An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.
An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.
Cell surface proteins that bind TACHYKININS with high affinity and trigger intracellular changes influencing the behavior of cells. Three classes of tachykinin receptors have been characterized, the NK-1; NK-2; and NK-3; which prefer, respectively, SUBSTANCE P; NEUROKININ A; and NEUROKININ B.
A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364)
A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Disorders related to substance abuse.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.
A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.
Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
A class of cell surface receptors for tachykinins that prefers neurokinin B (neurokinin beta, neuromedin K) over other tachykinins. Neurokinin-3 (NK-3) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.
Dodecapeptide tachykinin found in the central nervous system of the amphibian Kassina senegalensis. It is similar in structure and action to other tachykinins, but is especially effective in contracting smooth muscle tissue and stimulating the micturition reflex.
Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
A family of hexahydropyridines.
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Use of electric potential or currents to elicit biological responses.
The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.
The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A potent mast cell degranulator. It is involved in histamine release.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Elements of limited time intervals, contributing to particular results or situations.
A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.
The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38)
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network. (1/2566)

Paired intracellular recordings have been used to examine the activity-dependent plasticity and neuromodulator-induced metaplasticity of synaptic inputs from identified inhibitory and excitatory interneurons in the lamprey spinal cord. Trains of spikes at 5-20 Hz were used to mimic the frequency of spiking that occurs in network interneurons during NMDA or brainstem-evoked locomotor activity. Inputs from inhibitory and excitatory interneurons exhibited similar activity-dependent changes, with synaptic depression developing during the spike train. The level of depression reached was greater with lower stimulation frequencies. Significant activity-dependent depression of inputs from excitatory interneurons and inhibitory crossed caudal interneurons, which are central elements in the patterning of network activity, usually developed between the fifth and tenth spikes in the train. Because these interneurons typically fire bursts of up to five spikes during locomotor activity, this activity-dependent plasticity will presumably not contribute to the patterning of network activity. However, in the presence of the neuromodulators substance P and 5-HT, significant activity-dependent metaplasticity of these inputs developed over the first five spikes in the train. Substance P induced significant activity-dependent depression of inhibitory but potentiation of excitatory interneuron inputs, whereas 5-HT induced significant activity-dependent potentiation of both inhibitory and excitatory interneuron inputs. Because these metaplastic effects are consistent with the substance P and 5-HT-induced modulation of the network output, activity-dependent metaplasticity could be a potential mechanism underlying the coordination and modulation of rhythmic network activity.  (+info)

Molecular dynamics study of substance P peptides in a biphasic membrane mimic. (2/2566)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in a TIP3P water/CCl4 biphasic solvent system as a mimic for the water-membrane system. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) in the equilibration stage of the simulation. The starting orientation/position of the peptides for the MD simulation was either parallel to the water/CCl4 interface or in a perpendicular/insertion mode. In both cases the peptides equilibrated and adopted a near-parallel orientation within approximately 250 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained in the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbone of nearly all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions with the hydrophobic phase come from the hydrophobic interactions of the side chains of Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, and Phe-7, Leu-10, Met-11 and, to a lesser extent, Tyr-8 in SP-Y8. Concerted conformational transitions took place in the time frame of hundreds of picoseconds. The concertedness of the transition was due to the tendency of the peptide to maintain the necessary secondary structure to position the peptide properly with respect to the water/CCl4 interface.  (+info)

Molecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelle. (3/2566)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) during the equilibration stage of the simulation. It was shown that when SP-Y8 was initially placed in an insertion (perpendicular) configuration, the peptide equilibrated to a surface-bound (parallel) configuration in approximately 450 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained from the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbones of all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions come from the hydrophobic interaction between the side chains of Lys-3, Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, from Lys-3, Phe-7, Leu-10, and Met-11 in SP-Y8, and the micellar interior. Significant interactions, electrostatic and hydrogen bonding, between the N-terminal residues, Arg-Pro-Lys, and the micellar headgroups were observed. These latter interactions served to affect both the structure and, especially, the flexibility, of the N-terminus. The results from simulation of the same peptides in a water/CCl4 biphasic cell were compared with the results of the present study, and the validity of using the biphasic system as an approximation for peptide-micelle or peptide-bilayer systems is discussed.  (+info)

Two affinities for a single antagonist at the neuronal NK1 tachykinin receptor: evidence from quantitation of receptor endocytosis. (4/2566)

1. In smooth muscle contractility assays, many NK1 receptor (NK1r) antagonists inhibit responses to the neurotransmitter, substance P (SP), and its analogue, septide, with markedly different potency, leading to the proposal that there is a septide-preferring receptor related to the NK1r. 2. We used fluorescence immunohistochemistry and confocal microscopy to visualize agonist-induced NK1r endocytosis and analyse agonist/antagonist interactions at native NK1r in neurons of the myenteric plexus of guinea-pig ileum. 3. SP and septide gave sigmoid log concentration-response curves and were equipotent in inducing NK1r endocytosis. 4. The NK1r antagonists, CP-99994 (2S,3S)-3-(2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride and MEN-10581, cyclo(Leu,[CH2NH]Lys(benzyloxycarbonyl)-Gln-Trp-Phe-betaAla) were both more potent in inhibiting endocytosis (50 x and 8 x greater respectively) against septide than against SP. 5. The results suggest that SP and septide interact differently with the NK1r, and that a single antagonist can exhibit different affinities at a single NK1r population, depending on the agonist with which it competes. Thus it may not be necessary to posit a separate septide-preferring tachykinin receptor.  (+info)

Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. (5/2566)

To assess the role of lung sensory C fibers during and after inhalation of 1 part/million ozone for 8 h, we compared breathing pattern responses and epithelial injury-inflammation-repair in rats depleted of C fibers by systemic administration of capsaicin as neonates and in vehicle-treated control animals. Capsaicin-treated rats did not develop ozone-induced rapid, shallow breathing. Capsaicin-treated rats showed more severe necrosis in the nasal cavity and greater inflammation throughout the respiratory tract than did control rats exposed to ozone. Incorporation of 5-bromo-2'-deoxyuridine (a marker of DNA synthesis associated with proliferation) into terminal bronchiolar epithelial cells was not significantly affected by capsaicin treatment in rats exposed to ozone. However, when normalized to the degree of epithelial necrosis present in each rat studied, there was less 5-bromo-2'-deoxyuridine labeling in the terminal bronchioles of capsaicin-treated rats. These observations suggest that the ozone-induced release of neuropeptides does not measurably contribute to airway inflammation but may play a role in modulating basal and reparative airway epithelial cell proliferation.  (+info)

Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. (6/2566)

The substance P receptor (SPR) is a G protein-coupled receptor (GPCR) that plays a key role in pain regulation. The SPR desensitizes in the continued presence of agonist, presumably via mechanisms that implicate G protein-coupled receptor kinases (GRKs) and beta-arrestins. The temporal relationship of these proposed biochemical events has never been established for any GPCR other than rhodopsin beyond the resolution provided by biochemical assays. We investigate the real-time activation and desensitization of the human SPR in live HEK293 cells using green fluorescent protein conjugates of protein kinase C, GRK2, and beta-arrestin 2. The translocation of protein kinase C betaII-green fluorescent protein to and from the plasma membrane in response to substance P indicates that the human SPR becomes activated within seconds of agonist exposure, and the response desensitizes within 30 s. This desensitization process coincides with a redistribution of GRK2 from the cytosol to the plasma membrane, followed by a robust redistribution of beta-arrestin 2 and a profound change in cell morphology that occurs after 1 min of SPR stimulation. These data establish a role for GRKs and beta-arrestins in homologous desensitization of the SPR and provide the first visual and temporal resolution of the sequence of events underlying homologous desensitization of a GPCR in living cells.  (+info)

Neurogenic plasma leakage in mouse airways. (7/2566)

1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or substance P on microvascular plasma leakage in the trachea and lungs of male pathogen-free C57BL/6 mice. 2. Single bolus intravenous injections of capsaicin (0.5 and 1 micromol kg(-1), i.v.) or substance P (1, 10 and 37 nmol kg(-10, i.v.) failed to induce significant leakage in the trachea, assessed as extravasation of Evans blue dye, but did induce leakage in the urinary bladder and skin. 3. Pretreatment with captopril (2.5 mg kg(-1), i.v.), a selective inhibitor of angiotensin converting enzyme (ACE), either alone or in combination with phosphoramidon (2.5 mg kg(-1), i.v.), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. The increase was reversed by the bradykinin B2 receptor antagonist Hoe 140 (0.1 mg kg(-1), i.v.). 4. After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung. This increase was reversed by the tachykinin (NK1) receptor antagonist SR 140333 (0.7 mg kg(-1), i.v.), but not by the NK2 receptor antagonist SR 48968 (1 mg kg(-1), i.v.). 5. Experiments using Monastral blue pigment as a tracer localized the leakage to postcapillary venules in the trachea and intrapulmonary bronchi, although the labelled vessels were less numerous in mice than in comparably treated rats. Blood vessels of the pulmonary circulation were not labelled. 6. We conclude that neurogenic inflammation can occur in airways of pathogen-free mice, but only after the inhibition of enzymes that normally degrade inflammatory peptides. Neurogenic inflammation does not involve the pulmonary microvasculature.  (+info)

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (8/2566)

We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. OT-7100 did not inhibit prostaglandin E2 biosynthesis at 10(-8)-10(-4) M. Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. Single oral doses of 0.1, 0.3, 1 and 3 mg/kg OT-7100 were effective on the hyperalgesia induced by substance P in which indomethacin had no effect. Repeated oral administration of OT-7100 (10 and 30 mg/kg) was effective in normalizing the mechanical nociceptive threshold in the injured paw without affecting the nociceptive threshold in the uninjured paw in the Bennett model. Indomethacin had no effect in this model. While amitriptyline (10 and 30 mg/kg) and clonazepam (3 and 10 mg/kg) significantly normalized the nociceptive threshold in the injured paw, they also increased the nociceptive threshold in the uninjured paw. These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia.  (+info)

TY - JOUR. T1 - Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. AU - Mantyh, P. W.. AU - Pinnock, R. D.. AU - Downes, C. P.. AU - Goedert, M.. AU - Hunt, S. P.. PY - 1984/12/1. Y1 - 1984/12/1. N2 - The undecapeptide substance P is a neurotransmitter candidate in the mammalian central and peripheral nervous system1. Although the distribution of substance P-like immunoreactivity within the central nervous system (CNS) is well established2, the recent identification and autoradiographic localization of specific substance P-binding sites has revealed numerous areas of mismatch between peptide levels and numbers of such sites3-6. Previous studies have shown that substance P stimulates the hydrolysis of inositol phospholipids in peripheral tissues and in the hypothalamus7,8, probably through stimulation of a polyphosphoinositide-specific phospholipase C (refs 9-11). Inositol phospholipid hydrolysis has been implicated in the mobilization of cytosolic calcium ...
We present data demonstrating the gene expression of substance P and its receptor in human peripheral blood-isolated monocytes and macrophages. Using the RT-PCR assay, preprotachykinin-A (substance P) mRNA is detected in human peripheral blood-isolated monocytes and macrophages. Among the alpha, beta, and gamma transcripts of the substance P gene, only the beta and gamma transcripts are detectable in these cells. By Southern blot assay these RT-PCR-amplified transcripts are recognized using a specific substance P probe. Sequence analysis of the RT-PCR products from both monocytes and macrophages also confirmed the structure of these transcripts, which are identical to those found in human neuronal cells. At the protein level, both human monocytes and macrophages produced endogenous substance P as determined by an enzyme immunoassay. Capsaicin, a vanillyl fatty acid amide (ingredient of hot pepper), released substance P from both human monocytes and macrophages. In addition, using nested RT-PCR ...
The centrally induced effects of angiotensin II and substance P on the cardiovascular system and on neuronal efferent activity of the splanchnic, renal, and adrenal nerves were investigated in chronically instrumented conscious rats. The pressor responses to substance P injected into the lateral brain ventricle were accompanied by marked and short latency increases in heart rate, cardiac output, splanchnic, renal, and adrenal nerve activity, and a rise in plasma noradrenaline and adrenaline. Behaviorally, an arousal-type reaction was observed. In contrast, the pressor responses to intracerebroventricular angiotensin II were associated with initial decreases in heart rate, cardiac output, splanchnic, renal, and adrenal nerve activity, and a fall in plasma noradrenaline at the time of the maximal blood pressure increase. In some but not all animals, a second blood pressure peak associated with increases in heart rate and splanchnic nerve activity was observed after several minutes. Incomplete ...
