Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Mice, Inbred DBASequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Mice, Inbred C57BLPhenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Genetic Variation: Genotypic differences observed among individuals in a population.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Mice, Inbred C3HPhylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Mice, Inbred AKRInbreeding: The mating of plants or non-human animals which are closely related genetically.Mice, Inbred AMuridae: A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Chromosomes, Mammalian: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.Mycobacterium avium subsp. paratuberculosis: A subspecies of gram-positive, aerobic bacteria. It is the etiologic agent of Johne's disease (PARATUBERCULOSIS), a chronic GASTROENTERITIS in RUMINANTS.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Mice, Inbred BALB CDNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Hybridization, Genetic: The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.Genetics, Behavioral: The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Paratuberculosis: A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Animals, Outbred Strains: Animals that are generated from breeding two genetically dissimilar strains of the same species.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Genes, Bacterial: The functional hereditary units of BACTERIA.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Mice, Congenic: Mouse strains constructed to possess identical genotypes except for a difference at a single gene locus.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Mice, Inbred CBAPolymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.Animals, Wild: Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Francisella tularensis: The etiologic agent of TULAREMIA in man and other warm-blooded animals.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Flurothyl: A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Salmonella enterica: A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.Quantitative Trait, Heritable: A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)Base Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Genes, rRNA: Genes, found in both prokaryotes and eukaryotes, which are transcribed to produce the RNA which is incorporated into RIBOSOMES. Prokaryotic rRNA genes are usually found in OPERONS dispersed throughout the GENOME, whereas eukaryotic rRNA genes are clustered, multicistronic transcriptional units.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Bacterial Proteins: Proteins found in any species of bacterium.Rats, Inbred BNChromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Tularemia: A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.RNA, Bacterial: Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.Leukemia Virus, Murine: Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
Over 400 standardized, inbred strains have been developed. Most laboratory mice are hybrids of different subspecies, most ... inbred mouse strain and initiated the systematic generation of inbred strains. The mouse has since been used extensively as a ... "BALB/c". Inbred Strains of Mice. Jackson Laboratory. Retrieved 2007-04-16. "BALB/cByJ". Jax Mice Data Sheet. Jackson Laboratory ... The average litter size is 10-12 during optimum production, but is highly strain-dependent. As a general rule, inbred mice tend ...
Familiar albino animals include in-bred strains of laboratory animals (rats, mice, guinea-pigs and rabbits), but populations of ... and two sub-species of the smooth newt (Lissotriton vulgaris vulgaris and Lissotriton vulgaris meridionalis). Albinism in ... Examples include the BALB/c mouse and Wistar and Sprague Dawley rat strains, laboratory rabbits, guinea-pigs and ferrets. ... In mice, a total of 100 genes are known to affect albinism. All the genetic traits for albinism are recessive traits. This ...
Some populations are hybrids of different subspecies, including the Japanese house mouse (M. m. molossinus). House mice usually ... Since inbreeding is detrimental, it tends to be avoided. In the house mouse, the major urinary protein (MUP) gene cluster ... Human domestication led to numerous strains of "fancy" or hobby mice with a variety of colours and a docile temperament. ... The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most ...
Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer ... The fluorescent strains are tradenamed GloFish; other cultivated varieties include "golden", "sandy", "longfin" and "leopard". ... Xanthistic forms of both the zebra and leopard pattern, along with long-finned subspecies, have been obtained via selective ... "A Point Of View: Fly, Fish, Mouse and Worm". BBC. June 14, 2013. Retrieved June 15, 2013. British Association of Zebrafish ...
As it lands, the energy of the jump is converted into strain energy made when its leg tendons are stretched. As it leaps back ... Marsupials are at a convenient degree of evolutionary divergence from humans; mice are too close and have not developed many ... However, the fragmentation of its range has led to high amounts of inbreeding and morphological abnormalities in some ... The Western Australia Department of Environment and Conservation listed these populations as subspecies; M. e. derbianus, M. e ...
In wild strains, a more fragile rachis allows the ear to easily shatter and disperse the spikelets. Selection for these traits ... F1 hybrid wheat cultivars should not be confused with the standard method of breeding inbred wheat cultivars by crossing two ... Rodents can also cause major losses during storage, and in major grain growing regions, field mice numbers can sometimes build ... Spelt is sometimes considered a subspecies[by whom?] of the closely related species common wheat (T. aestivum), in which case ...
