Substance p. Medical search

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.

A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.

Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.

An oligopeptide isolated from the skin of Physalaemus fuscumaculatus, a South American frog. It is a typical kinin, resembling SUBSTANCE P in structure and action and has been proposed as a sialagogue, antihypertensive, and vasodilator.

Cell surface proteins that bind TACHYKININS with high affinity and trigger intracellular changes influencing the behavior of cells. Three classes of tachykinin receptors have been characterized, the NK-1; NK-2; and NK-3; which prefer, respectively, SUBSTANCE P; NEUROKININ A; and NEUROKININ B.

A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364)

A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.

Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

Disorders related to substance abuse.

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. Neurotransmitter is used here in its most general sense, including not only messengers that act to regulate ion channels, but also those which act on second messenger systems and those which may act at a distance from their release sites. Included are receptors for neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not located at synapses.

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.

Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.

A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).

A class of cell surface receptors for tachykinins that prefers neurokinin B (neurokinin beta, neuromedin K) over other tachykinins. Neurokinin-3 (NK-3) receptors have been cloned and are members of the G-protein coupled receptor superfamily. They have been found in the central nervous system and in peripheral tissues.

A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.

Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.

Dodecapeptide tachykinin found in the central nervous system of the amphibian Kassina senegalensis. It is similar in structure and action to other tachykinins, but is especially effective in contracting smooth muscle tissue and stimulating the micturition reflex.

Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

A family of hexahydropyridines.

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.

Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.

A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.

The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.

Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Use of electric potential or currents to elicit biological responses.

The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.

The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.

The co-existence of a substance abuse disorder with a psychiatric disorder. The diagnostic principle is based on the fact that it has been found often that chemically dependent patients also have psychiatric problems of various degrees of severity.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

Introduction of therapeutic agents into the spinal region using a needle and syringe.

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.

Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

A potent mast cell degranulator. It is involved in histamine release.

An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Elements of limited time intervals, contributing to particular results or situations.

A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.

The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.

The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity.

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.

The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.

Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.

One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38)

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

The excessive use of marijuana with associated psychological symptoms and impairment in social or occupational functioning.

Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.

The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network. (1/2566)

Paired intracellular recordings have been used to examine the activity-dependent plasticity and neuromodulator-induced metaplasticity of synaptic inputs from identified inhibitory and excitatory interneurons in the lamprey spinal cord. Trains of spikes at 5-20 Hz were used to mimic the frequency of spiking that occurs in network interneurons during NMDA or brainstem-evoked locomotor activity. Inputs from inhibitory and excitatory interneurons exhibited similar activity-dependent changes, with synaptic depression developing during the spike train. The level of depression reached was greater with lower stimulation frequencies. Significant activity-dependent depression of inputs from excitatory interneurons and inhibitory crossed caudal interneurons, which are central elements in the patterning of network activity, usually developed between the fifth and tenth spikes in the train. Because these interneurons typically fire bursts of up to five spikes during locomotor activity, this activity-dependent plasticity will presumably not contribute to the patterning of network activity. However, in the presence of the neuromodulators substance P and 5-HT, significant activity-dependent metaplasticity of these inputs developed over the first five spikes in the train. Substance P induced significant activity-dependent depression of inhibitory but potentiation of excitatory interneuron inputs, whereas 5-HT induced significant activity-dependent potentiation of both inhibitory and excitatory interneuron inputs. Because these metaplastic effects are consistent with the substance P and 5-HT-induced modulation of the network output, activity-dependent metaplasticity could be a potential mechanism underlying the coordination and modulation of rhythmic network activity. (+info)

Molecular dynamics study of substance P peptides in a biphasic membrane mimic. (2/2566)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in a TIP3P water/CCl4 biphasic solvent system as a mimic for the water-membrane system. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) in the equilibration stage of the simulation. The starting orientation/position of the peptides for the MD simulation was either parallel to the water/CCl4 interface or in a perpendicular/insertion mode. In both cases the peptides equilibrated and adopted a near-parallel orientation within approximately 250 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained in the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbone of nearly all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions with the hydrophobic phase come from the hydrophobic interactions of the side chains of Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, and Phe-7, Leu-10, Met-11 and, to a lesser extent, Tyr-8 in SP-Y8. Concerted conformational transitions took place in the time frame of hundreds of picoseconds. The concertedness of the transition was due to the tendency of the peptide to maintain the necessary secondary structure to position the peptide properly with respect to the water/CCl4 interface. (+info)

Molecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelle. (3/2566)

Two neuropeptides, substance P (SP) and SP-tyrosine-8 (SP-Y8), have been studied by molecular dynamics (MD) simulation in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements (NOE) were incorporated in the restrained MD (RMD) during the equilibration stage of the simulation. It was shown that when SP-Y8 was initially placed in an insertion (perpendicular) configuration, the peptide equilibrated to a surface-bound (parallel) configuration in approximately 450 ps. After equilibration, the conformation and orientation of the peptides, the solvation of both the backbone and the side chain of the residues, hydrogen bonding, and the dynamics of the peptides were analyzed from trajectories obtained from the RMD or the subsequent free MD (where the NOE restraints were removed). These analyses showed that the peptide backbones of all residues are either solvated by water or are hydrogen-bonded. This is seen to be an important factor against the insertion mode of interaction. Most of the interactions come from the hydrophobic interaction between the side chains of Lys-3, Pro-4, Phe-7, Phe-8, Leu-10, and Met-11 for SP, from Lys-3, Phe-7, Leu-10, and Met-11 in SP-Y8, and the micellar interior. Significant interactions, electrostatic and hydrogen bonding, between the N-terminal residues, Arg-Pro-Lys, and the micellar headgroups were observed. These latter interactions served to affect both the structure and, especially, the flexibility, of the N-terminus. The results from simulation of the same peptides in a water/CCl4 biphasic cell were compared with the results of the present study, and the validity of using the biphasic system as an approximation for peptide-micelle or peptide-bilayer systems is discussed. (+info)

Two affinities for a single antagonist at the neuronal NK1 tachykinin receptor: evidence from quantitation of receptor endocytosis. (4/2566)

1. In smooth muscle contractility assays, many NK1 receptor (NK1r) antagonists inhibit responses to the neurotransmitter, substance P (SP), and its analogue, septide, with markedly different potency, leading to the proposal that there is a septide-preferring receptor related to the NK1r. 2. We used fluorescence immunohistochemistry and confocal microscopy to visualize agonist-induced NK1r endocytosis and analyse agonist/antagonist interactions at native NK1r in neurons of the myenteric plexus of guinea-pig ileum. 3. SP and septide gave sigmoid log concentration-response curves and were equipotent in inducing NK1r endocytosis. 4. The NK1r antagonists, CP-99994 (2S,3S)-3-(2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride and MEN-10581, cyclo(Leu,[CH2NH]Lys(benzyloxycarbonyl)-Gln-Trp-Phe-betaAla) were both more potent in inhibiting endocytosis (50 x and 8 x greater respectively) against septide than against SP. 5. The results suggest that SP and septide interact differently with the NK1r, and that a single antagonist can exhibit different affinities at a single NK1r population, depending on the agonist with which it competes. Thus it may not be necessary to posit a separate septide-preferring tachykinin receptor. (+info)

Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. (5/2566)

