AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
SuccinylcholineNeuromuscular Depolarizing AgentsNeuromuscular Blocking AgentsNeuromuscular Nondepolarizing AgentsVecuronium BromideAndrostanolsFasciculationIntubation, IntratrachealPancuroniumNeuromuscular BlockadeCholinesterasesMalignant HyperthermiaThiopentalAnesthesia, IntratrachealAnesthesia, InhalationTubocurarineAnesthesia, GeneralUlnar NerveMasseter MusclePseudocholinesteraseMuscle RigidityApneaDecamethonium CompoundsAtracuriumgamma-CyclodextrinsHalothaneNitrous OxideButyrylcholinesterasePreanesthetic MedicationButyrylthiocholineNeuromuscular JunctionAnesthetics, IntravenousTachyphylaxisPropofolLaryngismusAnesthesiaMasticatory MusclesAnesthesia Recovery PeriodParabensLaryngeal MusclesFentanylPreservatives, PharmaceuticalDibucaineDiaphragmThiocholineLaryngoscopyAnesthesia, Intravenous
Succinylcholine
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
Neuromuscular Depolarizing Agents
Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.
Neuromuscular Blocking Agents
Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
Neuromuscular Nondepolarizing Agents
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Vecuronium Bromide
Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
Androstanols
Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.
Fasciculation
Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations can often by visualized and take the form of a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)
Intubation, Intratracheal
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Pancuronium
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.
Neuromuscular Blockade
The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
Cholinesterases
Malignant Hyperthermia
Rapid and excessive rise of temperature accompanied by muscular rigidity following general anesthesia.
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
Anesthesia, Intratracheal
Anesthesia, Inhalation
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Tubocurarine
A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.
Anesthesia, General
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Ulnar Nerve
A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.
Masseter Muscle
A masticatory muscle whose action is closing the jaws.
Pseudocholinesterase
An aspect of cholinesterases.
Muscle Rigidity
Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
Apnea
A transient absence of spontaneous respiration.
Decamethonium Compounds
Compounds that contain the decamethylenebis(trimethyl)ammonium radical. These compounds frequently act as neuromuscular depolarizing agents.
Atracurium
A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
gamma-Cyclodextrins
Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.
Halothane
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Nitrous Oxide
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
Butyrylcholinesterase
An aspect of cholinesterase (EC 3.1.1.8).
Preanesthetic Medication
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
Butyrylthiocholine
A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.
Neuromuscular Junction
The synapse between a neuron and a muscle.
Anesthetics, Intravenous
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Tachyphylaxis
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
Propofol
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Laryngismus
A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Masticatory Muscles
Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)
Anesthesia Recovery Period
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
Parabens
Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)
Laryngeal Muscles
The striated muscle groups which move the LARYNX as a whole or its parts, such as altering tension of the VOCAL CORDS, or size of the slit (RIMA GLOTTIDIS).
Fentanyl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Preservatives, Pharmaceutical
Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.
Dibucaine
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Diaphragm
The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.
Thiocholine
A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.
Laryngoscopy
Examination, therapy or surgery of the interior of the larynx performed with a specially designed endoscope.
Anesthesia, Intravenous
Process of administering an anesthetic through injection directly into the bloodstream.

Effects of an intubating dose of succinylcholine and rocuronium on the larynx and diaphragm: an electromyographic study in humans. (1/306)

BACKGROUND: Paralysis of the vocal cords is one objective of using relaxants to facilitate tracheal intubation. This study compares the neuromuscular blocking effect of succinylcholine and rocuronium on the larynx, the diaphragm, and the adductor pollicis muscle. METHODS: Electromyographic response was used to compare the neuromuscular blocking effect of succinylcholine and rocuronium on the laryngeal adductor muscles, the diaphragm, and the adductor pollicis muscle. Sixteen patients undergoing elective surgery were anesthetized with propofol and fentanyl, and their tracheas were intubated without neuromuscular blocking agents. The recurrent laryngeal and phrenic nerves were stimulated at the neck. The electromyographic response was recorded from electrodes placed on the endotracheal tube and intercostally before and after administration of 1 mg/kg succinylcholine or 0.6 mg/kg rocuronium. RESULTS: The maximum effect was greater at the adductor pollicis (100 and 99%) than at the larynx (96 and 97%) and the diaphragm (94 and 96%) after administration of succinylcholine and rocuronium, respectively (P < or = 0.05). Onset time was not different between the larynx (58+/-10 s), the diaphragm (57+/-8 s), and the adductor pollicis (54+/-13 s), after succinylcholine (all mean +/- SD). After rocuronium, onset time was 124+/-39 s at the larynx, 130+/-44 s at the diaphragm, and 115+/-21 s at the adductor pollicis. After succinylcholine administration, time to 90% recovery was 8.3+/-3.2, 7.2+/-3.5, and 9.1+/-3.0 min at the larynx, the diaphragm, and the adductor pollicis, respectively. Time to 90% recovery after rocuronium administration was 34.9+/-7.6, 30.4+/-4.2, and 49.1+/-11.4 min at the larynx, the diaphragm, and the adductor pollicis, respectively. CONCLUSION: Neuromuscular blocking effect of muscle relaxants on the larynx can be measured noninvasively by electromyography. Although the larynx appears to be resistant to muscle relaxants, we could not demonstrate that its onset time differed from that of peripheral muscles.  (+info)

Halothane induces calcium release from human skinned masseter muscle fibers. (2/306)

BACKGROUND: An increase in masseter muscle tone in response to halothane or succinylcholine anesthesia (or both) can be observed in healthy persons. Thus the authors compared the fiber-type halothane and succinylcholine sensitivities in human masseter and vastus lateralis muscles. METHODS: Masseter and vastus lateralis muscle segments were obtained from 13 and 9 healthy persons, respectively. After chemical skinning of a single fiber and loading the sarcoplasmic reticulum with Ca++ 0.16 microM solution, halothane (0.5-4 vol% bubbled in the incubating solution), succinylcholine (0.1 microM to 10 mM), or both sensitivities were defined as the concentration inducing more than 10% of the maximum tension obtained by application of 16 microM Ca++ solution. The myofilament response to Ca++ was studied with and without halothane by observing the isometric tension of skinned masseter fibers challenged with increasing concentrations of Ca++. Muscle fiber type was determined by the difference in strontium-induced tension measurements. RESULTS: A significant difference in halothane sensitivity was found between type 1 masseter fibers (0.6+/-0.2 vol%; mean +/- SD) versus type 1 (2.7+/-0.6 vol%) and type 2 vastus lateralis muscle (2.5+/-0.4 vol%). Succinylcholine did not induce Ca++ release by the sarcoplasmic reticulum. In the masseter muscle, 0.75 vol% halothane decreased the maximal activated tension by 40% but did not change the Ca++ concentration that yields 50% of the maximal tension. CONCLUSIONS: The very low halothane threshold for Ca++ release from the masseter muscle usually could be counteracted by a direct negative inotropic effect on contractile proteins. However, halothane may increase the sensitivity of the sarcoplasmic reticulum Ca++ release to succinylcholine-induced depolarization, leading to an increase in masseter muscle tone.  (+info)

Characteristics of recombinant human butyrylcholinesterase. (3/306)

AIM: To study the biochemical-pharmacological properties of the recombinant human butyrylcholinesterase (rhBChE) and thereby to size up the potential possibility of using it as a detoxifying agent in succinylcholine intoxication. METHODS: CHO-dhfr cells were transfected with plasmids by electroporation. BChE activity was determined colorimetrically by 5, 5'-dithiobis-(2-nitrobenzoic acid) (DTNB) method. Antigenicity was estimated by enzyme-linked immunosorbent assay and Western blot. RESULTS: The maximal expression amounted to 25.83 ng.h-1/10(6) cells. The rhBChE was highly similar to the native human BChE (nhBChE) in terms of its catalytic property, substrate affinity, inhibitor sensitivity, reactivation, stability, and immunoreactivity with anti-nhBChE antibodies. Mice challenged with 1.5 lethal dose of succinylcholine preincubated with rhBChE survived without any symptoms of intoxication. CONCLUSION: The rhBChE and nhBChE exhibit similar biochemical-pharmacological features. It is of potential value in practical use.  (+info)

Comparison of intubating conditions after rapacuronium (Org 9487) and succinylcholine following rapid sequence induction in adult patients. (4/306)

We have assessed intubating conditions provided by rapacuronium (Org 9487) and succinylcholine after rapid sequence induction of anaesthesia in adult patients undergoing elective surgery. We studied 335 patients, ASA I and II, in five centres. Two hundred and thirty-four subjects with normal body weight and 101 obese subjects were allocated randomly to one of four treatment groups differing in the neuromuscular blocking drug administered (rapacuronium 1.5 mg kg-1 or succinylcholine 1 mg kg-1) and in the technique used for induction of anaesthesia (fentanyl 2-3 micrograms kg-1 with thiopental 3-6 mg kg-1 or alfentanil 20 micrograms kg-1 with propofol 1.5-2 mg kg-1). Intubation was started at 50 s by an anaesthetist blinded to the drugs used. Intubating conditions were clinically acceptable (excellent or good) in 89.4% of patients after rapacuronium and in 97.4% after succinylcholine (P = 0.004), the estimated difference being 8.1% (95% confidence interval (CI) 2.0-14.1%). Neither anaesthetic technique nor subject group had an influence on intubating conditions. After intubation, the maximum increase in heart rate averaged 23.1 (SD 25.4%) and 9.4 (26.1%) after rapacuronium and succinylcholine, respectively (P < 0.001). Pulmonary side effects (bronchospasm and increased airway pressure) were observed in 10.7% (95% CI 5.8-17%) and 4.1% (95% CI 1.3-8.8%) of patients given rapacuronium and succinylcholine, respectively (P = 0.021). We conclude that after rapid sequence induction of anaesthesia in adults, clinically acceptable intubating conditions were achieved less frequently after rapacuronium 1.5 mg kg-1 than after succinylcholine.  (+info)

Hemodynamic and metabolic manifestations of acute endotoxin infusion in pigs with and without the malignant hyperthermia mutation. (5/306)

BACKGROUND: The hypermetabolic state induced by acute endotoxemia and malignant hyperthermia (MH) may be indistinguishable. The aims of this study were (1) to investigate the differences between MH and sepsis, (2) to determine whether acute endotoxemia can trigger MH, and (3) to establish the effects of dantrolene in these two disorders. METHODS: Three groups of swine were studied. All pigs were invasively monitored and initially anesthetized with nontriggering agents. A placebo MH-susceptible group (n = 5) received normal saline whereas the endotoxin groups (MH-susceptible, n = 6; MH-negative, n = 4) received intravenous endotoxin (250 microg/kg total) during 2.5 h. Halothane (1.5%) and succinylcholine (2-4 mg/kg) were then administered, followed by two doses of dantrolene (4 mg/kg total). RESULTS: Endotoxin infusion resulted in pulmonary hypertension and systemic hypotension in pigs with and without the MH mutation, but did not trigger MH. Halothane and succinylcholine triggered MH, evidenced by a markedly higher oxygen consumption in the MH-susceptible pigs that received endotoxin (325+/-196 ml/min) and those that did not (374+/-110 ml/min) compared to the MH-negative pigs (69+/-15 ml/min, P<0.0009), as well as muscular rigidity in the susceptible animals. Dantrolene reversed these changes. Three of the six MH-susceptible pigs that received endotoxin died; two died soon after triggering and one after dantrolene administration. In contrast, none of the MH-negative pigs or the MH-susceptible pigs that did not receive endotoxin died (0 of 9 vs. 3 of 6, P = 0.044). CONCLUSION: Endotoxemia does not trigger MH, but may worsen outcome if it occurs.  (+info)

