The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Chromatography, High Pressure Liquid
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Metabolic Networks and Pathways
Dose-Response Relationship, Drug
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Substance Abuse Detection
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Metabolic Detoxication, Phase I
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Chromatography, Thin Layer
Metabolic Detoxication, Drug
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
24,25-Dihydroxyvitamin D 3
Metabolic Clearance Rate
Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.
Metabolic Detoxication, Phase II
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
Cytochrome P-450 CYP2D6
Mixed Function Oxygenases
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
Rats, Inbred Strains
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Solid Phase Extraction
Principal Component Analysis
Cytochrome P-450 CYP1A2
6-Ketoprostaglandin F1 alpha
Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
A selective triazine herbicide. Inhalation hazard is low and there are no apparent skin manifestations or other toxicity in humans. Acutely poisoned sheep and cattle may show muscular spasms, fasciculations, stiff gait, increased respiratory rates, adrenal degeneration, and congestion of the lungs, liver, and kidneys. (From The Merck Index, 11th ed)
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Citric Acid Cycle
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Carbon-l3 Magnetic Resonance Study. Structure of the Metabolites of Orally Administered Quinidine in Humans | RTI
1974). Carbon-l3 Magnetic Resonance Study. Structure of the Metabolites of Orally Administered Quinidine in Humans. Journal of ... Carbon-l3 Magnetic Resonance Study. Structure of the Metabolites of Orally Administered Quinidine in Humans. ... Carbon-l3 Magnetic Resonance Study. Structure of the Metabolites of Orally Administered Quinidine in Humans ... Urinary cadmium and stroke - a case-cohort study in Danish never-smokers. ...
NIOSHTIC-2 Publications Search - 20023200 - Identification and quantification of urinary benzo[a]pyrene and its metabolites...
In this study, a bioanalytical method was proposed and evaluated to identify and quantify benzo[a]pyrene and its hydroxy- ... metabolites. This method is based on coupling a microfl ... In this study, a bioanalytical method was proposed and ... The fragmentation patterns established in this study can also be used to identify and quantify PAH metabolites in other ... Asphalt-fumes; Polycyclic-aromatic-hydrocarbons; Benzopyrenes; Chromatographic-analysis; Animal-studies; Metabolites; ...
Natural attenuation along subsurface flow paths based on modeling and monitoring of a pesticide metabolite from three case...
The soil metabolite N,N-dimethylsulfamide (DMS) is formed from two fungicidal substances: tolylfluanid and dichlofluanid. ... According to the EU guidance document on relevant metabolites in groundwater, DMS is a ... attenuation along subsurface flow paths based on modeling and monitoring of a pesticide metabolite from three case studies ...
Metabolites remarkably affected by chronic kidney diseases: Study reveals - lifealth
Metabolites remarkably affected by chronic kidney diseases: Study reveals. The fact that the TCA cycle is significantly ... "Importantly, our study identified that a group of molecules called tri-carboxylic acid (TCA) cycle metabolites are ... He said this because there is another study which proved that dozens of small molecules called metabolites are altered in this ... This study was done by the University of Washington, the University of California San Diego and The University of Texas Health ...
Study on metabolites of bioactive compounds assisted by LC-SPE-NMR | NTU Scholars
Vitamin B12 News, Articles and Research
Mothers of children with autism have many significantly different metabolite levels, study finds Now, a study by researchers at ... Study shows high folate levels associated with improved cognition in older adults A new study led by researchers from The Irish ... Study suggests vitamin B12 as a SARS-CoV-2 antiviral Researchers in the UK and Spain have used a novel drug screening approach ... Study says vitamin-magnesium combo may reduce severity of COVID-19 in seniors The COVID-19 pandemic that began in late December ...
Intraindividual variability of striatal (1)H-MRS brain metabolite measurements at 3 T - Offord Centre for Child Studies :...
A study switches from genetic | EurekAlert! Science News Releases
According to the researchers, this approach can be used to study practically all of a plants metabolites at the same time. ... The study relates to FAPESPs Thematic Project "Morphoanatomical, metabolomic and molecular studies as subsidies to the ... A study switches from genetic to metabolic analysis to reconstitute evolutionary process A new method for analyzing a living ... A study switches from genetic to metabolic analysis to reconstitute evolutionary process. Fundação de Amparo à Pesquisa do ...
Wang-Sattler R[au] - Search Results - PubMed
Among authors: wang sattler r. Metabolites. 2019 Mar 5;9(3):44. doi: 10.3390/metabo9030044. Metabolites. 2019. PMID: 30841604 ... Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies. Chak CM, Lacruz ME, Adam J, Brandmaier ... Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Floegel A, ... Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics. Tiedt S, Brandmaier S, Kollmeier H, Duering M, ...
Chemical characterization and enological potential of less frequent red grape Uruguayan varieties by study secondary...
Study of secondary grape metabolites, such as polyphenol compounds (anthocyanins, flavonols, flavan-3-ols), volatile compounds ... The Vitis viníferas studied in the present work are less frequent red grape varieties cultivated in small vineyards in southern ... characterization and enological potential of less frequent red grape Uruguayan varieties by study secondary metabolites. E. ...
Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites : lessons from the...
The aim of this study was to analyze the profile of exhaled breath volatile metabolites (BVM) and gastrointestinal symptoms in ... This protocol allows to analyze the time-course of released bioactive metabolites that could be proposed as new biomarkers of ... The fermentation of dietary fibre (DF) leads to the production of bioactive metabolites, the most volatile ones being excreted ... The targeted analysis revealed that CG increased exhaled butyrate and 5 other BVM - including the microbial metabolites 2,3- ...
Distribution and fate of HCH isomers and DDT metabolites in a tropical environment-case study Cameron Highlands-Malaysia | BMC...
