Compounds containing the -SH radical.
Sulfhydryl acylated derivative of GLYCINE.
A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
The rate dynamics in chemical or physical systems.
A sulfhydryl reagent that is widely used in experimental biochemical studies.
A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.
Chloride and mercury-containing derivatives of benzoic acid.
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
Mercury-containing benzoic acid derivatives.
An organic mercurial used as a sulfhydryl reagent.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
Software application for retrieving, presenting and traversing information resources on the World Wide Web.
Specific languages used to prepare computer programs.
Organized activities related to the storage, location, search, and retrieval of information.
3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
A plant genus of the family BORAGINACEAE. Members contain TRITERPENES and naphthoxirene.
A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Substances that cause the adherence of two surfaces. They include glues (properly collagen-derived adhesives), mucilages, sticky pastes, gums, resins, or latex.
A country spanning from central Asia to the Pacific Ocean.
Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
The part of a denture that overlies the soft tissue and supports the supplied teeth and is supported in turn by abutment teeth or the residual alveolar ridge. It is usually made of resins or metal or their combination.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
A characteristic symptom complex.
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The veins and arteries of the HEART.
Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.
The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.
Multicellular marine macroalgae including some members of red (RHODOPHYTA), green (CHLOROPHYTA), and brown (PHAEOPHYTA) algae. They are widely distributed in the ocean, occurring from the tide level to considerable depths, free-floating (planktonic) or anchored to the substratum (benthic). They lack a specialized vascular system but take up fluids, nutrients, and gases directly from the water. They contain CHLOROPHYLL and are photosynthetic, but some also contain other light-absorbing pigments. Many are of economic importance as FOOD, fertilizer, AGAR, potash, or source of IODINE.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Silicone polymers which consist of silicon atoms substituted with methyl groups and linked by oxygen atoms. They comprise a series of biocompatible materials used as liquids, gels or solids; as film for artificial membranes, gels for implants, and liquids for drug vehicles; and as antifoaming agents.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.

Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (1/4324)

The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties.  (+info)

Sulfhydryl compounds in melanocytes of yellow (Ay/a), nonagouti (a/a), and agouti (A/A) mice. (2/4324)

CLEFFMANN (1953, 1963a,b) has reported that yellow but not black melanocytes of agouti (A/A) rabbits contained reducing sulfhydryl compounds. We have attempted to repeat CLEFFMANN's observations in mouse melanocytes of the lethal yellow (Ay/a), nonagouti (a/a) and agouti (A/A) genotypes. Our results contradict those of CLEFFMANN and reveal that yellow and black melanocytes, regardless of genotype, possess equivalent amounts of histochemically detectable sulfhydryl compounds. These results do not support the hypothesis that agouti-locus genes act by controlling the sulfhydryl metabolism of pigment cells.  (+info)

Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II. (3/4324)

Myeloperoxidase (MPO) is the most abundant protein in neutrophils and plays a central role in microbial killing and inflammatory tissue damage. Because most of the non-steroidal anti-inflammatory drugs and other drugs contain a thiol group, it is necessary to understand how these substrates are oxidized by MPO. We have performed transient kinetic measurements to study the oxidation of 14 aliphatic and aromatic mono- and dithiols by the MPO intermediates, Compound I (k3) and Compound II (k4), using sequential mixing stopped-flow techniques. The one-electron reduction of Compound I by aromatic thiols (e.g. methimidazole, 2-mercaptopurine and 6-mercaptopurine) varied by less than a factor of seven (between 1.39 +/- 0.12 x 10(5) M(-1) s(-1) and 9.16 +/- 1.63 x 10(5) M(-1) s(-1)), whereas reduction by aliphatic thiols was demonstrated to depend on their overall net charge and hydrophobic character and not on the percentage of thiol deprotonation or redox potential. Cysteamine, cysteine methyl ester, cysteine ethyl ester and alpha-lipoic acid showed k3 values comparable to aromatic thiols, whereas a free carboxy group (e.g. cysteine, N-acetylcysteine, glutathione) diminished k3 dramatically. The one-electron reduction of Compound II was far more constrained by the nature of the substrate. Reduction by methimidazole, 2-mercaptopurine and 6-mercaptopurine showed second-order rate constants (k4) of 1.33 +/- 0.08 x 10(5) M(-1) s(-1), 5.25 +/- 0.07 x 10(5) M(-1) s(-1) and 3.03 +/- 0.07 x 10(3) M(-1) s(-1). Even at high concentrations cysteine, penicillamine and glutathione could not reduce Compound II, whereas cysteamine (4.27 +/- 0.05 x 10(3) M(-1) s(-1)), cysteine methyl ester (8.14 +/- 0.08 x 10(3) M(-1) s(-1)), cysteine ethyl ester (3.76 +/- 0.17 x 10(3) M(-1) s(-1)) and alpha-lipoic acid (4.78 +/- 0.07 x 10(4) M(-1) s(-1)) were demonstrated to reduce Compound II and thus could be expected to be oxidized by MPO without co-substrates.  (+info)

Thiol-dependent degradation of protoporphyrin IX by plant peroxidases. (4/4324)

Protoporphyrin IX (PP) is the last porphyrin intermediate in common between heme and chlorophyll biosynthesis. This pigment normally does not accumulate in plants because its highly photodynamic nature makes it toxic. While the steps leading to heme and chlorophylls are well characterized, relatively little is known of the metabolic fate of excess PP in plants. We have discovered that plant peroxidases can rapidly degrade this pigment in the presence of thiol-containing substrates such as glutathione and cysteine. This thiol-dependent degradation of PP by horseradish peroxidase consumes oxygen and is inhibited by ascorbic acid.  (+info)

Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes. (5/4324)

Selenium has been increasingly recognized as an essential element in biology and medicine. Its biochemistry resembles that of sulfur, yet differs from it by virtue of both redox potentials and stabilities of its oxidation states. Selenium can substitute for the more ubiquitous sulfur of cysteine and as such plays an important role in more than a dozen selenoproteins. We have chosen to examine zinc-sulfur centers as possible targets of selenium redox biochemistry. Selenium compounds release zinc from zinc/thiolate-coordination environments, thereby affecting the cellular thiol redox state and the distribution of zinc and likely of other metal ions. Aromatic selenium compounds are excellent spectroscopic probes of the otherwise relatively unstable functional selenium groups. Zinc-coordinated thiolates, e.g., metallothionein (MT), and uncoordinated thiolates, e.g., glutathione, react with benzeneseleninic acid (oxidation state +2), benzeneselenenyl chloride (oxidation state 0) and selenocystamine (oxidation state -1). Benzeneseleninic acid and benzeneselenenyl chloride react very rapidly with MT and titrate substoichiometrically and with a 1:1 stoichiometry, respectively. Selenium compounds also catalyze the release of zinc from MT in peroxidation and thiol/disulfide-interchange reactions. The selenoenzyme glutathione peroxidase catalytically oxidizes MT and releases zinc in the presence of t-butyl hydroperoxide, suggesting that this type of redox chemistry may be employed in biology for the control of metal metabolism. Moreover, selenium compounds are likely targets for zinc/thiolate coordination centers in vivo, because the reactions are only partially suppressed by excess glutathione. This specificity and the potential to undergo catalytic reactions at low concentrations suggests that zinc release is a significant aspect of the therapeutic antioxidant actions of selenium compounds in antiinflammatory and anticarcinogenic agents.  (+info)

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (6/4324)

The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan.  (+info)

Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. (7/4324)

