Sufentanil
Fentanyl
Analgesia, Obstetrical
Analgesics, Opioid
Analgesia, Epidural
Alfentanil
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Anesthetics, Intravenous
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Injections, Spinal
Anesthetics
Anesthesia, Intravenous
Anesthetics, Combined
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Labor, Obstetric
Preanesthetic Medication
Adjuvants, Anesthesia
Labor Stage, First
Double-Blind Method
Anesthesia, Obstetrical
Analgesia, Patient-Controlled
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
Subarachnoid Space
Amides
Pruritus
Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. (1/224)
BACKGROUND: Sufentanil is a potent but short-acting spinal analgesic used to manage perioperative pain. This study evaluated the influence of transdermal nitroglycerine on the analgesic action of spinal sufentanil in patients undergoing orthopedic surgery. METHODS: Fifty-six patients were randomized to one of four groups. Patients were premedicated with 0.05-0.1 mg/kg intravenous midazolam and received 15 mg bupivacaine plus 2 ml of the test drug intrathecally (saline or 10 microg sufentanil). Twenty to 30 min after the spinal puncture, a transdermal patch of either 5 mg nitroglycerin or placebo was applied. The control group received spinal saline and transdermal placebo. The sufentanil group received spinal sufentanil and transdermal placebo. The nitroglycerin group received spinal saline and transdermal nitroglycerine patch. Finally, the sufentanil-nitroglycerin group received spinal sufentanil and transdermal nitroglycerine. Pain and adverse effects were evaluated using a 10-cm visual analog scale. RESULTS: The time to first rescue analgesic medication was longer for the sufentanil-nitroglycerin group (785+/-483 min) compared with the other groups (P<0.005). The time to first rescue analgesics was also longer for the sufentanil group compared with the control group (P<0.05). The sufentanil-nitroglycerin group group required less rescue analgesics in 24 h compared with the other groups (P<0.02) and had lesser 24-h pain visual analog scale scores compared with the control group (P<0.005), although these scores were similar to the sufentanil and nitroglycerin groups (P>0.05). The incidence of perioperative adverse effects was similar among groups (P>0.05). CONCLUSIONS: Transdermal nitroglycerine alone (5 mg/day), a nitric oxide generator, did not result in postoperative analgesia itself, but it prolonged the analgesic effect of spinal sufentanil (10 microg) and provided 13 h of effective postoperative analgesia after knee surgery. (+info)A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. (2/224)
BACKGROUND: This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. METHODS: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 ml bupivacaine, 0.125%, plus 7.5 microg sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 microg sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. RESULTS: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/-15 min and lasted +/-90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P<0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. CONCLUSIONS: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade. (+info)Effects of propofol, propofol-nitrous oxide and midazolam on cortical somatosensory evoked potentials during sufentanil anaesthesia for major spinal surgery. (3/224)
Recording of cortical somatosensory evoked potentials (CSEP) enables monitoring of spinal cord function. We studied the effects of propofol, propofol-nitrous oxide or midazolam during sufentanil anaesthesia on CSEP monitoring during major spinal surgery. Thirty patients with normal preoperative CSEP were allocated randomly to one of the following anaesthesia regimens: propofol (2.5 mg kg-1 followed by 10-6 mg kg-1 h-1) with or without nitrous oxide, or midazolam (0.3 mg kg-1 followed by 0.15 mg kg-1 h-1) combined with sufentanil 0.5 microgram kg-1 h-1 in the propofol and midazolam groups, or 0.25 microgram kg-1 h-1 in the propofol-nitrous oxide group. CSEP were elicited by alternate right and left tibial posterior nerve stimulation and recorded before and after induction (15 min, 1, 2 and 3 h), and during skin closure. CSEP latencies were not significantly modified in the three groups. CSEP amplitude decreased significantly in the propofol-nitrous oxide group (from mean 2.0 (SEM 0.3) to 0.6 (0.1) microV; P < 0.05) but not in the propofol (from 1.8 (0.6) to 2.2 (0.3) microV) or midazolam (1.7 (0.5) to 1.6 (0.5) microV) groups. The time to the first postoperative voluntary motor response (recovery) delay was significantly greater in the midazolam group (115 (19) min) compared with the propofol and propofol-nitrous oxide groups (43 (8) and 41 (3) min, respectively). Consequently, the use of propofol without nitrous oxide can be recommended during spinal surgery when CSEP monitoring is required. (+info)Intrathecal neostigmine and sufentanil for early labor analgesia. (4/224)