This effect of inbreeding on infant mortality is probably largely a result of increased expression of deleterious recessive ... Trade is regulated, as all species are listed by CITES in Appendix II, except 50 species and subspecies listed in Appendix I, ... They range in typical size from Madame Berthe's mouse lemur, which weighs only 30 g (1 oz), to the eastern gorilla, weighing ... A bony ridge above the eye sockets reinforces weaker bones in the face, which are put under strain during chewing. ...
The transfer of females or males from their native group is likely an adaptation for avoiding inbreeding.[104] An analysis of ... A tiny mouse lemur holds a cut piece of fruit in its hands and eats ... except 50 species and subspecies listed in Appendix I, which gain full protection from trade.[191][192] Common threats to ... which are put under strain during chewing. Strepsirrhines have a postorbital bar, a bone around the eye socket, to protect ...
The transfer of females or males from their native group is likely an adaptation for avoiding inbreeding.[103] An analysis of ... They range in typical size from Madame Berthe's mouse lemur, which weighs only 30 g (1 oz), to the eastern gorilla, weighing ... except 50 species and subspecies listed in Appendix I, which gain full protection from trade.[191][192] Common threats to ... which are put under strain during chewing. Strepsirrhines have a postorbital bar, a bone around the eye socket, to protect ...
In wild strains, a more fragile rachis allows the ear to easily shatter and disperse the spikelets.[15] Selection for these ... The standard method of breeding inbred wheat cultivars is by crossing two lines using hand emasculation, then selfing or ... CSIRO Rodent Management Research Focus: Mice plagues Archived 21 July 2010 at the Wayback Machine ... Spelt is sometimes considered a subspecies[by whom?] of the closely related species common wheat (T. aestivum), in which case ...
We analyzed two such isolates from the AKR mice to identify their ERV progenitors and to look for evidence of recombination. ... Xmv67 originated in the Asian mice. These data indicate that the recombinant X-MLVs that can be generated during ... but not in the C57BL/6 mice. This suggests that AKR6 is the product of one, not two, recombination events. ... Naturally-occurring lymphomagenesis is induced by mouse leukemia viruses (MLVs) carried as endogenous retroviruses (ERVs). ...
... laboratory mouse strain) embryos. Thus, ART for 37 wild-derived strains was devised successfully and is now routinely used for ... A conventional embryo transfer protocol could be applied to 25 out of the 35 strains tested. In the remaining 10 strains, live ... we sought to devise ART for 37 wild-derived strains from five subspecies of Mus musculus maintained at the BRC. Superovulation ... A number of wild-derived strains are available from the RIKEN BioResource Center (BRC), but they have been maintained as living ...
We measured four sperm dimensions from cauda epididymis smears of 28 wild-caught mice of both subspecies. As inbred mouse ... and these differences were consistent for wild mice and wild-derived strains pooled over genomes. When the inbred strains were ... we further studied four wild-derived inbred strains from each subspecies. The subspecies differed significantly in terms of ... the size of sperm components differ in the two house mouse subspecies studied, and that (2) wild-derived strains reflect this ...
PWD/Ph mice exhibit differences that are genetically distinct from common laboratory mice for a number of complex phenotypic ... This strain is an excellent tool for mapping both single-gene (Mendelian) traits and quantitative trait loci (QTL) contributing ... PWD/PhJ is an inbred mouse strain of the subspecies ,i,Mus musculus musculus,/i,. ... PWD/Ph is an inbred mouse strain descended from a single pair of mice of the subspecies Mus musculus musculus caught in 1972 in ...
It is estimated that Asian mice contributed 21% of the genomes of the laboratory inbred strains (Wadeet al. 2002). Japanese ... MSM/Ms is a mouse strain derived from the Japanese wild mouse, Mus musculus molossinus. It and a Western European subspecies, ... Currently, we are generating a series of consomic strains using two mouse strains, MSM/Ms and C57BL/6J. In consomic strains, ... 1996 The laboratory mouse and its wild relatives, pp. 1577-1596 in Genetic Variations and Strains of the Laboratory Mouse, ...