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
This study tested the hypothesis that DPP4 inhibition potentiates the vascular effects of substance P during ACE inhibition. We found no effect of combined DPP4 and ACE inhibition on substance P-mediated vasodilation; however, during concurrent DPP4 and ACE inhibition, intra-arterial administration of substance P stimulated the sympathetic nervous system. In addition, DPP4 inhibition diminished substance P-induced tPA release in women.. This study extends the findings of 3 previous studies examining the interactive effect of ACE inhibition and DPP4 inhibition on blood pressure. Marney et al14 reported that the DPP4 inhibitor sitagliptin reduced blood pressure in subjects with the metabolic syndrome when given alone for 5 days. When given in combination with an ACE inhibitor, however, sitagliptin attenuated the hypotensive response to ACE inhibition and caused an increase in heart rate and circulating norepinephrine concentrations.14 Boschmann et al15 reported a significant increase in ...
The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating the irritant effect of this product. It also relates to the use of a substance P antagonist for the preparation of a pharmaceutical composition for topical application containing at least one product with an irritant side effect for reducing or even eliminating the irritant effect of this product. The substance P antagonist may be a peptide compound or a nitrogen-containing compound or a nitrogen-, sulphur- or oxygen-containing heterocyclic compound.
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL), and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalization in the dorsal horn after electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a significantly higher ...
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are up-regulated in low-threshold myelinated primary afferents following certain types of nerve injury, and that release of substance P from these afferents contributes to the resulting tactile allodynia. To test this hypothesis, we looked for neuropeptides in Aβ primary afferent terminals in the ipsilateral gracile nucleus and spinal dorsal horn in three nerve injury models: sciatic nerve transection (SNT), spinal nerve ligation (SNL) and chronic constriction injury (CCI). We also looked for evidence of neurokinin 1 (NK1) receptor internalisation in the dorsal horn following electrical stimulation of Aβ afferents. We found no evidence of either substance P or CGRP expression in injured Aβ terminals in the spinal cord in any of the models. Although substance P was not detected in terminals of injured afferents in the gracile nucleus, CGRP was expressed in between 32 and 68% of these terminals, with a ...
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RATIONALE: Diagnostic procedures, such as positron emission tomography (PET) using [18F]-labeled substance P antagonist receptor quantifier, may be effe
Central or peripheral administration of substance P (SP) produces a number of effects on behavior. In mice, SP decreases isolation-induced aggressive [1] and nociceptive [2] behaviors. SP alters...
1. The presence of immunoreactive substance P (I-SP) in the vagus nerve of 5 species was demonstrated by radioimmunoassay. Different amounts of SP per unit weight were found: Guinea pig > cat >...
Blog on Substance P [Delta-Aminovaleryl6, Pro9, N-Me-Leu10] peptide product: The Substance P [Delta-Aminovaleryl6, Pro9, N-Me-Leu10] n/a (Catalog #MBS658288) is a Peptide produced fr...
The P in substance P [SP] is mistakenly thought to signify Pain or Psychiatric substance. Substance P (P standing for Preparation or Powder) is a neuropeptide - but only nominally so, as it is ubiquitous. Its receptor - the neurokinin type 1 - is distributed over cytoplasmic and nuclear membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16]. Substance P is a key first responder to most noxious/extreme stimuli (stressors), i.e., those with a potential to compromise biological integrity. SP is thus regarded as an immediate defense, stress, repair, survival system. The molecule, which is rapidly inactivated (or at times further activated by peptidases) is rapidly released - repetitively and chronically, as warranted, in the presence of a stressor. Unique among biological processes, SP release (and expression of its NK1 Receptor ...
New research from the University of Adelaide has shown for the first time that the growth of brain tumours can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.. The discovery has been made during a study looking at the relationship between brain tumours and a peptide associated with inflammation in the brain, called substance P.. Substance P is commonly released throughout the body by the nervous system, and contributes to tissue swelling following injury. In the brain, levels of substance P greatly increase after traumatic brain injury and stroke.. Researchers have known for some time that levels of substance P are also greatly increased in different tumour types around the body, says Dr Elizabeth Harford-Wright, a postdoctoral fellow in the Universitys Adelaide Centre for Neuroscience Research.. We wanted to know if these elevated levels of the peptide were also present in brain tumour cells, and if so, whether or not they were ...
TY - JOUR. T1 - Substance P regulates Th1-type colitis in IL-10 knockout mice. AU - Weinstock, Joel V.. AU - Blum, Arthur. AU - Metwali, Ahmed. AU - Elliott, David. AU - Bunnett, Nigel. AU - Arsenescu, Razvan. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-γ production. IL-10 -/- mice given a nonsteroidal anti-inflammatory drug (NSAID) develop Th1 colitis. We studied the importance of SP and NK-1R in this colitis model. LP T cells were isolated to study their NK-1R expression. LP T cells from IL-10 -/- mice expressed NK-1R and produced IFN-γ only after NSAID treatment and induction of colitis. LP T cells from NSAID-treated wild-type controls or from age-matched untreated IL-10 -/- animals did not express NK-1R or produce IFN-γ. Experiments showed that IL-12 induced NK-1R transcription in CD4 + T cells cultured in vitro. However, T cells cultured with IL-12 and ...
Ma W, Ribeiro-da-Silva A, De Koninck Y, Radhakrishnan V, Henry JL, Cuello AC. 1996. Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord.. J Comp Neurol. 376(1):45-64. ...
Clin obstet gynecol 2002;188:447-390. Both oral and intestinal phases of both anovaginal and rvfs (fig. [from greek arachne a spider] arithmophobia numbers. C: The fascia was intact in the electrical current can be tested by listing the most serious problem associated with anxiety, and substance p. 494 disorders neuropathic (or neurogenic pain) arises from unfavourable comparisons between just one simple portion of the pelvis. Top auricular adj. Philadelphia, pa: Wolters kluwer health/lippincott williams & wilkins > table of contents > section vi - surgery for ovarian endometriomata. Top 7 the appearance of the glycoside by the acid secretion is profoundly influenced by the. Crystalline lens n. The more appropriate pressure within the pick up an endogenous substance, resulting in arrested physical development and growth factors, igf i and type (ovulatory or anovulatory) in most cases will respond to drug induced hypotension. Gracile nucleus n. Either of the activity of nondepolarising muscle ...
Vascular endothelial cells respond to certain vasoactive agents by releasing factors which act on medial smooth muscle to cause relaxation or contraction of blood vessels. One of the substances responsible for endothelium-dependent relaxation to acetylcholine has recently been identified as nitric oxide. We have tested the hypothesis that the ability of vascular endothelium to cause relaxation in response to stimulation by vasoactive agents is related in some way to the pattern of perivascular innervation. The actions of acetylcholine and substance P were tested in the presence of methoxamine induced tone in the isolated perfused mesenteric arterial bed of the rat. Tissues were tested from untreated normal 12 week old Sprague-Dawley rats and from rats which had been treated from birth with capsaicin to prevent the development of peptidergic perivascular innervation or 6-hydroxydopamine to prevent development of catecholaminergic innervation. Concentration dependent endothelium-dependent ...
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Learn More ...
en] A radioimmunoassay of the undecapeptide substance P (SP) and its application in rabbit lung superfusate has been developed. The assay was based on the use of a radioactive tracer, 125I-SP-Tyr8, which showed, with an excess of antibodies, a specific binding greater than 90% and a nonspecific binding lower than 2%. This tracer was stable for 4 weeks at -20 degrees C. Its specific radioactivity was 384 Ci/mmol. The assays lower limit of detection was 10 pg/ml (0.7 fmol). The determination of SP in rabbit lung perfusate required extraction and concentration using octadecylsilane cartridges. Under these conditions, the recovery of SP from experiments on lung perfusates (n=4) was 75.0+/-4.5%, and the intraassay and interassay coefficients of variation were 7.3+/-1.9% and 10.7+/-1.3%, respectively. Amounts of SP released in rabbit lung perfusates were determined following stimulation of pulmonary C fibers with capsaicin (10(-4) M). During the stimulation period, the values of SP from lung ...
. After my post on the exciting research published in Great Britain on Botox Chimeras earlier today, Dr. Robert Caudle graciously notified me of his teams recent research publication on Botox conjugates injected into the cerebral spinal fluid cisterns in mice. The abstract is below: . Anti-nociceptive effect of a conjugate of substance P and…
Several categories of drugs are identical to or derived from biological products. Some hormones given as drugs, for example, require special mention because the drug name differs from the name used for the endogenous substance (please note that this is not a comprehensive list of such drugs). Other categories of biologicals are derived from specific guidelines developed by USAN, outlined below. Using the appropriate name can help clarify that the substance referred to is a drug, although for less familiar drug names it may be necessary to include the endogenous hormone name in parentheses to clarify the action of the Less ...
Members from the solute carrier category of transporters are in charge of the cellular uptake of a wide selection of endogenous substances and xenobiotics in multiple cells. only (http://www.membranetransport.org/Accessed: August 2011). Although many of these transporters possess unfamiliar physiologic function, many have gained curiosity within the medical community at an increasing price, which arrives, in part, towards the reputation that medicines may hitchhike on these protein that normally action on endogenous substrates. As the idea of a transporter-mediated motion of certain medications in and out of cells had been suggested in the 1950s (Lotspeich, 1958), it had been not before first solute providers had been cloned in the 1990s that field really flourished (Grundemann et al., 1994; Jacquemin et al., 1994; Sekine et al., 1997; Sugary et al., 1997). Since that time, the physiological and pharmacological function of many transporter protein continues to be studied in an array of healing ...
Phosphate is an important part of nucleic acid, a large number of which exists in the human body, it is a kind of harmless endogenous substances, which can help drugs […]. Read More → ...
Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance having an epitope, bound to a label and capable of moving within the test device. The test device further comprises a second substance immobilized to the test device and spatially separated from the first substance. The second substance has an epitope substantially similar to the epitope of the first substance. Upon application to the test device, the polyvalent analyte binds to the first substance and moves within the test device to the location of the second substance with both polyvalent analyte and first substance are immobilized at location of the second substance. Polyvalent analyte is detected by the presence of the label at the location of the second substance. Also disclosed is a control substance for use with the device that can be used to determine completion of the test and viability of the device.
De Koninck Y, Ribeiro-da-Silva A, Henry JL, Cuello AC. 1992. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts.. Proc Natl Acad Sci U S A. 89(11):5073-7. ...
De Koninck Y, Ribeiro-da-Silva A, Henry JL, Cuello AC. Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. Proc Natl Acad Sci USA. 1992;89(11):5073-7. ...
NPs can expect to encounter clients requiring prescriptions for controlled substances, since many medications are controlled substances. You should plan for this anticipated client care need by establishing strategies consistent with College standards and guidelines. You should also work with your employer to ensure you have access to resources for meeting client needs. In this case, the resource you need is the ability to refer to a health professional such as an NP or physician authorized to prescribe controlled substances. The clients prescription must be filled out by the authorized prescriber in a manner that is consistent with their regulatory obligations. NPs who are not authorized to prescribe controlled substances must not taper a controlled substance or renew a prescription for a controlled substance as these are considered prescribing.. If you commonly encounter clients in your practice that require controlled substances you should consider completing the education requirement that ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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The original scripts I wrote were to save time and facilitate an eDirectory upgrade. The scripts have evolved into simple, basic, time saving proactive management scripts. I wanted to share the scripts with the Cool Solutions readers (with the usual disclaimers of use at your own risk). Ive since updated the scripts, revisited and retouched them for different needs, but here is the latest that ive been using. I use the %if variable command now on NetWare 6 and Ive removed all Wait for text commands that were reading the system console for text strings, and replaced them with pauses. The NetWare 6 Logger Screen changed where the output was going, and rather than get fancy I just went with the pause.. AT a minimum, youll need STUFFKEY.NLM and TOOLBOX.NLM. I also use DELAYCMD.NLM and theyre all ideally scheduled with CRON (Ive included 3 example CRONTAB files). Ive included an old version of TOOLBOX.NLM I used to use in case youre not patched to the latest and greatest SP levels on all ...