BACKGROUND: Recent efforts to improve the combined spinal epidural (CSE) technique have focused on adding opioids to other classes of analgesics. In this study, the authors used intrathecal neostigmine in combination with intrathecal sufentanil to investigate the usefulness of neostigmine for reducing side effects and prolonging the duration of sufentanil. METHODS: One hundred six healthy pregnant women in labor were enrolled in this study, which was divided into four phases. In all phases, patients received a CSE anesthetic while in the lateral position. In phase I, three groups of six women each received intrathecal neostigmine, 5, 10, or 20 microg, in an open-label, dose-escalating safety assessment. In phase II, 24 women received intrathecal sufentanil alone to establish an ED50 (dose that produces > 60 min of labor analgesia in 50% of patients). In phase III, an ED50 was established for sufentanil combined with a fixed dose of neostigmine (10 microg). In phase IV, 40 women received either twice the ED50 of sufentanil alone or twice the ED50 of sufentanil plus neostigmine, 10 microg. RESULTS: Neostigmine alone had no adverse effects on maternal vital signs, fetal heart rate, or Apgar scores. Neostigmine, 20 microg, produced analgesia in one patient and severe nausea and vomiting in another. The ED50 for intrathecal sufentanil alone was 4.1 +/- 0.31 microg, and the ED50 for intrathecal sufentanil combined with neostigmine, 10 microg, was 3.0 +/- 0.28 microg. The duration of analgesia and side effects from double these ED50s (sufentanil, 9 microg, or sufentanil, 6 microg, plus neostigmine, 10 microg) were similar between groups. CONCLUSIONS: The 10-microg intrathecal neostigmine dose alone produced no analgesia or side effects, but reduced the ED50 of intrathecal sufentanil by approximately 25%. Additionally, doses approximately double these ED50s each produced a similar duration of analgesia and side effects, indicating intrathecal neostigmine shifts the dose-response curve for intrathecal sufentanil to the left. (+info)Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients. (5/224)
BACKGROUND: The relative potencies of alfentanil, fentanyl, and sufentanil as a risk factor for postoperative nausea and vomiting have not been determined. They were compared in a randomized study designed to obtain equipotent plasma concentrations of these three opioids at the beginning of the recovery period. METHODS: The study included 274 patients treated on an outpatient basis. The steady state opioid plasma concentration providing a predicted 50% reduction of the minimum alveolar concentration of isoflurane was used to determine the relative potency of the opioids. The opioids were prepared in equal volumes at concentrations of alfentanil 150 microg/ml, fentanyl 50 microg/ml, and sufentanil 5 microg/ml and were administered in vol/kg. Anesthesia was induced in a blinded fashion with a bolus of the study opioid (0.05 ml/kg) and 4-6 mg/kg thiopental and was maintained with isoflurane (0.6-1%) in a nitrous oxide-oxygen mixture with a continuous infusion of the study opioid (0.06 ml x kg(-1) x h(-1)). If necessary, up to five additional boluses of opioid (0.02 ml/kg) could be given. This opioid administration protocol was tested by pharmacokinetic simulations. RESULTS: The incidence of postoperative nausea and vomiting was not different in the postanesthesia care unit, but in the ambulatory surgery unit it was significantly lower for alfentanil compared with fentanyl and sufentanil (12, 34, and 35%, respectively P < 0.005). Pharmacokinetic modeling showed that the end-anesthesia opioid plasma concentrations were approximately equipotent in the three groups. However, modeling does not support that the difference between groups in the postoperative period can be explained by a more rapid disappearance of alfentanil from the plasma. CONCLUSIONS: Alfentanil, compared with approximately equipotent doses of fentanyl and sufentanil, is associated with a lower incidence of postoperative nausea and vomiting in outpatients. (+info)Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. (6/224)
BACKGROUND: Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to characterize the rate and extent of opioid distribution within cerebrospinal fluid, spinal cord, epidural space, and systemic circulation after intrathecal injection. METHODS: Equal doses of morphine and alfentanil, fentanyl, or sufentanil were administered intrathecally (L3) to anesthetized pigs. Microdialysis probes were used to sample cerebrospinal fluid at L2, T11, T7, T3, and the epidural space at L2 every 5-10 min for 4 h. At the end of the experiment, spinal cord and epidural fat tissue were sampled, and each probe's recovery was determined in vitro. Using SAAM II pharmacokinetic modeling software (SAAM Institute, University of Washington, Seattle, WA), the data were fit to a 16-compartment model that was divided into four spinal levels, each of which consisted of a caternary arrangement of four compartments representing the spinal cord, cerebrospinal fluid, epidural space, and epidural fat. RESULTS: Model simulations revealed that the integral exposure (area under the curve divided by dose) of the spinal cord (i.e., effect compartment) to the opioids was highest for morphine because of its low spinal cord distribution volume and slow clearance into plasma The integral exposure of the spinal cord to the other opioids was relatively low, but for different reasons: alfentanil has a high clearance from spinal cord into plasma, fentanyl distributes rapidly into the epidural space and fat, and sufentanil has a high spinal cord volume of distribution. CONCLUSIONS: The four opioids studied demonstrate markedly different pharmacokinetic behavior, which correlates well with their pharmacodynamic behavior. (+info)Involvement of the cyclic AMP system in the switch from tolerance into supersensitivity to the antinociceptive effect of the opioid sufentanil. (7/224)