Over 400 standardized, inbred strains have been developed. Most laboratory mice are hybrids of different subspecies, most ... inbred mouse strain and initiated the systematic generation of inbred strains. The mouse has since been used extensively as a ... "BALB/c". Inbred Strains of Mice. Jackson Laboratory. Retrieved 2007-04-16. "BALB/cByJ". Jax Mice Data Sheet. Jackson Laboratory ... The average litter size is 10-12 during optimum production, but is highly strain-dependent. As a general rule, inbred mice tend ...
Genetic comparison between subspecies groups and common inbred strains (CIS) have revealed that the genetic background of CIS ... Most laboratory mice belong to a species of house mouse, Mus musculus. So far, at least three subspecies groups have been ... The MSM/Ms inbred strain was established in 1986 and 21 years later it reached F100. During breeding, no significant ... We started to establish our unique strain, MSM/Ms, from MUS in Japan in 1978. In the beginning, we kept wild mice trapped in ...
4. Strains Made from Multiple Inbred Strains. 4.1 Recombinant Inbred Strains. 4.2 Collaborative Cross Strains. 4.3 Mixed Inbred ... In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, ... 4.3 Mixed Inbred Strains. Incipient inbred stocks or inbred strains that are derived from up to three parental strains (one of ... 1.1 Mice. 1.2 Rats. 2. Laboratory codes. 3. Inbred Strains and Hybrids. 3.1 Definition 3.2 Nomenclature of Inbred Strains. 3.3 ...
Standard inbred strains. Standard inbred laboratory strains of mice are derived from domesticated hybrids generated from ... crosses between M. m. domesticus and a mix of M. m. musculus, Mus musculus molossinus, and M. m. castaneus subspecies (Bonhomme ... Recombinant inbred strains. For this study, we included 32 of the BXD recombinant inbred strains. The parental strains for all ... Square symbols, BXD recombinant inbred strains; solid circles, BXH recombinant inbred strains; open circles, wild strains; ...
"Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci, Mammalian Genome" on ... Relationship between laboratory mice and the subspecies Mus musculus domesticus based on restriction endonuclease cleavage ... Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Origins of mouse inbred ... Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Sakai, Takahiro; Kikkawa ...
First, the inbred strains of mice capture a small percentage of the variation seen in nature. The inbred strains were invariant ... Harr, B., 2006a Genomic islands of differentiation between house mouse subspecies. Genome Res. 16: 730-737. ... We resequenced classical inbred strains for all 29 loci and found that inbred strains contain only a small amount of the ... Amount of wild variation captured by classical inbred strains:. The haplotypes seen in the nine classical inbred strains are ...
... consistent with descent of the most commonly used strains from a few subspecies, such as Mus musculus musculus (4). ... in comparisons between inbred strains. We report a detailed analysis of polymorphism distribution in multiple inbred mouse ... in eight inbred strains.. We do not yet know whether claims for the utility of the mosaic structure of inbred strain sequences ... Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. B. Yalcin, J. Fullerton, S. Miller ...
... which is very extensive in mice, using an efficient mixed-model... ... We have developed an association-based approach using classical inbred strains of mice in which we correct for population ... Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res 18: ... Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. ...
... we conducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and ... With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive ... Genetic dissection of a key reproductive barrier between nascent species of house mice.. White MA1, Steffy B, Wiltshire T, ... Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have ...
The Mouse Brain Library, databases on mouse brain size and structure, and online publications. ... This server is the gateway to The Portable Dictionary of the Mouse Genome (over 20,000 gene loci), ... and subspecies of mice. Figure 4.2 Probability density of retinal ganglion cell number for 57 inbred strains.. Figure 4.3 ... and subspecies of mice.. Figure 2.2. Probability density distribution of corrected brain weights for 27 inbred strains. Figure ...
In consomic strains, effects of VitD on EAE were also sex- and genotype-dependent, whereby high VitD: 1) was protective, 2) had ... High VitD was protective in EAE in female, but not male C57BL/6J (B6) mice, and had no effect in EAE-resistant PWD/PhJ (PWD) ... High VitD was protective in EAE in female, but not male C57BL/6J (B6) mice, and had no effect in EAE-resistant PWD/PhJ (PWD) ... Analysis of expression of key known VitD metabolism genes between B6 and PWD mice revealed that their expression is genetically ...
