AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
SulfamethoxazoleTrimethoprimTrimethoprim-Sulfamethoxazole CombinationDapsoneAnti-Infective AgentsAnti-Bacterial AgentsMicrobial Sensitivity TestsDrug HypersensitivityPneumonia, PneumocystisTrimethoprim ResistanceSulfisoxazoleDrug Resistance, BacterialDrug Resistance, Multiple, BacterialIntegronsDrug CombinationsPneumocystis jiroveciiPentamidineTropherymaUrinary Tract InfectionsStenotrophomonas maltophiliaSulfadiazineSulfamethoxypyridazineDihydropteroate Synthase4-Aminobenzoic AcidNocardia InfectionsDrug Resistance, MicrobialWhipple DiseaseHaptensDrug SynergismEscherichia coli InfectionsShigella sonneiNocardiaAnti-Infective Agents, UrinaryMegaloblastsFolic Acid AntagonistsDrug EruptionsPneumocystisVibrio cholerae O1ShigellaCiprofloxacinHydroxylaminesSalmonella entericaEnterobacteriaceaeSalmonellaEscherichia coliRifampinElectrophoresis, Gel, Pulsed-FieldNalidixic AcidTabletsCholeraSulfonamidesGram-Negative Bacterial InfectionsEthambutol
Sulfamethoxazole
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
Trimethoprim
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Trimethoprim-Sulfamethoxazole Combination
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
Dapsone
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Anti-Infective Agents
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Drug Hypersensitivity
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Pneumonia, Pneumocystis
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
Trimethoprim Resistance
Nonsusceptibility of bacteria to the action of TRIMETHOPRIM.
Sulfisoxazole
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
Drug Resistance, Bacterial
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Drug Resistance, Multiple, Bacterial
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Integrons
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.
Drug Combinations
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Pneumocystis jirovecii
A species of PNEUMOCYSTIS infecting humans and causing PNEUMOCYSTIS PNEUMONIA. It also occasionally causes extrapulmonary disease in immunocompromised patients. Its former name was Pneumocystis carinii f. sp. hominis.
Pentamidine
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Tropheryma
A genus of gram-positive bacteria in the family Cellulomonadaceae.
Urinary Tract Infections
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
Stenotrophomonas maltophilia
A species of STENOTROPHOMONAS, formerly called Xanthomonas maltophilia, which reduces nitrate. It is a cause of hospital-acquired ocular and lung infections, especially in those patients with cystic fibrosis and those who are immunosuppressed.
Sulfadiazine
One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Sulfamethoxypyridazine
A sulfanilamide antibacterial agent.
Dihydropteroate Synthase
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
4-Aminobenzoic Acid
An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
Nocardia Infections
Infections with bacteria of the genus NOCARDIA.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Whipple Disease
A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
Haptens
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
Drug Synergism
The action of a drug in promoting or enhancing the effectiveness of another drug.
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.
Shigella sonnei
A lactose-fermenting bacterium causing dysentery.
Nocardia
A genus of gram-positive, aerobic bacteria whose species are widely distributed and are abundant in soil. Some strains are pathogenic opportunists for humans and animals.
Anti-Infective Agents, Urinary
Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
Megaloblasts
Red blood cell precursors, corresponding to ERYTHROBLASTS, that are larger than normal, usually resulting from a FOLIC ACID DEFICIENCY or VITAMIN B 12 DEFICIENCY.
Folic Acid Antagonists
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Drug Eruptions
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Pneumocystis
A genus of ascomycetous FUNGI, family Pneumocystidaceae, order Pneumocystidales. It includes various host-specific species causing PNEUMOCYSTIS PNEUMONIA in humans and other MAMMALS.
Vibrio cholerae O1
Strains of VIBRIO CHOLERAE containing O ANTIGENS group 1. All are CHOLERA-causing strains (serotypes). There are two biovars (biotypes): cholerae and eltor (El Tor).
Shigella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that ferments sugar without gas production. Its organisms are intestinal pathogens of man and other primates and cause bacillary dysentery (DYSENTERY, BACILLARY).
Ciprofloxacin
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Hydroxylamines
Organic compounds that contain the (-NH2OH) radical.
Salmonella enterica
A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Salmonella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Rifampin
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Electrophoresis, Gel, Pulsed-Field
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Nalidixic Acid
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
Tablets
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Cholera
An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
Sulfonamides
A group of compounds that contain the structure SO2NH2.
Gram-Negative Bacterial Infections
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
Ethambutol
An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)

Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: implications for differences in adverse drug reactions. (1/488)

Differences in the incidence of adverse drug reactions to trimethoprim-sulfamethoxazole and dapsone may result from differences in the formation, disposition, toxicity, and/or detoxification of their hydroxylamine metabolites. In this study, we examine whether differences in the biochemical processing of sulfamethoxazole hydroxylamine (SMX-NOH) and dapsone hydroxylamine (DDS-NOH) by erythrocytes [red blood cells (RBCs)] contribute to this differential incidence. The methemoglobin (MetHgb)-forming capacity of both metabolites was compared after a 60-min incubation with washed RBCs from four healthy human volunteers. DDS-NOH was significantly more potent (P =.004) but equally efficacious with SMX-NOH in its ability to form MetHgb. The elimination of potential differences in disposition by lysing RBCs did not change the MetHgb-forming potency of either hydroxylamine. At pharmacologically relevant concentrations, greater reduction to the parent amine occurred with DDS-NOH. Maintenance of MetHgb-forming potency was dependent on recycling with glutathione, but no difference in cycling efficiency was observed between DDS-NOH and SMX-NOH. In contrast, the pharmacodynamics of hydroxylamine-induced MetHgb formation were not changed by pretreatment with the glucose 6-phosphate dehydrogenase inhibitor epiandrosterone or by compounds that alter normal antioxidant enzyme activity. Methylene blue, which stimulates NADPH-dependent MetHgb reductase activity, decreased MetHgb levels but did not alter the differential potency of these hydroxylamines. DDS-NOH was also significantly more potent when incubated with purified human hemoglobin A0. Collectively, these data suggest that the inherently greater reactivity of DDS-NOH with hemoglobin, the greater conversion of DDS-NOH to its parent amine, and potential differences in disposition of hydroxylamine metabolites may contribute to the preferential development of dapsone-induced hemotoxicity and sulfamethoxazole-induced hypersensitivity reactions.  (+info)

Renal stones and urinary infection: a study of antibiotic treatment. (2/488)