CRAN - Package amanida
C7 - C30 Saturated Alkanes certified reference material, 1000 μg/mL each component in hexane
To further increase metabolite coverage and achieve high accuracy of metabolite quantification, the present proof-of-principle ... This study investigated the in vitro mechanism of action of a commercial citrus EO, Brazilian orange terpenes (BOT), on an ... Metabolites, 10(9) (2020-08-29). Untargeted metabolomics is expected to lead to a better mechanistic understanding of diseases ...
Inhibition of Dopamine Release Via Presynaptic D2 Receptors: Time Course and Functional Characteristics In Vivo | Journal of...
In vitro studies reported variable durations of autoinhibition from a few seconds (Limberger et al., 1991; Agneter et al., 1994 ... and dopamine metabolites, suggesting similar rates of DA synthesis (Dickinson et al., 1999). Moreover,in vivo microdialysis ... In vivo versus in vitro studies. The time course of DA autoinhibition in vivo represents our major observation. DA released in ... The time course of autoinhibition was studied in two groups of mice having D2 receptors: four D2+/+ mice and 10 WT mice. ...
Environmental Studies | IntechOpen
2. Effect of Environmental Change on Secondary Metabolite Production in Lichen-Forming Fungi. By Christopher Deduke, Brinda ... 9. The Fire in the Mediterranean Region: A Case Study of Forest Fires in Portugal. By Ana Cristina Gonçalves and Adélia M.O. ... meaning more people see your work not only from your own field of study, but from other related fields too. ...
Plant-Based Meats Are NOT The Same As Real Meat
The study, published in the journal Scientific Reports, discovered the beef contained 22 metabolites that the plant-based ... For the study, Duke University researchers used 36 samples. 18 samples of grass-fed beef and 18 samples of plant-based meat. ... But this recent study shows theyre really nothing alike. We knew this. Obviously, plant-based meat isnt going to resemble ... Several metabolites known to be important to human health were found either exclusively or in greater quantities in beef, ...
Immune study sheds light on vitamin D effects | The University of Edinburgh
Our study reveals one way in which vitamin D metabolites can dramatically influence the immune system. ... Cell study. By studying cells from mice and people, the researchers found vitamin D caused dendritic cells to produce more of a ... Immune study sheds light on vitamin D effects. Scientists have uncovered fresh insights into how vitamin D affects the immune ... The study, published in Frontiers of Immunology, was funded by the Medical Research Council, Biotechnology and Biological ...
Ketamine and Depression: A Breakthrough? | Discover Magazine
In the 2012 paper, (2S,6S;2R,6R)-HNK was referred to as HNK4a and, in a study of 67 patients, plasma levels of HNK4a did not ... The metabolite is called (2S,6S;2R,6R)-HNK. But is this a real breakthrough or a red herring? ... My own suspicion is that the antidepressant effects of ketamine may be driven not by a metabolite but as a kind of ... However, getting regulatory approval for such a study, which would technically (as far as I know) be a first-in-man trial of ...
Registration Dossier - ECHA
This study showed that DPG is readily biodegradable and that no persistent metabolite can be expected. ... Link to relevant study record(s). Description of key information. According to a GLP OECD (301D) study, 1,3-diphenylguanidine ... However, data assessment was difficult because the studies were poorly documented. In two studies (Chou et al., 1983 ; Kondo, ... That is the reason why a full GLP OECD 301D study was commissioned in 2015. ...
Ludwig van Beethoven - New World Encyclopedia
Beethoven moved to Vienna in 1792, where he studied for a time with Joseph Haydn in lieu of Wolfgang Amadeus Mozart, who had ... The absence of drug metabolites suggests Beethoven avoided opiate painkillers. ... although recent studies have shown that some lead poison victims have suffered from hearing loss as well. The hair analyses did ...
Post-diet rebound | Gut microbes and recurring weight gain | WeizmannCompass
In a study recently published in Nature, a research team headed by the groups of Dr. Eran Elinav of the Department of ... According to the researchers, the post-obesity microbiome is characterized by a persistent deficiency in metabolites called ... In the Nature study, the scientists reported on their creation of a machine-learning algorithm based on the mouse microbiome, ... "Our studies, which were performed in mice, showed that obesity triggers a persistent change in the microbial composition of the ...
Colorectal Cancer and Women | Yale School of Medicine
The study of metabolites and their interactions is called metabolomics, Dr. Johnsons area of expertise. "Metabolites give us ... "Tumors have metabolic activity and make metabolites that can produce energy for cell growth." In the first such study ever done ... The proteins sink, the metabolites float. The researchers run the metabolites through a mass spectrometer to get a survey of ... Metabolites are molecules formed or used during the process of metabolism. They can be produced by diet, hormones, genetic or ...
Driven Sports Lean Xtreme Review: Fat Loss & More?
Another study (funded by Sabinsa, a company that has a patent on the forskohlin derived Forslean) found that forskolin did ... 4. 5-AT (5-Etioallocholen-3b,7b,17b-Triol): A steroid metabolite and a derivative of DHEA, theres some speculation that 5-AT ... Several studies have validated 7-Ketos effects on weight loss (see Journal of Exercise Physiology, Volume 2, Number 4, October ... Nonetheless, an abstract is not a peer-reviewed study, and thats what must be performed before we can be sure of 5-ATs ...
Anne Willems group - Department of Biochemistry and Microbiology
We study environmental microbiology and plant associated bacteria and other symbioses. ... Anne Willems studied biology at Ghent University and obtained a PhD in microbiology in January 1991 at the Lab. of Microbiology ... the diversity of bacterial endophytes of plants and their potential contribution to cold tolerance and secondary metabolite ... We also studied the diversity and function of bacteria associated with macro- and micro-algae, including diatoms.. A long ...