4-Hydroxy-2-nonenal (HNE) is a major lipid peroxidation product formed during oxidative stress. Because of its reactivity with nucleophilic compounds, particularly metabolites and proteins containing thiol groups, HNE is cytotoxic. The aim of this study was to assess the extent and time course for the formation of HNE-modified proteins during ischemia and ischemia plus reperfusion in isolated rat hearts. With an antibody to HNE-Cys/His/Lys and densitometry of Western blots, we quantified the amount of HNE-protein adduct in the heart. By taking biopsies from single hearts (n = 5) at various times (0, 5, 10, 15, 20, 35, and 40 min) after onset of zero-flow global ischemia, we showed a progressive, time-dependent increase (which peaked after 30 min) in HNE-mediated modification of a discrete number of proteins. In studies with individual hearts (n = 4/group), control aerobic perfusion (70 min) resulted in a very low level (296 arbitrary units) of HNE-protein adduct formation; by contrast, after 30-min ischemia HNE-adduct content increased by >50-fold (15,356 units, P < 0.05). In other studies (n = 4/group), administration of N-(2-mercaptopropionyl)glycine (MPG, 1 mM) to the heart for 5 min immediately before 30-min ischemia reduced HNE-protein adduct formation during ischemia by approximately 75%. In studies (n = 4/group) that included reperfusion of hearts after 5, 10, 15, or 30 min of ischemia, there was no further increase in the extent of HNE-protein adduct formation over that seen with ischemia alone. Similarly, in experiments with MPG, reperfusion did not significantly influence the tissue content of HNE-protein adduct. Western immunoblot results were confirmed in studies using in situ immunofluorescent localization of HNE-protein in cryosections. In conclusion, ischemia causes a major increase in HNE-protein adduct that would be expected to reflect a toxic sequence of events that might act to compromise tissue survival during ischemia and recovery on reperfusion.  (+info)

Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress. (8/4324)

The irreversible oxidation of cysteine residues can be prevented by protein S-thiolation, in which protein -SH groups form mixed disulfides with low-molecular-weight thiols such as glutathione. We report here the identification of glyceraldehyde-3-phosphate dehydrogenase as the major target of protein S-thiolation following treatment with hydrogen peroxide in the yeast Saccharomyces cerevisiae. Our studies reveal that this process is tightly regulated, since, surprisingly, despite a high degree of sequence homology (98% similarity and 96% identity), the Tdh3 but not the Tdh2 isoenzyme was S-thiolated. The glyceraldehyde-3-phosphate dehydrogenase enzyme activity of both the Tdh2 and Tdh3 isoenzymes was decreased following exposure to H2O2, but only Tdh3 activity was restored within a 2-h recovery period. This indicates that the inhibition of the S-thiolated Tdh3 polypeptide was readily reversible. Moreover, mutants lacking TDH3 were sensitive to a challenge with a lethal dose of H2O2, indicating that the S-thiolated Tdh3 polypeptide is required for survival during conditions of oxidative stress. In contrast, a requirement for the nonthiolated Tdh2 polypeptide was found during exposure to continuous low levels of oxidants, conditions where the Tdh3 polypeptide would be S-thiolated and hence inactivated. We propose a model in which both enzymes are required during conditions of oxidative stress but play complementary roles depending on their ability to undergo S-thiolation.  (+info)

