exposed to oxidative stress as an unavoidable consequence of their aerobic lifestyle. Reactive oxygen species (ROS) are generated in the stepwise one-electron reduction of molecular oxygen during the respiration. Pathogens encounter ROS during the oxidative burst of macrophages as part of the host immune defense. Besides ROS, bacteria also have to cope with reactive chlorine, electrophilic and nitrogen species (RCS, RES, RNS). To cope with these reactive species, bacteria have evolved different defense and repair mechanisms. To maintain the reduced state of the cytoplasm, they utilize low molecular weight (LMW) thiols. LMW thiols are small thiol-containing compounds that can undergo post-translational thiolmodifications with protein thiols, termed as S-thiolations. S-thiolations function as major redox regulatory and thiol-protection mechanism under oxidative stress conditions. In eukaryotes and Gram-negative bacteria, the tripeptide glutathione (GSH) functions as major LMW thiol, which is
https://epub.ub.uni-greifswald.de/frontdoor/index/index/searchtype/simple/query/%2A%3A%2A/browsing/true/rows/100/facetNumber_author_facet/all/languagefq/eng/start/2/institutefq/Institut+f%C3%BCr+Mikrobiologie+-+Abteilung+f%C3%BCr+Genetik+%26+Biochemie/docId/2525
Electroanalytical adaptation of the classical Ellmans assay: Determination of total thiols in incubation media from a...
The total thiols in a medium containing authentic biological sample (articular cartilage) has been determined electrochemically. The detection strategy utilises the electrochemical adaptation of the Ellmans reaction process via the electrochemically initiated reaction of thiols with diethyl-p-phenylenediamine. The strategy has been examined over a biologically significant pH range and the behaviour observed rationalised. The detection of thiols within the biological sample is shown to proceed with micromolar levels of thiol determined within the sample.
https://www.dpag.ox.ac.uk/publications/38568
Turkish Neurosurgery
The tissue thiol levels of HGGs were found to be higher than the control group (p = 0.001). Although the median thiol levels of Grade 4 gliomas were higher than those of Grade 3, no statistically significant difference was noted (p = 0.076). When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001). The thiol levels of Grade 4 IDH1- gliomas were statistically significantly higher than of Grade 3 gliomas (p = 0.023), but no statistically significant difference between the thiol levels of Grade 3 and Grade 4 IDH1+ tumors was noted (p = 0.459 ...
http://www.turkishneurosurgery.org.tr/summary_en_doi.php?doi=10.5137/1019-5149.JTN.31866-20.2
Sulfhydryl Compounds
Contact: Eastsong. Phone: +86 15621028051. E-mail: [email protected] Whatsapp:+86 15621028051. Add: No.276, Zhangkou Road, Qingdao, China. ...
https://www.eastsongco.com/Sulfhydryl-Compounds.html
Sodium Nitroprusside: Mechanism of NO Release Mediated by Sulfhydryl-Containing MoleculesSodium Nitroprusside: Mechanism of NO Release Mediated by Sulfhydryl-Containing Molecules
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_jm049857n
Asian Science Citation Index - Articles written by M.L. BatariAsian Science Citation Index - Articles written by M.L. Batari
Background and Objective: Blood contains low concentration of thiols and some (thiols) are found in the albumin compartment. So far, little or no information exists on the relationship between serum total thiols and albumin in sub-chronic lead intoxication. To examine the relationship between serum total thiols and albumin in sub-chronic lead intoxicated rats supplemented with folic acid and/or vitamin C. Materials and Methods: This study was performed using 40 male albino rats weighing 160-190 g. The albino rats were divided into eight 8 of five each. Group 1-4 were sub-chronically intoxicated with lead fora period of 6 weeks, followed by supplementation with folic acid and/or vitamin C to group 2-7 fora period of 4 weeks. After the 10th week, the experimental rats were fasted overnight and sacrificed, after which their blood samples were collected. Results: Findings from this study revealed statistically significant (p,0.05) decrease in serum total thiols and albumin concentration in the ...
https://scialert.net/asci/author.php?ascicat=ALL&author=M.L.&last=Batari
Are we getting enough sulfur in our diet? | Nutrition & Metabolism | Full TextAre we getting enough sulfur in our diet? | Nutrition & Metabolism | Full Text
Glutathione (GSH)is the most abundant low molecular weight thiol and form of storage of SH-. Animal and human studies have demonstrated that adequate protein nutrition is crucial for the maintenance of GSH homeostasis [48]. Elevated levels of GSH inhibit prostaglandin production by a direct interaction with COX enzymes, of potential significance in the progression of inflammatory or degenerative states [36]. It is of particular interest, as discussed earlier that prostagandins synthesized from PUFA and most of the non-steroidal anti-inflammatory drugs share this same locus of involvement. It is also relevant that some recent studies have found that on occasions the pain reduction in OA associated with the administration of chondroitin sulfate, a source of sulfur, was found to be equivalent to that provided by NSAID. The reasons for such unpredictable results, we suspect could be associated with differences in levels of protein in the diet, the better responders consuming higher amounts of SAA. ...
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-4-24/
This groups content is available only to members - Los Angeles/Orange County Shiba Inu Meetup Group (Long Beach, CA) |...This groups content is available only to members - Los Angeles/Orange County Shiba Inu Meetup Group (Long Beach, CA) |...
Come join fellow Shibas and their servants/owners for playdates with other local Shibas. Many of our members have great Shiba stories, and many tips on how to deal with our very strong-minded dogs. We
https://www.meetup.com/LA-OCShibaInu/members/52247012/
This groups content is available only to members - Los Angeles/Orange County Shiba Inu Meetup Group (Long Beach, CA) |...This groups content is available only to members - Los Angeles/Orange County Shiba Inu Meetup Group (Long Beach, CA) |...
Come join fellow Shibas and their servants/owners for playdates with other local Shibas. Many of our members have great Shiba stories, and many tips on how to deal with our very strong-minded dogs. We
https://www.meetup.com/LA-OCShibaInu/members/8781443/
A Comparison Between Two Assays for the Redox Status in Plasma | OMICS InternationalA Comparison Between Two Assays for the Redox Status in Plasma | OMICS International
In the present study, two commercial assays for the redox status are compared and evaluated, the SH groups in proteins (SHp) and the total thiol levels (TTL). Both assa..
https://www.omicsonline.org/open-access/a-comparison-between-two-assays-for-the-redox-status-in-plasma-2155-9872-1000342.php?aid=85241
Engineering Disulfide Cross‐Links in RNA Using Thiol‐Disulfide Interchange Chemistry - Current ProtocolsEngineering Disulfide Cross‐Links in RNA Using Thiol‐Disulfide Interchange Chemistry - Current Protocols
Protocols for postsynthetic modification of 2‐amino‐containing oligoribonucleotides with either an alkyl‐phenyl disulfide or an alkyl thiol group are described
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-nc0501.html
Investigating the Role of Thiol Modifications in Developing the Preeclampsia Phenotype - Discovery - the University of...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
https://discovery.dundee.ac.uk/en/projects/investigating-the-role-of-thiol-modifications-in-developing-the-p
Tert-Dodecyl Mercaptan Sales Market 2016 : Global Market Analysis, Share, Regional Outlook, Forecast.Acute Market Reports
The global Tert-Dodecyl Mercaptan market was about 304 Million USD in 2015 and is expected to grow at a CAGR of 5.39% from 2017 to 2022. The global sales of
http://www.rundirectmagazine.com/tert-dodecyl-mercaptan-sales-market-2016-global-market-analysis-share-regional-outlook-forecast-acute-market-reports/16150/
Maleimide Coated 96 Well Solid Plates | BiomatMaleimide Coated 96 Well Solid Plates | Biomat
Maleimide Coated 96 Well Solid Plates offer a powerful instrument for binding biomolecules containing free sulfhydryl groups or reducibile disulfide bonds.
https://www.biomat.it/product/96-well-plates/maleimide-coated-96-well-solid-plates/
Reactions of N-tricyanovinylamines with thiols in aqueous solutions - [scite report]Reactions of N-tricyanovinylamines with thiols in aqueous solutions - [scite report]
Kinetics of reactions between N-substituted tricyanovinylamines and thiols, where primarily reduction of the C=C double bond takes place, was investigated under conditions adequate to physiological ones. The reaction rates did not depend either on the type of the reacting thiol, or on the pH of the medium, but they decreased with the increasing pKa value of the imino group. A quantitative conversion of the thiol peptide glutathione to its oxidized form was evidenced.
https://scite.ai/reports/reactions-of-n-tricyanovinylamines-with-thiols-mrkx4X
Balancing pump efficiency with NPSH is the key to delivering a cost effective package Pump LibraryBalancing pump efficiency with NPSH is the key to delivering a cost effective package Pump Library
Amarinth pump manufacuring UK document Library presents Balancing pump efficiency with NPSH is the key to delivering a cost effective package
https://www.amarinth.com/library/balancing-pump-efficiency-with-npsh-is-the-key-to-delivering-a-cost-effective-package/
FAM226A (family with sequence similarity 226 member A (non-protein coding))FAM226A (family with sequence similarity 226 member A (non-protein coding))
FAM226A (family with sequence similarity 226 member A (non-protein coding)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_FAM226A.html
MegaExams - Test Smarter | Questions
Q 8. A compound with molecular mass 180 is acylated with {tex} \mathrm { CH } _ { 3 } \mathrm { COCl } {/tex} to get a compound with molecular mass {tex} 390 . {/tex} The number of amino groups present per molecule of the former compound is: ...
https://megaexams.com/questions/JEE-Main/Organic-Compounds-Containing-Nitrogen/
ɑ-Methoxy-ω-maleinimides
For sulfhydryl-selective coupling of PEG to proteins and other thiol substrates and for selective scavenging of thiol containing peptides. ...
http://www.rapp-polymere.com/index.php?id=1203¤cy=usd
Gentaur Molecular :Biovis \ SH-6 \ 1819-500Gentaur Molecular :Biovis \ SH-6 \ 1819-500
Gentaur molecular products has all kinds of products like :search , Biovis \ SH-6 \ 1819-500 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=1772587&supplier=search&name=SH_6
The stability of the 105[Rh(16S4diol)Cl2]+ radiopharmaceutical precursor in solutions containing human plasma thiols in:...The stability of the 105[Rh(16S4diol)Cl2]+ radiopharmaceutical precursor in solutions containing human plasma thiols in:...
