An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
A widely used local anesthetic agent.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
Process of administering an anesthetic through injection directly into the bloodstream.
Procedure in which an anesthetic is injected directly into the spinal cord.
The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
Pain during the period after surgery.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
Period from the onset of true OBSTETRIC LABOR to the complete dilatation of the CERVIX UTERI.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth.
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
Methods of PAIN relief that may be used with or in place of ANALGESICS.
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.

Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. (1/224)

BACKGROUND: Sufentanil is a potent but short-acting spinal analgesic used to manage perioperative pain. This study evaluated the influence of transdermal nitroglycerine on the analgesic action of spinal sufentanil in patients undergoing orthopedic surgery. METHODS: Fifty-six patients were randomized to one of four groups. Patients were premedicated with 0.05-0.1 mg/kg intravenous midazolam and received 15 mg bupivacaine plus 2 ml of the test drug intrathecally (saline or 10 microg sufentanil). Twenty to 30 min after the spinal puncture, a transdermal patch of either 5 mg nitroglycerin or placebo was applied. The control group received spinal saline and transdermal placebo. The sufentanil group received spinal sufentanil and transdermal placebo. The nitroglycerin group received spinal saline and transdermal nitroglycerine patch. Finally, the sufentanil-nitroglycerin group received spinal sufentanil and transdermal nitroglycerine. Pain and adverse effects were evaluated using a 10-cm visual analog scale. RESULTS: The time to first rescue analgesic medication was longer for the sufentanil-nitroglycerin group (785+/-483 min) compared with the other groups (P<0.005). The time to first rescue analgesics was also longer for the sufentanil group compared with the control group (P<0.05). The sufentanil-nitroglycerin group group required less rescue analgesics in 24 h compared with the other groups (P<0.02) and had lesser 24-h pain visual analog scale scores compared with the control group (P<0.005), although these scores were similar to the sufentanil and nitroglycerin groups (P>0.05). The incidence of perioperative adverse effects was similar among groups (P>0.05). CONCLUSIONS: Transdermal nitroglycerine alone (5 mg/day), a nitric oxide generator, did not result in postoperative analgesia itself, but it prolonged the analgesic effect of spinal sufentanil (10 microg) and provided 13 h of effective postoperative analgesia after knee surgery.  (+info)

A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. (2/224)

BACKGROUND: This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. METHODS: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 ml bupivacaine, 0.125%, plus 7.5 microg sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 microg sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 microg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. RESULTS: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/-15 min and lasted +/-90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P<0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. CONCLUSIONS: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade.  (+info)

Effects of propofol, propofol-nitrous oxide and midazolam on cortical somatosensory evoked potentials during sufentanil anaesthesia for major spinal surgery. (3/224)

Recording of cortical somatosensory evoked potentials (CSEP) enables monitoring of spinal cord function. We studied the effects of propofol, propofol-nitrous oxide or midazolam during sufentanil anaesthesia on CSEP monitoring during major spinal surgery. Thirty patients with normal preoperative CSEP were allocated randomly to one of the following anaesthesia regimens: propofol (2.5 mg kg-1 followed by 10-6 mg kg-1 h-1) with or without nitrous oxide, or midazolam (0.3 mg kg-1 followed by 0.15 mg kg-1 h-1) combined with sufentanil 0.5 microgram kg-1 h-1 in the propofol and midazolam groups, or 0.25 microgram kg-1 h-1 in the propofol-nitrous oxide group. CSEP were elicited by alternate right and left tibial posterior nerve stimulation and recorded before and after induction (15 min, 1, 2 and 3 h), and during skin closure. CSEP latencies were not significantly modified in the three groups. CSEP amplitude decreased significantly in the propofol-nitrous oxide group (from mean 2.0 (SEM 0.3) to 0.6 (0.1) microV; P < 0.05) but not in the propofol (from 1.8 (0.6) to 2.2 (0.3) microV) or midazolam (1.7 (0.5) to 1.6 (0.5) microV) groups. The time to the first postoperative voluntary motor response (recovery) delay was significantly greater in the midazolam group (115 (19) min) compared with the propofol and propofol-nitrous oxide groups (43 (8) and 41 (3) min, respectively). Consequently, the use of propofol without nitrous oxide can be recommended during spinal surgery when CSEP monitoring is required.  (+info)

Intrathecal neostigmine and sufentanil for early labor analgesia. (4/224)

BACKGROUND: Recent efforts to improve the combined spinal epidural (CSE) technique have focused on adding opioids to other classes of analgesics. In this study, the authors used intrathecal neostigmine in combination with intrathecal sufentanil to investigate the usefulness of neostigmine for reducing side effects and prolonging the duration of sufentanil. METHODS: One hundred six healthy pregnant women in labor were enrolled in this study, which was divided into four phases. In all phases, patients received a CSE anesthetic while in the lateral position. In phase I, three groups of six women each received intrathecal neostigmine, 5, 10, or 20 microg, in an open-label, dose-escalating safety assessment. In phase II, 24 women received intrathecal sufentanil alone to establish an ED50 (dose that produces > 60 min of labor analgesia in 50% of patients). In phase III, an ED50 was established for sufentanil combined with a fixed dose of neostigmine (10 microg). In phase IV, 40 women received either twice the ED50 of sufentanil alone or twice the ED50 of sufentanil plus neostigmine, 10 microg. RESULTS: Neostigmine alone had no adverse effects on maternal vital signs, fetal heart rate, or Apgar scores. Neostigmine, 20 microg, produced analgesia in one patient and severe nausea and vomiting in another. The ED50 for intrathecal sufentanil alone was 4.1 +/- 0.31 microg, and the ED50 for intrathecal sufentanil combined with neostigmine, 10 microg, was 3.0 +/- 0.28 microg. The duration of analgesia and side effects from double these ED50s (sufentanil, 9 microg, or sufentanil, 6 microg, plus neostigmine, 10 microg) were similar between groups. CONCLUSIONS: The 10-microg intrathecal neostigmine dose alone produced no analgesia or side effects, but reduced the ED50 of intrathecal sufentanil by approximately 25%. Additionally, doses approximately double these ED50s each produced a similar duration of analgesia and side effects, indicating intrathecal neostigmine shifts the dose-response curve for intrathecal sufentanil to the left.  (+info)

Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients. (5/224)

BACKGROUND: The relative potencies of alfentanil, fentanyl, and sufentanil as a risk factor for postoperative nausea and vomiting have not been determined. They were compared in a randomized study designed to obtain equipotent plasma concentrations of these three opioids at the beginning of the recovery period. METHODS: The study included 274 patients treated on an outpatient basis. The steady state opioid plasma concentration providing a predicted 50% reduction of the minimum alveolar concentration of isoflurane was used to determine the relative potency of the opioids. The opioids were prepared in equal volumes at concentrations of alfentanil 150 microg/ml, fentanyl 50 microg/ml, and sufentanil 5 microg/ml and were administered in vol/kg. Anesthesia was induced in a blinded fashion with a bolus of the study opioid (0.05 ml/kg) and 4-6 mg/kg thiopental and was maintained with isoflurane (0.6-1%) in a nitrous oxide-oxygen mixture with a continuous infusion of the study opioid (0.06 ml x kg(-1) x h(-1)). If necessary, up to five additional boluses of opioid (0.02 ml/kg) could be given. This opioid administration protocol was tested by pharmacokinetic simulations. RESULTS: The incidence of postoperative nausea and vomiting was not different in the postanesthesia care unit, but in the ambulatory surgery unit it was significantly lower for alfentanil compared with fentanyl and sufentanil (12, 34, and 35%, respectively P < 0.005). Pharmacokinetic modeling showed that the end-anesthesia opioid plasma concentrations were approximately equipotent in the three groups. However, modeling does not support that the difference between groups in the postoperative period can be explained by a more rapid disappearance of alfentanil from the plasma. CONCLUSIONS: Alfentanil, compared with approximately equipotent doses of fentanyl and sufentanil, is associated with a lower incidence of postoperative nausea and vomiting in outpatients.  (+info)

Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. (6/224)

BACKGROUND: Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to characterize the rate and extent of opioid distribution within cerebrospinal fluid, spinal cord, epidural space, and systemic circulation after intrathecal injection. METHODS: Equal doses of morphine and alfentanil, fentanyl, or sufentanil were administered intrathecally (L3) to anesthetized pigs. Microdialysis probes were used to sample cerebrospinal fluid at L2, T11, T7, T3, and the epidural space at L2 every 5-10 min for 4 h. At the end of the experiment, spinal cord and epidural fat tissue were sampled, and each probe's recovery was determined in vitro. Using SAAM II pharmacokinetic modeling software (SAAM Institute, University of Washington, Seattle, WA), the data were fit to a 16-compartment model that was divided into four spinal levels, each of which consisted of a caternary arrangement of four compartments representing the spinal cord, cerebrospinal fluid, epidural space, and epidural fat. RESULTS: Model simulations revealed that the integral exposure (area under the curve divided by dose) of the spinal cord (i.e., effect compartment) to the opioids was highest for morphine because of its low spinal cord distribution volume and slow clearance into plasma The integral exposure of the spinal cord to the other opioids was relatively low, but for different reasons: alfentanil has a high clearance from spinal cord into plasma, fentanyl distributes rapidly into the epidural space and fat, and sufentanil has a high spinal cord volume of distribution. CONCLUSIONS: The four opioids studied demonstrate markedly different pharmacokinetic behavior, which correlates well with their pharmacodynamic behavior.  (+info)

Involvement of the cyclic AMP system in the switch from tolerance into supersensitivity to the antinociceptive effect of the opioid sufentanil. (7/224)

1. We have previously demonstrated that chronic and simultaneous treatment of rats with the mu-opioid receptor agonist sufentanil and the Ca(2+) channel blocker nimodipine, not only prevented tolerance development, but the animals became supersensitive to the antinociceptive effect of the opioid. The focus of the present work was to determine the possible involvement of cross interactions between the adenylyl cyclase pathway and L-type voltage-sensitive Ca(2+)-channels, in modulating the switch from opioid tolerance into supersensitivity. 2. The modulatory effect of sufentanil on adenylyl cyclase activity was determined by measuring cyclic AMP production in slices from the cortex of rats rendered tolerant or supersensitive to the antinociceptive effect of the opioid. Tolerance was induced by chronic infusion of sufentanil, at a rate of 2 microg h(-1), for 7 days. Supersensitivity was induced by concurrent infusion of sufentanil (2 microg h(-1)) and nimodipine (1 microg h(-1)) for 7 days. Antinociception was evaluated by the tail-flick test. 3. Tolerance to the analgesic effect of sufentanil was associated with a significant reduction in the response of adenylyl cyclase to forskolin. Furthermore, the effect of the opioid on forskolin-induced cyclic AMP accumulation was abolished. On the other hand, supersensitivity to the analgesic effect of the opioid was associated with an increase in both, the adenylyl cyclase response to forskolin, and the opioid inhibition of cyclic AMP production. 4. We suggest that sustained L-type Ca(2+) channel blockade may result in changes in the adenylyl cyclase effector system triggered by mu-opioid receptor activation, leading to the switch from opioid tolerance into supersensitivity.  (+info)

The dose-response of intrathecal sufentanil added to bupivacaine for labor analgesia. (8/224)

BACKGROUND: Regional analgesia for labor often is initiated with an intrathecal injection of a local anesthetic and opioid. The purpose of this prospective, randomized, blinded study was to determine the optimal dose of intrathecal sufentanil when combined with 2.5 mg bupivacaine for labor analgesia. METHODS: One hundred seventy parous parturients with cervical dilation between 3-5 cm were randomized to receive intrathecal 0 (control), 2.5, 5.0, 7.5, or 10.0 microg sufentanil combined with 2.5 mg bupivacaine, followed by a lidocaine epidural test dose, for initiation of analgesia (34 patients in each group). Visual analog scores and the presence of nausea, vomiting, and pruritus were determined every 15 min until the patient requested additional analgesia. Fetal heart rate tracings were compared between groups. RESULTS: Groups were similar for age, height, weight, oxytocin dose, duration of labor, and baseline visual analog scores. Duration of action was significantly shorter for control patients (39 +/- 25 min [mean +/- SD]) compared with those administered sufentanil, all doses (93 +/- 32, 93 +/- 47, 94 +/- 33, 97 +/- 39 min), but was not different among groups administered 2.5, 5.0, 7.5, or 10.0 microg sufentanil. More patients who received 10 microg sufentanil reported nausea and vomiting than did control patients. The severity of pruritus increased with administration of 7.5 and 10.0 microg sufentanil. There was no difference in fetal heart rate changes among groups. CONCLUSIONS: Intrathecal bupivacaine (2.5 mg) without sufentanil did not provide satisfactory analgesia for parous patients. However, bupivacaine combined with 2.5 microg sufentanil provided analgesia comparable to higher doses, with a lower incidence of nausea and vomiting and less severe pruritus.  (+info)