NCT00934089 | Open-Angle Glaucoma, Ocular Hypertension Clinical Trial | pfpfizeruscom
Study Phase ICMJE Phase 2 Study Design ICMJE Allocation: Randomized. Intervention Model: Crossover Assignment. Masking: Single ... Blood samples will be collected to measure the amount of active metabolite of PF-04217329 in the plasma following dosing. ... ABOUT THIS STUDY. This study will characterize the effect of PF-04217329, alone and in combination with latanoprost, on ... Study Arms ICMJE *Experimental: PF-04217329 + placebo Active study drug + latanoprost vehicle ...
In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonis
Similar studies were performed with a metabolite of vorapaxar (M20). Vorapaxar and M20 were competitive PAR1 antagonists that ... The present study provides a comprehensive in vitro pharmacological characterization of vorapaxar interaction with the PAR1 ... and competitive binding studies. The calculated Kd and Ki values for vorapaxar increased in the presence of plasma, indicating ...
Fructan may be the real enemy and not gluten. Study suggests
Another food metabolite causing digestive problems. Previous research into fructan yielded some evidence that it does cause ... Emily Lunardo studied medical sociology at York University with a strong focus on the social determinants of health and mental ... The study in question used 59 individuals who self-diagnosed themselves with gluten-intolerance. They were each given a muesli ... They hope their study will help prompt clinicians to reconsider prescribing people gluten-free diets for gluten-sensitivity. ...
Propyl 4-hydroxybenzoate - Registration Dossier - ECHA
In a dermal in vitro study on rat skin, the main metabolite detected wasp-hydroxybenzoic acid (Bando et al., 1997). Within 12 h ... Excretion of propylparaben and its metabolites was investigated in several studies in cats, dogs and rats(Phillips et al., 1978 ... In a further feeding study in rats, propylparaben and its metabolite p-hydroxybenzoic acid were detected in blood with a ... In a study in rats, the blood concentration of propylparaben reaches a maximum after 30 minutes and then constantly declines ( ...
MetabolomicsUrineConcentrationsSpecific metaboliteUrinary metabolitesBioactive metabolitesPathwayMetabolic activityClinicalSignificantlyQuantificationFlavan-3-oBiologicalResearchersProteinsAnaloguesMicrobialSmall moleculesPathwaysCompoundsQuantifyPhthalateYuanDifferencesExcretionAbstractMicrobiomeSecondary metabolismUnivariateSerumPersistentRevealsMicrobiotaProstaglandinMicePrenatalTranscriptSpeciesVitroDeclinesMetabolismCommercially-availableVitaminBiochemicalMicrobiologyAbundanceInflammatoryAcidStructuresLevelsAssociationsSteroidPlant-based meatKetamineImmune systemHumanVivoCharacterizePolarStrainsChemical substancesDataBeefGlycemicFluxInhibitionInvestigate
- the result, published in an August 2017 article on Scientific Reports , suggests that researchers might reconstitute more accurately the whole speciation process making use of a relatively unexplored bias in the study of evolutionary science: metabolomics. (eurekalert.org)
- Metabolomics refers to an area of study focusing on the chemical substances synthesized by a living organism -- a byproduct of its metabolism -- which is used to map chemical compounds inherent to a given species. (eurekalert.org)
- Integrating Two-Dimensional Gas and Liquid Chromatography-Mass Spectrometry for Untargeted Colorectal Cancer Metabolomics: A Proof-of-Principle Study. (sigmaaldrich.com)
- The study of metabolites and their interactions is called metabolomics, Dr. Johnson's area of expertise. (yale.edu)
- In the first such study ever done, she and her colleagues used metabolomics and mass spectrometry to explore the marked differences between right-sided colon cancer in males and females. (yale.edu)
- This project is supported by the Canadian Institutes of Health Research , Canada Foundation for Innovation , and by The Metabolomics Innovation Centre (TMIC) , a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. (hmdb.ca)
- The science involved is called metabolomics and will look at metabolites, cannabinoids, turpenes and 42 other aspects of each sample, he says. (laweekly.com)
- In conclusion, metabolomics revealed that abundance of 171 out of 190 profiled metabolites differed between beef and a commercially-available plant-based meat alternative, despite comparable Nutrition Facts panels. (foodpolitics.com)
- This new area of research is known as metabolomics and it measures small molecules in the blood called metabolites. (wcrf-uk.org)
- At the Metabolomics Society Meeting 2017, Bruker announced a new solution for the quantification of metabolites in urine using Nuclear Magnetic Resonance (NMR). (manufacturingchemist.com)
- Urine is an important body fluid in metabolomics due to little interference with metabolite binding proteins. (manufacturingchemist.com)
- Metabolomics may be used to address this in genome wide association studies (GWAS) as the metabolome is downstream of the genome and interacts with diet, pathophysiology and environment. (selectbiosciences.com)
- We analyzed these small molecules in the blood and urine of non-diabetic patients with chronic kidney disease and compared the results to samples obtained from a group of healthy individuals," said by Stein Hallan, M.D., first author of the study published in EBioMedicine. (lifealth.com)
- In an oral feeding study in male cats, the test substance (168 mg/kg bw) was considered to be rapidly absorbed based on an excretion of about 87% of the test substance within 24 h via urine (Phillips et al. (europa.eu)
- 1978). In a further feeding study in rats, propylparaben and its metabolite p-hydroxybenzoic acid were detected in blood with a maximum after 30 minutes and further metabolites were detected in the urine with maxima between 90 minutes and 4 h (Derache and Gourdon, 1963). (europa.eu)
- After oral administration of 168 - 1000 mg/kg bw, main metabolites detected were p-hydroxybenzoic acid immediately after application of the test substance and p-hydroxyhippuric acid, p-hydroxybenzoic acid and conjugates with glucuronic acid in urine within 4 h after application of the test substance. (europa.eu)
- Professor Claudio Luchinat at the University of Florence, a co-founder of the Magnetic Resonance Center (CERM), said: "Metabolite quantification in human urine has proven a challenging task due to complex compositional changes from test person to test person, and even from the same person at different time points. (manufacturingchemist.com)