Effect of rocuronium compared with succinylcholine on intraocular pressure during rapid sequence induction of anaesthesia. (6/306)

We have compared the effect of rocuronium and succinylcholine on intraocular pressure (IOP) during rapid sequence induction of anaesthesia using propofol and fentanyl, in a randomized double-blind study. We studied 30 adult patients, allocated to one of two groups. Anaesthesia was induced with fentanyl 2 micrograms kg-1 and propofol until loss of verbal response. This was followed by succinylcholine 1.5 mg kg-1 (group S; n = 15) or rocuronium 0.9 mg kg-1 (group R; n = 15). Laryngoscopy was performed 60 s later. IOP, mean arterial pressure (MAP) and heart rate (HR) were measured before induction, immediately before intubation and every minute after intubation for 5 min. A Keeler Pulsair air impulse tonometer was used to measure IOP and the mean of two readings obtained in the right eye at each measurement time was recorded. Intubating conditions were evaluated according to a simple scoring system. IOP in the succinylcholine group was significantly greater than that in the rocuronium group (mean 21.6 (SEM 1.4) mm Hg vs 13.3 (1.4) mm Hg; P < 0.001). Intubating conditions were equally good in both groups. We conclude that with rapid sequence induction of anaesthesia using propofol and fentanyl, rocuronium did not cause as great an increase in IOP as succinylcholine and may be an alternative in open eye injury cases.  (+info)

Intramuscular rapacuronium in infants and children: dose-ranging and tracheal intubating conditions. (7/306)

BACKGROUND: Intravenous rapacuronium's rapid onset and short duration suggest that intramuscular rapacuronium might facilitate tracheal intubation without prolonged paralysis. Accordingly, the authors injected rapacuronium into the deltoid muscle to determine the optimal dose and time for intubation in pediatric patients. METHODS: Unpremedicated patients (aged, 2 months to 3 yr) were studied. Part I: Spontaneous minute ventilation (V(E)) and twitch tension were measured during N2O/halothane anesthesia. Rapacuronium (2.2-5.5 mg/kg, given intramuscularly, n = 23), succinylcholine (4 mg/kg, given intramuscularly, n = 12), or vecuronium (0.1 mg/kg, given intravenously, n = 15) was given. Time to 50% depression of V(E) and 10% recovery of twitch were measured. Dose for each patient was changed 10-20% according to the previous patient's response. Part II: In 22 patients anesthetized with 0.82-1.0% halothane, the optimal rapacuronium dose determined in part I (infants, 2.8 mg/kg; children, 4.8 mg/kg) was given intramuscularly. Laryngoscopy was scored. Time to laryngoscopy was increased or decreased 0.5 min according to the previous patient's response. RESULTS: Part I: Rapacuronium typically depressed ventilation in < or = 2 min with 10% twitch recovery in 20-60 min. With succinylcholine, median time to ventilatory depression was 1.3 and 1.1 min for infants and children, respectively; for vecuronium, 0.7 and 0.6 min. Part I: Intubating conditions were good-excellent at 3.0 and 2.5 min in infants and children, respectively; time to 10% twitch recovery (mean +/- SD) was 31 +/- 14 and 36 +/- 14 min in the two groups. CONCLUSIONS: This pilot study indicates that deltoid injection of rapacuronium, 2.8 mg/kg in infants and 4.8 mg/kg in children, permits tracheal intubation within 2.5-3.0 min, despite a light plane of anesthesia. Duration of action is intermediate.  (+info)

Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol. (8/306)

BACKGROUND: Currently, the only approved muscle relaxant with a rapid onset and short duration of action is succinylcholine, a drug with some undesirable effects. Rapacuronium is an investigational nondepolarizing relaxant that also has a rapid onset and short duration and consequently should be compared with succinylcholine in its ability to facilitate rapid tracheal intubation. METHODS: This prospective, randomized clinical trial involved 336 patients. Anesthesia was induced with fentanyl and propofol and either 1.5 mg/kg rapacuronium or 1.0 mg/kg succinylcholine. The goal was to accomplish tracheal intubation by 60 s after administration of the neuromuscular blocking drug. Endotracheal intubation was performed, and conditions were graded by a blinded investigator. Recovery of neuromuscular function was assessed by electromyography. RESULTS: Intubation conditions were evaluated in 236 patients. Intubation by 60 s after drug administration occurred in 100% of patients with rapacuronium and in 98% with succinylcholine. Intubation conditions were excellent or good in 87% of patients with rapacuronium and in 95% with succinylcholine (P < 0.05). The time (median and range) to the first recovery of the train-of-four response was 8.0 (2.8-20.0) min with rapacuronium and 5.7 (1.8-17.7) min with succinylcholine (P < 0.05). The overall incidence of adverse effects was similar with both drugs. CONCLUSIONS: A 1.5-mg/kg dose of rapacuronium effectively facilitates rapid tracheal intubation. It can be considered a valid alternative to 1.0 mg/kg succinylcholine for this purpose.  (+info)