TY - JOUR. T1 - Sufentanil infusion before extubation suppresses coughing on emergence without delaying extubation time and reduces postoperative analgesic requirement without increasing nausea and vomiting after desflurane anesthesia. AU - Lee, Jea Yeun. AU - Lim, Byung Gun. AU - Park, Hye Yoon. AU - Kim, Nan Sook. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/6. Y1 - 2012/6. N2 - Background: Coughing, hypertension, tachycardia, and even laryngospasm can occur due to airway irritation during emergence from anesthesia. We investigated the effect of maintaining a sufentanil infusion during emergence from anesthesia by evaluating the incidence of cough and recovery profiles at extubation. Methods: In total, eighty-four patients undergoing an elective laparoscopic hysterectomy were randomly divided into two sufentanil groups and a control group. During emergence, sufentanil was administered in the sufentanil groups at a rate of 0.2 μg/kg/hr (Group S1) or 0.3 ...
Sufentanil (R30730, brand name Sufenta) is a synthetic opioid analgesic drug approximately 5 to 10 times more potent than its parent drug, fentanyl, and 500 times as potent as morphine. Structurally, sufentanil differs from fentanyl through the addition of a methoxymethyl group on the piperidine ring (which is believed to reduce duration of action), and the replacement of the phenyl ring by thiophene. Sufentanil first was synthesized at Janssen Pharmaceutica in 1974. Sufentanil is marketed for use by specialist centers under different trade names, such as Sufenta and Sufentil. Sufentanil with and without lidocaine or mepivacaine is available as a transdermal patch similar to Duragesic in Europe under trade names such as Chronogesic. The main use of this medication is in operating suites and critical care where pain relief is required for a short period of time. It also offers properties of sedation and this makes it a good analgesic component of anesthetic regimen during an operation. It is ...
SIMONI, Ricardo Francisco; PEREIRA, Antônio Márcio Sanfim Arantes; BOREGA, Renato dos Santos and SIMOES, Daniel Caldeira Pereira. Remifentanil versus Sufentanil em infusão contínua em intervenções cirúrgicas videolaparoscópicas: estudo comparativo. Rev. Bras. Anestesiol. [online]. 2008, vol.58, n.3, pp.193-201. ISSN 0034-7094. http://dx.doi.org/10.1590/S0034-70942008000300001.. JUSTIFICATIVA E OBJETIVOS: A infusão contínua (IC) de remifentanil na técnica de anestesia venosa total é prática comum. Já o sufentanil em IC para cirurgias de curta/média duração tem sido pouco utilizado. O objetivo desse estudo foi comparar duas técnicas de anestesia venosa total, utilizando remifentanil ou sufentanil em IC, quanto ao comportamento anestésico no intra-operatório e às características da recuperação anestésica em pacientes submetidos à videolaparoscopia. MÉTODO: Participaram desse estudo 60 pacientes divididos em 2 grupos iguais (GR e GS). O GR foi induzido com remifentanil IC ...
Sufentanil - Get up-to-date information on Sufentanil side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Sufentanil
This is a professional and in-depth study on the current state of the Global Sufentanil Industry with a focus on the Chinese market. The report provides key statistics on the market status of the Sufentanil manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2009-2014 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Sufentanil industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for ...
Craig M. Stoops, Charles A. Curtis, David A. Kovach, Richard L. McCammon, Robert K. Stoelting, Thomas M. Warren; HEMODYNAMIC EFFECTS OP BW A938U IN CORONARY ARTERY BYPASS GRAFT AND VALVE REPLACEMENT PATIENTS RECEIVING OXYGEN SUFENTANIL ANESTHESIA. Anesthesiology 1987;67(3):A368. Download citation file:. ...
The Companys follow on product candidate, ZALVISO® (sufentanil sublingual tablet system), designed for the management of moderate-to-severe acute pain in adult patients in the hospital setting, is currently enrolling patients in a Phase 3 clinical trial, IAP312. ZALVISO delivers 15 mcg sufentanil sublingually through a non-invasive delivery route via a pre-programmed, patient-controlled analgesia device. ZALVISO is approved in the EU for the management of acute postoperative pain in a hospital setting and is investigational and in late-stage development in the U.S ...
مجله علمی دانشگاه علوم پزشکی و خدمات درمانی بیرجند . داراي رتبه علمي- پژوهشي از كميسيون نشريات علوم پزشكي كشور Journal of Birjand University of Medical Sciencesfrom iran
Neogens Sufentanil ELISA (Enzyme-Linked ImmunoSorbent Assay) test kit is a qualitative one-step kit designed for use as a screening device for the detection of Sufentanil and Carfentanil. The kit was designed for screening purposes and is intended for forensic use only.. ...
[100 Pages Report] Check for Discount on Global Sufentanil (API) Market Professional Survey Report 2017 report by QYResearch Group. This report studies Sufentanil (API) in Global market, especially in...
Patients scheduled to undergo elective spine surgery were included. More than 50% of the patients had an American Society of Anesthesiologists physical status of II or III. Exclusion criteria were exclusive cervical spine surgery, one-level laminectomy, and polytrauma. Clinical management was at the discretion of the attending anesthesiologists and surgeons. In the operating room, patients were continuously monitored with electrocardioscopy, blood pressure monitoring, pulse oximetry, capnography, and esophageal temperature monitoring. A Bair Hugger device (Arizant, Eden Prairie, MN) was used, and fluids were warmed. Anesthesia was induced with propofol (1.5-2.5 mg/kg), sufentanil (15 μg), and atracurium (0.7 mg/kg) and was maintained by a continuous infusion of sufentanil and atracurium, with desflurane in a 50%-50% vol/vol O2-N2O gas mixture. The rate of the sufentanil infusion and the inspired concentration of desflurane were adjusted to maintain mean blood pressure between 50 and 70 mm Hg ...
This pivotal phase III trial investigated the efficacy and tolerability of sublingual sufentanil [ARX 01] in patients with acute postoperative pain after
This trial compared the pharmacokinetics of sufentanil administered via four routes (intravenous, sublingual, buccal and oral), in healthy subjects.
AcelRx announced topline results from the Phase 3 SAP302 study of ARX-04 (sufentanil sublingual tablet) for the treatment of moderate-to-severe acute pain associated with trauma or injury in patients presenting to the emergency department.
Professional guide for Sufentanil Citrate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Sprawdź ile zapłacisz za lek Sufentanil Citrate w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
The IUPHAR/BPS Guide to Pharmacology. sufentanil ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
A thoracic epidural catheter (T8-10) was placed in group E. A bolus of 8ml 1% lidocaine with 0.375% ropivacaine was administered 15min before skin incision, followed by 5-8 ml/hr infusion during surgery in group E.. Postoperative analgesia by PCEA in group E (concentration: 0.1% ropivacaine + 0.1μg/ml sufentanil, loading dose: 4ml, infusion rate: 8ml/hr, bolus: 4ml, 1hr limit: 16ml) and lasting for 48hr and PCIA in group G (concentration: 1μg/ml sufentanil, loading dose: 4ml, bolus: 2ml, 4hr limit: 30ml).. Both group received general anesthesia maintaining with 1-2% end tidal sevoflurane together with TCI of propofol (target plasma concentration, 2-3µg/ml), continuous infusion of remifentanil (0.10 - 0.20 μg/kg/min) and cis-atracurium intermittently as needed. ...
Zhang, W., Fang, C., Li, J., Geng, Q. T., Wang, S., Kang, F., ... & Wei, X. (2014). Single-Dose, Bilateral Paravertebral Block Plus Intravenous Sufentanil Analgesia in Patients With Esophageal Cancer Undergoing Combined Thoracoscopic-Laparoscopic Esophagectomy: A Safe and Effective Alternative. Journal of cardiothoracic and vascular anesthesia, 28(4), 978-984 ...
1. Hot sale products: 10.Products list: * Fentanyl products: 2,5-Dimethylfentanyl 3-Allylfentanyl 3-Methylbutyrfentanyl p-fluoroisobutyrfentanyl p-chloroisobutyrfentanyl Cyclopentylfentanyl Furanylethylfentanyl Methoxyacetylfentanyl Thenylfentanyl...
Clinical Case for Discussion: An anesthesia colleague of yours dilutes a 50-microgram ampoule of sufentanil with 9 cc of normal saline, so the final syringe concentration is 5 micrograms per cc. He then injects 10 micrograms of sufentanil from this syringe into the clean IV line of three different patients during his OR day. Is…
