A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
A type of impedance plethysmography in which bioelectrical impedance is measured between electrodes positioned around the neck and around the lower thorax. It is used principally to calculate stroke volume and cardiac volume, but it is also related to myocardial contractility, thoracic fluid content, and circulation to the extremities.
Measurement of blood flow based on induction at one point of the circulation of a known change in the intravascular heat content of flowing blood and detection of the resultant change in temperature at a point downstream.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Elements of limited time intervals, contributing to particular results or situations.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).
The hollow, muscular organ that maintains the circulation of the blood.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.
Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
Contractile activity of the MYOCARDIUM.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Examinations used to diagnose and treat heart conditions.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Posture while lying with the head lower than the rest of the body. Extended time in this position is associated with temporary physiologic disturbances.
The posture of an individual lying face up.
Method for determining the circulating blood volume by introducing a known quantity of foreign substance into the blood and determining its concentration some minutes later when thorough mixing has occurred. From these two values the blood volume can be calculated by dividing the quantity of injected material by its concentration in the blood at the time of uniform mixing. Generally expressed as cubic centimeters or liters per kilogram of body weight.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Narrow channel in the MESENCEPHALON that connects the third and fourth CEREBRAL VENTRICLES.
Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
External decompression applied to the lower body. It is used to study orthostatic intolerance and the effects of gravitation and acceleration, to produce simulated hemorrhage in physiologic research, to assess cardiovascular function, and to reduce abdominal stress during childbirth.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
Disease having a short and relatively severe course.
The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A change in cardiovascular function resulting in a reduction in BLOOD VOLUME, and reflex DIURESIS. It occurs frequently after actual or simulated WEIGHTLESSNESS.
The position or attitude of the body.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Motion pictures of the passage of contrast medium through blood vessels.
Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Confinement of an individual to bed for therapeutic or experimental reasons.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). "General paresis" and "general paralysis" may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS.
Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
The flow of BLOOD through or around an organ or region of the body.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Translocation of body fluids from one compartment to another, such as from the vascular to the interstitial compartments. Fluid shifts are associated with profound changes in vascular permeability and WATER-ELECTROLYTE IMBALANCE. The shift can also be from the lower body to the upper body as in conditions of weightlessness.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Symptoms of cerebral hypoperfusion or autonomic overaction which develop while the subject is standing, but are relieved on recumbency. Types of this include NEUROCARDIOGENIC SYNCOPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; and neurogenic ORTHOSTATIC HYPOTENSION. (From Noseworthy, JH., Neurological Therapeutics Principles and Practice, 2007, p2575-2576)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The circulation of the BLOOD through the LUNGS.
Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Freedom from activity.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The measurement of an organ in volume, mass, or heaviness.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Pathological elevation of intra-abdominal pressure (>12 mm Hg). It may develop as a result of SEPSIS; PANCREATITIS; capillary leaks, burns, or surgery. When the pressure is higher than 20 mm Hg, often with end-organ dysfunction, it is referred to as abdominal compartment syndrome.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
The time span between the beginning of physical activity by an individual and the termination because of exhaustion.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
Plethysmographic determination in which the intensity of light reflected from the skin surface and the red cells below is measured to determine the blood volume of the respective area. There are two types, transmission and reflectance.
The measure of a BLOOD VESSEL's ability to increase the volume of BLOOD it holds without a large increase in BLOOD PRESSURE. The vascular capacitance is equal to the change in volume divided by the change in pressure.
A condition caused by the failure of body to dissipate heat in an excessively hot environment or during PHYSICAL EXERTION in a hot environment. Contrast to HEAT EXHAUSTION, the body temperature in heat stroke patient is dangerously high with red, hot skin accompanied by DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.
Dynamic three-dimensional echocardiography using the added dimension of time to impart the cinematic perception of motion. (Mayo Clin Proc 1993;68:221-40)
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
An activity in which the organism plunges into water. It includes scuba and bell diving. Diving as natural behavior of animals goes here, as well as diving in decompression experiments with humans or animals.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
The valve between the left atrium and left ventricle of the heart.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Applies to movements of the forearm in turning the palm forward or upward. When referring to the foot, a combination of adduction and inversion movements of the foot.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
A twisting deformation of a solid body about an axis. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The return of a sign, symptom, or disease after a remission.
Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
Apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.
Measurement of oxygen and carbon dioxide in the blood.
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Techniques for supplying artificial respiration to a single lung.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Recording changes in electrical impedance between electrodes placed on opposite sides of a part of the body, as a measure of volume changes in the path of the current. (Stedman, 25th ed)
Agents that prevent clotting.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
The main trunk of the systemic arteries.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
The circulation of blood through the CORONARY VESSELS of the HEART.
The vessels carrying blood away from the heart.
The hemodynamic and electrophysiological action of the HEART ATRIA.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Those areas of the hospital organization not considered departments which provide specialized patient care. They include various hospital special care wards.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The inferior part of the lower extremity between the KNEE and the ANKLE.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
The chambers of the heart, to which the BLOOD returns from the circulation.
Bleeding or escape of blood from a vessel.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
The excision of the thickened, atheromatous tunica intima of a carotid artery.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Formation or presence of a blood clot (THROMBUS) in a blood vessel within the SKULL. Intracranial thrombosis can lead to thrombotic occlusions and BRAIN INFARCTION. The majority of the thrombotic occlusions are associated with ATHEROSCLEROSIS.
A condition in which HEART VENTRICLES exhibit impaired function.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Injections made into a vein for therapeutic or experimental purposes.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
The measurement of visualization by radiation of any organ after a radionuclide has been injected into its blood supply. It is used to diagnose heart, liver, lung, and other diseases and to measure the function of those organs, except renography, for which RADIOISOTOPE RENOGRAPHY is available.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.

Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy. (1/5911)

Impaired cardiac sympathetic activity can be evaluated by 123I-metaiodobenzylguanidine (MIBG) imaging. METHODS: We studied the significance of MIBG imaging for 24 patients (age 58+/-12 y) with dilated cardiomyopathy (DCM). We compared 12 patients (group A) treated with metoprolol (dose from 30-60 mg/d) with 12 patients treated with angiotensin-converting enzyme (ACE) inhibitors. Patients were studied before treatment, after 5 mo of treatment (only in group A) and after 1 y of treatment. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio (H/M) and total defect score (TDS) from anterior planar and SPECT MIBG images, which were acquired in 4 h after tracer injection. New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF) calculated by echocardiography were also assessed. RESULTS: TDS decreased in both groups (in group A, from 30+/-7 through 23+/-9 to 18+/-10; P < 0.01, in group B, from 30+/-6 to 24+/-8; P < 0.01) and H/M was increased in both groups (in group A, from 1.87+/-0.31 through 2.03+/-0.28 to 2.14+/-0.29; P < 0.01, in group B, from 1.82+/-0.28 to 1.94+/-0.26; P < 0.05). But TDS and H/M were more improved in group A than in group B (P < 0.05). LVEF was significantly increased in only group A (from 38+/-6 through 43+/-8 to 49%+/-9%; P < 0.01). NYHA improved in both groups (in group A, from mean 2.5 through 2.1 to 1.8; P < 0.01, in group B, from mean 2.6 to 2.1; P < 0.05) but was more improved in group A than in group B (P < 0.05). CONCLUSION: Cardiac function, symptom and cardiac sympathetic activity evaluated by MIBG images improved after the beta-blocker therapy more than with the treatment that used ACE inhibitors.  (+info)

Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart. (2/5911)

Norepinephrine (NE) reuptake function is impaired in heart failure and this may participate in myocyte hyperstimulation by the neurotransmitter. This alteration can be assessed by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. METHODS: To determine whether the impairment of neuronal NE reuptake was reversible after metoprolol therapy, we studied 18 patients (43+/-7 y) with idiopathic dilated cardiomyopathy who were stabilized at least for 3 mo with captopril and diuretics. Patients underwent, before and after 6 mo of therapy with metoprolol, measurements of radionuclide left ventricular ejection fraction (LVEF), maximal oxygen consumption and plasma NE concentration. The cardiac adrenergic innervation function was scintigraphically assessed with MIBG uptake and release measurements on the planar images obtained 20 min and 4 h after tracer injection. To evaluate whether metoprolol had a direct interaction with cardiac MIBG uptake and release, six normal subjects were studied before and after a 1-mo metoprolol intake. RESULTS: In controls, neither cardiac MIBG uptake and release nor circulating NE concentration changed after the 1-mo metoprolol intake. Conversely, after a 6-mo therapy with metoprolol, patients showed increased cardiac MIBG uptake (129%+/-10% versus 138%+/-17%; P = 0.009), unchanged cardiac MIBG release and decreased plasma NE concentration (0.930+/-412 versus 0.721+/-0.370 ng/mL; P = 0.02). In parallel, patients showed improved New York Heart Association class (2.44+/-0.51 versus 2.05+/-0.23; P = 0.004) and increased LVEF (20%+/-8% versus 27%+/-8%; P = 0.0005), whereas maximal oxygen uptake remained unchanged. CONCLUSION: Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation.  (+info)

Effects of tumour necrosis factor-alpha on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function. (3/5911)

1. The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min(-1)) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. 2. Under constant flow conditions TNF (20 ng ml(-1)) caused an early (< 25 min) decrease in left ventricular developed pressure (LVDP), which was maintained for 90 min (LVDP after 90 min: control vs TNF; 110 +/- 4 vs 82 +/- 10 mmHg, P < 0.01). 3. The depression in cardiac function seen with TNF under constant flow conditions, was blocked by the ceramidase inhibitor N-oleoylethanolamine (NOE), 1 microM, (LVDP after 90 min: TNF vs TNF with NOE; 82 +/- 10 vs 11 +/- 5 mmHg, P < 0.05). 4. In hearts perfused at constant pressure, TNF caused a decrease in coronary flow rate (change in flow 20 min after TNF: control vs TNF; -3.0 +/- 0.9 vs -8.7 +/- 1.2 ml min(-1), P < 0.01). This was paralleled by a negative inotropic effect (change in LVDP 20 min after TNF: control vs TNF; -17 +/- 7 vs -46 +/- 6 mmHg, P < 0.01). The decline in function was more rapid and more severe than that seen under conditions of constant flow. 5. These data indicate that cardiac function can be disrupted by TNF on two levels, firstly via a direct, ceramidase dependant negative inotropic effect, and secondly via an indirect coronary vasoconstriction.  (+info)

Stroke volume decline during prolonged exercise is influenced by the increase in heart rate. (4/5911)

This study determined whether the decline in stroke volume (SV) during prolonged exercise is related to an increase in heart rate (HR) and/or an increase in cutaneous blood flow (CBF). Seven active men cycled for 60 min at approximately 57% peak O2 uptake in a neutral environment (i.e., 27 degrees C, <40% relative humidity). They received a placebo control (CON) or a small oral dose (i.e., approximately 7 mg) of the beta1-adrenoceptor blocker atenolol (BB) at the onset of exercise. At 15 min, HR and SV were similar during CON and BB. From 15 to 55 min during CON, a 13% decline in SV was associated with an 11% increase in HR and not with an increase in CBF. CBF increased mainly from 5 to 15 min and remained stable from 20 to 60 min of exercise in both treatments. However, from 15 to 55 min during BB, when the increase in HR was prevented by atenolol, the decline in SV was also prevented, despite a normal CBF response (i.e., similar to CON). Cardiac output was similar in both treatments and stable throughout the exercise bouts. We conclude that during prolonged exercise in a neutral environment the decline in SV is related to the increase in HR and is not affected by CBF.  (+info)

Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. (5/5911)

1. Mechanical ventilation evokes a corresponding arterial pressure variability (APV) which is decreased by beta-adrenoceptor antagonism. Therefore, in this study we set out to determine whether the respiratory-related APV can be used to assess cardiac sympathetic tone. 2. Computer-generated broad-band mechanical ventilation (0-3 Hz) was applied to Sprague-Dawley rats that had been anaesthetized with ketamine and paralysed with pancuronium. APV and its relationship to lung volume variability (LVV-APV) was systematically quantified with auto- or cross-spectral frequency domain analysis. 3. APV and LVV-APV transfer magnitudes between 0.5 and 1.5 Hz showed dose-dependent suppression by propranolol from 0.01 to 1 mg kg-1, while the static value of arterial pressure remained unchanged. Stroke volume variability, assessed by the use of a pulse contour method, exhibited a similar pattern of suppression by propranolol. In contrast, heart rate variability was not lowered with propranolol. 4. The effect of propranolol on respiratory-related APV persisted even in the presence of combined alpha-adrenoceptor and muscarinic receptor blockade by phentolamine and atropine. 5. The frequency range of 0.5-1.0 Hz was optimal for LVV-APV transfer magnitude to correlate with cardiac sympathetic tone. 6. We conclude that respiratory-related APV may provide a valid assessment of cardiac sympathetic regulation which is independent of parasympathetic and vascular sympathetic influences in ketamine-anaesthetized and positive pressure-ventilated rats.  (+info)