A system and method are provided for representing content made accessible by a group of users. In general, a group content representation that is descriptive of content made accessible by the group of users is presented to an interested user. In one embodiment, the users are represented by avatars in a virtual environment, and the group content representation is presented in a view of the virtual environment provided to the interested user. The group content representation may be presented at a fixed or dynamic location within the virtual environment. For example, the group content representation may be presented at a location relative to the avatars representing the group of users in the virtual environment. Based on the group content representation, the interested user is enabled to quickly and easily determine whether content of interest is accessible from the group of users.
In this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p < 0.001), and disulfide/total thiol (p < 0.001) were determined higher, while native thiol (p = 0.004) and total thiol (p < 0.001) levels were much lower. In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, ...
Thiols are the organic compounds that contain a sulphydryl group. Among all the antioxidants that are available in the body, thiols constitute the major portion of the total body antioxidants and they play a significant role in defense against reactive oxygen species. Total thiols composed of both intracellular and extracellular thiols either in the free form as oxidized or reduced glutathione, or thiols bound to proteins. Among the thiols that are bound to proteins, albumin makes the major portion of the protein bound thiols, which binds to sufhydryl group at its cysteine-34 portion. Apart from their role in defense against free radicals, thiols share significant role in detoxification, signal transduction, apoptosis and various other functions at molecular level. The thiol status in the body can be assessed easily by determining the serum levels of thiols. Decreased levels of thiols has been noted in various medical disorders including chronic renal failure and other disorders related to ...
Selective purification of the thiol peptides of myosin: 1. A method for selective purification of thiol peptides is described. Thiol groups in a protein are tre
Free radicals contribute to Type 1 diabetes (T1D) autoimmune responses. We recently demonstrated that superoxide-deficient CD4 T cells exhibited increased effector responses and diabetogenicity, but the redox-dependent mechanism(s) mediating T cell activation were unclear. We hypothesized that during T1D progression, CD4 T cells with a reduced cell surface state would exhibit a concomitant increase in pro-inflammatory cytokine and chemokine responses. To test this, alexa fluor 647-conjugated maleimide (ALM)-labeling of cell surface reduced thiols on diabetogenic mouse and human CD4 T cells was performed. We observed an increase in ALM percentage and gMFI from peripheral Non-obese diabetic (NOD) mouse CD4 T cells during progression to overt diabetes. Cognate autoantigen stimulation elicited a 2- and 20-fold increase in CD4 ALM T cell percentage and gMFI, respectively. In addition to serving as a T cell activation marker, ALM gMFI of reduced CD4 T cell surface thiols was enhanced (1.2-fold) with ...
Acute exposure of a nonsmoking subject to passive smoking resulted in deterioration of serum antioxidant defense, accelerated lipid peroxidation, and accumulation of LDL cholesterol in cultured human macrophages. These events were observed even after a very short period (30 minutes) of passive smoking. Indeed, it has previously been suggested that the cardiovascular system is extremely sensitive to the chemicals in environmental tobacco smoke.1 Furthermore, the oxidative stress induced by SHS may have a more prominent effect on a nonsmoking subject than on an active smoker whose cardiovascular system has adapted to CS.1 Oxidative stress induced by acute passive smoking significantly decreased plasma ascorbic acid and caused a minor, nonsignificant decrease in protein sulfhydryl groups, reflecting increased use of these antioxidants. This is in line with previous studies demonstrating that long-term exposure to SHS decreases plasma ascorbic acid in both active and passive smokers.7 12 ...
Bacteria are exposed to oxidative stress as an unavoidable consequence of their aerobic lifestyle. Reactive oxygen species (ROS) are generated in the stepwise one-electron reduction of molecular oxygen during the respiration. Pathogens encounter ROS during the oxidative burst of macrophages as part of the host immune defense. Besides ROS, bacteria also have to cope with reactive chlorine, electrophilic and nitrogen species (RCS, RES, RNS). To cope with these reactive species, bacteria have evolved different defense and repair mechanisms. To maintain the reduced state of the cytoplasm, they utilize low molecular weight (LMW) thiols. LMW thiols are small thiol-containing compounds that can undergo post-translational thiolmodifications with protein thiols, termed as S-thiolations. S-thiolations function as major redox regulatory and thiol-protection mechanism under oxidative stress conditions. In eukaryotes and Gram-negative bacteria, the tripeptide glutathione (GSH) functions as major LMW thiol, which is
The total thiols in a medium containing authentic biological sample (articular cartilage) has been determined electrochemically. The detection strategy utilises the electrochemical adaptation of the Ellmans reaction process via the electrochemically initiated reaction of thiols with diethyl-p-phenylenediamine. The strategy has been examined over a biologically significant pH range and the behaviour observed rationalised. The detection of thiols within the biological sample is shown to proceed with micromolar levels of thiol determined within the sample.
The tissue thiol levels of HGGs were found to be higher than the control group (p = 0.001). Although the median thiol levels of Grade 4 gliomas were higher than those of Grade 3, no statistically significant difference was noted (p = 0.076). When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001). The thiol levels of Grade 4 IDH1- gliomas were statistically significantly higher than of Grade 3 gliomas (p = 0.023), but no statistically significant difference between the thiol levels of Grade 3 and Grade 4 IDH1+ tumors was noted (p = 0.459 ...
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Background and Objective: Blood contains low concentration of thiols and some (thiols) are found in the albumin compartment. So far, little or no information exists on the relationship between serum total thiols and albumin in sub-chronic lead intoxication. To examine the relationship between serum total thiols and albumin in sub-chronic lead intoxicated rats supplemented with folic acid and/or vitamin C. Materials and Methods: This study was performed using 40 male albino rats weighing 160-190 g. The albino rats were divided into eight 8 of five each. Group 1-4 were sub-chronically intoxicated with lead fora period of 6 weeks, followed by supplementation with folic acid and/or vitamin C to group 2-7 fora period of 4 weeks. After the 10th week, the experimental rats were fasted overnight and sacrificed, after which their blood samples were collected. Results: Findings from this study revealed statistically significant (p,0.05) decrease in serum total thiols and albumin concentration in the ...
Glutathione (GSH)is the most abundant low molecular weight thiol and form of storage of SH-. Animal and human studies have demonstrated that adequate protein nutrition is crucial for the maintenance of GSH homeostasis [48]. Elevated levels of GSH inhibit prostaglandin production by a direct interaction with COX enzymes, of potential significance in the progression of inflammatory or degenerative states [36]. It is of particular interest, as discussed earlier that prostagandins synthesized from PUFA and most of the non-steroidal anti-inflammatory drugs share this same locus of involvement. It is also relevant that some recent studies have found that on occasions the pain reduction in OA associated with the administration of chondroitin sulfate, a source of sulfur, was found to be equivalent to that provided by NSAID. The reasons for such unpredictable results, we suspect could be associated with differences in levels of protein in the diet, the better responders consuming higher amounts of SAA. ...
Come join fellow Shibas and their servants/owners for playdates with other local Shibas. Many of our members have great Shiba stories, and many tips on how to deal with our very strong-minded dogs. We
Come join fellow Shibas and their servants/owners for playdates with other local Shibas. Many of our members have great Shiba stories, and many tips on how to deal with our very strong-minded dogs. We
In the present study, two commercial assays for the redox status are compared and evaluated, the SH groups in proteins (SHp) and the total thiol levels (TTL). Both assa..
Protocols for postsynthetic modification of 2‐amino‐containing oligoribonucleotides with either an alkyl‐phenyl disulfide or an alkyl thiol group are described
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
The global Tert-Dodecyl Mercaptan market was about 304 Million USD in 2015 and is expected to grow at a CAGR of 5.39% from 2017 to 2022. The global sales of
Maleimide Coated 96 Well Solid Plates offer a powerful instrument for binding biomolecules containing free sulfhydryl groups or reducibile disulfide bonds.
FAM226A (family with sequence similarity 226 member A (non-protein coding)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Q 8. A compound with molecular mass 180 is acylated with {tex} \mathrm { CH } _ { 3 } \mathrm { COCl } {/tex} to get a compound with molecular mass {tex} 390 . {/tex} The number of amino groups present per molecule of the former compound is: ...
For sulfhydryl-selective coupling of PEG to proteins and other thiol substrates and for selective scavenging of thiol containing peptides. ...