Very few IGHV sequences of C57BL/6 and BALB/c mice were shared with strains representing major subspecies, suggesting that ... genes in four inbred wild-derived mouse strains (CAST/EiJ, LEWES/EiJ, MSM/MsJ and PWD/PhJ) and a single disease model strain ( ... This suggests a similar level of diversity is likely present in the IGH loci of other classical inbred strains. This must now ... By contrast, 83/84 inferred NOD IGHV genes had previously been observed in C57BL/6 mice. Variability among the strains examined ...
Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their ... with the remaining sequences derived mostly from the Japanese subspecies Mus musculus molossinus. However, it remains unknown ... The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. ... molossinus-derived inbred strains, MSM/Ms and JF1/Ms. MSM/Ms originated from Japanese wild mice, and the ancestry of JF1/Ms was ...
... and one inbred strain, C57BR/cd (Table 1). Inbred mouse strains are largely derived from M. m. domesticus, with minor ... Mouse genomes contain a large number of endogenous MLVs, and different Mus subspecies are highly variable in the number of MLV ... XMRV was not present in any of the mouse strains tested, and among the wild-derived mouse strains analyzed, not a single mouse ... Common inbred strains of the laboratory mouse that are susceptible to infection by mouse xenotropic gammaretroviruses and the ...
It consists of ten inbred strains originated from four mouse subspecies including the Japanese subspecies, which are widely ... Commonly used laboratory mouse strains have mosaic genomes, which are derived predominantly from the west European subspecies ... 1). Most of these strains have very remote genetic status from the commonly used laboratory mouse strains such as C57BL/6J (B6 ... Genomic polymorphisms between the laboratory strains and the Japanese subspecies-derived strains are widely used in studies of ...
... and for inbred laboratory mouse strains C3H, LP/J and SJL. Sequence reads were grouped using a novel sequence clustering ... Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to ... The studied feral specimens correspond to the subspecies Mus musculus domesticus according to their distribution as well as ... The inbred mouse strains C3H, LP/J and SJL were utilized because each strain exhibits multiple copies of gag leader sequences ...
CC-RIX mice provide a controlled genetically diverse model for studies of infection and immunology that may more closely mirror ... eight founder strains of mice (five inbreed and three wild-derived stains) were chosen (see left figure). These mice cover the ... three major Mus musculus subspecies with 90% common genetic variation with the variation uniformly distributed across the ... Briefly, 20 generations of inbreeding of the CC mice created a recombinant inbred line and crossing two of them creates a F1 CC ...
"Chromosome substitution strains: gene discovery, functional analysis, and systems studies, Mammalian Genome" on DeepDyve, the ... PWD/Ph and PWK/Ph inbred mouse strains of Mus m. musculus subspecies-a valuable resource of phenotypic variations and genomic ... Construction and characterization of a genomic BAC library for the Mus m. musculus mouse subspecies (PWD/Ph inbred strain) ... Unique inbred strain MSM/Ms established from the Japanese wild mouse. Moriwaki, K; Miyashita, N; Mita, A; Gotoh, H; Tsuchiya, K ...
To confirm that MOLF/Ei mice were hyperresponsive compared with other classical inbred strains, we examined LTA-induced IL-6 ... Such strains have large genomic contributions from other subspecies and are reported to have greater than one million years of ... Among the ∼450 established inbred mouse strains, most descended from a restricted number of founder animals derived from the ... Wild-derived strains of mice are separated from common laboratory strains by significant evolutionary distance, but are still ...
... mice obtained through a systematic cross of eight inbred founder mouse strains, five of which are classic laboratory strains ( ... In contrast, Tek alleles in the CC-RIX lines are derived from only two subspecies, M. m. domesticus and M. m. musculus, and are ... Here we show that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after ... A mouse-adapted strain of Ebola virus (MA-EBOV) does not cause hemorrhagic syndrome despite causing lethal disease in ...