To assess the role of lung sensory C fibers during and after inhalation of 1 part/million ozone for 8 h, we compared breathing pattern responses and epithelial injury-inflammation-repair in rats depleted of C fibers by systemic administration of capsaicin as neonates and in vehicle-treated control animals. Capsaicin-treated rats did not develop ozone-induced rapid, shallow breathing. Capsaicin-treated rats showed more severe necrosis in the nasal cavity and greater inflammation throughout the respiratory tract than did control rats exposed to ozone. Incorporation of 5-bromo-2'-deoxyuridine (a marker of DNA synthesis associated with proliferation) into terminal bronchiolar epithelial cells was not significantly affected by capsaicin treatment in rats exposed to ozone. However, when normalized to the degree of epithelial necrosis present in each rat studied, there was less 5-bromo-2'-deoxyuridine labeling in the terminal bronchioles of capsaicin-treated rats. These observations suggest that the ozone-induced release of neuropeptides does not measurably contribute to airway inflammation but may play a role in modulating basal and reparative airway epithelial cell proliferation. (+info)

Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. (6/2566)

The substance P receptor (SPR) is a G protein-coupled receptor (GPCR) that plays a key role in pain regulation. The SPR desensitizes in the continued presence of agonist, presumably via mechanisms that implicate G protein-coupled receptor kinases (GRKs) and beta-arrestins. The temporal relationship of these proposed biochemical events has never been established for any GPCR other than rhodopsin beyond the resolution provided by biochemical assays. We investigate the real-time activation and desensitization of the human SPR in live HEK293 cells using green fluorescent protein conjugates of protein kinase C, GRK2, and beta-arrestin 2. The translocation of protein kinase C betaII-green fluorescent protein to and from the plasma membrane in response to substance P indicates that the human SPR becomes activated within seconds of agonist exposure, and the response desensitizes within 30 s. This desensitization process coincides with a redistribution of GRK2 from the cytosol to the plasma membrane, followed by a robust redistribution of beta-arrestin 2 and a profound change in cell morphology that occurs after 1 min of SPR stimulation. These data establish a role for GRKs and beta-arrestins in homologous desensitization of the SPR and provide the first visual and temporal resolution of the sequence of events underlying homologous desensitization of a GPCR in living cells. (+info)

Neurogenic plasma leakage in mouse airways. (7/2566)

1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or substance P on microvascular plasma leakage in the trachea and lungs of male pathogen-free C57BL/6 mice. 2. Single bolus intravenous injections of capsaicin (0.5 and 1 micromol kg(-1), i.v.) or substance P (1, 10 and 37 nmol kg(-10, i.v.) failed to induce significant leakage in the trachea, assessed as extravasation of Evans blue dye, but did induce leakage in the urinary bladder and skin. 3. Pretreatment with captopril (2.5 mg kg(-1), i.v.), a selective inhibitor of angiotensin converting enzyme (ACE), either alone or in combination with phosphoramidon (2.5 mg kg(-1), i.v.), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. The increase was reversed by the bradykinin B2 receptor antagonist Hoe 140 (0.1 mg kg(-1), i.v.). 4. After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung. This increase was reversed by the tachykinin (NK1) receptor antagonist SR 140333 (0.7 mg kg(-1), i.v.), but not by the NK2 receptor antagonist SR 48968 (1 mg kg(-1), i.v.). 5. Experiments using Monastral blue pigment as a tracer localized the leakage to postcapillary venules in the trachea and intrapulmonary bronchi, although the labelled vessels were less numerous in mice than in comparably treated rats. Blood vessels of the pulmonary circulation were not labelled. 6. We conclude that neurogenic inflammation can occur in airways of pathogen-free mice, but only after the inhibition of enzymes that normally degrade inflammatory peptides. Neurogenic inflammation does not involve the pulmonary microvasculature. (+info)

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (8/2566)

We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. OT-7100 did not inhibit prostaglandin E2 biosynthesis at 10(-8)-10(-4) M. Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. Single oral doses of 0.1, 0.3, 1 and 3 mg/kg OT-7100 were effective on the hyperalgesia induced by substance P in which indomethacin had no effect. Repeated oral administration of OT-7100 (10 and 30 mg/kg) was effective in normalizing the mechanical nociceptive threshold in the injured paw without affecting the nociceptive threshold in the uninjured paw in the Bennett model. Indomethacin had no effect in this model. While amitriptyline (10 and 30 mg/kg) and clonazepam (3 and 10 mg/kg) significantly normalized the nociceptive threshold in the injured paw, they also increased the nociceptive threshold in the uninjured paw. These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia. (+info)

Look up substance, substances, or substantially in Wiktionary, the free dictionary. Substance may refer to: Matter, anything ... 1988 Substance 1987, a New Order album "Substance", a song by Haste the Day on the album That They May Know You "Substance" ( ... that has mass and takes up space Chemical substance, a material with a definite chemical composition Drug substance Substance ... Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty Dravya, a term used in Jainism to refer a substance ...

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... may mean: Substance abuse, such as drug abuse Substance Abuse (band), a hip-hop group Substance Abuse, a 2009 ... the 20th episode of the anime Eureka Seven This disambiguation page lists articles associated with the title Substance Abuse. ... mixtape by Smoke DZA, re-issued in 2012 "Substance Abuse", ...

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... is a drum and bass compilation album mixed by Dieselboy. The first disc is mixed and the second disc is unmixed. ... Substance D was released on May 6, 2008, and debuted at #21 on Billboard's Electronic Album Chart. Disc One (mixed by Dieselboy ... Substance D at AllMusic www.myspace.com/humanimprint Official site v t e (Articles lacking in-text citations from October 2014 ...

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... was a British naval operation in July 1941 during the Second World War to escort convoy GM 1, the first of ...

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A biogenic substance is a product made by or of life forms. While the term originally was specific to metabolite compounds that ... An abiogenic substance or process does not result from the present or past activity of living organisms. Abiogenic products may ... The biogenic substances that tend to have lower input through the external boundaries of the strait and therefore least ... These biogenic substances are capable of withstanding the diagenesis process in sediment, but may also be transformed into ...

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A synthetic substance or synthetic compound refers to a substance that is man-made by synthesis, rather than being produced by ... It also refers to a substance or compound formed under human control by any chemical reaction, either by chemical synthesis ( ...

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Humic substances are formed by the microbial degradation of dead plant matter, such as lignin and charcoal. Humic substances in ... "humic substances". The formation of humic substances in nature is one of the least understood aspects of humus chemistry and ... or by industrial synthesis of artificial humic substances from organic feedstocks directly. These artificial substances may be ... A typical humic substance is a mixture of many molecules, some of which are based on a motif of aromatic nuclei with phenolic ...