105Rh[1,5,9,13-tetrathiacyclohexadecane-3,11-diol] is a promising drug precursor for targeted radiotherapy. Nevertheless, the axial position of chloride ions in the complex structure and their weak binding to rhodium centre, due to HSAB concept, make such a complex subject to modifying action of certain sulphuric ligands, like human plasma thiol antioxidants: glutathione and cysteine. Experiments were performed with both radioactive 105Rh and inactive rhodium. The complexation of rhodium with 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16S4diol) resulted in three distinct peaks seen on UV, radiometric and MS chromatograms. The substitution of chlorides was noted in over 80% of 105[Rh(16S4diol)Cl2]+ units after incubation with glutathione, and less than 10% of complex units after incubation with cysteine (24 h, 37 °C). Reaction of 105[Rh(16S4diol)Cl2]+ with 1,8-octandithiol and 1,9-nonandithiol resulted in disappearance of the complex peak and occurrence of two new peaks. Product of RhCl3 and ...
https://akjournals.com/abstract/journals/10967/285/2/article-p293.xml?rskey=G9u2Vh&result=5
Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups...
Fingerprint Dive into the research topics of Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide. Together they form a unique fingerprint. ...
https://koreauniv.pure.elsevier.com/en/publications/induction-of-the-mitochondrial-permeability-transition-by-seleniu/fingerprints/
Cancers | Free Full-Text | Studies on the Non-Protein Thiols of a Human Prostatic Cancer Cell Line: Glutathione Content | HTMLCancers | Free Full-Text | Studies on the Non-Protein Thiols of a Human Prostatic Cancer Cell Line: Glutathione Content | HTML
The low molecular weight thiol (-SH) content of a human prostate carcinoma cell line (LNCap), important to the cellular resistance to drugs and irradiation, was investigated using three forms of thiol assay each utilizing different chemistries. The composition of the mixture was examined by derivatization of the thiols with a three-fold excess of the Ellman reagent to give mixed aromatic disulfides. The components were isolated by chromatography on C18 reverse phase silica gel followed by DE52 anion exchange separation, and then analyzed by capillary electrophoresis against prepared standards. The glutathione adduct (GSSE) and an unknown disulfide (RSSE) were the major components isolated on DE52 together with two minor ones. However, from the absorbance at 325 nm, it was found that the GSSE isolated (1.5 ± 0.2 femtomoles/cell) could only account for 28.5 ± 4.3% of the total ASF thiols. It appeared that the bulk of the thiol material had not formed a stable mixed disulfide with Ellmans reagent, and
http://www.mdpi.com/2072-6694/2/2/1092/htm
Ellmans reagent - WikipediaEllmans reagent - Wikipedia
This reaction is rapid and stoichiometric, with the addition of one mole of thiol releasing one mole of TNB. The TNB2− is quantified in a spectrophotometer by measuring the absorbance of visible light at 412 nm, using an extinction coefficient of 14,150 M−1 cm−1 for dilute buffer solutions,[3][4] and a coefficient of 13,700 M−1 cm−1 for high salt concentrations, such as 6 M guanidinium hydrochloride or 8 M urea.[4] Unfortunately the extinction coefficient for dilute solutions was underestimated in the original 1959 publication, as 13,600 M−1 cm−1, and as noted in a recent article, this mistake has persisted in the literature.[5] Commercial DTNB may not be completely pure, so may require recrystallization to obtain completely accurate and reproducible results.[4]. Ellmans reagent can be used for measuring low-molecular mass thiols such as glutathione in both pure solutions and biological samples, such as blood.[6] It can also measure the number of thiol groups on ...
https://en.m.wikipedia.org/wiki/Ellman%27s_reagent
GB1479501A - Method and catalyst for removing mercaptans and mercaptide compounds from aqueous alkaline solutions -...
1479501 Oxidizing mercaptans ASHLAND OIL Inc 1 Aug 1974 [7 Sept 1973] 34069/74 Heading C2C [Also in Divisions B1 and C5] Mercaptans and mercaptides are oxidized to the disulphides in aqueous alkaline solution in the presence of catalysts comprising a causticinert carrier impregnated with a tetrapyridinoporphyrazine or a tetrapyrazinoporphyrazine of the formula in which M is Cu, Ag, Mg, Zn, Hg, Th, Ti, Hf, Sn, Pb, V, Nb, Ta, Sb, Bi, Cr, Mo, Mn, Fe, Co, Ni, Pd or Pt, each R is H, alkyl, aralkyl or aryl or two adjacent R groups are constituents of a cyclic carbon structure, and X is =N- or = CR-. Examples describe the oxidation of nbutyl mercaptan in aqueous sodium hydroxide using air as oxidant and activated carbon impregnated with cobalt or vanadium tetrapyridinoporphyrazine as catalyst.
https://patents.google.com/patent/GB1479501A/en
Ethylene Mercaptan, China Ethylene Mercaptan, Ethylene Mercaptan exporters, China Ethylene Mercaptan Suppliers - Eastar Chemical
We, China Ethylene Mercaptan Manufacturers, China Ethylene Mercaptan Suppliers, provide quality Ethylene Mercaptan product and the products related with China Ethylene Mercaptan - Eastar Chemical
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Der Mechanismus der Photoadduktbildung in LOV-Domänen - University of Regensburg Publication ServerDer Mechanismus der Photoadduktbildung in LOV-Domänen - University of Regensburg Publication Server
Attempts to denature the surrounding protein scaffold, i. e. to isolate the photoadduct consisting of FMN and methyl mercaptan failed. The adduct is apparently very unstable. For this reason, it was impossible to identify the adduct via mass spectrometry. However the structure of the adduct could be confirmed by CD spectroscopy. Irradiation of free FMN in aqueous solution in the presence of methyl mercaptan did not yield the corresponding free adduct of FMN and methyl mercaptan, but the fully reduced hydroquinone form of FMN. Therefore, the protein scaffold carries out two different functions: It guides the photoreaction between FMN and methyl mercaptan to adduct formation and it stabilizes the photoadduct after its formation ...
https://epub.uni-regensburg.de/13428/
Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in...
TY - JOUR. T1 - Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS. T2 - Implications in excitotoxicity. AU - Diwakar, Latha. AU - Kenchappa, Rajappa S.. AU - Annepu, Jayasree. AU - Ravindranath, Vijayalakshmi. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/7. Y1 - 2007/7. N2 - Oxidative stress, excitotoxicity and mitochondrial dysfunction play synergistic roles in neurodegeneration. Maintenance of thiol homeostasis is important for normal mitochondrial function and dysregulation of protein thiol homeostasis by oxidative stress leads to mitochondrial dysfunction and neurodegeneration. We examined the critical roles played by the antioxidant, non-protein thiol, glutathione and related enzyme, glutaredoxin in maintaining mitochondrial function during excitotoxicity caused by β-N-oxalyl amino-l-alanine (l-BOAA), the causative factor of neurolathyrism, a motor neuron disease involving the pyramidal system. ...
https://mayoclinic.pure.elsevier.com/en/publications/downregulation-of-glutaredoxin-but-not-glutathione-loss-leads-to-
Publication : USDA ARSPublication : USDA ARS
Citation: N/A Interpretive Summary: Technical Abstract: In tomato, impaired reductive activation of the stromal bisphosphatases appears to be the dominating factor limiting carbon assimilation following chilling in the light. The illumination-dependent activation of at least seven different chloroplast enzymes involves the reversible thiol/disulfide exchange between thioredoxin and the photosynthetic enzyme. The thermodynamics of the thiol/disulfide exchange between thioredoxin and the regulatory sulfhydryl groups of the various light-regulated chloroplast enzymes explains the differential responses among the various thioredoxin-regulated enzymes to the effects of chilling in the light (Hutchison et al. 2000). In the case of dark chilling, an intriguing effect of low temperature on the circadian regulation of transcription indicates that the low-temperature induced inhibition of photosynthesis in tomato may result from the loss of coordination in the expression of critical enzymes controlling ...
https://www.ars.usda.gov/research/publications/publication/?seqNo115=113221
Mechanism of photoprotection of wool with formaldehyde and thiol derivatives - DROMechanism of photoprotection of wool with formaldehyde and thiol derivatives - DRO
Millington, Keith R, Maurdev, George and Jones, Michael J 2009, Mechanism of photoprotection of wool with formaldehyde and thiol derivatives, Coloration technology, vol. 125, no. 2, pp. 117-122, doi: 10.1111/j.1478-4408.2009.00183.x. ...
http://dro.deakin.edu.au/view/DU:30095243
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against...
TY - JOUR. T1 - Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. AU - Dinkova-Kostova, Albena T.. AU - Holtzclaw, W. David. AU - Cole, Robert N.. AU - Itoh, Ken. AU - Wakabayashi, Nobunao. AU - Katoh, Yasutake. AU - Yamamoto, Masayuki. AU - Talalay, Paul. N1 - dc.publisher: National Academy of Sciences The first author designed and performed the experiments, and wrote the paper. The work was the first demonstration that inducers of cytoprotective responses are initially sensed in a chemical reaction with highly reactive sulfhydryl groups of the sensor protein Keap1. This finding has opened the field for many other investigators. dc.description.sponsorship: Lewis B. and Dorothy Cullman Foundation Barbara Lubin Goldsmith Foundation McMullan Family Fund National Cancer Institute Department of Health and Human Services CA 94076 American Institute for Cancer Research (Washington, DC) PY - ...
https://discovery.dundee.ac.uk/en/publications/direct-evidence-that-sulfhydryl-groups-of-keap1-are-the-sensors-r
Investigations into the loss of glutathione from lenses in organ culture<...