Twenty-two patients in whom renal calculi and urinary infection were closely associated were studied over two to five years. Four patients had previously had stones surgically removed, and five underwent pyelolithotomy during the course of the study. Urinary infection was treated with an appropriate antibacterial agent, and treatment was followed by long-term prophylaxis, usually with cotrimoxazole. A sterile urine was maintained for long periods in all these patients. In four patients, however, apparent stone growth occurred while the urine was sterile. On entering the study 21 of the 22 patients complained of symptoms. After treatment 19 of the 20 patients who were still attending were symptom-free. Six of the 22 patients entered the study with raised levels of serum creatinine; levels fell in four and remained raised in two. This antibacterial regimen, either alone or after surgery, will usually relieve symptoms and may prevent deterioration of renal function.  (+info)

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. (3/488)

1. Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity. We have therefore examined the cellular metabolism, disposition and conjugation of SMX and its metabolites in vitro. 2. Flow cytometry revealed binding of N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX, but not of SMX itself, to the surface of viable white blood cells. Cellular haptenation by SMX-NO was reduced by exogenous glutathione (GSH). 3. SMX-NHOH and SMX-NO were rapidly reduced back to the parent compound by cysteine (CYS), GSH, human peripheral blood cells and plasma, suggesting that this is an important and ubiquitous bioinactivation mechanism. 4. Fluorescence HPLC showed that SMX-NHOH and SMX-NO depleted CYS and GSH in buffer, and to a lesser extent, in cells and plasma. 5. Neutrophil apoptosis and inhibition of neutrophil function were induced at lower concentrations of SMX-NHOH and SMX-NO than those inducing loss of membrane viability, with SMX having no effect. Lymphocytes were significantly (P<0.05) more sensitive to the direct cytotoxic effects of SMX-NO than neutrophils. 6. Partitioning of SMX-NHOH into red blood cells was significantly (P<0.05) lower than with the hydroxylamine of dapsone. 7. Our results suggest that the balance between oxidation of SMX to its toxic metabolites and their reduction is an important protective cellular mechanism. If an imbalance exists, haptenation of the toxic metabolites to bodily proteins including the surface of viable cells can occur, and may result in drug hypersensitivity.  (+info)

Multisite reproducibility of results obtained by the broth microdilution method for susceptibility testing of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum. (4/488)

A multicenter study was conducted to assess the interlaboratory reproducibility of broth microdilution testing of the more common rapidly growing pathogenic mycobacteria. Ten isolates (four Mycobacterium fortuitum group, three Mycobacterium abscessus, and three Mycobacterium chelonae isolates) were tested against amikacin, cefoxitin, ciprofloxacin, clarithromycin, doxycycline, imipenem, sulfamethoxazole, and tobramycin (M. chelonae only) in four laboratories. At each site, isolates were tested three times on each of three separate days (nine testing events per isolate) with a common lot of microdilution trays. Agreement among MICs (i.e., mode +/- 1 twofold dilution) varied considerably for the different drug-isolate combinations and overall was best for cefoxitin (91.7 and 97.2% for one isolate each and 100% for all others), followed by doxycycline, amikacin, and ciprofloxacin. Agreement based on the interpretive category, using currently suggested breakpoints, also varied and overall was best for doxycycline (97.2% for one isolate and 100% for the rest), followed by ciprofloxacin and clarithromycin. Reproducibility among MICs and agreement by interpretive category was most variable for imipenem. Based on results reported from the individual sites, it appears that inexperience contributed significantly to the wide range of MICs of several drugs, especially clarithromycin, ciprofloxacin, and sulfamethoxazole. New interpretive guidelines are presented for the testing of M. fortuitum against clarithromycin; M. abscessus and M. chelonae against the aminoglycosides; and all three species against cefoxitin, doxycycline, and imipenem.  (+info)

Pharmacokinetics and efficacy of trimethoprim-sulfamethoxazole in the treatment of gastroenteritis in children. (5/488)

In vitro studies indicates that the constitutents of the drug combination co-trimoxazole are synergistic against Salmonella and effective against shigella isolated from children ill with gastroenteritis. The drug is well absorbed in children with gastroenteritis due to a variety of causes and is distributed, excreted and metabolized in a manner similar to that seen in normal adult volunteers. The drug is tolerated well by children with gastroenteritis even in very high dosages. Despite its in vitro and pharmacokinetic advantages, co-trimoxazole was not any more efficient than any other durg or no therapy in the treatment of salmonella gastroenteritis; it seems to have a role, however, in the treatment of typhoid fever and may be life-saving in patients infected with ampicillin- and chloramphenical-resistant strains. It is also effective in the treatment of shigella gastroenteritis and is recommended where ampicillin-resistant strains are encountered. Its potential usefulenss for the treatment of other bacterial causes of gastroenteritis in children must be evaluated by further controlled therapeutic trials.  (+info)

Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. (6/488)

Treatment with sulfonamide antibiotics in HIV-infected patients is associated with a high incidence (> 40%) of adverse drug events, including severe hypersensitivity reactions. Sulfonamide reactive metabolites have been implicated in the pathogenesis of these adverse reactions. Sulfamethoxazole hydroxylamine (SMX-HA) induces lymphocyte toxicity and suppression of proliferation in vitro; the mechanism(s) of these immunomodulatory effects remain unknown. We investigated the cytotoxicity of SMX-HA via apoptosis on human peripheral blood mononuclear cells and purified cell subpopulations in vitro. CD19(+), CD4(+), and CD8(+) cells were isolated from human peripheral blood by positive selection of cell surface molecules by magnetic bead separation. SMX-HA induced significant CD8(+) cell death (67 +/- 7%) at 100 microM SMX-HA, with only minimal CD4(+) cell death (8 +/- 4%). No significant subpopulation toxicity was shown when incubated with parent drug (SMX). Flow cytometry measuring phosphatidylserine externalization 24 h after treatment with 100 microM and 400 microM SMX-HA revealed 14.1 +/- 0.7% and 25. 6 +/- 4.2% annexin-positive cells, respectively, compared to 3.7 +/- 1.2% in control PBMCs treated with 400 microM SMX. Internucleosomal DNA fragmentation was observed in quiescent and stimulated PBMCs 48 h after incubation with SMX-HA. Our data show that CD8(+) cells are highly susceptible to the toxic effects of SMX-HA through enhanced cell death by apoptosis.  (+info)

Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals? (7/488)