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105Rh[1,5,9,13-tetrathiacyclohexadecane-3,11-diol] is a promising drug precursor for targeted radiotherapy. Nevertheless, the axial position of chloride ions in the complex structure and their weak binding to rhodium centre, due to HSAB concept, make such a complex subject to modifying action of certain sulphuric ligands, like human plasma thiol antioxidants: glutathione and cysteine. Experiments were performed with both radioactive 105Rh and inactive rhodium. The complexation of rhodium with 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16S4diol) resulted in three distinct peaks seen on UV, radiometric and MS chromatograms. The substitution of chlorides was noted in over 80% of 105[Rh(16S4diol)Cl2]+ units after incubation with glutathione, and less than 10% of complex units after incubation with cysteine (24 h, 37 °C). Reaction of 105[Rh(16S4diol)Cl2]+ with 1,8-octandithiol and 1,9-nonandithiol resulted in disappearance of the complex peak and occurrence of two new peaks. Product of RhCl3 and ...
Fingerprint Dive into the research topics of Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide. Together they form a unique fingerprint. ...
The low molecular weight thiol (-SH) content of a human prostate carcinoma cell line (LNCap), important to the cellular resistance to drugs and irradiation, was investigated using three forms of thiol assay each utilizing different chemistries. The composition of the mixture was examined by derivatization of the thiols with a three-fold excess of the Ellman reagent to give mixed aromatic disulfides. The components were isolated by chromatography on C18 reverse phase silica gel followed by DE52 anion exchange separation, and then analyzed by capillary electrophoresis against prepared standards. The glutathione adduct (GSSE) and an unknown disulfide (RSSE) were the major components isolated on DE52 together with two minor ones. However, from the absorbance at 325 nm, it was found that the GSSE isolated (1.5 ± 0.2 femtomoles/cell) could only account for 28.5 ± 4.3% of the total ASF thiols. It appeared that the bulk of the thiol material had not formed a stable mixed disulfide with Ellmans reagent, and
This reaction is rapid and stoichiometric, with the addition of one mole of thiol releasing one mole of TNB. The TNB2− is quantified in a spectrophotometer by measuring the absorbance of visible light at 412 nm, using an extinction coefficient of 14,150 M−1 cm−1 for dilute buffer solutions,[3][4] and a coefficient of 13,700 M−1 cm−1 for high salt concentrations, such as 6 M guanidinium hydrochloride or 8 M urea.[4] Unfortunately the extinction coefficient for dilute solutions was underestimated in the original 1959 publication, as 13,600 M−1 cm−1, and as noted in a recent article, this mistake has persisted in the literature.[5] Commercial DTNB may not be completely pure, so may require recrystallization to obtain completely accurate and reproducible results.[4]. Ellmans reagent can be used for measuring low-molecular mass thiols such as glutathione in both pure solutions and biological samples, such as blood.[6] It can also measure the number of thiol groups on ...
1479501 Oxidizing mercaptans ASHLAND OIL Inc 1 Aug 1974 [7 Sept 1973] 34069/74 Heading C2C [Also in Divisions B1 and C5] Mercaptans and mercaptides are oxidized to the disulphides in aqueous alkaline solution in the presence of catalysts comprising a causticinert carrier impregnated with a tetrapyridinoporphyrazine or a tetrapyrazinoporphyrazine of the formula in which M is Cu, Ag, Mg, Zn, Hg, Th, Ti, Hf, Sn, Pb, V, Nb, Ta, Sb, Bi, Cr, Mo, Mn, Fe, Co, Ni, Pd or Pt, each R is H, alkyl, aralkyl or aryl or two adjacent R groups are constituents of a cyclic carbon structure, and X is =N- or = CR-. Examples describe the oxidation of nbutyl mercaptan in aqueous sodium hydroxide using air as oxidant and activated carbon impregnated with cobalt or vanadium tetrapyridinoporphyrazine as catalyst.
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Attempts to denature the surrounding protein scaffold, i. e. to isolate the photoadduct consisting of FMN and methyl mercaptan failed. The adduct is apparently very unstable. For this reason, it was impossible to identify the adduct via mass spectrometry. However the structure of the adduct could be confirmed by CD spectroscopy. Irradiation of free FMN in aqueous solution in the presence of methyl mercaptan did not yield the corresponding free adduct of FMN and methyl mercaptan, but the fully reduced hydroquinone form of FMN. Therefore, the protein scaffold carries out two different functions: It guides the photoreaction between FMN and methyl mercaptan to adduct formation and it stabilizes the photoadduct after its formation ...
TY - JOUR. T1 - Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS. T2 - Implications in excitotoxicity. AU - Diwakar, Latha. AU - Kenchappa, Rajappa S.. AU - Annepu, Jayasree. AU - Ravindranath, Vijayalakshmi. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/7. Y1 - 2007/7. N2 - Oxidative stress, excitotoxicity and mitochondrial dysfunction play synergistic roles in neurodegeneration. Maintenance of thiol homeostasis is important for normal mitochondrial function and dysregulation of protein thiol homeostasis by oxidative stress leads to mitochondrial dysfunction and neurodegeneration. We examined the critical roles played by the antioxidant, non-protein thiol, glutathione and related enzyme, glutaredoxin in maintaining mitochondrial function during excitotoxicity caused by β-N-oxalyl amino-l-alanine (l-BOAA), the causative factor of neurolathyrism, a motor neuron disease involving the pyramidal system. ...
Citation: N/A Interpretive Summary: Technical Abstract: In tomato, impaired reductive activation of the stromal bisphosphatases appears to be the dominating factor limiting carbon assimilation following chilling in the light. The illumination-dependent activation of at least seven different chloroplast enzymes involves the reversible thiol/disulfide exchange between thioredoxin and the photosynthetic enzyme. The thermodynamics of the thiol/disulfide exchange between thioredoxin and the regulatory sulfhydryl groups of the various light-regulated chloroplast enzymes explains the differential responses among the various thioredoxin-regulated enzymes to the effects of chilling in the light (Hutchison et al. 2000). In the case of dark chilling, an intriguing effect of low temperature on the circadian regulation of transcription indicates that the low-temperature induced inhibition of photosynthesis in tomato may result from the loss of coordination in the expression of critical enzymes controlling ...
Millington, Keith R, Maurdev, George and Jones, Michael J 2009, Mechanism of photoprotection of wool with formaldehyde and thiol derivatives, Coloration technology, vol. 125, no. 2, pp. 117-122, doi: 10.1111/j.1478-4408.2009.00183.x. ...
TY - JOUR. T1 - Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. AU - Dinkova-Kostova, Albena T.. AU - Holtzclaw, W. David. AU - Cole, Robert N.. AU - Itoh, Ken. AU - Wakabayashi, Nobunao. AU - Katoh, Yasutake. AU - Yamamoto, Masayuki. AU - Talalay, Paul. N1 - dc.publisher: National Academy of Sciences The first author designed and performed the experiments, and wrote the paper. The work was the first demonstration that inducers of cytoprotective responses are initially sensed in a chemical reaction with highly reactive sulfhydryl groups of the sensor protein Keap1. This finding has opened the field for many other investigators. dc.description.sponsorship: Lewis B. and Dorothy Cullman Foundation Barbara Lubin Goldsmith Foundation McMullan Family Fund National Cancer Institute Department of Health and Human Services CA 94076 American Institute for Cancer Research (Washington, DC) PY - ...
TY - JOUR. T1 - Investigations into the loss of glutathione from lenses in organ culture. AU - Qin, Chuan. AU - Tumminia, Santa J.. AU - Russell, Paul. AU - Rao, P. Vasantha. AU - Zigler, J. Samuel. PY - 1996. Y1 - 1996. N2 - Purpose. To investigate possible causes and implications of the decrease in glutathione concentration in rat lenses during organ culture. Methods. Freshly excised lenses were incubated in modified TC-199 medium. Ellmans Reagent or the GSH-400 assay were used to assay glutathione levels in lenses cultured for different times and under a variety of altered culture conditions. Results. In lenses from young rats the glutathione decrease was not ameliorated by reduction of oxygen tension in the incubator, nor by supplementation of the culture medium with various antioxidants or sulfhydryl compounds, nor with the amino acid precursors of glutathione. Addition of 2-mercaptoethanol stimulated cysteine transport into the lens but had only a modest effect in maintaining the level of ...
Cysteines play important roles in the biochemistry of many proteins. The high reactivity, redox properties, and ability of the free thiol group to coordinate metal ions designate cysteines as the amino acids of choice to form key catalytic components of many enzymes. Also, cysteines readily react with reactive oxygen and nitrogen species to form reversible oxidative thiol modifications. Over the last few years, an increasing number of proteins have been identified that use redox-mediated thiol modifications to modulate their function, activity, or localization. These redox-regulated proteins are central players in numerous important cellular processes. First aim of this study was to discover nitric oxide (NO) sensitive proteins in E. coli, whose redox-mediated functional changes might explain the physiological alterations observed in E. coli cells suffering from NO-stress. To identify E. coli proteins that undergo reversible thiol modifications upon NO-treatment in vivo, I applied a differential ...