TY - JOUR. T1 - Investigations into the loss of glutathione from lenses in organ culture. AU - Qin, Chuan. AU - Tumminia, Santa J.. AU - Russell, Paul. AU - Rao, P. Vasantha. AU - Zigler, J. Samuel. PY - 1996. Y1 - 1996. N2 - Purpose. To investigate possible causes and implications of the decrease in glutathione concentration in rat lenses during organ culture. Methods. Freshly excised lenses were incubated in modified TC-199 medium. Ellmans Reagent or the GSH-400 assay were used to assay glutathione levels in lenses cultured for different times and under a variety of altered culture conditions. Results. In lenses from young rats the glutathione decrease was not ameliorated by reduction of oxygen tension in the incubator, nor by supplementation of the culture medium with various antioxidants or sulfhydryl compounds, nor with the amino acid precursors of glutathione. Addition of 2-mercaptoethanol stimulated cysteine transport into the lens but had only a modest effect in maintaining the level of ...
https://jhu.pure.elsevier.com/en/publications/investigations-into-the-loss-of-glutathione-from-lenses-in-organ--3
OPUS Würzburg | SearchOPUS Würzburg | Search
Cysteines play important roles in the biochemistry of many proteins. The high reactivity, redox properties, and ability of the free thiol group to coordinate metal ions designate cysteines as the amino acids of choice to form key catalytic components of many enzymes. Also, cysteines readily react with reactive oxygen and nitrogen species to form reversible oxidative thiol modifications. Over the last few years, an increasing number of proteins have been identified that use redox-mediated thiol modifications to modulate their function, activity, or localization. These redox-regulated proteins are central players in numerous important cellular processes. First aim of this study was to discover nitric oxide (NO) sensitive proteins in E. coli, whose redox-mediated functional changes might explain the physiological alterations observed in E. coli cells suffering from NO-stress. To identify E. coli proteins that undergo reversible thiol modifications upon NO-treatment in vivo, I applied a differential ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/all/rows/20/facetNumber_subject/all/institutefq/Theodor-Boveri-Institut+f%C3%BCr+Biowissenschaften/start/0/subjectfq/Chronologisches+Altern
Thiol Oxidative Stress Induced by Metabolic Disorders Amplifies Macrophage Chemotactic Responses and Accelerates Atherogenesis...Thiol Oxidative Stress Induced by Metabolic Disorders Amplifies Macrophage Chemotactic Responses and Accelerates Atherogenesis...
In this study we examined whether metabolic stress induced by hypercholesterolemia alone or hyperlipidemia plus hyperglycemia accelerates atherosclerosis and renal injury by promoting thiol oxidative stress in macrophages and increasing the recruitment of macrophages to sites of tissue injury. We found that with each additional level of metabolic stress, macrophage accumulation increased in both atherosclerotic lesions and in kidneys of LDL-R−/− mice. Analysis of the macrophage glutathione reduction potential (Eh) revealed that metabolic stress promotes intracellular thiol oxidation and that oxidation of the macrophage glutathione reduction state correlates with both accelerated macrophage recruitment and increased lesion severity. Macrophage recruitment into MCP-1-loaded Matrigel plugs implanted in these mice was also accelerated with each additional level of metabolic stress, suggesting that increased cellular thiol oxidation induced by metabolic stress amplifies macrophage responses to ...
http://atvb.ahajournals.org/content/29/11/1779
CiNii 論文 - Oxidative Stress : Induced Increase in Intracellular Ca^|2+| and Ca^|2+| : Induced...
In order to study the oxidative stress-induced change in intracellular concentration of Ca,SUP,2+,/SUP, ([Ca,SUP,2+,/SUP,]i) and Ca,SUP,2+,/SUP,-induced oxidative stress, effects of hydrogen peroxide and ionomycin, a calcium ionophore, on rat cerebellar neurons were examined using a flow cytometer and fluorescent dyes: fluo-3 for monitoring [Ca,SUP,2+,/SUP,]i; 2, 7-dichlorofluorescin, for reactive oxygen species; and 5-chloromethylfiuorescein, for cellular nonprotein thiols. Oxidative stress induced by hydrogen peroxide dose-dependently increased [Ca,SUP,2+,/SUP,]i and decreased the content of nonprotein thiols. Ionomycin increased oxidative metabolism and decreased the content of nonprotein thiols. Results suggest that oxidative stress induces an increase in [Ca,SUP,2+,/SUP,]j While an increase in [Ca,SUP,2+,/SUP,]i increases oxidative stress in neurons.. ...
https://ci.nii.ac.jp/naid/10008676670
Plus itPlus it
Although the biophysical properties of T-channels were first described in sensory neurons (Carbone and Lux, 1984), their function in nociception has only recently been established (Todorovic et al., 2001a; Bourinet et al., 2005; Choi et al., 2007). Indeed, the molecular mechanisms that regulate the function of these channels in pain processing still are not well understood. The major finding of this study is that LA inhibits native and recombinant T-currents by oxidizing specific thiol residues on the extracellular face of the channel. Inhibition of CaV3.2 T-channels and the ensuing decrease in cellular excitability in nociceptive DRG cells may contribute to the documented analgesic properties of LA in vivo. This notion is strongly supported by the finding that local intraplantar injection of LA potently diminished responses to noxious thermal and mechanical stimuli in wild-type mice, but was completely ineffective in CaV3.2 knock-out mice. Importantly, we identified a novel regulatory site on ...
http://www.jneurosci.org/content/29/30/9500
OPUS 4 | SearchOPUS 4 | Search
Thiol or sulfhydryl groups are highly reactive functional groups in cellular systems. Molecules carrying thiol groups are mostly derivatives of the amino acid cysteine and are grouped as low molecular weight (LMW)-thiols: coenzyme A (CoA), glutathione (GSH) or bacillithiol (BSH). LMW-thiols can help in the maintenance of the reduced cellular environment as so called redox-buffers. Additionally, they act as co-factors in enzyme reactions or help in the detoxification of reactive oxygen or nitrogen species, electrophilic compounds or thiophilic metalloids (arsenite, tellurite). In proteins from different organisms cysteine is underrepresented compared to other amino acids, but still overtakes diverse roles. It is an important determinant in the tertiary and quaternary structure of proteins. The nucleophilic character of the thiol or thiolate group, respectively, makes cysteine the catalytically active amino acids of different enzymes. As a precursor cysteine participates in the formation of Fe-S ...
https://epub.ub.uni-greifswald.de/solrsearch/index/search/searchtype/simple/query/%2A%3A%2A/browsing/true/yearfq/2012/rows/50/facetNumber_subject/all/start/0/sortfield/year/sortorder/desc/subjectfq/Proteom
HyStem Hydrogel Stiffness Variation Protocol for a 12.5 mL Kit - ESI BIOHyStem Hydrogel Stiffness Variation Protocol for a 12.5 mL Kit - ESI BIO
This protocol describes how to vary the stiffness of a hydrogel made with a 12.5 mL HyStem® Hydrogel Kit, which is composed of Glycosil (CMHA-S, thiol-modified hyaluronic acid), Gelin-S (Gtn-DTPH, thiol-modified gelatin), Extralink (PEGDA, polyethylene glycol diacrylate), and DG Water (degassed, deionized water).
http://www.esibio.com/support/product-documentation/protocols/hystem-hydrogel-stiffness-variation-protocol-12-5-kit
Protocol: HyStem Hydrogel Stiffness Variations for 7.5 mL KitProtocol: HyStem Hydrogel Stiffness Variations for 7.5 mL Kit
This protocol describes how to vary the stiffness of a hydrogel made with a 7.5 mL HyStem® Hydrogel Kit, which is composed of Glycosil® (CMHA-S, thiol-modified hyaluronic acid), Gelin-S® (Gtn-DTPH, thiol-modified gelatin), Extralink® (PEGDA, polyethylene glycol diacrylate), and DG Water (degassed, deionized water).
http://www.esibio.com/index.php/support/product-documentation/protocols/hystem-hydrogel-stiffness-variation-protocol/?mode=list
Thiol Redox Transitions in Cell Signaling, Part A, Volume 473 - 1st EditionThiol Redox Transitions in Cell Signaling, Part A, Volume 473 - 1st Edition
Purchase Thiol Redox Transitions in Cell Signaling, Part A, Volume 473 - 1st Edition. Print Book & E-Book. ISBN 9780123813459, 9780123813466
https://www.elsevier.com/books/thiol-redox-transitions-in-cell-signaling-part-a/cadenas/978-0-12-381345-9
Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis - Research Explorer : Aston UniversityStabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis - Research Explorer : Aston University
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., ...
https://research.aston.ac.uk/portal/en/researchoutput/stabilising-cysteinyl-thiol-oxidation-and-nitrosation-for-proteomic-analysis
Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals<...Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals<...
TY - JOUR. T1 - Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals. AU - Nakashima, Izumi. AU - Pu, Mei Yi. AU - Nishizaki, Akira. AU - Rosila, Idris. AU - Ma, Li. AU - Katano, Yoshiaki. AU - Ohkusu, Kozo. AU - Rahman, S. M.Jamshedur. AU - Isobe, Ken Ichi. AU - Hamaguchi, Michinari. AU - Saga, Keisuke. PY - 1994/2/1. Y1 - 1994/2/1. N2 - Cross-linking with specific ligand is a general requirement for ordered activation of cell surface receptors. In this study we demonstrated a novel pathway for disregulated receptor activation through a redox mechanism. Treatment of murine thymocytes or spleen cells with thiol-reactive HgCl2, a known inducer of autoimmune proliferative lymphocyte disorders in rodents, was found to induce tyrosine phosphorylation of several cellular proteins, which was up to 100 times as extensive as that triggered by stimulation with antireceptor antibody or mitogen. Through the cross-linkage by thiol-reactive ...
https://pure.fujita-hu.ac.jp/en/publications/redox-mechanism-as-alternative-to-ligand-binding-for-receptor-act
RasMol Assignment 2 - 4 There are 2 prosthetic groups present in HIV-1 Reverse Transcriptase 5 There are roughly 24...RasMol Assignment 2 - 4 There are 2 prosthetic groups present in HIV-1 Reverse Transcriptase 5 There are roughly 24...
