Substance P: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Noonan Syndrome: A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.LEOPARD Syndrome: An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Stress Disorders, Traumatic: Anxiety disorders manifested by the development of characteristic symptoms following a psychologically traumatic event that is outside the normal range of usual human experience. Symptoms include re-experiencing the traumatic event, increased arousal, and numbing of responsiveness to or reduced involvement with the external world. Traumatic stress disorders can be further classified by the time of onset and the duration of these symptoms.Parasomnias: Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Parasomnias are generally divided into four groups: arousal disorders, sleep-wake transition disorders, parasomnias of REM sleep, and nonspecific parasomnias. (From Thorpy, Sleep Disorders Medicine, 1994, p191)Substance-Related Disorders: Disorders related to substance abuse.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Masturbation: Sexual stimulation or gratification of the self.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)Environmental Remediation: Removal of ENVIRONMENTAL POLLUTANTS or contaminants for the general protection of the environment. This is accomplished by various chemical, biological, and bulk movement methods, in conjunction with ENVIRONMENTAL MONITORING.Stress Disorders, Traumatic, Acute: A class of traumatic stress disorders that is characterized by the significant dissociative states seen immediately after overwhelming trauma. By definition it cannot last longer than 1 month, if it persists, a diagnosis of post-traumatic stress disorder (STRESS DISORDERS, POST-TRAUMATIC) is more appropriate.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.Anxiety Disorders: Persistent and disabling ANXIETY.Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.Syndrome: A characteristic symptom complex.Societies, Nursing: Societies whose membership is limited to nurses.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Pachyonychia Congenita: A group of inherited ectodermal dysplasias whose most prominent clinical feature is hypertrophic nail dystrophy resulting in PACHYONYCHIA. Several specific subtypes of pachyonychia congenita have been associated with mutations in genes that encode KERATINS.alpha-Synuclein: A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Frasier Syndrome: A syndrome characterized by CHRONIC KIDNEY FAILURE and GONADAL DYSGENESIS in phenotypic females with karyotype of 46,XY or female individual with a normal 46,XX karyotype. It is caused by donor splice-site mutations of Wilms tumor suppressor gene (GENES, WILMS TUMOR) on chromosome 11.Abnormalities, MultipleMutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Psychiatric Status Rating Scales: Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)Kidney Diseases, Cystic: A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Schizophrenic Psychology: Study of mental processes and behavior of schizophrenics.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Chernobyl Nuclear Accident: April 25th -26th, 1986 nuclear power accident that occurred at Chernobyl in the former USSR (Ukraine) located 80 miles north of Kiev.Depressive Disorder, Major: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Ectodermal Dysplasia: A group of hereditary disorders involving tissues and structures derived from the embryonic ectoderm. They are characterized by the presence of abnormalities at birth and involvement of both the epidermis and skin appendages. They are generally nonprogressive and diffuse. Various forms exist, including anhidrotic and hidrotic dysplasias, FOCAL DERMAL HYPOPLASIA, and aplasia cutis congenita.Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Synucleins: A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Substance Abuse Treatment Centers: Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.Lewy Bodies: Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Receptors, Neurokinin-1: A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.Phobic Disorders: Anxiety disorders in which the essential feature is persistent and irrational fear of a specific object, activity, or situation that the individual feels compelled to avoid. The individual recognizes the fear as excessive or unreasonable.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Psychometrics: Assessment of psychological variables by the application of mathematical procedures.Child Development Disorders, Pervasive: Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.Conduct Disorder: A repetitive and persistent pattern of behavior in which the basic rights of others or major age-appropriate societal norms or rules are violated. These behaviors include aggressive conduct that causes or threatens physical harm to other people or animals, nonaggressive conduct that causes property loss or damage, deceitfulness or theft, and serious violations of rules. The onset is before age 18. (From DSM-IV, 1994)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.tau Proteins: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).Diagnosis, Dual (Psychiatry): The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.United StatesNeuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Amyloid beta-Peptides: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Nerve Tissue ProteinsTic Disorders: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)Infant, Newborn: An infant during the first month after birth.Borderline Personality Disorder: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Thiobarbituric Acid Reactive Substances: Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Alcohol-Related Disorders: Disorders related to or resulting from abuse or mis-use of alcohol.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Somatoform Disorders: Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Humic Substances: Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antisocial Personality Disorder: A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)Marijuana Abuse: The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.Interview, Psychological: A directed conversation aimed at eliciting information for psychiatric diagnosis, evaluation, treatment planning, etc. The interview may be conducted by a social worker or psychologist.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Impulse Control Disorders: Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.Tachykinins: A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.Street Drugs: Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.Attention Deficit and Disruptive Behavior Disorders: Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Combat Disorders: Neurotic reactions to unusual, severe, or overwhelming military stress.Neurokinin-1 Receptor Antagonists: Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Mice, Inbred C57BLSpeech Disorders: Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Dysthymic Disorder: Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)Binge-Eating Disorder: A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)Psychotropic Drugs: A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).Cell Line: Established cell cultures that have the potential to propagate indefinitely.Neurokinin A: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.Dissociative Disorders: Sudden temporary alterations in the normally integrative functions of consciousness.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Residential Treatment: A specialized residential treatment program for behavior disorders including substance abuse. It may include therapeutically planned group living and learning situations including teaching of adaptive skills to help patient functioning in the community. (From Kahn, A. P. and Fawcett, J. Encyclopedia of Mental Health, 1993, p320.)Cognitive Therapy: A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.Temporomandibular Joint Disorders: A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Antimanic Agents: Agents that are used to treat bipolar disorders or mania associated with other affective disorders.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Opioid-Related Disorders: Disorders related or resulting from abuse or mis-use of opioids.Conversion Disorder: A disorder whose predominant feature is a loss or alteration in physical functioning that suggests a physical disorder but that is actually a direct expression of a psychological conflict or need.Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Learning Disorders: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These disorders may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.Performance-Enhancing Substances: Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. The substances can include PRESCRIPTION DRUGS; DIETARY SUPPLEMENTS; phytochemicals; and ILLICIT DRUGS.Personality Assessment: The determination and evaluation of personality attributes by interviews, observations, tests, or scales. Articles concerning personality measurement are considered to be within scope of this term.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Adolescent Behavior: Any observable response or action of an adolescent.Neurotic Disorders: Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Schizotypal Personality Disorder: A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.Child of Impaired Parents: Child with one or more parents afflicted by a physical or mental disorder.Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.Anxiety: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Child Behavior Disorders: Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Health Surveys: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.Mental Health Services: Organized services to provide mental health care.Psychotherapy: A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.Suicide, Attempted: The unsuccessful attempt to kill oneself.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Personality Inventory: Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.Bulimia Nervosa: An eating disorder that is characterized by a cycle of binge eating (BULIMIA or bingeing) followed by inappropriate acts (purging) to avert weight gain. Purging methods often include self-induced VOMITING, use of LAXATIVES or DIURETICS, excessive exercise, and FASTING.Stress, Psychological: Stress wherein emotional factors predominate.Impulsive Behavior: An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.Tobacco Use Disorder: Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.Marijuana Smoking: Inhaling and exhaling the smoke from CANNABIS.Juvenile Delinquency: The antisocial acts of children or persons under age which are illegal or lawfully interpreted as constituting delinquency.Antidepressive Agents: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.Adjustment Disorders: Maladaptive reactions to identifiable psychosocial stressors occurring within a short time after onset of the stressor. They are manifested by either impairment in social or occupational functioning or by symptoms (depression, anxiety, etc.) that are in excess of a normal and expected reaction to the stressor.Peroxisomal Disorders: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Life Change Events: Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Language Disorders: Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.Fetal Alcohol Spectrum Disorders: An umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.Body Dysmorphic Disorders: Preoccupations with appearance or self-image causing significant distress or impairment in important areas of functioning.Social Environment: The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.Violence: Individual or group aggressive behavior which is socially non-acceptable, turbulent, and often destructive. It is precipitated by frustrations, hostility, prejudices, etc.Models, Psychological: Theoretical representations that simulate psychological processes and/or social processes. These include the use of mathematical equations, computers, and other electronic equipment.Crime: A violation of the criminal law, i.e., a breach of the conduct code specifically sanctioned by the state, which through its administrative agencies prosecutes offenders and imposes and administers punishments. The concept includes unacceptable actions whether prosecuted or going unpunished.Agoraphobia: Obsessive, persistent, intense fear of open places.Controlled Substances: Drugs or chemical agents whose manufacture, possession, or use are regulated by government. This may include narcotics and prescription medications.United States Substance Abuse and Mental Health Services Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to substance abuse and mental health. It is commonly referred to by the acronym SAMHSA. On 1 October 1992, the United States Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) became SAMHSA.Congenital Disorders of Glycosylation: A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.Psychophysiologic Disorders: A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)Physalaemin: An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.Psychopathology: The study of significant causes and processes in the development of mental illness.Risk-Taking: Undertaking a task involving a challenge for achievement or a desirable goal in which there is a lack of certainty or a fear of failure. It may also include the exhibiting of certain behaviors whose outcomes may present a risk to the individual or to those associated with him or her.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Behavior, Addictive: The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.Social Behavior Disorders: Behaviors which are at variance with the expected social norm and which affect other individuals.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Alcohol-Induced Disorders: Disorders stemming from the misuse and abuse of alcohol.Family Therapy: A form of group psychotherapy. It involves treatment of more than one member of the family simultaneously in the same session.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Socioeconomic Factors: Social and economic factors that characterize the individual or group within the social structure.Factitious Disorders: Disorders characterized by physical or psychological symptoms that are not real, genuine, or natural.Receptors, Neurokinin-2: A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.Blood Platelet Disorders: Disorders caused by abnormalities in platelet count or function.Criminals: Persons who have committed a crime or have been convicted of a crime.Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.Peer Group: Group composed of associates of same species, approximately the same age, and usually of similar rank or social status.
Relative rates of AIDS among racial/ethnic groups by exposure categories. (1/7951)
The relative rates of acquired immunodeficiency syndrome (AIDS) were calculated among racial/ethnic populations using Centers for Disease Control and Prevention HIV (human immunodeficiency virus)/Surveillance reports assuming that racial/ethnic distributions reflect that of the US Census Data from 1990. For comparison, a rate of 1 was assigned to whites in each calculation. The overall relative rates were whites--1, African Americans--4.7, Hispanics--3, Asian/Pacific Islanders--0.4, and Native Americans--0.5. Acquired immunodeficiency syndrome surveillance data show higher rates of AIDS for African Americans and Hispanics compared with whites, Asians/Pacific Islanders, and Native Americans. The relative rates for African Americans and Hispanics compared with whites were highest for injecting drug users, heterosexual contact, and pediatric patients. These results led us to explore possible explanations for increased AIDS reporting in African Americans and Hispanics. We then explored available national datasets regarding those variables. The analyses indicate that variables such as access and receptivity to HIV prevention and treatment efforts, race/ethnicity, sexual behaviors, sexually transmitted diseases, socioeconomic status, and substance abuse interact in a complex fashion to influence HIV transmission and progression to AIDS in affected communities. (+info)A decade of caring for drug users entirely within general practice. (2/7951)