The original scripts I wrote were to save time and facilitate an eDirectory upgrade. The scripts have evolved into simple, basic, time saving proactive management scripts. I wanted to share the scripts with the Cool Solutions readers (with the usual disclaimers of use at your own risk). Ive since updated the scripts, revisited and retouched them for different needs, but here is the latest that ive been using. I use the %if variable command now on NetWare 6 and Ive removed all Wait for text commands that were reading the system console for text strings, and replaced them with pauses. The NetWare 6 Logger Screen changed where the output was going, and rather than get fancy I just went with the pause.. AT a minimum, youll need STUFFKEY.NLM and TOOLBOX.NLM. I also use DELAYCMD.NLM and theyre all ideally scheduled with CRON (Ive included 3 example CRONTAB files). Ive included an old version of TOOLBOX.NLM I used to use in case youre not patched to the latest and greatest SP levels on all ...
In adult animals treated as neonates with the sympathetic neurotoxin 6-hydroxydopamine, a virtual absence of TH-IR and NPY-IR fibers was observed, whereas the distribution of CGRP-IR and SP-IR fibers appeared unaltered ...
The inability of CP-96,345 to inhibit caudally directed biting and scratching produced in mice by a single i.t. injection of SP presents an interesting paradox concerning the identity of receptors with which this compound interacts to elicit its effects in vivo. This is especially true as the doses of CP-96,345 tested readily inhibited other effects, including NMDA activity, desensitization to the behavioral effects of SP and sensitization to KA. If SP-induced behaviors are exclusively the result of NK-1 activation, CP-96,345 and CP-99,994 would be expected to inhibit the response to SP as they are potent inhibitors of [3H]SP binding (Snider et al., 1991). Our data suggest that either the response to a single injection of SP is not mediated by activation of NK-1 sites, or that CP-96,345 and CP-99,994 also bind, with an even greater affinity, to a site distinct from the NK-1 receptor to affect EAA activity.. Although it is possible that SP induces a behavioral response in mice that is not ...
Teatrul SubPământ. Valea Jiului după 1989 este un proiect de observație cotidiană și analiză critică a existenței unor comunități afectate decisiv de schimbarea politică din anii 90. Proiectul își propune să documenteze situația economică, viața și munca minerilor în post-socialism. Teatrul SubPământ este un proiect de reconstrucție performativă a poveștilor-document care fundamentează istoria comunităților din Valea Jiului, aflate la limita dintre supraviețuire, migrație, dispariție și posibilă reconstrucție.. Spectacolul Sub Pământ are la bază o cercetare în Valea Jiului, coordonată de Mihaela Michailov (dramaturg), Vlad Petri (fotograf), David Schwartz (regizor). Cercetarea a avut mai multe direcţii - ateliere, discuţii libere şi interviuri cu mineri, soții de miner, pensionari, paznici de mină, lideri de sindicat, oameni care trăiesc din furtul de cărbune, copii.. Sub Pământ este un spectacol-arhivă de povești-mărturii ale unor comunități ...
The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
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Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
The table below is the Annex XVII to REACH and includes all the restrictions adopted in the framework of REACH and the previous legislation, Directive 76/769/EEC. Each entry shows a substance or a group of substances or a substance in a mixture, and the consequent restriction conditions. The latest consolidated version of REACH presents the restrictions adopted until the date of publication. Subsequent changes are included in the amending Commission regulations.. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Water, sugar and table salt are common examples of neutral substances. The pH scale rates substances based on how acidic or basic they are. A substance that is not acidic or basic is described as a...
Again in this section you will find articles that pertain to substance abuse. Information on the substances are manufactured and distributed. Along with important information pertaining to how these substances can destroy ones body and ruin their life
TY - JOUR. T1 - Local effect of substance P on colonic motor activity in different experimental states. AU - Hou, J.. AU - Otterson, M. F.. AU - Sarna, S. K.. PY - 1989. Y1 - 1989. N2 - We studied the effects of close intra-arterial injections of substance P on colonic motor activity in the conscious state, during anesthesia, and during acute laparotomy. In the conscious state, with enteric nerves intact, substance P stimulated postsynaptic cholinergic neurons to induce a large amplitude and long duration contraction. This response was blocked by prior close intra-arterial injection of atropine and tetrodotoxin (TTX) but not hexamethonium. Hexamethonium and TTX given alone, close intra-arterially, induced a series of short-duration contractions. Prior close intra-arterial administration of hexamethonium significantly enhanced the colonic motor response to substance P. After blockade of nerve conduction by TTX, substance P induced a series of short-duration contractions with characteristics ...
In rat parotid acinar cells prelabelled with [3H]inositol, substance P (100 nM) induced the formation of [3H]inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Ins(1,4,5)P3 reached a maximum 7 s after substance P stimulation, and thereafter decreased and reached a stable value at 60 s. When the cells were exposed to substance P for 10, 30, 60, or 300 s, washed, and re-exposed to this peptide, the formation of [3H]inositol trisphosphate (InsP3) was attenuated in a time-dependent manner. In the cells pretreated as described above, the number of [3H]substance-P-binding sites (Bmax) was also decreased. Possible role(s) of Ca2+ and protein kinase (protein kinase C) control mechanisms in regulating substance P responses were investigated. Desensitization of substance P-induced InsP3 was not affected by the Ca2+ ionophore ionomycin, nor was it dependent on Ca2+ mobilization. On the other hand, in the presence of 4 beta-phorbol 12,13-dibutyrate (PDBu) and 12-O-tetradecanoyl-4 beta-phorbol 13-acetate, known ...
Title:The Impact of Substance P on the Pathogenesis of Insulin Resistance Leading to Gestational Diabetes. VOLUME: 15 ISSUE: 1. Author(s):Jolanta Patro-Malysza, Zaneta Kimber-Trojnar, Katarzyna Skorzynska-Dziduszko, Beata Marciniak, Dorota Darmochwal-Kolarz, Jacek Bartosiewicz, Bozena Leszczynska-Gorzelak and Jan Oleszczuk. Affiliation:Department of Obstetrics and Perinatology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland.. Keywords:Gestational diabetes, insulin receptor substrate, insulin resistance, metabolism, pregnancy, substance P.. Abstract:Gestational diabetes mellitus is one of the most often medical conditions during pregnancy affecting 5-6% of all pregnancies. The etiology of gestational diabetes is not clearly understood. In obesity and diabetes mellitus type 2, abnormal insulin signaling is an important agent mediating the increase of insulin resistance. Insulin receptor substrate serine phosphorylation is a time-controlled physiological reaction in insulin ...
Substance P is a member of the tachykinin family of neuropeptides that plays an important role in pain transmission, neurogenic inflammatory diseases and the adaptive response to stress. Substance P exerts its biological activities via binding to a G-protein coupled receptor of the neurokinin (NK) receptor family. Here, we show by Western blot experiments that substance P induced a transient synthesis of the zinc finger transcriptional regulator Egr-1 in human glioma cells. Substance P-induced stimulation of Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor. These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis. Moreover, we show that the signaling cascade
Semantic Scholar extracted view of Block of the hyoscine-resistant opiate withdrawal contracture of ileum by a new substance P antagonist [D-Arg1,D-Phe5,D- Trp7,9,Leu 11]substance P. by K Tsou et al.
The report generally describes substance p, examines its uses, production methods, patents. SUBSTANCE P market situation is overviewed; substance p
Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut following chemotherapy administration. Neurokinin-1 is also known as Tachykinin Receptor 1 (TACR1), Neurokinin 1 Receptor (NK1R), and Substance P Receptor (SPR). By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system, rolapitant prevents late-phase CINV. Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and late-phase CINV during the first 120 hours post-chemotherapy.
The purpose of this study is to compare the levels of Substance P in saliva, in patients with severe chronic low back pain and in subjects without it. In addition, to explore a possible cutoff point, in order to define normal and pathological levels of Substance P in saliva. The ultimate objective would be to design a measurement method for use in routine clinical practice ...
BackgroundMiscarriage is a common complication of early pregnancy, mostly occurring in the first trimester. However, the etiological factors and prognostic and diagnostic biomarkers are not well known. Neurokinin-1 receptor (NK-1R) is a receptor of tachykinin peptide substance P (SP) and has a role in various pathological conditions, cancers, but its association with miscarriages and significance as a clinicopathological parameter are not studied. Accordingly, the present study aimed to clarify the localization and expression for NK-1R in human retained products of conception (POC). The role of NK-1R is not known in miscarriages.Materials and MethodsNK-1R expression was assessed in POC and normal placental tissues by immunohistochemistry. Three- to four-micrometer-thin sections of formalin-fixed paraffin-embedded tissues were used for this purpose. Tissues were processed and then immunohistochemically stained with NK-1R antibody. Brain tissue was used as control for antibody. Protein expression was
FIG. 1. Sensitivity and linearity analysis of the NK-1R real-time RT-PCR. A reading of change in fluorescence (Rn) as a function of cycle numbers is demonstrated for a range of known input copy numbers of the NK-1R RNA transcript derived from the plasmid containing NK-1R cDNA fragment. Tenfold serial dilutions of the NK-1R RNA starting from 102 to 107 molecules per reaction were amplified by the real-time RT-PCR. (A) The standard curve of the serial dilutions of the NK-1R RNA with a correlation coefficient (R2) of 0.9988. (B) Amplification plot of the serial dilutions of NK-1R RNA. The dynamic detection range is 5 orders of magnitude from 102 to 107 molecules, and the detection sensitivity is 100 NK-1R mRNA copies per reaction. NC, negative control which lacked PCR-amplified product when reverse transcriptase was omitted from the RT reaction using 107 molecules of NK-1R RNA standard. ...
Pain and neurotransmitters. Article date: 1990/9/1 PubMed ID: 2747035 Journal name: Cellular and molecular neurobiology (ISSN: 0272-4340) ABSTRACT 1. To study physiological roles of substance P (SP), gamma-aminobutyric acid (GABA), enkephalins and other endogenous substances, we developed several kinds of isolated spinal cord preparations of newborn rats. 2. In these preparations, various slow responses of spinal neurons evoked by stimulation of primary afferent C fibers were depres…
Neonatal Society Abstract: Wong CM, Boyle EM, Laing IA, Stephen RI, Smith J, McIntosh N. 2003. Plasma substance P and neurokinin A in neonates - variation with gestation and postnatal age.
Substance P (SP) is a therapeutic peptide that has been widely used to induce angiogenesis and tissue regeneration. However, its therapeutic efficacy is often limited due to rapid degradation in vivo and a short half-life (1 min) after systemic administration. In the present study, we chemically modified SP with polyethylene glycol (PEG) to generate long-lasting formulations with increased stability and extended retention time in vivo and evaluated their ability to enhance therapeutic angiogenesis. Compared to the unmodified SP, PEGylated SP (PEG-SP) exhibited significantly increased half-life in vivo ('360-fold increase in normal mouse and (similar to)120-fold increase in diabetic mouse). Systemic injection of PEG SP led to a marked increase in therapeutic efficacy and angiogenesis in diabetic hindlimb ischemia, as evident from the remarkable improvement in salvage of ischemic limb and recovery of blood perfusion in diabetic mice with limb ischemia. These formulations increased endogenous ...
Wang, T.; Axelsson, M.; Jensen, J.; Conlon, J.M., 2000: Cardiovascular actions of python bradykinin and substance P in the anesthetized python, Python regius
Several categories of drugs are identical to or derived from biological products. Some hormones given as drugs, for example, require special mention because the drug name differs from the name used for the endogenous substance (please note that this is not a comprehensive list of such drugs). Other categories of biologicals are derived from specific guidelines developed by USAN, outlined below. Using the appropriate name can help clarify that the substance referred to is a drug, although for less familiar drug names it may be necessary to include the endogenous hormone name in parentheses to clarify the action of the
In this part, the terms listed in this section have the following meanings: Adulterated specimen. A specimen that has been altered, as evidenced by test results showing either a substance that is not a normal constituent for that type of specimen or showing an abnormal concentration of an endogenous substance. Affiliate. Persons are affiliates of one another if, directly or indirectly, one controls or has the power to control the other, or a third party controls or has the power to control both. Indicators of control include, but are not limited to: interlocking management or ownership; shared interest among family members; shared facilities or equipment; or common use of employees. Following the issuance of a public interest exclusion, an organization having the same or similar management, ownership, or principal employees as the service agent concerning whom a public interest exclusion is in effect is regarded as an affiliate. This definition is used in connection with the public interest ...
The environmental procarcinogen which are responcible for carcinogenesis, to form the proximate carcinogen, they require metabolic activation by drug metabolizing enzymes. The CYP3A subfamily enzymes play an important role in elimination of drugs. The substrates for CYP3A4 enzyme include drugs, and endogenous substances. Therefore, allelic changes in the coding regions ...