Ryanodine and the left ventricular force-interval and relaxation-interval relations in closed-chest dogs: insights on calcium handling. (6/5911)

OBJECTIVE: Although the myocardial force-interval and relaxation-interval relations are considered to be mechanical expressions of myocardial Ca2+ handling, correlation of these phenomena with altered Ca2+ kinetics in the intact state is limited. Thus, I sought to determine the impact of selective impairment of physiologic sarcoplasmic reticulum Ca2+ release, achieved by the use of the drug ryanodine, on these relations in the intact animal. METHODS: Twelve dogs instrumented with left ventricular manometers and piezoelectric dimension crystals were studied before and after ryanodine (4 micrograms/kg intravenously). End-systolic elastance was measured at paced heart rates of 120-180 bpm to determine the force-frequency response. Mechanical restitution and relaxation restitution were determined by measuring contractile (single beat elastance) and relaxation (peak negative dP/dt) responses for beats delivered at graded extrasystolic intervals, with normalized responses expressed as a function of extrasystolic interval. RESULTS: Ryanodine accelerated mechanical restitution (time constant 60.3 +/- 3.9 versus 81.7 +/- 10.1 ms, p < 0.05) and reduced maximal contractile response (107.5 +/- 2.1 versus 122.1 +/- 5.7%, p < 0.05), slowed early relaxation restitution (time constant 65.5 +/- 13.8 versus 36.8 +/- 3.8 ms, p < 0.05) without changing late relaxation restitution kinetics, and amplified the force-frequency response (end-systolic elastance, 180 bpm, 19.4 +/- 4.3 versus 11.4 +/- 1.2 mm Hg/ml, p < 0.05). CONCLUSIONS: These findings suggest that in the intact animal, Ca2+ handling by the sarcoplasmic reticulum is a primary determinant of mechanical restitution and early relaxation restitution, but not late relaxation restitution. Conversely, ryanodine induced augmentation of the force-frequency response indicates a central role for sarcolemmal Ca2+ influx in producing frequency potentiation.  (+info)

Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock. (7/5911)

OBJECTIVE: Epinephrine (Epi) is considered to be the drug of choice for anaphylactic shock (AS). However, the benefit of this drug on improving systemic hemodynamics in AS has never been shown. We used a canine ragweed model of AS to determine if an intravenous bolus of Epi hastened the recovery of hemodynamics and modified mediator release (Med) compared with no treatment (NT). METHODS: In one protocol (n = 8), the effects on hemodynamics of two intravenous doses of Epi (0.01 and 0.025 mg/kg) were examined for 3 h postshock in respective studies approximately three weeks apart under pentobarbital anesthesia in the same animal. In five other dogs, left ventricular (LV) mechanics were additionally determined by sonomicrometric techniques to determine changes in contractility as defined by the preload recruitable stroke-work (SW) relationship. RESULTS: Compared with NT values, Epi treatments produced only transient increases in mean arterial pressure (MAP) and cardiac output (CO) post-challenge. By 20 min postshock, CO in the Epi studies were generally lower (p < 0.05) and BP was not different from NT values. With Epi treatment, SW was reduced for a given LV end-diastolic volume compared with the control study. Epi treatments also caused relatively higher plasma thromboxane B2 concentrations postshock. CONCLUSION: Our findings indicate that, when given immediately postshock, bolus-Epi did not hasten recovery and caused impairment in LV mechanics in canine AS.  (+info)

Study on propionyl-L-carnitine in chronic heart failure. (8/5911)

AIMS: In patients with chronic heart failure, fatigue is independent of haemodynamic and neuroendocrine changes and possibly may be due to impaired muscle metabolism. Propionyl-L-carnitine, a carnitine derivative, was shown in previous studies to improve muscle metabolism. The objective of this study was to evaluate the effect of propionyl-L-carnitine on exercise capacity in mild moderate chronic heart failure patients, treated with ACE inhibitors and diuretics. METHODS AND RESULTS: This was a phase III, double-blind, randomized, parallel, multicentre study. The primary objective was the evaluation of the effect of propionyl-L-carnitine vs placebo on maximum exercise duration using a bicycle exercise test. The primary analysis performed in the intention-to-treat population (271 and 266 patients in propionyl-L-carnitine and placebo), showed no statistically significant difference between treatments. A difference of 15 s in favour of propionyl-L-carnitine was observed in the completer/complier population (P=0.092). An a priori specified subgroup analysis on patients stratified by baseline maximum exercise duration showed a trend of improvement in propionyl-L-carnitine patients with shorter maximum exercise duration. A non a priori specified analysis in patients stratified by ejection fraction (< or = 30% vs 30-40%), showed a statistically significant difference in maximum exercise duration in favour of propionyl-L-carnitine in those patients with a higher ejection fraction (40 s, P<0.01). There were no safety issues. CONCLUSION: The study fails to meet the primary objective, but confirms the good safety profile of propionyl-L-carnitine. An exploratory non-prespecified analysis suggests that propionyl-L-carnitine improves exercise capacity in patients with preserved cardiac function. This hypothesis needs to be confirmed by a specific tailored study.  (+info)