BACKGROUND: The government encourages general practitioners (GPs) to become involved in caring for drug users. However, in some areas of the country, including Bedford, secondary care support is inadequate. GPs in these areas have to decide how to cope with such patients entirely within general practice. AIM: To assess the characteristics and quality of care given without secondary care support to drug users by one practice in Bedford over a decade. METHOD: A search was made of the practice computer for all patients with a problem title of 'addiction drug' between 1986 and 1995. The age, sex, social characteristics, and drug history were recorded. RESULTS: One hundred and ninety-two patients were found, of which 155 took part in the practice programme; i.e. they consulted more than three times. Forty-three patients (37%) who took part and were prescribed Methadone were prescribed this drug as ampoules. Sixty-three patients (40.6%) who took part in the programme stopped using drugs. Thirty-two (33.6%) of the Methadone users became abstinent. A higher proportion of women (13-48%) than men (19-27.7%) stopped using Methadone (P = 0.019). Among patients who had a stable lifestyle, a higher proportion had been prescribed ampoules than mixture (22 out of 28: 78.6%; P = 0.001). Similarly, of those who had a job, eight out of 11 (72%; P = 0.037) had been prescribed methadone ampoules. Two-thirds of all patients prescribed amphetamines stopped using drugs. CONCLUSION: Long-term care of drug users entirely within general practice is feasible. Among those prescribed methadone ampoules, a higher than average proportion had stable lifestyles and had a stable job. (+info)Psychotropic drug use among women. (3/7951)
The consistent 2:1 ratio of women to men in the receipt of prescriptions for psychotropic drugs is reflected in the higher rates for women of neurotic illness, symptoms of both physical and mental discomfort, and help-seeking and drug-taking behaviour. Physicians' perceptions of the problems presented by their male and female patients influence their prescribing of these drugs. Recent statistics in Ontario indicate that greater use of physicians' services by women is an inadequate explanation of the higher rate of prescribing of psychotropic drugs to women. A longitudinal study of a large insured population in Ontario showed that almost twice the proportion of females, compared with males, received a prescription for psychotropic drugs in 1970-71 and in 1973-74, a higher proportion of females received multiple prescriptions for each drug class, and males were more likely than females to have received only one prescription in a year. (+info)Sexual harassment and generalized workplace abuse among university employees: prevalence and mental health correlates. (4/7951)
OBJECTIVES: This study hypothesized that interpersonal workplace stressors involving sexual harassment and generalized workplace abuse are highly prevalent and significantly linked with mental health outcomes including symptomatic distress, the use and abuse of alcohol, and other drug use. METHODS: Employees in 4 university occupational groups (faculty, student, clerical, and service workers; n = 2492) were surveyed by means of a mailed self-report instrument. Cross-tabular and ordinary least squares and logistic regression analyses examined the prevalence of harassment and abuse and their association with mental health status. RESULTS: The data show high rates of harassment and abuse. Among faculty, females were subjected to higher rates; among clerical and service workers, males were subjected to higher rates. Male and female clerical and service workers experienced higher levels of particularly severe mistreatment. Generalized abuse was more prevalent than harassment for all groups. Both harassment and abuse were significantly linked to most mental health outcomes for men and women. CONCLUSIONS: Interpersonally abusive workplace dynamics constitute a significant public health problem that merits increased intervention and prevention strategies. (+info)What's driving an epidemic? The spread of syphilis along an interstate highway in rural North Carolina. (5/7951)
OBJECTIVES: The purpose of this study was to determine whether county syphilis rates were increased along Interstate Highway 95 (I-95) in North Carolina during a recent epidemic. METHODS: Ecological data on syphilis cases demographic data, highway data, and drug activity data were used to conduct a cross-sectional and longitudinal study of North Carolina countries from 1985 to 1994. Crude and adjusted incidence rate ratios (IRRs) were determined by means of standard and longitudinal Poisson regression models adjusted for sociodemographic factors and drug use. RESULTS: Ten-year syphilis rates in I-95 counties greatly exceeded rates in non-I-95 counties (38 vs 16 cases per 100,000 persons) and remained higher after adjustment for race, age, sex, poverty, large cities, and drug activity (adjusted IRR = 2.05, 95% confidence interval [CI] = 1.84, 2.28). Syphilis rates were stable until 1989, when rates increased sharply in I-95 counties but remained stable in non-I-95 counties. Increased drug activity in I-95 counties preceded the rise in syphilis cases. CONCLUSIONS: A better understanding of the relationship between high-ways and the spread of sexually transmitted diseases may guide future prevention interventions. (+info)Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada. (6/7951)
OBJECTIVES: This study estimated morbidity and mortality attributable to substance abuse in Canada. METHODS: Pooled estimates of relative risk were used to calculate etiologic fractions by age, gender, and province for 91 causes of disease or death attributable to alcohol, tobacco, or illicit drugs. RESULTS: There were 33,498 deaths and 208,095 hospitalizations attributed to tobacco, 6701 deaths and 86,076 hospitalizations due to alcohol, and 732 deaths and 7095 hospitalizations due to illicit drugs in 1992. CONCLUSIONS: Substance abuse exacts a considerable toll on Canadian society in terms of morbidity and mortality, accounting for 21% of deaths, 23% of years of potential life lost, and 8% of hospitalizations. (+info)Mediators of ethnic-associated differences in infant birth weight. (7/7951)
PURPOSE: To examine whether ethnic differences in low birth weight babies of low-income women may be explained in part by group differences in prenatal health behaviors and psychosocial factors. METHODS: A prospective, survey of 1,071 low-income, primiparous African-American and Mexican-origin women was conducted in Los Angeles County, California. In face-to-face interviews, data were obtained on substance use, prenatal stress, social support, attitudes toward pregnancy, initiation of prenatal care, and medical risk. Medical chart data were abstracted regarding medical risk factors and labor, delivery, and neonatal data. Interview data were linked with birth outcome data retrieved from maternal medical records. Structural equation modeling was used to test a hypothesized model in which differences in birth weight were expected to be mediated by ethnic differences in substance use, psychosocial factors, and medical risk. RESULTS: As expected, African-American women delivered babies of earlier gestational age and lower birth weight than did women of Mexican origin. Direct predictors of low birth weight were use of drugs and cigarettes, prenatal stress, and positive attitudes toward pregnancy; together, these factors accounted for the observed ethnic differences in birth weight. CONCLUSION: These data contribute to our understanding of the factors that may account for ethnic-associated differences in low birth weight. (+info)Behavioral health benefits in employer-sponsored health plans, 1997. (8/7951)
Data for 1997 show that three-quarters or more of employer-sponsored health plans continue to place greater restrictions on behavioral health coverage than on general medical coverage. The nature of these restrictions varies by plan type. Some improvement in the treatment of mental health/substance abuse (MH/SA) benefits in employer plans may be occurring, however. Comparisons with data from 1996 show that the proportion of plans with benefits for "alternative" types of MH/SA services, such as nonhospital residential care, has increased. Further, the proportion with special limitations on these benefits shows a modest decrease. (+info)
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Compulsive sexual behavior - Diagnosis and treatment - Mayo Clinic
Drug addiction (substance use disorder) - Diagnosis and treatment - Mayo Clinic