- The new routines introduced for urine quantification also take into account substantial matrix changes going from neonates to children/adults, which all affect metabolite chemical shifts and lead to varying overlap situations due to ionic matrix changes in these two different age classes. (manufacturingchemist.com)
- This is further evidence of expanding of our analysis support providing automatic quantification of a variety of metabolites in urine directly after the measurement. (manufacturingchemist.com)
- Yuan and his team studied metabolites by regular urine testing , during the research funded by the U.S. National Cancer Institute. (onlinecancerguide.com)
- About 75% of the dose was excreted unchanged in the feces, 16% in the urine as metabolites and 1.9% was expired as 14 CO 2 . (europa.eu)
- Metabolites in the urine were identified as MOTM and metabolites of 2-ethylhexanol. (europa.eu)
- After ingestion, the body breaks down phthalates into metabolites that are quickly excreted in urine and can be analyzed. (analytica-world.com)
- UMass Amherst researchers examined levels of 11 phthalate metabolites in urine samples from 419 women who were diagnosed with invasive breast cancer after Year 3 of the WHI. (analytica-world.com)
- Two or three urine samples from each participant - from baseline, Year 1 and Year 3 - were measured, addressing two of the challenges of studying phthalate exposure, Reeves says. (analytica-world.com)
- Previous studies examined urine samples after a breast cancer diagnosis, when exposure could have come from medical equipment or medication. (analytica-world.com)
- Half of phthalate metabolites are excreted in urine within 12 to 24 hours of exposure, Reeves says. (analytica-world.com)
- Even though researchers analyzed several urine samples from each person taken a few years apart, Reeves says the study had limitations. (analytica-world.com)
- Comparison of model SS metabolite concentrations with measured values using 1000x sampling from the Gausian distribution of the measured values based on multiple replicates per measured conditions. (fairdomhub.org)
- Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. (infiniteunknown.net)
- Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b = −2.69 (95% confidence interval [CI] = −4.33, −1.05) and b = −2.69 (95% CI = −4.22, −1.16) per log unit increase. (infiniteunknown.net)
- Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI = 1.9, 11.4) and 7.6 (95% CI = 3.2, 12.1) points lower, respectively. (infiniteunknown.net)
- Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children's intellectual development at age 7 years. (infiniteunknown.net)
- So it makes sense that if elite athletes had more of a specific metabolite to break down that acid, they wouldn't have to slow down as frequently to recover, and would be able to go faster longer. (bostonmagazine.com)
- Finally, there was a strong relationship between ripening-associated transcripts and specific metabolite groups, such as TCA-cycle organic acids and sugar phosphates, underlining the importance of the respective metabolic pathways during fruit development. (ox.ac.uk)
- In parallel, urinary metabolites of propylparaben were detected within 30 minutes after administration, indicating a limited distribution and a rapid metabolism of propylparaben. (europa.eu)
- In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. (infiniteunknown.net)
- The fermentation of dietary fibre (DF) leads to the production of bioactive metabolites, the most volatile ones being excreted in the breath. (researchportal.be)
- This protocol allows to analyze the time-course of released bioactive metabolites that could be proposed as new biomarkers of DF fermentation, potentially linked to their biological properties. (researchportal.be)
- Among these bioactive metabolites, anthracycline antibiotics such as prodigiosin are known to exhibit antitumor, antioxidant, and immunosuppressive ac tivities. (alliedacademies.org)
- Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast. (umu.se)
- They look for patterns and connections by putting the metabolites into a pathway analysis that reveals their links and shared networks. (yale.edu)
- Clinical studies of FOCM/TS pathway metabolites in individuals with ASD have consistently found a lower ratio of S-adenosyl-methionine (SAM) to S-adenosylhomocysteine (SAH), which is evidence of a lower DNA methylation capacity, as well as a lower ratio of reduced GSH to its oxidized form glutathione disulfide (GSSG), indicative of higher intracellular oxidative stress. (aiche.org)
- Tumors have metabolic activity and make metabolites that can produce energy for cell growth. (yale.edu)
- We introduce the concept of metabolic activity coupling (MAC), which finds implicative relations between the momentary production and consumption of different metabolites. (fu-berlin.de)
- The metabolite changes were reflected in the flux analysis that revealed a general decrease in metabolic activity during ripening. (ox.ac.uk)
- However, there were several distinct patterns of metabolite profile, and statistical analysis demonstrated that metabolites in the same (or closely related) pathways changed in abundance in a coordinated manner, indicating a tight regulation of metabolic activity. (ox.ac.uk)
- In the 2012 paper, (2 S ,6 S ;2 R ,6 R )-HNK was referred to as HNK4a and, in a study of 67 patients, plasma levels of HNK4a did not differ between clinical responders and non-responders ( p = 0.88). (discovermagazine.com)
- The factors, or reasons, that allow a person to participate in a clinical study. (pfizer.com)
- The factors, or reasons, that prevent a person from participating in a clinical study. (pfizer.com)
- The Mayo Clinic Cancer Center is a lead academic organization in the network, participating in a phase I program integrated with a phase II program that allows network-funded sites the flexibility to expand phase I clinical studies quickly. (mayo.edu)
- Professor H. Nishino, formerly head of the chemo prevention division of the Japanese National Cancer Institute in Tokyo and currently at the University of Medicine in Kyoto, Japan examined liver cancer prevention in high risk liver cancer patients (hepatitis C virus carriers, those with cirrhosis and/or those having a family history) in a five-year clinical study. (newhope.com)
- Large sample cohorts in clinical studies demand automated solutions capable of measuring and analysing with the highest information content and quantitative reproducibility. (manufacturingchemist.com)