Rosso, M; Robles-Frías, MJ; Coveñas, R; Salinas-Martín, MV; Muñoz, M (2008). „The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic action of substance P on human gastrointestinal cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 29 (4): 245-54. PMID 18781096. doi:10.1159/000152942 ...
The studies of CYP1A2 expression are mainly focused on the liver to understand its role with respect to biotransformation and metabolism of exogenous substances and endogenous hormones (Mikhailova et al., 2006; Sugiyama et al., 2019). In the recent days, CYP1A2 expression in the other tissues including the pancreas, lung and ovary has been investigated (Vukovic et al., 2016; Hwang et al., 2020). Especially, there have been several articles identified that the expression of CYP family in the ovary is affected by several internal or external factors. The expression of ovarian CYP1B1 was increased under estrogen treatment (Symonds et al., 2006) or during evening of proestrus than other estrus cycles for metabolism of serum estradiol (Dasmahapatra et al., 2002). In addition, the expressions of CYP2E1, CYP2A and CYP2B were dependent on the follicle size of the ovary (Cannady et al., 2003). Furthermore, the ovarian CYP1A1 was increasingly expressed after treatment of 3MC and dexamethasone in the pig ...
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II ...
A list of Occupations and the hazardous substances that employees come in contact with in these professions; compiled by Heritage Research Center, Ltd.
WASHINGTON -- Cancer patients are about to get new help in preventing the vomiting that can be debilitating during chemotherapy -- a pill that blocks nausea impulses in the brain. The Food and Drug Administration cleared sale Wednesday of Emend, the first drug approved to prevent delayed nausea. Vomiting and subsequent dangerous weight loss can be so severe that some patients cant tolerate what could be lifesaving cancer treatment. A number of antinausea drugs work to prevent the retching that happens almost immediately after a chemotherapy session, but not the very common delayed type that strikes a day or so later. A brain chemical called substance P, best known for its role in communicating pain, is involved in the post-chemotherapy nausea reflex, explained FDA gastrointestinal drugs chief Robert Justice. Emend works by blocking receptors in the brain needed for substance P to latch onto to send its nausea signals. In studies, adding Emend to standard stomach-settling therapy allowed 20 ...
JNeurosci Print ISSN: 0270-6474 Online ISSN: 1529-2401. The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturers claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.. ...
Our later investigations confirm our previous results.. 1. It is possible to increase markedly the effect of substances inhibiting tumor growth by using certain combinations of these substances which, when given alone, have some effect on tumor growth.. 2. Immunity acquired against the effect of these substances depends partly upon an active immunization of the tumor cells themselves against the action of these substances, and this immunity is transmitted to the following generations of tumor cells.. 3. The immunity against the substances inhibiting tumor growth is, as far as we have investigated the problem, specific.. 4. Our later experiments provide a more secure basis for the additional and more general conclusions which we mentioned tentatively in our previous paper.. ...
Data & statistics on Primary substances of abuse by Race African Asian: Primary substances of abuse by Race, Primary substance of abuse by race (East London), Duration of Use of the Primary Substance of Abuse among Adult First-time Admissions, by Race/Ethnicity, Gender, and Primary Substance of Abuse: 2009...
Its exciting that this milestone was realized with a substance from a Korean patent considering our earlier reports that Asian scientists are disclosing more chemical research in patents, said Christine McCue, vice president of marketing at CAS. This year alone, 63 percent of all chemical patents covered by CAS originated in Asia. Our team of scientists analyzes documents in more than 50 languages, including more than 20 Asian languages, and is uniquely qualified to uncover important chemistry patented by scientists worldwide.. Similar to the 60 millionth substance registered in May 2011, the 70 millionth substance again reflects the value of patents as an important source of chemical information. In fact, more than 70 percent of new substances from the literature registered in 2012 originated from patents. To ensure the completeness and quality of the CAS premier substance collection, CAS scientists analyze, organize and curate chemistry in patents from 63 patent authorities around the ...
Photo: http://photos.prnewswire.com/prnh/20121206/CL25687) Its exciting that this milestone was realized with a substance from a Korean patent considering our earlier reports that Asian scientists are disclosing more chemical research in patents, said Christine McCue, vice president of marketing at CAS. This year alone, 63 percent of all chemical patents covered by CAS originated in Asia. Our team of scientists analyzes documents in more than 50 languages, including more than 20 Asian languages, and is uniquely qualified to uncover important chemistry patented by scientists worldwide.. Similar to the 60 millionth substance registered in May 2011, the 70 millionth substance again reflects the value of patents as an important source of chemical information. In fact, more than 70 percent of new substances from the literature registered in 2012 originated from patents. To ensure the completeness and quality of the CAS premier substance collection, CAS scientists analyze, organize and curate ...
9781118306642 Our cheapest price for Emerging Perspectives on Substance Misuse is $60.82. Free shipping on all orders over $35.00.
Substance withdrawal is a group of symptoms that occur upon the abrupt discontinuation or decrease in ones intake of a substance. Withdrawal develops after a physical or mental dependence, which is caused by consuming substances for an extended period of time. It is dose dependent and varies based upon the substance consumed, the duration of intake, as well as the route of administration used.
Manufacture: means the production, preparation, propagation, compounding, conversion or processing of, or to produce, prepare, propagate, compound, convert or process, a controlled substance or controlled substance analog, directly or indirectly, by extraction from substances of natural origin, chemical synthesis or a combination of extraction and chemical synthesis, including to package or repackage or the packaging or repackaging of the substance, or to label or to relabel or the labeling or relabeling of its container. See Wisconsin Statutes 961.01 ...
Practitioners from enterprises dealing with chemicals and dangerous substances, labour inspectorates, environmental authorities and academia from different disciplines, are encouraged to enrol in a training organised by NIVA education on Alternative Assessment and Substitution of Dangerous Substances at Workplaces.. The course will take place 21 - 23 April 2020 in Helsinki. If you are interested in this course, please register before 20 March 2020.. Learn about the Healthy Workplace Manage Dangerous Substances campaign 2018-19. Discover EU-OSHAs publications on the substitution of dangerous substances. ...
In the U.S., men who have sex with men (MSM) continue to constitute the greatest number of HIV/AIDS cases compared with other risk groups. Furthermore, many episodic substance using men who have sex with men (SUMSM) report that sex and substance use always or often go together. Studies have shown that substance use just before or during sex substantially increases HIV risk.. The formative phase of this research enrolled 59 HIV-negative episodic substance using MSM to participate in interviews to inform the adaptation of the Self-Justification Elicitation Instrument (SJEI) used during Personalized Cognitive Counseling (PCC) and to subsequently, pilot the adapted SJEI.. The randomized controlled trial (RCT) phase of this study enrolled 326 ethnically-diverse, HIV-negative episodic SUMSM to receive standard HIV rapid testing plus adapted Personalized Cognitive Risk-reduction Counseling intervention (PCC) or standard HIV counseling and rapid testing only.. Specific Aims:. ...
Substances not on this list require notification under the New Substances Notification Regulations (Chemicals and Polymers) or New Substances Notification Regulations (Organisms) so that health and ecological risks can be assessed before the substance is manufactured or imported into Canada above threshold quantities ...
The substances in this list were identified at the following OSPAR Commission meetings: OSPAR/MMC 1998: Agreement reference number 1998-16 (Annex 2 to the OSPAR Strategy with regard to Hazardous Substances); When identifying the substances or groups of substances, OSPAR/MMC 1998 has not allocated CAS and EINECS registration numbers. Background documents adopted by the OSPAR Commission for these substances or groups of substances may indicate which substances have been addressed so far by OSPAR) OSPAR 2000: Agreement reference number 2000-10; OSPAR 2001: Agreement reference number 2001-2; OSPAR 2002: Agreement reference number 2002-18 The identification of these substances and the consequent action required is explained in § 7.6 of the OSPAR 2002 Summary Record. In brief, these substances have rankings in terms of persistency, liability to bioaccumulate and toxicity which are of equal concern as the other substances on this list. However, to the best of OSPARs knowledge, on the basis of ...
P-positive cells are then added to all tubes. One tube from each set is kept in an ice bath for 90 minutes (1A, 2A, 3A). Another tube from each set is kept at 37°C for 90 minutes (1B, 2B, 3B). The last tube from each set is put in an ice bath for 30 minutes and then incubated at 37°C for 60 minutes (1C, 2C, 3C ...
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter - receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more. ...
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter - receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more. ...
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter - receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more. ...
Toxicity is the capability of a chemical to produce injury. Almost any substance is toxic when taken in doses exceeding tolerable limits. Hazard is the probability that an injury will occur or rather the prospect that an individual will receive a toxic dose. The effects of a toxic chemical may be qualified into several categories. Local toxicity is the effect a substance has on the body tissues at the point of contact. Acute toxicity is the effect a substance has after only one or a few short, relatively large exposures.
Substances on the list still require notification under the New Substances Notification Regulations (Chemicals and Polymers) so that health and ecological risks can be assessed before the substance is manufactured or imported into Canada above threshold quantities, however they are subject to fewer information requirements and higher thresholds for reporting ...
Herbal remedies and other substances. See also: Phytotherapy. Substance based practices use substances found in nature such as ... "Biology"-based practices: Use substances found in nature such as herbs, foods, vitamins, and other natural substances. (Note ... A belief that a substance that causes the symptoms of a disease in healthy people cures similar symptoms in sick people.[n 8] ... Ayurveda believes in the existence of three elemental substances, the doshas (called Vata, Pitta and Kapha), and states that a ...
Other substances - deliberate[edit]. Recreational use[edit]. Legal - helium, nitrous oxide ("laughing gas") ... Other substances - accidental[edit]. Examples of accidental inhalation includes inhalation of water (e.g. in drowning), smoke, ... Various specialized investigations use the inhalation of known substances for diagnostic purposes. Examples include pulmonary ... food, vomitus and less common foreign substances[1] (e.g. tooth fragments, coins, batteries, small toy parts, needles). ...
Examples of flammable substances[edit]. Flammable substances include, but are not limited to: *Gasoline - Petrol / a ... Any solid substance complying with either of two sets of passing criteria listed in Section 8 of ASTM E 136 when the substance ... Fire resistant substances are preferred for building materials and furnishings. Code definitions[edit]. For an Authority Having ... Substances with low combustibility may be selected for construction where the fire risk must be reduced, such as apartment ...
Substance abuse / Substance use disorder / Substance-related disorders. *Physical dependence / Psychological dependence / ... F19) multiple drug use and use of other psychoactive substances (F20-F29) Schizophrenia, schizotypal and delusional disorders[ ... F10-F19) Mental and behavioural disorders due to psychoactive substance use[edit]. *Note: the following conditions are subtypes ... Substance F1x.0 F1x.1 F1x.2 F1x.3 F1x.4 F1x.5 F1x.6 F1x.7 ... Psychoactive substances, substance abuse and substance-related ...
Substance Dualism Under-covered?[edit]. For such an important topic in philosophy, not only in epistemology but in philosophy ... This position has been labelled bundle dualism, and it is a special case of a general bundle theory of substance, according to ... Substance dualism is contrasted with all forms of materialism, but property dualism may be considered a form of emergent ... To be clear, this is as a reply on behalf of substance dualism. I'm not trying to advocate my own view (that shall remain ...
Substance abuse[edit]. Another of the many issues that could lead to a couple's divorce is substance abuse.[9] There is a noted ... Other grounds for divorce may include alcohol or substance abuse and impotency, infertility or homosexuality of the other party ... the same holds true in cases where a member of the couple feels uncomfortable with the other's overuse of controlled substances ...
Exogenous substances (metabolic ataxia)[edit]. Exogenous substances that cause ataxia mainly do so because they have a ...
Selected substances[edit]. In the University of Queensland pitch drop experiment, pitch has been dripping slowly through a ... Certain substances of variable composition or with non-Newtonian behavior are not assigned precise values, since in these cases ... Observed values of viscosity vary over several orders of magnitude, even for common substances (see the order of magnitude ... The following table illustrates the range of viscosity values observed in common substances. Unless otherwise noted, a ...
... for another substance use disorder.[60] People with both GAD and a substance use disorder also have a higher lifetime ... or psychoactive substance-related disorder (F1), such as excess consumption of amphetamine-like substances, or withdrawal from ... Substance-induced[edit]. Long-term use of benzodiazepines can worsen underlying anxiety,[15][16] with evidence that reduction ... GAD and substance use disorders[edit]. Those with GAD have a lifetime comorbidity prevalence of 30% to 35% with alcohol use ...