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SUCCINYLCHOLINE CHLORIDE Savings, Coupons and Information. | Succinylcholine (SUK seh nil KOH leen) is a skeletal muscle relaxant. It is used to relax muscles during surgery or while on a breathing machine.
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PharMEDium Services Issues Voluntary Nationwide Recall of Specific Lots of Potassium Phosphate and Succinylcholine Chloride Due...PharMEDium Services Issues Voluntary Nationwide Recall of Specific Lots of Potassium Phosphate and Succinylcholine Chloride Due...
For Immediate Release. June 26, 2017. Contact. Consumers. PharMEDium Services, LLC. Stephanie Hasan, Quality Manager, Clinical Pharmacist. 847-457-2220, [email protected] Media. Andrew Harrison, Acting Vice President of Quality Assurance, Regulatory Affairs & R&D 847-457-2271 [email protected] Announcement. PharMEDium Services is conducting a limited, voluntary recall due to Hospira Inc.s (Hospira) June 15, 2017 recall announcement that microbial growth was detected during a routine simulation of the manufacturing process and therefore there was a lack of sterility assurance. The products being recalled by PharMEDium Services were compounded using certain Hospira products. The recalled products are specific lots of Potassium Phosphate and Succinylcholine Chloride. This is a secondary recall based on a Hospiras recent recall: https://www.fda.gov/Safety/Recalls/ucm563383.htm. Per Hospira, in the event that impacted product is administered to a patient, there is a reasonable ...
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Succinylcholine Induced Hyperkalemia In Acquired Hypothyroidism | ZOS Life
Anesthesiology ; -8. Redrawn from Yanez and Martyn 26 ; used with permission. Jeevendra Martyn, M. A Jeevendra Martyn, Martina Richtsfeld. Goonetilleke A, Harris J: Clostridial neurotoxins.. Succinylcholine-induced Hyperkalemia J A. Awesome post, Mike. Shortly after the motor nerve axon grows into the developing muscle, these axons bring nerve-derived signals i. Succinylcholine has proven to be one of the best paralytic agents succinylcholine induced hyperkalemia in acquired hypothyroidism for rapid sequence intubation. Therefore, it seems prudent to avoid succinylcholine in patients who have recovered recently from critical illness, particularly if muscle function is still abnormal. The risk of hyperkalemia appears to peak days after the injury, but the exact time of onset and the duration of the risk period vary. A recent study noted patient that had been in the ICU for 16 days are at increased risk 6.. ALSO READ: Kharrazian Hypothyroidism In Dogs. Perinatal Urology. Aldosterone increases the ...
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Camber Pharma Launches Generic Quelicin® - Camber Pharmaceuticals
Piscataway, NJ, April 6, 2021- Camber Pharmaceuticals is pleased to announce that it has launched Succinylcholine Chloride Injection, which is the generic version of Quelicin®. Succinylcholine Chloride Injection is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.. Succinylcholine Chloride Injection is available from Camber in 200mg/10mL (20mg/mL) - 25x 10mL Vials.. Camber Pharmaceuticals is a fully integrated international pharmaceutical company that maintains quality and integrity in all its products. Its parent company, Hetero Drugs of Hyderabad India, is one of the worlds leading API and finished dosage manufacturers. Cambers commitment to the consumer is to bring the highest quality generic pharmaceuticals to the market to improve quality of life through cost-effective medications.. # # #. If you would like more information about this topic, please contact Megan Little at ...
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The Right Dose of Succinylcholine | Anesthesiology | ASA PublicationsThe Right Dose of Succinylcholine | Anesthesiology | ASA Publications
Careful inspection of the data suggests that although this is true, on average, not all patients are average. Functional residual capacity may be reduced and/or oxygen consumption increased and/or preoxygenation not optimal. 1 Also, succinylcholine does not have the same effect in all subjects, even if their plasma cholinesterase activity is within the normal range. Kopman et al. 3 found a 5-min range for all levels of recovery. In Hayes et al. s study, 8 manual ventilation had to be applied in 11% of cases to prevent hypoxia, and in Heier et al. s study, 7 one subject was apneic for 9 min! The safety of succinylcholine is limited by these relatively sensitive patients, and interestingly, a decrease in dose does not have a marked effect on the upper range of duration (10, 10.5, and 11 min in Kopman et al. s study 3 for 0.4, 0.6, and 1 mg/kg, respectively). This is not unexpected, because the half-life of succinylcholine is less than 1 min. 10 Doubling the dose of any drug should prolong its ...
https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1942749&resultClick=1
Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant; a...Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant; a...
TY - JOUR. T1 - Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant; a comparison with succinylcholine. AU - Wierda, JMKH. AU - van den Broek, L. AU - Proost, JH. AU - Verbaan, BW. AU - Hennis, PJ. PY - 1993/9. Y1 - 1993/9. N2 - In a randomized study, we evaluated lag time (time from the end of injection of muscle relaxant until the first depression of the train-of-four response [TOF]), onset time (time from the end of injection of muscle relaxant until the maximum depression of the first twitch of the TOF [T1]), neuromuscular block, and endotracheal intubating conditions at 1 min after 1 mg/kg succinylcholine (n = 15) and 1.5 mg/kg Org 9487 (n = 30). Two minutes after administration of Org 9487, 15 of the 30 patients received neostigmine for reversal. Recovery of neuromuscular block after succinylcholine, Org 9487 without and Org 9487 with neostigmine were compared using the time until T1 was 90% for the succinylcholine group, ...
https://research.rug.nl/en/publications/time-course-of-action-and-endotracheal-intubating-conditions-of-o
Quelicin® Succinylcholine Chloride - Injection, 20 mg/ml Strength, 10 ml, 25/Pkg, NDC 00409662902 - Quelicin® Succinylcholine...Quelicin® Succinylcholine Chloride - Injection, 20 mg/ml Strength, 10 ml, 25/Pkg, NDC 00409662902 - Quelicin® Succinylcholine...
Attention: Either you have JavaScript disabled or your browser does not support JavaScript. To work properly, this site requires that you enable JavaScript.. ...
https://www.pattersondental.com/Supplies/ItemDetail/070437624
Prolonged Apnea Following Succinylcholine Administration in Cancer Patients Receiving AB-132 | Anesthesiology | ASA PublicationsProlonged Apnea Following Succinylcholine Administration in Cancer Patients Receiving AB-132 | Anesthesiology | ASA Publications
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1967905
Room Temperature Stability of Injectable Succinylcholine DichlorideRoom Temperature Stability of Injectable Succinylcholine Dichloride
Author: Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T, Forest Jean-Marc, Hildgen Patrice, Year: 2008, Abstract: The purpose of this study was to determine the room temperature stability over a period of several months of commercially available intravenous succinylcholine dichloride (Quelicin, 20 mg/mL) in vials. A previously validated electrospray tandem mass spectrometry method developed for the determination of succinylcholine dichloride in plasma was used. This method was based upon a stable isotope dilution assay using hexadeuterosuccinylcholine diiodide as the internal standard and was shown to be sp
https://ijpc.com/Abstracts/Abstract.cfm?ABS=2721
Phase II depolarizing blockadePhase II depolarizing blockade
Background. Succinylcholine is comprised of two acetylcholine molecules joined together and acts as a depolarizing neuromuscular blocker by binding acetylcholine receptors at the post-synaptic neuromuscular junction end plate. The resultant end plate depolarization initially stimulates muscle contraction; however, because succinylcholine is not degraded by acetylcholinesterase, it remains in the neuromuscular junction to cause continuous end plate depolarization and subsequent muscle relaxation. This is termed a phase I block.. Mechanism of Phase II Block. With increasing doses of succinylcholine (i.e., a large single dose, repeated doses, or a continuous infusion), a phase II block may occur. Continuous activation of acetylcholine receptors leads to ongoing shifts of sodium into the cell and potassium out of the cell. Despite this, the post-junctional membrane potential eventually moves in the direction of normal even in the continued presence of succinylcholine. This is due to increased ...
http://www.openanesthesia.org/aba_phase_ii_depolarizing_blockade/
Injection Succinylcholine Supplier,Exporter,Wholesaler,Distributor,Manufacturer in IndiaInjection Succinylcholine Supplier,Exporter,Wholesaler,Distributor,Manufacturer in India
MEDWISE OVERSEAS PVT LTD - Manufacturer & Supplier,Exporter Of Injection Succinylcholine,Gujarat, India. Find More Detail For Injection Succinylcholine Manufacturers & Suppliers,Exporter From Gujarat, India
https://www.medwiseoverseas.in/injection-succinyl-choline-3693693.html
HPLC Method Development and Validation for Preservative Content (Methyl Paraben) For Succinylcholine Chloride InjectionHPLC Method Development and Validation for Preservative Content (Methyl Paraben) For Succinylcholine Chloride Injection
International Journal of Pharmacy and Pharmaceutical Research (IJPPR) will give best paper award every year in the form of money along with certificate to support research activity of scholar ...
http://ijppr.humanjournals.com/14-2/
Celocurin (Succinylcholine Chloride) Ipex MedicalCelocurin (Succinylcholine Chloride) Ipex Medical
Celocurin information about active ingredients, pharmaceutical forms and doses by Ipex Medical, Celocurin indications, usages and related health products lists
http://drugs-about.com/drugs-c/celocurin.html
Suxalin (Succinylcholine Chloride) Celon LaboratoriesSuxalin (Succinylcholine Chloride) Celon Laboratories
Suxalin information about active ingredients, pharmaceutical forms and doses by Celon Laboratories, Suxalin indications, usages and related health products lists
http://drugs-about.com/drugs-s/suxalin.html
succinylcholine - Everything2.comsuccinylcholine - Everything2.com
Marketed as Suxamethonium, succinylcholine is a depolarizing muscle relaxant, first used in 1951 as a muscle relaxant. It is still used today for rapid ...
https://everything2.com/title/succinylcholine
Muscle Electromechanical Correlations during Succinylcholine InfusionMuscle Electromechanical Correlations during Succinylcholine Infusion
The study was designed to compare the electromyographic (EMG) and evoked twitch tension (TT) responses in humans to train-of-four stimulation during neuromuscular blockade induced with a continuous Succinylcholine infusion. Mean values of TT correlated well with EMG (r | 0.97), but several consisten...
https://insights.ovid.com/anesthesia-analgesia/asag/1984/10/000/muscle-electromechanical-correlations-during/3/00000539
Most recent papers with the keyword Succinylcholine | Read by QxMDMost recent papers with the keyword Succinylcholine | Read by QxMD
This third installment of the history of basic airway management discusses the transitional-progressive-years of anesthesia from 1904 to 1960. During these 56 yr, airway management was provided primarily by basic techniques with or without the use of a face mask. Airway maneuvers were inherited from the artisanal era: head extension and mandibular advancement. The most common maneuver was head extension, also used in bronchoscopy and laryngoscopy. Basic airway management success was essential for traditional inhalation anesthesia (ether, chloroform) and for the use of the new anesthetic agents (cyclopropane, halothane) and intravenous drugs (thiopental, curare, succinylcholine ...
https://www.readbyqxmd.com/keyword/65754
UCSF Depression Trial: ECT/Succinylcholine: Biochemical, Serum and Cardiovascular Changes