- There is an increased demand of technologies being able to analyse large numbers of samples due to increased cohorts in clinical studies. (manufacturingchemist.com)
- The authors discussed a variety of anthropometric, biochemical, and clinical cardiometabolic measures as well as gut microbiota and metabolites that studies have used to determine metabotypes. (nutrition.org)
- The popular party drug has shown promise in stopping suicidal thoughts in a number of small clinical studies. (bigthink.com)
- The C3 epimers of 25-hydroxyvitamin D have lower bioactivity than the primary metabolites and, unless they are chromatographically separated, can cause clinical vitamin D levels to be overestimated. (chromatographyonline.com)
- The fact that the TCA cycle is significantly impacted by chronic kidney disease supports the view of CKD as a state of mitochondrial dysfunction and that is why metabolites remarkably affect chronic kidney disease. (lifealth.com)
- Importantly, our study identified that a group of molecules called tri-carboxylic acid (TCA) cycle metabolites are significantly affected in chronic kidney disease. (lifealth.com)
- The fact that the TCA cycle is significantly impacted in chronic kidney disease supports the view of CKD as a state of mitochondrial dysfunction," said study senior co-author Kumar Sharma, M.D., FAHA, chief of nephrology and founding director of the Center for Renal Precision Medicine at UT Health San Antonio. (lifealth.com)
- In fact, no other ketamine metabolite significantly predicted response, although one (HNK4c) was associated with non-response. (discovermagazine.com)
- In addition, further studies have shown that DHEA improves memory significantly increases the performance capabilities, strengthens the immune system, decreased body fat, supports production of estrogen and testosterone, and increases libido. (vitanatural.net)
- Significantly altered metabolite pathways associated with differential metabolites were glycine, serine and threonine metabolism, arginine and proline metabolism, and taurine and hypotaurine metabolism. (mysciencework.com)
- Conclusions: Urinary amino acid metabolites were significantly altered in children with ASD. (mysciencework.com)
- Identification and quantification of urinary benzo[a]pyrene and its metabolites from asphalt fume exposed mice by microflow LC coupled to hybrid quadruple time-of-flight mass spectrometry. (cdc.gov)
- Study of secondary grape metabolites, such as polyphenol compounds (anthocyanins, flavonols, flavan-3-ols), volatile compounds present in grapes in both free and glycoside forms (monoterpenols, norisoprenoids, benzenoids), allowed us to characterize grape varieties and to suggest the best winemaking practices to maximize their enological potential. (bio-conferences.org)
- These include catechins, which are polyphenolic antioxidant plant metabolites, specifically flavonoids called flavan-3-ols. (thephantomwriters.com)
- The fragmentation patterns established in this study can also be used to identify and quantify PAH metabolites in other biological fluids. (cdc.gov)
- The study, published in Frontiers of Immunology, was funded by the Medical Research Council, Biotechnology and Biological Sciences Research Council, Natural Environment Research Council and Wellcome. (ed.ac.uk)
- Metabolites give us information about biological processing within a sample or within a tissue," she said. (yale.edu)
- They are able to produce secondary metabolites with di verse chemical structures and biological activities. (alliedacademies.org)
- University of Helsinki researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. (news-medical.net)
- Now, a study by researchers at the Rensselaer Polytechnic Institute, Arizona State University, and the Mayo Clinic found that mothers of children with autism spectrum disorder had several marked different metabolite levels two to five years after they gave birth compared to mothers of normally developing children. (news-medical.net)
- Based on a study supported by Sao Paulo Research Foundation (FAPESP) through regular research grant , the article confirms a hypothesis on the origin and migration routes of Espeletia along the northern Andes proposed by researchers at the US National Museum of Natural History, part of the Smithsonian Institution, in the 1990s, which was hitherto partially supported by molecular markers. (eurekalert.org)
- For the study, Duke University researchers used 36 samples. (brobible.com)
- By studying cells from mice and people, the researchers found vitamin D caused dendritic cells to produce more of a molecule called CD31 on their surface and that this hindered the activation of T cells. (ed.ac.uk)
- According to the researchers, the post-obesity microbiome is characterized by a persistent deficiency in metabolites called flavonoids, whose job is to promote energy expenditure and the breakdown of fat. (weizmann.ac.il)
- The researchers run the metabolites through a mass spectrometer to get a survey of everything in the sample-perhaps 20,000 variables-which can be separated into various groups. (yale.edu)
- The researchers discovered that colorectal cancer cells on the right side generate metabolites that enable more aggressive growth in women, than in men. (yale.edu)
- 7 Keto DHEA is one of more than 150 metabolites of DHEA and is as "ultimate DHEA" by some researchers. (vitanatural.net)
- Researchers from several American academic institutions are studying the relationship between dietary change and breast cancer events and all-cause mortality. (newhope.com)
- In this new study, the Hopkins researchers administered either MDMA or salt water to the monkeys twice a day for four days. (narconon.org)
- In a related study, researchers found that heavy MDMA users have memory problems that persist for at least two weeks after they have stopped using the drug. (narconon.org)
- The study began in 2015, about two weeks before the Boston Marathon, when researchers analyzed a sample size of 15 elite athletes' poop as well as 10 sedentary control participants who weren't running any marathons. (bostonmagazine.com)
- Prospective cohort studies allow researchers to calculate disease incidence in proper time sequence, establishing exposure level before outcome is known, which provides stronger evidence than other study types. (analytica-world.com)
- The proteins sink, the metabolites float. (yale.edu)