In this study we examined whether metabolic stress induced by hypercholesterolemia alone or hyperlipidemia plus hyperglycemia accelerates atherosclerosis and renal injury by promoting thiol oxidative stress in macrophages and increasing the recruitment of macrophages to sites of tissue injury. We found that with each additional level of metabolic stress, macrophage accumulation increased in both atherosclerotic lesions and in kidneys of LDL-R−/− mice. Analysis of the macrophage glutathione reduction potential (Eh) revealed that metabolic stress promotes intracellular thiol oxidation and that oxidation of the macrophage glutathione reduction state correlates with both accelerated macrophage recruitment and increased lesion severity. Macrophage recruitment into MCP-1-loaded Matrigel plugs implanted in these mice was also accelerated with each additional level of metabolic stress, suggesting that increased cellular thiol oxidation induced by metabolic stress amplifies macrophage responses to ...
In order to study the oxidative stress-induced change in intracellular concentration of Ca,SUP,2+,/SUP, ([Ca,SUP,2+,/SUP,]i) and Ca,SUP,2+,/SUP,-induced oxidative stress, effects of hydrogen peroxide and ionomycin, a calcium ionophore, on rat cerebellar neurons were examined using a flow cytometer and fluorescent dyes: fluo-3 for monitoring [Ca,SUP,2+,/SUP,]i; 2, 7-dichlorofluorescin, for reactive oxygen species; and 5-chloromethylfiuorescein, for cellular nonprotein thiols. Oxidative stress induced by hydrogen peroxide dose-dependently increased [Ca,SUP,2+,/SUP,]i and decreased the content of nonprotein thiols. Ionomycin increased oxidative metabolism and decreased the content of nonprotein thiols. Results suggest that oxidative stress induces an increase in [Ca,SUP,2+,/SUP,]j While an increase in [Ca,SUP,2+,/SUP,]i increases oxidative stress in neurons.. ...
Although the biophysical properties of T-channels were first described in sensory neurons (Carbone and Lux, 1984), their function in nociception has only recently been established (Todorovic et al., 2001a; Bourinet et al., 2005; Choi et al., 2007). Indeed, the molecular mechanisms that regulate the function of these channels in pain processing still are not well understood. The major finding of this study is that LA inhibits native and recombinant T-currents by oxidizing specific thiol residues on the extracellular face of the channel. Inhibition of CaV3.2 T-channels and the ensuing decrease in cellular excitability in nociceptive DRG cells may contribute to the documented analgesic properties of LA in vivo. This notion is strongly supported by the finding that local intraplantar injection of LA potently diminished responses to noxious thermal and mechanical stimuli in wild-type mice, but was completely ineffective in CaV3.2 knock-out mice. Importantly, we identified a novel regulatory site on ...
Thiol or sulfhydryl groups are highly reactive functional groups in cellular systems. Molecules carrying thiol groups are mostly derivatives of the amino acid cysteine and are grouped as low molecular weight (LMW)-thiols: coenzyme A (CoA), glutathione (GSH) or bacillithiol (BSH). LMW-thiols can help in the maintenance of the reduced cellular environment as so called redox-buffers. Additionally, they act as co-factors in enzyme reactions or help in the detoxification of reactive oxygen or nitrogen species, electrophilic compounds or thiophilic metalloids (arsenite, tellurite). In proteins from different organisms cysteine is underrepresented compared to other amino acids, but still overtakes diverse roles. It is an important determinant in the tertiary and quaternary structure of proteins. The nucleophilic character of the thiol or thiolate group, respectively, makes cysteine the catalytically active amino acids of different enzymes. As a precursor cysteine participates in the formation of Fe-S ...
This protocol describes how to vary the stiffness of a hydrogel made with a 12.5 mL HyStem® Hydrogel Kit, which is composed of Glycosil (CMHA-S, thiol-modified hyaluronic acid), Gelin-S (Gtn-DTPH, thiol-modified gelatin), Extralink (PEGDA, polyethylene glycol diacrylate), and DG Water (degassed, deionized water).
This protocol describes how to vary the stiffness of a hydrogel made with a 7.5 mL HyStem® Hydrogel Kit, which is composed of Glycosil® (CMHA-S, thiol-modified hyaluronic acid), Gelin-S® (Gtn-DTPH, thiol-modified gelatin), Extralink® (PEGDA, polyethylene glycol diacrylate), and DG Water (degassed, deionized water).
Purchase Thiol Redox Transitions in Cell Signaling, Part A, Volume 473 - 1st Edition. Print Book & E-Book. ISBN 9780123813459, 9780123813466
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., ...
TY - JOUR. T1 - Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals. AU - Nakashima, Izumi. AU - Pu, Mei Yi. AU - Nishizaki, Akira. AU - Rosila, Idris. AU - Ma, Li. AU - Katano, Yoshiaki. AU - Ohkusu, Kozo. AU - Rahman, S. M.Jamshedur. AU - Isobe, Ken Ichi. AU - Hamaguchi, Michinari. AU - Saga, Keisuke. PY - 1994/2/1. Y1 - 1994/2/1. N2 - Cross-linking with specific ligand is a general requirement for ordered activation of cell surface receptors. In this study we demonstrated a novel pathway for disregulated receptor activation through a redox mechanism. Treatment of murine thymocytes or spleen cells with thiol-reactive HgCl2, a known inducer of autoimmune proliferative lymphocyte disorders in rodents, was found to induce tyrosine phosphorylation of several cellular proteins, which was up to 100 times as extensive as that triggered by stimulation with antireceptor antibody or mitogen. Through the cross-linkage by thiol-reactive ...
View Notes - RasMol Assignment 2 from CHEM 101 at Northwestern IA. 4. There are 2 prosthetic groups present in HIV-1 Reverse Transcriptase. 5. There are roughly 24 phenylalanine present. 6. I looked
Ive been gallivanting through a gallimaufry of gaming goals recently, but this Bear cannot get it in gear from group content alone. There have to be soloing goals to grip me as well, yknow? At this point in the expansion lull, what do you do? Just keep scouting Archaeology sites to get those last nine rares?…
Ive been gallivanting through a gallimaufry of gaming goals recently, but this Bear cannot get it in gear from group content alone. There have to be soloing goals to grip me as well, yknow? At this point in the expansion lull, what do you do? Just keep scouting Archaeology sites to get those last nine rares?…
Hospital discharge: the patient, carer and doctor perspective JANUARY 2014 BMA Patient Liaison Group Contents Foreword by Dr Mark Porter, Chair of Council, BMA...3 Foreword by Catherine Macadam, Chair
Nitrous Kit for 48cc/66cc/80cc 2 stroke engines, 49cc 4-stroke engines These nitrous kits are designed to mount directly to your handle bars so that you never h
RedoxDB. A database dedicated to oxidative thiol modifications. The database already includes more than 2,000 proteins for which oxidative modifications, such as disulfides, S-sulfenylation, S-sulfinylation, S-glutathionylation, and S-nitrosylation, have been reported.. ...
|p|Gastec Detector Tubes indicate concentrations directly by way of a calibrated scale printed on the tubes. Gastec detector tubes are used for analysing airborne gases/vapours, as well as pollutants in soil and water.|/p|
I.D. Pavićević, V.B. Jovanović, M.M. Takić, A.Z. Penezić-Romanjuk, J.M. Aćimović, Lj.M. Mandić: Fatty acids binding to human serum albumin: changes of reactivity and glycation level of Cysteine-34 free thiol group with methylglyoxal. Chem Biol Int (2014) 224, 42-50 ...
This paper provides a systems level integration of the molecular events subject to reversible oxidation during IL-4 signal transduction. Code for simulation provided.
Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl ... SNO-vWF; N-Nitroso compounds (e.g., nitrosamines): SIN-1A. *Nitrosyl compounds: Metal nitrosyl complexes: Roussin's black salt ... Nitroso compounds/nitrites: Nitrite (NO−. 2); O-Nitroso compounds (alkyl nitrites): Amyl nitrite (isoamyl nitrite, isopentyl ... Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a ...
Budwig believed sulphydryl compounds were important to cellular metabolism and cellular respiration. Budwig researched the ... theory that a low oxygen environment would develop in the absence of sulphydryl groups and/or fatty acid partners that would ... a researcher at the German Federal Health Office she noted many cancer drugs being evaluated in the 1950s contained sulphydryl ...
Bremer J; Greenberg DM (1961). "Enzymic methylation of foreign sulfhydryl compounds". Biochim. Biophys. Acta. 46 (2): 217-224. ...
Jaffe, Israeli A. (March 1986). "Adverse effects profile of sulfhydryl compounds in man". The American Journal of Medicine. 80 ... which are broadly similar to those of D-penicillamine and other compounds containing active sulfhydryl groups. Its ... In 2016 Imprimis Pharmaceuticals introduced a lower cost version marketed as a compounded drug. Lindell, Å.; Denneberg, T.; ...
"In vitro proteoglycan sulfation derived from sulfhydryl compounds in sulfate transporter chondrodysplasias". Pediatric ...
... is an organosulfur compound containing carboxyl and sulfhydryl functional groups. Its molecular formula is ...
The pattern of resistance and sensitivity correlates with the level of sulfhydryl compounds in the cell. Sulfhydryls are ...
... lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds". Urological ...
The activity of PTGES2 is thought to be increased in the presence of sulfhydryl compounds, in particular dithiothreitol. The ...
... prostaglandins and sulfhydryl compounds". Pharmacology. 54 (4): 193-202. doi:10.1159/000139487. PMID 9211565. Alarcón de la ...
... reacts with primary amines efficiently at pH 7 to 9, creating amidine compounds with a sulfhydryl group. Thus ... It is a thiolating reagent that reacts with primary amine groups, such as those of amino acids, to form sulfhydryl groups. ... 2-Iminothiolane is a cyclic thioimidate compound also known as Traut's reagent. ...
... did not deplete sulfhydryl-group containing compounds. The isopropyl radical formed as a result of the metabolism of iproniazid ... In contrast, the compounds cobalt chloride, piperonyl butoxide and alpha-naphthylisothiocyanate inhibit microsomal enzymes ... Alkylating agents have the capability to bind to chemical groups such as amino, phosphate hydroxyl, imidazole and sulfhydryl ... Rat models and other animal models have shown that cytochrome P450 enzymes convert isopropyl hydrazine to alkylating compounds ...