SymptomsStimulantsDiagnosisDepressionAddictionAdolescentsCocaineMentalMisuseAnxiety and substance abuse disordersAdolescent Substance AbuseTobaccoDiagnosticComorbidityPreventionPatientsOpioidPresenting symptomsSchizophreniaWithdrawalAddictiveMood disordersPost traumatiBehavioralPrevalenceCannabisBipolarStimulantsMarijuanaAttention deficitBehaviorsAnxiety DisorderDiagnosesRelapseTreatmentAddictionsPsychosocialDepression2017Self-medicateCommonly abusedPsychotic DisorderComplicationsPsychoactive substanceAbuse disordersBenzodiazepinesDrugs and alcoholEating DisordersObsessive-compulsiEtiologyOnsetAdolescencePTSDMental health and substanceMajor depressiSUDsRates of substancePersonality disorderPsychosisPsychiatryAutism spectrumAdultsBehaviorPrevalent
Symptoms9
- Many physical disorders cause symptoms that mimic those of specific mental disorders. (merckmanuals.com)
- However those with anxiety disorders may find that alcohol or other substances can make their anxiety symptoms worse. (adaa.org)
- an anxiety disorder may lead to using alcohol or other substances to self-medicate or alleviate anxiety symptoms. (adaa.org)
- People suffering from this disorder often use alcohol or drugs to try to ease their anxiety, but substance abuse can exacerbate PTSD symptoms. (adaa.org)
- Many mental health professionals treat PTSD and substance abuse together because symptoms of PTSD (intrusive thoughts and sleep disturbance) can cause a substance abuse relapse. (adaa.org)
- Alcohol abuse commonly begins before or at the same time as panic disorder symptoms. (adaa.org)
- Symptoms are different for different substances. (blogspot.com)
- Substance use may be secondary to the psychopathology in various ways: Patients may use substances to self-medicate the symptoms of their mental disorder (for example, alcohol may be used to alleviate the symptoms of an anxiety disorder, such as social phobias). (wordpress.com)
- Patients may use substances to enhance symptoms of the mental disorder (as in the use of stimulants by manic patients). (wordpress.com)
Stimulants1
- The book discusses the effects of commonly abused substances, from tobacco and alcohol to stimulants and opioids, on the human brain and the various psychosocial routes to their misuse by adolescents. (worldcat.org)
Diagnosis2
- Sometimes this is referred to as concurrent disorder, dual diagnosis, dual disorders, co-morbidity and co-occurring substance abuse disorders and mental disorders. (wordpress.com)
- Co-occurring mental health and substance abuse problems can be described as one or more mental health diagnosis along with abuse of one or more substance. (wordpress.com)
Depression1
- About 20 percent of Americans with an anxiety or mood disorder such as depression have an alcohol or other substance use disorder, and about 20 percent of those with an alcohol or substance use disorder also have an anxiety or mood disorder. (adaa.org)
Addiction5
- Schedule I: These substances have a high addiction liability, no accredited medical use, and a lack of accepted safety. (merckmanuals.com)
- Schedule V: These substances have the least addiction liability. (merckmanuals.com)
- however, their treatment has been hindered in large part because of a long-standing "bench to practice" gap in which competencies for assessing, treating, and preventing substance use disorders are often lacking from health care education curricula ( The National Center on Addiction and Substance Abuse at Columbia University, 2012 ). (nursingcenter.com)
- Immediate and effective translation of recent advances in addiction research into routine clinical practice requires specialized training programs for health professionals involved in the care of patients and families affected by substance use disorders. (nursingcenter.com)
- Unfortunately, there is a systemic lack of curricula and comprehensive training programs for nurses to learn and practice evidence-based addiction care ( The National Center on Addiction and Substance Abuse at Columbia University, 2012 ). (nursingcenter.com)
Adolescents1
- The second edition of this book incorporates the latest theory, research, and best practices for understanding, treating, and preventing substance abuse among adolescents. (worldcat.org)
Cocaine1
- Some of the most common substance induced disorders are alcohol-induced depressive disorders, cocaine-induced psychotic disorders and stimulant-induced anxiety disorders. (wordpress.com)
Mental6
- A report from the Agency for Healthcare Research and Quality (AHRQ) finds that almost one in eight of the 95 million visits to hospital emergency departments made by adults in the United States in 2007 were due to a mental health and/or substance abuse problem. (adaa.org)
- Adolescent Substance Abuse, Second Edition, is a must-have reference for researchers, clinicians/practitioners, and graduate students in the fields of child and school psychology, social work, public health, developmental psychology, child and adolescent psychiatry, and various interrelated mental health and social policy arenas. (worldcat.org)
- Substance use problems are commonly seen in mental health. (wordpress.com)
- To encourage sensitivity to the stigmas associated to these terms, co- occurring mental health and substance abuse problems has been developed. (wordpress.com)
- The relationship between substance use and mental health disorders are multifaceted. (wordpress.com)
- Substance use may be causing the psychopathology (a substance- induced mental disorder). (wordpress.com)
Misuse2
- It updates the progress made in treatments for and prevention of the misuse of substances and adds new specific chapters on prescriptions, opiates, and methamphetamine abuse. (worldcat.org)
- The role of adolescent self-help in substance abuse interventions.Community-based interventions to reduce alcohol use and misuse. (worldcat.org)
Anxiety and substance abuse disorders2
- People with anxiety and substance abuse disorders are at an increased risk for abuse as well as potentially dangerous interactions when they use prescription medication. (adaa.org)
- Many therapists will use therapy for people with both anxiety and substance abuse disorders. (adaa.org)
Adolescent Substance Abuse2
- Topics featured in the book include:The effect of family and caregiver situations on adolescent substance abuse. (worldcat.org)
- A biological/genetic perspective on adolescent substance abuse. (worldcat.org)
Tobacco1
- Maternal substance abuse may consist of any combination of drug, chemical, alcohol, and/or tobacco use during the pregnancy. (blogspot.com)
Diagnostic1
Comorbidity1
- Learn more about comorbidity, or when two or more disorders or illnesses occur in the same person, either at the same time or one after the other. (adaa.org)
Prevention2
- In the US, the Comprehensive Drug Abuse Prevention and Control Act of 1970 and subsequent modifications require the pharmaceutical industry to maintain physical security of and strict record keeping for certain classes of drugs (controlled substances-see table Some Examples of Controlled Substances* ). (merckmanuals.com)
- The book offers new paths in diverse directions, analyzes the core components of substance use prevention, critiques emerging school-based interventions, and introduces a nuanced reconceptualization of recovery. (worldcat.org)
Patients1
- Substance use disorders involve a pathologic pattern of behaviors in which patients continue to use a substance despite experiencing significant problems related to its use. (merckmanuals.com)
Opioid1
- Although the unique roles, responsibilities, and scopes of practice of nurses and physicians often require separate training programs, blended interdisciplinary training may play a particularly important role in effectively managing substance use disorders and related harms, such as mitigating the risk of fatal overdose associated with overprescribing in the midst of the current opioid epidemic ( Gugelmann, Shofer, Meisel, & Perrone, 2013 ). (nursingcenter.com)
Presenting symptoms1
- this is simply known as substance use disorder and requires more presenting symptoms before a diagnosis is made. (wikipedia.org)
Schizophrenia5
- Severe mental disorders, such as schizophrenia, bipolar disorder and major depression affect 10% of these persons. (douglas.qc.ca)
- Schizophrenia and other psychotic disorders. (google.com)
- and non-substance-using male schizophrenia patients. (who.int)
- Since the early nineties of the last century, he ran projects on substance use treatment, treatment for patients with dual disorders (e.g., substance use and schizophrenia, personality disorders, or ADHD), on child maltreatment and sexual abuse, and on sexual involvement of health care professionals with their patients. (springer.com)