View Notes - RasMol Assignment 2 from CHEM 101 at Northwestern IA. 4. There are 2 prosthetic groups present in HIV-1 Reverse Transcriptase. 5. There are roughly 24 phenylalanine present. 6. I looked
https://www.coursehero.com/file/6428647/RasMol-Assignment-2/
Bếp Điện Từ Canzy CZ-88NPSH InverterBếp Điện Từ Canzy CZ-88NPSH Inverter
Mua sản phẩm Bếp Điện Từ Canzy CZ-88NPSH Inverter giá rẻ tại Khalinguyen. Giao hàng nhanh. Hàng chính hãng nhập khẩu từ các thương hiệu nổi tiếng trên thị trường thiết bị vệ sinh và nhà bếp
https://khalinguyen.vn/thiet-bi-nha-bep/bep-dien-tu-canzy-cz-88npsh-inverter
Smoke em if youve got em - The BigBearButtSmoke em if youve got em - The BigBearButt
Ive been gallivanting through a gallimaufry of gaming goals recently, but this Bear cannot get it in gear from group content alone. There have to be soloing goals to grip me as well, yknow? At this point in the expansion lull, what do you do? Just keep scouting Archaeology sites to get those last nine rares?…
https://thebigbearbutt.com/2012/07/27/smoke-em-if-youve-got-em/?like_comment=64078&_wpnonce=fc0d4ebc1f
Smoke em if youve got em - The BigBearButtSmoke em if youve got em - The BigBearButt
Ive been gallivanting through a gallimaufry of gaming goals recently, but this Bear cannot get it in gear from group content alone. There have to be soloing goals to grip me as well, yknow? At this point in the expansion lull, what do you do? Just keep scouting Archaeology sites to get those last nine rares?…
https://thebigbearbutt.com/2012/07/27/smoke-em-if-youve-got-em/?like_comment=64079&_wpnonce=4f96d99374&replytocom=64084
Hospital discharge: the patient, carer and doctor perspective - PDFHospital discharge: the patient, carer and doctor perspective - PDF
Hospital discharge: the patient, carer and doctor perspective JANUARY 2014 BMA Patient Liaison Group Contents Foreword by Dr Mark Porter, Chair of Council, BMA...3 Foreword by Catherine Macadam, Chair
http://docplayer.net/1572011-Hospital-discharge-the-patient-carer-and-doctor-perspective.html
Nitrous Oxide Kit for 48cc/49cc and 66cc/80cc, with 5 refills (Free Sh | Gasbike.netNitrous Oxide Kit for 48cc/49cc and 66cc/80cc, with 5 refills (Free Sh | Gasbike.net
Nitrous Kit for 48cc/66cc/80cc 2 stroke engines, 49cc 4-stroke engines These nitrous kits are designed to mount directly to your handle bars so that you never h
https://www.gasbike.net/products/nitrous-oxide-kit-for-48cc-49cc-and-66cc-80cc-with-5-refills-free-shipping
Webpages of interest - SPP 1710 HomeWebpages of interest - SPP 1710 Home
RedoxDB. A database dedicated to oxidative thiol modifications. The database already includes more than 2,000 proteins for which oxidative modifications, such as disulfides, S-sulfenylation, S-sulfinylation, S-glutathionylation, and S-nitrosylation, have been reported.. ...
http://www.thiolswitches.de/datas/ofinterest/
Gastec Ethyl Mercaptan Detector Tube 0.2-75 ppm, 10/packGastec Ethyl Mercaptan Detector Tube 0.2-75 ppm, 10/pack
|p|Gastec Detector Tubes indicate concentrations directly by way of a calibrated scale printed on the tubes. Gastec detector tubes are used for analysing airborne gases/vapours, as well as pollutants in soil and water.|/p|
https://www.newstarenvironmental.com/gastec-acetaldehyde-detector-tube-5-750-ppm-10-pack-26400.html
FCUB - Jelena M. A imovi
I.D. Pavićević, V.B. Jovanović, M.M. Takić, A.Z. Penezić-Romanjuk, J.M. Aćimović, Lj.M. Mandić: Fatty acids binding to human serum albumin: changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal. Chem Biol Int (2014) 224, 42-50 ...
http://www.chem.bg.ac.rs/osoblje/67-en.html
SimTK: Dynamic Redox Regulation of IL-4 Signaling: PublicationsSimTK: Dynamic Redox Regulation of IL-4 Signaling: Publications
This paper provides a systems level integration of the molecular events subject to reversible oxidation during IL-4 signal transduction. Code for simulation provided.
https://simtk.org/plugins/publications/index.php?type=group&id=1044&pluginname=publications
Isosorbide mononitrateIsosorbide mononitrate
Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl ... Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a ...
https://en.wikipedia.org/wiki/Isosorbide_mononitrate
Neutron capture therapy of cancerNeutron capture therapy of cancer
Tumor-binding sulfhydryl boron compounds". Journal of Medicinal Chemistry. 10 (4): 714-7. doi:10.1021/jm00316a042. PMID 6037065 ... Second, gadolinium compounds, such as Gd-DTPA (gadopentetate dimeglumine Magnevist®), have been used routinely as contrast ... Ono K (August 2016). "An analysis of the structure of the compound biological effectiveness factor". Journal of Radiation ... 1 and a compound biological effectiveness (CBE) factor for BPA in skin of 2.5. A relative biological effectiveness (RBE) or CBE ...
https://en.wikipedia.org/wiki/Neutron_capture_therapy_of_cancer
Thiol S-methyltransferaseThiol S-methyltransferase
Bremer J; Greenberg DM (1961). "Enzymic methylation of foreign sulfhydryl compounds". Biochim. Biophys. Acta. 46 (2): 217-224. ...
https://en.wikipedia.org/wiki/Thiol_S-methyltransferase
TioproninTiopronin
Jaffe IA (March 1986). "Adverse effects profile of sulfhydryl compounds in man". The American Journal of Medicine. 80 (3): 471- ... which are broadly similar to those of D-penicillamine and other compounds containing active sulfhydryl groups. Its ... In 2016 Imprimis Pharmaceuticals introduced a lower cost version marketed as a compounded drug. It may also be used for ... Portal: Medicine (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical ...
https://en.wikipedia.org/wiki/Tiopronin
Thiosalicylic acidThiosalicylic acid
... is an organosulfur compound containing carboxyl and sulfhydryl functional groups. Its molecular formula is ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without InChI ...
https://en.wikipedia.org/wiki/Thiosalicylic_acid
Sulfate transporterSulfate transporter
"In vitro proteoglycan sulfation derived from sulfhydryl compounds in sulfate transporter chondrodysplasias". Pediatric ...
https://en.wikipedia.org/wiki/Sulfate_transporter
Johanna BudwigJohanna Budwig
Budwig believed sulphydryl compounds were important to cellular metabolism and cellular respiration. Budwig researched the ... theory that a low oxygen environment would develop in the absence of sulphydryl groups and/or fatty acid partners that would ... a researcher at the German Federal Health Office she noted many cancer drugs being evaluated in the 1950s contained sulphydryl ...
https://en.wikipedia.org/wiki/Johanna_Budwig
Cell cycleCell cycle
The pattern of resistance and sensitivity correlates with the level of sulfhydryl compounds in the cell. Sulfhydryls are ...
https://en.wikipedia.org/wiki/Cell_cycle
MPGES-2MPGES-2
The activity of PTGES2 is thought to be increased in the presence of sulfhydryl compounds, in particular dithiothreitol. The ...
https://en.wikipedia.org/wiki/MPGES-2
CinitaprideCinitapride
... prostaglandins and sulfhydryl compounds". Pharmacology. 54 (4): 193-202. doi:10.1159/000139487. PMID 9211565. Alarcón de la ...
https://en.wikipedia.org/wiki/Cinitapride
MerallurideMeralluride
Kunin, Calvin A. (September 10, 1976). "Effect of organic mercurials and sulfhydryl compounds on the urease activity of Proteus ... Studies in the late 1970s showed the compound had antimicrobial effect against Proteus bacteria responsible for urinary tract ... Studies from Japan showed the compound caused ventricular fibrillation in a high percentage of animals when compared to ...
https://en.wikipedia.org/wiki/Meralluride
2-Iminothiolane2-Iminothiolane
... reacts with primary amines efficiently at pH 7 to 9, creating amidine compounds with a sulfhydryl group. Thus ... It is a thiolating reagent that reacts with primary amine groups, such as those of amino acids, to form sulfhydryl groups. ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with ... 2-Iminothiolane is a cyclic thioimidate compound also known as Traut's reagent. ...
https://en.wikipedia.org/wiki/2-Iminothiolane
IproniazidIproniazid
... did not deplete sulfhydryl-group containing compounds. The isopropyl radical formed as a result of the metabolism of iproniazid ... In contrast, the compounds cobalt chloride, piperonyl butoxide and alpha-naphthylisothiocyanate inhibit microsomal enzymes ... Alkylating agents have the capability to bind to chemical groups such as amino, phosphate hydroxyl, imidazole and sulfhydryl ... Rat models and other animal models have shown that cytochrome P450 enzymes convert isopropyl hydrazine to alkylating compounds ...
https://en.wikipedia.org/wiki/Iproniazid
MesnaMesna
... is an organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the ... Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing ... Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. Mesna is a water-soluble ... This conjugation reaction inactivates the urotoxic compounds to harmless metabolites. The metabolites are then excreted in the ...
https://en.wikipedia.org/wiki/Mesna
Louis RapkineLouis Rapkine
He pursued biochemical research on the metabolic and developmental roles of sulfhydryl compounds, working initially with ... Rapkine, L. (1938). "Sulfhydryl groups and enzymic oxido-reduction". Biochemical Journal. 32 (10): 1729-1739. doi:10.1042/ ...
https://en.wikipedia.org/wiki/Louis_Rapkine
Margaret Kelly (pharmacologist)Margaret Kelly (pharmacologist)
Her studies with laboratory animals showed that sulfhydryl compounds may protect against toxicity from x-irradiation and ... alkylating agents by a distribution pattern which causes more of a protective compound to accumulate in the sensitive tissues ...
https://en.wikipedia.org/wiki/Margaret_Kelly_(pharmacologist)
MethacrylonitrileMethacrylonitrile
For example, via epoxide hydratase (EH) or via interactions with a sulfhydryl compound, which leads to the formation of a ... Methacrylonitrile (or 2-Methylprop-2-enenitrile), MeAN in short, is a chemical compound that is an unsaturated aliphatic ... "unsaturated compounds formed by a burning cigarette. Anal. Proc. 21, 135 Farooqui, M. Y. H. and M. M. Mumtaz (1991). " ...