The pressure gradient technique was used to evaluate effects of respiration on left ventricular stroke volume in 22 patients: 11 normal patients; eight patients with airway obstruction; and three patients with pericardial tamponade. In normals, stroke volume, systolic pressure, and pulse pressure fell an average of 7, 3 and 11% (P , 0.01), respectively, during inspiration. In patients with airway obstruction, these parameters decreased by 25, 12 and 23% (P , 0.001), respectively. After breath-holding, stroke volume also fell immediately with the onset of inspiration in both groups. These results are consistent with a reduction in left ventricular filling during inspiration as the factor primarily responsible for the fall in stroke volume. In patients with pericardial tamponade, variations in left ventricular stroke volume, systolic pressure and pulse pressure were related to: (1) an immediate fall in stroke volume with the onset of inspiration; and (2) a subsequent increase in stroke volume ...
We determined whether chronic treatment with nipradilol, a β-blocker with vasodilating action, reduces left ventricular cavity dilation (LV remodeling) following myocardial infarction and improves cardiac performance. Myocardial infarction was produced by coronary artery ligation in 16-week-old female rats and then the rats were treated for 3-4 months with nipradilol (10 mg/kg/day) or vehicle (0.5% carboxymethylcellulose). The effect of nipradilol on LV remodeling was evaluated by assessing the left ventricular end-diastolic volume index (LVEDVI)and passive pressure-volume relation curve. Since LVEDVI depends on the infarct size, LVEDVI was compared between the vehicle and nipradilol-treated rats with similar infarct size (10-40%). At 3-4 months after myocardial infarct production, the left ventricular end-diastolic volume index in the vehicle-treated rats with myocardial infarction was significantly increased, compared with that in the sham-operated rats without infarction. The ...
Our data indicate that the benefit of CABG among patients with 3-vessel CAD varies directly with the direction and magnitude of ΔLVEF measured before operation. Thus, these data can facilitate management decisions. Although no previous investigators have undertaken this analysis, our data are consistent with and extend those of 2 previous reports in which preoperative LVEF with exercise was used to identify patients likely to benefit from CABG. Jones and coworkers12 found that the concomitant presence of 3-vessel or left main disease and a positive exercise radionuclide angiogram (either ΔLVEF ≤0% or exercise-induced worsening in wall motion or increase in end-systolic volume ,20 mL with exercise) predicted CABG-associated benefit at 3 years among patients with mildly to markedly subnormal LVEF at rest. The prognostic value of the LVEF exercise response was not evaluated among those with 3-vessel disease alone, and the influence of ischemia severity on prognosis was not examined. In a later ...
OBJECTIVE--To determine whether echocardiography and radionuclide angiography give comparable results when the left ventricular ejection fraction is measured early after myocardial infarction and thus whether, irrespective of the method used, a single value for the ejection fraction could be used as a guide for starting treatment with an angiotensin converting enzyme inhibitor. DESIGN--Prospective comparison of measurement of left ventricular ejection fraction by echocardiography and radionuclide angiography. SETTING--Coronary care units of two university teaching hospitals in Glasgow. PATIENTS--99 patients studied within 36 hours of acute myocardial infarction. OUTCOME MEASURES--Left ventricular ejection fraction assessed by echocardiography and radionuclide angiography. RESULTS--70 (77%) of the 99 patients had ejection fraction measured by both echocardiographic and radionuclide techniques, 30 in centre 1 and 40 in centre 2. In centre 1 the mean difference (SD) in ejection fraction ...
TY - JOUR. T1 - Optimal stroke volume in left-ventricular ejection. AU - Hämäläinen, Jari. PY - 1989. Y1 - 1989. N2 - Optimal value of stroke volume ejected against a given arterial load is studied, i.e. left-ventricular function is described by an optimization model. In the model, end-diastolic volume (V/sub ed/), the linear end-systolic pressure-volume relation, heart rate, and ejection time are given, and arterial load is described by the three-element windkessel model. The cost function of the model takes into account two optimality criteria for ventricular function: energy economy and efficient response to an increase in V/sub ed/. The observed stroke volumes of isolated canine hearts could be predicted quite accurately by the model. It is concluded that the left-ventricular response to a change in arterial load and V/sub ed/ can be explained by an optimization model when contractility and heart rate are kept constant. The results also strongly suggest that energy economy and efficiency ...
Results A total of 63 patients (49 females) aged from 10 to 60 years were recruited into this study. There was no significant differences in the age (P , 0.05) and the size of PDA (P , 0.05) between groups. The left atrium diameter indexes (35.96 ± 6.60 vs 31.17 ± 6.85 vs 22.24 ± 3.47 mm/m²; P , 0.05) and the left ventricular end diastolic volume indexes (279.45 ± 89.42 vs 162.88 ± 54.13 vs 60.94 ± 9.87 ml/m²; P , 0.05) decreased significantly from group A to group C. The left ventricular diameter/right ventricular diameter ratio in group C (1.86 ± 0.38) was less than that in group A (4.29 ± 1.85; P , 0.05) and group B (3.18 ± 1.21; P , 0.05) but had no significant difference between group A and group B. Linear regression analysis showed a significant correlation between the decrease in pulmonary artery mean pressure and the baseline of left ventricular end diastolic volume index (P , 0.05).. ...
TY - JOUR. T1 - Impact of Lifelong Exercise Training Dose on Ventricular-Arterial Coupling. AU - Hieda, Michinari. AU - Howden, Erin. AU - Shibata, Shigeki. AU - Fujimoto, Naoki. AU - Bhella, Paul S.. AU - Hastings, Jeffrey L. AU - Tarumi Ph.D., Takashi. AU - Sarma, Satyam. AU - Fu, Qi. AU - Zhang, Rong. AU - Levine, Benjamin D. PY - 2018/12/4. Y1 - 2018/12/4. N2 - BACKGROUND: The dynamic Starling mechanism, as assessed by beat-by-beat changes in stroke volume and left ventricular end-diastolic pressure, reflects ventricular-arterial coupling. It deteriorates with age, and is preserved in highly trained masters athletes. Currently, it remains unclear how much exercise over a lifetime is necessary to preserve efficient ventricular-arterial coupling. The purpose of this study was to assess the dose-dependent relationship between lifelong exercise training and the dynamic Starling mechanism in healthy seniors. METHODS: One hundred two seniors were recruited and stratified into 4 groups based on 25 ...
Conventional right ventricular apical pacing may result in asynchronous ventricular contraction with delayed left ventricular activation, interventricular motion abnormalities, and worsening of left ventricular ejection fraction. His pacing is preserving a synchronous contraction and may prevent a decrease in left ventricular ejection fraction.. The aims of our crossover, double-blinded, randomized study is to evaluate the feasibility and long-term safety of permanent His pacing and to compare the effects on left ventricular ejection fraction of permanent His pacing with those of conventional right septal stimulation after 12 months treatment in patients with 2nd or 3rd degree AV-block. ...
TY - JOUR. T1 - Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q92, responsible for hypertrophic cardiomyopathy. AU - Lim, Do Sun. AU - Oberst, Leslie. AU - McCluggage, Meghan. AU - Youker, Keith. AU - Lacy, Jeffrey. AU - DeMayo, Francesco. AU - Entman, Mark L.. AU - Roberts, Robert. AU - Michael, Lloyd H.. AU - Marian, Ali J.. PY - 2000. Y1 - 2000. N2 - The causality of mutant sarcomeric proteins in hypertrophic cardiomyopathy (HCM) is well established. The current emphasis is to elucidate the pathogenesis of HCM in transgenic animal models. We determined the left ventricular ejection fraction (LVEF) in transgenic mice expressing mutant cardiac troponin T (cTnT)-Q92, known to cause HCM in humans. Transgenes were constructed by placing wild-type (R92) or mutant (Q92) full-length human cTnT cDNAs 3 into a 5.5-kb murine [α-myosin heavy chain (MyHC)] promoter injected into fertilized zygotes. Three wild-type and six mutant lines were produced. ...
Background: We sought to evaluate the additional value of a multiparametric cardiac magnetic resonance (CMR) score in comparison with traditional TIMI (Thromolysis in Myocardial Infarction) score and transthoracic echocardiography (TTE) score in prognostic stratification of STEMI patients.. Methods: 209 STEMI patients reperfused by primary PCI underwent TTE and CMR 3 days after the index event. We measured: TIMI score, left ventricle ejection fraction (EFTTE), left ventricle end systolic volume (LVESVTTE) and number of myocardial segment with wall motion abnormalities (WMITTE) measured by TTE, left ventricle ejection fraction (EFCMR), left ventricle end systolic volume (LVESVCMR) and number of myocardial segment with wall motion abnormalities (WMICMR) measured by CMR, myocardial salvage index (MSI) and presence of microvascular obstruction (MVO). The primary clinical endpoint of study was the occurrence of major adverse cardiac events(MACE) defined as combined endpoint of hospitalization, acute ...
The NYHA Functional Classification classifies patients' heart failure according to the severity of their symptoms. The classification is as follows: Class I: no limitation of physical activity, ordinary physical activity does not cause undue fatigue, palpitation, or dyspnea (shortness of breath); Class II: slight limitation to physical activity, comfortable at rest, ordinary physical activity results in fatigue, palpitation or dyspnea; Class III: marked limitation of physical activity, comfortable at rest, less than ordinary activity causes fatigue, palpitation or dyspnea; Class IV: unable to carry on any physical activity without discomfort, symptoms of heart failure at rest, if any physical activity is undertaken, discomfort increases ...
If our observation of incomplete relaxation is of clinical relevance, it would be manifest as a tachycardia-induced reduction in LV end-diastolic volumes. This was indeed observed by Westermann et al. (17), who measured pressure-volume loops in 70 patients after hospital admission for heart failure with a normal ejection fraction. Compared with 20 control subjects, these patients had an increased LV wall thickness, and when paced at 120 beats/min, the LV end-diastolic volume decreased by 28%. In contrast, in control subjects, they found an incremental increase in LV end-diastolic volume. Although the authors could not explain this finding, they argued that this observation may play a substantial role in the development of symptoms in these patients.. The mechanisms underlying diastolic dysfunction in patients with LV hypertrophy are unclear. There are several possible explanations, including an increased mass-to-volume ratio, increased passive stiffness due to changes in collagen and titin, ...
Medicine Journal in MJB authors are : Ali Jasim Mhaimeed Al-Sultani,Ali Jaber Al-Mamoori,Basim Mohammed Madloom Study of Minor Echocardiographic Indices of Cardiac Systolic Function in Subjects with Normal Ejection Fraction and Correlation with Age university of babylon journals in the repository for farther content please log to http://repository.uobabylon.edu.iq
Introducción y objetivos. No está clara la asociación entre los inhibidores de la enzima de conversión de la angiotensina (IECA) o los antagonistas del receptor de la angiotensina II (ARA-II) y la mortalidad de los pacientes con síndrome coronario agudo (SCA) sometidos a intervención coronaria percutánea (ICP) con fracción de eyección del ventrículo izquierdo (FEVI) conservada. Nuestro objetivo es determinar dicha asociación en pacientes con FEVI conservada o reducida.. Métodos. Se analizaron datos procedentes del registro BleeMACS. El objetivo principal fue la mortalidad a 1 año. Se aplicaron ponderación por la probabilidad inversa del tiempo de supervivencia y ajustes por regresión de Cox, puntuación de propensión y variables instrumentales.. Resultados. De los 15.401 pacientes con SCA sometidos a ICP, se prescribieron IECA/ARA-II al 75,2%. Se produjeron 569 muertes (3,7%) durante el primer año tras el alta hospitalaria. Después del ajuste multivariado, los IECA/ARA-II se ...
R.I. Jones, A. Lahiri, P. M. M. Cashman, C. Dore, J. C. W. Crawley, E. B. Raftery; Continuous Measurement of Left Ventricular Ejection Fraction during Isometric Handgrip (Ihg) and Cold Stress (Cs) in Normal Subjects. An Assessment of the Response and Reproducibility. Clin Sci (Lond) 1 February 1984; 66 (2): 27P. doi: https://doi.org/10.1042/cs066027Pa_pt2. Download citation file:. ...
Left ventricular volumes Several studies compared 2D echocardiography and CMR for assessment of left ventricular volumes and LVEF.[5, 11-14] These studies differ in number of included patients, aetiology of heart disease and left ventricular function and volume, but all consistently show underestimation of EDV and ESV by 2D echocardiography compared with CMR. Reported mean differences vary considerably between studies and range from 10 to 94 ml for ESV and from 11 to 131 for EDV.[5, 19] We found the discrepancy between the two imaging modalities to be strongly related to left ventricular volume, with increasing differences in larger hearts. This finding is supported by a smaller study by Gruszczynska et al. in ischaemic heart failure patients.[13] It is further corroborated by the observation that studies in hearts with predominantly (near) normal volumes report lower differences, whereas studies including dilated hearts are at the higher end of the spectrum.[5, 11, 14, 20]. The underestimation ...
f(1)= 20, f(3)=13, f(5)=15, f(7)=16, f(9)=11, on [0,6] a, used midpint rule with n=5 to estimate intergral form 0 to 10 f(x)dx b, use trapezoidal rule with n=4 to estimate intergral from 1 to 9 f(x)dx c, used simpsons rule with n=4 to estimate intergal from 1 to 9 (x)dx ...
Emmett, L., Ng, A., Ha, L., Russo, R., Mansberg, R., Zhao, W., Chow, V., Kritharides, L. (2012). Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: Myocardial stunning or subendocardial hypoperfusion? Journal of Nuclear Cardiology, 19(4), 735-742. [More Information] ...
The application of a positive end-expiratory pressure (PEEP), the cornerstone of noninvasive ventilation (NIV), causes hemodynamic changes in the cardiovascular system. To understand the benefits of NIV it is necessary to resume concepts of cardiovascular physiology and pathophysiology about cardiac function determinants, venous return, ventricular interdependence and heart-lung interaction, and to understand how PEEP interacts with them. The hemodynamic effects of PEEP are mediated by the increase in transpulmonary pressure, which results in increased pulmonary vascular resistance and in an attending small reduction of venous return in conditions of euvolemia, in a substantial reduction of left ventricular afterload and a potential positive effect on left ventricular stroke volume ...
OBJECTIVES:This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. BACKGROUND:The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or changes in left ventricular ejection fraction. However, the measurement variability of left ventricular ejection fraction necessitates broad diagnostic ranges, with the consequence of low sensitivity for CTRCD. Observational data have shown GLS to be a robust and sensitive marker to predict CTRCD and thereby guide the initiation of cardioprotective therapy, but these data are insufficient to justify changing the diagnostic criteria for CTRCD. METHODS:The SUCCOUR (Strain sUrveillance of Chemotherapy for improving Cardiovascular Outcomes) trial is an international multicenter ...