SPID-48 is the sum of the pain intensity difference (PID) over the 48 hour time period. A pain intensity score of 0 (no pain) to 10 (worse possible pain) is obtained before starting the study and throughout the 48 time period. The pain score at each assessment time is subtracted from the baseline pain score to provide the total sum score or SPID-48. A higher SPID-48 is better and indicates a reduction in pain intensity compared to the baseline score. The range of SPID48 scores were -232 to 326.. Time-weighted SPID48 = ∑ [T(i) - T(i-1)] x PID(i), where T(0) = Time 0 (baseline), T(i) is the scheduled or unscheduled assessment time, and PID(i) is the PID score at time i for i=0 to 48 hours.. Note: Active group n=114 and placebo group n=58, instead of active n=115 and placebo n=57, due to one active patient receiving placebo inadvertently. ...
The purpose of this study was to compare four epidural protocols for peri-operative analgesia in dogs undergoing tibial plateau levelling osteotomy. Forty client-owned dogs were randomly assigned to one of four treatments - groups R0.5 and R1 received 0.5mg/kg and 1mg/kg ropivacaine, respectively. Group SR0.5 received 1μg/kg sufentanil plus 0.5mg/kg ropivacaine, and group SER0.5 received 1μg/kg su ...
Intraoperative Course. I. Selection of monitors. 1. Compare invasive vs noninvasive monitors.. 2. When would you place the monitors?. 3. Discuss interpretation of PETCO2.. 4. How does this help with anesthetic management?. 5. Give reasons for discrepancy between paCO2 and PETCO2?. 6. What other monitors would you use? Explain.. 7. How will you decide if myocardial ischemia is occurring intraoperatively?. II. Selection and management of anesthetic techniques. 1. Do you prefer sufentanil for induction? Explain.. 2. What are your goals for induction?. 3. What are your drug choices for induction? Discuss your sequence, including reasons.. 4. You are unable to intubate initially, and the blood pressure increases to 180 systolic. What is the significance of this?. 5. What is your management?. 6. Marked bradycardia after intubation occurs. What are possible causes?. 7. Discuss your management.. 8. Should nitrous oxide be used? Explain your reasons.. 9. What are advantages and disadvantages of inhaled ...
At one point in AKA Its Called Whiskey, Jessica Jones saves her junkie neighbor Malcolm (Eka Darville) from a beating and he thanks her by saying, Youre a good person, Jessica Jones. Her response is quick, dismissive, and correct: Youre high. But is Jessica Jones a good person? Sure, shes trying to stop a mind-controlling maniac and save a young woman from a life behind bars, but are her noble intentions enough to make up for her less admirable choices? Does hunting Kilgrave excuse Jessica sleeping with the former husband of a woman she murdered while under Kilgraves control? Does getting her hands on Kilgraves weakness, the surgical anesthetic sufentanil, excuse her exploitation of Malcolm in order to acquire the drug? Jessica herself says no. During her date with Luke Cage (does going out for a meal between wild sex sessions count as a …. ...
Medicinblanding. Ropivacain 0,1% med Sufentanil 0,4 µg/ml i et totalt volumen på 100 ml. Programmering. Programmeret intermitterende bolus 6 ml. Interval 45 min. PCEA 5 ml. Lockout 10 min. Maksimal dosis 25 ml/time. OBS! Afhængigt af indgrebets størrelse og patientprofil pauseres den epidurale smertebehandling efter 1-3 dage. Efter 3-4 timers forløb evalueres, hvorvidt man kan seponere katetret, eller om der er behov for yderligere et par dages epidural analgesi. ...
In most pre-clinical animal research investigating stem cell therapy in severe myocardial infarction (AMI), the administered stem cells are isolated from healthy donors. sufentanil (50?g/kg) and medetomidine (150?m/kg) subcutaneously. Because these trials acquired to end up being performed under different aneasthesia, as hypnorm/dormicum was no obtainable much longer, an additional healthy control group was included. […]. ...
Sufentanil is a synthetic opioid analgesic. Sufentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Sufentanil may increase the patients tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Sufentanil depresses the respiratory centers, depresses the cough reflex, and constricts the pupils ...
Abstract:. PURPOSE: There is controversy about relevant EEG signal changes indicating adequate or inadequate anaesthesia. Differences of drug-induced and nociceptive mediated signal changes have not been studied in detail. The present study investigates whether signal changes during decreases of depth of anaesthesia due to surgical stimulation depend on different isoflurane concentrations during sufentanil anaesthesia. METHODS: Following IRB approval and written informed consent 28 patients (ASA: I; age 43 +/- 11 y) scheduled for elective abdominal surgery were included in the study. Anaesthesia: propofol (2.0 mg/kg) and sufentanil (1.0 micrograms/kg). Following endotracheal intubation (vecuronium 0.1 mg/kg) patients were normoventilated (P(ET)CO2: 36-38 mmHg). Randomly assigned to steady-state anaesthesia (group 1: P(ET)Isoflurane 0.2%, (14n); group 2: P(ET)Isoflurane 0.6%, (14n) during the start of surgery. Monitoring: heart rate (HF), mean arterial blood pressure (MAP), P(ET)CO2, arterial ...
Patients were sent to the surgical room without any premedication 30 min before the surgery. Standard monitoring consisted of five-lead electrocardiography (ECG), oxygen saturation (SpO2) and non-invasive blood pressure measurements. The anesthesiologist administering the anesthetic prepared a 50-ml syringe containing 4 μg/ml of DEX. A 20-gauge intravenous cannula was inserted in the dorsum of each patients left hand; 0.6 μg/kg of DEX was administered, and was changed to 0.4 μg/kg/h for maintenance after 15 min. Preoxygenation with 100% oxygen was administered before induction, which was delivered through a facial mask for no less than 3 min. After the arterial line was inserted under local anesthesia, general anesthesia was induced with 0.3 mg/kg of etomidate, 0.5 μg/kg of sufentanil and 1.2 mg/kg of rocuronium. Manual facemask ventilation was continued for no less than 4 min until the jaw was relaxed and the Bispectral Index Monitoring (BIS) was less than 50 to allow the double-lumen tube ...
772 medications are known to interact with sufentanil. Includes Acetylsalicylic Acid (aspirin), alfentanil, Baricon (barium sulfate).
Xu N, Chen Q, Huang S, Sun K, Cao H. Sufentanil Reduces Emergence Delirium in Children Undergoing Transthoracic Device Closure of VSD After Sevoflurane-Based Cardiac Anesthesia. Braz J Cardiovasc Surg. Ahead of Print ...
0009] The present disclosure is still further directed, in one preferred embodiment, to a process for preparing sufentanil base. The process comprises: (i) preparing a purified 4-(methoxymethyl)-N-phenyl-1-(2-(thiophen-2-yl)ethyl)piperidin-4-amine, the process comprising: (a) combining (4-phenylamino)-1-(2-(thiophen-2-yl)ethyl-piperidin-4-yl)methanol with a dispersion comprising about 60% by weight sodium hydride in the presence of an alcohol catalyst to form a first reaction mixture; (b) heating the first reaction mixture to a temperature between about 65° C. and about 70° C. for about 2 hours to deprotonate the (4-phenylamino)-1-(2-(thiophen-2-yl)ethyl-piperidin-4-yl)methanol; (c) adjusting the temperature of the resulting mixture containing the deprotonated (4-phenylamino)-1-(2-(thiophen-2-yl)ethyl-piperidin-4-yl)methanol to between about 5° C. and about 10° C.; (d) adding an alkylating agent to the temperature adjusted solution, while maintaining the temperature thereof to between about ...
for review. The Companys follow on product, ZALVISO® (sufentanil sublingual tablet system), designed for the management of moderate-to-severe acute pain in adult patients in the hospital setting, is currently enrolling patients in a Phase 3 clinical trial, IAP312. ZALVISO delivers 15 mcg sufentanil sublingually through a non-invasive delivery route via a pre-programmed, patient-controlled analgesia device. ZALVISO is approved in the EU and is investigational and in late-stage development in the U.S ...
The University Ethics Committee approved the study, and the parents signed written consent forms. Fifty healthy ASA status 1 children, free of any nasopharyngeal or respiratory problems, aged 5-7 years, weighing 15-20 kg, and having 6 or more teeth extracted, were eligible for participation in the study. Exclusion criteria were as follows: the use of analgesics or central nervous system depressants over the previous 24 hours; the use of anticoagulants; hypersensitivity to opioids, benzodiazepines, and ketamine, or any other medication likely to interfere with the study drugs. At a presurgery visit, patients were evaluated for inclusion, and baseline assessments (including a medical history) were performed. Patients were randomly allocated before surgery according to a computer-generated randomization list to 1 of 2 treatment groups. Children were fasted for 8 hours beforehand with only sips of clear fluid allowed 3-4 hours preinduction. In the S/M group, 25 children received intranasal ...