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... may refer to: Controlled Drug Controlled substance Controlled Substances Act Drug prohibition law Regulation ... of chemicals This disambiguation page lists articles associated with the title Substance control. If an internal link led you ...

https://en.wikipedia.org/wiki/Substance_control

... adheres to classic Evangelicalism with some Neocharismatic overtones. Although Substance does not officially ... "History of Substance Church". Substance church. Retrieved May 22, 2019. "Growing Churches Blend the Old and the New" -- HERÓN ... "Substance Church , Core Values". www.substancechurch.com. Archived from the original on August 18, 2008. Substance Church Home ... Substance is known for its ultra-contemporary approaches to worship utilizing turn-tables, rap, and other forms of media. They ...

https://en.wikipedia.org/wiki/Substance_Church

Chemical substances can be simple substances (substances consisting of a single chemical element), chemical compounds, or ... For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of ... Chemical substances are often called 'pure' to set them apart from mixtures. A common example of a chemical substance is pure ... Chemical substances may be combined or converted to others by means of chemical reactions. A chemical substance may well be ...

https://en.wikipedia.org/wiki/Chemical_substance

... is an upcoming American body horror film written and directed by Coralie Fargeat, and starring Demi Moore and ... The Substance at IMDb (Articles with short description, Short description matches Wikidata, IMDb ID not in Wikidata, Upcoming ... Also that same day, Good Morning America reported that The Substance is still in production. In August 2022, Deadline Hollywood ... Hamman, Cody (February 16, 2022). "The Substance: Ray Liotta joins Demi Moore, Margaret Qualley in body horror film". JoBlo.com ...

https://en.wikipedia.org/wiki/The_Substance

And even though it was only one season, I had some of the best times of my life doing "Style & Substance." "Style & Substance ( ... Style & Substance at IMDb Style & Substance at epguides.com (Articles with short description, Short description is different ... It begs to be pointed out that "Style & Substance" lacks both. Jicha, Tom (1998-01-05). "SPOOF LACKS BOTH 'STYLE & SUBSTANCE ... The latest US sitcom, Style and Substance, has neither. Richmond, Ray (1998-01-03). "Style & Substance". Variety. Retrieved ...

https://en.wikipedia.org/wiki/Style_&_Substance

... is an amorphous gel-like substance in the extracellular space that contains all components of the ... The components of the ground substance vary depending on the tissue. Ground substance is primarily composed of water and large ... Ground substance is active in the development, movement, and proliferation of tissues, as well as their metabolism. ... Components of the ground substance are secreted by fibroblasts. Usually it is not visible on slides, because it is lost during ...

https://en.wikipedia.org/wiki/Ground_substance

... may often accompany a substance use disorder (SUD); if persistent substance-related problems exist, SUD ... Substance intoxication is a transient condition of altered consciousness and behavior associated with recent use of a substance ... multiple drug use and use of other psychoactive substances The discussion over whether the coffee (caffeine) "buzz" counted as ... doi:10.1093/bjc/azi053.{{cite journal}}: CS1 maint: multiple names: authors list (link) Look up substance intoxication in ...

https://en.wikipedia.org/wiki/Substance_intoxication

Substances are classified according to schedules and consist primarily of potentially psychoactive substances and anabolic ... Has limited exemptions to some Directory E substances, but which substances are covered and what the exemption allows depends ... A further misconception is that controlled substances laws simply list a few hundred substances (e.g. MDMA, Fentanyl, ... have statutes against health care providers self-prescribing and/or administering substances listed in the Controlled Substance ...

https://en.wikipedia.org/wiki/Controlled_substance

"Review: No Substance". Wall of Sound. Archived from the original on April 15, 2001. Retrieved October 30, 2020. No Substance at ... No Substance is the tenth full-length album by the punk rock band Bad Religion. It was the band's third (or fourth, if the ... No Substance was anticipated by both music critics and fans as a result of the band's previous worldwide successes with their ... No Substance at AllMusic "CG: bad religion". Robert Christgau. Retrieved March 3, 2012. Jacks, Kelso (June 1998). "Reviews". ...

https://en.wikipedia.org/wiki/No_Substance

This, along with Substance Abuse are considered Substance Use Disorders." In the DSM-5 (released in 2013), substance abuse and ... "Substance Use". Our World in Data. Retrieved 2 November 2018. Substance Abuse and Mental Health Services Administration, ... The dependence potential of a drug varies from substance to substance, and from individual to individual. Dose, frequency, ... Psychological stress may also result if the substance is not re-introduced. Infants also experience substance withdrawal, known ...

https://en.wikipedia.org/wiki/Substance_dependence

The properties that the substance has are said to inhere in the substance. Another primitive concept in substance theory is the ... The bundle theorist's principal objections to substance theory concern the bare particulars of a substance, which substance ... "substance" has this effect, defining "substance" as follows: [T]he idea of ours to which we give the general name substance, ... "Locke on Substance and Our Ideas of Substances". In Paul Lodge; Tom Stoneham (eds.). Locke and Leibniz on Substance. Routledge ...

https://en.wikipedia.org/wiki/Substance_theory

... may refer to: Anterior perforated substance Posterior perforated substance This disambiguation page lists ... articles associated with the title Perforated substance. If an internal link led you here, you may wish to change the link to ...

https://en.wikipedia.org/wiki/Perforated_substance

Step transaction doctrine Substance over form Gregory v. Helvering Offshore Economic Substance The Economic Substance Doctrine ... Economic substance is a doctrine in the tax law of the United States under which a transaction must have both a substantial ... The economic substance doctrine was originally a common law doctrine. The doctrine was codified in subsection (o) of section ... 1029, 1067 (March 30, 2010). Black, Stephen (2008). "A Daddy-Daughter Chat About Economic Substance". SSRN 1282195. {{cite ...

https://en.wikipedia.org/wiki/Economic_substance

... , according to the idea held by dualists and idealists, is a non-physical substance of which minds are composed ... that a substance is something which can exist without the existence of any other substance. For many philosophers, this word or ... This substance is often referred to as consciousness. This is opposed to the materialists, who hold that what we normally think ... He describes his theory of mental substance (which he calls res cogitans distinguishing it from the res extensa) in the Second ...

https://en.wikipedia.org/wiki/Mental_substance

Substance 1989 is the video version of Substance that first appeared in 1989 on VHS; it was released on LaserDisc in Japan in ... Substance (also known as Substance 1987) is a compilation album by English alternative dance band New Order. It was released in ... Type Substance in the "Search BPI Awards" field and then press Enter. "American album certifications - New Order - Substance". ... "Substance - New Order". AllMusic. Retrieved 2 November 2015. Wolk, Douglas (19 April 2005). "New Order: Substance". Blender. ...

https://en.wikipedia.org/wiki/Substance_1987

... is a potent vasodilator. Substance P-induced vasodilation is dependent on nitric oxide release. Substance P is ... Substance P has been known to stimulate cell growth in normal and cancer cell line cultures, and it was shown that substance P ... "Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles ... Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) and a member of the tachykinin ...

https://en.wikipedia.org/wiki/Substance_P

"Substance" is a song by American singer Demi Lovato. She co-wrote the track with Jutes, Laura Veltz, and its producers Alex ... "Substance" was performed on July 14, 2022, the day prior to the song's release, on Jimmy Kimmel Live. Obtained from Lovato's ... The "rock" genre has also been used as a descriptor for "Substance". On the single, Lovato sings loudly over guitars and drums ... "Demi Lovato's 'Substance' Video Is Chaotic Perfection". Paper. July 15, 2022. Retrieved July 17, 2022. "Demi Lovato muestra su ...

https://en.wikipedia.org/wiki/Substance_(song)

... or just substance storage. Ergastic substances may appear in the protoplasm, in vacuoles, or in the cell wall. Reserve ... Substances related to fats-waxes, suberin, and cutin-occur as protective layers in or on the cell wall. Animals eliminate ... Ergastic substances are non-protoplasmic materials found in cells. The living protoplasm of a cell is sometimes called the ... Cellulose and starch are the main ergastic substances of plant cells. Cellulose is the chief component of the cell wall, and ...