Patients will receive the anesthetic that is traditionally given which includes appropriate doses of succinylcholine. Serum potassium and creatinine phosphokinase (CK) levels will be determined pre and post anesthesia; serum and urine myoglobin will be determined post anesthesia. Vital signs data [i.e., heart rate (arrhythmias) and arterial blood pressure] will be compared pre and post anesthesia. In addition patients will be asked about the presence of muscle pain (myalgia) 1 hour before discharge from the recovery room and the following day post ECT.. ...
https://clinicaltrials.ucsf.edu/trial/NCT00750906
Prolonged Paralysis Associated with Succinylcholine -A Case Report<...Prolonged Paralysis Associated with Succinylcholine -A Case Report<...
TY - JOUR. T1 - Prolonged Paralysis Associated with Succinylcholine -A Case Report. AU - 清楷, 曾. PY - 2000. Y1 - 2000. M3 - 文章. VL - 38. JO - Asian Journal of Anesthesiology. JF - Asian Journal of Anesthesiology. SN - 2468-824X. IS - 4. ER - ...
https://scholar.lib.ntnu.edu.tw/en/publications/prolonged-paralysis-associated-with-succinylcholine-a-case-report
A870 SUCCINYLCHOLINE ACTIONS IN PLASMA FROM PATIENTS WITH AND WITHOUT BURNS | Anesthesiology | American Society of...A870 SUCCINYLCHOLINE ACTIONS IN PLASMA FROM PATIENTS WITH AND WITHOUT BURNS | Anesthesiology | American Society of...
R. J. Storella, J. Hill; A870 SUCCINYLCHOLINE ACTIONS IN PLASMA FROM PATIENTS WITH AND WITHOUT BURNS. Anesthesiology 1990; 73:NA doi: https://doi.org/10.1097/00000542-199009001-00868. Download citation file:. ...
https://pubs.asahq.org/anesthesiology/article/73/3A/NA/49574/A870-SUCCINYLCHOLINE-ACTIONS-IN-PLASMA-FROM
Can I be allergic to Succinylcholine?Can I be allergic to Succinylcholine?
1 Answer - Posted in: succinylcholine, surgery - Answer: There is no need to worry unless you ever need surgery. In which case you ...
https://www.drugs.com/answers/can-i-be-allergic-to-succinylcholine-182997.html
SUCCINYLCHOLINE Medical Labels - Free ShippingSUCCINYLCHOLINE Medical Labels - Free Shipping
SUCCINYLCHOLINE Medical Labels are designed for optimum performance in any medical environment. These labels are recommended for surgical centers and hospitals. This medical label is made with aggressive permanent adhesive with a service temperature ranging from -65 to 220 Fahrenheit.
https://www.labelvalue.com/labels/printed-labels/medical-healthcare-labels/anesthesia-drug-labels/succinylcholine-medical-labels-p-1511.html
On some side effects of succinylcholine (listenone) during prolonged use]. - Semantic ScholarOn some side effects of succinylcholine (listenone) during prolonged use]. - Semantic Scholar
Semantic Scholar extracted view of [On some side effects of succinylcholine (listenone) during prolonged use]. by A. I. Briskin et al.
https://www.semanticscholar.org/paper/On-some-side-effects-of-succinylcholine-listenone-Briskin-Tsirul-nik/a419f2f8332465f3ab0f6d68a6ffe3569a5c8cb9
ANECTINE (Succinylcholine) dosage, indication, interactions, side effects | EMPR - ONAANECTINE (Succinylcholine) dosage, indication, interactions, side effects | EMPR - ONA
ANECTINE (Succinylcholine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
http://www.oncologynurseadvisor.com/anectine/drug/3993/
Pitchpull: Its Best to Be Nice!Pitchpull: Its Best to Be Nice!
And they know how to handle combative patients. There are wonderful medicines...... succinylcholine chloride........pavulon, that paralzye patients. When paralyzed, patients quit breathing for themselves and my crews have to breath for them manually. With succinylcholine, (sux), the patient is fully concious and aware they cant breathe. Crews using sux will normally administer a strong sedative so the patient goes to La La land.......the patient could care less who is in charge of the breathing! Life is wonderful ...
http://pitchpull.blogspot.com/2005/05/its-best-to-be-nice.html
Causes of upregualtions of NAChRCauses of upregualtions of NAChR
Upregulation of Acetylcholine receptors leads to increased sensitivity to Succinylcholine and risk for hyperkalemia due to depolarization of the muscle membrane. May occur in:. 1) Spinal Cord Injury. 2) Stroke. 3) Burns. • After immobilization, upregulation of NAChRs. • Avoid Succinylcholine - especially after 24 hours post burn and for up to 1-2 years post burn (may take months to years to return to preburn levels of NAChR). • Resistance to nondepolarizing NMBDs and increased sensitivity to succinylcholine. 4) Prolonged immobility. 5) Prolonged exposure to neuromuscular blockers. • Typically seen in ICUs to facilitate mechanical ventilation, tetanus, status epilepticus, reduction in oxygen consumption. 6) Multiple Sclerosis. • Demyelination of the CNS. • Attention autonomic dysfunction. 7) Guillain Barre syndrome. • Demyelination and axonal degeneration produce functional denervation of muscle and upregulation of NAchRs at the postsynaptic membrane. • Pay attention to autonomic ...
http://www.openanesthesia.org/causes_of_upregualtions_of_nachr/
Anesthesiology - Global Resources: Uganda - LibGuides at University of North Carolina Chapel Hill
Syndromes: When Being Unique is Scary (PDF, 1.2 MB). M. Concetta Lupa. Palliative Sedation (PDF, 464 KB). B. Craig Weldon. The Challenging Pediatric Airway (PDF, 2.6 MB). Ann Bailey, Amelia Drake. NPO Guidelines: What, How Much and Why (PDF, 372 KB). Janey Phelps. The Best Thing Since Sliced Bread: The LMA in Modern Pediatric Anesthesia (PDF, 1.5 MB). Wes Templeton. The Child with an Upper Respiratory Infection (PDF, 936 KB). John B. Eck. The Challenging Pediatric Cardiac Patient (PDF, 2.6 MB). Edmund Jooste. Succinylcholine: Succinylcholine has no place in pediatric anesthesia (PDF, 712 KB). Wads Ames. Succinylcholine: born 1951-and still going faster (PDF, 1.8 MB). Matthias W. Konig. The ABCs of Pediatric Resucitation (PDF, 2.3 MB). Benny Joyner. The Obstructive Sleep Apnea Patient for Tonsillectomy (PDF, 516 KB). Timothy E. Smith. The Combative Pediatric Patient (PDF, 1.5 MB). Sara Pittenger. ...
http://guides.lib.unc.edu/c.php?g=8480&p=43605
Notes: November 2011Notes: November 2011
Some of our waste is generated by single-dose vials. When I draw up succinylcholine, I draw up a 10cc syringe. Very few patients would require the full 10cc, and furthermore, there are few situations in which you dose succinylcholine twice due to risk of bradycardia and asystole. So for any patient who gets succinylcholine, some amount is wasted. Although I could calculate how much each patient would need and draw up a syringe with just the right amount, the vials are supposed to be single-dose; sterility is not guaranteed if I use a vial for multiple syringes. So like every other anesthesiologist, I draw up the full dose even though I never intend to give it all. This costs the system not only the additional drug, but also the biochemical disposal of the extra medication and the financial costs. This boggles my mind; why havent we figured out a way to reduce this? And the topic raises other concerns; should patients be charged for the amount of medication they receive (such as 5cc of ...
http://asclepion.blogspot.com/2011/11/
QUELICIN® How Supplied/Storage and Handling (succinylcholine chloride injection, USP) | Pfizer Medical Information - AustraliaQUELICIN® How Supplied/Storage and Handling (succinylcholine chloride injection, USP) | Pfizer Medical Information - Australia
Refrigeration of the undiluted agent will assure full potency until expiration date. All units carry a date of expiration.. Store in refrigerator 2° to 8°C (36° to 46°F). The multi-dose vials are stable for up to 14 days at room temperature without significant loss of potency.. ...
https://www.pfizermedicalinformation.com.au/en-us/quelicin/storage-handling
pharmacy
By David Showalter, PharmD, System Director, Pharmacy Services S: On 06/15/17, Pfizer/Hospira issued a voluntary recall for 3 medications: Sodium bicarbonate vials, Succinylcholine Chloride vials, Potassium Phosphates vials. B: The FDA communicated a voluntary recall from Pfizer/Hospira after … Continue reading →. ...
https://blog.mainlinehealth.org/mlh-clinician/tag/pharmacy/
Hospira sterility concerns prompt PharMEDium recall | Righting Injustice
Hospira Inc.s recall of injectable drugs has spurred PharMEDium Services to recall potassium phosphate and succinylcholine chloride.
http://www.rightinginjustice.com/news/2017/06/30/hospira-sterility-concerns-prompt-pharmedium-recall/
Posts by Jamie RobinsonPosts by Jamie Robinson
by Jamie Robinson , Jun 28, 2019 , News. June 24, 2019 Amring Pharmaceuticals Inc. (Amring), a generic pharmaceutical and ophthalmic medical device company, announced today that it has launched two valued drugs into its generic portfolio and to the U.S. Market: Succinylcholine Chloride Injection, a generic ...
https://www.amringusa.com/author/jamie/
Pharmacogenetic testing for Suxamethonium (Succinylcholine) - Genomics and other omics tools for enabling Medical Decisions ...Pharmacogenetic testing for Suxamethonium (Succinylcholine) - Genomics and other omics tools for enabling Medical Decisions ...
The GOMED programme aims to provide a platform for clinicians to tap into the rich and varied expertise of CSIR-IGIB in disease genomics to solve clinical problems. The Institute brings to table its pioneering expertise in genomics in the country, demonstrated over almost a decade through the Indian Genome variation project, the sequencing of first Indian personal genome and ongoing clinical genomics efforts in rare and common diseases with a large number of public and private healthcare institutions in the country.
http://gomed.igib.in/scoline
Alexis Pelletier-Bui, MD | EM DailyAlexis Pelletier-Bui, MD | EM Daily
Airway cart to 9A. Intern, this tube is yours. What meds do you want?. After the initial self-pulse check and change of scrub pants, two words come to mind: SOAP ME. Not in the literal sense, which may or may not be necessary depending on how nervous one is, but in the handy-dandy-easy-to-remember-in-high-pressure-situations-mnemonic sense. The deer-in-headlights (AKA intern-in-headlights look aside), this edition aims to take a look into an expected adverse reaction with a commonly used rapid sequence intubation (RSI) medication: hyperkalemia associated with succinylcholine administration.. ...
http://emdaily.cooperhealth.org/authors/alexis-pelletier-bui-md?page=1
Nurse Nacole ◂ Nursing Resources: Nursing Tip of the Day! - Critical Care NursingNurse Nacole ◂ Nursing Resources: Nursing Tip of the Day! - Critical Care Nursing
When a patient has a contraindication to succinylcholine, rocuronium bromide is the paralytic agent of choice. At a dose of 1.0 - 1.2 mg/kg IV, rocuronium achieves intubating conditions similar to those of succinylcholine and lasts 50 minutes. ...
http://www.nursenacole.com/2017/12/nursing-tip-of-day-critical-care-nursing_17.html
Comparative evaluation of effect of…Comparative evaluation of effect of…
Methodology: Fifty patients of both sexes of ASA physical status I and II, between 15-50 years of age were selected for the study for one year. Patients with clinically significant pre-existing eye disease, raised base line IOP, cardiorespiratory illness, CNS diseases, difficult airway, obesity, those receiving any drug likely to have an effect on IOP and in whom use of succinylcholine was contraindicated were excluded. Patients were randomly assigned to two equal groups. Anesthesia was induced by propofol 2 mg/kg over 30 sec in all patients. In Group V patients we used vecuronium and in Group S used succinylcholine for intubation. Statistical analysis was done with one way ANOVA using SPSS software version 15.. Results: In Group V, 28.49% decrease in IOP after induction and one min after intubation IOP was increase to 14.53% but it remain still lower than the baseline value. In Group S, there was 28.14% increase in IOP after induction and one min after intubation IOP was increase to 35.56%. ...
http://www.apicareonline.com/comparative-evaluation-of-effect-of-vecuronium-and-succinylcholine-on-intraocular-pressure/
Detil Data SuccinylcholineDetil Data Succinylcholine
Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT ...
http://chem.izulthea.com/drugv.php?id=2274
Succinylcholine (By injection) | Lima Memorial Health SystemSuccinylcholine (By injection) | Lima Memorial Health System
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
http://www.limamemorial.org/health-library/Thomson%20DrugNotes/45/4819
Suxamethonium apnoea - Lab Tests Online AU