The value of the end systolic volume depends on the arterial blood pressure as well as on the force of ventricular contraction. The arterial blood pressure - especially in the large arteries leaving the heart - is not only pressure outwards against the arterial walls but also back pressure against the aortic valve and the pulmonary valve exerted by the arterial blood. An increased arterial blood pressure results in higher end systolic volume because of more afterload (more resistance to the outflow of blood from the ventricles). Contractility of the ventricular muscle can increase (e.g. from increased stimulation of the heart by the sympathetic nervous system), thereby causing more complete ejection of blood from the ventricle and a resultant lower end systolic volume. ...
Robert S. McKelvie, MD, PhD, FRCPC, Professor of Medicine, Department of Medicine, McMaster University Hamilton, ON.. Heart failure (HF) is usually associated with reduced left ventricular ejection fraction, but approximately 50% of all patients with HF have a preserved ejection fraction. The mortality and morbidity associated with this condition, which may be the most common form of HF in older persons, is substantial and is on the rise. Currently, there are few evidence-based therapies demonstrated to be beneficial for this condition. The usual therapeutic recommendations consist of the aggressive management of the comorbidities and fluid balance associated with this form of HF. Disease management programs may improve outcomes among older persons with HF and preserved ejection fraction ...
The ejection fraction is a measurement of the hearts efficiency and can be used to estimate the function of the left ventricle, which pumps blood to the rest of the body.. The left ventricle pumps only a fraction of the blood it contains. The ejection fraction is the amount of blood pumped divided by the amount of blood the ventricle contains. A normal ejection fraction is more than 55% of the blood volume. If the heart becomes enlarged, even if the amount of blood being pumped by the left ventricle remains the same, the relative fraction of blood being ejected decreases. For example:. ...
While many cardiac patients focus on their cholesterol level as a measuring stick of their cardiovascular health, they may be overlooking an even more important factor influencing long term survival-their ejection fraction. The ejection fraction (EF) is the percentage of volume of blood that is ejected each cardiac cycle. It is easily measured using simple cardiac tests such as an echocardiogram or MUGA scan. A normal EF should be greater than 50%. Patients who have been diagnosed with congestive heart failure, an enlarged heart or suffered a heart attack may have a significantly lower EF. The ejection fraction is directly proportional to survival; patients with a lower EF have a poorer prognosis. One of the main reasons for reduced survival is that patients with a low EF (, 35%) are at high risk of dying suddenly from rapid unstable cardiac arrhythmias called ventricular tachycardia and ventricular fibrillation. These arrhythmias are unpredictable and often result in sudden death. Sudden death ...
Women with advanced heart failure have better prognosis than men (men versus women HR 2.5, 95% CI 1.1-5.5, p=0.03). Although interaction ischemic heart disease-gender was not significant, HR was 1.6 (95% CI 0.5-5.6, p=0.43) for patients with coronary artery disease and 3.4 (95% CI 1.1-10.5, p=0.03) for patients without.
Stroke volume is a description of the amount of blood the heart pumps. Specifically, it describes the blood volume that a single ventricle discharges with each heartbeat. Stroke volume is often used in the medical field to determine how well a patients heart is functioning. The information required
Patients and methods: Prospective study of 57 pts treated at the Institut Curie between 02/2004 and 01/2007 by concurrent T-RT for non-metastatic BC. The perfusion of trastuzumab started either with or after chemotherapy (CT). RT, started at least 4 weeks after the completion of anthracycline-based chemotherapy, consisted of either whole breast (+/- boost) or chest wall normo-fractionated irradiation. When indicated the internal mammary chain (IMC) and supra/infra-clavicular lymph nodes were also irradiated. Left ventricular ejection fractions (LEVF), assessed at baseline, before start of RT (pre-RT), after completion of RT and then every 4-6 months with either echocardiography or multiple gated acquisition scanning, were considered normal if ≥50% or stated so by the cardiologist. A normal LVEF at baseline was one of the inclusion criteria. Skin toxicity was evaluated using CTCAEV3 ...
TY - JOUR. T1 - α2cDel322-325 and β1Arg389 Adrenergic Polymorphisms Are Not Associated With Reduced Left Ventricular Ejection Fraction or Increased Left Ventricular Volume. AU - Canham, Russell M.. AU - Das, Sandeep R.. AU - Leonard, David. AU - Abdullah, Shuaib M.. AU - Mehta, Sameer K.. AU - Chung, Anne K.. AU - Li, Jia Ling. AU - Victor, Ronald G.. AU - Auchus, Richard J.. AU - Drazner, Mark H.. PY - 2007/1/16. Y1 - 2007/1/16. UR - http://www.scopus.com/inward/record.url?scp=33846029483&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33846029483&partnerID=8YFLogxK. U2 - 10.1016/j.jacc.2006.10.016. DO - 10.1016/j.jacc.2006.10.016. M3 - Article. C2 - 17222742. AN - SCOPUS:33846029483. VL - 49. SP - 274. EP - 276. JO - Journal of the American College of Cardiology. JF - Journal of the American College of Cardiology. SN - 0735-1097. IS - 2. ER - ...
This is as much a statement (and hopefully a reassurance for others in similar situations) as a query. Ive been having moderate PVCs and PACs (mostly isolated, but with occasional couplets and bigemin...
Instantaneous measurement of left and right ventricular stroke volume and pressure-volume relationships with an impedance catheter. Circulation. 1984 Apr; 69(4):703-10 ...
TY - JOUR. T1 - Meta-analysis of Risk of Ventricular Arrhythmias After Improvement in Left Ventricular Ejection Fraction During Follow-Up in Patients With Primary Prevention Implantable Cardioverter Defibrillators. AU - Smer, Aiman. AU - Saurav, Alok. AU - Azzouz, Muhammad Soubhi. AU - Salih, Mohsin. AU - Ayan, Mohamed. AU - Abuzaid, Ahmed. AU - Akinapelli, Abhilash. AU - Kanmanthareddy, Arun. AU - Rosenfeld, Lynda E.. AU - Merchant, Faisal M.. AU - Abuissa, Hussam. PY - 2017/7/15. Y1 - 2017/7/15. N2 - Implantable cardioverter defibrillators (ICDs) reduce the risk of sudden cardiac death in patients with impaired left ventricular ejection fraction (LVEF). However, there are limited data on the long-term benefit of ICD therapy in patients whose LVEF subsequently improves. We conducted a meta-analysis to evaluate the effect of LVEF improvement on ICD therapy during follow-up. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were calculated using random-effects modeling. Sixteen ...
1. Santos AB, Kraigher-Krainer E, Bello N. et al. Left ventricular dyssynchrony in patients with heart failure and preserved ejection fraction. European Heart Journal. 2014;35:42-7 2. Yu CM, Zhang Q, Yip GW. et al. Diastolic and systolic asynchrony in patients with diastolic heart failure: a common but ignored condition. J Am Coll Cardiol. 2007;49:97-105 3. Yusuf S, Pfeffer MA, Swedberg K. et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet. 2003;362:777-81 4. Cleland JG, Tendera M, Adamus J. et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. European Heart Journal. 2006;27:2338-45 5. Massie BM, Carson PE, McMurray JJ. et al. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med. 2008;359:2456-67 6. Morris DA, Vaz Perez A, Blaschke F. et al. Myocardial systolic and diastolic consequences of left ventricular mechanical ...
Background: Obstructive sleep apnea (OSA) occurs when the airway is repeatedly blocked during sleep, resulting in frequent brief awakenings throughout the night. OSA has been found to increase the risk of many cardiovascular diseases, especially heart failure (HF). HF with reduced, preserved, and borderline ejection fraction (HFrEF, HFpEF, and HFbEF) are three subtypes common in OSA patients. The aim of this study is to further explore the relationship between OSA and HF and the influence of specific OSA measures.. Methods: Electronic medical data was collected from health histories, echocardiograms, and polysomnography studies. Observations were sorted into three categories based on left ventricular ejection fraction: HFpEF (n=334), HFrEF (n=77), and HFbEF (n=37). Multinomial logistic regression was then conducted to determine the relative risk of HFpEF and HFrEF from each variable as compared to the baseline HFbEF.. Results: Pacemaker presence, previous stroke, BMI, and a measure of left ...
Fingerprint Dive into the research topics of Clinical outcomes of patients with impaired left ventricular ejection fraction undergoing autologous bone marrow transplantation: Can we safely transplant patients with impaired ejection fraction?. Together they form a unique fingerprint. ...
BACKGROUND Information on the pathophysiological differences between heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF) is needed. OBJECTIVES The purpose of this study was to establish biological pathways specifically related to HFrEF and HFpEF.. METHODS The authors performed a network analysis to identify unique biomarker correlations inHFrEF andHFpEF using 92 biomarkers from different pathophysiological domains in a cohort of 1,544 heart failure (HF) patients. Data were independently validated in 804 patients with HF. Networks were enriched with existing knowledge on protein-protein interactions and translated into biological pathways uniquely related to HFrEF, HF with a midrange ejection fraction, and HFpEF.. RESULTS In the index cohort (mean age 74 years; 34% female), 718 (47%) patients had HFrEF (left ventricular ejection fraction [LVEF] ,40%) and 431 (27%) patients had HFpEF (LVEF ,= 50%). A total of 8 (12%) correlations were ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Robert M. Hansen, Christian E. Viquerat, Michael A. Matthay, Jeanine P. Wiener-Kronish, Teresa DeMarco, Satinder Bahtia, James D. Marks, Elias H. Botvinick, Kanu Chatterjee; Poor Correlation Between Pulmonary Arterial Wedge Pressure and Left Ventricular End-diastolic Volume after Coronary Artery Bypass Graft Surgery. Anesthesiology 1986;64(6):764-770. Download citation file:. ...
Introduction Left ventricular systolic dysfunction and elevated serum interleukins (ILs) are common in septic patients. However, whether left ventricular diastolic dysfunction is related to mortality in septic patients is a matter of debate. Aim The aim of the study was to assess the effect of myocardial systolic and diastolic functions on mortality in cases of sepsis and to predict an inflammatory marker that could be clearly linked to mortality in sepsis. Patients and methods Twenty patients were prospectively studied, with measurement of the following on admission and on day 7: left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction% (echocardiography), mitral annulus S-velocity, Ed/t, and serum levels of ILs (IL-1α, IL-1β, IL-6, and IL-10). Mortality on day 28 was the study endpoint. Results Twenty patients with sepsis and septic shock were studied (45% were male and 55% were female; mean age 52±17 years). The patients were divided ...
Introduction Left ventricular systolic dysfunction and elevated serum interleukins (ILs) are common in septic patients. However, whether left ventricular diastolic dysfunction is related to mortality in septic patients is a matter of debate. Aim The aim of the study was to assess the effect of myocardial systolic and diastolic functions on mortality in cases of sepsis and to predict an inflammatory marker that could be clearly linked to mortality in sepsis. Patients and methods Twenty patients were prospectively studied, with measurement of the following on admission and on day 7: left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction% (echocardiography), mitral annulus S-velocity, Ed/t, and serum levels of ILs (IL-1α, IL-1β, IL-6, and IL-10). Mortality on day 28 was the study endpoint. Results Twenty patients with sepsis and septic shock were studied (45% were male and 55% were female; mean age 52±17 years). The patients were divided ...
Objectives:To evaluate the utility of the right ventricular end-diastolic volume index (RVEDVI) as a method of preload assessment in trauma patients during larg
The lower left ventricular ejection fraction correlated with lower scores on visuospatial, executive function, processing speed/attention and verbal memory capacities (p ≤ 0.05). A higher Gensini score and left atrial size correlated with lower executive function and processing speed/attention (p ≤ 0.05). In the group of patients with an impaired cognitive state, higher Gensini scores correlated with decreased processing speed/attention (p = 0.01) and the e index was associated with lower capacity of executive function (p = 0.05).. ...
To determine the accuracy of visual analysis of left ventricular (LV) function in comparison with the accepted quantitative gold standard method, cardiac magnetic resonance (CMR). Cine CMR imaging was performed at 1.5 T on 44 patients with a range of ejection fractions (EF, 5-80%). Clinicians (n = 18) were asked to visually assess EF after sequentially being shown cine images of a four chamber (horizontal long axis; HLA), two chamber (vertical long axis; VLA) and a short axis stack (SAS) and results were compared to a commercially available analysis package. There were strong correlations between visual and quantitative assessment. However, the EF was underestimated in all categories (by 8.4% for HLA, 8.4% for HLA + VLA and 7.9% for HLA + VLA + SAS, P all | 0.01) and particularly underestimated in mild LV impairment (17.4%, P | 0.01), less so for moderate (4.9%) and not for severe impairment (1%). Assessing more than one view of the heart improved visual assessment of LV, EF, however, clinicians
[reduced ejection fraction (HFrEF) is well-known. Physicians are well versed in diagnosing and treating the disease. At the same time, our knowledge is scarce about heart failure with preserved ejection fraction (HFpEF) and heart failure with mid-ranged ejection fraction (HFmrEF). We are diagnosing these cases in a much lower number than the actual ones, and we have no morbidity and mortality-reducing evidence for treating the disease. The summary is intended to provide an overview of the epidemiology, clinical characteristics, morbidity and mortality, treatment options, the importance of the etiological diagnosis and long-term follow- up of HFmrEF and HFpEF based on currently available literature.]
PubMed journal article: Association of Abnormal Left Ventricular Functional Reserve With Outcome in Heart Failure With Preserved Ejection Fraction. Download Prime PubMed App to iPhone, iPad, or Android
Perioperative goal-directed fluid therapy (GDFT) may improve outcome after high-risk surgery. Minimal invasive measurement of stroke volume variation (SVV) has been recommended to guide fluid therapy. We intended to study how perioperative GDFT with arterial-based continuous SVV monitoring influences postoperative complications in a high-risk surgical population. From February 1st 2012, all ASA 3 and 4 patients undergoing abdominal surgery in two university hospitals were assessed for randomization into a control group or GDFT group. An arterial-line cardiac output monitor was used to measure SVV, and fluid was given after an algorithm in the intervention group. Restrictions of the method excluded patients undergoing laparoscopic surgery, patients with atrial fibrillation and patients with severe mitral/aortal stenosis. To detect a decrease in number of complication from 40 % in the control group to 20 % in the GDFT group, n = 164 patients were needed (power 80 %, alpha 0.05, two-sided test). To include