legacy pharmaceuticals packaging llc becomes first and only company to receive fda approval provided for generic glyburide. In view instead of this, experimental premedication with an iv dose of glyburide 30 min prior conduct to clotrimazole administration has supposedly been implemented clinically. This case discusses a pharmacokinetic interaction between the prodrug sirolimus and glyburide.
Introduction : Application of the Mayfield clamp causes a significant haemodynamic response. Different methods have been used to attenuate this response. We compared two of these methods, namely alfentanil bolus (Group A) and nerve block of the scalp (Group B). <br>Method : Twenty-two patients entered the study. Anaesthesia was standardised using thiopental, sufentanil, vecuronium, isoflurane, oxygen and air. Group A patients received alfentanil 10 mg kg&lt;sup&gt;-1&lt;/sup&gt; 90 seconds before clamp placement and group B patients received a scalp block with lignocaine 4-5 mg kg&lt;sup&gt;-1&lt;/sup&gt; as a 1% solution after intubation. Blood pressure and pulse rate were recorded before, during and 30 s, 60 s, 120 s, 240 s and 480 s after clamp placement. <br>Results : For group A, the mean maximum changes in systolic, diastolic and mean arterial blood pressure, and heart rate were, 34%, 39%, 35% and 20% respectively. The corresponding values for Group B
OBJECTIVE: Adjustment in the doses of opioids has been a focus of interest for achieving better fast-track conditions in cardiac anesthesia, but relatively sparse information exists on the potential effect of psychologic and behavioral factors, such as stress, anxiety, and type of personality, on anesthesia requirements and patient turnover in the cardiac recovery unit (CRU); to the authors knowledge, this particular focus has not been systematically investigated. In this randomized study, the authors tested the hypothesis that low-dose sufentanil, compared with a standard dose, can improve fast-track parameters and the overall quality of recovery ...
Virtually add sedating / analgesic medications can be used to sedate children prior to anesthesia, the important determinants are 1) available route 2) available agents 3) type/length of procedure 4) medical condition of the patient 5) psychological considerations (both family and patient) and 6) cost. The need for premedication does not begin until ~ 9 months at the earliest. Oral midazolam is the most commonly used agent in the US (0.25 to 1 mg/kg, not to exceed 20 mg). Alternatives when no IV access is yet available include nasal sufentanil (0.25 - 0.5 ucg/kg) and IM ketamine (3-4 mg/kg). Clonidine has also been successfully used in the pediatric patient population. Combination such as IM ketamine/atropine/midazolam (2-4 / 0.02 / 0.05 mg/kg) and oral ketamine/atropine/midazolam (4-6 / 0.02 / 0.5 mg/kg) have also been used to provide enhanced sedation. Ketamine up to 10 mg/kg IM may sometimes be required.. Oral agents are disadvantageous in that bioavailability may differ, and they require ...
CUPERTINO, Calif., Feb. 16 /PRNewswire/ -- DURECT Corporation (Nasdaq: DRRX) announced today financial results for the three months and year ended December 31, 2000 and reports strong progress in the companys business operations. The company reiterated its accelerated progress in the Phase II clinical trials for DUROS sufentanil and announced that it expects to complete patient enrollment before the end of second quarter 2001, which is approximately two months ahead of its previous timelines. The company estimates that a number of physicians active in the Phase II trial will also enroll participants in the Phase III trial, with a number of potential patients already identified for treatment. During the first half of 2001, DURECT will begin discussions with a major pharmaceutical company for a U.S. and Canada distribution relationship and has already initiated conversations with potential marketing partners outside of the U.S. DURECT has completed the development of a prototype clinical system ...
HP-VAS 0.5, 5.0, and 0.5-5.0, heat-as-pain visual analog score minimal threshold, intermediate threshold, and differential threshold expressing pain tolerance, ...
20 ml Rx only 6) Morphine Sulfate 9 mg/ml Sufentanil Cit 180 mcg/ml Bupivacaine HLC 33 mg/ml vol. Product Copaxone (glatiramer acetate injection 20 mg/1 mL, 1 mL pre-filled syringe. Tags: prednisone, handbags, website, prezzo, mylan. Prednisone 25 mg mylan prezzo handbags Herbals. ...
Chemical dependency is a disease that can affect all professions. Among the health care professionals, anesthesiologists represent a specific group. Numerous factors have been proposed to explain the high incidence of drug abuse among anesthesiologists. These include: easy access to potent drugs, particularly narcotics, highly addictive potential of agents with which they are in contact, and easy diversion of these agents since only small doses will initially provide an effect desired by the abuser. Opioids are the drugs of choice for anesthesiologists, and among them fentanyl and sufentanil are the most commonly used. Alcohol is mostly abused by older anesthesiologists. Propofol, ketamine, thiopental and midazolam are also abused. In fact, all but quaternary ammonium drugs can be observed. Signs and symptoms of addiction in the hospital workplace include: unusual changes in behavior, desire to work alone, refusal of lunch relief or breaks, volunteer for extra cases, call, come in early and ...
Surgeries accompanied by an extensive tissue trauma are associated with intense postsurgical pain and major perioperative homeostatic disorders. Both hyper-inflammatory and immuneparalytic reactions can be observed, what can negatively effect the postoperative course. To realise an effective and safe analgesia, epidural procedures are used to an increasing degree as an alternative method to the therapy with intravenous opioids. In this prospective, randomized, double-blinded trial we compared the patient-controlled epidural analgesia and the patient-controlled intravenous analgesia with respect to the analgesic efficiency and the influence on the postoperative immune competence. 54 patients received until the morning of the fourth postoperative day either ropivacaine plus sufentanil through an intraoperatively placed epidural catheter (PCEA-group) or intravenous morphine (PCIA-group). Cortisol, populations of leukocytes and lymphocytes, cell-surface molecules of monocytes and the soluble ...
Rev. Bras. Anestesiol., vol.59 n3, 261-272, 2009 Epidural block for cesarean section: a comparative study between 0.5% racemic Bupivacaine (S50-R50) and 0.5% enantiomeric excess Bupivacaine (S75-R25) associated with Sufentanil Angélica de Fátima de Assunção Braga; José Aristeu F. Frias; Franklin Sarmento da Silva Braga; Rosa Inês Costa Pereira; Mayla F Blumer; Marcia F Ferreira Scientific Article ...
Acetaminophen Poisoning Treatment Treatment in the crisis department depends upon the condition of the individual and any other medications taken. If somebody is suspected of having taken an overdose but has no symptoms, the doctor can start the following treatment: Emptying of the tummy: In the few cases when a person comes to a healthcare facility minutes after taking the overdose, the doctor may attempt to empty the tummy. This can be accomplished by inducing vomiting or by placing a large tube through the person`s mouth and in to the stomach, putting liquid in and pumping it out cheap generic cialis .. Zalviso is usually a drug-device combination product using the opioid agonist sufentanil formulated in a proprietary sublingual tablet formulation and shipped through a pre-programmed, non-invasive proprietary delivery device. AcelRx provides partnered with the Grunenthal Group to commercialize Zalviso in europe and Australia. AcelRx acquired previously announced that in July 2014, Grunenthal ...
Heralding the charge higher was AcelRx Pharmaceuticals (NASDAQ:ACRX) which advanced 18% on the week after disclosing on Tuesday that its post-operative pain management system, Sufentanil NanoTab PCA, met its primary endpoint in late-stage trials and reconfirmed all previous late-stage study results. This data is strong enough for AcelRx to seek approval from the Food and Drug Administration with a new drug application filing expected next quarter. Id be cautious with AcelRx moving forward, as the possibility of an FDA rejection for opioid-based treatments is always a possibility.. Also gaining double digits on the week was the highly embattled Peregrine Pharmaceuticals (NASDAQ:PPHM) which rallied after the FDA approved its late-stage trial design for its second-line non-small-cell lung cancer immunotherapy, Bavituximab. While trial design approvals are rarely big news, it is in this case because mid-stage results for Bavituximab have been all over the place. At first Bavituximab demonstrated a ...
I dont use #Fentanyl to get high. It lets me lets me live without #ChronicPain via The Globe and Mail http://htl.li/XTH030bEay2