... of GSH-via a sulfhydryl group-to electrophilic centers on a wide variety of substrates in order to make the compounds more ... The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, ... Because the GST protein has a strong binding affinity for GSH, beads coated with the compound can be added to the protein ... some endogenous compounds, e.g., bilirubin, can inhibit the activity of GSTs. In mammals, GST isoforms have cell specific ...
Organic mercurial compounds, such as methylmercury, have a high affinity for sulfhydryl groups, which causes dysfunction of the ... In 1926, Loewi and E. Navratil deduced that the compound is probably acetylcholine, as vagusstoff and synthetic acetylcholine ... Acetylcholine is synthesized in certain neurons by the enzyme choline acetyltransferase from the compounds choline and acetyl- ... muscarine is a compound found in the mushroom Amanita muscaria; nicotine is found in tobacco. Nicotinic acetylcholine receptors ...
... is an organosulfur compound. It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the ... Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing ... Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. Mesna is a water-soluble ... This conjugation reaction inactivates the urotoxic compounds to harmless metabolites. The metabolites are then excreted in the ...
... compound.[26] This compound is then converted to a mono-methylated arsenic (III) compound using Glutathione S-Transferase Omega ... Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively targeted by arsenite (III) metabolites.[ ... compound, which can be converted to a dimethyl arsenic (III) compound by Glutathione S-Transferase Omega-1 (GTSO1).[26] The ... cacodylic acid is the major As compound[7]. A very unusual composition of organoarsenic compounds was found in deer truffles ( ...
A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types". Journal of Medicinal Chemistry. 29 ( ... and is metabolized in the liver to form the pharmacologically active compound moexiprilat. Formation of moexiprilat is caused ... "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. ...
He pursued biochemical research on the metabolic and developmental roles of sulfhydryl compounds, working initially with ... Rapkine, L. (1938). "Sulfhydryl groups and enzymic oxido-reduction". Biochemical Journal. 32 (10): 1729-1739. doi:10.1042/ ...
... s also describes a class of compounds formally derived from thiophenol itself. All have a sulfhydryl group (-SH) ... The prefix thio- implies a sulfur-containing compound and when used before a root word name for a compound which would normally ... Thiophenol is an organosulfur compound with the formula C6H5SH, sometimes abbreviated as PhSH. This foul-smelling colorless ... There are several methods of synthesis for thiophenol and related compounds, although thiophenol itself is usually purchased ...
Her studies with laboratory animals showed that sulfhydryl compounds may protect against toxicity from x-irradiation and ... alkylating agents by a distribution pattern which causes more of a protective compound to accumulate in the sensitive tissues ...
For example via epoxide hydratase (EH) or via interactions with a sulfhydryl compound, which leads to the formation of a ... Methacrylonitrile (or 2-Methylprop-2-enenitrile), MeAN in short, is a chemical compound that is an unsaturated aliphatic ... "unsaturated compounds formed by a burning cigarette. Anal. Proc. 21, 135 Toxicology and Carcinogenesis Studies of ...
... chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS". ... Pan-assay interference compounds (PAINS) are chemical compounds that often give false positive results in high-throughput ... Baell JB, Holloway GA (April 2010). "New substructure filters for removal of pan assay interference compounds (PAINS) from ... the accuracy of filters with regard to compounds they flag and don't flag has been criticized. Common PAINS include toxoflavin ...
However, the monomethylated compound was shown to be more reactive and more toxic than the inorganic arsenic compounds to human ... Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively targeted by arsenite (III) metabolites. ... This compound is then converted to a mono-methylated arsenic (III) compound using Glutathione S-Transferase Omega-1 (GSTO1). ... Representative organoarsenic compounds found in nature. Arsenobetaine, one of the most common arsenic compound in nature. Also ...
He settled on using a sulfhydryl group which binds strongly to zinc. Ondetti had discovered Captopril, an ACE inhibitor with ... U.S. Patent 3,740,385 "N-Terminal Derivatives of Secretin", filed May 1970, issued June 1973 U.S. Patent 4,199,512 "Compounds ... "Compounds for alleviating angiotensin related hypertension", filed February 1978, issued July 1982 U.S. Patent 4,722,810 " ... His group tried thousands of compounds from the Squibb library, but none yielded satisfying results. After reading literature ...
The mechanism of action of an isolated compound can also be misidentified if a single assay is used because some compounds ... For example, the sulfhydryl-scavenging assay used to detect histone acetyltransferase inhibition can give a false positive ... to include reference compounds (ie. pure chemical compounds for which accurate bioactivity and toxicity data are available), to ... Using just a single assay, especially a single in vitro assay, gives a very incomplete picture of an extract or compound's ...
... is an organic compound with the molecular formula C3H8S. It belongs to the group of thiols. It is a colorless ... except that sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group in the molecule. ... Propanethiol is chemically classified among the thiols, which are organic compounds with molecular formulas and structural ...
... is a very noxious and caustic chemical compound, and at sufficiently high concentrations, it produces serious ... except that sulfur-containing sulfhydryl group (-SH) replaces the oxygen-containing hydroxyl group (-OH) in the molecule. 1- ... which are organic compounds with molecular formulas and structural formulas similar to alcohols, ...
Organic mercurial compounds, such as methylmercury, have a high affinity for sulfhydryl groups, which causes dysfunction of the ... Acetylcholine is synthesized in certain neurons by the enzyme choline acetyltransferase from the compounds choline and acetyl- ... muscarine is a compound found in the mushroom Amanita muscaria; nicotine is found in tobacco. ...
... reactive iodacetyl function group which labels sulfhydryl-(-SH) groups (iodoTMT) and (3) reactive alkoxyamine functional group ... which provides covalent labeling of carbonyl-containing compounds (aminoxyTMT). A key benefit of isobaric labeling over other ...
Phosgene directly reacts with amine, sulfhydryl, and alcohol groups, adversely affecting cell macromolecules and metabolism. ... is also used as an industrial reagent and building block in synthesis of pharmaceuticals and other organic compounds. Because ...
... is the anion [OSCN]− and the conjugate base of hypothiocyanous acid (HOSCN). It is an organic compound part of ... Thomas EL, Aune TM (May 1978). "Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl ... Initially, this particular lactoperoxidase-catalyzed compound was originally discovered while viewing the specific environment ... against bacteria is reported to be caused by sulfhydryls (SH) oxidation. The oxidation of -SH groups in the bacterial ...
... was developed from this peptide after it was found via QSAR-based modification that the terminal sulfhydryl moiety of ... is consistent with the observation that animal screening models indicate putative antidepressant activity for this compound, ...
Current Bioactive Compounds. 3 (1): 37-66. doi:10.1016/j.jallcom.2006.06.070.. CS1 maint: Multiple names: authors list (link) ... sulfhydryl, and phosphate groups in biologically important molecules.[36] Non-classical alkylating agents include procarbazine ... an arsenic compound discovered in 1907 and used to treat syphilis.[146] This was later followed by sulfonamides (sulfa drugs) ... Derivatives of these compounds include epirubicin and idarubicin. Other clinically used drugs in the anthracyline group are ...
... s are compounds that inhibit oxidation. Oxidation is a chemical reaction that can produce free radicals, thereby ... Besides ascorbate, medically important conditional pro-oxidants include uric acid and sulfhydryl amino acids such as ... Some compounds contribute to antioxidant defense by chelating transition metals and preventing them from catalyzing the ... Examples of bioactive antioxidant compounds[edit]. Antioxidants are classified into two broad divisions, depending on whether ...
A small proportion of aldophosphamide freely diffuses into cells, where it is decomposed into two compounds, phosphoramide ... a sulfhydryl donor which binds and detoxifies acrolein.[21][22] Intermittent dosing of cyclophosphamide decreases cumulative ... and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis.[18] ... Brock and his team synthesised and screened more than 1,000 candidate oxazaphosphorine compounds.[47] They converted the base ...
This compound is sold as a dietary supplement, and used as an antidote in cases of acetaminophen overdose.[29] ... The nucleophilic sulfhydryl group allows cysteine to conjugate to other groups, e.g., in prenylation. Ubiquitin ligases ... The cysteine sulfhydryl group is nucleophilic and easily oxidized. The reactivity is enhanced when the thiol is ionized, and ... Disulfide bonds in proteins are formed by oxidation of the sulfhydryl group of cysteine residues. The other sulfur-containing ...
"L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005 ... The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. ... US patent 3091569, Aaron Leonard Sheffner, "Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus ...
The acetyl group (indicated in blue in the structural diagram on the right) of acetyl-CoA is linked to the sulfhydryl ... Chemical articles with multiple compound IDs. *Multiple chemicals in an infobox that need indexing ...