Hypersensitivity (HS) reactions to sulfonamides and sulfones continue to limit their use in human immunodeficiency virus (HIV)-infected individuals. In vitro cytotoxicity of hydroxylamine metabolites toward peripheral blood mononuclear cells (PBMCs) has been proposed as a marker for these HS reactions. To test the validity of this in vitro system, we determined the selective susceptibility of PBMCs from HIV-infected patients to the cytotoxic effects of hydroxylamine metabolites of sulfamethoxazole (SMX) and dapsone (DDS). Concentration-cytotoxic response data were collected using PBMCs from 12 sulfa-HS (10 SMX-HS and 2 SMX/DDS-HS) and 10 sulfa-tolerant HIV-infected individuals. Although sulfamethoxazole hydroxylamine (SMX-NOH) and dapsone hydroxylamine (DDS-NOH) both caused concentration-dependent increases in cell death, DDS-NOH was significantly more potent in each subject (P <.0001). A comparison of a variety of mean data for sulfa-HS and -tolerant patient populations failed to demonstrate the increased susceptibility of PBMCs from HS patients, noted by others, to either SMX-NOH or DDS-NOH. Moreover, any trend toward an increased susceptibility of PBMCs from HS patients was eliminated when adjusted for control cell death. PBMCs from sulfa-HS patients showed significantly greater susceptibility to the stress of short term in vitro incubation (P <. 02). Mean (S.D.) vehicle control cell death values were 24.1% (7.6%) for HS patients and 17.1% (4.4%) for tolerant patients. No significant correlation was observed between hydroxylamine-induced or control cell death and any of the recorded clinical parameters. Although several potential reasons are proposed to explain the disparity with past investigations, the data suggest that in vitro cytotoxicity is not a valid marker for HS reactions in HIV-infected individuals using currently accepted experimental procedures.  (+info)

Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation. (8/488)

Toxoplasma gondii infection reactivation predominantly occurs among patients after allogeneic haematopoietic stem cell transplantation. Mostly, reactivation occurs during first 3 months after transplant, especially when risk factors are present. We report a case of late cerebral toxoplasmosis reactivation, which was probably triggered by a brief course of corticosteroids, administered for chronic graft-versus-host disease (cGVHD). In the presence of risk factors, such as cGVHD, prophylactic treatment for toxoplasmosis should be reinstituted; Trimethoprim-sulfamethoxasole most probably prevented earlier reactivation of toxoplasmosis in our patient.  (+info)