  • In the early part of the 20th century Clarence Cook Little, a Harvard undergraduate was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
  • The house mouse is a well-established model organism, particularly for studying the genetics of complex traits. (genetics.org)
  • Together these results suggest that wild mice will be a valuable complement to laboratory strains for studying the genetics of complex traits. (genetics.org)
  • Casci T (2012) Mouse genetics: fruits of the Collaborative Cross. (springer.com)
  • With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. (nih.gov)
  • Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F1 sterility or incompatibilities involving the X chromosome. (nih.gov)
  • The sequencing of these six CC strains updates the efforts toward inbreeding undertaken by the UNC Systems Genetics Core. (g3journal.org)
  • The inbred strains derived from wild mice (wild strains) captured in different countries, such as MSM/Ms, KJR/Ms, SWN/Ms, HMI/Ms, NJL/Ms, BFM/2Ms, BLG2/Ms and CAST/Ei are maintained in the mouse facility of the National Institute of Genetics. (imgs.org)
  • To address these questions, we examined the influence of genetics, sex and parental origin effects on intergenerational DNA methylation profiles in the mouse liver. (biomedcentral.com)
  • Mouse resources such as Collaborative Cross, outbred stocks, Hybrid Mouse Diversity Panel, and chromosome substitution strains have been instrumental to many progresses in the studies of complex traits genetics. (elsevier.com)
  • Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. (g3journal.org)
  • For decades, the deer mouse has contributed to our understanding of population genetics, disease ecology, longevity, endocrinology and behavior. (elifesciences.org)
  • We are a multidisciplinary research group focused on a systems genetics approach to understanding diseases, development, aging, and fertility in the mouse. (unc.edu)
  • In 2002, the members of the Complex-Trait Consortium proposed to develop a new mouse genetics resource called the Collaborative Cross (CC). The CC was envisioned as a reference population for mapping multigenic traits that would be free of population structure. (unc.edu)
  • Nearly all UPEC, but few other E. coli , go through the IBC pathway in multiple inbred strains of mice (C. K. Garofalo, S. M. Martin, T.M.H., W. E. Stamm, J.I.G., and S.J.H., unpublished observations). (pnas.org)
  • Three independent events of statistically significant deviation from the expected 50:50 Mendelian inheritance ratios were observed in an interspecific backcross between the Mus musculus A/J and the Mus spretus SPRET/EiJ inbred strains. (biomedcentral.com)
  • In this study we report three independent occurrences of TRD caused by post-meiotic lethality in a single interspecific backcross population between A/J ( M. musculus ) and SPRET/EiJ ( M. spretus) mouse inbred strains. (biomedcentral.com)
  • We report elucidation of a novel regulatory function for interleukin receptor-associated kinase (IRAK)-1 binding protein 1 (IRAK1BP1, also known as SIMPL) through quantitative trait locus mapping of the TLR response in wild-derived mouse strains. (rupress.org)
  • Residual ( i.e. , segregating) heterozygosity in the CC refers to regions where more than one founder haplotype at a locus can be found within a single strain. (g3journal.org)
  • This locus contained an intron-processed retroposon that was transcribed in the mice with RVD. (nature.com)
  • New mouse transcripts were identified at this locus: an alternative Pdcd2 mRNA skipping the last two coding exons and two classes of antisense RNAs. (biomedcentral.com)
  • The result has shown that the wild strains exhibit diversity of behavioral pattern and useful for studying mouse behavior using genetic methods. (imgs.org)
  • The PRM/Alf inbred mice exhibit a huge intestinal lengthening. (pasteur.fr)
  • Therefore, in this study the B-cell immune response to native and denatured HBV core protein which both can exhibit HBe-specific epitopes was examined using a panel of mouse MABs and rabbit polyclonal antibodies to native and denatured core protein and polyclonal anti-HBe/anti-HBc antibodies from sera of infected patients. (statescale.tk)
  • Inbred mouse strains exhibit varying susceptibilities to severe herpes simplex virus (HSV)-1-related neurologic disease. (statescale.tk)
  • The single most surprising and unequivocal finding was the lack of any detectable correlation between populations of LGN neurons and RGCs, a correlation of merely 0.01 across 56 strains. (jneurosci.org)
  • Selective sweeps versus introgression - population genetic dynamics of the murine leukemia virus receptor Xpr1 in wild populations of the house mouse (Mus musculus). (mpg.de)