- Co-first author Jing Ke, a scientific engineering associate at JGI, added, "Looking beyond secondary metabolites, CRAGE can be used to engineer microbes for the production of proteins, RNAs, and other molecules with a huge range of applications. (lbl.gov)
- Roughly 40 percent of those scientists have studied life science in some form, with many making x-ray diffraction measurements on crystals of proteins, nucleic acids, viruses, and other substances critical to understanding life. (bnl.gov)
- The cells in an organism have the same genome, but exhibit the most varied functions and morphologies, which are related to differences in the expression pattern of proteins and metabolites of those cells. (usp.br)
- The results showed the presence of proteins related to drought stress and the presence of secondary metabolites differentially expressed in the control when compared to treatment plants. (usp.br)
- This study was conducted to determine the rate of P-glycoprotein (P-gp) mediated efflux of digoxin analogues and metabolites, and to assess the effects of macrolide antibiotics on this efflux. (edu.au)
- Eighteen brominated sponge-derived metabolites and synthetic analogues were analyzed for antilarval settlement of Balanus improvisus. (elsevier.com)
- Analogues of hemibastadin-1 (6) were synthesized and tested for structure activity studies. (elsevier.com)
- The targeted analysis revealed that CG increased exhaled butyrate and 5 other BVM - including the microbial metabolites 2,3-butanedione and 3-hydroxybutanone - with a peak observed 6 h after CG intake. (researchportal.be)
- Our studies, which were performed in mice, showed that obesity triggers a persistent change in the microbial composition of the gut. (weizmann.ac.il)
- CRAGE is a highly efficient means of transplanting BGCs originating from one organism into many different potential production hosts simultaneously in order to identify microbial strains that are naturally capable of producing the secondary metabolite under laboratory conditions. (lbl.gov)
- He said this because there is another study which proved that dozens of small molecules called metabolites are altered in this diseases. (lifealth.com)
- The differential metabolites were further analyzed by receiver operating characteristics (ROC) curve analysis and metabolic pathways analysis. (mysciencework.com)
- Our novel method for finding EMs containing several predefined reactions can be used to identify pathways that synthesize a desired target from one or more source metabolites. (fu-berlin.de)
- Two biochemical pathways of interest in the study of ASD are the folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathways ( Figure 1 ). (aiche.org)
- The metabolite data alone allowed investigations of likely routes through the metabolic network, and, as an example, we analyze the operational feasibility of different pathways of ascorbate synthesis. (ox.ac.uk)
- The Smithsonian hypothesis was confirmed by an analysis of the secondary metabolites (i.e., the chemical compounds involved in plants' adaptations to the ecosystem), which pointed to patterns of geographic distributions and chemical diversifications in the Andean paramos. (eurekalert.org)
- The study compared 190 metabolites (chemical compounds capable of being used by the body) in meat and plant-based alternatives. (foodpolitics.com)
- Glandular trichomes contribute to the high resistance of wild tomato species against insect pests not only thanks to the metabolites they produce but also because of morphological and developmental features which support the high production of these defense compounds. (frontiersin.org)
- Secondary metabolites - the compounds produced by microbes to mediate internal and external messaging, self-defense, and chemical warfare - are the basis for hundreds of invaluable agricultural, industrial, and medical products. (lbl.gov)
- Now, a team of microbiologists and genomicists led by the Department of Energy Joint Genome Institute (JGI) has invented a genetic engineering tool, called CRAGE, that could not only make studying these compounds much easier, but also fill significant gaps in our understanding of how microbes interact with their surroundings and evolve. (lbl.gov)
- Unfortunately, the fascinating world of secondary metabolism has traditionally been very hard to study, because when microbes are brought into the lab, an artificial environment that presents little hardship or competition, they typically don't bother making these compounds. (lbl.gov)
- Plant secondary metabolites are synthesized to act as anti-herbivory compounds in plant tissues. (royalholloway.ac.uk)
- The structure-activity relationships were studied but no more efficient compounds than the natural product pterulone was obtained. (lu.se)
- In this study, a bioanalytical method was proposed and evaluated to identify and quantify benzo[a]pyrene and its hydroxy-metabolites. (cdc.gov)
- 5400 individuals) cohorts and quantify aqueous metabolites and polar lipids using the Biocrates kit in the Fenland cohort (11500 individuals). (selectbiosciences.com)
- As established here, the chromatographic method was able to quickly and accurately quantify both C3 epimers of 25-hydroxyvitamin D2 and D3 and the primary metabolites in fortified serum. (chromatographyonline.com)
- For their prospective study, the first to measure phthalate exposure before a cancer diagnosis, Reeves and UMass Amherst colleagues turned to the Women Health Initiative (WHI), a long-term national health study involving more than 160,000 postmenopausal women. (analytica-world.com)
- The study also recommends future research should take a closer look at postmenopausal women not on hormone replacement therapy because "some potentially positive, yet not statistically significant" associations were noted between the level of phthalate metabolites and breast cancer risk in this subgroup. (analytica-world.com)
- The study leader, Jian-Min Yuan, who is an associate professor of public health at the University of Minnesota, said that both NNAL and cotinine are independent factors of higher risk. (onlinecancerguide.com)
- A 2019 study published in the journal Nature Microbiology, found differences between happy people and those suffering from depression. (professorshouse.com)
- Through an advanced integrative analysis, the team discovered obvious differences in exercise-induced alterations in gut microbiota and its metabolites at both the compositional and functional levels between responders and non-responders. (hku.hk)
- At 30 days of age, piglets underwent magnetic resonance imaging (MRI) procedures to analyze structural and metabolite differences. (illinois.edu)