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TrimethoprimTrimethoprim
With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken by mouth. ... Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development ... Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway. ... Edwards DL, Fink PC, van Dyke PO (1986). "Disulfiram-like reaction associated with intravenous trimethoprim-sulfamethoxazole ...
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WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
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Childhood granulomatous periorificial dermatitisChildhood granulomatous periorificial dermatitis
Trimethoprim/sulfamethoxazole has also been used. The use of oral systemic antibiotics is limited by side effects such as ...
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Trimethoprim-sulfamethoxazole (TMP/SMX) may be used in those with allergies to first-line agents or in infants who have a risk ... Antibiotics used include erythromycin, azithromycin, clarithromycin, or trimethoprim/sulfamethoxazole. Evidence to support ...
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Pneumocystis jiroveciiPneumocystis jirovecii
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https://en.wikipedia.org/wiki/Pneumocystis_jirovecii
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2005). "Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei". J Antimicrob Chemother. 55 ... 2000). "Comparison between the antimicrobial susceptibility of Burkholderia pseudomallei to trimethoprim-sulfamethoxazole by ...
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sulfamethoxazole and trimethoprim (oral/injection) | Cignasulfamethoxazole and trimethoprim (oral/injection) | Cigna
Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide. ... Sulfamethoxazole and trimethoprim is a combination antibiotic used to treat ear infections, urinary tract infections, ... Sulfamethoxazole-Trimethoprim DS. slide 5 of 13, Sulfamethoxazole-Trimethoprim DS,. 800 mg-160 mg, oval, white, imprinted with ... Sulfamethoxazole-Trimethoprim DS. slide 6 of 13, Sulfamethoxazole-Trimethoprim DS,. 800 mg-160 mg, oval, white, imprinted with ...
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Common Side Effects of Bactrim (Trimethoprim and Sulfamethoxazole) Drug Center - RxListCommon Side Effects of Bactrim (Trimethoprim and Sulfamethoxazole) Drug Center - RxList
Trimethoprim and Sulfamethoxazole) for healthcare professionals and consumers. ... Bactrim (sulfamethoxazole and trimethoprim) DS is a combination of two antibiotics used to treat urinary tract infections, ... Bactrim is available in tablets in two strengths; 400 mg sulfamethoxazole and 80 mg trimethoprim and the DS form which means ... home drugs a-z list Bactrim(Trimethoprim and Sulfamethoxazole) side effects drug center ...
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Cotrimoxazole (Sulfamethoxazole; Trimethoprim) RatiopharmCotrimoxazole (Sulfamethoxazole; Trimethoprim) Ratiopharm
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Pymeprim (Sulfamethoxazole; Trimethoprim) PymepharcoPymeprim (Sulfamethoxazole; Trimethoprim) Pymepharco
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Trimethoprim / sulfamethoxazole - St. Jude Childrens Research HospitalTrimethoprim / sulfamethoxazole - St. Jude Children's Research Hospital
Trimethoprim/sulfamethozazole (SMX-TMP, Bactrim®, or Septra® or Sulfatrim® SMX-TMP) is a medicine used to prevent or treat infections. Learn more.
https://www.stjude.org/treatment/patient-resources/caregiver-resources/medicines/a-z-list-of-medicines/trimethoprim-sulfamethoxazole.html
Treated with trimethoprim-sulfamethoxazoleAntibioticsTablets800mgFree and total sulfamethoxazole were 57.4400mgGantanolAdministered together as sulfamethoxazole andAllergicMedicationRole of trimethoprim-sulfamethoxazoleDosing of trimethoprim-sulfamethoxazoleAdministration of trimethoprim-sulfamethoxazoleInfectionsSulfonamidesRandomized trial of trimethoprimPneumocystisInteractionsInjectionGlomerular filtration and tubular secretionEffects of sulfamethoxazoleDosage for sulfamethoxazolePreparations of sulfamethoxazolePatientsDoseTabletBacterialBactrim septraOral TrimethoprimTake SulfamethoxazoleContains sulfamethoxazoleAntibiotic sulfamethoxazoleBinding of trimethoprimSulfa drugDrugsSide effectsExerts a bactericidal actionAntibacterialMean serum half-lifeDrugInfectionVitro studiesSuspensionOcular ToxoplasmosisSulfanilamidePharmacokineticsMedicinesPregnancyUrineCombinationSynthesisRatiopharmAdsorptionNorfloxacinGenericTreat
Treated with trimethoprim-sulfamethoxazole7
  • 1.Bradley PP, Warden GD, Maxwell JG, Rothstein G. Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprim-sulfamethoxazole. (webmd.com)
  • Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. (epnet.com)
  • Objectives To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone. (bmj.com)
  • Dr. Watanakunakorn requests a chart review based on our study's identification of hospitalized patients treated with trimethoprim-sulfamethoxazole and suggests the generation of a daily patient list through pharmacy records. (annals.org)
  • Eighty of 380 patients treated with trimethoprim-sulfamethoxazole were included in the study. (annals.org)
  • Patients were not treated with Trimethoprim/Sulfamethoxazole (TMP/SMX). (clinicaltrials.gov)
  • We report a woman, 78 years of age, who was treated with trimethoprim/sulfamethoxazole after a tick bite, in whom myocarditis was subsequently diagnosed. (cdc.gov)
Antibiotics10
  • Bactrim is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim . (medicinenet.com)
  • Bactrim (sulfamethoxazole and trimethoprim ) DS is a combination of two antibiotics used to treat urinary tract infections, acute otitis media , bronchitis , Shigellosis , Pneumocystis pneumonia , traveler's diarrhea , methicillin-resistant Staphylococcus aureus ( MRSA ), and other bacterial infections susceptible to this antibiotic . (rxlist.com)
  • Fish Aid Antibiotics® Sulfamethoxazole/Trimethoprim is an antibiotic that exerts a bactericidal action on gram-positive and some gram-negative bacteria in fish. (entirelypets.com)
  • The chemical moiety responsible for allergic responses is present in sulfamethoxazole and other sulfonamide antibiotics such as sulfasalazine, sulfadiazine and in anti-retrovirals amprenavir and fosamprenavir. (epmonthly.com)
  • Trimethoprim and sulfamethoxazole both belong to the class of medications called antibiotics . (medbroadcast.com)
  • Age-specific susceptibilities differed between men and women for all antibiotics studies except trimethoprim-sulfamethoxazole. (janusinfo.se)
  • Sulfamethoxazole and trimethoprim are both antibiotics that treat different types of infection caused by bacteria. (medications.com)
  • Antibiotics such as trimethoprim-sulfamethoxazole (TMP-SMX) that have reliable CNS penetration, are therefore recommended as first-line therapy. (nih.gov)
  • Are Keflex and Bactrim (sulfamethoxazole and trimethoprim) both antibiotics? (healthtap.com)
  • Bactrim ( sulfamethoxazole and trimethoprim ) is a combination sulfa antibiotic composed of two antibiotics: trimethprim and sulfamethoxazole. (healthtap.com)
Tablets16
  • Sulfamethoxazole and Trimethoprim is a synthetic antibacterial combination product available in 800 mg sulfamethoxazole and 160 mg trimethoprim Double Strength tablets and 400 mg sulfamethoxazole and 80 mg trimethoprim tablets for oral administration. (nih.gov)