Methods In a blinded clinical trial, 92 patients scheduled for supratentorial craniotomy under general anaesthesia were randomly allocated into either a multipoint TEAS (n=46) or a sham TEAS group (n=46). All patients received total intravenous anaesthesia (TIVA) with propofol and sufentanil. The target concentration of sufentanil was adjusted and recorded according to mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS). Patients in the TEAS group received TEAS 30 min before anaesthesia induction and this was maintained throughout the operation at four pairs of acupuncture points. Postoperative pain, recovery and side effects were evaluated. ...
Advances in the field of labour analgesia have tread a long journey from the days of ether and chloroform in 1847 to the present day practice of comprehensive programme of labour pain management using evidence-based medicine. Newer advances include introduction of newer techniques like combined spinal epidurals, low-dose epidurals facilitating ambulation, pharmacological advances like introduction of remifentanil for patient-controlled intravenous analgesia, introduction of newer local anaesthetics and adjuvants like ropivacaine, levobupivacaine, sufentanil, clonidine and neostigmine, use of inhalational agents like sevoflourane for patient-controlled inhalational analgesia using special vaporizers, all have revolutionized the practice of pain management in labouring parturients. Technological advances like use of ultrasound to localize epidural space in difficult cases minimizes failed epidurals and introduction of novel drug delivery modalities like patient-controlled epidural analgesia (PCEA) ...
R-30490 (also known as 4-Methoxymethylfentanyl) is an opioid analgesic related to the highly potent animal tranquilizer carfentanil, and with only slightly lower potency. It was first synthesised by a team of chemists at Janssen Pharmaceutica led by Paul Janssen, who were investigating the structure-activity relationships of the fentanyl family of drugs. R-30490 was found to be the most selective agonist for the μ-opioid receptor out of all the fentanyl analogues tested, but it has never been introduced for medical use in humans, although the closely related drug sufentanil is widely used for analgesia and anesthesia during major surgery. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and ...
We thank Hyder and colleagues for their careful, insightful reviews and thoughtful comments on our study that demonstrated that perioperative dexmedetomidine use is associated with better outcomes after cardiac surgery.1 We reported on the impact of a dexmedetomidine infusion started in the operating room after patients were separated from cardiopulmonary bypass. Because this was a retrospective, single-center study, all of the patients in both groups were managed in a similar fashion throughout the perioperative period. Intraoperative anesthesia management was consistent among our cardiac anesthesiologists, with an institutional standard of a moderate dose of narcotic (fentanyl or sufentanil) supplemented by a volatile anesthetic agent. Similarly, postoperative sedation in the intensive care unit was at the discretion of the intensive care unit care team, but the institutional protocol is infusions of fentanyl or midazolam supplemented by propofol when necessary for patient comfort. This ...
Electrophysiological recording. In a first set of animals, quantitative electrophysiological recording terminal experiments were performed on seven adult macaque monkeys (Macaca fascicularis or M. mulatta). All procedures conformed to British Home Office and United States National Institute of Health guidelines. Animals were premedicated with atropine sulfate (0.02-0.04 mg/kg) and acepromazine maleate (0.05 mg/kg) and preanesthetized with ketamine (10-30 mg/kg, i.m.). The trachea and saphenous veins were cannulated; the animal was artificially ventilated with room air or with a 50:50 mixture of O2 and N2O; and anesthesia was maintained by continuous intravenous infusion of sufentanil citrate (4-8 μg · kg−1 · hr−1). The animals head was fixed to a stereotaxic apparatus; a small craniotomy and durotomy were made over the occipital cortex; and a tungsten-in-glass microelectrode (Merril and Ainsworth, 1972) was positioned over the exposed cortex, which was then covered with warm agar. To ...
OpenAnesthesia™ content is intended for educational purposes only and not intended as medical advice.. Reuse of OpenAnesthesia™ content for commercial purposes of any kind is prohibited. ...
Buy Fentanyl 3x 67mcg online Product: Fentanyl 3x 67mcg Each order unit contains: Fentanyl 3x 67mcg Active substance: Fentanyl Manufacturer / Brand: Hexal AG Buy Fentanyl 3x 67mcg Hexal AG
Uncover what kind of drug Fentanyl is. We cover the legal and illegal uses, chemistry, and side effects of Fentanyl. Learn more about the dangers of Fentanyl.
Pengaruh Pemberian Petidin Dan Fentanyl Sebagai Premedikasi Anestesi Terhadap Perubahan Tekanan Darah Di RSUD Prof. Dr. Margono Soekarjo
Looking for SPECTRUM TCI 113583-35-0 (49D081)? Graingers got your back. Price:$174.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
"Sufentanil". Drug Information Portal. U.S. National Library of Medicine. "Sufentanil citrate". Drug Information Portal. U.S. ... Sufentanil first was synthesized at Janssen Pharmaceutica in 1974. Sufentanil is marketed for use by specialist centers[ ... Sufentanil, sold under the brand names Dsuvia and Sufenta, is a synthetic opioid analgesic drug approximately 5 to 10 times as ... Sufentanil with and without lidocaine or mepivacaine is available as a transdermal patch similar to Duragesic in Europe under ...
... sufentanil, carfentanil, etc.) GHB Ketamine Lysergic acid diethylamide (LSD), and other lysergides MDMA (ecstasy) Mescaline ...
West JM, Estrada S, Heerdt M (July 1987). "Sudden hypotension associated with midazolam and sufentanil". Anesthesia and ...
Jaffe, A., Sharpe, L., & Jaffe, J. (1989). Rats self-administer sufentanil in aerosol form. Pharmacology, 289-293. Pilla M.; ...
Sufentanil is also sometimes used as a premedication. Clonidine is becoming increasingly popular as a premedication for ...
Methods for the synthesis of alfentanil, sufentanil, and remifentanil. US Patent 7,208,604 "From DEA website, accessed 23 Jan ...
Philbin, DM; Rosow, CE; Schneider, RC; Koski, G; D'ambra, MN (1990). "Fentanyl and sufentanil anesthesia revisited: how much is ... Alfentanil Fentanyl Remifentanil Sufentanil, which is not available in Australia. The following agents have longer onset and ...
Sufentanil Thiafentanil Valter K, Arrizabalaga P. Designer Drugs Directory (1998), p150. ISBN 0-444-20525-X Henderson GL (1988 ...
Niemegeers, CJ; Schellekens, KH; Van Bever, WF; Janssen, PA (1976). "Sufentanil, a very potent and extremely safe intravenous ... Fentanyl was followed by sufentanil (1974), alfentanil (1976), carfentanil (1976), and lofentanil (1980). Janssen and his team ...
Loftus JR, Hill H, Cohen SE (August 1995). "Placental transfer and neonatal effects of epidural sufentanil and fentanyl ...
Niemegeers CJ, Schellekens JH, van Bever WF, Janssen PA (1976). "Sufentanil, a very potent and extremely safe intravenous ...
Meperidine is a fully synthetic opioid, and other members of the phenylpiperidine family like alfentanil and sufentanil are ... Fentanyl is a synthetic opioid in the phenylpiperidine family, which includes sufentanil, alfentanil, remifentanil, and ...
Meert TF, Lu HR, van Craenndonck H, Janssen PA (September 1988). "Comparison between epidural fentanyl, sufentanil, carfentanil ... and short-acting derivatives such as sufentanil or remifentanil being preferred for medical use in human surgical procedures. ...
... sufentanil, and thiafentanil. Over three hundred cases of overdose related to fentanyl and fentanyl analogues were reported ...
... and less bradycardia than sufentanil in the dog". Anesthesia and Analgesia. 90 (6): 1359-64. doi:10.1097/00000539-200006000- ...
This is seen in examples such as the NSAID lornoxicam, the thiophene analog of piroxicam, and sufentanil, the thiophene analog ...
... remifentanil TCI vs sufentanil TCI in morbid obesity. Br J Anaesth. 2007;99(3):404-411. Michelsen LG, Hug CC Jr. The ...
Sufentanil List of fentanyl analogues Bao-Shan Huang, Ross C. Terrell, Kirsten H. Deutsche, Linas V. Kudzma, Nhora L. Lalinde ( ...
... sufentanil, pizotyline etc.). One synthesis began by making the monobenzyl ester of 3-Thienylmalonic acid, converting this to ...
... propiram psilocine psilocybine racemethorphan racemoramide racemorphan remifentanil rolicyclidine secobarbital sufentanil ...
N-Methylcarfentanil Mirfentanil Ocfentanil Ohmefentanyl Parafluorofentanyl Phenaridine R-30490 Remifentanil Sufentanil ...
Sufentanil (N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl] propionanilide) Thiofentanyl (N-[1-[2-(2-thienyl)ethyl]-4- ...