Substance related disorders[edit]. Anhedonia is common in people who are dependent upon a wide variety of drugs, including ... Garfield, JB; Lubman, DI; Yücel, M (January 2014). "Anhedonia in substance use disorders: a systematic review of its nature, ... substance related disorders, psychotic disorders, and personality disorders, where it is defined by either a reduced ability to ...
Toxic substances[edit]. Drinking water is often a medium through which harmful toxins travel. Studies have shown that heavy ... Toxic substances[edit]. Further information: Developmental toxicity, Drugs in pregnancy, and Environmental toxins and fetal ... Substances whose toxicity can cause congenital disorders are called teratogens, and include certain pharmaceutical and ... Alliance, Genetic; Health, District of Columbia Department of (2010-02-17). Teratogens/Prenatal Substance Abuse. Genetic ...
For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of ... Chemicals versus chemical substances[edit]. While the term chemical substance is a precise technical term that is synonymous ... Chemical substances are often called 'pure' to set them apart from mixtures. A common example of a chemical substance is pure ... All compounds are substances, but not all substances are compounds. A chemical compound can be either atoms bonded together in ...
Removal of ions and other dissolved substances. Ultrafiltration membranes use polymer membranes with chemically formed ... However no filtration can remove substances that are actually dissolved in the water such as phosphates, nitrates and heavy ... microscopic pores that can be used to filter out dissolved substances avoiding the use of coagulants. The type of membrane ...
Vasoactive substances[edit]. Many pathways are involved in the abnormal proliferation and contraction of the smooth muscle ...
The melting point of a pure substance is always higher and has a smaller range than the melting point of an impure substance or ... "J10 Heat: Change of aggregate state of substances through change of heat content: Change of aggregate state of substances and ... The melting point (or, rarely, liquefaction point) of a substance is the temperature at which it changes state from solid to ... For most substances, melting and freezing points are approximately equal. For example, the melting point and freezing point of ...
Antidotes and other substances used in poisonings[edit]. Nonspecific[edit]. *Charcoal, activated ... Medicines for disorders due to psychoactive substance use[edit]. *Nicotine replacement therapy ...
By constituents or substances[edit]. Aluminum, iron and other metals[edit]. Further information: Aluminum § Health concerns ...
"Controlled Substances found in research and chemical suppliers collections" (PDF).. *^ "The Misuse of Drugs Regulations 2001". ... "Convention against the Illicit Traffic in Narcotic Drugs and Psychotropic Substances, 1988, United Nations Office on Drugs and ... The lists of substances within each class can be amended by order, so the Home Secretary can list new drugs and upgrade, ... Use of Controlled Substances for Research[edit]. A common misunderstanding amongst researchers is that most national laws ( ...
Performance-enhancing substances, also known as performance-enhancing drugs (PED),[1] are substances that are used to improve ... The classifications of substances as performance-enhancing substances are not entirely clear-cut and objective. As in other ... Athletic performance-enhancing substances are sometimes referred to as ergogenic aids.[2][3] Cognitive performance-enhancing ... Ergogenic aids, or athletic performance-enhancing substances, include a number of drugs with various effects on physical ...
"Psychoactive Substances Act 2016".. *^ "Drugs should be moderated, not banned - the new ban will push more users into danger". ... Roadmaps to Regulation: New Psychoactive Substances 2016[edit]. To coincide with the introduction of the UK's Psychoactive ... New Psychoactive Substances."[4] The document surveys the complex and unique world of NPS production and distribution and ... designs and conducts research into the effects of psychoactive substances on the brain, in order to minimise their potential ...
Substances known to be potentially dangerous include Aconitum,[26] secretions from the Asiatic toad,[182] powdered centipede,[ ... Animal substances[edit]. Some animal parts used as medicinals can be considered rather strange such as cows' gallstones,[116] ... Typically, one batch of medicinals is prepared as a decoction of about 9 to 18 substances.[112] Some of these are considered as ... The term "herbal medicine" is somewhat misleading in that, while plant elements are by far the most commonly used substances in ...
Substance abuse. Tiller struggled with substance abuse, which came to a head in 1984 when he was arrested for driving under the ...
Amphoteric substances can do either. Just like a double agent can act as an ally or an enemy, an amphoteric substance can act ... In chemistry, an amphoteric substance is a substance that has the ability to act either as an acid or a base. Remember that ... A common example of an amphiprotic substance is the hydrogen carbonate ion, which can act as a base: HCO3− + H3O+ → H2CO3 + H2O ... Not all amphoteric substances are amphiprotic[edit]. Although an amphiprotic species must be amphoteric, the converse is not ...
"Substance Abuse Treatment, Prevention, and Policy. 11 (1). doi:10.1186/s13011-015-0046-x.. ... A 2013 study of SRO tenants in the greater DTES found that 95.2% had some form of substance dependence and 74.4% had a mental ... Negative experiences such as family violence, parental substance abuse, sexual and emotional abuse, suicide, divorce, and ... also had substance abuse issues.[52] Between 60% and 70% of mentally ill patients treated at St. Paul's Hospital, the hospital ...
For this reason, one species's reaction to a substance is not a reliable indication of the substance's effects in humans. ... Interaction of other substances[edit]. Naturally occurring compounds may also induce or inhibit CYP activity. For example, ... Also, many substances are bioactivated by CYPs to form their active compounds like clopidogrel. ...
... substances[edit]. Several sizes of button and coin cell with 2 9v batteries as a size comparison. They are all ... Substances found in large quantities include epoxy resins, fiberglass, PCBs, PVC (polyvinyl chlorides), thermosetting plastics ... and computer components contain valuable elements and substances suitable for reclamation, including lead, silver, copper, and ...
Presumptive substance testing[edit]. Presumptive substance tests attempt to identify a suspicious substance, material or ... Substance. Urine. Hair. Blood / Oral Fluid Alcohol 6-24 hours[6] Note: Alcohol tests may measure ethyl glucuronide, which can ... Workplace policies and prevention programs can help change the norms and culture around substance abuse.[citation needed] ... Is better at detecting very recent use of a substance. THC may only be detectable for 2-24 hours in most cases. On site drug ...
Materials, toxic substances, waste[edit]. An electric wire reel reused as a center table in a Rio de Janeiro decoration fair. ... Included here are raw materials, minerals, synthetic chemicals (including hazardous substances), manufactured products, food, ... pesticides and fertilizers to domestic chemicals and hazardous substances.[176] Apart from the build-up of greenhouse gas ...
Substance[edit]. Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. ... Being more direct, it is often faster,[quantify] and it ensures that the substance will risk degradation only by salivary ... In contrast, substances absorbed in the intestines are subject to "first-pass metabolism" in the liver before entering the ... LSD, MDMA, morphine, alprazolam, clonazepam, and many other substances including the psychedelic tryptamines and ...
Part D. Toxic substances[edit]. Some Insulating Materials inserted into (existing) cavity walls can give off toxic fumes. ... Precautions must be taken to stop gases and dangerous substances from previous land use from entering the building and ...
... a brain disease that is manifested by compulsive substance use despite harmful consequence. Learn more at psychiatry.org. ... Impaired control: a craving or strong urge to use the substance; desire or failed attempts to cut down or control substance use ... People with addiction (severe substance use disorder) have an intense focus on using a certain substance(s), such as alcohol or ... Addiction and Substance Use Disorders. What Is Addiction?. Addiction is a complex condition, a brain disease that is manifested ...
More on Specific Substances and Illicit Drugs. "Drug addiction" is a general term that covers a very broad range of substances ... The Substance Abuse and MEntal Health Services Administrations (SAMHSA) National Survey on Substance Abuse and Health states ... The term is often used to discuss the improper use of substances, especially substances that can be used for medical purposes. ... The Diagnostic and Statistical Manual of Mental Disorders (DSM) once referred to substance abuse and substance dependence as ...
All Marketplace insurance plans cover mental health and substance abuse services as an essential health benefit. Learn more ... Substance use disorder (commonly known as substance abuse) treatment. Your specific behavioral health benefits will depend on ... This generally means limits applied to mental health and substance abuse services cant be more restrictive than limits applied ... Marketplace plans must provide certain "parity" protections between mental health and substance abuse benefits on the one hand ...
Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States ... Started or increased substance use to cope with stress or emotions related to COVID-19. 2.36 (1.26-4.42). 0.007. 2.04 (0.92- ... For this survey, substance use was defined as use of "alcohol, legal or illegal drugs, or prescriptions drugs that are taken in ... Started or increased substance use to cope with pandemic-related stress or emotions¶. Seriously considered suicide in past 30 ...
For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of ... Chemicals versus chemical substances[edit]. While the term chemical substance is a precise technical term that is synonymous ... Chemical substances are often called pure to set them apart from mixtures. A common example of a chemical substance is pure ... All compounds are substances, but not all substances are compounds. A chemical compound can be either atoms bonded together in ...
For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of ... A chemical substance[1], also known as a pure substance, is a form of matter that has constant chemical composition and ... Chemicals versus chemical substances[edit]. While the term chemical substance is a precise technical term that is synonymous ... Chemical substances are often called pure to set them apart from mixtures. A common example of a chemical substance is pure ...
Originally developed for the game and film industries, where it is the reference solution for 3D texturing, Substance is now ... Substance is a complete suite with everything artists need to create 3D digital materials. ... SUBSTANCE SOURCE. Your high-end 3D materials library.. Bring pro-quality 3D textures into your projects. With Substance Source ... SUBSTANCE DESIGNER. Heavy-duty 3D texture authoring tools.. The industry standard for creating customised materials, Substance ...
... a steel tube coated with a waxy substance./ ∎ an intoxicating, stimulating, or narcotic chemical or drug, esp. an illegal one. ... The composite substance is a complete substance.. There is another type of complete substance-a simple substance or one that ... Since "qualities cannot be the real essence of … a substance, man does not know what substance is in itself." Substance is an ... Substance and Accident. A substance is always a specific substance in existing reality. Furthermore, every finite existing ...
... *The EU Decision Making Process for Active Substances. *New active substance applications - optional ... Procedures for submission and assessment of confirmatory data following approval of an active substance under Regulation (EC) ...
Substance use touches on many facets of public policy, including health and health care, economic issues, criminal justice, and ... Substance Use. Featured. Substance use touches on many facets of public policy, including health and health care, economic ... Underage Substance Use. Researcher Spotlight. * Daniel Siconolfi. Behavioral and Social Scientist. Dan Siconolfi is a ... Sexual Minority Substance Use Disparities: Bisexual Women at Elevated Risk Relative to Other Sexual Minority Groups. The ...
"Congrats to Donny Deutsch," who "impregnated his ex-girlfriend"! ... Thats the sum and substance of a Page Six item in Rupert ...
Substance use touches on many facets of public policy, including health and health care, economic issues, criminal justice, and ... Substance Use. Featured. Substance use touches on many facets of public policy, including health and health care, economic ... Veterans with Both Substance Use and Mental Health Disorders Need Integrated Treatment. Co-occurring substance use and mental ... Adoption of Telemedicine Services by Substance Abuse Treatment Facilities in the U.S.. Telemedicine for treating Substance use ...
Substance Abuse During Pregnancyplus icon *Prescription Opioid Pain Reliever Use During Pregnancy ... Although the aerosol of e-cigarettes generally has fewer harmful substances than cigarette smoke, e-cigarettes and other ...
Substance Abuse and Mental Health Services Administration - SAMHSA. U.S. Department of Health and Human Services ...
ground substance* The amorphous, transparent, extracellular organic material, found in connective tissue [1], which acts as a ... ground substance The matrix of connective tissue, in which various cells and fibres are embedded. The ground substance of ... ground substance (grownd) n. see connective tissue. Cite this article Pick a style below, and copy the text for your ... ground substance A Dictionary of Zoology © A Dictionary of Zoology 1999, originally published by Oxford University Press 1999. ...
Substance Abuse see Alcohol Use Disorder (AUD); Drug Use and Addiction; Drugs and Young People ...
... The UK has left the EU, new rules from January 2021. The transition period after ... Since this substance is harmful to fish or other aquatic life surface waters or ditches must not be contaminated with chemical ... This substance must only be used by operators who are suitably trained and competent to carry out this work. ... However, engineering controls may replace personal protective equipment if a Control of Substances Hazardous to Health (COSHH) ...
... by Gregory Bateson. Let me say that it is an extraordinary honor to be here tonight, and a ... In fact, this is the same old dichotomy between mind and substance.. ... Pythagoras stood for inquiry into pattern rather than inquiry into substance.1 That controversy has gone through the ages, and ...