For elution, an excess amount of a compound able to act as a metal ion ligand, such as imidazole, is used. GST has an affinity ... This cysteine residue contains a sulfhydryl functional group which allows the peptide to be easily conjugated to a carrier ... The higher affinity a compound has towards the target, the longer it remains in the separation unit, and this will be expressed ... The affinity measure and ranking of affinity can be achieved by processing the obtained retention times of analyzed compounds. ...
Reaction with protein sulfhydryl groupsEdit. Knox et al.[29] first noted that HClO is a sulfhydryl inhibitor that, in ... Its compounds will be called hypochlorites.) *^ Unangst, P. C. "Hypochlorous Acid" in Encyclopedia of Reagents for Organic ... some sulfhydryl function can be restored.[28] One sulfhydryl-containing amino acid can scavenge up to four molecules of HOCl.[ ... The resulting compound is a chlorohydrin.[18] The polar chlorine disrupts lipid bilayers and could increase permeability.[19] ...
Nitroso compound Nitroso. RNO nitroso- (Nitrosyl-). Nitrosobenzene Oxime Oxime. RCH=NOH Oxime Acetone oxime. (2-Propanone oxime ... Sulfhydryl RSH sulfanyl-. (-SH) -thiol Ethanethiol Sulfide. (Thioether) Sulfide RSR' substituent sulfanyl-. (-SR') di( ... Azo compound Azo. (Diimide) RN2R' azo-. -diazene Methyl orange. (p-dimethylamino-azobenzenesulfonic acid) ... Compounds that contain C-O bonds each possess differing reactivity based upon the location and hybridization of the C-O bond, ...
"L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005 ... The thiol (sulfhydryl) group confers antioxidant effects and is able to reduce free radicals. ... "The Overlooked Compound That Saves Lives". Retrieved 8 July 2013.. Julius Goepp, MD. Published in Life Extension, May 2010, ...
... but such compounds are still used in industrial settings.[20] Organic lead compounds, which cross the skin and respiratory ... The primary cause of lead's toxicity is its interference with a variety of enzymes because it binds to sulfhydryl groups found ... Some lead compounds are colorful and are used widely in paints,[93] and lead paint is a major route of lead exposure in ... Grant, L.D. (2009). "Lead and compounds". In Lippmann, M. Environmental Toxicants: Human Exposures and Their Health Effects ( ...
Glutathione (GSH) accounts for more than 90% of total intracellular non-protein sulfhydryl and is critical in a variety of ... normal cell GSH levels has also been investigated as a means to reduce the toxicity associated with a wide variety of compounds ...
CompoundsEdit. See also: Category:Sulfur compounds.. Common oxidation states of sulfur range from −2 to +6. Sulfur forms stable ... Reduced glutathione, a sulfur-containing tripeptide, is a reducing agent through its sulfhydryl (-SH) moiety derived from ... An important S-N compound is the cage tetrasulfur tetranitride (S4N4). Heating this compound gives polymeric sulfur nitride (( ... 2005). "Magnetic susceptibility of the elements and inorganic compounds". CRC Handbook of Chemistry and Physics (PDF) (86th ed ...
... s are compounds that inhibit oxidation. Oxidation is a chemical reaction that can produce free radicals, thereby ... Besides ascorbate, medically important conditional pro-oxidants include uric acid and sulfhydryl amino acids such as ... Some compounds contribute to antioxidant defense by chelating transition metals and preventing them from catalyzing the ... Hiner AN, Raven EL, Thorneley RN, García-Cánovas F, Rodríguez-López JN (July 2002). "Mechanisms of compound I formation in heme ...
1989) "4-Chlorination of Electron-Rich Benzenoid Compounds: 2,4-Dichloromethoxybenzene". Org. Synth. 67; Coll. Vol. 8: 167.. ... Jacangelo, J. G.; Olivieri, V. P.; Kawata, K. (1987). "Oxidation of sulfhydryl groups by monochloramine". Water Res. 21: 1339- ... "Chloramine", PubChem Compound Database, National Center for Biotechnology Information, diakses tanggal July 19, 2017. Parameter ...
Ellman GL (1959). "Tissue sulfhydryl groups". Arch. Biochem. Biophys. 82 (1): 70-7. doi:10.1016/0003-9861(59)90090-6. PMID ... Thiols react with this compound, cleaving the disulfide bond to give 2-nitro-5-thiobenzoate (TNB−), which ionizes to the TNB2− ... Riener CK, Kada G, Gruber HJ (2002). "Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'- ... "Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4′-dithiodipyridine". Analytical and Bioanalytical ...
... is also used to refer to compounds that contain two sulfide (S2−) centers. The compound carbon disulfide, CS2 is ... Disulfide bonds are usually formed from the oxidation of sulfhydryl (−SH) groups, especially in biological contexts.[3] The ... Related compounds[edit]. Thiosulfoxides are orthogonally isomeric with disulfides, having the second sulfur branching from the ... Compounds with three sulfur atoms, such as CH3S−S−SCH3, are called trisulfides, or trisulfide bonds. ...
This compound is a potent inhibitor of cGMP specific phosphodiesterase type 5, the enzyme that degrades the signalling molecule ... The residues modified are those with side chains containing nucleophiles such as hydroxyl or sulfhydryl groups; these include ... In the past the only way to discover these new inhibitors was by trial and error: screening huge libraries of compounds against ... Cohen, J.A.; Oosterbaan, R.A.; Berends, F. (1967). "[81] Organophosphorus compounds". Enzyme Structure. Methods in Enzymology. ...
In burning, lead and its compounds are exposed into air, soil, and water. Lead can have different effects on the body and ... Arsenic, "is a protoplastic poison since it affects primarily the sulphydryl group of cells causing malfunctioning of cell ... The three forms include, organic compounds, metallic elements and inorganic salts. As stated above, they are present in water ...
... (/ˈθaɪɔːl/, /ˈθaɪɒl/)[1] is an organosulfur compound that contains a carbon-bonded sulfhydryl (-SH) group (where R ... The spray of skunks consists mainly of low-molecular-weight thiols and derivatives.[9][10][11][12][13] These compounds are ... Sulfhydryl groups in the active site of an enzyme can form noncovalent bonds with the enzyme's substrate as well, contributing ... Organolithium compounds and Grignard reagents react with sulfur to give the thiolates, which are readily hydrolyzed:[24] ...
... it can be combined with other compounds and enzymes and create reactive oxidants, as well as oxidize other substrates. Bovine ... but it can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. The ...
Cysteine, in a concentration of 850 mgkg body weight administered intravenously 10 min prior to total body irradiation with 880 r, counteracted the inhibiting effect of x-rays on nucleic acid synthesis in the intestinal mucosa of the albino rat. Immediately after irradiation the rats received 20-50 micro-c P to the power of 32 intraperitoneally. The small intestine was used for determining the inorganic tissue P and desoxypentose nucleic acid P and their specific activities.
The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use ... Rights & permissionsfor article The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective ...
Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl ... SNO-vWF; N-Nitroso compounds (e.g., nitrosamines): SIN-1A. *Nitrosyl compounds: Metal nitrosyl complexes: Roussins black salt ... Nitroso compounds/nitrites: Nitrite (NO−. 2); O-Nitroso compounds (alkyl nitrites): Amyl nitrite (isoamyl nitrite, isopentyl ... Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a ...
The seeds contain around 1.5 mmol of thiol/sulfhydryl compounds per 100 g of dried seeds. The contents of the sulfhydryl ... The seeds contain around 1.5 mmol of thiol/sulfhydryl compounds per 100 g of dried seeds. The contents of the sulfhydryl ... The seeds contain around 1.5 mmol of thiol/sulfhydryl compounds per 100 g of dried seeds. The contents of the sulfhydryl ... The seeds contain around 1.5 mmol of thiol/sulfhydryl compounds per 100 g of dried seeds. The contents of the sulfhydryl ...
We report that structurally distinct small molecule NRF2 activators, all of which react with sulfhydryl groups but differ in ... Sulfhydryl Compounds / chemistry* * Sulfhydryl Compounds / pharmacology * Transcription Factors / antagonists & inhibitors * ... HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway Chem Biol. 2011 Nov 23;18(11 ... We report that structurally distinct small molecule NRF2 activators, all of which react with sulfhydryl groups but differ in ...
India to investigate the effects of exogenous sulphydryl (-SH) compounds (thioglycolic acid and thiourea) on... ... Sahu MP, Solanki NS (1991) Role of sulphydryl compounds in improving dry matter partitioning and grain production of maize (Zea ... Antioxidant enzymes Gas exchange parameters Sulphydryl compounds Water relation Vigna aconitifolia Yield ... India to investigate the effects of exogenous sulphydryl (-SH) compounds (thioglycolic acid and thiourea) on the water relation ...
Sulfhydryl compounds PENTAERYTHRITOL TETRA(3-MERCAPTOPROPIONATE) Categories:Compound Amino Acid Powder Telephone:0532-86898076 ...
Sulfhydryl Compounds as Thermosensitizers R. D. Issels. Pages 22-27 * Therapeutic Benefit from Combined Heat and Radiation ...
Sulfhydryl Compounds / adverse effects * Sulfhydryl Compounds / therapeutic use* * Triglycerides / blood Substances * ...
Sulfhydryl Compounds. *Sulfur Compounds. more. CAS number. 17528-66-4. Drug Targets. Name. Target Sequence. Pharmacological ...
... hydrophobic interaction compounds (e.g., C4, C8 and C18 compounds); sulfhydryls; heparins; inherently active surfaces (e.g., ... Such materials include: reverse phase materials, e.g., C8 or C18 compound coated particles; ion-exchange materials; affinity ... naturally occurring compounds such as peptides and nucleic acids, proteins, glycoproteins, organic and inorganic ions, steroids ...
Objective and design To investigate the role of non-protein sulfhydryl groups (NP-SH) and leukocyte adhesion in the protective ... Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: role of endogenous sulfhydryls in the ... Sulfhydryl compounds may mediate gastric cytoprotection. Science. 1981;214(4517):200-2.PubMedCrossRefGoogle Scholar ... To investigate the role of non-protein sulfhydryl groups (NP-SH) and leukocyte adhesion in the protective effect of ...