  • sulfamethoxazole tablets 400mg buy anxiety covers several disorders that results in the concerned person feeling fearful or uneasy about something. (gravatar.com)
  • What are Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP)? (1800petmeds.com)
  • Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets are a combination antibiotic used to treat respiratory, urinary tract, skin, or gastrointestinal infections, and other conditions. (1800petmeds.com)
  • Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets Double Strength require a prescription from your veterinarian, and are sold per tablet. (1800petmeds.com)
  • How do Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) work? (1800petmeds.com)
  • Sulfamethoxazole and Trimethoprim Tablets are available as scored tablets. (1800petmeds.com)
  • Do not give Sulfamethoxazole and Trimethoprim Tablets to any pet other than the pet for whom it was prescribed. (1800petmeds.com)
  • Sulfamethoxazole and Trimethoprim Tablets are not for use in animals allergic to it or other sulfa drugs. (1800petmeds.com)
  • What should I discuss with my veterinarian before giving Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) to my pet? (1800petmeds.com)
  • How should Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) be given? (1800petmeds.com)
  • Give Sulfamethoxazole and Trimethoprim Tablets by mouth. (1800petmeds.com)
  • Store Sulfamethoxazole and Trimethoprim Tablets at room temperature away from moisture and heat. (1800petmeds.com)
  • Bactrim contains a combination of sulfamethoxazole and trimethoprim and is supplied in tablets and a liquid suspension. (soikin.com)
  • in tablets, each containing 400 mg sulfamethoxazole, USP and 80 mg trimethoprim, USP for oral administration. (prescriptiondrugs.com)
  • Sports Gear District West Media Kit Place an Ad Services About our Ads Portfolio Executive Team Masthead sulfamethoxazole trimethoprim tablets 160 mg sulfamethoxazole/trimethoprim drug uses sulfamethoxazole 800 mg-trimethoprim 160 mg t sulfameth trimethoprim for gonorrhea and risk of severe outcomes such as intensive care unit admission or death. (delpiano.com)
800mg3
  • Sulfamethoxazole/Trimethoprim - 800mg per day? (drugs.com)
  • Trimethoprim/sulfamethoxazole 800mg/160 is it safe for a dog to take? (drugs.com)
  • Buy Bactrim (sulfamethoxazole 800mg & trimethoprim 160mg) pills here. (jumpinjuiceandjava.com)
Free and total sulfamethoxazole were 57.41
  • The steady-state mean plasma levels for free and total sulfamethoxazole were 57.4 µg/mL and 68.0 µg/mL, respectively. (nih.gov)
400mg2
  • Oral Trimethoprim/Sulfamethoxazole 80 mg/400mg once daily for 12 weeks. (clinicaltrials.gov)
  • Bird Sulfa (Sulfamethoxazole 400mg/Trimethoprin 80mg) Control of non-specific bacterial infections in pet birds, exotic gamebirds or racing pigeons. (atozvetsupply.com)
Gantanol2
  • Sulfamethoxazole (Gantanol, Gantanol DS) is an antibiotic prescribed for the treatment of malaria, pinkeye due to chlamydia, toxoplasmosis, and urinary tract infections. (medicinenet.com)
  • Trimethoprim (Proloprim, Trimpex) is commonly combined with sulfamethoxazole (Gantanol) for an antibiotic combination that gives a one-two punch against bacteria. (epnet.com)
Administered together as sulfamethoxazole and1
  • 2 When administered together as sulfamethoxazole and trimethoprim, neither sulfamethoxazole nor trimethoprim affects the urinary excretion pattern of the other. (nih.gov)
Allergic5
  • The most common side effects of sulfamethoxazole are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). (wikipedia.org)
  • If you are allergic to sulfonamides (including sulfamethoxazole), trimethoprim, or any other medicines. (thebody.com)
  • You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, if you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid deficiency. (medications.com)
  • I'm allergic the Bactrim (sulfamethoxazole and trimethoprim), (sulfamethoxazole and trimethoprim) my fiancé was just prescribed Bactrim (sulfamethoxazole and trimethoprim) for an infection. (healthtap.com)
  • Local skin lesions are generally easily treated with Bactrim ( sulfamethoxazole and trimethoprim ) or septra , assuming you are not allergic to sulfa drugs. (healthtap.com)
Medication4
  • Sulfamethoxazole and trimethoprim may also be used for other purposes not listed in this medication guide. (medications.com)
  • To prevent any kind of negative interaction, make sure you inform your doctor of any drugs you are taking including non-prescription medication, OTCs, health supplements like vitamins, minerals, herbal medicine and so on which may interfere with the effect of Sulfamethoxazole-Trimethoprim. (internationaldrugmart.com)
  • Please describe the medication: trimethoprim sulfamethoxazole? (healthtap.com)
  • Is Bactrim (sulfamethoxazole and trimethoprim) an effective medication to treat Prostatitis? (healthtap.com)
Role of trimethoprim-sulfamethoxazole1
  • What is the role of trimethoprim-sulfamethoxazole (Bactrim) in intravenous-to-oral switch therapy? (medscape.com)
Dosing of trimethoprim-sulfamethoxazole1
  • No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of trimethoprim-sulfamethoxazole have been found. (janusinfo.se)
Administration of trimethoprim-sulfamethoxazole1
  • Among reported cases of thrombocytopenia after administration of trimethoprim-sulfamethoxazole in the Australian Adverse Drug Reactions Registry, 68% of the cases were in women [10]. (janusinfo.se)
Infections18
  • Sulfamethoxazole/trimethoprim is used for treating infections due to susceptible bacteria. (medicinenet.com)
  • Sulfamethoxazole and trimethoprim combination is used to treat intestinal or urinary tract infections. (mayoclinic.org)
  • Sulfamethoxazole and trimethoprim combination is used to treat infections such as urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). (mayoclinic.org)
  • Sulfamethoxazole/trimethoprim can also be used "off-label" to prevent and treat other opportunistic infections of HIV infection. (thebody.com)
  • What HIV-Related Opportunistic Infections Is Sulfamethoxazole/Trimethoprim Used For? (thebody.com)
  • The above list may not include all of the HIV-related uses of sulfamethoxazole/trimethoprim recommended in the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents . (thebody.com)
  • The combination of sulfamethoxazole and trimethoprim is used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, and Pneumocystis carinii pneumonia. (medications.com)
  • Oral trimethoprim/sulfamethoxazole (TMP/SMZ) therapy was investigated in the prophylaxis of infections in granulocytopenia. (nih.gov)
  • Is trimethoprim -sulfamethoxazole equivalent to vancomycin for the treatment of severe infections caused by methicillin-resistant Staphyloccus aureus? (the-hospitalist.org)
  • Trimethoprim -sulfamethoxazole (TMP-SMX) did not achieve noninferiority as compared with vancomycin for the treatment of severe methicillin-resistant Staphyloccus aureus (MRSA) infections in hospitalized patients, and it may lead to increased mortality in the subset of patients with bacteremia. (the-hospitalist.org)
  • Thomas Labs Bird Sulfa (Sulfamethoxazole Trimethoprim, SMZ-TMP) is for antibiotic given for systemic and local non-specific bacterial infections in pet birds, exotic birds and pigeons. (medi-vet.com)
  • Sulfamethoxazole-Trimethoprim is a combination drug that is very effective in treating a wide range of bacterial infections such as ear infections, urinary tract infections, traveler's diarrhea, respiratory infections, bronchitis and pneumocystis carinii pneumonia. (internationaldrugmart.com)