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Rest images were obtained after intravenous administration of 8 mCi of 99mTc. 25 mCi of 99mTc was injected hours later and after 0.5 mg of sublingual nitroglycerine and rest gated images obtained. Exercise was deferred in view of clinical background of triple vessel disease and severe left ventricular dysfunction. Rest images showed a moderately dilated left ventricle and no pulmonary uptake of tracer. Perfusion abnormality was noted in the inferior wall and inferolateral segments. There was some improvement of perfusion with nitroglycerine. Gated SPECT analysis showed global hyokinesia with a global ejection fraction of about 23%.. ...
Heart failure (HF) is a progressive clinical syndrome caused by the inability of the heart to pump sufficient blood to meet the bodys metabolic needs. HF can result from any disorder that affects the ability of the heart to contract (systolic dysfunction) and relax (diastolic dysfunction). HF with reduced systolic function (i.e., reduced left ventricular ejection fraction, LVEF) is referred to as HF with reduced ejection fraction (HFrEF). Preserved LV systolic function (i.e., normal LVEF) with presumed diastolic dysfunction is termed HF with preserved ejection fraction (HFpEF ...
In contrast to the well-described anatomic and echocardiography abnormalities in patients with GSD II, there is surprisingly little information on LV contractile function in GSD II. De Dominicis et al. (10) reported normal ejection fractions (70% and 68%) measured with echocardiography in two 6-mo-old patients. Bulkley and Hutchins (7) also reported a normal ejection fraction (,70%), measured with LV angiography, in a 5-mo-old girl. In two other case reports (children up to 9 mo of age), invasive assessment of LV function using cardiac catheterization demonstrated normal LV filling pressures (2-3 mmHg), in the presence of severe cardiomegaly (12, 15). In another case report (4 mo of age) normal LV hemodynamics and cardiac index were observed, although early diastolic pressure was elevated with a restrictive LV filling pattern (5). In contrast, markedly elevated LV filling pressures (up to 20 mmHg) and a depressed cardiac index (2.44 l· min−1·m−2) were found in a 4-mo-old child (26). In all ...
The origin of the term ejection fraction is somewhat obscure.[23] After William Harveys description of the basic mechanism of the circulation in 1628, it was initially assumed that the heart emptied completely during systole.[24] However, in 1856 Chauveau and Faivre[25] observed that some fluid remained in the heart after contraction. This was confirmed by Roy and Adami in 1888.[26] In 1906, Henderson[27] estimated the ratio of the volume discharged in systole to the total volume of the left ventricle to be approximately 2/3. In 1933, Gustav Nylin proposed that the ratio of the heart volume/stroke volume (the inverse of ejection fraction) could be used as a measure of cardiac function.[28] in 1952 Bing and colleagues used a minor modification of Nylins suggestion (EDV/SV) to assess right ventricular function using a dye dilution technique.[29] Exactly when the relationship between end diastolic volume and stroke volume was inverted into its current form is unclear. Holt calculated the ratio ...
424 Mobilization of CXCR4+/CD34+ stem cells early in acute myocardial infarction is correlated with left ventricular ejection fraction and NT-proBNP levels after 1 year of follow-up (MRI study). Wojakowski, W.; Wyderka, R.; Maslankiewicz, K.; Ciosek, J.; Ochala, A.; Zebzda, A.; Buszman, P.; Ratajczak, M.Z.; Tendera, M. // European Journal of Heart Failure. Supplements;Jun2006, Vol. 5 Issue 1, p99 An abstract of the study Mobilization of CXCR4+/CD34+ stem cells early in acute myocardial infarction is correlated with left ventricular ejection fraction and NT-proBNP levels after 1 year of follow-up (MRI study), by W. Wojakowski and colleague is presented. ...
TY - JOUR. T1 - Right-Sided Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction and Worsening Renal Function. AU - Mukherjee, Monica. AU - Sharma, Kavita. AU - Madrazo, Jose. AU - Tedford, Ryan J.. AU - Russell, Stuart D.. AU - Hays, Allison. PY - 2017/1/28. Y1 - 2017/1/28. N2 - In urban populations, worsening renal function (WRF) is well established in patients hospitalized with acute decompensated heart failure with preserved ejection fraction (HFpEF). However, the mechanisms for development of WRF in the setting of acute HF in HFpEF are unclear. In the present study, we sought to characterize conventional echocardiographic measures of right ventricular (RV) chamber size and function to determine whether RV dysfunction and/or adverse RV remodeling is related to WRF in patients with HFpEF. Our study included 104 adult patients with HFpEF (EF ≥ 55%) with technically adequate 2-dimensional echocardiograms performed during their hospitalization for acute decompensated HF to ...
TY - JOUR. T1 - Intracardiac echocardiographic measurement of left ventricular volume. AU - Ding, C.. AU - Rao, L.. AU - Nagueh, Sherif. AU - Khoury, D. S.. PY - 2004/12/1. Y1 - 2004/12/1. N2 - We tested the utility of intracardiac echocardiography (ICE) in measuring left ventricular (LV) volume. In 4 normal dogs, a 10-F percutaneous sheath was placed inside the LV along its major axis. An ICE catheter (9 F, 9 MHz) was then inserted through the sheath into the LV. The ICE catheter was pulled back in 1-mm intervals starting from the apex, and 2-D tomographic images were continuously acquired. Subsequently, the ICE catheter was replaced in the LV by a conductance catheter to measure single-beat volume signals. Stroke volume was determined by thermodilution for validation. All measurements were made in each dog while pacing the atrium at two different cycle lengths (range=300-500 ms). The endocardium was segmented in the ICE images throughout the cardiac cycle, and LV volume was computed by ...
Survival from hospital at: 30 days post discharge and 180 days post discharge - Composite endpoint of improved left ventricular regional and global function (both regional wall motion analysis and left ventricular ejection fraction) as measured by echocardiography prior to hospital discharge, survival to discharge and favourable. Left ventricular regional function and left ventricular ejection fraction as measured by echocardiography will be measured prior to discharge or up to 180 days post hospital discharge. ...
Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic myocardial performance is a limiting factor in the generation of SV at HA, we assessed left ventricular (LV) systolic and diastolic mechanics and volumes in 10 healthy participants (aged 32 ± 7; mean ± SD) at rest and during exercise at sea level (SL; 344 m) and after 10 days at 5,050 m. In contrast to SL, LV end-diastolic volume was ∼19% lower at rest (P = 0.004) and did not increase during exercise despite a greater untwisting velocity. Furthermore, resting SV was lower at HA (∼17%; 60 ± 10 vs. 70 ± 8 ml) despite higher LV twist (43%), apical rotation (115%), and circumferential strain (17%). With exercise at HA, the increase in SV was limited (12 vs. 22 ml at SL), and LV apical rotation failed to augment. For the first time, we have demonstrated that EDV does not ...
This is a research study to investigate the effectiveness and safety of a device for patients with heart failure with preserved ejection fraction (HFpEF). Patients with a left ventricular ejection fraction greater than or equal to 40%, symptoms of heart failure and elevated filling pressures on a test called a right heart catheterization may be eligible to enroll. Participation in this multicenter study involves being randomly assigned either to implantation of an Inter Atrial Shunt Device (IASD) System II, or a sham procedure. Participants will be followed by the Tufts Heart Failure Research Team at regular intervals, for a total of 5 years; however they will remain under the care of their usual Cardiologist. The IASD System II consists of a self-expanding metal structure that is placed into the wall between the upper chambers of the heart (right and left atria) to enable blood to move between these chambers. For HFpEF patients with high pressures in the left atrium, it is thought that enabling ...
TY - JOUR. T1 - Time-dependent regional myocardial strains in patients with heart failure with a preserved ejection fraction. AU - Smith, Shane P.. AU - Secomb, Timothy W.. AU - Hong, Brian D.. AU - Moulton, Michael J. PY - 2016. Y1 - 2016. N2 - Objectives. To better understand the etiology of HFpEF in a controlled human population, regional time-varying strains were computed using echocardiography speckle tracking in patients with heart failure with a preserved ejection fraction and normal subjects. Methods. Eleven normal volunteers and ten patients with echo-graded diastolic dysfunction and symptoms of heart failure were imaged with echocardiography and longitudinal, circumferential, and rotational strains were determined using speckle-tracking. Diastolic strain rate was also determined. Patient demographics and echo-derived flows, volumes, and pressures were recorded. Results. Peak longitudinal and circumferential strain was globally reduced in patients (p ,0.001), when compared to controls. ...
Measurements and main results: Demographic, status discharge, EF, morbidity and use of resources were evaluated. Statistical analysis was performed with ANOVA of two ways and χ2. An excellent correlation between EF and mortality, reoperations, acute renal failure, multiorganic dysfunction, cardiorrespiratory arrest, and the use of Swanz-Ganz catheter, intra-aortic ballon counterpulsation, mechanical ventilation, dialysis and blood products was observed ...
Evaluation of the degree of myocardial injury as a result of myocardial necrosis in the acute phase of ST-segment elevation myocardial infarction (STEMI) may be of clinical importance to guide further revascularisation and add important diagnostic and prognostic information in these patients. Left ventricular ejection fraction (LVEF) measured by echocardiography during initial hospitalisation is a well-established marker of LV global function and predicts short- and long-term morbidity and mortality in patients with acute myocardial infarction. However, the measurement of LVEF presents a number of challenges related to image quality, assumptions of LV geometry and high observer variability. Measurement of myocardial deformation by strain has emerged as a promising tool to evaluate regional and global function. The aim of this thesis in clinical cardiology was to investigate the ability of strain to predict myocardial necrosis, LV function and clinical cardiac outcome in patients with acute ...
By combining conventional methods for recording pressures from the left ventricle and pleural cavity with a new procedure for estimating end-diastolic volume (EDV) and end-systolic volume (ESV) of the left ventricle it was found in the closed-chest dog that plethora increased EDV, ESV and stroke volume while hemorrhage had the opposite effect. There were linear relationships between EDV and ESV, and between EDV and stroke volume. There was little change in left ventricular effective end-diastolic pressure when the EDV changed over a wide range, beginning with the smallest EDV consistent with life; but after a certain large EDV had been reached, large increases in effective end-diastolic pressure were associated with little or no further increase in EDV.. ...
Left ventricular ejection fraction (EF) is perhaps the most clinically significant index of global ventricular function. EF is measured in clinical practice using imaging methods such as non-invasive echocardiography. However, imaging methods general
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Ejection fraction is an important measurement in the diagnosis and surveillance of HF. However, it is possible for patients with normal ejection fraction to have HF, and this form of the disease, HF with preserved ejection fraction, or HFpEF, is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging.
Consider pressure-volume loops for heart failure with preserved ejection fraction (HFpEF) diagnosis. PV loops directly demonstrate that patients with HFpEF have an abnormality of passive diastolic properties by measuring their EDPVR.
We discuss Heart Failure with Preserved Ejection Fraction (HFpEF) with Dr. Kavita Sharma, director of the Heart Failure with Preserved Ejection Fraction…
Percentage of patients aged 18 years and older with a diagnosis of coronary artery disease seen within a 12 month period who also have diabetes OR a current or prior Left Ventricular Ejection Fraction (LVEF) | 40% who were prescribed ACE inhibitor or ARB therapy.
A printhead chip for an ink jet printhead includes a substrate. A plurality of nozzle arrangements is positioned on the substrate. Each nozzle arrangement has an active ink ejection structure that is positioned on the substrate and spaced from the substrate. The active ink ejection structure has a roof with an ink ejection port defined in the roof. A static ink ejection structure is positioned on the substrate. The active ink ejection structure and the static ink ejection structure together define a nozzle chamber in fluid communication with an ink supply. The active ink ejection structure is displaceable with respect to the static ink ejection structure towards and away from the substrate to reduce and increase a volume of the nozzle chamber to eject an ink drop from the nozzle chamber. At least two actuators are operatively arranged with respect to the active ink ejection structure to displace the active ink ejection structure with respect to the static ink ejection structure towards and away from the
Robert S. McKelvie, MD, PhD, FRCPC, Professor of Medicine, Department of Medicine, McMaster University Hamilton, ON.. Heart failure (HF) is usually associated with reduced left ventricular ejection fraction, but approximately 50% of all patients with HF have a preserved ejection fraction. The mortality and morbidity associated with this condition, which may be the most common form of HF in older persons, is substantial and is on the rise. Currently, there are few evidence-based therapies demonstrated to be beneficial for this condition. The usual therapeutic recommendations consist of the aggressive management of the comorbidities and fluid balance associated with this form of HF. Disease management programs may improve outcomes among older persons with HF and preserved ejection fraction ...
The product of stroke distance and aortic constant gives stroke volume (how much blood was ejected from a heartbeat into the ... It is minimally invasive (does not break the skin) and is used to derive hemodynamic parameters such as stroke volume (SV) and ... Cardiac output (CO) is the product of stroke volume and heart rate. Although CO is available beat by beat, it is usually ... such as stroke volume (SV), flow-time corrected (FTc) and cardiac output (CO). Using manual input of age, weight and height; ...
Stroke volume (= end-diastolic volume − end-systolic volume) Ejection fraction (= stroke volume / end-diastolic volume) Cardiac ... Suction volume (= end-systolic volume + end-diastolic volume) Injection fraction (=suction volume / end-systolic volume) ... Cardiac output (= heart rate * stroke volume. Can also be calculated with Fick principle.) ... Stroke volume Cardiac output Pressure Pulse pressure (systolic pressure - diastolic pressure) Mean arterial pressure (usually ...