1. We have previously demonstrated that chronic and simultaneous treatment of rats with the mu-opioid receptor agonist sufentanil and the Ca(2+) channel blocker nimodipine, not only prevented tolerance development, but the animals became supersensitive to the antinociceptive effect of the opioid. The focus of the present work was to determine the possible involvement of cross interactions between the adenylyl cyclase pathway and L-type voltage-sensitive Ca(2+)-channels, in modulating the switch from opioid tolerance into supersensitivity. 2. The modulatory effect of sufentanil on adenylyl cyclase activity was determined by measuring cyclic AMP production in slices from the cortex of rats rendered tolerant or supersensitive to the antinociceptive effect of the opioid. Tolerance was induced by chronic infusion of sufentanil, at a rate of 2 microg h(-1), for 7 days. Supersensitivity was induced by concurrent infusion of sufentanil (2 microg h(-1)) and nimodipine (1 microg h(-1)) for 7 days. Antinociception was evaluated by the tail-flick test. 3. Tolerance to the analgesic effect of sufentanil was associated with a significant reduction in the response of adenylyl cyclase to forskolin. Furthermore, the effect of the opioid on forskolin-induced cyclic AMP accumulation was abolished. On the other hand, supersensitivity to the analgesic effect of the opioid was associated with an increase in both, the adenylyl cyclase response to forskolin, and the opioid inhibition of cyclic AMP production. 4. We suggest that sustained L-type Ca(2+) channel blockade may result in changes in the adenylyl cyclase effector system triggered by mu-opioid receptor activation, leading to the switch from opioid tolerance into supersensitivity. (+info)The dose-response of intrathecal sufentanil added to bupivacaine for labor analgesia. (8/224)
BACKGROUND: Regional analgesia for labor often is initiated with an intrathecal injection of a local anesthetic and opioid. The purpose of this prospective, randomized, blinded study was to determine the optimal dose of intrathecal sufentanil when combined with 2.5 mg bupivacaine for labor analgesia. METHODS: One hundred seventy parous parturients with cervical dilation between 3-5 cm were randomized to receive intrathecal 0 (control), 2.5, 5.0, 7.5, or 10.0 microg sufentanil combined with 2.5 mg bupivacaine, followed by a lidocaine epidural test dose, for initiation of analgesia (34 patients in each group). Visual analog scores and the presence of nausea, vomiting, and pruritus were determined every 15 min until the patient requested additional analgesia. Fetal heart rate tracings were compared between groups. RESULTS: Groups were similar for age, height, weight, oxytocin dose, duration of labor, and baseline visual analog scores. Duration of action was significantly shorter for control patients (39 +/- 25 min [mean +/- SD]) compared with those administered sufentanil, all doses (93 +/- 32, 93 +/- 47, 94 +/- 33, 97 +/- 39 min), but was not different among groups administered 2.5, 5.0, 7.5, or 10.0 microg sufentanil. More patients who received 10 microg sufentanil reported nausea and vomiting than did control patients. The severity of pruritus increased with administration of 7.5 and 10.0 microg sufentanil. There was no difference in fetal heart rate changes among groups. CONCLUSIONS: Intrathecal bupivacaine (2.5 mg) without sufentanil did not provide satisfactory analgesia for parous patients. However, bupivacaine combined with 2.5 microg sufentanil provided analgesia comparable to higher doses, with a lower incidence of nausea and vomiting and less severe pruritus. (+info)Sufentanil infusion before extubation suppresses coughing on emergence without delaying extubation time and reduces...
Sufentanil - Wikipedia
Remifentanil versus Sufentanil em infusão contínua em intervenções cirúrgicas videolaparoscópicas: estudo comparativo
Sufentanil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Global and Chinese Sufentanil Industry (CAS 56030-54-7) 2019 Analysis of Key Manufacturer and Forecasts: RnR Market Research
HEMODYNAMIC EFFECTS OP BW A938U IN CORONARY ARTERY BYPASS GRAFT AND VALVE REPLACEMENT PATIENTS RECEIVING OXYGEN SUFENTANIL...
European Medicines Agency Begins Evaluation of Marketing Application for Sublingual Sufentanil 30 mcg Tablet (ARX-04) for...
Effect of intrathecal sufentanil on hemodynamic change in spinal anesthesia with lidocain 5% for cesarean section - Journal of...
Sufentanil Test | Toxicology | Neogen
Global Sufentanil (API) Market Professional Survey Report 2017 : ReportsnReports
Individual Probability of Allogeneic Erythrocyte Transfusion in Elective Spine Surgery:The Predictive Model of Transfusion in...
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab...