- In Reeves' study, "the samples were collected when everyone was healthy, so that gave us samples that were free of concern that differences in exposure could be related to the diagnosis and treatment. (analytica-world.com)
- In addition, several in vivo studies focusing on metabolism and excretion after oral ingestion and on dermal absorption and metabolism. (europa.eu)
- Geomagnetic disturbances are associated with reduced nocturnal excretion of a melatonin metabolite in humans. (emf-portal.org)
- Nocturnal excretion of a urinary melatonin metabolite among electric utility workers. (emf-portal.org)
- In the Nature study, the scientists reported on their creation of a machine-learning algorithm based on the mouse microbiome, which allowed them to predict which mice would suffer from successive cycles of obesity. (weizmann.ac.il)
- Metabolic profiling revealed pronounced shifts in the abundance of metabolites of both primary and secondary metabolism during development. (ox.ac.uk)
- Multivariate statistical analysis, including principal component analysis (PCA), and orthogonal projection to latent structure discriminant analysis (OPLS-DA), as well as univariate analysis were used to assess differential metabolites between the ASD and control groups. (mysciencework.com)
- Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. (nih.gov)
- This study showed that DPG is readily biodegradable and that no persistent metabolite can be expected. (europa.eu)
- Our study reveals one way in which vitamin D metabolites can dramatically influence the immune system. (ed.ac.uk)
- Integrated analysis of metabolite and transcript levels reveals the metabolic shifts that underlie tomato fruit development and highlight regulatory aspects of metabolic network behavior. (ox.ac.uk)
- The aim of this study was to analyze the profile of exhaled breath volatile metabolites (BVM) and gastrointestinal symptoms in healthy volunteers after a single ingestion of maltodextrin (placebo) versus chitin-glucan (CG), an insoluble DF previously shown to be fermented into short-chain fatty acids (SCFA) by the human microbiota in vitro. (researchportal.be)
- One 2014 study showed that when healthy subjects consumed certain types of soluble fiber, the effect on their microbiota suppressed the production of cortisol, a stress hormone linked with anxiety and depression. (professorshouse.com)
- Furthermore, a prediction model based on microbiota and its metabolites before exercise accurately predicted personalised glycemic responses to exercise in another 30 subjects with prediabetes. (hku.hk)
- This study suggested that microbiota and its metabolites serve as an important contributor to the metabolic benefits of exercise intervention, and also identified maladaptation of gut microbiota as a "culprit" for those individuals who do not respond to exercise intervention. (hku.hk)
- This is one of the first interventional RCT studies providing clear evidence of the role of gut microbiota on metabolic health. (hku.hk)
- The purpose of this study was to compare four different protocols for generation of tolDC - the antidiabetic drug troglitazone (TGZ DC), NF-κB inhibitor BAY 11-7082 (BAY DC), prostaglandin D2 metabolite 15d-PGJ2 (PGJ DC) and a combination of dexamethasone and 1α,25-dihydroxyvitamin D3 (DexVD3 DC) regarding phenotype, cytokine production and T cell stimulatory capacity. (sigmaaldrich.com)
- The scientists demonstrated that it is possible to replenish the missing metabolites in mice, with favorable metabolic results. (weizmann.ac.il)
- Discussion: This study demonstrates that prenatal choline deficiency has profound effects by delaying neurodevelopment as evidenced by structural and metabolic MRI assessments. (illinois.edu)
- First, it was apparent that transcript abundance was less strictly coordinated by functional group than metabolite abundance, suggesting that posttranslational mechanisms dominate metabolic regulation. (ox.ac.uk)
- Another study divided forty healthy women into two groups according to the dominant species of bacteria in their guts. (professorshouse.com)
- One British study showed that after just ten days on a fast-food diet, nearly half of the bacterial species in the subject's gut had been completely wiped out. (professorshouse.com)
- The site selection for planting this genus requires studies related to characteristics of adaptability of the species to be used. (usp.br)
- The secondary metabolite pterulone, isolated from the basidomycete Pterula species 82168 shows an selective and interesting antifungal activity, inhibiting Complex I in the respiration chain. (lu.se)
- This study investigated the in vitro mechanism of action of a commercial citrus EO, Brazilian orange terpenes (BOT), on an enterotoxigenic Escherichia coli (ETEC) isolated from pig gut and on Lactobacillus rhamnosus. (sigmaaldrich.com)
- The present study provides a comprehensive in vitro pharmacological characterization of vorapaxar interaction with the PAR1 receptor on human platelets. (discoverx.com)
- In a dermal in vitro study on rat skin, the main metabolite detected was p-hydroxybenzoic acid (Bando et al. (europa.eu)
- In a study in rats, the blood concentration of propylparaben reaches a maximum after 30 minutes and then constantly declines (Derache and Gourdon, 1963). (europa.eu)
- Metabolites are molecules formed or used during the process of metabolism. (yale.edu)
- In a dermal metabolism study on human skin, an experimental flux of 4.77 µg/cm²*h was determined for an aqueous solution of propylparaben (370 mg/L) (Dal Pozzo and Pastori, 1996). (europa.eu)
- The metabolism of propylparaben was investigated in several studies after oral and dermal administration. (europa.eu)
- The study is published in Cell Metabolism (Link to the publication), a top-tier and internationally recognised academic journal. (hku.hk)
- However, more general aspects of metabolic change during fruit development have not been studied despite the importance of metabolism in the context of final composition of the ripe fruit. (ox.ac.uk)
- A study of the quality of commercially available soy supplements suggests that less than 25% of products contain within 90% of labeled isoflavone content. (medicinenet.com)
- Older adults who took a daily multivitamin and mineral supplement with zinc and high amounts of vitamin C in a 12-week study experienced sickness for shorter periods and with less severe symptoms than counterparts in a control group receiving a placebo. (news-medical.net)