"Effects on cardiac contractility and stroke volume are insignificant." Bainbridge reflex can be blocked by atropine and can be ... Increased blood volume is detected by stretch receptors (Cardiac Receptors) located in both sides of atria at the venoatrial ... In contrast, the Bainbridge reflex responds to changes in blood volume. The Bainbridge reflex is seen in dogs, but experiment ... Increased blood volume results in increased venous return to the heart, which leads to increased firing of B-fibers. B-fibers ...
... is caused by an increased stroke volume.{{cn Müller's sign is named for Friedrich von Müller, a German physician ...
Frazier, J. (2007). "Stroke Volume Variation' Can We Use Fluid to Improve haemodynamics?". Clin. Mark. Edwards Lifesciences. ... Usually for calculating the stroke volume, the methods based on pulse wave analysis need previous and periodic calibrations ... and Stroke Volume (SV). The SV in turn, depends on three general factors: pre-load, post-load and myocardial contractility.[ ... and other hemodynamic parameters such as the Stroke Volume (SV) and Cardiac index (CI). The CO estimated by the qCO monitor is ...
Cardiac output is determined by stroke volume and heart rate; stroke volume is related to myocardial contractility and to the ... Persistent hypertension is a major risk factor for hypertensive heart disease, coronary artery disease, stroke, aortic aneurysm ... The autonomic nervous system plays a central role in maintaining cardiovascular homeostasis via pressure, volume, and ... Another system maintaining the extracellular fluid volume, peripheral resistance, and that if disturbed may lead to ...
The down stroke is preferred because of volume and tone. While this technique of doubling down strokes varies among players, ... Horowitz, Michael (2007), Gypsy Rhythm, Volume 1, Djangobooks.com "Ornamented Arpeggios: Free Jazz Guitar Soloing Lesson 7 by ... the traditional technique is to use a down stroke. For instance, on switching from the G to the B string, the plectrum will ...
Contemporary sources differ on its bore, stroke and swept volume. The first description of the successful machine in Flight ... Output power: bore×stroke: capacity 10-12 hp (7.5-9 kW) 3.35 in × 3.35 in (85 mm × 85 mm): 88.5 cu in (1.45 L) 12-15 hp (9-11 ... but strokes between 120 and 150 mm (4.72 and 5.90 in) are quoted. Most put the output of these engines at about 18 kW (24 hp) ... partly to minimise volume and partly to help cool the hot exhaust valve. Most contemporary and pre-1921 sources agree that the ...
Cardiac output is determined by stroke volume and heart rate; stroke volume is related to myocardial contractility and to the ... When sodium intake exceeds the capacity of the body to excrete it through the kidneys, vascular volume expands secondary to ... The increase in blood volume leads to hypertension. An overactive sympathetic nervous system, leading to increased stress ...
Volume 13 has both pinyin and stroke count indexes, plus appendices. A separate index volume (1997) lists 728,000 entries for ... 2 volumes. 3-volume edition (ISBN 7-5432-0304-9/ISBN 978-7-5432-0015-9): ?th impression (1999-06-01) 2-volume edition (ISBN 7- ... Publication of the thirteen volumes began with first volume in 1986 and ended with the appendix and index volume in 1994. The ... 22 volumes. ?th impression (2008-08-??) 23-volume edition (漢語大詞典) (ISBN 978-7-5326-2782-0): 23 volumes (12+1 index+14 addition ...
Zacharoulis, A. A.; Evans, T. R.; Ziady, G. M.; Coltart, D. J.; Shillingford, J. P. (1975). "Measurement of stroke volume from ... "Effect of respiration on venous return and stroke volume in cardiac tamponade". British Heart Journal. 32 (5): 592-596. doi: ... "John Parsons Shillingford". Munk's Roll, Volume XI, Royal College of Physicians. Shillingford, M. (27 November 1999). "Obituary ...
Cardiac output is the product of stroke volume and heart rate. Afterload is a determinant of stroke volume (in addition to ... the tension upon the muscle fibers in the heart wall is the pressure within the ventricle multiplied by the volume within the ... create a greater tension to overcome the same aortic pressure to eject blood because it has a larger internal radius and volume ...
The stroke center in Heidelberg is a high volume, hyperacute service. Many treatment- and diagnosis related innovations have ... He is a top-ranked author for publications in stroke and stroke therapy both by number and by citations in the last decade. ... In 2020 he received the WSO Leadership in Stroke Award. He is an honorary member of the Austrian and the Hungarian Stroke ... Prof Hacke was the Founding President of the European Stroke Organisation (ESO). He was co-chair of the 2006 World Stroke ...
This type of exercise also increases both heart rate and stroke volume of the heart. Both static and dynamic exercises involve ... The heart becomes enlarged, or hypertrophic, due to intense cardiovascular workouts, creating an increase in stroke volume, an ... It also moderately increases heart rate and stroke volume (oxygen debt). Dynamic exercises include running, swimming, skiing, ... and normal extracellular volume. Athlete's heart is not dangerous for athletes (though if a nonathlete has symptoms of ...
ISBN 978-0-905222-07-3. Casey, Phil (1963-03-05). "Poet Williams Dies of Stroke. Works in 40 Volumes Likened to Chekhov". ... William Carlos Williams, 79, American poet, of a stroke In Camden, Tennessee, country music superstar Patsy Cline (Virginia ... Volume 7: From Nadir Shah to the Islamic Republic (Cambridge University Press, 1991) p753 "Loyola New College Cage Champ", San ...
ISBN 0-321-01556-8 Casey, Phil (1963-03-05). "Poet Williams Dies of Stroke. Works in 40 Volumes Likened to Chekhov". Washington ... Williams suffered a heart attack in 1948, and after 1949, a series of strokes. Severe depression after one such stroke caused ... Later collaborations with artists include the two poem/ two drawing volume that he shared with William Zorach in 1937 and his ... Williams won the first National Book Award for Poetry, recognizing both the third volume of Paterson and Selected Poems. In ...
Aerobic exercise can cause several central cardiovascular adaptations, including an increase in stroke volume (SV)[104] and ... "Physiological outcomes of aerobic exercise training in hemiparetic stroke patients". Stroke: A Journal of Cerebral Circulation ... Without proper rest, the chance of stroke or other circulation problems increases,[82] and muscle tissue may develop slowly. ... volume, and intensity remain to be determined. .... Conclusion. Few interventions exist whereby patients can hope to achieve ...
... reducing maximum volume. Reduced left-heart filling leads to a reduced stroke volume which manifests as a decrease in systolic ... This results in a reduction in left ventricular stroke volume, and will be noted as a reduction in systolic blood pressure in ... This results in a decrease in stroke volume, contributing to the decreased pulse pressure and increased heart rate as described ... Pulsus paradoxus, also paradoxic pulse or paradoxical pulse, is an abnormally large decrease in stroke volume, systolic blood ...
Volume of the stroke, the rotating speed, or the pressure can all be tuned. These different setting are used for different ...
Increased dimensions of the heart enable an individual to achieve a greater stroke volume. A concomitant decrease in stroke ... The amount of oxygen that blood can carry depends on blood volume, which increases during a race, and the amount of hemoglobin ... This is often measured by the volume of oxygen consumed, either in liters or milliliters, per kilogram of body weight per ... however these studies are in conflict with large studies that show longer lifespans for any increase in exercise volume. The ...
The working volume of the intensifier is limited by the stroke of the piston. This in turn limits the amount of work that may ... This design is compact, and again may be made in little over twice the stroke. It has the great advantage though that there is ... A leak of pressure into the volume between the pistons would transform the machine into an effective single piston with equal ... As the pistons are mechanically linked, their force and stroke length are the same. If the diameters are different, the ...
Increased dimensions of the heart enable an individual to achieve a greater stroke volume . A concomitant decrease in stroke ... The initial increase in blood volume during marathon running can later lead to decreased blood volume as a result of increased ... Oxygen affinity of the blood depends on blood plasma volume and an overall decrease in blood volume. Dehydration, temperature ... This is often measured by the volume of oxygen consumed, either in liters or milliliters, per kilogram of body weight per ...
Epo treatment has also shown to preserve hemispheric brain volume 6 weeks after neonatal stroke. It demonstrated both ... This post-stroke neurogenesis was characterized by an impaired migration of neuroblasts in the peri-infarct cortex. This ... Erythropoietin and its receptor have an essential role in neurogenesis, specifically in post-stroke neurogenesis and in the ... "A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery". J. Neurosci. 26 (4): 1269-74. doi:10.1523 ...
The most common cause of a low (narrow) pulse pressure is a drop in left ventricular stroke volume. In trauma, a low or narrow ... A chronically increased stroke volume is also a technical possibility, but very rare in practice.) While some drugs for ... The pulse pressure increases with exercise due to increased stroke volume, healthy values being up to pulse pressures of about ... This behavior facilitates a much greater increase in stroke volume and cardiac output at a lower mean arterial pressure and ...
Among the characteristic features of the artist, is an open color, a textured stroke and volume. The art critic Stanislav ...
This causes a significant increase in output of the left ventricle and increase in stroke volume. Subsequently, calcium channel ...
He completed the final volume just before dying, having previously suffering partial paralysis from a stroke. He was a National ... Aside from his writing, as author and as editor, in volumes related to the People of India survey, Singh also wrote and edited ... The full results of the survey fill 43 published volumes, of which 12 had been produced at the time of Singh's death. The ... A review of the first volume of the series over Contributions to Indian Sociology, noted:- The author claims that the present ...
An increase in contractility tends to increase stroke volume and thus a secondary increase in preload. An increase in preload ...
The reduction in the Windkessel effect results in increased pulse pressure for a given stroke volume. The increased pulse ... Reaching five would be original work.[citation needed] It is assumed that the ratio of pressure to volume is constant and that ... medicine to account for the shape of the arterial blood pressure waveform in terms of the interaction between the stroke volume ... Volumetric inflow must equal the sum of the volume stored in the capacitive element and volumetric outflow through the ...
Apparatus and method for determining an approximation of the stroke volume and the cardiac output of the heart. US Patent No. ... ΔZR is considered an artifact akin to the estimation of stroke volume and is therefore suppressed. Exclusion of derived ... Electrical cardiometry is a method based on the model of Electrical Velocimetry, and non-invasively measures stroke volume (SV ... The general equation for estimating stroke volume by means of thoracic electrical bioimpedance calculates the product of a ...
Hyperosmolar hyperglycemic state, diabetic ketoacidosis, heart disease, strokes, diabetic retinopathy, kidney failure, ... CS1: long volume value. *CS1 maint: multiple names: authors list. *Wikipedia indefinitely semi-protected pages ... strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to ... including ischemic heart disease and stroke; a 20-fold increase in lower limb amputations, and increased rates of ...
FDG-PET imaging of atherosclerosis to detect patients at risk of stroke is also feasible and can help test the efficacy of ... This necessitates frequent recalibration of the remaining dose (determination of activity per unit volume) and careful planning ... then reconstruct the entire volume together (3D). ...
Vein raised above surrounding surface so to be easily felt when stroked with finger. e.g. (see) Pimenta racemosa,[66] ... Verdcourt, Bernard; Bridson, Diane M. (1991). Flora of tropical East Africa - Rubiaceae Volume 3. CRC Press. ISBN 978-90-6191- ... in Rines (1920) Volume XVII. *. James, S. A.; Bell, D. T. (2000). "Influence of light availability on leaf structure and growth ...
Volume one: Human Nature, Volume two: Human Destiny. Reprint editions include: Prentice Hall vol. 1: ISBN 0-02-387510-0, ... "Only a severe stroke prevents me from accepting ... I hope there will be a massive demonstration of all the citizens with ... a b Khurram Hussain, "Tragedy and History in Reinhold Niebuhr's Thought", American Journal of Theology and Philosophy, Volume ... These windmills must have tumbled shortly thereafter for every succeeding volume expresses a more and more explicit revolt ...
CS1: long volume value. *All articles with unsourced statements. *Articles with unsourced statements from August 2020 ...
Brown was incapacitated by a stroke several years ago, and he had suffered from severe arthritis.. .mw-parser-output cite. ... Volume 49, page 1. ...
Volume Two: North African Desert February 1952 - March 1943. London: Grub Street. ISBN 978-1-909166-12-7. .. ... The submarine was powered by two Germaniawerft F46 four-stroke, six-cylinder supercharged diesel engines producing a total of ...
1828-1830: Medical Flora, a Manual of the Medical Botany of the United States of North America (two volumes). Philadelphia. ... 42:"This page of Demotic has letters and numbers, these represented by strokes meaning 5 and dots meaning unities as the dots ... 1836: The American Nations (two volumes). Philadelphia.. *1836: A Life of Travels and Researches in North America and South ... In 1836, Rafinesque published his first volume of The American Nations. This included Walam Olum, a purported migration and ...
Stroke[edit]. Preclinical studies have shown that benzodiazepines can be effective in reducing the effect of strokes for up to ...
Aortic insufficiency is a chronic heart condition that occurs when the aortic valve's initial large stroke volume is released ... Further, that the shape of the meter should be trumpet-shaped in both directions; such a meter will measure volumes flowing in ...
Volume Dois (1998)) "Best band" (1987, 1988, 1989, 1997, 1998), and "Best show" (Titãs - Volume 2 - Ao Vivo, 1998) ... It was a hard stroke to the band, which started recording their new album the day after. A Melhor Banda de Todos os Tempos da ... This record was followed by Volume Dois (1998), modeled in the same way of their unplugged album, only recorded in studio; and ... Volume Dois (1999[50])), "Best show" (Titãs - Acústico MTV, 1998[50]), "Best song" (É Preciso Saber Viver, 1999[50]) and "Best ...
N-Z, Indeks, Volume 1. Psychology Press. pp. 197 ff. ISBN 0415939275.. CS1 maint: Uses editors parameter (link) ... either when it is severed to treat intractable epilepsy or due to a stroke. The standard neurological explanation is that the ... Oxford Handbook of Human Action (Volume 2 of Social Cognition and Social Neuroscience ed.). Oxford University Press. pp. 487 ff ... Oxford Handbook of Human Action (Volume 2 of Social Cognition and Social Neuroscience ed.). Oxford University Press. pp. 487 ff ...