Suxamethonium apnoea occurs when a person has an extended paralysis of their airways following suxamethonium administration due to low levels of cholinesterase.
https://www.labtestsonline.org.au/learning/index-of-conditions/suxamethonium-apnoea
Phase II block | definition of phase II block by Medical dictionaryPhase II block | definition of phase II block by Medical dictionary
Looking for online definition of phase II block in the Medical Dictionary? phase II block explanation free. What is phase II block? Meaning of phase II block medical term. What does phase II block mean?
https://medical-dictionary.thefreedictionary.com/phase+II+block
Succinylcholine-Induced Hyperkalemia Complicating the Neuroleptic Malignant Syndrome | Annals of Internal Medicine | American...Succinylcholine-Induced Hyperkalemia Complicating the Neuroleptic Malignant Syndrome | Annals of Internal Medicine | American...
To the editor: Severe hyperkalemia may complicate the use of succinylcholine in patients with major burns, direct muscle trauma, and various neuromuscular disorders (1-3). Nontraumatic rhabdomyolysis is common in the neuroleptic malignant syndrome (4) but has not been recognized as a risk factor for succinylcholine-induced hyperkalemia. We present the case of a patient with the neuroleptic malignant syndrome complicated by massive rhabdomyolysis in whom life-threatening hyperkalemia developed after the administration of intravenous succinylcholine.. A 28-year-old white man was admitted for treatment of chronic back pain complicated by habitual narcotic and diazepam use. He had received succinylcholine during lumbar laminectomy three ...
http://annals.org/aim/article-abstract/701604/succinylcholine-induced-hyperkalemia-complicating-neuroleptic-malignant-syndrome
Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and...
TY - JOUR. T1 - Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and myalgia. T2 - A comparison with placebo. AU - Joshi, Girish P.. AU - Hailey, Amaha. AU - Cross, Steven. AU - Thompson-Bell, Gwendell. AU - Whitten, Charles C.. PY - 1999/12. Y1 - 1999/12. N2 - Study Objective: To evaluate the efficacy of cisatracurium, rocuronium, and d-tubocurarine in preventing succinylcholine-induced fasciculations and postoperative myalgia in patients undergoing ambulatory surgery. Design: Randomized, prospective, placebo-controlled trialSetting: Teaching hospital. Subjects: 80 ASA physical status I and II patients scheduled for elective ambulatory surgery with general anesthesia.Intervention: A standardized balanced anesthetic technique was used for all patients. Measurements and Main Results: Patients were randomized to receive cisatracurium 0.01 mg/kg, rocuronium 0.06 mg/kg, d-tubocurarine 0.05 mg/kg, or saline, 3 minutes prior to ...
https://utsouthwestern.pure.elsevier.com/en/publications/effects-of-pretreatment-with-cisatracurium-rocuronium-and-d-tuboc
Weight: Succinylcholine requirement and pseudocholinesterase activity?<...
TY - JOUR. T1 - Weight. T2 - Succinylcholine requirement and pseudocholinesterase activity?. AU - Bentley, J. B.. AU - Borel, J. D.. AU - Vaughan, R. W.. AU - Gandolfi, A. J.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=0019790277&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019790277&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019790277. VL - 55. SP - A213. JO - Anesthesiology. JF - Anesthesiology. SN - 0003-3022. IS - 3 Suppl.. ER - ...
https://arizona.pure.elsevier.com/en/publications/weight-succinylcholine-requirement-and-pseudocholinesterase-activ
Succinylcholine Use and Dantrolene Availability: Comment<...
TY - JOUR. T1 - Succinylcholine Use and Dantrolene Availability. T2 - Comment. AU - Joshi, Girish P.. AU - Desai, Meena. AU - Valedon, Arnaldo. AU - Gayer, Steven. PY - 2019/10/1. Y1 - 2019/10/1. UR - http://www.scopus.com/inward/record.url?scp=85072791617&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85072791617&partnerID=8YFLogxK. U2 - 10.1097/ALN.0000000000002949. DO - 10.1097/ALN.0000000000002949. M3 - Letter. C2 - 31453814. AN - SCOPUS:85072791617. VL - 131. JO - Anesthesiology. JF - Anesthesiology. SN - 0003-3022. IS - 4. ER - ...
https://miami.pure.elsevier.com/en/publications/succinylcholine-use-and-dantrolene-availability-comment
Spinal Cord Trauma - why would a patient use succinylcholine?Spinal Cord Trauma - why would a patient use succinylcholine?
1 Answer - Posted in: succinylcholine, spinal cord trauma, surgery - Answer: Ive done some research but have not been able to find any answers. ...
https://www.drugs.com/answers/spinal-cord-trauma-why-would-a-patient-use-135487.html
Resistance to Succinylcholine in Myasthenia Gravis | Anesthesiology | American Society of AnesthesiologistsResistance to Succinylcholine in Myasthenia Gravis | Anesthesiology | American Society of Anesthesiologists
JAMES B. EISENKRAFT, W. JEFFREY BOOK, STEPHEN M. MANN, ANGELOS E. PAPATESTAS, MICHAEL HUBBARD; Resistance to Succinylcholine in Myasthenia Gravis: A Dose-response Study. Anesthesiology 1988; 69:760-762 doi: https://doi.org/10.1097/00000542-198811000-00021. Download citation file:. ...
https://pubs.asahq.org/anesthesiology/article/69/5/760/685/Resistance-to-Succinylcholine-in-Myasthenia
Causes of hyperpyrexia - Things You Didnt KnowCauses of hyperpyrexia - Things You Didnt Know
Causes of hyperpyrexia - What is malignant hyperpyrexia? Anesthesia related. Malignant hyperpyrexia is another term for malignant hyperthermia. This disorder is caused mainly by gas anesthetics and depolarizing paralytics (eg succinylcholine) in patients with a genetic mutation (runs in families). When these patients are exposed, they may experience a sudden increase in cellular metabolism, potentially resulting in death if not caught early and treated aggressively.
https://www.healthtap.com/topics/causes-of-hyperpyrexia
Alizul: 10 TERRIFYING WAYS TO BECOME TRAPPED IN YOUR OWN BODYAlizul: 10 TERRIFYING WAYS TO BECOME TRAPPED IN YOUR OWN BODY
But exposure to succinylcholine and its terrifying effects has a sinister history. In the 1960s and 1970s, this drug was used as an experimental form of aversion therapy. In the 60s, patients in Atascadero State Hospital - a maximum security clinic for mentally ill and criminally insane males that is still open - were chosen for therapy if they exhibited acting out behaviors. Succinylcholine was administered with the goal of initiating paralysis...and a brief (one-minute) period of apnea (breathing cessation). Patients remained completely conscious but totally helpless as doctors lectured them about their behavioral issues. ...
https://alizul2.blogspot.com/2015/12/10-terrifying-ways-to-become-trapped-in.html
Indian Journal of Respiratory Care : Login
Tracheal intubation with rocuronium bromide using the timing principle - A comparison with succinylcholine for rapid sequence induction ...
http://www.ijrconline.org/citation.asp?issn=2277-9019
Article abstract | Medical Science MonitorArticle abstract | Medical Science Monitor
Background:The muscle-relaxing effects of succinylcholine are terminated via hydrolysis by plasma cholinesterase. There are multiple genetic variants of this enzyme and clinical circumstances that might influence the activity of plasma cholinesterase...
https://www.medscimonit.com/abstract/index/idArt/883530/act/2
Does Rapid Sequence Induction Have a Role in Pediatric Anesthesia?Does Rapid Sequence Induction Have a Role in Pediatric Anesthesia?
Michale Sofer Case Một cậu bé 5 tuổi vào cấp cứu vì gãy trên lồi củ xương cánh tay sau khi trèo lên cầu thang. Tiền sử bình thường. Cậu ngã sau ăn trưa khoảng 1
https://yho.vn/youre-wrong-im-right/does-rapid-sequence-induction-have-a-role-in-pediatric-anesthesia.html
Anesthesia Specifics for PPS | Post Polio: Polio PlaceAnesthesia Specifics for PPS | Post Polio: Polio Place
1. Post-polio patients are nearly always very sensitive to sedative meds, and emergence can be prolonged. This is probably due to central neuronal changes, especially in the Reticular Activating System, from the original disease.. 2. Non-depolarizing muscle relaxants cause a greater degree of block for a longer period of time in post-polio patients. The current recommendation is to start with half the usual dose of whatever youre using, adding more as needed. This is because the poliovirus actually lived at the neuromuscular junctions during the original disease, and there are extensive anatomic changes there, even in seemingly normal muscles, which make for greater sensitivity to relaxants. Also, many patients have a significant decrease in total muscle mass. Neuromuscular monitoring intraop helps prevent overdose of muscle relaxants. Overdose has been a frequent problem.. 3. Succinylcholine often causes severe, generalized muscle pain postop. Its useful if this can be avoided, if ...
http://www.polioplace.org/living-with-polio/anesthesia-specifics-pps
Things To Do To Shine on Your Anesthesia Clerkship, by Daniel Orlovich, MD, PharmD » in-Training, the online peer-reviewed...Things To Do To Shine on Your Anesthesia Clerkship, by Daniel Orlovich, MD, PharmD » in-Training, the online peer-reviewed...
While commonly used, these wont be readily accessible to you because they are controlled substances (read habit forming): morphine, fentanyl and midazolam. Take note of the things you use on a regular basis - they serve as the things to focus on during your readings at night. You could even quiz yourself: What are we using the zofran for? Which one is the miller and which is the mac blade? What are the indications for succinylcholine?. The less inefficiencies and fumbling around, the more time you can focus on the case and be taught by the resident.. 3. Come Prepared. I personally thought the Stanford CA Tutorial was easy to read and packed with high-yield material. Pick out a chapter or two a day and discuss them with your resident.. In terms of what to carry in the operating room, I liked Pocket Anesthesia as a reference guide as well as Dukes Anesthesia Secrets to anticipate the pimp questions and get a more general overview of the cases.. Before you leave for the day, ask for the ...
https://in-training.org/things-shine-anesthesia-clerkship-daniel-orlovich-m-d-pharmd-11604
Journal of Clinical and Basic Cardiology - Instructions for Authors
Methods section. For animals used in experiments, state the species, strain, number used, and other pertinent descriptive characteristics. For human subjects or patients, describe their characteristics. When describing surgical procedures on animals, identify the preanesthetic and anesthetic agents used and state the amount or concentration and the route and frequency of administration for each. The use of paralytic agents, such as curare or succinylcholine, is not an acceptable substitute for anesthetics. For other invasive procedures on animals, report the analgesic or tranquillising drugs used. If none were used, provide justification for such exclusion. Generic names of drugs must be given. Manuscripts that describe studies on humans must indicate that the study was approved by an institutional review committee and that the subjects gave informed consent. Reports of studies on both an imals and humans must indicate that the procedures followed were in accordance with institutional guidelines ...
https://www.kup.at/journals/jcbc/instructions.html
The Tale of the Gasping BabyThe Tale of the Gasping Baby
As we all do, I went through my mental rolodex of solutions. I thought about using sedation - such as Ketamine or Versed - or using a paralytic, such as Succinylcholine. However, since the airway - although partially compromised - was at least functioning well enough, I decided against all these as I didnt want to make things worse.. Being the cautious person I am, I called for an anesthesiologist to come to the bedside. If things went well, I wouldnt need him, but if they didnt, we could both plead our cases to the jury.. Now the breath holding started...ours, that is.. When everything seemed ready and after saying a quick prayer under my breath, I had one nurse hold the childs body down and another hold the head. We did this without the comfort of sedation, so I wanted things to go seamlessly.. Using a laryngoscope with a mac blade, I put the blade in on the right side of the mouth and swept the tongue left. A glint of gold appeared, but disappeared as the child moved her tongue, and ...