https://en.wikipedia.org/wiki/Methacrylonitrile
AcetylcholineAcetylcholine
Organic mercurial compounds, such as methylmercury, have a high affinity for sulfhydryl groups, which causes dysfunction of the ... In 1926, Loewi and E. Navratil deduced that the compound is probably acetylcholine, as vagusstoff and synthetic acetylcholine ... Acetylcholine is synthesized in certain neurons by the enzyme choline acetyltransferase from the compounds choline and acetyl- ... muscarine is a compound found in the mushroom Amanita muscaria; nicotine is found in tobacco. Nicotinic acetylcholine receptors ...
https://en.wikipedia.org/wiki/Acetylcholine
MoexiprilMoexipril
A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types". Journal of Medicinal Chemistry. 29 ( ... and is metabolized in the liver to form the pharmacologically active compound moexiprilat. Formation of moexiprilat is caused ... "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. ...
https://en.wikipedia.org/wiki/Moexipril
Branched-chain amino acid aminotransferaseBranched-chain amino acid aminotransferase
... sulfhydryl, or Cu2+ or Co2+ reagents/compounds Enzyme catalyzes reaction best with branched chain amino acids (in order from ... In Cucumis melo (melon), BCATs have been found to play a role in developing aroma volatile compounds that give melons their ... As fermentation proceeds, these α-ketoacids degrade into a class of compounds known as methyl-branched volatiles that include ... The branched-chain amino acid aminotransferases help to produce compounds like isovaleric acid, isobutyric acid, 2- and 3- ...
https://en.wikipedia.org/wiki/Branched-chain_amino_acid_aminotransferase
ThiophenolThiophenol
... s also describes a class of compounds formally derived from thiophenol itself. All have a sulfhydryl group (-SH) ... The prefix thio- implies a sulfur-containing compound and when used before a root word name for a compound which would normally ... Thiophenol is an organosulfur compound with the formula C6H5SH, sometimes abbreviated as PhSH. This foul-smelling colorless ... There are several methods of synthesis for thiophenol and related compounds, although thiophenol itself is usually purchased ...
https://en.wikipedia.org/wiki/Thiophenol
Arsenic biochemistryArsenic biochemistry
However, the monomethylated compound was shown to be more reactive and more toxic than the inorganic arsenic compounds to human ... Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively targeted by arsenite (III) metabolites. ... This compound is then converted to a mono-methylated arsenic (III) compound using Glutathione S-Transferase Omega-1 (GSTO1). ... Representative organoarsenic compounds found in nature. Arsenobetaine, one of the most common arsenic compound in nature. Also ...
https://en.wikipedia.org/wiki/Arsenic_biochemistry
Miguel OndettiMiguel Ondetti
He settled on using a sulfhydryl group which binds strongly to zinc. Ondetti had discovered Captopril, an ACE inhibitor with ... U.S. Patent 3,740,385 "N-Terminal Derivatives of Secretin", filed May 1970, issued June 1973 U.S. Patent 4,199,512 "Compounds ... "Compounds for alleviating angiotensin related hypertension", filed February 1978, issued July 1982 U.S. Patent 4,722,810 " ... His group tried thousands of compounds from the Squibb library, but none yielded satisfying results. After reading literature ...
https://en.wikipedia.org/wiki/Miguel_Ondetti
Glutathione S-transferaseGlutathione S-transferase
... of GSH-via a sulfhydryl group-to electrophilic centers on a wide variety of substrates in order to make the compounds more ... However, some endogenous compounds, e.g., bilirubin, can inhibit the activity of GSTs. In mammals, GST isoforms have cell ... The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, ... Because the GST protein has a strong binding affinity for GSH, beads coated with the compound can be added to the protein ...
https://en.wikipedia.org/wiki/Glutathione_S-transferase
BioprospectingBioprospecting
The mechanism of action of an isolated compound can also be misidentified if a single assay is used because some compounds ... For example, the sulfhydryl-scavenging assay used to detect histone acetyltransferase inhibition can give a false positive ... to include reference compounds (ie. pure chemical compounds for which accurate bioactivity and toxicity data are available), to ... Using just a single assay, especially a single in vitro assay, gives a very incomplete picture of an extract or compound's ...
https://en.wikipedia.org/wiki/Bioprospecting
PropanethiolPropanethiol
... is an organic compound with the molecular formula C3H8S. It belongs to the group of thiols. It is a colorless ... except that sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group in the molecule. ... Propanethiol is chemically classified among the thiols, which are organic compounds with molecular formulas and structural ... 21, 1962, Preparation of Organic Sulfur Compounds (Webarchive template wayback links, Articles without InChI source, Articles ...
https://en.wikipedia.org/wiki/Propanethiol
ThiolThiol
The term sulfhydryl- or mercapto- is used as a prefix, e.g. mercaptopurine. Many thiols have strong odors resembling that of ... These compounds are detectable by the human nose at concentrations of only 10 parts per billion. Human sweat contains (R)/(S)-3 ... Sulfhydryl groups in the active site of an enzyme can form noncovalent bonds with the enzyme's substrate as well, contributing ... The −SH functional group itself is referred to as either a thiol group or a sulfhydryl group, or a sulfanyl group. Thiols are ...
https://en.wikipedia.org/wiki/Thiol
1-Butanethiol1-Butanethiol
... is a very noxious and caustic chemical compound, and at sufficiently high concentrations, it produces serious ... except that the sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group (-OH) in the molecule. 1 ... which are organic compounds with molecular formulas and structural formulas similar to alcohols, ...
https://en.wikipedia.org/wiki/1-Butanethiol
HelenalinHelenalin
The double bond in the carbonyl group can undergo a Michael addition with a thiol group, also called a sulfhydryl group. ... For this reason the compound or its derivatives may have potential medical applications. Helenalin belongs to the group of ... Depending on the dose of helenalin, thiol-bearing compounds such as glutathione may provide some protection to cells from ... Most of these derivatives occur naturally, such as the compound dihydrohelenalin, but there are also some semi-synthetic ...
https://en.wikipedia.org/wiki/Helenalin
Quantitative proteomicsQuantitative proteomics
... reactive iodacetyl function group which labels sulfhydryl-(-SH) groups (iodoTMT) and (3) reactive alkoxyamine functional group ... which provides covalent labeling of carbonyl-containing compounds (aminoxyTMT). A key benefit of isobaric labeling over other ...
https://en.wikipedia.org/wiki/Quantitative_proteomics
MolybdopterinMolybdopterin
InChI Key HPEUEJRPDGMIMY-UHFFFAOYSA-N Structure, synthesis, empirical formula for the di-sulfhydryl. Archived 2016-06-04 at the ... Webarchive template wayback links, CS1 maint: uses authors parameter, Chemical articles with multiple compound IDs, Multiple ... Lassner, Erik (1999). Tungsten: Properties, Chemistry, Technology of the Element, Alloys and Chemical Compounds. Springer. pp. ...
https://en.wikipedia.org/wiki/Molybdopterin
Enzyme inhibitorEnzyme inhibitor
The residues modified are those with side chains containing nucleophiles such as hydroxyl or sulfhydryl groups; these include ... A common treatment for erectile dysfunction is sildenafil (Viagra). This compound is a potent inhibitor of cGMP specific ... In many cases, allosteric, substrate competitive compounds result in conformational changes to the enzyme that change the ... Cohen JA, Oosterbaan RA, Berends F (1967). "[81] Organophosphorus compounds". Enzyme Structure. Methods in Enzymology. Vol. 11 ...
https://en.wikipedia.org/wiki/Enzyme_inhibitor
Hypochlorous acidHypochlorous acid
... some sulfhydryl function can be restored. One sulfhydryl-containing amino acid can scavenge up to four molecules of HClO. ... The resulting compound is a chlorohydrin. The polar chlorine disrupts lipid bilayers and could increase permeability. When ... could completely inactivate proteins containing sulfhydryl groups. This is because HClO oxidises sulfhydryl groups, leading to ... Its compounds will be called hypochlorites.) Unangst, P. C. "Hypochlorous Acid" in Encyclopedia of Reagents for Organic ...
https://en.wikipedia.org/wiki/Hypochlorous_acid
Acute inhalation injuryAcute inhalation injury
Phosgene directly reacts with amine, sulfhydryl, and alcohol groups, adversely affecting cell macromolecules and metabolism. ... is also used as an industrial reagent and building block in synthesis of pharmaceuticals and other organic compounds. Because ...
https://en.wikipedia.org/wiki/Acute_inhalation_injury
CyanaseCyanase
Denaturation, renaturation, and role of sulfhydryls and oligomeric structure in catalytic activity". The Journal of Biological ... supplying energetic Nitrogen compounds to the organism. The activity of cyanase is heavily dependent on the present of ...
https://en.wikipedia.org/wiki/Cyanase
Dough conditionerDough conditioner
Di Carlo, F.J.; Schultz, A.S.; McManus, D.K. (1951). "The assimilation of nucleic acid derivatives and related compounds by ... Dehydroascorbic acid and potassium bromate are oxidants, acting on sulfhydryl groups and disulfide bonds in wheat dough, in ...
https://en.wikipedia.org/wiki/Dough_conditioner
4-Amino-2-methyl-1-naphthol4-Amino-2-methyl-1-naphthol
Vitamin K function of the compound was first noted in 1940. Oral lethal dose for the HCl salt in rats is 0.7 g/kg. 4-Amino-2- ... Heisler CR, Yang, HY (1966). "Non-stoichiometric sulfhydryl loss with vitamin K5". Biochemical and Biophysical Research ... 1940). "Parenteral administration of a watersoluble compound with vitamin K activity: 4-amino-2-methyl-1-naphthol hydrochloride ... Chemical articles with multiple compound IDs, Chemicals using indexlabels, Chemical articles with multiple CAS registry numbers ...
https://en.wikipedia.org/wiki/4-Amino-2-methyl-1-naphthol
Ellmans reagentEllman's reagent
Thiols react with this compound, cleaving the disulfide bond to give 2-nitro-5-thiobenzoate (TNB−), which ionizes to the TNB2− ... Quantitation of sulfhydryls DTNB, Ellman's reagent (uses incorrect absorbance coefficient) (Articles without KEGG source, ECHA ... Riener CK, Kada G, Gruber HJ (2002). "Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'- ... Riener, Christian K.; Kada, Gerald; Gruber, Hermann J. (2002-07-01). "Quick measurement of protein sulfhydryls with Ellman's ...