stroke following acute coronary syndrome (clogging of the artery)[note 1][7]:12[29] ... Thomson Gale (Firm), Countries of the World and Their Leaders Yearbook 2007, Volume 1, (Thomson Gale: 2006), p.545. ... Dickens, Charles (1856) [Digitized February 19, 2010]. "The Orsons of East Africa". Household Words: A Weekly Journal, Volume ...
In the adult, the volume of urine in the bladder that normally initiates a reflex contraction is about 300-400 millilitres (11- ... Some paraplegic patients train themselves to initiate voiding by pinching or stroking their thighs, provoking a mild mass ... difference in bladder volume.[11][12] This is due to increased urethra length of large animals, which amplifies gravitational ... At low bladder volumes, afferent firing is low, resulting in excitation of the outlet (the sphincter and urethra), and ...
Tiller JW (1992). "Post-stroke depression". Psychopharmacology. 106 Suppl: S130-3. doi:10.1007/bf02246257. PMID 1546128.. ... moclobemide has an intermediate elimination half life for systemic clearance and an intermediate volume of distribution.[117] ...
StrokeEdit. Music is useful in the recovery of motor skills.[38] In a study on stroke patients in the recovery phase, music ... Kobialka is a type of new age music that produces large volume music that has violins playing over the background of ... M.; Titova, E. Yu.; Kriushev, E. S.; Gamaleya, A. A. (June 8, 2010). "Speech Disorders in Right-Hemisphere Stroke". ... Raglio, Alfredo (January 30, 2017). "Active music therapy approach for stroke patients in the post-acute rehabilitation". ...
In their traditionally popular two-stroke and increasingly popular four-stroke forms, currently produced single cylinder ... of volume, and can be as much as 25 to 30% of the total fuel volume. ... on volume or mass bases) will be higher than hydrocarbon fuels. The extra water produced also makes the charge rather wet ( ... 1 mix of white gas and heavy viscosity motor oil for the two-stroke spark ignition engines used for the hobby at that time. By ...
Four-stroke[edit]. Four-stroke straight-three motorcycle engines have been produced for both road and racing purposes[30] by ... Cycle world, Volume 44. CBS Publications, 2005 *^ Gorant, Jim (December 1997). Oldham, Joe (ed.). "Jet Ski Saviors". Popular ... Cycle world, Volume 44 CBS Publications, 2005. "inline triple" *^ Triumph enters Grand Prix racing as Moto2 engine supplier The ... The smallest inline-three, four-stroke automobile engine was the 543 cubic centimetres (33.1 cu in) Suzuki F5A, which was first ...
Obesity - Volume 1 - HCP 23-I, Third Report of session 2003-04. Report, together with formal minutes. London, UK: TSO (The ... and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants.. ... Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin. Endocrinol. ( ...
The Chinese character for tea is 茶, originally written with an extra stroke as 荼 (pronounced tú, used as a word for a bitter ... Volume 1. South Asia Books. pp. 94-95. ISBN 978-8120604131.. CS1 maint: Uses authors parameter (link) ...
Strokes[edit]. Main article: Stroke (CJK character). Character components can be further subdivided into strokes. The strokes ... Thorp, Robert L. "The Date of Tomb 5 at Yinxu, Anyang: A Review Article," Artibus Asiae (Volume 43, Number 3, 1981): 239-246. ... The radicals are ordered first by stroke count (that is, the number of strokes required to write the radical); within a given ... There are eight basic rules of stroke order in writing a Chinese character: *Horizontal strokes are written before vertical ...
PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum. Reprod. Update. ... an ovarian volume of at least 10 ml is regarded as an acceptable definition of having polycystic ovarian morphology instead of ...
The inlet valves open to admit steam when minimum expansion volume has been reached at the start of the stroke. For a period of ... allowing continued expansion of the steam during the stroke, driving the piston. Near the end of the stroke, the piston will ... Home-made conversions of two-stroke engines[edit]. The single-acting uniflow steam engine configuration closely resembles that ... The inertia of the flywheel then carries the piston back to the top of its stroke against the compression, as it does in the ...
Wilson, Sarah J; Pressing, Jeffrey L; Wales, Roger J (2002). "Modelling rhythmic function in a musician post-stroke". ... and gray matter volume in the primary motor and somatosensory areas, premotor areas, anterior superior parietal areas and in ... Thaut, M. H.; McIntosh, G. C.; Rice, R. R. (1997). "Rhythmic facilitation of gait training in hemiparetic stroke rehabilitation ... rhythmic auditory stimuli have been shown to improve walking ability in Parkinson's disease and stroke patients.[38][39] ...
One theory is that variations in brain size play a role, but the increase in brain volume from edema does not likely cause ... including stroke, intoxication, psychosis,[1] diabetic symptoms, meningitis,[19] or ingestion of toxic substances.[4] It should ...
The plans were delayed after Laurel suffered a stroke on 25 April 1955, from which he recovered. But as the team was planning ... San Bernardino Sun, Volume 44, 7 December 1937, Page 4, "Stan Laurels in Agreement" Accessed 15 April 2017. ... Associated Press, "Surrenders Her Name", The Spokesman-Review, Spokane, Washington, Friday 2 February 1940, Volume 57, Number ... in which Stan visits Oliver Hardy after Hardy has suffered his stroke and tries to say the things to his dying friend and ...
... the forced expiratory volume in one second (FEV1), which is the greatest volume of air that can be breathed out in the first ... They are also associated with increased risk of heart disease and stroke.[136][137] Aclidinium, another long-acting agent, ... For those with very severe disease, surgery is sometimes helpful and may include lung transplantation or lung volume-reduction ... However, his spirometer could measure only volume, not airflow. Tiffeneau and Pinelli in 1947 described the principles of ...
... there is less brain volume in the frontal cortex and temporal lobes, and problems within the corpus callosum, the band of nerve ... A stroke or brain tumor. *A metabolism (chemical reactions keeping the person alive) that is too high or too low ... http://www.kluweronline.com/art.pdf?issn=1386-7423&volume=3&page=153. ...
"U.S. Prime Supplier Sales Volumes of Petroleum Products". Archived from the original on 2 July 2007.. ... two-stroke engines. ... be considered when comparing the fuel efficiency by volume. The ...
Kitani, Osamu, "Volume V: Energy and Biomass Engineering,. CIGR Handbook of Agricultural Engineering", Amer Society of ... Metered pump mixing, petroleum diesel and biodiesel meters are set to X total volume, transfer pump pulls from two points and ...
In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the left ventricle per beat. Stroke volume ... which is stroke volume divided by end-diastolic volume. Because stroke volume decreases in certain conditions and disease ... Stroke volume is an important determinant of cardiac output, which is the product of stroke volume and heart rate, and is also ... Heart rate and Stroke Volume are unfixed. Men, on average, have higher stroke volumes than women due to the larger size of ...
stroke volume: online medical dictionary [home, info] *stroke volume: Medical dictionary [home, info] *Stroke volume, Volume, ... stroke volume: Encyclopedia [home, info] Medicine (6 matching dictionaries). *Stroke volume, Volume, stroke: MedTerms.com ... stroke volume: Merriam-Webster.com [home, info] *stroke volume: Dictionary.com [home, info] *Stroke volume: Wikipedia, the Free ... stroke volume: Dictionary/thesaurus [home, info] Business (2 matching dictionaries). *stroke volume: Legal dictionary [home, ...
Volume 92 - 1st Edition. Print Book & E-Book. ISBN 9780444520036, 9780702035388 ... Purchase Stroke Part I: Basic and epidemiological aspects, ... Stroke Part I: Basic and epidemiological aspects, Volume 92 1st ... Epidemiological implications of primary and secondary stroke prevention. Stroke recurrence and prognosis after stroke. ... This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment ...
White matter hyperintensity volume is increased in small vessel stroke subtypes.. Rost NS1, Rahman RM, Biffi A, Smith EE, ... We determined WMH volume (WMHV) in cohorts of prospectively ascertained patients with acute ischemic stroke (AIS) ( ... Figure 1 Box plot graphic representation of white matter hyperintensity volume distribution by acute ischemic stroke subtype ( ... Greater WMH burden was associated with SV stroke compared with other ischemic stroke subtypes and, even more strongly, with ICH ...
The article presents the possibilities of improvements the crankcase delivery ratio in small two-stroke engines by modification ... of the inlet system by means of an additional side volume connected with the inlet pipe. The results of calculations from ... Citation: Mitianiec, W., "Improvements of Crankcase Delivery Ratio in Two-Stroke Engines with Volume Intake System," SAE ... Improvements of Crankcase Delivery Ratio in Two-Stroke Engines with Volume Intake System 1999-01-3334. ...
... Sladjana Lukic,1,2 Elena Barbieri,1,2 Xue Wang,1, ... This study examined the right hemisphere (RH) grey matter (GM) volume in a group of 40 individuals with stroke-induced chronic ... Few studies have examined GM volume in patients with cognitive impairments resulting from stroke. Stebbins et al. [53], using ... In line with the aforementioned studies showing structural changes after LH stroke, we expected differences in GM volume in the ...
Using the latest brain imaging techniques, Amy and her team will accurately measure brain size in 100 stroke patients over one ... We offer a range of funding across a variety of categories for research into heart, stroke and blood vessel disease. ... They will identify which cardiovascular risk factors are associated with brain atrophy after stroke, and whether cardiovascular ... She is examining modifiable risk factors that may predict brain shrinkage (or atrophy) after a stroke. ...
... voltage between one of the monopolar electrodes in the ventricle and the pacemaker case and for calculating stroke volume ... includes a constant-current source for current injection into the volume of blood in the patients ventricle and an impedance ... A multiple monopolar system and method for measuring stroke volume of a patients heart. An intracardiac impedance catheter is ... measuring the patients stroke volume during said induced variations in heart rate, said step of measuring stroke volume ...
The ratio of stroke volume to pulse pressure (SV/PP) has been proposed as an indirect measure of total arterial compliance,1 2 ... Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension. Giovanni de Simone, Mary J. Roman, Michael ... Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension. Giovanni de Simone, Mary J. Roman, Michael ... Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension. Giovanni de Simone, Mary J. Roman, Michael ...
Eiko No Stroke (3). NADA SHIGEMI 495 yen 4 points (1%) Release Date: Jul 01, 2016(JST) ... Eiko No Stroke (2). NADA SHIGEMI 495 yen 4 points (1%) Release Date: Jul 01, 2016(JST) ... Eiko No Stroke (1). NADA SHIGEMI 495 yen 4 points (1%) Release Date: Jul 01, 2016(JST) ... Eiko He No Shuppatsu (All 3 Volumes) 495 yen Authors. NADA SHIGEMI. ...
Stroke Volume Calculation - If the infection is gentle and considerably localized then to treat toenail fungus a medical doctor ... Read More - Signs Of Heat Stroke In Babies. Hay fever allergies, also recognized as respiratory allergies surprising affects of ... Read More - Ebony Family Strokes. Every single time these antibodies recognize the identical invading allergens histamine is ...
Effect of Natalizumab on Infarct Volume in Acute Ischemic Stroke (ACTION). The safety and scientific validity of this study is ... Change in Infarct Volume From Day 5 (FLAIR) to Day 30 (FLAIR) [ Time Frame: Day 5, Day 30 ]. Relative growth of infarct volume ... Diagnosis of acute ischemic stroke.. *Score of ≥6 points on the National Institute of Health Stroke Scale (NIHSS) at Screening. ... on Reducing Infarct Volume in Acute Ischemic Stroke. ... Change in Infarct Volume From 24 Hours (FLAIR) to Day 5 (FLAIR ...
Simultaneous recordings of beat-to-beat left cardiac stroke volume (SV, pulsed ultrasound Doppler), mean arterial pressure (MAP ... Respiration-synchronous fluctuations in stroke volume, heart rate and arterial pressure in humans J Physiol. 1993 Dec;472:501- ... 1. Simultaneous recordings of beat-to-beat left cardiac stroke volume (SV, pulsed ultrasound Doppler), mean arterial pressure ( ...
Volume 26-4 - 1st Edition. Print Book & E-Book. ISBN 9780323413480, 9780323413497 ... Purchase Stroke Rehabilitaiton, An Issue of Physical Medicine and Rehabilitation Clinics of North America, ... Stroke Rehabilitaiton, An Issue of Physical Medicine and Rehabilitation Clinics of North America, Volume 26-4 1st Edition. ... Mechanisms of stroke recovery, Insights from basic sciences, Stroke recovery and predictors of rehabilitation outcomes, Upper ...
... tidal volume and stroke volume were computed as valley-to-peak values of the RVS and CVS, respectively. The difference in the ... we use the EIT technique to simultaneously measure two global variables of tidal volume and stroke volume. Time-varying ... The difference in the stroke volume data between EIT and TPTD was within ± 4.7 ml from the same animals. The results show the ... The respiratory volume signal (RVS) and cardiac volume signal (CVS) were extracted from reconstructed time-difference EIT ...
Stroke Risk Profile Predicts White Matter Hyperintensity Volume. The Framingham Study. Tom Jeerakathil, Philip A. Wolf, Alexa ... Stroke Risk Profile Predicts White Matter Hyperintensity Volume. Tom Jeerakathil, Philip A. Wolf, Alexa Beiser, Joseph Massaro ... Stroke Risk Profile Predicts White Matter Hyperintensity Volume. Tom Jeerakathil, Philip A. Wolf, Alexa Beiser, Joseph Massaro ... Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke. 1998; 29: 1177-1181. ...
... an immediate fall in stroke volume with the onset of inspiration; and (2) a subsequent increase in stroke volume presumably due ... Pressure-Flow Studies in Man: Effect of Respiration on Left Ventricular Stroke Volume. JEROME RUSKIN, ROBERT J. BACHE, JUDITH C ... In normals, stroke volume, systolic pressure, and pulse pressure fell an average of 7, 3 and 11% (P , 0.01), respectively, ... After breath-holding, stroke volume also fell immediately with the onset of inspiration in both groups. These results are ...
National Stroke Association. Toll Free: 800/787-6537, 303/649-9299 (V). Email: [email protected]stroke.org. www.stroke.org ... Information on type of stroke and individual stroke-related impairment was collected prospectively. Recurrent stroke, ... acute stroke patients and evaluate potential predictors for language outcome 1 year after stroke. METHODS: 270 acute stroke ... Information on stroke and rehabilitation is a common request. In this edition of reSearch, the topic of aphasia and stroke is ...
... cardiac output gradually decreases at the expense of stroke volume.5 The age-related decrease in stroke volume, by reducing ... overcame the effect of the decreasing stroke volume on pulse pressure, explaining the lack of correlation between stroke volume ... without significant influence of stroke volume. Thus, in hypertensive men, the age-related change in stroke volume ... 12 Stroke index was obtained by dividing stroke volume by meters squared. Pulse pressure was calculated as the difference ...