Effect of Delivery Route on the Pharmacokinetics of Sufentanil NanoTab(R) in Healthy Subjects - AdisInsight
Sublingual Sufentanil Demonstrates Efficacy for Acute Pain in ER Patients - MPR
Sufentanil Citrate (Professional Patient Advice) - Drugs.com
Leki refundowane - Cena i zamienniki leku Sufentanil Citrate
sufentanil | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection - Full Text View - ClinicalTrials...
Regional Anesthesia by Ashley Lamb on Prezi
Pharmaceutical Intermediates Powder Ocfentanil Acetylfentanyl Fentanyl Hcl Trefentanil Sufentanil - WANKE BIO-TECH CO., LIMITED...
WHEN HEPATITIS C WAS TRANSMITTED FROM PATIENT TO PATIENT - The anesthesia consultant
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab...
Author: Spadavecchia, C. / Subject: pain - PubAg Search Results
Anaesthesia UK : Oral case 119
11:28 am
Anæstesi til gynækologisk explorativ laparotomi + postoperativ smertebehandling
5??-Reductase | Beneficial Effects of RAF Inhibitor i
Sulfentanil Citrate
-
Anesthetics, Intravenous, Narcotics, Adjuvants, Anesthesia, Analgesics, Opioid, ...
Institute of Biomedical Engineering (IBT) - Publications
Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation...
Sufentanil Drug Interactions - Drugs.com
Braz J Cardiovasc Surg - Sufentanil Reduces Emergence Delirium in Children Undergoing Transthoracic Device...
Process for the Preparation of Sufentanil Base and Related Compounds - Patent application
AcelRx Pharmaceuticals Provides Guidance on 2017 Milestones for ARX-04, now known as DSUVIA™ in the United States, for the...
Intranasal Sufentanil/Midazolam Versus Ketamine/ Midazolam for Analgesia/Sedation: METHODS
Sufentanil influenced after glyburide started leaving the stage?
Sabinet | Attenuation of the haemodynamic response to placement of the Mayfield skull pin head holder : alfentanil versus scalp...
Most recent papers with the keyword aortic anesthesia | Read by QxMD
Preoperative anxiolysis in children
DURECT Corporation Announces Earnings and Reports Strong Progress on Its Business | DURECT Corporation
HP-VAS 0.5, 5.0, and 0.5-5.0, heat-as-pain visual analog score minimal threshold, intermediate threshold, and differential...
mylan - Trust Pharmacy
Anaesthesiologists and their drugs
Einfluss der patientenkontrollierten epiduralen Analgesie versus der patientenkontrollierten intravenösen Analgesie auf...
Brazilian Journal of Anesthesiology - Volume 59 / Issue 3
If somebody is suspected of having taken an overdose but has no symptoms.
This Week in Biotech -- The Motley Fool
I dont use #Fentanyl to get high. It l - narcoticablog
Intraoperative and postoperative anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture...
Indian Journal of Anaesthesia (IJA)
R-30490 - Wikipedia
Response to Letters Regarding Article, Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery | Circulation
Plus it
PCEA labor analgesia
Fentanyl 3x 67mcg | Alpha Med Shop®
What Kind of Drug is Fentanyl | What Is Fentanyl | Expomed
Pengaruh Pemberian Petidin Dan Fentanyl Sebagai Premedikasi Anestesi Terhadap Perubahan Tekanan Darah Di RSUD Prof. Dr. Margono...
SPECTRUM TCI 113583-35-0 - 49D081|D3101-5G - Grainger
Sufentanil
"Sufentanil". Drug Information Portal. U.S. National Library of Medicine. "Sufentanil citrate". Drug Information Portal. U.S. ... Sufentanil first was synthesized at Janssen Pharmaceutica in 1974. Sufentanil is marketed for use by specialist centers[ ... Sufentanil, sold under the brand names Dsuvia and Sufenta, is a synthetic opioid analgesic drug approximately 5 to 10 times as ... Sufentanil with and without lidocaine or mepivacaine is available as a transdermal patch similar to Duragesic in Europe under ...
Misuse of Drugs Act (Singapore)
... sufentanil, carfentanil, etc.) GHB Ketamine Lysergic acid diethylamide (LSD), and other lysergides MDMA (ecstasy) Mescaline ...
Midazolam
West JM, Estrada S, Heerdt M (July 1987). "Sudden hypotension associated with midazolam and sufentanil". Anesthesia and ...
Self-administration
Jaffe, A., Sharpe, L., & Jaffe, J. (1989). Rats self-administer sufentanil in aerosol form. Pharmacology, 289-293. Pilla M.; ...
Premedication
Sufentanil is also sometimes used as a premedication. Clonidine is becoming increasingly popular as a premedication for ...
Alfentanil
Methods for the synthesis of alfentanil, sufentanil, and remifentanil. US Patent 7,208,604 "From DEA website, accessed 23 Jan ...