  • Trimethoprim-sulfamethoxazole (TMP-SMX) 480 mg once daily is more effective than cranberry capsules 500 mg twice daily for the prevention of recurrent urinary tract infections (UTIs) in premenopausal women-but it exacerbates the problem of emerging antibiotic resistance. (contemporaryobgyn.net)
  • Trimethoprim sulfamethoxazole ( septra (sulfamethoxazole and trimethoprim) or bactrim ) is an antibiotic used for urinary, respiratory and middle ear infections. (healthtap.com)
  • In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. (nih.gov)
  • Bactrim (sulfamethoxazole and trimethoprim) (also called Septra or Trimethoprim-Sulfamethoxazole) is an antibiotic for treating bacterial infections . (healthtap.com)
  • Oral trimethoprim/sulfamethoxazole (TMP-SMX) is approved by the US Food and Drug Administration for the treatment of urinary tract infections, shigellosis, acute otitis media in pediatric patients, and Pneumocystis carinii pneumonia. (mdedge.com)
  • Sulfamethoxazole is a broad-spectrum antibiotic with particularly strong efficacy on Staphylococcus aureus and Escherichia coli and can be used for the treatment of urinary tract infections and fowl cholera. (chemicalbook.com)
Sulfonamides3
  • Sulfonamides such as sulfamethoxazole can increase the metabolism (break-down and elimination) of cyclosporine (causing loss of effectiveness of cyclosporine), and can add to the kidney damage caused by cyclosporine. (medicinenet.com)
  • Sulfamethoxazole is contraindicated in people with a known hypersensitivity to trimethoprim or sulfonamides. (wikipedia.org)
  • Sulfamethoxazole/trimethoprim should not be used by pregnant women because sulfonamides (including sulfamethoxazole) may cause kernicterus. (thebody.com)
Randomized trial of trimethoprim1
  • Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis. (nih.gov)
Pneumocystis2
  • Evaluation the efficacy and safety profile of trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia (PCP) prophylaxis in Patients With Connective Tissue Diseases (CTD) treated with high-dose glucocorticoids and immunosuppressive agents. (clinicaltrials.gov)
  • With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. (wikipedia.org)
Interactions2
  • Ask your health care provider if there are interactions between sulfamethoxazole/trimethoprim and the other medicines you take. (thebody.com)
  • Drug interactions might happen either when Sulfamethoxazole-Trimethoprim is taken along with another drug or with particular foods. (internationaldrugmart.com)
Injection1
  • sulfamethoxazole and trimethoprim (oral/injection) (Bactrim, Bactrim DS, Bactrim I.V. (emedicinehealth.com)
Glomerular filtration and tubular secretion2
  • Excretion Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion. (wikipedia.org)
  • Excretion of sulfamethoxazole and trimethoprim is primarily by the kidneys through both glomerular filtration and tubular secretion. (nih.gov)
Effects of sulfamethoxazole2
Dosage for sulfamethoxazole2
Preparations of sulfamethoxazole2
  • What preparations of sulfamethoxazole and trimethoprim are available? (medicinenet.com)
  • What preparations of sulfamethoxazole are available? (medicinenet.com)
Patients13
  • Patients receiving sulfamethoxazole should avoid excessive exposure to sunlight and should wear sunscreen . (medicinenet.com)
  • However, elderly patients are more likely to have age-related kidney or liver problems, which may require an adjustment in the dose for patients receiving sulfamethoxazole and trimethoprim combination. (mayoclinic.org)
  • The population attributable fraction was 59.7%, suggesting that approximately 60% of all cases of hyperkalaemia in older patients taking spironolactone and treated with an antibiotic for a urinary tract infection could be avoided if trimethoprim-sulfamethoxazole was not prescribed. (bmj.com)
  • Conclusions Among older patients receiving spironolactone, treatment with trimethoprim-sulfamethoxazole was associated with a major increase in the risk of admission to hospital for hyperkalaemia. (bmj.com)
  • Similarly, a study of adverse reactions among hospitalized medical patients (292 men, 357 women) receiving trimethoprim-sulfamethoxazole 80/400 mg showed that reactions were reported more often in women. (janusinfo.se)
  • such pneumonia occurred in 53% of patients receiving placebo and developed within 5 months in 80% of patients who sulfamethoxazole tr co-trimoxazole because of toxicity. (soxanddawgs.com)
  • Sulfamethoxazole et trimethoprime Co-trimoxazole is used for prophylaxis of PCP in patients with HIV infection, although an increased risk of toxicity in these patients has been reported. (soxanddawgs.com)
  • In addition, patients receiving the drug for prophylaxis of PCP appear to tolerate the drug better sulfamethoxazole et trimethoprime those sulfamethoxazole et trimethoprime receiving it for treatment of PCP. (soxanddawgs.com)
  • such pneumonia occurred in 53% of patients receiving placebo and developed within 5 months sulfamethoxazole et trimethoprime 80% of patients who discontinued co-trimoxazole because of toxicity and para que es sulfamethoxazole buy real online prescription drugs . (soxanddawgs.com)
  • Patients received Trimethoprim/Sulfamethoxazole (TMP/SMX) 80 mg/400 mg p.o. every day as PCP Prophylaxis. (clinicaltrials.gov)
  • Using concealed allocation, the investigators randomized the patients to receive either high-dose TMP-SMX (320 mg trimethoprim /1600 mg sulfamethoxazole intravenously twice daily) or vancomycin (1 mg intravenously twice daily) for at least 7 days. (the-hospitalist.org)
  • Fifty-nine patients with active ocular toxoplasmosis were randomly assigned to 2 treatment groups: 29 were treated with pyrimethamine/sulfadiazine, and 30 patients received trimethoprim/sulfamethoxazole. (nih.gov)
  • Active toxoplasmosis retinochoroiditis resolved in all patients over 6 weeks' treatment, with no significant difference in mean reduction of retinochoroidal lesion size between the 2 treatment groups (61% reduction in the classic treatment group and 59% in the trimethoprim/sulfamethoxazole group, P = 0.75). (nih.gov)
Dose4
  • The average percentage of the dose recovered in urine from 0 to 72 hours after a single oral dose of sulfamethoxazole and trimethoprim is 84.5% for total sulfonamide and 66.8% for free trimethoprim. (nih.gov)
  • The objective of this study was to investigate risk factors for cytopenia when a prophylactic dose of trimethoprim-sulfamethoxazole (TMP-SMX) was co-administered with methotrexate (MTX). (springer.com)
  • The administrated dose trimethoprim-sulfamethoxazole was unspecified [9]. (janusinfo.se)
  • were randomly assigned to three treatment groups: 1) norfloxacin in a single 800-mg dose, 2) norfloxacin, 400 mg twice a day for three days, and 3) trimethoprim (160 mg)-sulfamethoxazole (800 mg) (TMP-SMX), twice a day for three days. (ajtmh.org)
Tablet6
  • Each Double Strength tablet contains 800 mg sulfamethoxazole and 160 mg trimethoprim plus magnesium stearate, pregelatinized starch and sodium starch glycolate. (nih.gov)
  • Each tablet contains 400 mg sulfamethoxazole and 80 mg trimethoprim plus magnesium stearate, pregelatinized starch, and sodium starch glycolate. (nih.gov)
  • Does Azo-Sulfamethoxazole Tablet interact with other drugs you are taking? (webmd.com)
  • Are you currently using Azo-Sulfamethoxazole Tablet? (webmd.com)
  • Each white, round, scored tablet, marked with 'N' over '80', contains sulfamethoxazole 400 mg and trimethoprim 80 mg. (medbroadcast.com)