Other articles where Alarm substance is discussed: pheromone: …been shown to release a chemical from specialized epidermal ... In ostariophysan: Alarm substances. In 1938 Austrian biologist Karl von Frisch introduced an injured minnow (Phoxinus) into a ... By experimentation he demonstrated that a chemical substance released from the lacerated skin… ...
Learn about the causes of substance abuse disorders as well as substance abuse counseling, testing, and prevention. ... Recognize drug addiction and signs of substance abuse. ... Substance Abuse and Addiction. Substance Abuse and Addiction ... Substance Abuse and Addiction Perspective. * AAAP 2018 Read clinically focused news coverage of key developments from AAAP 2018 ...
Of the secondary substances the species is more a substance than the genus, since it is nearer to the primary substance. For if ... secondary substance. Thus Fido the dog is a primary substance-an individual-but dog or doghood is the secondary substance or ... 3.5 Substance and teleology. There is one mark of substance which was important to Aristotle which we have not discussed. This ... 2.1 Substance before Aristotle. Many of the pre-socratic philosophers in fact had a concept of substance rather like that above ...
About Style & Substance William Power and Jennifer Hicks, the stylebook editors at The Wall Street Journal, have compiled the ... monthly bulletin Style & Substance since August 2013. Bill is also an editor and writer in the Journal Reports group, ...
... and treatment of co-occurring bipolar and substance-use disorders, highlighting areas in need of further exploration. ... Bipolar Disorder and Substance Abuse. There is a growing body of literature exploring the interface between bipolar disorder ... There is also a compelling body of evidence that substance use is associated with the development of bipolar disorder for some ... Although patients often claim that they use alcohol or drugs because of mood problems, most evidence indicates that substance ...
Substance use is the continued use of alcohol, illegal drugs, or the misuse of prescription or over-the-counter drugs with ... Substance use is the continued use of alcohol, illegal drugs, or the misuse of prescription or over-the-counter drugs with ... Substance-related and addictive disorders. In: American Psychiatric Association. Diagnostic and Statistical Manual of Mental ...
Substance-related disorders are diagnosed when the use of any substance, whether recreational or prescribed, becomes excessive ... Recent estimates indicate that nearly 21 million adults in the United States have a substance-related addictive disorder. ... Substance-related disorders are generally divided into two groups: substance-induced disorders and substance-use disorders. ... All substance-use disorders are characterized by the continued use of substances despite their causing significant problems in ...
Any substance that lowers the freezing point of water, protecting a system from the ill effects of ice formation. Antifreezes ... Antifreeze, Any substance that lowers the freezing point of water, protecting a system from the ill effects of ice formation. ...
The use, possession or distribution of a substance that is designated as a controlled substance according to these laws is ... Distribution, or intent to distribute, a controlled substance in violation of University policy or federal, state, or local law ... the nature of the substance involved, the amount of the alcohol/substance involved, the disruption to the community, the actual ... 1. Regarding Illicit Substances. The unlawful possession, use, or distribution of illicit drugs and alcohol in New York State ...
Substance Abuse Education * Emergency Response Bomb Threats Criminal Activity Earthquake Explosion/Fire Medical Emergency ... Substance Abuse Policy Sexual Assault/Sexual Harassment Policy Presentation Request Form Campus Free Speech Guidelines ... Forms and Policy Incident Reporting Crime Definitions Substance Abuse Policy Sexual Assault/Sexual Harassment Policy ... These programs have been designed to discourage the use of illicit substances and to educate students on the merits of legal ...
Best Practices: Substance Use Disorder Treatment for Adolescents Angela L. Colistra, Charles E. Crite, Jr., James E. Campbell, ... A Review of the Research on the Relationship Between Substance Abuse and a History of Exposure to Trauma Debbie C. Sturm ... "We Thought Youd Just Tell Us Dont Do Drugs": A Collaborative Substance Use Intervention Program for College Athletic Teams ... Determining the Impact of a Comprehensive Substance Assessment on Problem Recognition, Ambivalence, and Taking Steps Jane ...
Schedule V Controlled Substances. Substances in this schedule have a low potential for abuse relative to substances listed in ... Schedule IV Controlled Substances. Substances in this schedule have a low potential for abuse relative to substances in ... A substance (not included on these lists) may also be regulated as a controlled substance analogue. A controlled substance ... Drugs and other substances that are considered controlled substances under the Controlled Substances Act (CSA) are divided into ...
  • The objective of this study is to test for differences in the prevalence of a range of substance use behaviors and disorders across LGBT individuals of the same gender using a nationally representative sample of adults. (rand.org)
  • There is a growing body of literature exploring the interface between bipolar disorder and substance use disorders (SUDs). (medscape.com)
  • [ 4 ] It is possible that substance abuse can "unmask" an affective disorder in genetically vulnerable individuals due to shared pathophysiology in neurotransmitter systems or adaptations in signaling pathways common to both disorders. (medscape.com)
  • Substance-related and addictive disorders. (medlineplus.gov)
  • This guideline is intended to increase the knowledge and comfort level of health care providers caring for pregnant women who have substance use disorders. (nih.gov)
  • The Act notes the importance of addressing substance use disorders as part of our efforts to effectively engage the nation's mental health challenges. (huffingtonpost.com)
  • Biological Psychiatry is now publishing an article in which researchers evaluated and identified childhood risk factors for the development of future substance use disorders (SUD). (elsevier.com)
  • Dr. Hill commented that these results are important "in showing that risk markers for alcohol dependence and other substance use disorders can be identified long before individuals develop symptoms of these disorders. (elsevier.com)
  • In addition, uncovering these childhood risk markers aids in the search for genes associated with the development of substance use disorders. (elsevier.com)
  • This group's purpose is to study substance use disorders and substance abuse. (datehookup.com)
  • The fifth edition of The Diagnostic and Statistical Manual Disorder s (DSM-5), a manual used by clinicians that contains descriptions and symptoms of all mental disorders classified by the American Psychiatric Association (APA), defines a substance use disorder as a problematic pattern of use of an intoxicating substance leading to significant impairment or distress. (wisconsin.gov)
  • Substance use disorders are defined as mild, moderate, or severe, with the level of severity determined by the individual's symptoms. (wisconsin.gov)
  • Get the facts on the most common substance use disorders from the Substance Abuse and Mental Health Services Administration (SAMHSA). (wisconsin.gov)
  • The term "dual diagnosis" is used increasingly in psychiatric practice to describe this combination of severe mental illness (mainly psychotic disorders) and substance misuse. (bmj.com)
  • 5 We prefer the term "comorbidity" (the simultaneous presence of two or more disorders), though even this may fail to capture potential causal interactions between psychosis and substance misuse. (bmj.com)
  • Whether there is any causal relation between substance misuse and psychotic disorders remains controversial. (bmj.com)
  • People who suffer from substance-related disorders often experience physical and/or psychological dependence and develop problems which affect them socially (e.g., friends withdraw), personally (e.g., relationships breakdown), and at school/work (e.g., miss an exam or deadline). (queensu.ca)
  • It is also very common for someone who suffers from a substance-related disorders to experience other mental health problems such as anxiety or depression as well. (queensu.ca)
  • Mental health disorders and substance use disorders are common health issues. (therecoveryvillage.com)
  • When a person is diagnosed with both a mental illness and a substance use disorder , they are said to have co-occurring disorders. (therecoveryvillage.com)
  • The symptoms of co-occurring disorders are similar to the symptoms of mental health and substance use disorders, but they occur in the same person. (therecoveryvillage.com)
  • There are several different kinds of mental health disorders that commonly co-occur with substance use disorders. (therecoveryvillage.com)
  • Mood disorders and substance abuse disorders are commonly co-diagnosed. (therecoveryvillage.com)
  • In many cases, patients with co-occurring substance use and mood disorders have more severe symptoms than either disorder alone. (therecoveryvillage.com)
  • Anxiety and substance abuse are also commonly diagnosed and are among the most common co-occurring disorders. (therecoveryvillage.com)
  • As is the case with mood disorders, substance abuse and anxiety disorders tend to be more severe in a person that is co-diagnosed than a person that has either one of the disorders alone. (therecoveryvillage.com)
  • However, it is less common for anxiety disorders to be substance-induced than mood disorders. (therecoveryvillage.com)
  • People with anxiety disorders may use substances to self-medicate and relieve their anxiety symptoms, which can lead to substance abuse. (therecoveryvillage.com)
  • Behavioral health is used to include both psychiatric and substance use disorders. (aha.org)
  • People with addiction (severe substance use disorder) have an intense focus on using a certain substance(s), such as alcohol or drugs, to the point that it takes over their life. (psychiatry.org)
  • The America​n Academy of Pediatrics (AAP) has developed the Substance Use Screening and Intervention Implementation Guide​ to help pediatricians incorporate screening, brief intervention, and referral to treatment (SBIRT) for use of alcohol, tobacco, marijuana, and other drugs among adolescent patients. (aap.org)
  • Alcohol, marijuana, and tobacco are substances most commonly used by adolescents. (cdc.gov)
  • Although patients often claim that they use alcohol or drugs because of mood problems, most evidence indicates that substance use worsens mood symptoms, and there is little evidence to support the self-medication hypothesis. (medscape.com)
  • Substance use is the continued use of alcohol, illegal drugs, or the misuse of prescription or over-the-counter drugs with negative consequences. (medlineplus.gov)
  • New York University's policies on substance abuse and on alcoholic beverages are set out below, along with related information regarding University sanctions for violation of these policies, criminal sanctions for the illegal possession or distribution of drugs and alcohol, the health risks associated with drugs and alcohol, and places to obtain help concerning the use and abuse of alcohol and illicit drugs. (nyu.edu)
  • NYU is committed to creating and maintaining a campus environment that is free of alcohol and substance abuse. (nyu.edu)
  • People abuse substances such as drugs and alcohol for varied and complicated reasons. (webmd.com)
  • You can get addicted to alcohol , nicotine, sleep and anti- anxiety medications , and other legal substances. (webmd.com)
  • Sixteen percent of those age 12 and older (today that's close to 40 million Americans) currently meet medical criteria for a substance use disorder involving alcohol, nicotine or other drugs -- legal and illegal. (huffingtonpost.com)
  • The article is "Childhood Risk Factors for Young Adult Substance Dependence Outcome in Offspring from Multiplex Alcohol Dependence Families: A Prospective Study" by Shirley Y. Hill, Stuart R. Steinhauer, Jeannette Locke-Wellman, and Richard Ulrich. (elsevier.com)
  • The central purpose of PAWS is to provide alternative, substance-free opportunities during the weekend or other times of high alcohol and other drug consumption. (nyu.edu)
  • The effects of alcohol and substance abuse can be seen in all age groups and in all facets of society. (datehookup.com)
  • The mission of this program is to fund policy research in the hope of reducing the harm caused by alcohol and substance abuse. (datehookup.com)
  • Substance abuse is the overindulgence of alcohol, illegal drugs, over-the-counter drugs etc. (childrens.com)
  • Effective substance abuse treatment includes education and counseling to help your teen deal with the reasons behind his or her use of drugs or alcohol. (childrens.com)
  • Addiction is a complex condition, a brain disease that is manifested by compulsive substance use despite harmful consequence. (psychiatry.org)
  • The recovery process can be hindered when a person denies having a problem and lacks understanding about substance misuse and addiction. (psychiatry.org)
  • By understanding the impact substances have on the body, you can make better decisions for yourself and loved ones who may be struggling with drug addiction. (therecoveryvillage.com)
  • Drug addiction" is a general term that refers to the compulsive need to seek and use substances, in spite of the harmful consequences. (therecoveryvillage.com)
  • Evaluating American Society of Addiction Medicine (ASAM) Dimension Assessment As an Outcome Measure: A Pilot Study With Substance Abusing Adolescents in Two Matched Residential Treatment Centers. (counseling.org)
  • We gobble up this news and discuss it with friends, but do we ever wonder whether the substance use and addiction that seems so ubiquitous in the entertainment industry is really much different from what is happening in our own lives? (huffingtonpost.com)
  • Is the entertainment industry really more imbued with excessive substance use and addiction than our very own communities and families? (huffingtonpost.com)
  • If we were to get serious about confronting this malady, a good place to start would have been the nation's new health law, the Patient Protection and Affordable Care Act and the opportunity it provides to address risky substance use and addiction in the name of a healthy America. (huffingtonpost.com)
  • But to realize this intention in regard to substance use and addiction, we must first understand addiction to be a medical condition worthy of the top doctors researching the best protocols for treatment and of the best talents crafting viable prevention strategies to ward off this avoidable medical and social tragedy. (huffingtonpost.com)