  • Genetic studies have identified three common variants of the ABP Alpha subunit (Abpa a , Abpa b , and Abpa c ) in Mus musculus populations with distributions that correspond roughly to those of the subspecies studied (domesticus, musculus, and castaneus, respectively). (elsevier.com)
  • The final panel of CC lines will come from the three combined populations and they will be assigned a permanant strain name with prefix 'CC', a sequential strain number, and a laboratory registration code of Unc for lines originated in the United States, Tau for line that originated in Isreal, and Gen for lines originating from Australia. (unc.edu)
  • To provide a more complete characterization of this key reproductive barrier, we conducted an F2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. (nih.gov)
  • Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice. (nih.gov)
  • Social exclusion changes histone modifications H3K4me3 and H3K27ac in liver tissue of wild house mice. (mpg.de)
  • House mice almost always live in close proximity of humans. (academickids.com)
  • House mice are light brown to black, with short hair and a light belly. (academickids.com)
  • House mice, especially males, have a characteristic musky odor. (academickids.com)
  • House mice have Harderian glands near their eyes which produce a reddish-brown discharge when the mouse is stressed. (academickids.com)
  • House mice usually walk, run or stand on all fours, but when eating, fighting or orienting themselves, they stand only on the hind legs, supported by the tail. (academickids.com)
  • House mice primarily feed on plant matter, but they will also accept meat and dairy products. (academickids.com)
  • Female house mice have an estrous cycle that is 4-6 days long, with estrus itself lasting less than a day. (academickids.com)
  • House mice live about 1-2 years on average. (academickids.com)
  • As primarily nocturnal animals, house mice have little or no color vision . (academickids.com)
  • House mice also rely on pheromones . (academickids.com)
  • House mice are useful animals for solving problems in evolutionary biology and behavioral ecology for several reasons. (utah.edu)
  • First, house mice are the model organism for biomedical sciences, and therefore they are one of the world's best-studied animals. (utah.edu)
  • However, since the vast majority of studies on house mice has been conducted in the artificial conditions of the laboratory, there is still much to learn about their behavior and ecology in natural conditions. (utah.edu)
  • This primer provides basic information about what is known about the evolution, behavior, and ecology of house mice. (utah.edu)
  • House mice are rodents (order Rodentia) because they have two pairs of chisel-like, self-sharpening incisors. (utah.edu)
  • House mice belong to the family Muridae (Old World mice) and the genus Mus . (utah.edu)
  • House mice originally evolved in Europe and Asia and have recently spread throughout the world. (utah.edu)
  • The wild house mice in the U.S. are Mus domesticus (our native mice are "deer mice" or Peromyscus ). (utah.edu)
  • Since house mice have been living in human structures for over six thousand years, our enclosures provide reasonably natural environments. (utah.edu)
  • House mice tend to live in stable social groups consisting of a single dominant, territorial male and 4-12 other adults. (utah.edu)
  • Male, but not female, F1 hybrid offspring of crosses between mice of most laboratory strains and PWD/PhJ are sterile. (jax.org)
  • Most QTL are mapped in F2 or back-crosses between inbred strains, a method with great power to detect small effects but with poor resolution: The 95% confidence interval often encompasses half a chromosome ( 7 ). (pnas.org)
  • Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss. (biomedcentral.com)
  • In consomic strains, effects of VitD on EAE were also sex- and genotype dependent, whereby high VitD: (1) was protective, (2) had no effect, and (3) unexpectedly had disease-exacerbating effects. (frontiersin.org)
  • Systemic levels of 25(OH)D differed across consomic strains, with higher levels associated with EAE protection only in females. (frontiersin.org)
  • NIG provides these consomic strains to the research community. (nig.ac.jp)
  • The deer mouse (genus Peromyscus ) is the most abundant mammal in North America, and it occupies almost every type of terrestrial habitat. (elifesciences.org)
  • Peromyscus is a genus of small North American rodents known colloquially as deer mice ( Emmons, 1840 ). (elifesciences.org)
  • When the first Peromyscus specimens were shipped to European systematicists in the late 18th century, their resemblance to the local wood mouse prompted the designation Mus sylvaticus ( Hooper, 1968 ). (elifesciences.org)