  • SMZ Sulfa Trimethoprim Tablet is a sulfonamide antibiotic combination of trimethoprim and sulfamethoxazole. (allivet.com)
Bacterial4
  • Sulfamethoxazole is an anti-bacterial sulfonamide, a 'sulfa' drug. (medicinenet.com)
  • Since it inhibits bacterial growth, sulfamethoxazole is considered a bacteriostatic antibiotic. (wikipedia.org)
  • Sulfamethoxazole and trimethoprim are both competitive antagonists of bacterial enzymes in the folic acid synthesis pathway. (epmonthly.com)
  • Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). (thefreedictionary.com)
Bactrim septra2
  • Lei L, Li Z, Zhong G. Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein trimethoprim sulfamethoxazole bactrim septra others PRAK PLoS One. (soxanddawgs.com)
  • In vitro studies https://soxanddawgs.com/trimethoprim-sulfamethoxazole-bactrim-septra-others-1977729/out-of-date-trimethoprim sulfamethoxazole is not a substrate of the P-glycoprotein transporter. (soxanddawgs.com)
Oral Trimethoprim1
  • The children were safely discharged home on a 7-day course of oral trimethoprim-sulfamethoxazole and metronidazole when enteral intake was tolerated, regardless of fever or leukocytosis. (medscape.com)
Take Sulfamethoxazole3
  • How Should I Take Sulfamethoxazole/Trimethoprim? (thebody.com)
  • Take sulfamethoxazole/trimethoprim according to your health care provider's instructions. (thebody.com)
  • You should not take sulfamethoxazole and trimethoprim if you are pregnant or breastfeeding. (cigna.com)
Contains sulfamethoxazole1
  • Each 5 mL of light pink-coloured liquid suspension contains sulfamethoxazole 200 mg and trimethoprim 40 mg. (medbroadcast.com)
Antibiotic sulfamethoxazole1
  • Bactrim is the brand name of the generic antibiotic sulfamethoxazole trimethoprim (sometimes called co-trimoxazole). (everydayhealth.com)
Binding of trimethoprim1
  • The presence of 10 percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree, trimethoprim does not influence the protein binding of sulfamethoxazole. (nih.gov)
Sulfa drug1
Drugs2
  • Which drugs or supplements interact with sulfamethoxazole and trimethoprim? (medicinenet.com)
  • We report the case of a patient with early Wegener granulomatosis confined to the nasal mucosa treated successfully with trimethoprim-sulfamethoxazole without previous immunosuppresant drugs. (annals.org)
Side effects2
  • Ask your health care provider about possible side effects from sulfamethoxazole/trimethoprim. (thebody.com)
  • Uti septra (sulfamethoxazole and trimethoprim) ds side effects? (healthtap.com)
Exerts a bactericidal action1
  • Thomas Labs Fish Sulfa Forte (Sulfamethoxazole/Trimethoprim - SMZ-TMP) exerts a bactericidal action on gram-negative bacteria. (medi-vet.com)
Antibacterial2
  • A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). (drugs.com)
  • Poe M (1976) Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole. (springer.com)
Mean serum half-life2
  • The mean serum half-life of sulfamethoxazole is 10 hours. (wikipedia.org)
  • The mean serum half-life (t1/2) of Sulfamethoxazole evaluated after oral co-administration of Sulfamethoxazole and Trimethoprim. (nih.gov)
Drug11
  • Is sulfamethoxazole and trimethoprim available as a generic drug? (medicinenet.com)
  • About 20% of the sulfamethoxazole in urine is the unchanged drug, about 15-20% is the N-glucuronide conjugate, and about 50-70 % is the acetylated metabolite. (wikipedia.org)
  • Detectable amounts of sulfamethoxazole and trimethoprim are present in the blood 24 hours after drug administration. (nih.gov)
  • sulfamethoxazole is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/109135/1/sulfamethoxazole. (unboundmedicine.com)
  • It's one part trimethoprim (a synthetic drug), and five parts sulfamethoxazole (a sulfonamide drug). (everydayhealth.com)
  • Drug classes analyzed was ampicillin, nitrofurantoin, fluoroquinolones (ciprofloxacin and levofloxacin), trimethoprim-sulfamethoxazole, gentamicin, and ceftriazone/cefotaxime, Women exhibited higher susceptibility values for all drug classes studied than men. (janusinfo.se)
  • Generic drug Sulfamethoxazole-Trimethoprim is considered just as safe and effective as its brand-name equivalents such as Bactrim and Cotribene. (internationaldrugmart.com)
  • Did you know that buying the generic drug Sulfamethoxazole-Trimethoprim from IDM is much cheaper than buying the Bactrim or Cotribene brand drug? (internationaldrugmart.com)
  • Drug efficacies in terms of reduction in retinal lesion size and improvement in VA were similar in a regimen of trimethoprim/sulfamethoxazole and the classic treatment of ocular toxoplasmosis with pyrimethamine and sulfadiazine. (nih.gov)
  • Sulfamethoxazole belongs to a systemic, moderate sulfonamide drug. (chemicalbook.com)
Infection7
  • Sulfamethoxazole/Trimethoprim - Strong Enough For Kidney Infection? (drugs.com)
  • A randomized controlled study has evaluated the effect of recommended gonorrhea-treatment regimens on simultaneous chlamydial infection (46 men and 44 women on trimethoprim-sulfamethoxazole). (janusinfo.se)
  • Sulfamethoxazole and trimethoprim will not treat a viral infection such as the common cold or flu. (medications.com)
  • Trimethoprim-sulfamethoxazole 480 mg once daily is more effective than cranberry capsules 500 mg twice daily for the prevention of recurrent urinary tract infection in premenopausal women, but it exacerbates the problem of emerging antibiotic resistance. (contemporaryobgyn.net)
  • Can cotrim (trimethoprim sulfamethoxazole) forte ratiopharm treat a urinary tract infection? (healthtap.com)
  • If you are tempted to use Bactrim (sulfamethoxazole and trimethoprim) left over from some other infection becuase you suspect you have gonorrhea or were exposed. (healthtap.com)
  • Upon diagnosis of ADPKD with cyst infection, antibiotic therapy was switched from cefotaxime to trimethoprim/sulfamethoxazole to achieve better cyst penetration, which successfully resolved the infection. (frontiersin.org)
Vitro studies1
  • In vitro studies suggest sulfamethoxazole is not a substrate of the P-glycoprotein transporter. (wikipedia.org)
Suspension3
  • anhydrous glycerin, microcrystalline cellulose, polysorbate 80, purified suspension contains trimethoprim and sulphamethoxazole following additional inactive ingredients: FD and C Red No. 40, FD and C Blue No. 1 and natural and artificial grape flavor. (soxanddawgs.com)
  • One of the dosage forms available for Trimethoprim/Sulfamethoxazole is Oral Oil Suspension. (wedgewoodpharmacy.com)
  • 12 strength combinations of Trimethoprim/Sulfamethoxazole Oral Oil Suspension are available. (wedgewoodpharmacy.com)
Ocular Toxoplasmosis2
  • To compare the efficacy of the classic treatment of ocular toxoplasmosis (pyrimethamine, sulfadiazine, and prednisolone) with a regimen consisting of trimethoprim/sulfamethoxazole (co-trimoxazole) plus prednisolone. (nih.gov)
  • Therapy with trimethoprim/sulfamethoxazole seems to be an acceptable alternative for the treatment of ocular toxoplasmosis. (nih.gov)
Sulfanilamide2
  • Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). (wikipedia.org)
  • 40, FD and C Yellow No. 6 and artificial cherry Sulfamethoxazole is N1 5-methyl-3-isoxazolyl sulfanilamide. (soxanddawgs.com)
Pharmacokinetics2
  • Also to determine whether the pharmacokinetics of AZT is changed when trimethoprim/sulfamethoxazole (SMX/TMP) is given at the same time, or whether the pharmacokinetics of SMX/TMP is altered by AZT given at the same time. (clinicaltrials.gov)