https://www.boundtreeuniversity.com/products/monitoring-and-defibrillation/articles/740701-The-Tale-of-the-Gasping-Baby
BBC dedah cara Mahmoud dibunuhBBC dedah cara Mahmoud dibunuh
LONDON - Perbadanan Penyiaran British (BBC) menyiarkan dokumentari yang menceritakan bagaimana komplot agensi perisikan Israel, Mossad membunuh pengasas sayap bersenjata Hamas, Mahmoud al-Mabhouh, lapor sebuah akhbar kelmarin.. Dokumentari bertajuk Passports To Kill yang disiarkan kelmarin menyatakan bahawa Mahmoud diburu Mossad kerana membuat pengakuan terbuka kepada media bahawa dia berasa puas kerana dapat membunuh askar Yahudi selain menjadi orang tengah dalam penyeludupan roket dari Iran ke Gaza.. Mayatnya ditemui pada 19 Januari lalu, 16 jam selepas dia dibunuh di bilik 203, Hotel Al Bustan Rotana, Emiriyah Arab Bersatu (UAE).. Setelah identiti dan kedudukan Mahmoud dikenal pasti, empat daripada lebih 20 anggota skuad Mossad itu tiba di Dubai bagi melakukan misi membunuh itu, menangkap dan menyuntik kaki mangsa dengan racun succinylcholine untuk memberi kesan seolah-olah dia sesak nafas kerana diserang sakit jantung.. Namun, bimbang kehadiran mereka di bilik mangsa disedari, skuad pembunuh ...
http://kekoh.blogspot.com/2010/03/bbc-dedah-cara-mahmoud-dibunuh.html
Hexafluronium: Uses, Interactions, Mechanism of Action | DrugBank OnlineHexafluronium: Uses, Interactions, Mechanism of Action | DrugBank Online
Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block...
https://go.drugbank.com/drugs/DB00941
Anti-HMGA2 antibody (ab97276) | AbcamAnti-HMGA2 antibody (ab97276) | Abcam
Rabbit polyclonal HMGA2 antibody validated for WB, IP, IHC, ICC/IF and tested in Human. Referenced in 3 publications and 3 independent reviews. Immunogen…
http://www.abcam.com/hmga2-antibody-ab97276.html?productWallTab=Questions
Suxamethonium chlorideSuxamethonium chloride
"Succinylcholine, A Perfect Poison, Makes Appearance in the Dubai Killing , Medgadget". Compendium.ch: LYSTHENON 2% Inj Lös 100 ... "Succinylcholine Chloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. ... Tran DT, Newton EK, Mount VA, Lee JS, Wells GA, Perry JJ (October 2015). "Rocuronium versus succinylcholine for rapid sequence ... Instead in 1949 an Italian group led by Daniel Bovet was first to describe succinylcholine induced paralysis. The clinical ...
https://en.wikipedia.org/wiki/Suxamethonium_chloride
James Edward CottrellJames Edward Cottrell
Cottrell, JE; Hartung, JE; Giffin, JP; Shwiry, B (1983). "Intracranial and Hemodynamic Changes after Succinylcholine ... Cottrell, James E. (2018). "Succinylcholine and Intracranial Pressure". Anesthesiology. 129 (6): 1159-1162. doi:10.1097/ALN. ...
https://en.wikipedia.org/wiki/James_Edward_Cottrell
Neuromuscular-blocking drugNeuromuscular-blocking drug
Succinylcholine may also trigger malignant hyperthermia in rare cases in patients who may be susceptible. In depolarizing the ... An example is succinylcholine. Depolarizing blocking agents work by depolarizing the plasma membrane of the muscle fiber, ... Just like acetylcholine, succinylcholine, decamethonium and other polymethylene chains, of the appropriate length and with two ... Keeping the distance in mind the structure of the chain can vary (double bonded, cyclohexyl, benzyl, etc.) Succinylcholine has ...
https://en.wikipedia.org/wiki/Neuromuscular-blocking_drug
Atracurium besilateAtracurium besilate
It can also be used to help with endotracheal intubation but suxamethonium (succinylcholine) is generally preferred if this ... Bele-Binda N, Valeri F (Jan 1971). "A case of bronchospasm induced by succinylcholine". Canadian Anaesthetists' Society Journal ... Cardan E, Deacu E (Jan 1972). "Bronchospasm following succinyl choline". Anaesthesist. 21 (1): 27-29. PMID 4111555. Yeung ML, ... tubocurarine and succinylcholine, as well as alcuronium, pancuronium, vecuronium, and gallamine. Seizures rarely occur. Because ...
https://en.wikipedia.org/wiki/Atracurium_besilate
Lambert-Eaton myasthenic syndromeLambert-Eaton myasthenic syndrome
... prolonged apnoea after administration of succinylcholine". Lancet. 265 (6799): 1291-3. doi:10.1016/S0140-6736(53)91358-0. PMID ...
https://en.wikipedia.org/wiki/Lambert–Eaton_myasthenic_syndrome
FasciculationFasciculation
The depolarizing neuromuscular blocker succinylcholine causes fasciculations. It is a normal side effect of the drug's ... can be prevented with a small dose of a nondepolarizing neuromuscular blocker prior to the administration of succinylcholine, ...
https://en.wikipedia.org/wiki/Fasciculation
Postoperative residual curarizationPostoperative residual curarization
Succinylcholine is the only depolarizing NMBA available for clinical use. It produces a neuromuscular blockade that is the ... When a continuous infusion, repeated doses, or a large dose of succinylcholine (>4 mg/kg) is used, the risk of a Phase II block ... TOF fade is indicative of phase II block that is likely to occur in patients who received succinylcholine and may resemble ... Tran DT, Newton EK, Mount VA, Lee JS, Wells GA, Perry JJ (29 October 2015). "Rocuronium versus succinylcholine for rapid ...
https://en.wikipedia.org/wiki/Postoperative_residual_curarization
Rocuronium bromideRocuronium bromide
Tran, DT; Newton, EK; Mount, VA; Lee, JS; Wells, GA; Perry, JJ (29 October 2015). "Rocuronium versus succinylcholine for rapid ... like succinylcholine. It was designed to be a weaker antagonist at the neuromuscular junction than pancuronium; hence its ...
https://en.wikipedia.org/wiki/Rocuronium_bromide
Nicotinic antagonistNicotinic antagonist
Succinylcholine is a nicotinic agonist. See neuromuscular blocking agents page for details on the mechanism of action. ...
https://en.wikipedia.org/wiki/Nicotinic_antagonist
Wouter BassonWouter Basson
... succinylcholine, and tubocurarine. In 2021, the revelation that he was working at a Western Cape Mediclinic facility caused ...
https://en.wikipedia.org/wiki/Wouter_Basson
Neuromuscular blocking agentsNeuromuscular blocking agents
Succinylcholine interacts with nicotinic receptor to open the channel and cause depolarization of the end plate, which later ... Later, since succinylcholine is not able to be metabolised and removed effectively at the synapse, the depolarized membranes ... Use of succinylcholine infusion or repeated bolus administration increase the risk of Phase II block and prolonged paralysis. ... Options include succinylcholine, rocuronium or vecuronium if sugammadex is available for rapid reversal block. Any short or ...
https://en.wikipedia.org/wiki/Neuromuscular_blocking_agents
List of serial killers by countryList of serial killers by country
Death"; killed six people with succinylcholine in the town of Dhom. Raman Raghav: known as "Psycho Raman"; Mumbai man who ...
https://en.wikipedia.org/wiki/List_of_serial_killers_by_country
Gerhard WernerGerhard Werner
He was instrumental in introducing the neuropharmacological use of Succinylcholine. Werner became Chairman of the Pharmacology ...
https://en.wikipedia.org/wiki/Gerhard_Werner
Lethal injectionLethal injection
Other drugs in use are succinylcholine chloride and tubocurarine chloride. Pancuronium bromide is a derivative of the alkaloid ...
https://en.wikipedia.org/wiki/Lethal_injection
Rapid sequence inductionRapid sequence induction
Succinylcholine - This drug has rapid onset of action and fast duration. Its dosages are between 1 and 2 mg/kg body weight with ... Repetitive dosages of succinylcholine are discouraged to prevent vagal stimulation which leads to bradycardia. There are many ... Vecuronium is only used when there is a shortage of drugs such as succinylcholine and rocuronium. Sugammadex - It is used as a ... The patient is given a sedative and paralytic agent, usually midazolam / succinylcholine / Propofol and intubation is quickly ...
https://en.wikipedia.org/wiki/Rapid_sequence_induction
Meriter HospitalMeriter Hospital
"Succinylcholine in the Critically Ill Patient: When Is It Not OK+?" (Chapter 5). In: Canaday, Bruce Robert. ASHP's Clinical ...
https://en.wikipedia.org/wiki/Meriter_Hospital
The Teeth of the TigerThe Teeth of the Tiger
The succinylcholine is delivered through a hypodermic needle disguised as a pen. Twisting the nib switches the tip from a ... To carry out the assassinations, the brothers are issued a weapon utilizing succinylcholine, developed by a Columbia University ...
https://en.wikipedia.org/wiki/The_Teeth_of_the_Tiger
TrismusTrismus
Succinyl choline, phenothiazines and tricyclic antidepressants causes trismus as a secondary effect. Trismus can be seen as an ...
https://en.wikipedia.org/wiki/Trismus
Vecuronium bromideVecuronium bromide
It is also used to help with endotracheal intubation; however, suxamethonium (succinylcholine) is generally preferred if this ...
https://en.wikipedia.org/wiki/Vecuronium_bromide
Acetylcholinesterase inhibitorAcetylcholinesterase inhibitor
Anaesthesia: Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia. 5. ...
https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor
ClindamycinClindamycin
... may prolong the effects of neuromuscular-blocking drugs, such as succinylcholine and vecuronium. Its similarity to ...
https://en.wikipedia.org/wiki/Clindamycin
FlurothylFlurothyl
Premedication with pentothal and succinylcholine chloride, as is customary in ECT, was tested and found safe. Four random ...
https://en.wikipedia.org/wiki/Flurothyl
ParomomycinParomomycin
... may have dangerous reactions when used with the paralytic succinylcholine by increasing its neuromuscular effects. ...
https://en.wikipedia.org/wiki/Paromomycin
CholinesteraseCholinesterase
The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine. In ... a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine ...
https://en.wikipedia.org/wiki/Cholinesterase
Assassination of Mahmoud Al-MabhouhAssassination of Mahmoud Al-Mabhouh
Al-Mabhouh was injected in his leg with succinylcholine, a quick-acting, depolarizing paralytic muscle relaxant. It causes ...
https://en.wikipedia.org/wiki/Assassination_of_Mahmoud_Al-Mabhouh
List of Forensic Heroes IV charactersList of Forensic Heroes IV characters
He was Ng Yui-kwong's friend and was later injected with succinylcholine by him, causing him to die from suffocation. Lam King- ... He was Louis' friend and injected succinylcholine in his body to kill him due to financial disputes. Mak ling-ling as Principal ...
https://en.wikipedia.org/wiki/List_of_Forensic_Heroes_IV_characters
CyclophosphamideCyclophosphamide
... activity and may result in prolonged neuromuscular blockade when administered concurrently with succinylcholine. Tricyclic ...
https://en.wikipedia.org/wiki/Cyclophosphamide
Pseudocholinesterase deficiencyPseudocholinesterase deficiency
Drugs to avoid: Succinylcholine, also known as suxamethonium, which is commonly given to paralyse skeletal muscles as part of a ... In case of an atypical PCE or complete absence of PCE, the effect of the injected succinylcholine can last for up to 10 hours. ... Mivacurium, like succinylcholine, is a muscle relaxant and will have prolonged action in those with butyrylcholinesterase ... When succinylcholine is used for anesthesia, its high plasma concentration immediately after intravenous injection decreases ...
https://en.wikipedia.org/wiki/Pseudocholinesterase_deficiency
PralidoximePralidoxime
... succinylcholine, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with organophosphate poisoning. ...
https://en.wikipedia.org/wiki/Pralidoxime
HyperthermiaHyperthermia
... or the paralytic agent succinylcholine. Those who have this reaction, which is potentially fatal, have a genetic predisposition ...
https://en.wikipedia.org/wiki/Hyperthermia
Optimal Dose of Succinylcholine for Rapid Sequence InductionOptimal Dose of Succinylcholine for Rapid Sequence Induction
Succinylcholine remains one of the most commonly used neuromuscular blocking agents for rapid sequence induction, but its ... 7 with succinylcholine 0.3 mg kg− 1;. 2 with succinylcholine 0.4 mg kg− 1 ... Succinylcholine 1.5 mg kg− 1 does not produce more often excellent conditions compared with 1 mg kg− 1, while 2.0 mg kg− 1 does ... Conclusions: With succinylcholine regimens ≤0.5 mg kg− 1, excellent intubating conditions are less likely and apnoea times are ...