- He has been part of many publicly funded clinical trials testing the effects of interventions in children and adolescents, such as the Multimodal Treatment of Children with Attention Deficit Hyperactivity Disorder (MTA), the Treatment for Adolescents with Depression Study (TADS), the Research Units on Pediatric Psychopharmacology (RUPP) network studies, the Preschoolers with ADHD Treatment Study (PATS), and the Treatment of Early Onset Schizophrenia Study (TEOSS). (ebooks.com)
Withdrawal11
- Withdrawal is development of substance-specific syndrome after cessation or reduced intake of substance that had been used regularly. (mhmedical.com)
- Substance Dependance - the person will also be dealing with tolerance and withdrawal. (defyingshadows.com)
- Withdrawal is a substance specific reaction that is caused when a person stops using a substance on which they have become dependent. (defyingshadows.com)
- Withdrawal symptoms motivate the person to relapse and start using the substance again to get relief. (defyingshadows.com)
- Substance-related disorders are a class of psychiatric disorders characterized by a craving for, the development of a tolerance to, and difficulties in controlling the use of a particular substance or a set of substances, as well as withdrawal syndromes upon abrupt cessation of substance use. (amboss.com)
- This is not always the case, and abuse of a substance can be severe while some individuals dependent upon a drug to function may not misuse it as severely or have withdrawal symptoms. (theravive.com)
- There are two broad categories of patients who become dependent upon sedative-hypnotic or anxiolytic medications: those who take them for symptomatic treatment of a neurologic or psychiatric disorder and those who use them in non-medical settings, sometimes for self-medication for psychiatric symptoms but also to enhance euphoria or curb withdrawal from other drugs. (theravive.com)
- Meta-regressions indicated that treatment dropout results differed by substance targeted, and withdrawal/craving symptoms and treatment dropout differed by acupuncture type. (rand.org)
- Psychedelics can also set off psychotic symptoms, as can withdrawal from ethanol or other substances. (wikihow.com)
- If the psychosis occurs as a result of substance withdrawal, treatment should focus on withdrawal symptoms. (wikihow.com)
- This is because the effects of the substance or withdrawal from the substance have altered the person's perception of reality. (wikihow.com)
Addictive9
- While these substances may have different mechanisms of action, their addictive potential typically lies in the way they act on the brain's reward system and affect emotion, mood, and perception - producing what is colloquially referred to as a "high. (amboss.com)
- DSM-5 defines substance-related and addictive disorders in a distinct class of disorders. (amboss.com)
- The Diagnostic and Statistical Manual of Mental Disorders includes a chapter on "substance-related and addictive disorders. (medlexi.com)
- Subcategories include substance use disorder and addictive disorders . (medlexi.com)
- On Friday, April 24, 2015, CAMH's Addictions Rounds presented a webinar titled, "Substance-related and addictive disorders (SRAD) in Ontario adults with developmental disabilities (DD). (eenet.ca)
- Much of our text reading this week focuses on substance use and addictive disorders. (homeworkrank.com)
- Using the Ashford Library, access the Diagnostic and Statistical Manual 5 (DSM-5) using the instructions in the required resources section for this week and select one of the disorders in the section titled: "Substance-Related and Addictive Disorders. (homeworkrank.com)
- Utilizing the biopsychosocial perspective, explain the substance-related or addictive disorder and your research (reference article) through the model of health psychology. (homeworkrank.com)
- His main research areas are the neurobiological and neurocognitive processes underlying the pathogenesis of addictive disorders and the interaction with other psychiatric disorders. (springer.com)
Mood disorders8
- Homeless youth seem to be at elevated risk for a variety of mental health problems, including mood disorders, suicide attempts, and post traumatic stress disorder (Cauce et al. (hhs.gov)
- Mood disorders are characterized by marked disturbances in emotional state, which cause physical symptoms and affect thinking, social relationships, and behavior. (sparknotes.com)
- Mood disorders may be unipolar or bipolar . (sparknotes.com)
- Biological influences on mood disorders include genes , the neurotransmitters norepinephrine and serotonin , and brain abnormalities . (sparknotes.com)
- The onset and course of mood disorders may be influenced by stress. (sparknotes.com)
- Some of the most common mental health disorders among those with co-occurring disorders include mood disorders, anxiety disorders, personality disorders, and psychotic disorders. (psychcentral.com)
- Substance abuse often causes side effects which mimic symptoms of depression , anxiety, and mood disorders. (psychcentral.com)
- Mood Disorders in ASD. (ebooks.com)
Post traumati4
- Post-traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD) are often concurrent and develop as a result of a person being exposed to a traumatic event. (drugsandalcohol.ie)
- There is also accumulating evidence from animal studies investigating the effects of cannabidiol on fear memory processing indicating that it reduces learned fear in paradigms that are translationally relevant to phobias and post-traumatic stress disorder. (nottingham.ac.uk)
- Post-traumatic stress disorder is a set of psychological and physiological responses to a highly traumatic event. (sparknotes.com)
- What is more, the review - led by Zach Walsh, an associate professor of psychology at the University of British Columbia in Canada - suggests using marijuana could help alleviate symptoms of some mental health conditions, such as post-traumatic stress disorder (PTSD). (medicalnewstoday.com)
Behavioral8
- The essential feature of SUD is a cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues using the substance despite significant substance-related problems. (practicalpainmanagement.com)
- 16 Behavioral effects of SUDs (eg, repeated relapses and intense drug cravings) reflect brain changes that are evident even after detoxification when the individuals are exposed to drug-related stimuli. (practicalpainmanagement.com)
- Because individuals who suffer from anxiety disorders are more likely to self-medicate with alcohol and/or illicit drugs, treating co-occurring anxiety and substance abuse has been a challenge for behavioral health professionals. (ed4training.com)
- Topics of interest include, but are not limited to, problem/pathological gambling, substance abuse, alcohol and drug disorders, impulsive and antisocial behaviors, cannabis disorders and behavioral economics. (beds.ac.uk)
- This book presents credible reviews of contemporary empirical literature pertaining to selected behavioral, affective, and intellectual disorders, and their psychosocial assessment and treatment. (google.com)
- You will then research your selected disorder in the Annals of Behavioral Medicine or Behavioral Medicine publications. (homeworkrank.com)
- If you do not generate an appropriate article in the Annals of Behavioral Medicine or in the journal Behavioral Medicine, remove the journal titles and complete a general search for your disorder. (homeworkrank.com)
- Conduct disorder is a behavioral and emotional disorder marked by aggressive, destructive, or deceitful behavior. (psychcentral.com)
Prevalence7
- Given the high prevalence of trauma victims in all social, legal, and health-related services, a trauma-informed approach is required to appropriately respond to the needs of individuals. (drugsandalcohol.ie)
- The course addresses the prevalence of these disorders within society, with a special focus on the effects on the criminal justice system. (phoenix.edu)
- Determine the prevalence of disorders related to mood in society and the criminal justice system. (phoenix.edu)
- Determine the prevalence of anxiety disorders in society and the criminal justice system. (phoenix.edu)
- Substance users have the highest prevalence of hepatitis C virus (HCV) infection but have rarely been treated, largely because of their mistrust of the health care system, misconceptions about the consequences of the infection, and concerns regarding interferon-related side effects. (hepaton.com)