https://en.wikipedia.org/wiki/Ellman's_reagent
HypothiocyaniteHypothiocyanite
... is the anion [OSCN]− and the conjugate base of hypothiocyanous acid (HOSCN). It is an organic compound part of ... Thomas EL, Aune TM (May 1978). "Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl ... Initially, this particular lactoperoxidase-catalyzed compound was originally discovered while viewing the specific environment ... against bacteria is reported to be caused by sulfhydryl (SH) oxidation. The oxidation of -SH groups in the bacterial ...
https://en.wikipedia.org/wiki/Hypothiocyanite
CaptoprilCaptopril
... was developed from this peptide after it was found via QSAR-based modification that the terminal sulfhydryl moiety of ... Proline derivatives and related compounds, methods for their manufacturing and their use as a medicinal product]", published ... is consistent with the observation that animal screening models indicate putative antidepressant activity for this compound, ...
https://en.wikipedia.org/wiki/Captopril
List of MeSH codes (D27)List of MeSH codes (D27)
... chromogenic compounds MeSH D27.720.233.348 - fluorescent dyes MeSH D27.720.233.674 - food coloring agents MeSH D27.720.269.189 ... sulfhydryl reagents MeSH D27.720.470.410.750 - thiobarbituric acid reactive substances MeSH D27.720.470.420 - ion exchange ... chromogenic compounds MeSH D27.720.470.410.210 - cross-linking reagents MeSH D27.720.470.410.360 - intercalating agents MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)
Potassium arsenitePotassium arsenite
Additionally, arsenite containing compounds have also been labeled carcinogens. The carcinogenicity of potassium arsenite ... The toxicity of potassium arsenite arises from arsenic's high affinity for sulfhydryl groups. The formation of these arsenite- ... Potassium arsenite (KAsO2) is an inorganic compound that exists in two forms, potassium meta-arsenite (KAsO2) and potassium ... Thus, exposure to potassium arsenite and other arsenite containing compounds results in the production of damaging oxygen free ...
https://en.wikipedia.org/wiki/Potassium_arsenite
PhthalaldehydePhthalaldehyde
The compound was first described in 1887 when it was prepared from α,α,α',α'-tetrachloro-ortho-xylene. A more modern synthesis ... OPA is used in a very sensitive fluorescent reagent for assaying amines or sulfhydryls in solution, notably contained in ... This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino ... Phthalaldehyde (sometimes also o-phthalaldehyde or ortho-phthalaldehyde, OPA) is the chemical compound with the formula C6H4( ...
https://en.wikipedia.org/wiki/Phthalaldehyde
Nitrogen dioxide poisoningNitrogen dioxide poisoning
... to the sulfhydryl form glutathione (GSH), which is a critical molecule in resisting oxidative stress and maintaining the ... on non-polar compounds that contain an electrophilic carbon and nitrogen. These inhibition mechanisms generates free radicals ... Inorganic nitrogen compounds, Nitrogen oxides, Hazardous air pollutants, Smog, Free radicals, Food additives, Toxic effects of ...
https://en.wikipedia.org/wiki/Nitrogen_dioxide_poisoning
AcetylcysteineAcetylcysteine
The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. N-acetyl-L-cysteine is soluble in ... "L-Cysteine, N-acetyl- - Compound Summary". PubChem. National Center for Biotechnology Information. 25 March 2005. ... US3091569A, Leonard, Sheffner Aaron, "Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus", ... issued 28 May 1963 US patent 3091569, Aaron Leonard Sheffner, "Mucolytic-N-acylated sulfhydryl compositions and process for ...
https://en.wikipedia.org/wiki/Acetylcysteine
CyclophosphamideCyclophosphamide
A small proportion of aldophosphamide freely diffuses into cells, where it is decomposed into two compounds, phosphoramide ... a sulfhydryl donor which binds and detoxifies acrolein. Intermittent dosing of cyclophosphamide decreases cumulative drug dose ... Chloroethyl compounds, World Health Organization essential medicines, Wikipedia medicine articles ready to translate). ... Brock and his team synthesised and screened more than 1,000 candidate oxazaphosphorine compounds. They converted the base ...
https://en.wikipedia.org/wiki/Cyclophosphamide
UreaseUrease
The breakdown of this intermediate is then helped by a sulfhydryl group of a cysteine located near the active site. A hydrogen ... and related compounds". Canadian Journal of Biochemistry. 58 (12): 1335-1344. doi:10.1139/o80-181. PMID 6788353. Zimmer M (Apr ...
https://en.wikipedia.org/wiki/Urease
ChemotherapyChemotherapy
Derivatives of these compounds include epirubicin and idarubicin. Other clinically used drugs in the anthracycline group are ... They impair cell function by forming covalent bonds with the amino, carboxyl, sulfhydryl, and phosphate groups in biologically ... The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. ... Liu YQ, Yang L, Tian X (2007). "Podophyllotoxin: current perspectives". Current Bioactive Compounds. 3 (1): 37-66. doi:10.1016/ ...
https://en.wikipedia.org/wiki/Chemotherapy
Perchloromethyl mercaptanPerchloromethyl mercaptan
The compound slowly hydrolyzes: CSCl4 + 2 H2O → CO2 + 4 HCl + 1⁄8 S8 The compound is corrosive to most metals. It reacts with ... sulfhydryl, amino and carboxyl groups. This results in an inactivation of key enzymes. A second general pathway reaction is the ... Organosulfur compounds, Trichloromethyl compounds, Pulmonary agents, Foul-smelling chemicals). ... Perchloromethyl mercaptan is the organosulfur compound with the formula CCl3SCl. It is mainly used as an intermediate for the ...
https://en.wikipedia.org/wiki/Perchloromethyl_mercaptan
Urine test stripUrine test strip
However, as these compounds are derived from the acetoacetic acid their existence can be assumed and a separate test is not ... Those medicines that contain sulfhydryl groups, such as mercaptoethane sulphonate Na (Mesna) and captopril and L-DOPA can give ... The three ketone compounds appear in different proportions in the urine, although these proportions are relatively constant in ... Bilirubin is a highly pigmented compound that is a by-product of haemoglobin degradation. The haemoglobin that is released ...
https://en.wikipedia.org/wiki/Urine_test_strip
Cyanogen bromideCyanogen bromide
... and synthesize other compounds. The compound is classified as a pseudohalogen. The carbon atom in cyanogen bromide is bonded to ... However, if the adjacent amino acid to methionine has a hydroxyl or sulfhydryl group, this group can react with the imine to ... Bromine compounds, Cyano compounds, Nonmetal halides, Blood agents, Lachrymatory agents, Pseudohalogens). ... Cyanogen bromide is the inorganic compound with the formula (CN)Br or BrCN. It is a colorless solid that is widely used to ...
https://en.wikipedia.org/wiki/Cyanogen_bromide
巯基乙酸正丁酯-Sulfhydryl compounds-Qingdao Open Sesame Mining Co., Ltd.巯基乙酸正丁酯-Sulfhydryl compounds-Qingdao Open Sesame Mining Co., Ltd.
项目 指标 外观 无色透明液体 纯度（%） 98.0 密度(20，g/cm 3 ) 1.020~1.040 色度（Pt－Co） 10
http://sesamemining.com/products/yijichanpinfenlei/qiujihuahewulei/147.html
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzymeAerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme
Sulfhydryl Compounds / chemistry * Sulfhydryl Compounds / metabolism* Substances * Acyl Coenzyme A * Bacterial Proteins ...
https://pubmed.ncbi.nlm.nih.gov/15916608/
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Sulfhydryl Compounds Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Sulfhydryl+Compounds&parentid=24798&catid=24764
Morphogenesis - 2nd EditionMorphogenesis - 2nd Edition
d. Sulphydryl Compounds. e. Tyrosine. f. Arginine. g. Tryptophanc. h. Ascorbic Acid (Vitamin C). i. Alkaline Phosphatase. j . ...
https://www.elsevier.com/books/morphogenesis/raven/978-1-4832-1338-5
NIOSHTIC-2 Search Results - Full View
Mercury compounds reacting with sulfhydryl groups inhibit a variety of enzymes. Chronic occupational exposure to mercury ... Occupational-exposure; Environmental-exposure; Lead-compounds; Cadmium-compounds; Mercury-compounds; Arsenic-compounds; Acute- ... Organic compounds of mercury are used in agriculture and have environmental and occupational impacts. ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=skin&t3=1&f1=%2A&s5=percutaneous&Startyear=&t1=1&s2=dermal&t4=1&terms=7&Adv=1&ct=&B1=Search&f2=%2A&t2=1&Limit=500&Sort=DP+DESC&s3=dermatitis&f3=%2A&s4=cutaneous&EndYear=&f4=%2A&f5=%2A&whichdate=DP&D1=10&PageNo=353&RecNo=3521&View=f&
Clinical reliability of non-organoleptic oral malodour measurementsClinical reliability of non-organoleptic oral malodour measurements
Sulfhydryl Compounds / analysis * Sulfur Compounds / analysis* * Tongue / pathology * Volatile Organic Compounds / analysis ... Aim: Measurement of volatile sulphur compounds (VSC) by portable sulphur monitors (Halimeter, OralChroma) is a common practice ...
https://pubmed.ncbi.nlm.nih.gov/19843192/?dopt=Abstract
TPMT gene: MedlinePlus GeneticsTPMT gene: MedlinePlus Genetics
... specific chemical reaction called S-methylation of a group of molecules known as aromatic and heterocyclic sulphydryl compounds ... Once inside the body, thiopurine drugs are converted to toxic compounds that kill immune system cells in the bone marrow. The ... Without enough of this enzyme, the body cannot "turn off" thiopurine drugs by metabolizing them into inactive compounds. The ... TPMT enzyme "turns off" thiopurine drugs by metabolizing them to inactive, nontoxic compounds. ...
https://medlineplus.gov/genetics/gene/tpmt/
Etymologia: Granulicatella - Volume 24, Number 9-September 2018 - Emerging Infectious Diseases journal - CDC
Spontaneous development of L forms of streptococci requiring secretions of other bacteria or sulphydryl compounds for normal ... or in media enriched with sulfhydryl compounds, such as cysteine. These nutritionally variant streptococci were eventually ...
https://wwwnc.cdc.gov/eid/article/24/9/et-2409_article
Molecular Biology (BMBB) - Research output - Experts@MinnesotaMolecular Biology (BMBB) - Research output - [email protected]
Mesnex (mesna) dosing, indications, interactions, adverse effects, and moreMesnex (mesna) dosing, indications, interactions, adverse effects, and more
Oxidized to dimesna in the blood, and is in turn reduced back to mesna in the kidney; synthetic sulfhydryl (thiol) compound ... Hypersensitivity to mesna or other thiol compounds. Cautions. Does NOT prevent nephrotoxicity, myelosuppression, or ...
http://reference.medscape.com/drug/mesnex-mesna-342126
Thiols as mechanistic probes for catalysis by the free radical enzyme galactose oxidase<...