https://en.wikipedia.org/wiki/Ergastic_substance

A corrosive substance is one that will damage or destroy other substances with which it comes into contact by means of a ... Corrosive substances are most hazardous to eyesight. A drop of a corrosive may cause blindness within 2-10 seconds through ... The word corrosive is derived from the Latin verb corrodere, which means to gnaw, indicating how these substances seem to "gnaw ... At low concentrations, a corrosive substance is called an irritant, and its effect on living tissue is called irritation. At ...

https://en.wikipedia.org/wiki/Corrosive_substance

Another important derived quantity is the amount of substance concentration (also called amount concentration, or substance ... The amount of substance is also a convenient concept in thermodynamics. For example, the pressure of a certain quantity of a ... For example, the ratio of the mass of a sample by its amount of substance is the molar mass, whose SI unit is kilograms (or, ... In chemistry, the amount of substance n in a given sample of matter is defined as the quantity or number of discrete atomic- ...

https://en.wikipedia.org/wiki/Amount_of_substance

Substance Use Treatment Locator. Millions of Americans have a substance use disorder. Help is available, treatment works and ... Interdepartmental Substance Use Disorders Coordinating Committee (ISUDCC) *Interdepartmental Substance Use Disorders ... Interdepartmental Substance Use Disorders Coordinating Committee (ISUDCC)*Interdepartmental Substance Use Disorders ... Treatment Locators Find treatment facilities and programs in the United States or U.S. Territories for mental and substance use ...

https://www.samhsa.gov/find-treatment

Substance Abuse During Pregnancyplus icon *Prescription Opioid Pain Reliever Use During Pregnancy ... Although the aerosol of e-cigarettes generally has fewer harmful substances than cigarette smoke, e-cigarettes and other ...

https://www.cdc.gov/reproductivehealth/maternalinfanthealth/substance-abuse/e-cigarettes-pregnancy.htm

Substance Abuse see Alcohol Use Disorder (AUD); Drug Use and Addiction; Drugs and Young People ...

https://medlineplus.gov/substanceabuseproblems.html

Important information about toxic substances and how they affect our health. ... Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ... Priority List of Hazardous Substances Prioritization of substances based on a combination of their frequency, toxicity, and ... The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of ...

https://wwwn.cdc.gov/TSP/substances/substanceResources.aspx

CERCLA also requires this list to be revised periodically to reflect additional information on hazardous substances. ... of substances that are most commonly found at facilities on the National Priorities List (NPL) and which are determined to pose ... 2003 CERCLA Priority List of Hazardous Substances. The Comprehensive Environmental Response, Compensation, and Liability Act ( ... Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ...

https://www.atsdr.cdc.gov/spl/index.html

This study found that alcohol was the most commonly reported substance used among adults assessed for substance use, followed ... Among U.S. adults assessed for substance use treatment in 2019, past 30-day use of alcohol (35.8%) and multiple substances ( ... These patterns might be due to differences in substance use motivation between men and women, how substance use disorders ... These findings highlight the complex nature of substance use in the United States, the interplay between substance use and ...

https://www.medscape.com/viewarticle/975413_2

2020)‎. Substance use considerations during COVID19. World Health Organization. Regional Office for the Eastern Mediterranean. ...

https://apps.who.int/iris/handle/10665/333463

Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ... Agency for Toxic Substances and Disease Registry (ATSDR). 2001. Atlanta, GA: U.S. Department of Health and Human Services, ... Agency for Toxic Substances and Disease Registry Division of Toxicology and Human Health Sciences. 4770 Buford Highway. ... Further information about other hazardous substances my be obtained by visiting the ATSDR ToxFAQs™, which provide answers to ...

https://emergency.cdc.gov/chemical/mmg.asp

Former South Carolina Republican Party Chair Katon Dawson and MSNBCs Beth Fouhy discuss the policy changes needed in the wake of the Charleston church shooting.

https://www.msnbc.com/melissa-harris-perry/watch/beyond-the-flag--symbol-vs.-substance-472596547658

Some centers say now its harder to get substance abuse treatment covered. ...

https://www.usatoday.com/story/news/nation/2014/03/10/substance-abuse-treatment-coverage-obamacare/6176881/

Phenol is both a manufactured chemical and a natural substance. It is a colorless-to-white solid when pure. The commercial ... Agency for Toxic Substance and Disease Registration. Agency for Toxic Substance and Disease Registration. ... Priority List of Hazardous Substances - Prioritization of substances based on a combination of their frequency, toxicity, and ... Minimal Risk Levels (MRL) - The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be ...

https://wwwn.cdc.gov/TSP/substances/ToxSubstance.aspx?toxid=27

Document technique usage de substances psychoactives et dependance. Citation. World Health Organization. Regional Office for ... 2005)‎. Substance use and dependence. https://extranet.who.int/iris/restricted/handle/10665/122341 ...

https://extranet.who.int/iris/restricted/handle/10665/122341

Factsheet The bare facts We know what can and needs to be done to help reduce the burden of psychoactive substance use. ... Substance abuse refers to the harmful or hazardous use of psychoactive substances, including alcohol and illicit drugs. One of ... Other psychoactive substances. Recent estimates are that in 2008, 155 to 250 million people, or 3.5% to 5.7% of the worlds ... Other substances that were used by children and youth surveyed in Sierra Leone, included benzodiazepines such as diazepam, ...

https://www.afro.who.int/health-topics/substance-abuse

... - A blog devoted to increasing awareness of health inequities and promoting national, state, and ...

https://blogs.cdc.gov/healthequity/category/substance-abuse-prevention/

Optimise your business with the Adobe Substance 3D Collection for teams plan. ... Adobe Substance 3D brings you an ecosystem of apps and content to elevate your 3D design business. ... "The assets we created in Adobe [Substance 3D] Stager are completely on brand, rendered amazingly quickly and they look ... The Substance 3D Collection of apps and assets covers all the steps in your 3D workflow. ...

https://www.adobe.com/in/products/substance3d/collection-for-teams.html

Substance identity. Substance identity The Substance identity section is calculated from substance identification information ... substance factsheets C&L Inventory Biocidal active substance factsheets PACT tool Regulatory Obligations ... Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, ... Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, ...

https://echa.europa.eu/fr/substance-information/-/substanceinfo/100.064.602

All prohibited substances in this class are non-Specified Substances.. The following substances, and other substances with ... All prohibited substances in this class are Specified Substances except those in S6.A, which are non-Specified Substances.. ... All prohibited substances in this class are Specified Substances.. Any pharmacological substance which is not addressed by any ... All prohibited substances in this class are Specified Substances.. Substance of Abuse in this section: diamorphine (heroin). ...

https://www.wada-ama.org/en/prohibited-list

Discover the detailed plans for the Substance 3D Collection and Substance 3D Texturing offers ...

https://www.adobe.com/in/products/substance3d/compare-plans.html

... foundation for policymakers and helps community leaders and public officials worldwide to deal effectively with substance use ... Veterans with Both Substance Use and Mental Health Disorders Need Integrated Treatment. Co-occurring substance use and mental ... Treatment Motivation Among Caregivers and Adolescents with Substance Use Disorders. Treatment-seeking for substance use ... Substance Use Disorders. Featured. Addictions to, dependence on, and abuse of alcohol and drugs-from cannabis and ...