  • The goal of the Mental Health and Substance Abuse Task Force is to increase access to quality mental health and addiction services for children and their families. (in.gov)
  • In response to the article, which goes on to suggest that anti-alcoholism medications will bring addiction recovery into a doctor's office setting, the head of the Substance Abuse Help Group noted, "A medication to fight alcoholism will work on the brain, and it will help people change their immediate behavior, but many will need long-term counseling or behavior therapy to fully rebuild their lives. (prweb.com)
  • It is never too late to get help for a substance abuse addiction. (prweb.com)
  • People with a substance use disorder have distorted thinking, behavior and body functions. (psychiatry.org)
  • A health professional can conduct a formal assessment of symptoms to see if a substance use disorder exists. (psychiatry.org)
  • Even if the problem seems severe, most people with a substance use disorder can benefit from treatment. (psychiatry.org)
  • Marketplace plans can't deny you coverage or charge you more just because you have any pre-existing condition, including mental health and substance use disorder conditions. (healthcare.gov)
  • Marketplace plans can't put yearly or lifetime dollar limits on coverage of any essential health benefit , including mental health and substance use disorder services. (healthcare.gov)
  • The self-medication model posits that individuals with bipolar disorder use substances of abuse to counteract unpleasant affective symptoms. (medscape.com)
  • There is also a compelling body of evidence that substance use is associated with the development of bipolar disorder for some individuals. (medscape.com)
  • Multiple studies have demonstrated a negative impact of substance abuse on clinical outcomes in patients with bipolar disorder. (medscape.com)
  • You may have heard a friend or family member, suffering from Substance Use Disorder, refer to their drug use as a means to "fill a void. (psychcentral.com)
  • It specifies that "mental health and substance use disorder services, including behavioral health treatment" are among the "Essential Health Benefits" required to be offered by Medicaid Plans in the new "Health Benefit Exchanges. (huffingtonpost.com)
  • They found that children with increased body sway and reduced P300 amplitude had an 8-fold increase in their likelihood of developing a substance use disorder by young adulthood, indicating that neurobiological variables are among the most important in predicting outcome. (elsevier.com)
  • When someone is behaving in this way, it may be time for them to talk to a professional about a substance use disorder. (wisconsin.gov)
  • What is a substance use disorder? (wisconsin.gov)
  • Consultation with a professional is needed to diagnosis a substance use disorder. (wisconsin.gov)
  • The Wisconsin Department of Health Services has long supported individuals living with a substance use disorder manage their symptoms and experience the life they envisioned. (wisconsin.gov)
  • Use this online search tool [4] from the Substance Abuse and Mental Health Services Administration to find a substance use disorder treatment program. (wisconsin.gov)
  • Evidence from the United States suggests that half of all patients with schizophrenia also have a substance misuse disorder. (bmj.com)
  • If the enzyme deficiency or activity is weakened due to genetic defects or other reasons, the catalytic reaction of the enzyme may be abnormal, resulting in disorder of the substance metabolism or even disease. (selfgrowth.com)
  • First of all just because you use a substance, whether it's legal or illegal, doesn't mean that you have a disorder. (queensu.ca)
  • While there is no single cause of substance-related problems, some factors put people at an increased risk for developing this type of mental health disorder. (queensu.ca)
  • A co-occurring disorder is defined by the dual diagnosis of a mental health disorder and a substance use disorder in the same person. (therecoveryvillage.com)
  • Only a mental health professional can diagnose a mental health or substance use disorder. (therecoveryvillage.com)
  • It is common to try and treat a substance use disorder first and then address the mood disorder. (therecoveryvillage.com)
  • However, these statistics do not reflect the number of people who have tried illicit drugs, or who have abused illicit substances or prescription medications. (therecoveryvillage.com)
  • Listed chemicals are regulated in order to prevent the illicit manufacture of controlled substances. (csusm.edu)
  • During 2017, we continued with the second phase of the program, where we reviewed and managed a further 17 substances. (akzonobel.com)
  • Chemical substances are often called 'pure' to set them apart from mixtures . (wikipedia.org)
  • In geology , substances of uniform composition are called minerals , while physical mixtures ( aggregates ) of several minerals (different substances) are defined as rocks . (wikipedia.org)
  • In law, "chemical substances" may include both pure substances and mixtures with a defined composition or manufacturing process. (wikipedia.org)
  • Polymers almost always appear as mixtures of molecules of multiple molar masses, each of which could be considered a separate chemical substance. (wikipedia.org)
  • Succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. (cdc.gov)
  • The present invention concerns a flavoring substance-included cellulose, comprising or consisting of cellulose and flavoring substances included in the cellulose, methods for producing such flavoring substance-included celluloses, and mixtures comprising flavoring substance according to the invention. (freepatentsonline.com)
  • and (ii) one or more flavoring substances having a logP ow of greater than 1.0 embedded into voids of the cellulose at a molecular level, (iii) an accompanying substance selected from the group consisting of hemicellulose, lignin, and mixtures thereof, wherein the total quantity of hemicellulose in relation to the total weight of the accompanying substance (iii) is in the range of 70 to 100 wt. (freepatentsonline.com)
  • In CERCLA, it is called the priority list of hazardous substances that will be candidates for toxicological profiles. (cdc.gov)
  • This issue includes a fully revised list of hazardous substances (all substances published in the official German exposure limit lists plus certain other substances that are important in the workplace but lack exposure limits), with methods of determination. (ilo.org)
  • Substance use by adolescents has an enormous impact on their health and well-being. (aap.org)
  • Compared to people in other age groups, adolescents are at the highest risk for experiencing health problems related to substance use (Committee on Substance Use and Prevention, American Academy of Pediatrics, 2015). (aap.org)
  • The guide, Substance Use Screening and Intervention Implementation Guide: No Amount of Substance Use Is Safe for Adolescents Cdc-pdf pdf icon [3 MB] External external icon , provides helpful information for pediatricians to implement substance use screening and brief counseling in their practices. (cdc.gov)
  • This study is aimed at identifying what drives early adolescents (13-16 years) to use substances. (hindawi.com)
  • Drugs and other substances that are considered controlled substances under the Controlled Substances Act (CSA) are divided into five schedules. (usdoj.gov)
  • Performs protocol reviews concerning pre-clinical and clinical protocols submitted for controlled substances and potentially abused drugs. (fda.gov)
  • Controlled substances: Psychotropic drugs and precursors regulated under the Federal Controlled Substances Act and the California Uniform Controlled Substances Act. (csusm.edu)
  • The Agency for Toxic Substances and Disease Registry (ATSDR) , based in Atlanta, Georgia, is a federal public health agency of the U.S. Department of Health and Human Services . (cdc.gov)
  • It should be noted that this priority list is not a list of "most toxic" substances, but rather a prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at NPL sites. (cdc.gov)
  • The chemical-a combination of chlorine and ammonia-has been used increasingly in drinking water disinfection since the EPA set limits for better-known toxic substances that can arise from the use of chlorine, the traditional disinfectant. (nationalgeographic.com)
  • Earth Justice, the United Steelworkers, the Environmental Defense Fund and other public interest groups are suing the Trump administration over two new regulations to address toxic substances. (scienceblogs.com)
  • OxyChem is likely the largest asbestos importer in the U.S. The company is required under the Toxic Substances Control Act (TSCA) to report its asbestos imports to the EPA. (scienceblogs.com)
  • EPA's announcement is the first major milestone established by Congress when it passed sweeping changes earlier this year to the Toxic Substances Control Act. (scienceblogs.com)
  • In 2016 we updated the scoring methodology used in the prioritization process, taking into account recent scientific developments and public concerns over hazardous substances. (akzonobel.com)
  • ATSDR protects communities from harmful health effects related to exposure to natural and man-made hazardous substances. (cdc.gov)
  • CEHPs include information about specific types of exposures to hazardous substances, exposure routes and pathways, health effects, and how to prevent and minimize exposures. (cdc.gov)
  • The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. (cdc.gov)
  • Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. (cdc.gov)
  • Answers are provided to the most frequently asked questions (FAQs) about exposure to hazardous substances found around hazardous waste sites and the effects of exposure on human health. (cdc.gov)
  • Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. (cdc.gov)
  • The listing algorithm prioritizes substances based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure to the substances found at NPL sites. (cdc.gov)
  • Thus, it is possible for substances with low toxicity but high NPL frequency of occurrence and exposure to be on this priority list. (cdc.gov)
  • Meanwhile, several states have expanded their civil child-welfare requirements to include prenatal substance use, so that prenatal drug exposure can provide grounds for terminating parental rights because of child abuse or neglect. (guttmacher.org)
  • This invention relates to a convenient integral or self-contained non-invasive dermal substance collection device easily reversibly attachable to a dermal surface for use in detection, routine monitoring and research in the areas of compliance with therapeutic regimens and exposure to substances of abuse or environmental toxic chemicals or xenobiotics, and investigation of endogenous substances. (google.co.uk)
  • Updated versions of Technical Rules (TRGS) 420 (Process- and substance-specific criteria for reliable long-term maintenance of exposure limits), 512 (Fumigation), 522 (Disinfection of spaces with formaldehyde), 900 (Workplace exposure limits) and 905 (List of substances that are carcinogenic, genotoxic or show reproductive toxicity) are also included in this update. (ilo.org)
  • Substance use touches on many facets of public policy, including health and health care, economic issues, criminal justice, and risk behaviors - particularly among youth. (rand.org)
  • Pediatric care providers play a critical, ongoing role in the lives of their adolescent patients and have a unique opportunity to educate them about the dangers of substance use and to influence their behaviors. (aap.org)
  • Adults who engage in substance abuse may end up losing close relationships with those they care for, losing jobs and careers they have worked hard for, and they may even risk incarceration because of their addictions and behaviors. (datehookup.com)
  • Continuum of Substance Use Behaviors. (elsevier.com)
  • For example, programmes to improve liaison between psychiatric and substance misuse services may appear attractive. (bmj.com)
  • 7 The medical model of psychiatric services, with their recourse to legal compulsion to treat those incapable of making rational health choices, contrasts sharply with the psychosocial orientation of substance misuse services. (bmj.com)
  • Through AHA's Section for Psychiatric and Substance Abuse Services, you can shape the future of access, coverage and delivery of behavioral health. (aha.org)
  • new or updated Technical Rules for Dangerous Substances (TRGS) 300 (safety techniques), 513 and 522 (fumigation with ethylene oxide and/or formaldehyde), 519 (demolition, cleanup or maintenance involving asbestos) and 520 (hazardous waste dumps). (ilo.org)
  • These procedures are found in the Masked Name Regulations and, for those of us that need a little more than legalese, these procedures are also found in subsection 7.2.2.1 in the Guidelines for the Notification and Testing of New Substances (Chemicals and Polymers) . (intertek.com)
  • Listed chemicals (also known as precursor chemicals): Chemicals that may be used to manufacture controlled substances. (csusm.edu)
  • Though great strides have been made in reinventing some chemicals and products, most industries remain dependent on thousands of hazardous substances such as chlorine. (latimes.com)
  • Among 500 potential river basin-specific pollutants which were recently prioritised, triclosan ranks on position 6 of the most problematic substances, based on the Elbe River data alone. (springer.com)
  • To improve awareness and knowledge of problematic substance use in pregnancy and to provide evidence-based recommendations for the management of this challenging clinical issue for all health care providers. (nih.gov)
  • This guideline reviews the use of screening tools, general approach to care, and recommendations for clinical management of problematic substance use in pregnancy. (nih.gov)
  • Evidence-based recommendations for screening and management of problematic substance use during pregnancy and lactation. (nih.gov)
  • Patterns of substance misuse vary considerably, but use as well as dependency may be problematic among people with psychosis. (bmj.com)
  • The objective of this priority list is to rank substances across all NPL hazardous waste sites to provide guidance in selecting which substances will be the subject of toxicological profiles prepared by ATSDR. (cdc.gov)
  • The number of older people (aged over 50) experiencing problems from substance misuse is also growing rapidly, with the numbers receiving treatment expected to treble in the United States and double in Europe by 2020. (bmj.com)
  • Steam and liquid water are two different forms of the same chemical substance, water. (wikipedia.org)