Sulfhydryl Compounds Medicine & Life Sciences 65% * Galactose Chemical Compounds 62% * Free Radicals Medicine & Life Sciences ...
https://asu.pure.elsevier.com/en/publications/thiols-as-mechanistic-probes-for-catalysis-by-the-free-radical-en
Biblio | College of Agricultural Sciences
Filters: Keyword is Sulfhydryl Compounds and Author is Angela Hunt [Clear All Filters] ...
https://cropandsoil.oregonstate.edu/biblio?f%5Bkeyword%5D=4216&f%5Bauthor%5D=40596&s=title&o=asc
Renal Artery Stenosis Medication: Angiotensin-converting enzyme inhibitors, Angiotensin II receptor antagonists, HMG-CoA...Renal Artery Stenosis Medication: Angiotensin-converting enzyme inhibitors, Angiotensin II receptor antagonists, HMG-CoA...
Parent compound of this class of medications. Sulfhydryl group associated with proteinuria and neutropenia when used at high ... Initial compound in class to gain approval. Useful for treatment of hypertension and heart failure in patients who are ... One of many compounds with comparable efficacy and adverse effect profiles. Inhibits HMG-CoA reductase, which, in turn, ... Many alternative compounds exist with few significant clinical differences. Nonpeptide angiotensin II receptor antagonist that ...
https://www.medscape.com/answers/245023-80835/which-medications-in-the-drug-class-angiotensin-converting-enzyme-inhibitors-are-used-in-the-treatment-of-renal-artery-stenosis
SciELO - Brazil - Mercury distribution in different tissues and trophic levels of fish from a tropical reservoir, Brazil...SciELO - Brazil - Mercury distribution in different tissues and trophic levels of fish from a tropical reservoir, Brazil...
Water-soluble Hg compounds attach to sulfhydryl bonds present in the amino acids cysteine and methionine. However, those two ... Experimental study of trophic contamination of Salmo gairdneri by two mercury compounds (HCl2 and CH3HgCl)-analysis at the ... Therefore, mainly liposoluble complexes (and, consequently, lipo-soluble Hg compounds) may be attached to the gonads. ...
https://www.scielo.br/j/ni/a/CkKSfvRFmP6xjVFW7t9sw5q/?lang=en
The EPA National Library Catalog | EPA National Library Network | US EPAThe EPA National Library Catalog | EPA National Library Network | US EPA
A number of sulfhydryl-containing compounds reduce the toxic effects of antimony, suggesting that it may bind to cellular ... The most stable valence states of antimony are Sb(3+) and Sb(5+). Numerous inorganic and organic compounds of antimony are ... Most of the common antimony compounds are slightly to readily soluble in water. Antimony is thought to exert its toxic effects ... sulfhydryl groups. Antimony has been reported to increase the activity of heme oxygenase, to increase the action of thyroid ...
https://cfpub.epa.gov/ols/catalog/advanced_brief_record.cfm?&FIELD1=SUBJECT&INPUT1=Enzyme%20activation&TYPE1=EXACT&LOGIC1=AND&COLL=&SORT_TYPE=MTIC&item_count=4
JCM | Free Full-Text | The Role of Antioxidants on Wound Healing: A Review of the Current EvidenceJCM | Free Full-Text | The Role of Antioxidants on Wound Healing: A Review of the Current Evidence
4) Conclusions: this review offers a map of the research on some of the antioxidant compounds with potential for use as wound ... Curcumin, NAC, quercetin and chitosan are the antioxidant compounds that shown some initial evidence of efficacy, but more ... Seven compounds with antioxidant activity were identified (Curcumin, N-acetyl cysteine, Chitosan, Gallic Acid, Edaravone, ... Crocin, Safranal and Quercetin) and 46 studies reporting the effects on the healing process of these antioxidants compounds ...
https://www.mdpi.com/2077-0383/10/16/3558
Saadi ABDUL VAHAB - Professor - BiotechnologySaadi ABDUL VAHAB - Professor - Biotechnology
Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including ... Compound heterozygosity for HbD Punjab and polyadenylation signal mutation causes clinically asymptomatic mild hypochromia and ...
https://www.researchgate.net/profile/Saadi-Abdul-Vahab
Erowid.org: Erowid Reference 3884 : The effects of some psychopharmcological agents on heat stress-induced changes in the...Erowid.org: Erowid Reference 3884 : The effects of some psychopharmcological agents on heat stress-induced changes in the...
A number of enzymes in carbohydrate and lipid metabolism depend upon glutathione and other sulfhydryl compounds such as ... It also maintains several enzymes in their active sulfhydryl form. ...
https://erowid.org/references/refs_view.php?ID=3884&S=Dandiya_PC&SField=Author
Jorge Castro Ribeiro - Fingerprint - Universidade NOVA de LisboaJorge Castro Ribeiro - Fingerprint - Universidade NOVA de Lisboa
Sulfhydryl Compounds 62% * Membranes 34% * Sulfur 27% * 1-ethyl-3-methylimidazolium 24% ...
https://novaresearch.unl.pt/en/persons/jorge-castro-ribeiro/fingerprints/
Munita, R.<...Munita, R.<...
Sulfhydryl Compounds 89% * Proteome 86% * Hematopoietic Stem Cells 81% 1 Citation (SciVal) ...
https://portal.research.lu.se/en/persons/roberto-munita
Produção científica</span>Produção científica</span>
Phenolic compounds and free sulfhydryl groups in whole grain wheat flour modified by xylanase ... Production of compounds with emulsifying properties by using agroindustrial residues. Revista Ciências Exatas e Naturais ( ...
https://www.upf.br/ppgcta/producao-cientifica
Dr Budwig's Cancer - The Problem and the Solution (Book Extract)
Everybody knows the sulfur-containing protein compound of the sulfhydryl group can be detected in all breathing tissues. ... these were medications for cancer therapy with the sulfhydryl group (sulfur-containing protein compounds). Everywhere I saw ... or 12 carbon compounds respectively. The unsaturated vital fatty acids really start in the chain with 18 carbon compounds. ... The carbon compounds are heavy matter, even in the fatty acid. If two people reach out to each other with two arms, then they ...
https://healingcancernaturally.com/lothar-hirneise-johanna-budwig.html
Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease<...
Sulfhydryl Compounds Medicine & Life Sciences 30% * Liver Medicine & Life Sciences 29% * Transferases Medicine & Life Sciences ...
https://moh-it.pure.elsevier.com/en/publications/oxidative-stress-and-pro-apoptotic-conditions-in-a-rodent-model-o
Division of General Surgery - Research output - Research Profiles at Washington University School of MedicineDivision of General Surgery - Research output - Research Profiles at Washington University School of Medicine
Ellmans Reagent | Reducing Reagents | Cross-Linking & Modification | Protein ResearchEllman's Reagent | Reducing Reagents | Cross-Linking & Modification | Protein Research
... water-soluble compound for quantifying free sulfhydryl groups in solution. It reacts with a free sulfhydryl group to yield a ... Ellmans reagent is very useful as a free sulfhydryl assay reagent due to its high specificity for -SH groups at neutral pH, ...
https://www.gbiosciences.com/Protein-Research/Cross-Linking-Modification/Reducing-Reagents/Ellman-s-Reagent
Protein oxidation and antioxidants in myocardial infarction - Fingerprint - Manipal Academy of Higher Education, Manipal,...
Sulfhydryl Compounds 47% * Oxidants 45% * Copper 43% * Iron 36% * Reactive Oxygen Species 35% ...