https://www.rand.org/topics/substance-use-disorders.html?page=11

Northern Area Substance Abuse Council benefits when you shop. Help today! ... Northern Area Substance Abuse Council. Sparks, Nevada. To support Northern Area Substance Abuse Council with a free iGive ... Help Northern Area Substance Abuse Council. Every purchase from great stores helps Northern Area Substance Abuse Council. ... iGive.com is the easy way to support Northern Area Substance Abuse Council. Your everyday purchases Northern Area Substance ...

https://www.igive.com/html/allcauses.cfm?causeid=12288

This is the 2nd session for the 2 part series on substance use. You will continue to learn about the most common substances ... We will also discuss the impact substance use has on families and friends. ... used by adults, concurrent disorders (substance use and mental illness), medication, treatment options, and an overview of ...

https://www.fraserhealth.ca/events/2022/Feb/feb17-substance-use-session-2

The toxic substance release data on the Tracking Network are from the Agency for Toxic Substance and Disease Registrys (ATSDR ... The acute toxic substance releases data provides information about the number of reported acute toxic substance releases in the ... track toxic substance release incidents reported by state health departments.. *monitor trends in acute toxic substance release ... Release Type - type of substance release including spills, air emissions, and other. Spills are incidents where the substance ...

http://ephtracking.cdc.gov/showToxicSubstanceLanding.action

Mental health and substance ...

http://www.emro.who.int/mental-health-section/

5, Metaphysics, 5:8), substance is that which is neither predicable of a subject nor present in a subject, e.g., the individual ... Source for information on Substance and Accident: Encyclopaedia Judaica dictionary. ... SUBSTANCE AND ACCIDENTSUBSTANCE AND ACCIDENT (Heb. עֶצֶם and מִקְרֶה respectively). According to Aristotle (Categories, ch. ... Substance , No common statement on the nature of substance is acceptable to all philosophers, the more famous of whom range ...

https://www.encyclopedia.com/religion/encyclopedias-almanacs-transcripts-and-maps/substance-and-accident

Architecture projects from Substance Architecture, an Architecture Office firm centered around Infrastructure ... Professionals that Substance Architecture has worked with. Charles Saul Engineering. Stanley Consultants. Baker Electric Inc.. ... Representatives from Substance Architecture will respond to you via e-mail. By sending this message you agree to the T&C. ... Substance Architecture has 11 projects published in our site, focused on: Infrastructure, Residential architecture, Interior ...

https://www.archdaily.com/office/substance-architecture?ad_name=project-specs&ad_medium=single

NI is committed to producing environmentally friendly products as part of the NI Hazardous Substance Reduction initiative. ... Logo 2 - Some homogenous substance within the EEP contains toxic or hazardous substances or elements above the requirements ... The restricted chemical substances regulation also defines requirements for product labeling and hazardous substance level ... Logo 1 - No part of the EEP contains toxic or hazardous substances or elements above the requirements listed in GB/T 26572-2011 ...

https://www.ni.com/en/about-ni/corporate-impact/engineering-a-healthy-planet/product-life-cycle/managing-critical-substances.html

Find the Right Substance Use Therapist in Myrtle Beach, SC - 7even Wellness Care, MS; Jonathan Bennett Jr. Renewing Minds ... Substance Use Therapists in Myrtle Beach, SC See all therapists in Myrtle Beach ...

https://www.psychologytoday.com/us/therapists/sc/myrtle-beach?category=substance-abuse&page=4

CADCI is an Addiction and Substance Abuse Counselor in Elko, NV. ... James Judd, CADCI is an Addiction and Substance Abuse Counselor ... James Judd, CADCI is an Addiction and Substance Abuse Counselor in Elko, NV. ...

https://www.healthgrades.com/providers/james-judd-xymlsgh

The Substance Use Disorders (SUDs) initiative at Massachusetts General Hospital is a hospital-wide program designed to ... transform care for the chronic disease of substance use disorder in order to improve the quality, accessibility, clinical ... Substance Use Disorders Initiative. Our initiative is designed to transform care for the chronic disease of substance use ... The Substance Use Disorders Initiative is designed to transform care for the chronic disease of substance use disorder in order ...

https://www.massgeneral.org/substance-use-disorders-initiative?TRILIBIS_EMULATOR_UA=nsclpfpr%2Cnsclpfpr

A spike in suicides and deaths by substance abuse has strained communities already struggling with a lack of clinical and ... In this webinar, Hazelden Betty Fords Stephen Delisi, MD, will examine the growing rates of substance use disorder and the ... Prioritizing Substance Abuse and Mental Health Needs with Hospital Corporation of America. ... The Department of Health and Human Services Friday released a roadmap for better integrating mental health and substance use ...

https://aha.org/topics/substance-use-disorder

This Helpline provides 24-hour free and confidential treatment referral and information about mental and/or substance use disorders, prevention, and recovery in English and Spanish. (samhsa.gov)
These patterns might be due to differences in substance use motivation between men and women, how substance use disorders manifest in each sex, barriers to treatment faced by women related to child care and fear of authority involvement, [ 6 ] and differences in the way in which sexes perceive and self-report on biopsychosocial domains. (medscape.com)
RAND research provides a firm, empirical foundation for policymakers and helps community leaders and public officials worldwide to deal effectively with substance use disorders and associated issues. (rand.org)
Co-occurring substance use and mental health disorders are common among post-9/11 veterans. (rand.org)
Receiving appropriate care is associated with lower mortality for patients with substance use disorders. (rand.org)
You will continue to learn about the most common substances used by adults, concurrent disorders (substance use and mental illness), medication, treatment options, and an overview of services offered by Fraser Health and by Community Partners. (fraserhealth.ca)
The Substance Use Disorders Initiative is designed to transform care for the chronic disease of substance use disorder in order to improve the quality, accessibility, clinical outcomes and value of treatment for our patients suffering with this illness. (massgeneral.org)
There is growing evidence that treating substance use disorders in the same way we treat patients with congestive heart failure or with diabetes-with disease management programs-can make a significant difference. (massgeneral.org)
The Mass General Substance Use Disorders (SUDs) Initiative was developed in response to Community Health Needs Assessments in Chelsea, Revere and Charlestown, in which residents identified substance use, particularly opioids, as the single greatest issue in their communities. (massgeneral.org)
This article reports on a psychological autopsy of 57 suicide victims with diagnosis of alcohol/substance abuse dependence (A/SD) & mood/anxiety disorders (M/AD) using a comprehensive typology of interpersonal stressors. (suicideinfo.ca)
Substance use disorders are on the rise and account for hundreds of billions of dollars in repercussions. (verywellmind.com)
For Board licensees with a diagnosis of substance use disorder or mental health disorders, HPSP provides a voluntary, non-disciplinary option to get treatment, establish a recovery program and be eligible to practice. (oregon.gov)
[6] Within the framework of the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-IV ), substance dependence is redefined as a drug addiction, and can be diagnosed without the occurrence of a withdrawal syndrome. (wikipedia.org)
This, along with Substance Abuse are considered Substance Use Disorders. (wikipedia.org)
[8] In the DSM-5 (released in 2013), substance abuse and substance dependence have been merged into the category of substance use disorders and they no longer exist as individual diagnoses. (wikipedia.org)
Where substance use disorders were once considered a risk factor for recidivism, they are now considered a disability that not only warrants treatment but can also diminish the share of blame one may be responsible for. (medscape.com)
This FOA also aims to promote discovery and development of novel chemical and biological approaches for prevention or mitigation of CNS complications associated with HIV infection and substance use disorders. (cdc.gov)
Alcohol use, as well as other substance use, is associate with injury, care for persons with substance use disorders. (bvsalud.org)