Anesthetic
Philbin, DM; Rosow, CE; Schneider, RC; Koski, G; D'ambra, MN (1990). "Fentanyl and sufentanil anesthesia revisited: how much is ... Alfentanil Fentanyl Remifentanil Sufentanil, which is not available in Australia. The following agents have longer onset and ...
Betahydroxythiofentanyl
Sufentanil Thiafentanil Valter K, Arrizabalaga P. Designer Drugs Directory (1998), p150. ISBN 0-444-20525-X Henderson GL (1988 ...
History of general anesthesia
Niemegeers, CJ; Schellekens, KH; Van Bever, WF; Janssen, PA (1976). "Sufentanil, a very potent and extremely safe intravenous ... Fentanyl was followed by sufentanil (1974), alfentanil (1976), carfentanil (1976), and lofentanil (1980). Janssen and his team ...
Childbirth
Loftus JR, Hill H, Cohen SE (August 1995). "Placental transfer and neonatal effects of epidural sufentanil and fentanyl ...
Janssen Pharmaceuticals
Niemegeers CJ, Schellekens JH, van Bever WF, Janssen PA (1976). "Sufentanil, a very potent and extremely safe intravenous ...
Fentanyl
Meperidine is a fully synthetic opioid, and other members of the phenylpiperidine family like alfentanil and sufentanil are ... Fentanyl is a synthetic opioid in the phenylpiperidine family, which includes sufentanil, alfentanil, remifentanil, and ...
Lofentanil
Meert TF, Lu HR, van Craenndonck H, Janssen PA (September 1988). "Comparison between epidural fentanyl, sufentanil, carfentanil ... and short-acting derivatives such as sufentanil or remifentanil being preferred for medical use in human surgical procedures. ...
Carfentanil
... sufentanil, and thiafentanil. Over three hundred cases of overdose related to fentanyl and fentanyl analogues were reported ...
14-Methoxymetopon
... and less bradycardia than sufentanil in the dog". Anesthesia and Analgesia. 90 (6): 1359-64. doi:10.1097/00000539-200006000- ...
Thiophene
This is seen in examples such as the NSAID lornoxicam, the thiophene analog of piroxicam, and sufentanil, the thiophene analog ...
Remifentanil
... remifentanil TCI vs sufentanil TCI in morbid obesity. Br J Anaesth. 2007;99(3):404-411. Michelsen LG, Hug CC Jr. The ...
Thiafentanil
Sufentanil List of fentanyl analogues Bao-Shan Huang, Ross C. Terrell, Kirsten H. Deutsche, Linas V. Kudzma, Nhora L. Lalinde ( ...
Ticarcillin
... sufentanil, pizotyline etc.). One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to ...
Opium Law
... propiram psilocine psilocybine racemethorphan racemoramide racemorphan remifentanil rolicyclidine secobarbital sufentanil ...
List of opioids
N-Methylcarfentanil Mirfentanil Ocfentanil Ohmefentanyl Parafluorofentanyl Phenaridine R-30490 Remifentanil Sufentanil ...
Controlled Drugs and Substances Act
Sufentanil (N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl] propionanilide) Thiofentanyl (N-[1-[2-(2-thienyl)ethyl]-4- ...
Sedative
Oxymorphone Propoxyphene Remifentanil Sufentanil Tapentadol Tramadol Certain Neurosteroids Allopregnanolone Ganaxolone ...
List of MeSH codes (D03)
... sufentanil MeSH D03.383.621.270 - flecainide MeSH D03.383.621.280 - fluspirilene MeSH D03.383.621.300 - imino pyranoses MeSH ...
ATC code N01
Hexobarbital N01AF03 Thiopental QN01AF90 Thiamylal N01AG01 Narcobarbital N01AH01 Fentanyl N01AH02 Alfentanil N01AH03 Sufentanil ...
Opioid
Alphamethylfentanyl Alfentanil Sufentanil Remifentanil Carfentanyl Ohmefentanyl Benzimidazoles opioids are also known as ...
C22H30N2O2S
The molecular formula C22H30N2O2S (molar mass: 386.551 g/mol, exact mass: 386.2028 u) may refer to: Oliceridine Sufentanil This ...
JDTic
... though it failed to block the effects of the selective μ-opioid receptor agonist sufentanil across a wide range of doses in ...
Misuse of Drugs Act 1977
Sufentanil Tapentadol (added by 2010 Regulations) Thebacon Thebaine Tilidine Trimeperidine 4-Cyano-2-dimethylamino-4,4- ...
Moscow hostage crisis chemical agent
Thomas Zilker: It seems to be different from fentanyl, carfentanil and sufentanil, but it has to be, it has to have the potency ...