https://manipal.pure.elsevier.com/en/publications/protein-oxidation-and-antioxidants-in-myocardial-infarction/fingerprints/
Drug Discovery Unit - Research Outputs - Discovery - the University of Dundee Research Portal
Chemical CompoundsThiolCysteineWater-solubleSulfurGlutathioneSulphur compoundsSubstancesOrganicIntracellularThiolsReactsAssayOxidation ReactionDTNBEnzymesBacteriaToxicCyclophosphamide412nmMoleculesGroupMedicationsHypersensitivityBoiling temperatureClinicalDrugsAdverseActivityFoundCommon
Chemical Compounds1
  • In the healthcare setting, "alcohol" refers to two water-soluble chemical compounds-ethyl alcohol and isopropyl alcohol-that have generally underrated germicidal characteristics 482 . (cdc.gov)
Thiol7
  • Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (drugbank.com)
  • Measure peptide cysteines or other free, reduced sulfhydryls (-SH groups) in solution using this thiol-reactive, colored compound (Amax 412nm). (fishersci.com)
  • The term thiol refers to compounds containing sulfur. (balkanmedicaljournal.org)
  • Thiol-containing compounds are found in all body cells and are indispensable for life. (balkanmedicaljournal.org)
  • The more highly reduced form a thiol-containing compound has, the more stronger antioxidative activity it exerts. (balkanmedicaljournal.org)
  • In this article, antioxidant and antioxidative effects of garlic and some thiol-containing compounds are reviewed. (balkanmedicaljournal.org)
  • Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side chain constitute an interesting avenue of research for the study of new taxoid compounds. (ewha.ac.kr)
Cysteine3
  • In 1961, Frenkel and Hirsch described strains of streptococci isolated from cases of bacterial endocarditis that grew only in the presence of other bacteria, around which they formed satellite colonies, or in media enriched with sulfhydryl compounds, such as cysteine. (cdc.gov)
  • Ellman's Reagent (5,5′-dithio-bis-[2-nitrobenzoic acid]) is used to estimate sulfhydryl groups in a sample by comparing to a standard curve of a sulfhydryl-containing compound such as cysteine. (meltingpointathens.com)
  • Many people consume inadequate amounts of sulfur-containing compounds, such as methionine and cysteine. (humannaturellc.com)
Water-soluble2
  • Ellman's reagent is a versatile, water-soluble compound for quantifying free sulfhydryl groups in solution. (gbiosciences.com)
  • In 1959, Ellman introduced 5,5′-dithio-bis-(2-nitrobenzoic acid), also known as DTNB, as a versatile water-soluble compound for quantitating free sulfhydryl groups in solution. (meltingpointathens.com)
Sulfur5
  • At this time, 1951, many applications had been submitted to me for approval, or to be more precise, these were medications for cancer therapy with the sulfhydryl group (sulfur-containing protein compounds). (healingcancernaturally.com)
  • Everybody knows the sulfur-containing protein compound of the sulfhydryl group can be detected in all breathing tissues. (healingcancernaturally.com)
  • The figures below show the boiling and melting point for organic sulfur compounds as sulfides, disulfides, thiols (mercaptans) and thiophenes , together with the molecular structures of the different compounds. (engineeringtoolbox.com)
  • Biotics Research's MSM provides a supplemental source of methylsulfonylmethane, an organic sulfur containing compound. (humannaturellc.com)
  • MSM (methylsulfonylmethane) is a natural compound found in plants and animals, MSM is a normal oxidation product of dimethyl sulfoxide (DMSO), and is a part of the natural global sulfur cycle. (humannaturellc.com)
Glutathione2
  • A number of enzymes in carbohydrate and lipid metabolism depend upon glutathione and other sulfhydryl compounds such as coenzyme A for their activity. (erowid.org)
  • Glutathione dihydrogenase acts on the reabsorbed portion and produces free sulfhydryl groups. (drugbank.com)
Sulphur compounds2
  • Measurement of volatile sulphur compounds (VSC) by portable sulphur monitors (Halimeter, OralChroma) is a common practice for diagnosis of oral malodour. (nih.gov)
  • rather it occurs in an interplay between the positive electrically-charged sulphur compounds in the protein, and some kind of fatty substance that we cannot detect, because no verifications for it are available. (healingcancernaturally.com)
Substances1
  • Antimetabolites are structural analogues of naturally occurring compounds and function as fraudulent substances for vital biochemical reactions. (medicinalplants.us)
Organic2
  • Organic compounds of mercury are used in agriculture and have environmental and occupational impacts. (cdc.gov)
  • Numerous inorganic and organic compounds of antimony are known. (epa.gov)
Intracellular1
  • Additionally, intracellular sulfhydryl groups are necessary for the catalytic function of numerous enzymes. (humannaturellc.com)
Thiols1
  • Protein thiols, GSH, other low-molecular-weight thiols, and the seleno-compound ebselen react, in a nonstoichiometric manner, with both peptide and protein peroxides. (ku.dk)
Reacts4
  • It reacts with a free sulfhydryl group to yield a mixed disulfide and 2-nitro-5-thiobenzoic acid (NTB), a measurable yellow colored product at 412nm. (gbiosciences.com)
  • A solution of this compound produces a measurable yellow-colored product when it reacts with sulfhydryls. (meltingpointathens.com)
  • DTNB reacts with a free sulfhydryl group to yield a mixed disulfide and 2-nitro-5-thiobenzoic acid (TNB). (meltingpointathens.com)
  • DTNB (Ellman's Reagent) (5,5-dithio-bis-(2-nitrobenzoic acid) Thermo Scientific Pierce Ellman's Reagent (DTNB) reacts with sulfhydryl groups to yield a colored product, providing a reliable method to measure reduced cysteines and other free sulfhydryls in solution. (meltingpointathens.com)
Assay2
  • Ellman's reagent is very useful as a free sulfhydryl assay reagent due to its high specificity for -SH groups at neutral pH, high molar extinction coefficient and short reaction time. (gbiosciences.com)
  • Ellman's assay is a useful tool that can be used to determine the sulfhydryl concentration of unknown solutions. (meltingpointathens.com)
Oxidation Reaction1
  • Dihydrolipoic acid has two sulfhydryl groups and it can undergo further oxidation reaction forming lipoic acid. (balkanmedicaljournal.org)
DTNB1
  • The target of DTNB in this reaction is the conjugate base (R-S-) of a free sulfhydryl group. (meltingpointathens.com)
Enzymes2
  • Mercury compounds reacting with sulfhydryl groups inhibit a variety of enzymes. (cdc.gov)
  • It also maintains several enzymes in their active sulfhydryl form. (erowid.org)
Bacteria2
  • Frenkel A , Hirsch W . Spontaneous development of L forms of streptococci requiring secretions of other bacteria or sulphydryl compounds for normal growth. (cdc.gov)
  • forms of streptococci requiring secretions of other bacteria or sulphydryl compounds for normal growth. (cdc.gov)
Toxic4
  • Once inside the body, thiopurine drugs are converted to toxic compounds that kill immune system cells in the bone marrow. (medlineplus.gov)
  • A number of sulfhydryl-containing compounds reduce the toxic effects of antimony, suggesting that it may bind to cellular sulfhydryl groups. (epa.gov)
  • These free sulfhydryl groups bind acrolein in the bladder, allowing effective excretion and prevention of toxic effects. (drugbank.com)
  • Those compounds were irradiated in the presence of two non-cancer cell lines and were found equally toxic only upon irradiation and not in the dark. (bvsalud.org)
Cyclophosphamide1
  • Alkylating agents, such as the platinum compounds and cyclophosphamide, prevent cell division primarily by cross-linking strands of DNA. (oncohemakey.com)
412nm1
  • Alternatively, sulfhydryl groups can be assayed using the extinction coefficient of TNB (14,150M-1 cm-1 at 412nm). (meltingpointathens.com)
Molecules1
  • This enzyme carries out a specific chemical reaction called S-methylation of a group of molecules known as aromatic and heterocyclic sulphydryl compounds. (medlineplus.gov)
Group3
  • Sulfhydryl group associated with proteinuria and neutropenia when used at high doses. (medscape.com)
  • Through official channels I had the right to ask the companies questions relative to how they wanted to substantiate how this substance (sulfhydryl group) could help with cancer. (healingcancernaturally.com)
  • However another partner must be present in the interplay with this sulfhydryl group, because the self-active oxygen consumption in the living system is executed in a zig zag curve. (healingcancernaturally.com)
Medications2
  • Parent compound of this class of medications. (medscape.com)
  • In this situation I noticed the sulfhydryl groups in my appraisal of the medications for cancer therapy. (healingcancernaturally.com)
Hypersensitivity1
  • The taxanes and platinum compounds are the most likely to cause hypersensitivity. (oncohemakey.com)
Boiling temperature1
  • It is not known whether these compounds are stable at the 1 atm boiling temperature or not. (engineeringtoolbox.com)
Clinical2
  • Many alternative compounds exist with few significant clinical differences. (medscape.com)
  • In the same decade, bleomycin, etoposide, and doxorubicin came into clinical use, and derivative compounds such as carboplatin, vinorelbine, and idarubicin were developed for their ability to achieve similar antitumor effects but with less hematologic toxicity. (oncohemakey.com)
Drugs2
  • The TPMT enzyme "turns off" thiopurine drugs by metabolizing them to inactive, nontoxic compounds. (medlineplus.gov)
  • Without enough of this enzyme, the body cannot "turn off" thiopurine drugs by metabolizing them into inactive compounds. (medlineplus.gov)
Adverse1
  • One of many compounds with comparable efficacy and adverse effect profiles. (medscape.com)
Activity1
  • Mechanism of action of gliotoxin: elimination of activity by sulfhydryl compounds. (wikidata.org)
Found1
  • Moving to in vitro experiments, irradiation was found to slightly enhance the death of the cells in the majority of the compounds. (bvsalud.org)
Common1
  • Most of the common antimony compounds are slightly to readily soluble in water. (epa.gov)
TPMT gene: MedlinePlus Genetics
TPMT gene: MedlinePlus Genetics (medlineplus.gov)
Thiols as mechanistic probes for catalysis by the free radical enzyme galactose oxidase<...
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JCM | Free Full-Text | The Role of Antioxidants on Wound Healing: A Review of the Current Evidence
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Diabetes, Obesity, Metabolism and Nutrition | 0070 | ECE2020 | 22nd European Congress of Endocrinology | Endocrine Abstracts
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Jorge Castro Ribeiro - Fingerprint - Universidade NOVA de Lisboa
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Munita, R.<...
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PDF) Glutathione Metabolism and Its Implications for Health
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Agronomy | Free Full-Text | In-Vitro Inhibition of Pythium ultimum, Fusarium graminearum, and Rhizoctonia solani by a...
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Protein oxidation and antioxidants in myocardial infarction - Fingerprint - Manipal Academy of Higher Education, Manipal,...
Protein oxidation and antioxidants in myocardial infarction - Fingerprint - Manipal Academy of Higher Education, Manipal,... (manipal.pure.elsevier.com)
Drug Discovery Unit - Research Outputs - Discovery - the University of Dundee Research Portal
Drug Discovery Unit - Research Outputs - Discovery - the University of Dundee Research Portal (discovery.dundee.ac.uk)
How do you dissolve in DTNB? - Meltingpointathens.com
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Reusable nano-sized chiral bisoxazoline catalysts<...
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Faculty of Pharmacy - Research output - Keio University
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Daniel Nieva - Fingerprint - Research Profiles at Washington University School of Medicine
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Peter Zuber - Publications - Oregon Health & Science University
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Faculty Of Computing, Eng. & Built Env. - Research output - Ulster University
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Coenzyme M: Uses, Interactions, Mechanism of Action | DrugBank Online
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BSN Weekly Information Session | American University of Health Sciences
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Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer<...
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Connection | Profiles RNS
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High Quality Cysteamine hydrochloride_Zhishang Chemcial
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Tzyh-Chang Hwang - 研究成果 - 國立陽明交通大學研發優勢分析平台
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A Large Reservoir of Sulfate and Sulfonate Resides within Plasma Cells from Ascidia ceratodes, Revealed by X-ray Absorption...
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College of Engineering - Research output - Korea University
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Antioxidative Effects of Garlic and Some Thiol-Containing Compounds - Balkan Medical Journal
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COVID-19: A Brief Overview
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