- Results of studies clearly indicate, however, that the efficacy of these diets is not solely related to the biochemical structure of the individual nutrients they contain. (wjgnet.com)
- In this study, we quantified the abundance of a broad range of metabolites by gas chromatography-mass spectrometry, analyzed a number of the principal metabolic fluxes, and in parallel analyzed transcriptomic changes during tomato fruit development. (ox.ac.uk)
- Amongst identified metabolites were various nutrients (amino acids, phenols, vitamins, unsaturated fatty acids, and dipeptides) with potentially important physiological, anti-inflammatory, and/or immunomodulatory roles-many of which remained absent in the plant-based meat alternative when compared to beef and vice versa. (foodpolitics.com)
- Several metabolites known to be important to human health were found either exclusively or in greater quantities in beef, including creatine, spermine, anserine, cysteamine, glucosamine, squalene, and the omega-3 fatty acid DHA. (brobible.com)
- 2010. Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study. . (oregonstate.edu)
- Compared with several other technologies such as HPLC-UV and HPLC-fluorescence, the new method is more sensitive and selective, and it can also provide additional useful information on the structures of the metabolites. (cdc.gov)
- Our study found that the levels of different metabolites that make up a man's metabolic 'fingerprint' in the blood were linked with his risk of developing prostate cancer. (wcrf-uk.org)
- The levels of different metabolites present in someone's blood are partly determined by diet and lifestyle. (wcrf-uk.org)
- The purpose of this research study is to determine COVID-19 antibody levels in patients with chronic conditions who receive the COVID-19 vaccine. (crohnsforum.com)
- If participants will be receiving a vaccine and are interested in the study, we will collect a sample before vaccination, and collect samples at sequential time points post-vaccination to determine antibody levels. (crohnsforum.com)
- It will be interesting to see what the study and my personal antibodies levels are. (crohnsforum.com)
- No study evaluated whether these associations persist into school age. (infiniteunknown.net)
- Nevertheless, there were some correlations between specific transcripts and metabolites, and several novel associations were identified that could provide potential targets for manipulation of fruit compositional traits. (ox.ac.uk)
- A steroid metabolite and a derivative of DHEA, there's some speculation that 5-AT might have a cortisol-suppressing effect as well. (ultimatefatburner.com)
- The plant-based meat, meanwhile, contained 31 metabolites that meat did not include. (brobible.com)
- Instead, the antidepressant effects can be attributed to a metabolite of the drug, formed in the body after taking ketamine. (discovermagazine.com)
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites. (discovermagazine.com)
- Ketamine is responsible for blocking the N-methyl-D-aspartate (NMDA) receptor, which causes an immediate alleviation of depressive effects, while another metabolite in the drug helps the effects last for hours. (bigthink.com)
- It's also a potent antioxidant, and yes, it's probably even fair to say green tea can "enhance" the immune system (see studies here , here and here ). (ultimatefatburner.com)
- Her focus is metabolites and their role in human health, particularly in colorectal cancer. (yale.edu)
- S.V.V. reports a grant from the North Dakota Beef Association to study the impact of diet quality on the relationship between red meat and human health. (foodpolitics.com)
- S.V.V reports additional grant support from USDA-NIFA-SARE (LS21-357), the Turner Institute of Ecoagriculture, and the Dixon Foundation for projects that link agricultural production systems to the nutritional/metabolite composition of foods and human health. (foodpolitics.com)
- Using human and mouse genetic approaches as well as advanced molecular and metabolic techniques we want to elucidate how metabolites regulate angiogenesis in vivo (e.g. during development and pathological angiogenesis)(Oberkersch et al. (vimm.it)
- This study will characterize the effect of PF-04217329, alone and in combination with latanoprost, on circadian intraocular pressure and blood pressure in glaucoma patients. (pfizer.com)
- Hoyt and his colleagues Kerem Bingol and Nancy Washton helped characterize one of the previously unknown secondary metabolites produced when Yoshikuni's group tested CRAGE. (lbl.gov)
- Radioactivity was excreted in the feces as unchanged TOTM (85% of the fecal radioactivity), mono- and di(2- ethylhexyl) trimellitate (MOTM and DOTM, respectively), and as unidentified polar metabolites. (europa.eu)
- In this study, five strains of actinomycetes isolated from soil were revealed to produce red-like pigments. (alliedacademies.org)
- When "good-guy" bacteria digest certain components of plant foods, they produce chemical substances known as metabolites. (professorshouse.com)
- A study published in the journal Inflammopharmacology reviewed recent data related to the role of vitamins and minerals in treating COVID-19 patients. (news-medical.net)
- However, data assessment was difficult because the studies were poorly documented. (europa.eu)
- According to Abernathy, in order for the FDA to conduct drug safety analysis in a prospective (rather than the current retrospective) fashion, drug sponsors will need a pre-specified data analysis plan and will have to collect DNA samples consistently from study participants. (genomeweb.com)
- The study, published in the journal Scientific Reports, discovered the beef contained 22 metabolites that the plant-based substitutes did not have. (brobible.com)
- so I started wondering why they would even do this study…Surprise surprise, two of the authors have connections to the beef industry. (foodpolitics.com)
- In the last part of the thesis, we show that the study of isolated subnetworks may result in undesired artifacts, and as an alternative solution, we present a method that projects the flux space onto lower dimension, while preserving key features of the network. (fu-berlin.de)
- In studies showed that 7 Keto DHEA has a similarly beneficial effect on blood clotting such as aspirin (inhibition of platelet aggregation). (vitanatural.net)
- Our large-scale and multi-center study aims to identify metabolic variations between ASD and healthy children and to investigate differential metabolites and associated pathogenic mechanisms. (mysciencework.com)