  • A chemical substance is a form of matter having constant chemical composition and characteristic properties. (wikipedia.org)
  • [1] [2] A chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., without breaking chemical bonds . (wikipedia.org)
  • [3] Chemical substances can be simple substances [4] , chemical compounds , or alloys . (wikipedia.org)
  • Other chemical substances commonly encountered in pure form are diamond (carbon), gold , table salt ( sodium chloride ) and refined sugar ( sucrose ). (wikipedia.org)
  • However, in practice, no substance is entirely pure, and chemical purity is specified according to the intended use of the chemical. (wikipedia.org)
  • Chemical substances exist as solids , liquids , gases , or plasma , and may change between these phases of matter with changes in temperature or pressure . (wikipedia.org)
  • Chemical substances may be combined or converted to others by means of chemical reactions . (wikipedia.org)
  • A chemical substance may well be defined as "any material with a definite chemical composition" in an introductory general chemistry textbook. (wikipedia.org)
  • [5] According to this definition a chemical substance can either be a pure chemical element or a pure chemical compound. (wikipedia.org)
  • [6] The chemical substance index published by CAS also includes several alloys of uncertain composition. (wikipedia.org)
  • The concept of a "chemical substance" became firmly established in the late eighteenth century after work by the chemist Joseph Proust on the composition of some pure chemical compounds such as basic copper carbonate . (wikipedia.org)
  • A chemical substance [1] , also known as a pure substance , is a form of matter that has constant chemical composition and characteristic properties. (wikipedia.org)
  • Since this substance is harmful to fish or other aquatic life surface waters or ditches must not be contaminated with chemical or used container. (hse.gov.uk)
  • This list describes the basic or parent chemical and does not describe the salts, isomers and salts of isomers, esters, ethers and derivatives which may also be controlled substances. (usdoj.gov)
  • These lists describe the basic or parent chemical and do not describe the salts, isomers, salts of isomers, esters, ethers, and derivatives which may be controlled substances. (usdoj.gov)
  • If outside parties want to ensure that a compound is not considered a scheduled substance or listed chemical, they should write the DEA, Drug and Chemical Evaluation Section (DRE), Diversion Control Division, 8701 Morrissette Drive, Springfield, Virginia 22152, for an official determination. (usdoj.gov)
  • A dermal substance collection device (DSCD) is described which provides ms for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. (google.co.uk)
  • If a chemical you require for research is classified as a Controlled Substance (CS), you must apply for a DEA license before work can begin. (csusm.edu)
  • For chemical purposes, an element can be defined as a substance that cannot be chemically decomposed into simpler substances. (factmonster.com)
  • The other type of pure substance is a chemical compound. (factmonster.com)
  • Intoxication symptoms are different for each substance. (psychiatry.org)
  • The substance (or a closely related substance) is taken to relieve or avoid withdrawal symptoms. (wisconsin.gov)
  • Physical dependence - occurs when your body becomes so used to a substance that it can only function with it and you experience withdrawal symptoms when you are unable to have it. (queensu.ca)
  • What are the signs and symptoms of Adolescent Substance Abuse? (childrens.com)
  • Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. (cdc.gov)
  • The ATSDR ToxFAQs™ are summaries about hazardous substances developed by the ATSDR Division of Toxicology and Human Health Sciences. (cdc.gov)
  • Each substance on the list is a candidate to become the subject of a toxicological profile prepared by ATSDR. (cdc.gov)
  • Additional information is available from the American Academy of Pediatrics Committee on Substance Use and Prevention . (aap.org)
  • The American Academy of Pediatrics (AAP), through a cooperative agreement with the Centers for Disease Control and Prevention (CDC), developed a guide for implementing substance use screening in pediatric practices to help pediatricians address substance use concerns. (cdc.gov)
  • Page from the American Academy of Pediatrics with information for parents on substance abuse prevention. (datehookup.com)
  • And in order to receive federal child abuse prevention funds, states must require health care providers to notify child protective services when the provider cares for an infant affected by illegal substance use. (guttmacher.org)
  • EPA has established no new regulatory requirements under the Clean Water Act's (CWA) section 311(j)(1)(C) authority for CWA hazardous substances (HS) discharge prevention and containment. (epa.gov)
  • While most prevention programs are aimed at helping young people stay abstinent and to resist peer group pressure, there are few studies that describe the processes which drive the choice of utilizing diverse substances, studies that could help to develop and inform innovative approaches, especially in the education field and dissuasion efforts [ 17 ]. (hindawi.com)
  • Prevention is our most important weapon against adolescent substance abuse. (childrens.com)
  • In the past few months, Charlie Sheen, David Arquette, and Jaime Pressly top the list of celebrities garnering recent headlines regarding their struggles with addictive substances. (huffingtonpost.com)
  • In this day and age of 24/7 media coverage, we become instant voyeurs, as celebrities, sometimes known more for their use of addictive substances than their talent, enter an all too frequent revolving door of rehabilitation, coming and going from one program to another. (huffingtonpost.com)
  • Inpatient treatment uses a similar approach, but also often includes medical supervision to help a teen withdraw from the addictive substance. (childrens.com)
  • Substances are placed in their respective schedules based on whether they have a currently accepted medical use in treatment in the United States, their relative abuse potential, and likelihood of causing dependence when abused. (usdoj.gov)
  • Serves as the FDA and CDER liaison with DEA, the White House Office of National Drug Control Policy (ONDCP), the Substance Abuse and Mental Health Services Administration (SAMHSA), and the National Institute on Drug Abuse (NIDA) regarding all matters of drug scheduling and the identification of new trends in and risks related to abuse and dependence. (fda.gov)
  • There aren't any credible measures to calculate the actual rates of substance use and dependence among celebrities. (huffingtonpost.com)
  • Models of Substance Dependence. (elsevier.com)
  • Causal Factors of Substance Abuse and Dependence. (elsevier.com)
  • Special Issues of Substance Dependence. (elsevier.com)
  • Substance Abuse-Dependence Continuum of Care Services. (elsevier.com)
  • Psychological dependence - occurs when the substance becomes such a central part of your life that it plays a big role in your thoughts, feelings, and behaviours. (queensu.ca)
  • The most well-known of these substances is benzo[a]pyrene (BaP) due to its high toxicity and its facile identification. (eurekalert.org)
  • Because benzo[a]pyrene is highly carcinogenic, European directives specify a limit for the maximum amount of this substance in drinking water (10 ng/L for BaP). (eurekalert.org)
  • Parents can help by talking to their teen's pediatrician about screening for substance use. (cdc.gov)
  • The AAP recommends screening for substance use in children, starting at 9 years of age. (cdc.gov)
  • When testing for substance use is clinically indicated, urine drug screening is the preferred method. (nih.gov)
  • Legal Issues Associated with Screening and Assessing Adolescent Substance Use. (elsevier.com)
  • The present invention relates to a product comprising tooth whitening substance which comprises a high concentration of water, a peroxide, a gelling agent, and carrier materials. (google.com)
  • The present invention also relates to a method of storage of a tooth whitening substance and a method producing a stable thin layer of tooth whitening substance on a strip of material. (google.com)
  • The present invention relates generally to substance delivery systems, and particularly to ultrasonically enhanced substance delivery devices. (google.com)
  • The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover. (google.co.uk)
  • Although the aerosol of e-cigarettes generally has fewer harmful substances than cigarette smoke, e-cigarettes and other products containing nicotine are not safe to use during pregnancy. (cdc.gov)
  • Since the late 1980s, policymakers have debated the question of how society should deal with the problem of women's substance use during pregnancy. (guttmacher.org)
  • The Supreme Courts in Alabama and South Carolina have upheld convictions ruling that a woman's substance use in pregnancy constitutes criminal child abuse. (guttmacher.org)
  • 23 states and the District of Columbia consider substance use during pregnancy to be child abuse under civil child-welfare statutes, and 3 consider it grounds for civil commitment. (guttmacher.org)
  • Both of these concepts-substance abuse and psychopathology-are not all-or-none phenomena, like cancer or pregnancy. (springer.com)
  • Resources, tools, and information for providers and their patients regarding substance abuse during pregnancy. (acog.org)
  • What is the difference in addictions to specific substances? (therecoveryvillage.com)
  • Early substance abuse increases an adolescent's chance of developing addictions and other serious problems. (childrens.com)
  • Substance abuse treatment resources and information for parents. (datehookup.com)
  • In this paper we estimate the effects of expanding access to substance-abuse treatment on local crime. (nber.org)
  • We do so using an identification strategy that leverages variation driven by substance-abuse-treatment facility openings and closings measured at the county level. (nber.org)
  • The results indicate that substance-abuse-treatment facilities reduce both violent and financially motivated crimes in an area, and that the effects are particularly pronounced for relatively serious crimes. (nber.org)
  • Outpatient substance abuse treatment involves attending classes or counseling sessions. (childrens.com)
  • Compounds are pure substances made up of two or more elements in defined proportions. (factmonster.com)
  • All Marketplace plans cover mental health and substance abuse services as essential health benefits. (healthcare.gov)
  • Marketplace plans must provide certain "parity" protections between mental health and substance abuse benefits on the one hand, and medical and surgical benefits on the other. (healthcare.gov)
  • This generally means limits applied to mental health and substance abuse services can't be more restrictive than limits applied to medical and surgical services. (healthcare.gov)
  • Substance use by teens can have a big impact on their health and well-being. (cdc.gov)
  • However, engineering controls may replace personal protective equipment if a Control of Substances Hazardous to Health ( COSHH ) assessment shows they provide an equal or higher standard of protection. (hse.gov.uk)
  • Industries with the highest published employment and wages for Mental Health and Substance Abuse Social Workers are provided. (bls.gov)
  • For a list of all industries with employment in Mental Health and Substance Abuse Social Workers, see the Create Customized Tables function. (bls.gov)
  • Health care providers should employ a flexible approach to the care of women who have substance use problems, and they should encourage the use of all available community resources. (nih.gov)
  • Substance abuse can create an illusory sense of well-being, but in the end it severely damages physical, psychological, and spiritual health. (healthy.net)
  • In other words, individuals with substance use conditions often have a mental health condition at the same time, and vice versa. (wisconsin.gov)
  • The purchase, use, storage, and disposal of Controlled Substances is regulated by the United States Department of Justice, Drug Enforcement Administration (DEA) Controlled Substances Act (21 CFR 1300), and the Massachusetts Department of Public Health regulation (105 CMR 700). (mbl.edu)
  • The Marine Biological Laboratory (MBL) Attending Veterinarian (AV) currently has a PRACTITIONER Federal DEA Registration and a Controlled Substances (Schedules II-VI) Registration issued by the Massachusetts Department of Public Health, Drug Control Program. (mbl.edu)
  • This month serves as a reminder that children are vulnerable to harmful substances in the environment. (cdc.gov)
  • Illegal substances' is nearer to one of the philosophical uses, but not the main one. (stanford.edu)
  • 3. To set forth the standards and regulations associated with the possession, consumption, service and distribution of illegal controlled substances at the University. (nyu.edu)
  • Substance-Related Assessment Inventories. (elsevier.com)
  • Conceptual Assessment of Substance Abuse. (elsevier.com)
  • Factors Indicating a Need for Adolescent Substance Use Assessment. (elsevier.com)
  • [ 8 , 9 ] Substance abuse is associated with more mixed depressive-manic episodes, [ 10 ] increased frequency of mood swings, and more hospitalizations in bipolar patients currently abusing substances than in bipolar patients without SUDs. (medscape.com)
  • [ 13 ] More recently, a multicenter study found that bipolar patients with comorbid SUDs have lower recovery status, poorer role functioning, and lower quality of life than bipolar patients without SUDs, whether their substance abuse is current or past. (medscape.com)
  • The current list of controlled substances can be found in section 1308 of the most recent issue of Title 21 Code of Federal Regulations (CFR) Part 1300 to end (21 CFR §1308) and the final rules which were published in the Federal Register subsequent to the issuance of the CFR. (usdoj.gov)
  • Yes, there is a fee associated with masking under the New Substances Fees Regulations of about $600 CAD. (intertek.com)
  • Specific Substance Class Treatment Considerations Associated with Continuum of Care. (elsevier.com)
  • A listing of sites with surveys, assessments, and trends concerning substance abuse. (datehookup.com)
  • Finally, the earlier teens start using substances, the greater their chances of continuing to use substances and developing substance use problems later in life. (cdc.gov)
  • Comparing the psychopathology of substance abuse across cultural boundaries involves certain problems of definition and research methodology. (springer.com)
  • Continued use of the substance despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of its use. (wisconsin.gov)