This suggests that additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, SSZ and MTX could be a ... Additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, sulfasalazine and methotrexate in the ... Additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, sulfasalazine and methotrexate in the ... combination therapy of a low dose of sulfhydryl compounds inverted question markD-penicillamine, bucillamine or tiopronin ...
Involvement of Glutathione, Sulfhydryl Compounds, Nitric Oxide, Vasoactive Intestinal Peptide, and Heat-Shock Protein-70 in the ... The gastric ulcer area of rats treated with the sulfhydryl compound blocker was decreased, but the ulcer area of rats treated ... These findings suggest that sulfhydryl compounds and heat-shock protein-70, but not nitric oxide, glutathione, or vasoactive ... and nonprotein sulfhydryl compounds in the gastroprotective effect was determined in male Wistar rats. The minimum inhibitory ...
Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP in human peripheral lymphocytes. / Wedner, H. J.; ... Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP in human peripheral lymphocytes. Cellular Immunology. ... Wedner, H. J. ; Chaplin, D. D. ; Parker, C. W. / Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP in ... Wedner, H. J., Chaplin, D. D., & Parker, C. W. (1977). Sulfhydryl compounds potentiate lectin induced increases in cyclic AMP ...
Alteration of lymphocyte response by sulfhydryl and disulfide compounds.. Merryman PF, Nowakowski J, Jaffe IA. ...
A well-established sulfhydryl compound of high mucolytic activity is N-acetylcysteine, which is used as an expectorant in ... Another potent sulfhydryl compound is dithiothreitol. In ileum and proximal colon, this agent increased the absorption and ... Sulfhydryl compounds display more potent hydrolytic activity than detergents by cleaving disulfide bonds which connect mucus ... Detergents, sulfhydryl compounds, and mucolytic enzymes are reported to display mucolytic activity, thereby improving peptide ...
Bremer J; Greenberg DM (1961). "Enzymic methylation of foreign sulfhydryl compounds". Biochim. Biophys. Acta. 46 (2): 217-224. ...
0/(10)-shogaol; 0/(8)-shogaol; 0/Antineoplastic Agents, Phytogenic; 0/Catechols; 0/Sulfhydryl Compounds; 6JKA7MAH9C/Guaiacol; ...
Organometallic Compounds / diagnostic use*. Succimer / diagnostic use*. Sulfhydryl Compounds / diagnostic use*. Swine. Swine, ... 0/Organometallic Compounds; 0/Sulfhydryl Compounds; 304-55-2/Succimer; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid; ...
Finally, sulfhydryl-reactive -lactams were developed as a new class of LCAT activators. In conclusion, compound A activates ... 0 (Enzyme Activators); 0 (Sulfhydryl Compounds); EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase); K848JZ4886 ( ... Molecular modeling was performed to gain insight into the effects of compound A on LCAT structure and activity. Compound A ... Functional groups important for LCAT activation by compound A were identified by testing compound A derivatives. ...
0 (Azides); 0 (Drug Carriers); 0 (Nanocapsules); 0 (Nucleic Acids); 0 (Peptides); 0 (Sulfhydryl Compounds); 7440-57-5 (Gold); ... Polycyclic Compounds); 0 (Vitamins); 0 (platencin); 30KYC7MIAI (Aspartic Acid); PJY633525U (Adamantane); Q3DQ78KOFY ( ...
2007) Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am J Physiol Cell Physiol 292:C2161-C2174. ... We found that H2O2 decreased ASIC1a current amplitude with a time course similar to that reported for the oxidizing compound ... to block reactive sulfhydryl groups and then analyzed using non-reducing conditions. Interestingly, these conditions revealed a ... then biotinylated and lysed in the presence of 30 mM NEM to block all reactive sulfhydryl groups. Surface protein was pulled ...
... was induced for evaluation of GM adaptive response and effects of testing the therapeutic potential of H2S-releasing compounds ... was induced for evaluation GM adaptive response and effects of testing the therapeutic potential of H2S-releasing compounds ( ... Our data could be explained by previous results of several scientific groups that show the role of sulfhydryl compounds in ... Szabo, S., Trier, J. S., Frankel, P. W. (1981). Sulfhydryl compounds may mediate gastric cytoprotection. Science 214 (4517), ...
It contains ingredients that reduces oxidation stress, namely; polyphenol and sulfhydryl compounds. The recommended dosage is ... This compound should be considered to be a form of treatment for osteoarthritis. It should be noted that when taking this, or ... This compound is involved in the natural cushioning of the joints, which means that damage and pain can result from a lack of ... This compound is found naturally occurring in the joints of the body. It is important as a precursor and stimulant of the ...
It contains ingredients that reduces oxidation stress, namely; polyphenol and sulfhydryl compounds. The recommended dosage is ... It possesses bioactive compounds from its sterols. Guggul has been used to treat obesity, acne, inflammation and hypolidemia. ... The recent results were reflective of findings from two animal studies that examined the compounds efficacy in improving ... It even blocks oxidation of low-density lipo-proteins thus enabling the breakdown of cholesterol into manageable compounds. ...
Buffers should be free of any sulfhydryl containing compounds.. Maleimides react specifically with --SH groups at slightly ... The first sulfhydryl reactive-protein prepared in the amine reaction step is mixed with the sulfhydryl-containing protein under ... The protein should not contain free sulfhydryl groups. In cases where both proteins to be conjugated contain free sulfhydryl ... or pyridyl disulfides must contain a free sulfhydryl, usually from a cysteine residue. Free sulfhydryls can be generated by ...
Sulfhydryl Compounds · Support, Non-U.S. Govt · Support, U.S. Govt, P.H.S. · Thrombosis · Thrombospondins ... It is concluded that for the development of novel therapeutic compounds based on chicken cathelicidin-2 d-amino acid ... an acid-base catalyst in facilitating the reaction between the peroxidase and hydrogen peroxide with the formation of Compound ...
Chemicals/CAS: endonuclease, 9055-11-2; DNA, 9007-49-2; Endonucleases, EC 3.1.-; Sulfhydryl Compounds ... Although common chemical-analytical methods did not detect any anabolic steroids in these samples, the presence of compounds ... Detection of hormonal anabolic compounds in calf urine and unverified growth-promoting preparations : application of the AR-LUX ... Due to continuing improvements in analytical techniques, very low detection limits for individual compounds have been achieved ...
  • Background: Two precolumn fluorescence derivatization procedures by two different sulfhydryl-reactive iodoacetyl reagents were established to measure simultaneously glutathione and l-ergothioneine in human whole blood by means of CE and LC. (edu.au)
  • Both soluble and refolded recombinant tubulins of malaria were examined in a drugtubulin interaction study using sulfhydryl reactivity and fluorescence quenching techniques. (edu.au)
  • In addition, mammalian tubulin was also used to determine the potential toxicity effects of these compounds. (edu.au)
  • In oxidatively damaged mitochondria, lipid peroxidation was inhibited significantly by isovitexin whereas vitexin prevented decrease in protein sulphydryl content more effectively. (antiox.org)
  • The sulfhydryl groups, normally involved in metal binding, render the protein particularly sensitive towards oxidation. (echemi.com)
  • Known tubulin inhibitors (colchicine, tubulozole-c and vinblastine) and novel synthetic compounds (CCWA-110, 239 and 443) were used as the drug compounds to determine the dynamics and kinetics of the interactions. (edu.au)
  • Two synthetic compounds (CCWA-239 and 443) that have previously tested positive against P. falciparum in vitro were found to bind effectively with all three tubulin monomers, while displaying low binding interactions with the mammalian tubulin, thus indicating that these compounds have potential antimalarial activity. (edu.au)
  • Medicinal scientific experts are centered around medication disclosure and advancement and are concerned about the separation of medicinal agents found in plants, and also the production of new synthetic drug compounds . (edelweisspublications.com)
  • Although there is no hard-core evidence of drug resistance shown on the new antimalarial compounds (artemisinin and artesunate), induced resistant studies in animal models have demonstrated that the malarial parasites have capabilities to develop resistance to these compounds (Ittarat et al. (edu.au)
  • In the IUPAC system, a compound containing two hydroxyl groups is named as a diol, one containing three hydroxyl groups as a triol, and so forth. (slideserve.com)
  • We commonly refer to compounds containing two hydroxyl groups on adjacent carbons as glycols. (slideserve.com)
  • The presence of 33% hydrazide compound in the initial monomer mixture appeared to be sufficient to achieve the maximum content of active groups. (cenicriviroc.info)
  • Methods for determining the affinity of a compound such as the further targeting moiety to a or the target are known to the one skilled in the art and, for example described in Schier et al. (kylefoster.me)
  • There is great interest in the beneficial effects of marine functional compounds such as omega-3 polyunsaturated fatty acids. (matisiceland.org)
  • These compounds protected HepG2 cells to the same extent against hydrogen peroxide induced oxidative insult by reducing intracellular ROS and modulating the levels of antioxidant enzymes. (antiox.org)
  • Arsenic is a protoplastic poison due to its effect on sulphydryl group of cells interfering with cells enzymes, cell respiration and mitosis. (pbaforum.cz)
  • Pulse radiolysis studies revealed good antioxidant activity of both compounds against short-lived radicals and affected the formation and decay of the 2-dG transient species to the same extent. (antiox.org)
  • Similarities were observed with other published reports in the binding of colchicine with the recombinant tubulins, hence confirming proposed binding sites of this compound on the Plasmodium recombinant tubulins. (edu.au)