This study found that among adults assessed for substance use at 399 treatment centers during 2019, alcohol was the most commonly reported substance used during the past 30 days, followed by cannabis, prescription opioid misuse, and illicit stimulants. (medscape.com)
The observed high rates of polysubstance use among adults assessed for substance use treatment in 2019 are concerning and are consistent with recent drug overdose death data [ 7 ] and substance use patterns in the general population. (medscape.com)
A 2019 study suggests that substance use may predict poor relationship quality and increased conflict. (psychcentral.com)

The Toxic Substances Portal features a search engine that facilitates finding substances by substance name, CAS number (Chemical Abstract Service registry number), synonym, or trade name. (cdc.gov)
Users are also able to search for substances in other ways. (cdc.gov)
Health care professionals can search the Toxic Substances Portal for specific information about health effects caused by exposure to toxic substances. (cdc.gov)

The ATSDR ToxFAQs™ are summaries about hazardous substances developed by the ATSDR Division of Toxicology and Human Health Sciences. (cdc.gov)
The ATSDR ToxFAQs™ is a series of summaries about hazardous substances. (cdc.gov)

This social media video material (4 seconds) from the Centers for Disease Control and Prevention identifies the potential harmful substances in e-cigarette aerosol. (cdc.gov)

CEHPs include information about specific types of exposures to hazardous substances, exposure routes and pathways, health effects, and how to prevent and minimize exposures. (cdc.gov)
The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. (cdc.gov)
Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. (cdc.gov)
Answers are provided to the most frequently asked questions (FAQs) about exposure to hazardous substances found around hazardous waste sites and the effects of exposure on human health. (cdc.gov)
Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. (cdc.gov)
The listing algorithm prioritizes substances based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure to the substances found at NPL sites. (cdc.gov)
It should be noted that this priority list is not a list of "most toxic" substances, but rather a prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at NPL sites. (cdc.gov)
Thus, it is possible for substances with low toxicity but high NPL frequency of occurrence and exposure to be on this priority list. (cdc.gov)
ToxGuide pdf icon [116 KB] - Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. (cdc.gov)
Priority List of Hazardous Substances - Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. (cdc.gov)
The potential for toxic substance exposure surrounds us at home, work, and school. (cdc.gov)
Specialists in these clinics can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. (cdc.gov)
In addition to exposure data, the listing contains information documenting relationships between certain toxic substances and recognized occupational illnesses. (claimsjournal.com)
ATSDR's Toxic Substances Web Portal makes it easy for researchers and individuals to find information about toxic chemicals, understand how these chemicals can affect health, and learn how to prevent exposure. (cdc.gov)
Visit the Toxic Substances Portal to learn about the health hazards of these substances and the dangers of exposure. (cdc.gov)
ATSDR protects communities from harmful health effects related to exposure to natural and man-made hazardous substances. (cdc.gov)

A confidential and anonymous source of information for persons seeking treatment facilities in the United States or U.S. Territories for substance use/addiction and/or mental health problems. (samhsa.gov)
Combining substance abuse treatment with regular medical care can successfully treat people with opioid or alcohol addiction, providing an option that might expand treatment and lower the cost of caring for people caught up in the nation's opioid epidemic. (rand.org)
James Judd, CADCI is an Addiction and Substance Abuse Counselor in Elko, NV. (healthgrades.com)
THE CONNECTION BETWEEN CHILD ABUSE AND DRUG ADDICTION Child abuse is often a linking factor in history of substance abusers, Drug, Alcohol or other risky behaviours would fall into the category of substance abuse. (bartleby.com)
[1] [2] A drug addiction , a distinct concept from substance dependence, is defined as compulsive , out-of-control drug use, despite negative consequences. (wikipedia.org)
Someone in active addiction will typically have more difficulty empathizing with their partner or reflecting on the impact of their actions because their attachment to the substance compromises their ability to do so," explains Vanessa Kennedy , PhD, director of psychology for Driftwood Recovery. (psychcentral.com)
Substance Use Services are provided by licensed addiction counselors, licensed social workers, licensed family therapists, psychiatrists, nurse practitioners and nurses who collaborate and develop tailored treatment. (preferredbehavioral.org)
For addiction or substance abuse/misuse recovery, the best app I have found is the I am Sober app. (elizablooms.com)
Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP. (medlineplus.gov)

This article discusses the types of substances, the impact of substance abuse, and how to get help if you have a substance use disorder. (verywellmind.com)

Further information about other hazardous substances my be obtained by visiting the ATSDR ToxFAQs™ , which provide answers to the most frequently asked questions about hazardous substances. (cdc.gov)

Cambridge, MASSACHUSETTS and Osaka, JAPAN, June 23, 2020 --- Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) ("Takeda") today announced that the U.S. Food and Drug Administration (FDA) has approved the company's submission for its biologics manufacturing facility located in Brooklyn Park, Minnesota for the production of Entyvio ® (vedolizumab) drug substance. (takeda.com)

In this webinar, Hazelden Betty Ford's Stephen Delisi, MD, will examine the growing rates of substance use disorder and the impact of opioids and fentanyl on communities through his role consulting with health systems and medical professionals across the country. (aha.org)
In fact, with the exception of tobacco, it appears that AAPIs do have lower rates of substance use than the average American. (ireta.org)

SAMHSA's mission is to lead public health and service delivery efforts that promote mental health, prevent substance misuse, and provide treatments and supports to foster recovery while ensuring equitable access and better outcomes. (samhsa.gov)
Their Co-existing substance misuse and mental health issues profiles highlights a significantly higher proportion of Derby's population with risk and related factors such as socio-economic deprivation, children in poverty and violent crime. (derby.gov.uk)
Fathers who misuse substances or struggle with substance abuse tend to be less engaged with their children. (fatherhood.gov)
Substance misuse or abuse is also a risk factor for child abuse. (fatherhood.gov)

Agency for Toxic Substances and Disease Registry (ATSDR). (cdc.gov)
About 15,000 acute accidental or illegal releases of toxic substances occur in the United States every year. (cdc.gov)
The toxic substance release data on the Tracking Network are from the Agency for Toxic Substance and Disease Registry's (ATSDR) National Toxic Substance Incident Program (NTSIP). (cdc.gov)
Surveillance allows for a better understanding of the causes of incidents and injures, which can help public health officials focus prevention efforts and prepare for future toxic substance emergencies. (cdc.gov)
The acute toxic substance releases data provides information about the number of reported acute toxic substance releases in the United States. (cdc.gov)
Incidents can also occur during the transport of a toxic substance either by ground, air, pipeline, or water. (cdc.gov)
Primary Contributing Factor - main factor contributing to the release of the toxic substance, including bad weather, equipment failure, intentional or illegal acts, or operator error. (cdc.gov)
track toxic substance release incidents reported by state health departments. (cdc.gov)
monitor trends in acute toxic substance release incidents from various areas across the United States. (cdc.gov)
examine patterns and trends in locations of reported toxic substance releases, types of industries and substances involved, contributing factors, and the resulting injuries and public health actions (i.e. evacuations, decontamination). (cdc.gov)
The Toxic Substances Portal has been migrated to a new format. (cdc.gov)
The U.S. Department of Labor has added to its Web site information about occupational diseases associated with toxic substances. (claimsjournal.com)
The list is of toxic substances found at facilities covered by Energy Employees Occupational Illness Compensation Program Act (EEOICPA). (claimsjournal.com)
The department created this database to help injured workers and their families get information they need, as well as to provide an avenue for workers to offer comments or evidence on toxic substance usage and established occupational illness links. (claimsjournal.com)
What about the toxic substances we hear about in the news-mercury in canned tuna, BPA in plastic, cadmium in jewelry? (cdc.gov)
Browse through the Toxic Substances Portal today! (cdc.gov)
The Agency for Toxic Substances and Disease Registry (ATSDR) , based in Atlanta, Georgia, is a federal public health agency of the U.S. Department of Health and Human Services . (cdc.gov)