Oxymorphone Propoxyphene Remifentanil Sufentanil Tapentadol Tramadol Certain Neurosteroids Allopregnanolone Ganaxolone ...
... sufentanil MeSH D03.383.621.270 - flecainide MeSH D03.383.621.280 - fluspirilene MeSH D03.383.621.300 - imino pyranoses MeSH ...
Hexobarbital N01AF03 Thiopental QN01AF90 Thiamylal N01AG01 Narcobarbital N01AH01 Fentanyl N01AH02 Alfentanil N01AH03 Sufentanil ...
Alphamethylfentanyl Alfentanil Sufentanil Remifentanil Carfentanyl Ohmefentanyl Benzimidazoles opioids are also known as ...
The molecular formula C22H30N2O2S (molar mass: 386.551 g/mol, exact mass: 386.2028 u) may refer to: Oliceridine Sufentanil This ...
... though it failed to block the effects of the selective μ-opioid receptor agonist sufentanil across a wide range of doses in ...
Sufentanil Tapentadol (added by 2010 Regulations) Thebacon Thebaine Tilidine Trimeperidine 4-Cyano-2-dimethylamino-4,4- ...
Thomas Zilker: It seems to be different from fentanyl, carfentanil and sufentanil, but it has to be, it has to have the potency ...
Tiempo de latencia ptimo de sufentanil para disminuir la respuesta hemodin mica a la intubaci n orotraqueal Quintero M, ... Casati A, Fanelli G, Albertin A, Deni F, Danelli G, Grifoni F, Torri G. Small doses of remifentanil or sufentanil for blunting ... estado f sico ASA I y II en tres grupos de 15 sujetos de acuerdo al tiempo de latencia entre la administraci n de sufentanil y ...
... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ... sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference ( ...
Anaesthesia was induced with 0.5 μg/kg sufentanil, 2 mg/kg propofol and 0.1 mg/kg vecuronium. After endotracheal intubation and ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia. ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia ... Midlatency somatosensory evoked potentials and explicit memory functions during recovery from propofol/sufentanil anaesthesia. ...
Transient Muscular Spasm after a Large Dose of Intrathecal Sufentanil J.-M. Malinovsky, MD; J.-M. Malinovsky, MD ... We injected sufentanil within 30 s. The needle caused no apparent discomfort to our patient, and there were no irritative ... Sufentanil can decrease the total dose of local anesthetic and prolong its effect after spinal anesthesia. The case reported ... Large doses of sufentanil are rare but clinically relevant because they can be accidentally injected intrathecally (as in our ...
DURECT Completes Dosing of the Phase I Pharmacokinetic Study for Its Sufentanil Patch Product and of the First Cohort of the ... Further, we anticipate that the small size of our sufentanil patch. (potentially as small as 1/5th the size of currently ... DURECTs TRANSDUR(TM)-based sufentanil patch. The Company also announced the. completion of dosing of the first cohort of the ... pharmacokinetic study for our TRANSDUR sufentanil patch. Our announced goal. for this program was to complete this study in the ...
List of publications , Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac ... Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary ... Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with ...
Epidural sufentanil for postsurgical pain relief. par Verborgh, Christian;Van Der Auwera, Daniel ;Van Droogenbroek, E.;Camu, ...
Sufentanil citrate [USAN:USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. ... Substance Name: Sufentanil citrate [USAN:USP]. RN: 60561-17-3. UNII: S9ZFX8403R. InChIKey: OJCZPLDERGDQRJ-UHFFFAOYSA-N. Note. * ...
DSUVIA (SUFENTANIL CITRATE) EQ 0.03MG BASE Marketing Status: Prescription Active Ingredient: SUFENTANIL CITRATE Proprietary ...
This medicine may be habit-forming. If you or your child feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions. Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you or your child to take laxatives, drink a lot of fluids, or increase the amount of fiber in the diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. Dizziness, lightheadedness, or fainting may occur when you or your child get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness. This medicine may make you dizzy, drowsy, confused, or disoriented. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Before having any kind of surgery ...
... sufentanil), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... sufentanil SL. sufentanil SL, sufentanil. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use ... sufentanil SL. Serious - Use Alternative (1)sufentanil SL, sufentanil. Either increases toxicity of the other by ... sufentanil and iloperidone both increase sedation. Use Caution/Monitor.. iloperidone increases levels of sufentanil by ...
... is similar to another sufentanil-containing anesthetic-analgesic that has been available in the Netherlands for decades. ... Sufentanil (Zalviso, Grunenthal GmbH) has received a European government endorsement for the treatment of postoperative pain. ... The active ingredient, sufentanil, is an opioid that produces analgesia via activation of μ-opioid receptors primarily within ... Cite this: Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain - Medscape - Jul 24, 2015. ...
Sufentanil. Tetrahydrofuran fentanyl 3-tetrahydrofurancarboxamide (hydrochloride). (±)-cis-3-methyl Thiofentanyl (hydrochloride ...
Compare prices for Sufentanil Citrate and save up to 80% using Inside Rx. Sufentanil Citrate prices starting at $10.08. ...
For sufentanil only 100 µL plasma and for Ketamine/Norketamine only 50 µL plasma need to be used due to the sensitivity of the ... Sufentanil with a calibration range of 0.250 to 250 pg/mL and Ketamine and its metabolite Norketamine with a calibration range ... Sufentanil and Ketamine/Norketamine in Human Plasma Thursday, 23 December 2021 More News ...
Sufentanil, μg. 271(242,300). 267(233,292). 0.001. Propofol, mg. 1105.49(633-2067). ...
Sufentanil, fentanyl, midazolam, vecuronium. Fungemia, endophthalmitis. OR. Yes. Sebert et al., 2002.. Case-control. ND. ND. ...
Sharing and Collaboration All platforms now provide the ability to share substances, substance data (e.g. Fire Fighting Procedures or Reactivities), protective distance maps, and reference documents. In addition, a public API is now available for third party integration.. To share from your device, select the share icon from the menu or tool bar. Then follow your devices instructions to share the link via an app (e.g. text message) or copy a link of the data to your clipboard. On WebWISER, copy the link from the menu or, in the case of more complex data (e.g. chemical reactivity and protective distance), select the appropriate "Copy Link" button.. Links can be shared from all platforms and opened directly on the iOS and Android platforms. If you dont have WISER installed on your device or are on the Windows platform, links will automatically be opened in WebWISER.. The public API is open, free to use, and is used to provide the sharing features listed above. Have questions? Please contact ...
2010dsuvia-sufentanil-sl-999947Drugs. Drugs sufentanil SL Need a Curbside Consult? Share cases and questions with Physicians on ...
This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil- ... Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia ... Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-In ... The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the ...
Recently, fentanyl analogs account for significant number of opioid deaths in the United States. Routine forensic analyses are often unable to detect and differentiate these analogs due to low concentrations and presence of structural isomers. A data-independent screening method for 14 fentanyl anal …
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
sufentanil SL. Monitor Closely (1)sufentanil SL, zolmitriptan. Either increases effects of the other by serotonin levels. Use ... sufentanil SL. sufentanil SL, zolmitriptan. Either increases effects of the other by serotonin levels. Use Caution/Monitor. ...
Detailed drug Information for TEGretol CR. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Sufentanil. (c) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or ...
A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, ... This method allows quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram, which is useful for research ... Simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram in plasma using liquid ...
2010dsuvia-sufentanil-sl-999947Drugs. Drugs sufentanil SL * 2010olinvyk-oliceridine-1000264Drugs. Drugs oliceridine ...
Health Canada list representing substances and formulations which have been assessed on the basis of an application to market or further to promotion of products for medicinal purposes where safety and efficacy for such purposes have not been established
Monk, J. P., Beresford, R. & Ward, A. Sufentanil. A review of its pharmacological properties and therapeutic use. Drugs 36, 286 ... Influence of cardiac output on the pharmacokinetics of sufentanil in anesthetized pigs. Anesthesiology 128, 912-920 (2018). ...