Tiempo de latencia óptimo de sufentanil para disminuir la respuesta hemodinámica a la intubación orotraqueal
Tiempo de latencia ptimo de sufentanil para disminuir la respuesta hemodin mica a la intubaci n orotraqueal Quintero M, ... Casati A, Fanelli G, Albertin A, Deni F, Danelli G, Grifoni F, Torri G. Small doses of remifentanil or sufentanil for blunting ... estado f sico ASA I y II en tres grupos de 15 sujetos de acuerdo al tiempo de latencia entre la administraci n de sufentanil y ...
Intradermal sufentanil does not improve lidocaine-induced local anesthesia<...
... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ...
Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia |...
Anaesthesia was induced with 0.5 μg/kg sufentanil, 2 mg/kg propofol and 0.1 mg/kg vecuronium. After endotracheal intubation and ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia. ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia. ...
Transient Muscular Spasm after a Large Dose of Intrathecal Sufentanil | Anesthesiology | American Society of Anesthesiologists
Transient Muscular Spasm after a Large Dose of Intrathecal Sufentanil J.-M. Malinovsky, MD; J.-M. Malinovsky, MD ... We injected sufentanil within 30 s. The needle caused no apparent discomfort to our patient, and there were no irritative ... Sufentanil can decrease the total dose of local anesthetic and prolong its effect after spinal anesthesia. The case reported ... Large doses of sufentanil are rare but clinically relevant because they can be accidentally injected intrathecally (as in our ...
DURECT Completes Dosing of the Phase I Pharmacokinetic Study for Its Sufentanil Patch Product and of the First Cohort of the...
DURECT Completes Dosing of the Phase I Pharmacokinetic Study for Its Sufentanil Patch Product and of the First Cohort of the ... Further, we anticipate that the small size of our sufentanil patch. (potentially as small as 1/5th the size of currently ... DURECTs TRANSDUR(TM)-based sufentanil patch. The Company also announced the. completion of dosing of the first cohort of the ... pharmacokinetic study for our TRANSDUR sufentanil patch. Our announced goal. for this program was to complete this study in the ...
Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with...
List of publications , Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac ... Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary ... Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with ...
DI-fusion Epidural sufentanil for postsurgical pain relief
ChemIDplus - 60561-17-3 - OJCZPLDERGDQRJ-UHFFFAOYSA-N - Sufentanil citrate [USAN:USP] - Similar structures search, synonyms,...
Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations
Morphine (Injection Route) Description and Brand Names - Mayo Clinic
This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in the diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. Dizziness, lightheadedness, or fainting may occur when you or your child get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness. This medicine may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Before having any kind of surgery ...
Sufenta (sufentanil) dosing, indications, interactions, adverse effects, and more
... sufentanil), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... sufentanil SL. sufentanil SL, sufentanil. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use ... sufentanil SL. Serious - Use Alternative (1)sufentanil SL, sufentanil. Either increases toxicity of the other by ... sufentanil and iloperidone both increase sedation. Use Caution/Monitor.. iloperidone increases levels of sufentanil by ...
Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain
... is similar to another sufentanil-containing anesthetic-analgesic that has been available in the Netherlands for decades. ... Sufentanil (Zalviso, Grunenthal GmbH) has received a European government endorsement for the treatment of postoperative pain. ... The active ingredient, sufentanil, is an opioid that produces analgesia via activation of μ-opioid receptors primarily within ... Cite this: Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain - Medscape - Jul 24, 2015. ...
Fentanyl Analog Screening Kit (FAS Kit) and Emergent Panels | CDC
Sufentanil Citrate Prices and Savings - Inside Rx
Sufentanil and Ketamine/Norketamine in Human Plasma
For sufentanil only 100 µL plasma and for Ketamine/Norketamine only 50 µL plasma need to be used due to the sensitivity of the ... Sufentanil with a calibration range of 0.250 to 250 pg/mL and Ketamine and its metabolite Norketamine with a calibration range ... Sufentanil and Ketamine/Norketamine in Human Plasma Thursday, 23 December 2021 More News ...
DEX With Propofol vs Propofol on Outcomes After CABG Surgery
Table 4 - Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-2014 - Volume 22, Number 6-June 2016 -...
WebWISER - Home
Sharing and Collaboration All platforms now provide the ability to share substances, substance data (e.g. Fire Fighting Procedures or Reactivities), protective distance maps, and reference documents. In addition, a public API is now available for third party integration.. To share from your device, select the share icon from the menu or tool bar. Then follow your devices instructions to share the link via an app (e.g. text message) or copy a link of the data to your clipboard. On WebWISER, copy the link from the menu or, in the case of more complex data (e.g. chemical reactivity and protective distance), select the appropriate "Copy Link" button.. Links can be shared from all platforms and opened directly on the iOS and Android platforms. If you dont have WISER installed on your device or are on the Windows platform, links will automatically be opened in WebWISER.. The public API is open, free to use, and is used to provide the sharing features listed above. Have questions? Please contact ...