- Cannabis is the most commonly used psychoactive substance among pregnant women, with an estimated prevalence of use between 5 to 20% in in the United States. (clinicaltrials.gov)
- Prevalence, Treatment, And Unmet Treatment Needs Of US Adults With Mental Health And Substance Use Disorders. (drugabuse.gov)
Cannabis4
- Human epidemiologic studies across diverse populations have reported an emerging theme of deficiencies related to impulse control and executive functioning among offspring with in utero exposure to cannabis starting in adolescence. (clinicaltrials.gov)
- RAND researchers conducted a systematic review that synthesized evidence from randomized controlled trials of needle acupuncture - used adjunctively or as monotherapy - to provide estimates of its efficacy and safety for treating adults diagnosed with alcohol, opioid, stimulant, or cannabis use disorder. (rand.org)
- Research suggests that people may be using cannabis as an exit drug to reduce the use of substances that are potentially more harmful, such as opioid pain medication," Walsh explains. (medicalnewstoday.com)
- The prevalent comorbid substance use disorders were opioid (62.4%), tobacco (36.8%) and cannabis (28.5%) use disorders. (scinapse.io)
Bipolar3
- Bipolar disorders involve at least one period with manic symptoms and usually depressive periods as well. (sparknotes.com)
- A psychiatric evaluation is necessary to rule out other disorders with similar symptoms, including major depression and bipolar disorder . (medlexi.com)
- However, for patients with psychotic disorders - such as bipolar disorder - the team found non-medical marijuana use may be problematic. (medicalnewstoday.com)
Stimulants1
- Doering PL. Substance-Related Disorders: Overview and Depressants, Stimulants, and Hallucinogens. (mhmedical.com)
Marijuana7
- In a study by Dersh et al, 9 the most commonly misused/abused substances in patients presenting with chronic pain were alcohol (current and lifetime) and narcotics (current).The study did not consider marijuana and tobacco use. (practicalpainmanagement.com)
- Contrary to research that suggests marijuana may act as a gateway drug, encouraging the use of other harmful substances, a new study indicates it may have the opposite effect. (medicalnewstoday.com)
- The new review suggests marijuana may help treat substance use disorders and some mental health conditions. (medicalnewstoday.com)
- Additionally, many patients and advocates of medical marijuana claim the drug has the potential to treat mental health issues and substance use disorders, and the new study by Walsh and team suggests that, in some cases, these individuals may be right. (medicalnewstoday.com)
- The researchers came to their conclusion after conducting a systematic review of 60 studies assessing the effects of either medical or non-medical marijuana on mental health and substance abuse. (medicalnewstoday.com)
- Additionally, the review indicates that medical marijuana use may help some individuals with substance use disorders by acting as a substitute. (medicalnewstoday.com)
- The team concludes that more research is required to further assess the effects of marijuana use on mental health and substance abuse. (medicalnewstoday.com)
Attention deficit4
- ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. (springer.com)
- 2010 ). It has been suggested that the high rates of substance use-related problems may be attributed to comorbidity between ASD and attention deficit hyperactivity disorder (ADHD) (Palmqvist et al. (springer.com)
- New research finds that teens diagnosed with attention-deficit hyperactivity disorder ( ADHD ) and conduct disorder are more likely to use alcohol and tobacco. (psychcentral.com)
- Disruptive Behavioural Disorders, Attention Deficit Hyperactivity Disorder in ASD. (ebooks.com)
Behaviors8
- Substance use disorders involve a pathologic pattern of behaviors in which patients continue to use a substance despite experiencing significant problems related to its use. (merckmanuals.com)
- All classes of substances taken in excess directly activate the brain reward system, which is involved in reinforcing behaviors and producing memories. (practicalpainmanagement.com)
- Medical screening for physical and mental disorders with associated harmful behaviors and substance-related disorders among persons overseas applying for U.S. immigration status and non-immigrants who are required by law to have an overseas medical examination, hereafter referred to as applicants, is an essential component of the immigration-related medical evaluation. (cdc.gov)
- The required examination includes evaluation of physical and mental disorders with associated harmful behaviors and substance-related disorders. (cdc.gov)
- These new instructions are to be followed when determining whether an individual is afflicted with physical and mental disorders with associated harmful behaviors and substance-related disorders among all applicants. (cdc.gov)
- To determine the likelihood of recurrence of harmful behaviors associated with a physical or mental disorder. (cdc.gov)
- Compulsive drug-taking behaviors include uncontrolled use of the drug, craving the drug, excessive amounts of time devoted to obtaining the drug, unsuccessful attempts to cut down or control substance use, and giving up important and pleasurable activities in order to obtain the drug. (mentalhealthgateway.org)
- The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships between these behaviors. (rxivist.org)
Anxiety Disorder9
- A chronic, high level of anxiety may be a sign of an anxiety disorder . (sparknotes.com)
- Generalized anxiety disorder involves persistent and excessive anxiety for at least six months. (sparknotes.com)
- Symptoms vary depending on the specific anxiety disorder. (health.am)
- Approximately one-third of patients presenting with anxiety have a medical etiology for their psychiatric symptoms, but an anxiety disorder can also present with somatic symptoms in the absence of a diagnosable medical condition. (health.am)
- Some individuals appear resilient to stress, while others are vulnerable to stress, which precipitates an anxiety disorder. (health.am)
- an anxiety disorder may lead to using alcohol or other substances to self-medicate or alleviate anxiety symptoms. (adaa.org)
- The co-occurrence of substance abuse, particularly alcohol abuse, is common among people who have social anxiety disorder . (adaa.org)
- Read more about social anxiety disorder and alcohol abuse . (adaa.org)
- Treating substance abuse will not eliminate an anxiety disorder, so it's usually necessary to treat both together, particularly to lessen the chance of relapse. (adaa.org)
Diagnoses2
- In addition to the diagnoses described above, the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) lists "other specified feeding or eating disorder" as a category that applies to people who have eating habits that do not fit into another category such as bulimia nervosa or anorexia nervosa. (recovery.org)
- Treatment often includes education regarding both substance abuse and mental health diagnoses and how they are related. (psychcentral.com)
Relapse8
- These disorders are associated with abnormally persistent emotional memories and inadequate treatment, often leading to symptom relapse. (nottingham.ac.uk)
- In addition, co-occurring anxiety and substance abuse also has a high possibility of relapse. (ed4training.com)
- If left untreated, these problems can play a role in a person returning to substance abuse, thus a variety of medications and continued psychotherapy is necessary to help the patient identify stressful situations and objects in the environment that can trigger relapse. (mentalhealthgateway.org)
- Individuals with co-occurring disorders are more vulnerable to relapse and worsening of mental health issues. (psychcentral.com)
- Dr. David Warner of Mayo Clinic's Department of Anesthesiology and the American Board of Anesthesiology board of directors said the incidence of this disorder is continuing to increase and the risk of relapse or death is high. (upi.com)
- Residents who develop substance use problems are at high risk for relapse after treatment or, in some cases, die as a result of the disorder. (upi.com)
- Many mental health professionals treat PTSD and substance abuse together because symptoms of PTSD (intrusive thoughts and sleep disturbance) can cause a substance abuse relapse. (adaa.org)