https://www.medscape.com/viewarticle/928030
ASA Update on Succinylcholine Shortages | American Society of Anesthesiologists (ASA)ASA Update on Succinylcholine Shortages | American Society of Anesthesiologists (ASA)
Succinylcholine Unfortunately, shortages of succinylcholine persist due to problems stemming from the supply and quality of raw ... In such instances, it is possible that procedures may need to be deferred until succinylcholine is available. As always, the ... Succinylcholine is a first line drug for emergency intubation, treatment of refractory laryngospasm and certain very brief ... ASA Update on Succinylcholine and Other Drug Shortages The American Society of Anesthesiologists is acutely aware of the ...
https://www.asahq.org/advocacy-and-asapac/fda-and-washington-alerts/washington-alerts/2011/02/asa-update-on-succinylcholine-and-other-drug-shortages
Coronavirus Treatment: Indoco Remedies Gets Usfda Approval For Succinylcholine Chloride InjectionCoronavirus Treatment: Indoco Remedies Gets Usfda Approval For Succinylcholine Chloride Injection
Indoco Remedies today said that it has got US FDA approval for its drug succinylcholine chloride (injection). This drug is the ... Coronavirus treatment: Indoco Remedies gets USFDA approval for succinylcholine chloride injection. Coronavirus treatment: ...
https://www.cnbctv18.com/healthcare/coronavirus-treatment-indoco-remedies-gets-usfda-approval-for-succinylcholine-chloride-injection-6002151.htm
Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene SyringesStability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes
Concentration levels of succinylcholine chloride injection were determined at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after ... The stability of 20-mg/mL succinylcholine chloride injection in 12-mL polypropylene syringes stored at ambient temperature and ... Succinylcholine Chloride 50-mg/mL Injection. Allen Loyd V Jr Jul/Aug 2013. 335. Buy. ... Room Temperature Stability of Injectable Succinylcholine Dichloride. Roy Julie J, Boismenu Daniel, Mamer Orval A, Nguyen Bao T ...
https://ijpc.com/Abstracts/Abstract.cfm?ABS=377
Succinylcholine induced masseter spasm during rapid sequence intubation may require a surgical airway: case report | Emergency...Succinylcholine induced masseter spasm during rapid sequence intubation may require a surgical airway: case report | Emergency...
succinylcholine. Succinylcholine has long been the neuromuscular blockade agent of choice for the emergency physician for rapid ... Succinylcholine is the neuromuscular blocking agent of choice in rapid sequence intubation due to its rapid onset of action and ... Succinylcholine: adverse effects and alternatives in emergency medicine. Am J Emerg Med1999;17:715-21. ... First and foremost, succinylcholine has many adverse effects that must be anticipated. Secondly, a patients external anatomy ...
https://emj.bmj.com/content/22/6/456
Succinylcholine and Intracranial Pressure | Anesthesiology | American Society of AnesthesiologistsSuccinylcholine and Intracranial Pressure | Anesthesiology | American Society of Anesthesiologists
Succinylcholine and Intracranial Pressure James E. Cottrell, M.D. James E. Cottrell, M.D. ... We decided to give an injection of succinylcholine to buy the small amount of time needed give one last dose of nifedipine. To ... Subsequent to our finding in cats, Lanier et al.22,23 found convincing evidence that succinylcholine induces sufficient muscle ... Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal ...
https://pubs.asahq.org/anesthesiology/article/129/6/1159/18274/Succinylcholine-and-Intracranial-Pressure
Local Anesthetic Toxicity Medication: Anticonvulsants, Barbiturates, Anxiolytics, Benzodiazepines, Neuromuscular Blockers,...Local Anesthetic Toxicity Medication: Anticonvulsants, Barbiturates, Anxiolytics, Benzodiazepines, Neuromuscular Blockers,...
Succinylcholine causes paralysis of airway and respiratory muscles; apnea ensues. Establishing and maintaining an airway and ...
https://emedicine.medscape.com/article/1844551-medication
An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy - Publications of the IAS...An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy - Publications of the IAS...
We recommend 1 mg/kg of succinylcholine dose be used in the first ECT session. For subsequent sessions, the dose may be altered ... The electroconvulsive therapy (ECT) guideline of the Royal College of Psychiatrists recommends a 0.5 mg/kg of succinylcholine ... Implications: The dose of muscle relaxant (succinylcholine) recommended in modified electroconvulsive therapy is not based on ... An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy ...
http://repository.ias.ac.in/119232/
Pseudocholinesterase deficiency: MedlinePlus GeneticsPseudocholinesterase deficiency: MedlinePlus Genetics
These fast-acting drugs, such as succinylcholine and mivacurium, are given to relax the muscles used for movement (skeletal ... Zelinski T, Coghlan G, Mauthe J, Triggs-Raine B. Molecular basis of succinylcholine sensitivity in a prairie Hutterite kindred ... Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population. Clin Chem. 2003 Aug;49(8): ... Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during ...
https://medlineplus.gov/genetics/condition/pseudocholinesterase-deficiency/
August 1966 - Volume 10 - Issue 4 : Survey of AnesthesiologyAugust 1966 - Volume 10 - Issue 4 : Survey of Anesthesiology
REAPPRAISAL OF INCIDENCE OF VENTRICULAR ARRHYTHMIAS FOLLOWING SUCCINYLCHOLINE ADMINISTRATION. AKDIKMEN, S. A.; BOBA, A.; ...
https://journals.lww.com/surveyanesthesiology/toc/1966/08000
20180607-429C30 Succinylcholine 20mg per mL in 5mL Room Temp-signed1 - New England Life Care20180607-429C30 Succinylcholine 20mg per mL in 5mL Room Temp-signed1 - New England Life Care
20180607-429C30_Succinylcholine_20mg_per_mL_in_5mL_Room_Temp-signed1. Posted June 27, 2018. by Certificate Manager ...
https://www.nelifecare.org/certificate/20180607-429c30_succinylcholine_20mg_per_ml_in_5ml_room_temp/20180607-429c30_succinylcholine_20mg_per_ml_in_5ml_room_temp-signed1/
Cabren, Cardioplen XL (felodipine) dosing, indications, interactions, adverse effects, and moreCabren, Cardioplen XL (felodipine) dosing, indications, interactions, adverse effects, and more
succinylcholine. Minor (1)felodipine increases effects of succinylcholine by pharmacodynamic synergism. Minor/Significance ... succinylcholine. felodipine increases effects of succinylcholine by pharmacodynamic synergism. Minor/Significance Unknown. Ca ...
https://reference.medscape.com/drug/cabren-cardioplen-xl-felodipine-342375
Genetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, EpidemiologyGenetics of Rubinstein-Taybi Syndrome: Practice Essentials, Pathophysiology, Epidemiology
Issues with perioperative management, including collapsible airway and susceptibility to succinylcholine, have also been ...
https://emedicine.medscape.com/article/948453-overview
VENTRICULAR FIBRILLATION IN HYPOTHERMIC DOGS AS INFLUENCED BY THIOPENTAL PENTOBARBITAL AND SUCCINYLCHOLINE | Anesthesiology |...
VENTRICULAR FIBRILLATION IN HYPOTHERMIC DOGS AS INFLUENCED BY THIOPENTAL PENTOBARBITAL AND SUCCINYLCHOLINE PHILIP A. RILEY, ... VENTRICULAR FIBRILLATION IN HYPOTHERMIC DOGS AS INFLUENCED BY THIOPENTAL PENTOBARBITAL AND SUCCINYLCHOLINE. Anesthesiology 1956 ...
https://asa2.silverchair.com/anesthesiology/article/17/2/277/19316/VENTRICULAR-FIBRILLATION-IN-HYPOTHERMIC-DOGS-AS
Dantrium, Ryanodex (dantrolene) dosing, indications, interactions, adverse effects, and moreDantrium, Ryanodex (dantrolene) dosing, indications, interactions, adverse effects, and more
... to reduce succinylcholine-induced fasciculations & post-op muscle pain, NMS ...
https://reference.medscape.com/drug/dantrium-ryanodex-dantrolene-343339
Simulated Succinylcholine Chloride- 20 mg/mL, 10 mL (10 vials/un [suxv] - $15.00 : PharmProps!, Medication Administration...
Sold in units of 10 vials PharmProps simulated succinylcholine chloride provides realistic training in a controlled ... but is labeled to simulate succinylcholine chloride. The marked concentration is 20 mg/mL. The vial contains 10 mL or 200 mg. ... Simulated Succinylcholine Chloride- 20 mg/mL, 10 mL (10 vials/un [suxv] - This vial contains only water, ... Simulated Succinylcholine Chloride- 20 mg/mL, 10 mL (10 vials/un. $15.00. This vial contains only water, but is labeled to ...
http://www.pharmprops.com/index.php?main_page=product_info&cPath=33&products_id=111
Ritedose Brings New Unit Dose Syringe Product to the Market: Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL) - The...Ritedose Brings New Unit Dose Syringe Product to the Market: Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL) - The...
Ritedose Brings New Unit Dose Syringe Product to the Market: Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL). May 14 ... With extended dating of 120 days, the single-dose syringe of Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL) can be ... This comes to market on the heels of a similar product from Ritedose - Succinylcholine Chloride Injection 200 mg/10 mL (20 mg/ ... Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL). It is part of a 12-product, six-month rollout from Ritedose for ...
https://ritedose.com/2021/05/14/ritedose-brings-new-unit-dose-syringe-product-to-the-market-succinylcholine-chloride-injection-100-mg-5-ml-20-mg-ml/
DailyMed - LITHIUM CARBONATE- lithium carbonate capsuleDailyMed - LITHIUM CARBONATE- lithium carbonate capsule
Symptoms are also more severe with faster-onset hyponatremia. Mild hyponatremia (i.e., serum Na , 120 mEq/L) can be asymptomatic. Below this threshold, clinical signs are usually present, consisting mainly of changes in mental status, such as altered personality, lethargy, and confusion. For more severe hyponatremia (serum Na , 115 mEq/L), stupor, neuromuscular hyperexcitability, hyperreflexia, seizures, coma, and death can result. During treatment of hyponatremia, serum sodium should not be elevated by more than 10 to 12 meq/L in 24 hours or 18 meq/L in 48 hours. In the case of severe hyponatremia where severe neurologic symptoms are present, a faster infusion rate to correct serum sodium concentration may be needed. Patients rapidly treated or with serum sodium ,120mEq/L are more at risk of developing osmotic demyelination syndrome (previously called central pontine myelinolysis). Occurrence is more common among patients with alcoholism, undernutrition, or other chronic debilitating illness. ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc6f07db-c9e6-4e2d-90f8-00868954594d
Our Pfizer Products Hold the Cure | PfizerOur Pfizer Products Hold the Cure | Pfizer
In this section find an overview of our Pfizer Products and search for information on our most popular Pfizer products. Our products are the results of 1500 scientists overseeing more than 500,000 lab tests and over 36 clinical trials before the first prescription. Our Pfizer products hold the cure.
https://www.pfizer.com/products?letter=V
Malignant Hyperthermia: What It Is, Symptoms & TreatmentMalignant Hyperthermia: What It Is, Symptoms & Treatment
Succinylcholine (fast-acting muscle relaxant).. Diagnosis and Tests How is malignant hyperthermia diagnosed?. If youre unaware ...
https://my.clevelandclinic.org/health/diseases/17945-malignant-hyperthermia
Emergency Pediatric Dosing 4 kilogramEmergency Pediatric Dosing 4 kilogram
Succinylcholine 8 mg. *Rocuronium 4 mg. *Vecuronium 0.4 mg. *Sedation Maintenance. *Lorazepam 0.2 mg ...
https://fpnotebook.com/ER/Pharm/EmrgncyPdtrcDsng4Klgrm.htm
Teva-Diltiazem CD - Uses, Side Effects, Interactions - MedBroadcast.comTeva-Diltiazem CD - Uses, Side Effects, Interactions - MedBroadcast.com
neuro-muscular blockers (e.g., muscle relaxants; atracurium, rocuronium, succinylcholine). * nitrates (e.g., isosorbide ...
https://www.medbroadcast.com/drug/getdrug/teva-diltiazem-cd
Malathion | Medical Management Guidelines | Toxic Substance Portal | ATSDR
The paralyzing effects of succinylcholine are likely to be prolonged because it will not be metabolized normally. ... use depolarizing neuromuscular blockers such as succinylcholine for rapid sequence intubation. ...
https://wwwn.cdc.gov/tsp/MMG/MMGDetails.aspx?mmgid=517&toxid=92