Sural Nerve Block: Overview, Periprocedural Care, Technique
Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia...
This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil- ... Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia ... Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-In ... The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the ...
Data-independent screening method for 14 fentanyl analogs in whole blood and oral fluid using LC-QTOF-MS
Recently, fentanyl analogs account for significant number of opioid deaths in the United States. Routine forensic analyses are often unable to detect and differentiate these analogs due to low concentrations and presence of structural isomers. A data-independent screening method for 14 fentanyl anal …
Cetirizine (Intravenous Route) Side Effects - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
Zomig, Zomig Rapimelt (zolmitriptan) dosing, indications, interactions, adverse effects, and more
TEGretol CR Advanced Patient Information - Drugs.com
Chapter 893 Section 03 - 2007 Florida Statutes - The Florida Senate
Simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram in plasma using liquid...
A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, ... This method allows quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram, which is useful for research ... Simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram in plasma using liquid ...
Transient Synovitis Treatment & Management: Medical Care, Activity
Listing of Drugs Currently Regulated as New Drugs (The New Drugs List) - Canada.ca
A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart...
Alfentanil1
- During cardiopulmonary bypass (CPB) there was a fall in BN plasma concentrations, observations similar to reports on fentanyl, sufentanil and alfentanil. (who.int)
Fentanyl6
- Further, we anticipate that the small size of our sufentanil patch (potentially as small as 1/5th the size of currently marketed transdermal fentanyl patches for a therapeutically equivalent dose) may offer improved convenience for patients. (durect.com)
- A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto-doxapram. (ru.nl)
- This method allows quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram, which is useful for research as well as therapeutic drug monitoring, if applicable. (ru.nl)
- This time, however, the drug was sufentanil, five to 10 times stronger than fentanyl. (medpagetoday.com)
- Dsuvia contains sufentanil, which is five to 10 times stronger than fentanyl and 1,000 times more potent than morphine. (banyantreatmentcenter.com)
- 1998. Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. . (cornell.edu)
Sufenta1
- Unfortunately, a mistake between two syringes lead us to inject a 4-ml mixture containing 40 micro gram sufentanil (Sufenta, Janssen, Boulogue-Biffancourt, France) diluted with 0.9% saline. (asahq.org)
Remifentanil1
- Casati A, Fanelli G, Albertin A, Deni F, Danelli G, Grifoni F, Torri G. Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation: a double-blind comparison. (medigraphic.com)
Epidural2
- For these authors, epinephrine was responsible for irritative symptoms, and such effects have not been reported after intrathecal use of sufentanil without epinephrine [1,2] or in epidural use. (asahq.org)
- Background:The aim of this prospective, double blind, randomised trial was to compare the analgesic and adverse effectsof three concentrations of the thoracic epidural sufentanil with bupivacaine in patients undergoing thoracotomy.Methods:We studied 60 (randomised) patients who were to receive a 10 ml bolus dose of sufentanil, 1µg/ml, 2 µg/ml and3 µg/ml, in bupivacaine 0.125%, via thoracic epidural. (bvsalud.org)
Sublingual4
- Its lead product candidate is DSUVIA and DZUVEO, a 30 mcg sufentanil sublingual tablet for the treatment of moderate-to-severe acute pain. (yahoo.com)
- Zalviso is a pre-programmed, handheld device that delivers a sublingual formulation of Sufentanil, a synthetic opioid analgesic. (valueinvestorsclub.com)
- Dsuvia, the sublingual form of sufentanil or the form that's administered under the tongue, is used to manage acute pain in adults. (banyantreatmentcenter.com)
- The sublingual form of sufentanil was manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx) and was approved on November 2, 2018. (banyantreatmentcenter.com)
Opioid analgesic1
- Also known as Dsuvia, sufentanil is an opioid analgesic that's used as an anesthetic. (banyantreatmentcenter.com)
Propofol3
- In a prospective study midlatency somatosensory evoked potentials (SEP) were investigated in relation to explicit memory function during recovery from propofol/sufentanil anaesthesia. (biomedcentral.com)
- Anaesthesia was induced with 0.5 μg/kg sufentanil, 2 mg/kg propofol and 0.1 mg/kg vecuronium. (biomedcentral.com)
- After preoxygenation induction of anesthesia consisted of sufentanil 10mcg and 200mg propofol i.v. Endotracheal intubation was facilitated using 100mg succinylcholine i.v. The loaded Wuscope combined with EndoFlex tube introduced into the oropharynx and advanced toward the larynx. (ispub.com)
Produces analgesia2
- INTRATHECAL sufentanil produces analgesia without motor or sympathetic blockade. (asahq.org)