Although the aerosol of e-cigarettes generally has fewer harmful substances than cigarette smoke, e-cigarettes and other products containing nicotine are not safe to use during pregnancy. (cdc.gov)
The EU Directive on Restriction of the Use of Certain Hazardous Substances (RoHS) (2011/65/EU) restricts the use of harmful substances such as lead, mercury, and cadmium in products. (ni.com)
Suggested post copy: E-cigarette aerosol can contain harmful substances that can be inhaled deep into the lungs. (cdc.gov)

Substance abuse is over indulging or abusing a harmful substance that could be addictive. (bartleby.com)
According to the National Institute on Drug Abuse, these substances are addictive because they involve changes to the brain circuits involved in stress, reward, and self-control. (verywellmind.com)

CONTEXTE La Consommation de Substances Psychoactives chez les Adolescents est une Préoccupation Mondiale. (bvsalud.org)
OBJECTIFS Déterminer les facteurs socio-démographiques associés à la consommation de substances psychoactives chez les élèves du secondaire à Ilorin. (bvsalud.org)
RÉSULTATS La consommation de substances psychoactives était associée à des groupes d'âge plus élevés , au sexe masculin , à la consommation de substances psychoactives par les parents et à une mauvaise relation avec les parents , ainsi qu'à la localisation urbaine de l'école. (bvsalud.org)
Les facteurs qui influencent la consommation de substances psychoactives chez les adolescents servent de substrat aux interventions. (bvsalud.org)

We know what can and needs to be done to help reduce the burden of psychoactive substance use. (who.int)
Alcohol is a psychoactive substance with dependence-producing properties that has been widely used in many cultures for centuries. (who.int)
Substance dependence , also known as drug dependence , is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug. (wikipedia.org)

The objective of this priority list is to rank substances across all NPL hazardous waste sites to provide guidance in selecting which substances will be the subject of toxicological profiles prepared by ATSDR. (cdc.gov)

The International Classification of Diseases classifies substance dependence as a mental and behavioural disorder . (wikipedia.org)
[7] It was described accordingly: "When an individual persists in use of alcohol or other drugs despite problems related to use of the substance, substance dependence may be diagnosed. (wikipedia.org)
Withdrawal is the body's reaction to abstaining from a substance upon which a person has developed a dependence syndrome. (wikipedia.org)
The dependence potential of a drug varies from substance to substance, and from individual to individual. (wikipedia.org)
Substance dependence is defined by several factors, including having withdrawals, repeatedly using a substance over the course of one month and witnessing related adverse effects at home, work or school. (cnn.com)

Cannabis remains the most widely used illicit substance in the African Region. (who.int)

The study originated in the research focus 'Infections and Active Substances' at TU Braunschweig in BRICS. (idw-online.de)

[ 10 ] Continued surveillance of the illicit drug supply and substance use patterns to guide the tailored development of prevention, treatment, and harm reduction interventions will be important when devising public health strategies in U.S. communities. (medscape.com)
Actions to enhance comprehensive substance use programs that incorporate polysubstance use and co-occurring mental health problems into strategies for prevention, treatment, and response are needed, as is expanded linkage to services. (medscape.com)

Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. (cdc.gov)
Each substance on the list is a candidate to become the subject of a toxicological profile prepared by ATSDR. (cdc.gov)

Factors influencing adolescent substance use serve as a substrate for interventions. (bvsalud.org)
The association of substance use with psychiatric morbidity highlights the need to incorporate behavioural treatment in substance use interventions. (bvsalud.org)
L' association entre la consommation de substances et la morbidité psychiatrique souligne la nécessité d'intégrer un traitement comportemental dans les interventions en matière de consommation de substances. (bvsalud.org)

Licensees must provide the Diversion Coordinator with a full disclosure of the history of substance abuse, periods of treatment, efforts in recovery and relapse history, and to have a diagnosis of substance use disorder, to qualify for HPSP. (oregon.gov)
His history of mental illness is closely intertwined with a history of substance use, leading to many psychiatric hospitalizations for methamphetamine-induced psychosis. (medscape.com)

Our LGBTQ communities face a number of health disparities, including a greater risk for alcohol and substance use. (gaycenter.org)
Data supports the notion that the ED serves an important role in identifying and helping patients with alcohol and substance abuse issues. (medscape.com)

therefore, results might not be generalizable to all adults being assessed for substance use treatment. (medscape.com)
Did the Dependent Coverage Expansion Increase Risky Substance Use Among Young Adults? (rand.org)
In this essay I will discuss how I think child abuse aids is a direct cause of substance abuse in adults later in life, in addition to evidence supporting my thesis which is the fact child abuse is a linking factor to substance abuse. (bartleby.com)
Read below to learn more about Colorado's substance abuse and mental health issues: Colorado Substance Abuse Facts: In November of 2012, Colorado voted to legalize marijuana usage in small amounts for adults 21 years of age and older. (bartleby.com)

Consistent with previous research on substance use patterns in the general population, [ 1 ] men accounted for the majority of assessments for substance use treatment. (medscape.com)
[ 1 ] The finding that one third or more of assessments for substance use treatment reported more severe psychiatric problems is also consistent with previous research documenting high rates of mental illness among persons with substance use disorder. (medscape.com)
These findings highlight the complex nature of substance use in the United States, the interplay between substance use and mental illness, and the complex challenges that persons with substance use disorder face when seeking treatment. (medscape.com)
The Department of Health and Human Services today issued a notice of public rulemaking to improve the exchange of patient records used in the treatment of substance use disorder. (aha.org)
But the pace, format, and substance of these shows don't allow for a significant treatment of anything. (washingtonmonthly.com)
Recognizing a possible substance use disorder and providing a referral to treatment (perhaps using the SBIRT model ) also requires cultural competency. (ireta.org)
Behavioral health is a term used to refer to three services: mental health care, substance use treatment and recovery support. (careoregon.org)
AdCare Hospital is a substance abuse treatment provider located in Warwick, RI (Kent County). (addictiontreatmentmagazine.com)
Boston - A federal appeals court in Boston has upheld a lower court ruling that the Aroostook County Jail must provide a Madawaska woman with medication assisted treatment for her substance use disorder while she serves a 40-day sentence. (aclumaine.org)
Physicians in the emergency department (ED) regularly encounter patients seeking treatment for alcohol or substance abuse problems. (medscape.com)