Frontiers | Risk Assessment of Electroconvulsive Therapy in Clinical Routine: A 3-Year Analysis of Life-Threatening Events in...Frontiers | Risk Assessment of Electroconvulsive Therapy in Clinical Routine: A 3-Year Analysis of Life-Threatening Events in...
The action of succinylcholine is short in onset and is used during a rapid induction of anesthesia, which at a dose of 1 mg/kg ... A total of 150 mg of propofol and 50 mg of succinylcholine were used for general anesthesia. ECT was applied unilaterally on ... Bryson, E. O., Kellner, C. H., Li, E. H., Aloysi, A. S., and Majeske, M. (2018). Extreme variability in succinylcholine dose ... Anesthesia was induced with propofol 1-1.5 mg/kg body weight and combined 282 with the muscle relaxant succinylcholine 0.7-1.0 ...
https://www.frontiersin.org/articles/10.3389/fpsyg.2021.767915/full
Acetazolamide for Injection (acetazolamide) dose, indications, adverse effects, interactions... from PDR.netAcetazolamide for Injection (acetazolamide) dose, indications, adverse effects, interactions... from PDR.net
Succinylcholine: (Moderate) Nondepolarizing neuromuscular blockers when combined with carbonic anhydrase inhibitors may lead to ...
https://pdr.net/drug-summary/Acetazolamide-for-Injection-acetazolamide-666.2521
Indication-specific dosing for Chinese club moss, Huperzine Rx-Brain, HUP, HUP A, Memorall, selagine (huperzine A), frequency...Indication-specific dosing for Chinese club moss, Huperzine Rx-Brain, HUP, HUP A, Memorall, selagine (huperzine A), frequency...
succinylcholine. Monitor Closely (1)huperzine A and succinylcholine both increase cholinergic effects/transmission. Use Caution ... succinylcholine. huperzine A and succinylcholine both increase cholinergic effects/transmission. Use Caution/Monitor. ...
https://reference.medscape.com/drug/chinese-club-moss-huperzine-rx-brain-huperzinea-344542
Internet Scientific Publications
Succinylcholine-induced hyperkalaemia in a patient with Parkinsons disease. Anesth Analg 1980; 59: 444-6. 10. Klausner JM, ... Neuromuscular blocking agents can be used safely however Succinylcholine has been reported to cause hyperkalaemia in a patient ...
http://ispub.com/IJA/13/2/8204
CDC | Toxic Syndrome Description: Nerve Agent and Organophosphate Pesticide PoisoningCDC | Toxic Syndrome Description: Nerve Agent and Organophosphate Pesticide Poisoning
ChlorideMasseter spasmNeuromuscular blockSpasmInjectionMuscle relaxantHalothaneIntubationRocuroniumRapid sequenceAirway managementDichlorideParalysisConcentrationAnesthesiaAbsenceDoseSyringesBlockadeInadequatePatientsMusclesSurgicalAdministrationDrugLevelsSummaryProduceExperienceConditionsProcedures
Chloride11
  • Succinylcholine Chloride Injection, USP is a sterile, nonpyrogenic solution to be used as an ultra short-acting, depolarizing, skeletal muscle relaxant See HOW SUPPLIED for summary of content and characteristics of the solutions. (nih.gov)
  • Succinylcholine Chloride, USP is chemically designated C 14 H 30 Cl 2 N 2 O 4 and its molecular weight is 361.31. (nih.gov)
  • Indoco Remedies today said that it has got US FDA approval for its drug succinylcholine chloride (injection). (cnbctv18.com)
  • The stability of 20-mg/mL succinylcholine chloride injection in 12-mL polypropylene syringes stored at ambient temperature and 4°C for up to 90 days was investigated. (ijpc.com)
  • Concentration levels of succinylcholine chloride injection were determined at 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes by means of a high-performance liquid chromatographic stability-indicating assay. (ijpc.com)
  • The loss in potency was less than 10% after 45 days of storage at 25°C and less than 1% after 90 days of storage at 4°C. The pH of succinylcholine chloride injection did not change appreciably during the 90-day study period. (ijpc.com)
  • This vial contains only water, but is labeled to simulate succinylcholine chloride. (pharmprops.com)
  • simulated succinylcholine chloride provides realistic training in a controlled environment. (pharmprops.com)
  • COLUMBIA, S.C. (May 14, 2021) - Ritedose, a 503B outsourcing facility located in South Carolina, just launched a new unit dose syringe product, Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL). (ritedose.com)
  • With extended dating of 120 days, the single-dose syringe of Succinylcholine Chloride Injection 100 mg/5 mL (20 mg/mL) can be stored at room temperature and is already diluted, labeled with cautionary statements, color-coded to ASTM drug class standards, and ready to be administered within OR and acute care settings. (ritedose.com)
  • This comes to market on the heels of a similar product from Ritedose - Succinylcholine Chloride Injection 200 mg/10 mL (20 mg/mL), released in March. (ritedose.com)
Masseter spasm2
  • 2- 5 In adults, succinylcholine can also produce transient masseter spasm that resolves when fasciculation stops. (bmj.com)
  • We present a case of succinylcholine induced masseter spasm in the emergency department requiring surgical cricothyroidotomy for airway control. (bmj.com)
Neuromuscular block1
  • The American Society of Anesthesiologists is acutely aware of the ongoing shortages of a number of anesthesia drugs, including the important neuromuscular blocking agent, succinylcholine. (asahq.org)
Spasm1
  • Succinylcholine Induced Masseter Muscle Spasm during Rapid Sequence Induction in a Pregnant Patient with Kypho- Scoliosis: Case Report. (aimdrjournal.com)
Injection1
  • Four minutes after succinylcholine injection, a severe bronchospasm was observed in the absence of any skin manifestation. (asahq.org)
Muscle relaxant4
  • Succinylcholine is a depolarizing skeletal muscle relaxant. (nih.gov)
  • Implications: The dose of muscle relaxant (succinylcholine) recommended in modified electroconvulsive therapy is not based on empirical research. (ias.ac.in)
  • Succinylcholine (fast-acting muscle relaxant). (clevelandclinic.org)
  • Succinylcholine (Sux) is a depolarizing skeletal muscle relaxant. (theprotectedairway.com)
Halothane1
  • one or more of the following drugs: halothane, isoflurane , sevoflurane, desflurane or succinylcholine. (nih.gov)
Intubation4
  • Succinylcholine is a first line drug for emergency intubation, treatment of refractory laryngospasm and certain very brief anesthetics requiring muscular paralysis such as electroconvulsive therapy. (asahq.org)
  • Succinylcholine has long been the neuromuscular blockade agent of choice for the emergency physician for rapid sequence intubation because of its rapid onset and relatively brief duration of action. (bmj.com)
  • Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. (unibas.ch)
  • Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. (unibas.ch)
Rocuronium2
  • So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. (unibas.ch)
  • Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI. (unibas.ch)
Rapid sequence1
  • The evidence base for the widely accepted standard regimen of succinylcholine for rapid sequence induction (1.0 mg kg − 1 ) remains unclear. (medscape.com)
Airway management1
  • The Society for Ambulatory Anesthesia (SAMBA) position statement for the use of succinylcholine for emergency airway management is presented. (sambahq.org)
Dichloride1
  • Succinylcholine is a diquaternary base consisting of the dichloride salt of the dicholine ester of succinic acid. (nih.gov)
Paralysis2
  • The paralysis following administration of succinylcholine is progressive, with differing sensitivities of different muscles. (nih.gov)
  • A small delay (mean = 55 s) occurred in time to recover from the respiratory paralysis with the 1 mg/kg dose of succinylcholine. (ias.ac.in)
Concentration1
  • Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. (nih.gov)
Anesthesia2
  • Anesthesia practices have recently had inadequate or limited supplies of succinylcholine. (asahq.org)
  • Subbakrishna, D K (1999) An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy Anesthesia and Analgesia, 89 (5). (ias.ac.in)
Absence2
  • In the absence of succinylcholine, anesthesiologists will need to exercise clinical judgment in determining which patients are particularly likely to require rapid onset, short duration muscle relaxation. (asahq.org)
  • This statement argues that, in the absence of succinylcholine, the morbidity and mortality from laryngospasm can be significant, indeed, higher than the unlikely scenario of succinylcholine- triggered malignant hyperthermia. (sambahq.org)
Dose3
  • Succinylcholine levels were reported to be below the detection limit of 2 µg/mL after 2.5 minutes of an IV bolus dose of 1 or 2 mg/kg in fourteen (14) anesthetized patients. (nih.gov)
  • The extent of motor seizure modification was rated on a five-point scale by two independent raters who were blinded to the succinylcholine dose. (ias.ac.in)
  • We recommend 1 mg/kg of succinylcholine dose be used in the first ECT session. (ias.ac.in)
Syringes1
  • Another report was received describing similar complaints with the labeling of neostigmine 1 mg/mL injectable syringes and succinylcholine 20 mg/mL injectable syringes compounded by KRS Global Biotechnology, Inc., located in Boca Raton, Florida. (fda.gov)
Blockade1
  • Garcia DF, Oliveira TG, Molfetta GA, Garcia LV, Ferreira CA, Marques AA, Silva WA Jr. Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine. (medlineplus.gov)
Inadequate1
  • Therefore, when a healthy appearing infant or child develops cardiac arrest soon after administration of succinylcholine, not felt to be due to inadequate ventilation, oxygenation or anesthetic overdose, immediate treatment for hyperkalemia should be instituted. (nih.gov)
Patients4
  • There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest and death after the administration of succinylcholine to apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular dystrophy. (nih.gov)
  • These results, when considered in conjunction with results previously obtained in humans, suggest that succinylcholine may be contraindicated in neurosurgical patients. (asahq.org)
  • Gatke MR, Bundgaard JR, Viby-Mogensen J. Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. (medlineplus.gov)
  • Patients with burns, crush injuries, and myopathies are at high risk of developing hyperkalemia, which is aggravated by the administration of succinylcholine. (medscape.com)
Muscles2
  • These fast-acting drugs, such as succinylcholine and mivacurium, are given to relax the muscles used for movement (skeletal muscles), including the muscles involved in breathing. (medlineplus.gov)
  • ECT results in direct stimulation of the masseter, temporalis, and pterygoid muscles which is not attenuated by administration of succinylcholine. (scirp.org)
Surgical1
  • Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. (bvsalud.org)
Administration1
  • Intracranial and Hemodynamic Changes after Succinylcholine Administration in Cats. (asahq.org)
Drug1
  • Unfortunately, shortages of succinylcholine persist due to problems stemming from the supply and quality of raw material needed to produce the product at Hospira, the largest manufacturer of the drug. (asahq.org)
Levels1
  • Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal conditions from control levels of 8 +/- 1 mmHg to 16 +/- 3 mmHg (+/- SEM, P less than 0.01), and in the presence of artificially increased ICP from control levels of 27 +/- 1 mmHg to 47 +/- 4 mmHg ( P less than 0.01). (asahq.org)
Summary1
  • PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics. (cdc.gov)
Produce1
  • Succinylcholine 1.5 mg kg − 1 does not produce more often excellent conditions compared with 1 mg kg − 1 , while 2.0 mg kg − 1 does, but the database with these regimens is weak and apnoea times remain unknown. (medscape.com)
Experience1
  • Until full demand can be met, in December or later, it is likely that providers will continue to experience shortages of succinylcholine. (asahq.org)
Conditions2
  • We performed a systematic review and meta-analysis of randomized trials comparing any succinylcholine regimen with the standard regimen (1.0 mg kg − 1 ) and reporting on intubating conditions and/or apnoea times. (medscape.com)
  • With succinylcholine regimens ≤0.5 mg kg − 1 , excellent intubating conditions are less likely and apnoea times are shorter, compared with 1 mg kg − 1 . (medscape.com)
Procedures1
  • In such instances, it is possible that procedures may need to be deferred until succinylcholine is available. (asahq.org)