- Alcohol or drugs often cause panic attacks, and having panic disorder is a risk factor for a relapse among people with a substance abuse disorder. (adaa.org)
Treatment34
- Treatment centers for eating disorders and substance abuse may offer inpatient or outpatient services, although inpatient care is usually used for those with these coinciding conditions. (recovery.org)
- Patients being treated for a substance use disorder commonly report chronic, noncancer pain, 3 and, in turn, a history of SUD occurs frequently among patients who receive treatment for chronic, noncancer pain. (practicalpainmanagement.com)
- OBJECTIVES To determine the effectiveness of TC versus other treatments for substance dependents, and to investigate whether effectiveness is modified by client or treatment characteristics. (semanticscholar.org)
- Efficacy of the therapeutic community model in the treatment of drug use-related problems: a systematic review]. (semanticscholar.org)
- The Gold Standard' and Related Considerations for a Maturing Science of Substance Abuse Treatment. (semanticscholar.org)
- Under Australia's National Illicit Drug Strategy, a National Comorbidity Initiative was established to improve service coordination and treatment outcomes for people with coexisting mental health and substance use disorders. (aihw.gov.au)
- Another group with special treatment needs are veterans from armed conflict, as substance use disorders and PTSD are more frequent among these populations. (drugsandalcohol.ie)
- Trauma-focused therapies for PTSD are effective for veterans, however services that integrate both SUD and PTSD treatment while considering specific war-related traumas should be established for veteran populations. (drugsandalcohol.ie)
- Understanding how cannabidiol regulates emotion and emotional memory processing may eventually lead to its use as a treatment for anxiety-related and substance abuse disorders. (nottingham.ac.uk)
- Describe intervention techniques for treatment of disorders related to mood. (phoenix.edu)
- However, there is still a strong need for research focusing on the influence of attachment on TA in substance use disorder (SUD) treatment. (biomedcentral.com)
- With the development of highly efficacious, interferon-free therapeutic regimens without significant side effects, the concept of colocating HCV and substance use treatment would appear to be highly feasible. (hepaton.com)
- This process has been further facilitated by widespread clinical adaptation of noninvasive assays for fibrosis assessment, which could be performed routinely in substance use treatment facilities. (hepaton.com)
- Negative attitudes toward people with prescription opioid use disorder were prevalent, but a majority believed that treatment could be effective. (nih.gov)
- Journal of Substance Abuse Treatment , 8 , 9-17. (springer.com)
- Journal of Substance Abuse Treatment , 8 , 19-28. (springer.com)
- Journal of Substance Abuse Treatment , 8 , 29-33. (springer.com)
- The biology and treatment of gambling disorder. (medlineplus.gov)
- Guidelines for detoxification and substance abuse treatment, including as they apply to LSD and other hallucinogens , have been established by the Substance Abuse and Mental Health Services Administration . (medscape.com)
- Patients with a history of substance abuse should be referred for drug treatment, while patients who require admission should have consultation with a medical toxicologist or regional poison control center. (medscape.com)
- A comprehensive treatment approach will address both disorders at the same time. (drugabuse.gov)
- 52.5% of those with co-occurring conditions received neither mental health care not substance use treatment. (drugabuse.gov)
- 3.9% of those with co-occurring conditions received substance use treatment only. (drugabuse.gov)
- For more information about finding treatment or yourself or a loved one, visit, drugabuse.gov/related-topics/treatment . (drugabuse.gov)
- The best treatment for co-occurring disorders is commonly referred to as an integrated approach. (psychcentral.com)
- This method of treatment simultaneously combines the treatment of both mental health and substance abuse disorders. (psychcentral.com)
- These individuals may require longer treatment than those who have a single disorder because they often experience more crises and progress is generally slower. (psychcentral.com)
- The findings also suggest that mental health, substance abuse, and criminal justice outcomes remain dependent on the treatment intervention received, perhaps moderated by type of diversion intervention, rather than on a generic and initial diversion event. (nih.gov)
- Your treatment depends on the drug used and any related medical or mental health disorders you may have. (mayoclinic.org)
- If substances are found to be the cause of the psychosis, treatment can help. (wikihow.com)
- If psychosis resulted from recreational drugs, it's important to identify what substances occur within the body to direct treatment. (wikihow.com)
- BACKGROUND: Benzodiazepine (BZD) misuse in opioid-maintained patients is widespread and has been related to poorer treatment success. (mendeley.com)
- The book is designed to be highly relevant to clinical work and the organization of care systems and meets the real need for a European perspective on dual disorders that takes into account the realities of European treatment organization. (springer.com)
- Through our Substance Use Disorders Portfolio - made possible by the generosity and vision of Foundation donors - we're working with a comprehensive network of partners to implement proven prevention strategies, expand access to treatment and support recovery. (nhcf.org)
Addictions5
- It has also now been linked to severe brain damage leading to an inability to control behaviours, which could explain why many people who abuse substances go on to develop addictions. (wikipedia.org)
- If you are struggling with an eating disorder you may have developed other addictions, including drug abuse or alcohol abuse . (recovery.org)
- Substance abuse, like alcoholism or drug addictions, can make symptoms of eating disorders worse, so addicted individuals will likely need to go through detoxification before the rehabilitation aspect of the program begins. (recovery.org)
- Gambling disorder is thought to involve many of the same neurobiological mechanisms as substance-related addictions and shares some of the same psychosocial risk factors. (amboss.com)
- Addictions to alcohol or drugs also affect more than half of the homeless population with mental disorders. (douglas.qc.ca)
Psychosocial1
- Psychosocial support to tackle trauma-related symptoms and related substance use disorders. (drugsandalcohol.ie)
Depression5
- It is also very common for someone who suffers from a substance-related disorders to experience other mental health problems such as anxiety or depression as well. (queensu.ca)
- Long term abuse has been linked to personality changes such as depression, paranoia, anxiety which can be related to psychological disorders. (wikipedia.org)
- Depression may be related to experiences of loss. (sparknotes.com)
- Anhedonia is a core symptom of major depressive disorder , therefore individuals experiencing this symptom can be diagnosed with depression, even in the absence of low/depressed mood. (wikipedia.org)
- About 20 percent of Americans with an anxiety or mood disorder such as depression have an alcohol or other substance use disorder, and about 20 percent of those with an alcohol or substance use disorder also have an anxiety or mood disorder. (adaa.org)
20171
- This is the peer reviewed version of the following article: Lee, J. L. C., Bertoglio, L. J., Guimarães, F. S., and Stevenson, C. W. (2017) Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. (nottingham.ac.uk)
Self-medicate1
- One may try to self-medicate with substances to reduce mental health symptoms. (psychcentral.com)
Commonly abused2
- She explains that a genetic component has been implicated with which of the following commonly abused substances? (nurseslabs.com)
- Commonly abused substances include alcohol , nicotine , and illegal drugs. (medlexi.com)
Psychotic Disorder1
- What is a psychotic disorder? (mentalhealthfirstaid.ca)
Complications3
- There are many potential complications that can arise due to substance abuse such as severe physiological damage, psychological changes and social changes that are often not desirable. (wikipedia.org)