  • Geriatric Pharmacokinetics: The pharmacokinetics of sulfamethoxazole 800 mg and trimethoprim 160 mg were studied in 6 geriatric subjects (mean age: 78.6 years) and 6 young healthy subjects (mean age: 29.3 years) using a non-US approved formulation. (prescriptiondrugs.com)
Medicines2
  • Sulfamethoxazole/trimethoprim may affect the way other medicines or products work, and other medicines or products may affect how sulfamethoxazole/trimethoprim works. (thebody.com)
  • The medicines below all contain the following active ingredient(s): trimethoprim + sulfamethoxazole. (healthdirect.gov.au)
Pregnancy3
  • For this reason, sulfamethoxazole/trimethoprim should not be used near term (late in pregnancy ) among women. (medicinenet.com)
  • SULFAMETHOXAZOLE & TRIMETHOPRIM Avoid using sulfamethoxazole / trimethoprim during the last 6 weeks of pregnancy. (soxanddawgs.com)
  • Sulfamethoxazole: Sulfamethoxazole lower abdomen pain, pregnancy hormone, bla. (medications.com)
Urine3
  • Sulfamethoxazole/trimethoprim should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. (medicinenet.com)
  • Sulfamethoxazole may form crystals in the urine which may damage the kidney and cause bleeding into the urine. (medicinenet.com)
  • Urine concentrations of both sulfamethoxazole and trimethoprim are considerably higher than the concentrations in the blood. (nih.gov)
Combination5
  • Sulfamethoxazole is now used primarily in combination with trimethoprim , a combination product known as Bactrim or Septra . (medicinenet.com)
  • Sulfamethoxazole and trimethoprim combination is an antibiotic. (mayoclinic.org)
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in children older than 2 months of age. (mayoclinic.org)
  • It may be involved in a reaction similar to disulfiram when alcohol is consumed after it is used, in particular when used in combination with sulfamethoxazole. (wikipedia.org)
  • Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance. (wikipedia.org)
Synthesis1
  • Sulfamethoxazole is an intermediate-acting sulfonamide which interferes with the synthesis of nucleic acids in sensitive organisms by blocking the conversion of PABA to the coenzyme dihydrofolic acid. (mims.com)
Ratiopharm1
  • Use cotrim (trimethoprim sulfamethoxazole) forte ratiopharm against uti? (healthtap.com)
Adsorption1
  • From day 46 to 160, significant adsorption of sulfamethoxazole and carbamazepine to PAC was confirmed by a series of adsorption tests (adsorption contributed around 40% to the overall removal). (edu.au)
Norfloxacin1
  • Participants Cases were residents of Ontario aged 66 years or above receiving chronic treatment with spironolactone and admitted to hospital with hyperkalaemia within 14 days of receiving a prescription for either trimethoprim-sulfamethoxazole, amoxicillin, norfloxacin, or nitrofurantoin. (bmj.com)
Generic2
  • According to the FDA database, all brand and generic formulations of sulfamethoxazole have been discontinued. (medicinenet.com)
  • anyone buy bactrim online no prescription is it safe to buy sulfamethoxazole online yahoo genuine sulfamethoxazole cheapest sulfamethoxazole bars order order sulfamethoxazole online buy where to purchase sulfamethoxazole australia how buy sulfamethoxazole ie sulfamethoxazole generic buy line buying generic bactrim work yahoo buy real sulfamethoxazole online legally buy sulfamethoxazole for women online forum so that kidney failure is not the only outcome. (gravatar.com)
Treat3
Sulfamethoxazole | C10H11N3O3S - PubChem
Sulfamethoxazole | C10H11N3O3S - PubChem (pubchem.ncbi.nlm.nih.gov)
Sulfamethoxazole and Trimethoprim Tablets vs. Cephalexin Comparison | 1-800-PetMeds®
Sulfamethoxazole and Trimethoprim Tablets vs. Cephalexin Comparison | 1-800-PetMeds® (1800petmeds.com)
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CellCept (Mycophenolate Mofetil): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
On the Nature of Hydrodynamic Cavitation Process and Its Application for the Removal of Water Pollutants
On the Nature of Hydrodynamic Cavitation Process and Its Application for the Removal of Water Pollutants (bioone.org)
BACTRIM (sulfamethoxazole and trimethoprim tablet) | Healthgrades
BACTRIM (sulfamethoxazole and trimethoprim tablet) | Healthgrades (drugs.healthgrades.com)
Buy primaquine online, Primaquine versus trimethoprim-sulfamethoxazole
Buy primaquine online, Primaquine versus trimethoprim-sulfamethoxazole (nmch.org.uk)
Sulfamethoxazole (Gantanol, Urobak) | Davis's Drug Guide
Sulfamethoxazole (Gantanol, Urobak) | Davis's Drug Guide (unboundmedicine.com)
List of drugs/medicine used for Cystic Fibrosis (Fibrocystic Disease)
List of drugs/medicine used for Cystic Fibrosis (Fibrocystic Disease) (medindia.net)
Sulfamethoxazole/Trimethoprim (Oral Route) Description and Brand Names - Mayo Clinic
Sulfamethoxazole/Trimethoprim (Oral Route) Description and Brand Names - Mayo Clinic (mayoclinic.org)
Sulphamethoxazole+Trimethoprim | Cure Bacterial Infections
Sulphamethoxazole+Trimethoprim | Cure Bacterial Infections (cheapmedicineshop.com)
Antibiotics for Staph Strep Infections | LIVESTRONG.COM
Antibiotics for Staph Strep Infections | LIVESTRONG.COM (livestrong.com)
DailyMed - MYCOPHENOLATE MOFETIL- mycophenolate mofetil capsule
DailyMed - MYCOPHENOLATE MOFETIL- mycophenolate mofetil capsule (dailymed.nlm.nih.gov)
Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline | The BMJ
Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline | The BMJ (bmj.com)
Which medications in the drug class Antibiotics are used in the treatment of Colitis?
Which medications in the drug class Antibiotics are used in the treatment of Colitis? (medscape.com)
Gram-Negative Folliculitis Medication: Retinoid-like Agents, Antibiotics, Other, Acne Agents, Topical
Gram-Negative Folliculitis Medication: Retinoid-like Agents, Antibiotics, Other, Acne Agents, Topical (emedicine.medscape.com)
Tren ace cough | sulfamethoxazole-trimethoprim oral (Bactrim DS Oral.
Tren ace cough | sulfamethoxazole-trimethoprim oral (Bactrim DS Oral. (bcg.stoynev.us)
Which medications in the drug class Antibiotics are used in the treatment of Animal Bites in Emergency Medicine?
Which medications in the drug class Antibiotics are used in the treatment of Animal Bites in Emergency Medicine? (medscape.com)
Khapzory (Levoleucovorin Injection): Uses, Dosage, Side Effects, Interactions, Warning
Khapzory (Levoleucovorin Injection): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
Cat Scratch Disease (Cat Scratch Fever) Medication: Antibiotics
Cat Scratch Disease (Cat Scratch Fever) Medication: Antibiotics (emedicine.medscape.com)
Hyperkalemia and Trimethoprim-Sulfamethoxazole | Annals of Internal Medicine | American College of Physicians
Hyperkalemia and Trimethoprim-Sulfamethoxazole | Annals of Internal Medicine | American College of Physicians (annals.org)
Cures for Staph Infections | LIVESTRONG.COM
Cures for Staph Infections | LIVESTRONG.COM (livestrong.com)
Trimethoprim / sulfamethoxazole - St. Jude Children's Research Hospital
Trimethoprim / sulfamethoxazole - St. Jude Children's Research Hospital (stjude.org)
Cholera Medication: Antibiotics, Vaccines
Cholera Medication: Antibiotics, Vaccines (emedicine.medscape.com)
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Legionella Infection Medication: Antibiotics (emedicine.medscape.com)
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Granulomatosis with Polyangiitis (GPA, formerly Wegener Granulomatosis) Medication: Corticosteroids, Antineoplastics,... (emedicine.medscape.com)
Prostatitis Medication: Antibiotics, Alpha-adrenergic antagonists
Prostatitis Medication: Antibiotics, Alpha-adrenergic antagonists (emedicine.medscape.com)