excluding, Alfentanil, Carfentanil, Fentanyl, and Sufentanil; including, but not limited to:. (I) Acetyl-alpha-methylfentanyl. ...
  • During cardiopulmonary bypass (CPB) there was a fall in BN plasma concentrations, observations similar to reports on fentanyl, sufentanil and alfentanil. (who.int)
  • Further, we anticipate that the small size of our sufentanil patch (potentially as small as 1/5th the size of currently marketed transdermal fentanyl patches for a therapeutically equivalent dose) may offer improved convenience for patients. (durect.com)
  • A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto-doxapram. (ru.nl)
  • This method allows quantification of fentanyl, sufentanil, cefazolin, doxapram and keto-doxapram, which is useful for research as well as therapeutic drug monitoring, if applicable. (ru.nl)
  • This time, however, the drug was sufentanil, five to 10 times stronger than fentanyl. (medpagetoday.com)
  • Dsuvia contains sufentanil, which is five to 10 times stronger than fentanyl and 1,000 times more potent than morphine. (banyantreatmentcenter.com)
  • 1998. Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. . (cornell.edu)
  • Unfortunately, a mistake between two syringes lead us to inject a 4-ml mixture containing 40 micro gram sufentanil (Sufenta, Janssen, Boulogue-Biffancourt, France) diluted with 0.9% saline. (asahq.org)
  • Casati A, Fanelli G, Albertin A, Deni F, Danelli G, Grifoni F, Torri G. Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation: a double-blind comparison. (medigraphic.com)
  • For these authors, epinephrine was responsible for irritative symptoms, and such effects have not been reported after intrathecal use of sufentanil without epinephrine [1,2] or in epidural use. (asahq.org)
  • Background:The aim of this prospective, double blind, randomised trial was to compare the analgesic and adverse effectsof three concentrations of the thoracic epidural sufentanil with bupivacaine in patients undergoing thoracotomy.Methods:We studied 60 (randomised) patients who were to receive a 10 ml bolus dose of sufentanil, 1µg/ml, 2 µg/ml and3 µg/ml, in bupivacaine 0.125%, via thoracic epidural. (bvsalud.org)
  • Its lead product candidate is DSUVIA and DZUVEO, a 30 mcg sufentanil sublingual tablet for the treatment of moderate-to-severe acute pain. (yahoo.com)
  • Zalviso is a pre-programmed, handheld device that delivers a sublingual formulation of Sufentanil, a synthetic opioid analgesic. (valueinvestorsclub.com)
  • Dsuvia, the sublingual form of sufentanil or the form that's administered under the tongue, is used to manage acute pain in adults. (banyantreatmentcenter.com)
  • The sublingual form of sufentanil was manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx) and was approved on November 2, 2018. (banyantreatmentcenter.com)
  • In a prospective study midlatency somatosensory evoked potentials (SEP) were investigated in relation to explicit memory function during recovery from propofol/sufentanil anaesthesia. (biomedcentral.com)
  • Anaesthesia was induced with 0.5 μg/kg sufentanil, 2 mg/kg propofol and 0.1 mg/kg vecuronium. (biomedcentral.com)
  • After preoxygenation induction of anesthesia consisted of sufentanil 10mcg and 200mg propofol i.v. Endotracheal intubation was facilitated using 100mg succinylcholine i.v. The loaded Wuscope combined with EndoFlex tube introduced into the oropharynx and advanced toward the larynx. (ispub.com)
  • INTRATHECAL sufentanil produces analgesia without motor or sympathetic blockade. (asahq.org)
  • The active ingredient, sufentanil, is an opioid that produces analgesia via activation of μ-opioid receptors primarily within the central nervous system. (medscape.com)
  • Neither total nor unbound sufentanil concentrations remained constant when performing a TCI with the Gepts model in coronary artery bypass surgery with CPB. (utu.fi)
  • Sufentanil ( Zalviso , Grunenthal GmbH) has received a European government endorsement for the treatment of postoperative pain. (medscape.com)
  • Shelf life' refers to the stability of the painkilling sufentanil tabs in the Zalviso system. (thestreet.com)
  • Five minutes before sufentanil bolus (0.4 µg/kg), patients in group O received 0.02â mg/kg oxycodone intravenously within 5 s, those in group S received 0.02 µg/kg sufentanil within 5 s, and those in group N received an equal volume of 0.9% normal saline within 5 s. (bvsalud.org)
  • We routinely use 10 micro gram sufentanil in addition to 5 or 10 mg hyperbaric bupivacaine for endoscopic urologic procedures, such as transurethral resection of the prostate or of bladder tumor, under spinal anesthesia. (asahq.org)
  • Sufentanil can decrease the total dose of local anesthetic and prolong its effect after spinal anesthesia. (asahq.org)
  • Spinal anesthesia was proposed, consisting of a 4-ml mixture containing 5 mg hyperbaric bupivacaine and 10 micro gram sufentanil diluted with 0.9% saline, prepared in the operating room. (asahq.org)
  • Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial. (bvsalud.org)
  • Sufentanil is widely used during anesthesia induction. (bvsalud.org)
  • This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil -induced cough (SIC) during general anesthesia induction. (bvsalud.org)
  • The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the anesthesia induction. (bvsalud.org)
  • Preconditioning using intravenous oxycodone (0.02 mg/kg) or sufentanil (0.02 µg/kg) could represent an effective approach to reducing SIC in anesthesia induction and was associated with relatively stable hemodynamic state during general anesthesia . (bvsalud.org)
  • Anesthesia was maintained with sevoflurane 1-2 MAC and incremental doses of sufentanil and cisatracurium. (ispub.com)
  • abametapir will increase the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • apalutamide will decrease the level or effect of sufentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • The case reported here involved muscular spasm after accidental intrathecal injection of a large dose of sufentanil (40 micro gram). (asahq.org)
  • Analgésico opioide que se utiliza como coadyuvante en anestesia, en anestesia equilibrada y como agente anestésico primario. (bvsalud.org)
  • Sufentanil with a calibration range of 0.250 to 250 pg/mL and Ketamine and its metabolite Norketamine with a calibration range of 0.100 to 100 ng/mL can be determined in human plasma. (pharm-analyt.com)
  • For sufentanil only 100 µL plasma and for Ketamine/Norketamine only 50 µL plasma need to be used due to the sensitivity of the LC-MS/MS assays. (pharm-analyt.com)
  • Although most trials included in the review had methodological limitations, two randomized, double-blinded trials comparing the effects of prolonged ketamine and sufentanil infusions found no difference in the mean daily intracranial pressure and cerebral perfusion pressure of patients, all of whom had sustained traumatic brain injury. (boldcityem.com)
  • CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil. (cdc.gov)
  • Sufentanil is a rapid onset opioid which typically doesn't get used as it peaks fast and is then metabolized by the liver very fast, making administering the drug very burdensome, even though it is highly efficacious and much safer than other opioids (multiple studies over time showing less oxygen desaturation, the most severe adverse event for opioids). (valueinvestorsclub.com)
  • Nasdaq: DRRX), an emerging specialty pharmaceuticals systems company, today announced the completion of dosing of the Phase I pharmacokinetic study for DURECT's TRANSDUR(TM)-based sufentanil patch. (durect.com)
  • Today, we are pleased to announce the completion of dosing of the Phase I pharmacokinetic study for our TRANSDUR sufentanil patch. (durect.com)
  • DURECT's TRANSDUR-based transdermal sufentanil product is intended to provide extended chronic pain relief for up to seven days, as compared to the three days of relief provided with currently available opioid patches. (durect.com)
  • This study examined intradermally injected sufentanil (S), a highly lipid soluble opioid, administered with and without lidocaine (L), in a thermal pain model. (elsevier.com)
  • Cite this: Sufentanil Hybrid Receives CHMP Nod for Post-Op Pain - Medscape - Jul 24, 2015. (medscape.com)
  • The opioid is a reformulated version of the long standing generic, Sufentanil, allowing it to be taken sublingually (ie under the tongue). (valueinvestorsclub.com)
  • In addition, 30% patients experienced pruritus in the 3 µg/ml sufentanilgroup compared with 10% and 5%, respectively, in the 2 µg/ml and 1 µg/ml sufentanil groups. (bvsalud.org)
  • Studies of the neurotoxicity of intrathecal sufentanil are controversial [5-7] but suggest that a direct effect cannot be excluded. (asahq.org)
  • bremelanotide will decrease the level or effect of sufentanil by Other (see comment). (medscape.com)