- Substance abuse is also often associated with premature ageing, fertility complications, brain damage and a higher risk of infectious diseases due to a weakened immune system. (wikipedia.org)
- Developing an understanding of substance abuse is key to finding solutions to the problems related to it and preventing further complications. (medlexi.com)
Psychoactive substance1
- Substance use-related problems have traditionally been considered rare in autism spectrum disorders (ASD), since the core features appeared to reduce the risk of using psychoactive substance. (springer.com)
Abuse disorders4
- Both aversive and appetitive memories are therefore powerful drivers of behaviour, but the inappropriate expression of conditioned responding to fear- and drug-related stimuli can develop into anxiety-related and substance abuse disorders respectively. (nottingham.ac.uk)
- What Are the Current Costs and Outcomes Related to Mental Health and Substance Abuse Disorders? (kff.org)
- People with anxiety and substance abuse disorders are at an increased risk for abuse as well as potentially dangerous interactions when they use prescription medication. (adaa.org)
- Many therapists will use therapy for people with both anxiety and substance abuse disorders. (adaa.org)
Benzodiazepines1
- Benzodiazepines in psychotic and related conditions. (springer.com)
Drugs and alcohol2
- One study found that 50% of people with an eating disorder abused drugs and alcohol compared to 9% in the general population. (recovery.org)
- Negative examples from singers, movie stars and others in the media that glorify drugs and alcohol have also been shown to influence substance abuse in some people. (medlexi.com)
Eating Disorders15
- According to the National Institutes of Health (NIH), substance abuse and eating disorders frequently co-occur. (recovery.org)
- Certain personality traits, such as impulsiveness, have been linked to substance abuse and eating disorders. (recovery.org)
- There are several types of eating disorders that someone can experience. (recovery.org)
- Each of these conditions may be treated best in an inpatient facility that is trained to deal with eating disorders and substance abuse. (recovery.org)
- Eating disorders are characterized by problematic eating patterns, concerns about body weight, and inappropriate efforts to control weight. (sparknotes.com)
- Some people may have a genetic vulnerability to eating disorders. (sparknotes.com)
- Eating disorders may be associated with particular personality traits. (sparknotes.com)
- Cultural factors strongly influence the onset of eating disorders. (sparknotes.com)
- Lacking autonomy in the family and having an overly weight-conscious mother may influence the onset of eating disorders. (sparknotes.com)
- People with eating disorders tend to have certain distortions of thinking. (sparknotes.com)
- Sexual and eating disorders. (google.com)
- Eating disorders and substance use disorders frequently co-occur. (rxivist.org)
- Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [rg], twin-based=0.23-0.53). (rxivist.org)
- Feeding and Eating disorders in ASD. (ebooks.com)
- Eating Disorders Working Group of the Psychiatric Genomics Consortium (2020). (bris.ac.uk)
Obsessive-compulsi2
- Obsessive-compulsive disorder entails obsessions , compulsions , or both. (sparknotes.com)
- Although it shares features of obsessive compulsive disorder, compulsive gambling is likely a different condition. (medlineplus.gov)
Etiology1
- Classification allows psychologists to describe disorders, predict outcomes, consider treatments, and study etiology. (sparknotes.com)
Onset5
- Chronic, noncancer pain is common among patients being treated for a substance use disorder but studies indicate that such disorders are more than 90% likely to appear before the onset of pain symptoms. (practicalpainmanagement.com)
- 6 As noted, 94% of chronic pain patients with lifetime SUDs experience the onset of these disorders before the onset of their chronic pain. (practicalpainmanagement.com)
- Biological factors implicated in the onset of anxiety disorders include genes , different sensitivity to anxiety , the neurotransmitters GABA and serotonin , and brain damage . (sparknotes.com)
- Early onset of substance abuse is a significant public health concern," said William Brinkman, M.D., a pediatrician at Cincinnati Children's Hospital Medical Center and the study's lead author. (psychcentral.com)
- Alcohol abuse usually develops after the onset of this disorder. (adaa.org)
Adolescence1
- Disorders typically diagnosed in infancy, childhood, or adolescence. (google.com)
PTSD2
- PTSD and substance abuse commonly occur together. (adaa.org)
- People suffering from this disorder often use alcohol or drugs to try to ease their anxiety, but substance abuse can exacerbate PTSD symptoms. (adaa.org)
Mental health and substance3
- Research on perceived unmet need for care for mental health and substance use problems focuses on general populations to the detriment of hidden populations. (nih.gov)
- The survey included the Perceived Need for Care Questionnaire, which assessed unmet need for care for mental health and substance use problems across seven service types. (nih.gov)
- Street-involved people who use drugs experience very high rates of perceived unmet need for care for mental health and substance use problems. (nih.gov)
Major depressi4
- Anhedonia occurs in roughly 70% of people with a major depressive disorder. (wikipedia.org)
- Major depressive disorder involves at least one period with significant depressive symptoms. (sparknotes.com)
- Significant genetic correlations were adjusted for variants associated with major depressive disorder (MDD). (rxivist.org)
- The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. (bris.ac.uk)
SUDs1
- The ability to recognize and treat substance use disorders (SUDs) is a core competence in psychosomatic medicine. (ecstasy.com.ua)
Rates of substance3
- This is common, as the rates of substance abuse are much higher among individuals with an eating disorder. (recovery.org)
- Hoffman et al indicated that 23.4% of chronic pain patients met criteria for active alcohol (9.7%), analgesic (12.6%), or sedative use (7.0%), and an additional 9.4% were in remission 11 (see Table 1 for rates of substance abuse associated with chronic pain). (practicalpainmanagement.com)
- New Hampshire's young people have among the highest rates of substance use in the country. (nhcf.org)
Personality disorder2
- It is often reported that substance abuse coincides with personality disorders, such as borderline personality disorder. (wikipedia.org)
- Avoidant Personality Disorder does not generaly impact on an individuals intellectual or physical capacities. (health.am)
Psychosis1
- Psychosis can occur as a result of using or withdrawing from almost any substance, and it does not matter if the person used the substance for a long period or just a short time. (wikihow.com)
Psychiatry1
- Adolescent Substance Abuse, Second Edition, is a must-have reference for researchers, clinicians/practitioners, and graduate students in the fields of child and school psychology, social work, public health, developmental psychology, child and adolescent psychiatry, and various interrelated mental health and social policy arenas. (worldcat.org)
Autism spectrum1
- This is a concise clinical reference on the state of the art of diagnosing and treating comorbidities in patients with autism spectrum disorder (ASD). (ebooks.com)
Adults5
- Many disorders seen in adults can occur in children. (health.am)
- 7.7 million adults have co-occurring mental and substance use disorders. (drugabuse.gov)
- Of the 20.3 million adults with substance use disorders, 37.9% also had mental illnesses. (drugabuse.gov)
- Among the 42.1 million adults with mental illness, 18.2% also had substance use disorders. (drugabuse.gov)
- A report from the Agency for Healthcare Research and Quality (AHRQ) finds that almost one in eight of the 95 million visits to hospital emergency departments made by adults in the United States in 2007 were due to a mental health and/or substance abuse problem. (adaa.org)
Behavior13
- Substance use disorders generally involve behavior patterns in which people continue to use a substance despite having problems caused by its use. (merckmanuals.com)
- Inadmissibility based on a physical or mental disorder is limited to applicants with associated harmful behavior or potentially harmful behavior. (