- The active ingredient, sufentanil, is an opioid that produces analgesia via activation of μ-opioid receptors primarily within the central nervous system. (medscape.com)
Concentrations1
- Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary artery bypass surgery with CPB. (utu.fi)
Zalviso2
- Sufentanil ( Zalviso , Grunenthal GmbH) has received a European government endorsement for the treatment of postoperative pain. (medscape.com)
- Shelf life' refers to the stability of the painkilling sufentanil tabs in the Zalviso system. (thestreet.com)
Bolus1
- Five minutes before sufentanil bolus (0.4 µg/kg), patients in group O received 0.02â mg/kg oxycodone intravenously within 5 s, those in group S received 0.02 µg/kg sufentanil within 5 s, and those in group N received an equal volume of 0.9% normal saline within 5 s. (bvsalud.org)
Anesthesia9
- We routinely use 10 micro gram sufentanil in addition to 5 or 10 mg hyperbaric bupivacaine for endoscopic urologic procedures, such as transurethral resection of the prostate or of bladder tumor, under spinal anesthesia. (asahq.org)
- Sufentanil can decrease the total dose of local anesthetic and prolong its effect after spinal anesthesia. (asahq.org)
- Spinal anesthesia was proposed, consisting of a 4-ml mixture containing 5 mg hyperbaric bupivacaine and 10 micro gram sufentanil diluted with 0.9% saline, prepared in the operating room. (asahq.org)
- Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial. (bvsalud.org)
- Sufentanil is widely used during anesthesia induction. (bvsalud.org)
- This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil -induced cough (SIC) during general anesthesia induction. (bvsalud.org)
- The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the anesthesia induction. (bvsalud.org)
- Preconditioning using intravenous oxycodone (0.02 mg/kg) or sufentanil (0.02 µg/kg) could represent an effective approach to reducing SIC in anesthesia induction and was associated with relatively stable hemodynamic state during general anesthesia . (bvsalud.org)
- Anesthesia was maintained with sevoflurane 1-2 MAC and incremental doses of sufentanil and cisatracurium. (ispub.com)
Hepatic2
- abametapir will increase the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- apalutamide will decrease the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Dose1
- The case reported here involved muscular spasm after accidental intrathecal injection of a large dose of sufentanil (40 micro gram). (asahq.org)
Anestesia1
- Analgésico opioide que se utiliza como coadyuvante en anestesia, en anestesia equilibrada y como agente anestésico primario. (bvsalud.org)
Ketamine3
- Sufentanil with a calibration range of 0.250 to 250 pg/mL and Ketamine and its metabolite Norketamine with a calibration range of 0.100 to 100 ng/mL can be determined in human plasma. (pharm-analyt.com)
- For sufentanil only 100 µL plasma and for Ketamine/Norketamine only 50 µL plasma need to be used due to the sensitivity of the LC-MS/MS assays. (pharm-analyt.com)
- Although most trials included in the review had methodological limitations, two randomized, double-blinded trials comparing the effects of prolonged ketamine and sufentanil infusions found no difference in the mean daily intracranial pressure and cerebral perfusion pressure of patients, all of whom had sustained traumatic brain injury. (boldcityem.com)
CYP3A41
- CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil. (cdc.gov)
Opioids1
- Sufentanil is a rapid onset opioid which typically doesn't get used as it peaks fast and is then metabolized by the liver very fast, making administering the drug very burdensome, even though it is highly efficacious and much safer than other opioids (multiple studies over time showing less oxygen desaturation, the most severe adverse event for opioids). (valueinvestorsclub.com)
Patch2
- Nasdaq: DRRX), an emerging specialty pharmaceuticals systems company, today announced the completion of dosing of the Phase I pharmacokinetic study for DURECT's TRANSDUR(TM)-based sufentanil patch. (durect.com)
- Today, we are pleased to announce the completion of dosing of the Phase I pharmacokinetic study for our TRANSDUR sufentanil patch. (durect.com)
Product1
- DURECT's TRANSDUR-based transdermal sufentanil product is intended to provide extended chronic pain relief for up to seven days, as compared to the three days of relief provided with currently available opioid patches. (durect.com)
Study1
- This study examined intradermally injected sufentanil (S), a highly lipid soluble opioid, administered with and without lidocaine (L), in a thermal pain model. (elsevier.com)
Pain1
- Cite this: Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain - Medscape - Jul 24, 2015. (medscape.com)
Generic1
- The opioid is a reformulated version of the long standing generic, Sufentanil, allowing it to be taken sublingually (ie under the tongue). (valueinvestorsclub.com)
Patients1
- In addition, 30% patients experienced pruritus in the 3 µg/ml sufentanilgroup compared with 10% and 5%, respectively, in the 2 µg/ml and 1 µg/ml sufentanil groups. (bvsalud.org)
Effect2
- Studies of the neurotoxicity of intrathecal sufentanil are controversial [5-7] but suggest that a direct effect cannot be excluded. (asahq.org)
- bremelanotide will decrease the level or effect of sufentanil by Other (see comment). (medscape.com)