Be sure to also install Substance Volume 1 Free, Substance Volume 2, Substance Volume 2 Free, Substance Volume 3, and Substance Volume 3 Free packs for more Caustic content. (google.com)

Here are the most commonly abused substances and their impacts on the individual and societal levels. (verywellmind.com)

Hazardous alcohol use was reported by 271 (42.0%) patients who screened positive with AUDIT-C. Polysubstance use, ( 2 substances) was reported by 87 participants in the past month. (bvsalud.org)

On January 16, 2016, the Chinese Ministry of Information Industry promulgated China's requirements for the 'Management Methods for Restriction of the Use of Hazardous Substances in Electronic and Electrical Products. (ni.com)
These requirements spell out Chinese policy on the Restriction of Hazardous Substances (RoHS) used in Electronic and Electrical Products (EEPs). (ni.com)

Illegal drug use is a prevalent form of substance abuse. (verywellmind.com)
Among them, alcoholism is the most common form of substance abuse. (cnn.com)

The study aimed to evaluate bacterial prevalence of dental radiology equipment and to test the effectiveness of 03 disinfection substances. (bvsalud.org)
The objectives were to determine the sociodemographic factors associated with substance use and the prevalence of associated psychiatric morbidity among secondary school students in Ilorin. (bvsalud.org)

Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. (wada-ama.org)
A spike in suicides and deaths by substance abuse has strained communities already struggling with a lack of clinical and inpatient resources. (aha.org)
This paper is an integrative literature review that analyzes the scientific production of psychoactive substances use, as well as the demographic and clinical characteristics of elderly that use psychoactive substances. (bvsalud.org)
Suspected and confirmed SARS-CoV-2 positive clinical specimens, cultures, or isolates should be packed and shipped as UN 3373 Biological Substance, Category B. (cdc.gov)

Adolescent substance use is a global concern. (bvsalud.org)
Many factors have been reported to influence adolescent substance use. (bvsalud.org)
0.01) and birth order and cocaine andhallucinogen use at P = 0.014 and P = 0.018, respectively.CONCLUSION AND RECOMMENDATION Several factors were associated with adolescent substance use in this study. (bvsalud.org)

Succinctly characterizes the toxicologic and adverse health effects information for mixtures of hazardous substances. (cdc.gov)

The House voted 220-205 today to pass legislation to hold employer-based health plans more accountable for improper denials of mental health and substance use benefits. (aha.org)
The Department of Health and Human Services Friday released a roadmap for better integrating mental health and substance use care into health care, social service and early childhood systems. (aha.org)
Services the Pemberton, Squamish and Whistler Mental Health and Substance Use teams provides to individuals in need. (eduhealth.ca)

Mots clés Santé des adolescents , médecine des adolescents , services de santé mentale en milieu scolaire, consommation d'alcool avant l'âge légal, toxicomanie , oral, pédopsychiatrie . (bvsalud.org)
Adolescents use substances for various reasons such as for pleasure , stress and anger management . (bvsalud.org)

Spills are incidents where the substance was released in a liquid or solid form. (cdc.gov)
Air emissions are incidents where the substance was released in a volatilization or aerosolized form. (cdc.gov)
Other includes incidents where the substance was released in a form other than an air emission or spill including fire, explosion and radiation. (cdc.gov)

What is the Substance Priority List (SPL)? (cdc.gov)
In CERCLA, it is called the priority list of hazardous substances that will be candidates for toxicological profiles. (cdc.gov)
This substance priority list is revised and published on a 2-year basis, with a yearly informal review and revision. (cdc.gov)
Where can I find more information on the Substance Priority List? (cdc.gov)

Assessing and managing the health and environmental risks of chemical substances under the Chemicals Management Plan. (canada.ca)
Our plan to identify, manage the health and environmental impacts of 9 groupings of chemical substances. (canada.ca)
Repairing relationships is a critical part of 12-step programs and one of the four supporting pillars of recovery, according to the Substance Abuse and Mental Health Services Administration (SAMHSA) . (psychcentral.com)
We performed an attestation review of the Substance Abuse and Mental Health Services Administration (SAMHSA) fiscal year (FY) 2012 assertions concerning drug control accounting and accompanying Table of Prior Year Drug Control Obligations: FY 2012 (Table). (hhs.gov)
Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. (msu.edu)
This framework provides clear principles to drug and alcohol services, and more broadly, health services, on working with young people with substance use concerns. (nsw.gov.au)

Organizations such as the Environmental Protection Agency (EPA) have found that the replacement options for certain hazardous substances may have an environmental impact equal to or worse than the original hazardous substance. (ni.com)
Through involvement with these organizations and close relationships with suppliers, NI stays at the forefront of both advanced technological developments in materials and compliance with worldwide regulations of hazardous substances. (ni.com)

Anatomy15

Organisms4

Diseases5

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology3

Phenomena and Processes8

Disciplines and Occupations1

Health Care2

Activity-dependent metaplasticity of inhibitory and excitatory synaptic transmission in the lamprey spinal cord locomotor network. (1/2566)

Molecular dynamics study of substance P peptides in a biphasic membrane mimic. (2/2566)

Molecular dynamics study of substance P peptides partitioned in a sodium dodecylsulfate micelle. (3/2566)

Two affinities for a single antagonist at the neuronal NK1 tachykinin receptor: evidence from quantitation of receptor endocytosis. (4/2566)

Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. (5/2566)

Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. (6/2566)

Neurogenic plasma leakage in mouse airways. (7/2566)

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (8/2566)

Substance P

Receptors, Neurokinin-1

Tachykinins

Neurokinin-1 Receptor Antagonists

Neurokinin A

Physalaemin

Receptors, Tachykinin

Eledoisin

Receptors, Neurokinin-2

Calcitonin Gene-Related Peptide

Substance-Related Disorders

Capsaicin

Receptors, Neurotransmitter

Quinuclidines

Neurokinin B

Isoindoles

Vasoactive Intestinal Peptide

Receptors, Neurokinin-3

Guinea Pigs

Neuropeptides

Substance Abuse Treatment Centers

Kassinin

Neurogenic Inflammation

Spinal Cord

Biphenyl Compounds

Neurons, Afferent

Dose-Response Relationship, Drug

Thiorphan

Piperidines

Bradykinin

Muscle, Smooth

Bombesin

Thiobarbituric Acid Reactive Substances

Rats, Sprague-Dawley

Enkephalin, Methionine

Pyrrolidonecarboxylic Acid

Muscle Contraction

Neurotensin

Humic Substances

Atropine

Ileum

Nerve Fibers

Neurotransmitter Agents

Hazardous Substances

Ganglia, Spinal

Neprilysin

Electric Stimulation

Parotid Gland

Kidney Pelvis

Diagnosis, Dual (Psychiatry)

Rats, Inbred Strains

Neurons

Acetylcholine

Trachea

Injections, Spinal

Somatostatin

Street Drugs

Ganglia, Sympathetic

Rats, Wistar

Serotonin

p-Methoxy-N-methylphenethylamine

Histamine

Radioimmunoassay

Pain

Time Factors

Neuropeptide Y

Salivation

Extravasation of Diagnostic and Therapeutic Materials

Guanethidine

Immunohistochemistry

Iris

Histamine Release

Nociceptors

Myenteric Plexus

Peptide Fragments

Marijuana Abuse

Substance Abuse Detection

Tetrodotoxin

Vasodilation

Capillary Permeability