Current Developments in Stroke. Stroke is one of the most debilitating diseases which poses a significant economic burden on ... and air pollution are driving up the worldwide stroke burden. Although medical interventions to prevent and manage stroke have ... Stroke is one of the most debilitating diseases which poses a significant economic burden on society. Increasing exposure to ... This volume should be a useful guide for microbiologists and clinicians interested in designing antimicrobial therapies ...
The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model. Authors. *. E. ... Previous article in issue: Thrombomodulin analogues for the treatment of ischemic stroke Previous article in issue: ... A. P. ANDREOU, J. T. B. CRAWLEY, Thrombomodulin analogues for the treatment of ischemic stroke, Journal of Thrombosis and ... Background: Currently there is no approved anticoagulant for treating acute stroke. This is largely because of concern for ...
Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke. 1998; 29: 1177-1181. ... family history scores for stroke and hypertension to quantitative measures of white-matter hyperintensities and stroke volume ... subcortical and ependymal hyperintense white matter volume. Stroke. 2009; 40: 3685-3690. ... ependymal HWM volume and PP reached statistical significance (LOD=3.19). The linkage results for the subcortical HWM volume ...
... the diastolic volume of the left ventricle minus the volume of blood in the... Explanation of stroke volume ... Find out information about stroke volume. The amount of blood pumped during each cardiac contraction; quantitatively, ... Stroke volume , Article about stroke volume by The Free Dictionary https://encyclopedia2.thefreedictionary.com/stroke+volume ... stroke volume. Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Acronyms, Wikipedia. stroke volume. [′strōk ‚ ...
These cases highlight the severe and unique consequences of coronavirus disease-associated stroke. ... We describe 2 cases in coronavirus disease patients in France involving presumed thrombotic stroke that occurred during ongoing ... anticoagulation treatment for atrial fibrillation stroke prophylaxis; 1 patient had positive antiphospholipid antibodies. ... Volume 26, Number 9-September 2020 Research Letter. Acute Cerebral Stroke with Multiple Infarctions and COVID-19, France, 2020 ...
Title:Annual Report: National Institute Of Neurological Disorders And Stroke Volume 1980 V.2Format:PaperbackDimensions:856 ... Annual Report: National Institute Of Neurological Disorders And Stroke Volume 1980 V.2. byNational Institute Of Neurological ... Customer Reviews of Annual Report: National Institute Of Neurological Disorders And Stroke Volume 1980 V.2. ...
Title:Report Of Program Activities: National Institute Of Neurological Diseases And Stroke Volume 1968/69…Format:Paperback ... Report Of Program Activities: National Institute Of Neurological Diseases And Stroke Volume 1968/69…. byNational Institute Of ... Customer Reviews of Report Of Program Activities: National Institute Of Neurological Diseases And Stroke Volume 1968/69 V.2. ...
stroke volume [ Time Frame: preinduction, 3 and 15 minutes after induction, before and after a volume challenge, 30 minutes ... Validation of Stroke Volume Measurement by a New Noninvasive Hemodynamic Monitoring System (NexFin)in Comparison to Different ... In this study the stroke volume measured by a new noninvasive finger cuff system (NexFin) should be validated in comparison to ... Main hypothesis: there is no difference between stroke volume measurements recorded by a new noninvasive finger cuff system ( ...
In the present study, we aimed to evaluate whether stroke volume variation (SVV) can guide fluid therapy and reduce ... Keywords: central venous pressure, fluid management, lobectomy, one-lung ventilation, stroke volume variation ... Influence of stroke volume variation on fluid treatment and postoperative complications in thoracic surgery Cengiz Sahutoglu, ... The SVV, cardiac output, cardiac index (CI), stroke volume, and stroke volume index (SVI) were measured by the FloTrac Device. ...
In contrast, it is not associated with lacunar stroke, suggesting that the association does not act by promoting small-vessel ... 17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status Stroke ... We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by ... Methods: We quantified WMH on MRI in the stroke-free hemisphere of 2588 ischemic stroke cases. Association between WMHV and 6 ...
Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial. Stroke ... Infarct Volume Predicts Hospitalization Costs in Anterior Circulation Large-Vessel Occlusion Stroke. C.D. Streib, S. Rangaraju ... our Get With The Guidelines stroke data base and our endovascular stroke data base. Patients with acute stroke presenting to ... Acute stroke therapies that reduce final infarct volume may not only improve clinical outcomes but may also prove cost- ...
  • Animal models of ischemic stroke. (elsevier.com)
  • We determined WMH volume (WMHV) in cohorts of prospectively ascertained patients with acute ischemic stroke (AIS) (Massachusetts General Hospital [MGH], n = 628, and the Ischemic Stroke Genetics Study [ISGS], n = 263) and ICH (MGH, n = 122). (nih.gov)
  • Greater WMH burden was associated with SV stroke compared with other ischemic stroke subtypes and, even more strongly, with ICH. (nih.gov)
  • Because atrial fibrillation promotes the formation of blood clots that can travel to the brain and block an artery, atrial fibrillation independently increases the risk of ischemic stroke four-to-five-fold. (elsevier.com)
  • Risk for ischemic stroke has a strong genetic basis, but heritable factors also contribute to the extent of damage after a stroke has occurred. (jci.org)
  • The identification of neuroprotective genes based on naturally occurring allelic variations has the potential to inform the development of drug targets for ischemic stroke treatment. (jci.org)
  • Our data indicate that Solulin is a safe and effective anticoagulant that is able to antagonize active thrombosis in acute ischemic stroke, and to reduce infarct volume. (wiley.com)
  • Several studies have reported that acute ischemic stroke can develop in COVID-19 patients ( 1 - 6 ). (cdc.gov)
  • Cerebral magnetic resonance image (MRI) showing acute ischemic stroke in multiple vascular areas of 2 coronavirus disease patients, France. (cdc.gov)
  • Brain magnetic resonance imaging revealed acute ischemic stroke in multiple vascular areas ( Figure ). (cdc.gov)
  • Several factors can cause acute ischemic stroke, but the primary ones are arterial and cardiac embolism, arterial wall disease, and variants of those conditions. (cdc.gov)
  • We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. (nih.gov)
  • We quantified WMH on MRI in the stroke-free hemisphere of 2588 ischemic stroke cases. (nih.gov)
  • Meta-analyses with previous reports and a genetic risk score approach were applied to identify other novel WMHV risk variants and uncover shared genetic contributions to WMHV in community participants without stroke and ischemic stroke. (nih.gov)
  • Single-nucleotide polymorphisms at 17q25 were associated with WMHV in ischemic stroke, the most significant being rs9894383 (P=0.0006). (nih.gov)
  • A genetic risk score analysis revealed further genetic components to WMHV shared between community participants without stroke and ischemic stroke. (nih.gov)
  • 1 Large-vessel occlusion stroke, one of the most clinically devastating stroke subtypes, is believed to drive acute hospitalization costs in a disproportionate manner relative to other ischemic stroke etiologies. (ajnr.org)
  • Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis. (aace.com)
  • Ischemic strokes were induced in 85 male Sprague-Dawley rats by occluding the middle cerebral artery for 3 hours using an intraluminal filament. (thejns.org)
  • To examine the cost-effectiveness of warfarin sodium and aspirin for prophylaxis of stroke in patients with nonvalvular atrial fibrillation (NVAF), with or without additional risk factors for stroke (previous stroke or transient ischemic attack, diabetes, hypertension, or heart disease). (acpjc.org)
  • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. (acpjc.org)
  • 3680 patients who were ≥ 35 years of age (mean age 66 y, 63% men) and had nondisabling ischemic stroke and elevated total homocysteine (tHcy) levels. (acpjc.org)
  • Recurrent ischemic stroke and coronary heart disease (CHD) events (myocardial infarction [MI] requiring hospitalization, coronary revascularization, cardiac resuscitation, and fatal CHD). (acpjc.org)
  • The high- and low-dose groups did not differ for recurrent ischemic stroke, CHD, or death (Table). (acpjc.org)
  • The identification of the genes underlying these neuroprotective loci will provide new understanding of genetic risk factors of ischemic stroke which may provide novel targets for future therapeutic intervention of human ischemic stroke. (fondationleducq.org)
  • Background Mechanical thrombectomy (MT) is a Level IA treatment in acute ischemic stroke (AIS) patients. (onlinejacc.org)
  • Methods From the ETIS (Endovascular Treatment in Ischemic Stroke) study, a prospective, multicenter, observational real-world MT registry, the authors included all AIS patients consecutively treated by MT between January 2012 and March 2017 in 3 high-volume comprehensive stroke centers by 19 operators. (onlinejacc.org)
  • We studied serum neurofilaments diagnostic value in patients with acute ischemic stroke (AIS) or TIA and evaluated any correlation with symptom severity, cerebral infarction volume, aetiology, and clinical outcome. (quanterix.com)
  • Mokin M, Morr S, Fanous AA, Shallwani H, Natarajan SK, Levy EI, Snyder KV, Siddiqui AH: Correlation Between Cerebral Blood Volume Values and Outcomes in Endovascular Therapy for Acute Ischemic Stroke. (ubns.com)
  • Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke. (semanticscholar.org)
  • BACKGROUND AND PURPOSE The National Institutes of Health Stroke Scale (NIHSS) provides a reliable, quantitative measure of ischemic stroke severity and is predicted by the infarct size. (semanticscholar.org)
  • Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke. (semanticscholar.org)
  • Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke. (semanticscholar.org)
  • A randomized trial of intraarterial treatment for acute ischemic stroke. (semanticscholar.org)
  • Endovascular therapy for ischemic stroke with perfusion-imaging selection. (semanticscholar.org)
  • Randomized assessment of rapid endovascular treatment of ischemic stroke. (semanticscholar.org)
  • Extensive leukoaraiosis is associated with high early risk of recurrence after ischemic stroke. (semanticscholar.org)
  • Khaksar S, Bigdeli M R. Correlation Between Cannabidiol-Induced Reduction of Infarct Volume and Inflammatory Factors Expression in Ischemic Stroke Model. (ac.ir)
  • A consensus working group from numerous international societies has published new guidelines for standards of practice in the treatment of acute ischemic stroke (AIS). (mdedge.com)
  • METHODS: Forty patients diagnosed with acute ischemic stroke and admitted to our clinic within the first 24 hours were accepted into this study. (tjn.org.tr)
  • and (2) a subsequent increase in stroke volume presumably due to an inspiratory increase in right ventricular stroke volume. (ahajournals.org)
  • The effect of reducing the force of right atrial contraction on right ventricular stroke volume was determined in anesthetized open-chest dogs. (ahajournals.org)
  • right ventricular stroke volume was measured with an electro-magnetic flowmeter. (ahajournals.org)
  • This inspiratory reduction in right ventricular stroke volume decreases left ventricular filling after a lag of about two or three beats as blood makes it trip through the pulmonary circuit. (umich.edu)
  • We previously identified a locus on distal mouse chromosome 7 that contributes over 50% of the variation in postischemic cerebral infarct volume observed between inbred strains. (jci.org)
  • Predicting fluid responsiveness with stroke volume variation despite multiple extrasystoles. (biomedsearch.com)
  • To investigate the ability of a new stroke volume variation algorithm to predict fluid responsiveness during general anesthesia and mechanical ventilation in animals with multiple extrasystoles. (biomedsearch.com)
  • Arterial pressure waveforms were recorded and stroke volume variation was computed from the new and from the standard algorithm. (biomedsearch.com)
  • The new stroke volume variation algorithm is designed to restore the respiratory component of the arterial pressure waveform despite multiple ectopic heart beats. (biomedsearch.com)
  • 05), whereas the standard stroke volume variation algorithm was similar in the two groups (29% ± 8% vs. 26% ± 11%, p = .4). (biomedsearch.com)
  • Receiver operating characteristic curve analysis showed that the new stroke volume variation algorithm was an accurate predictor of fluid responsiveness (sensitivity = 86%, specificity = 85%, best cutoff value = 14%, area under the curve = 0.892 ±, whereas the standard stroke volume variation was not (area under the curve = 0.596 ± 0.077). (biomedsearch.com)
  • In contrast to the standard stroke volume variation, the new stroke volume variation algorithm was able to predict fluid responsiveness in animals with multiple ventricular extrasystoles. (biomedsearch.com)
  • Nexfin beat-to-beat arterial blood pressure monitoring enables continuous assessment of hemodynamic indices like cardiac index (CI), pulse pressure variation (PPV) and stroke volume variation (SVV) in the perioperative setting. (springer.com)
  • CO values measured using esCCO and APCO were collected every 6 h, and stroke volume variation (SVV) data were obtained every hour while patients were mechanically ventilated. (springer.com)
  • Stroke volume variation assessed by a FlowTrac transducer and Vigileo monitor and PPV assessed by anaesthesia workstation-integrated monitors showed comparable performance in predicting fluid responsiveness in patients undergoing major surgeries. (thefreedictionary.com)
  • In the present study, we aimed to evaluate whether stroke volume variation (SVV) can guide fluid therapy and reduce complications. (dovepress.com)
  • 2 , 3 As a less invasive hemodynamic monitoring system based on arterial pulse contour analysis, stroke volume variation (SVV) allows continuous monitorization of the fluid status, and several studies have suggested that CVP can be reliably replaced by SVV in the management of fluid therapy. (dovepress.com)
  • Stroke volume variation (SVV) is a good and easily obtainable predictor of fluid responsiveness, which can be used to guide fluid therapy in mechanically ventilated patients. (unboundmedicine.com)
  • TY - JOUR T1 - Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study. (unboundmedicine.com)
  • In this study, we expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume. (fondationleducq.org)
  • Will stroke volume variation be a parameter to manage intraoperative bleeding in the functional endoscopic sinus surgery? (minervamedica.it)
  • Kinoshita H, Kawahito S. Will stroke volume variation be a parameter to manage intraoperative bleeding in the functional endoscopic sinus surgery? (minervamedica.it)
  • Used almost exclusively for patients receiving positive pressure ventilation, stroke volume variation and pulse pressure gauge volume status based on a simple anatomical and physiological connection between the cardiovascular and pulmonary systems. (umich.edu)
  • This is true enough for the most part and as such stroke volume variation and pulse pressure variation can be considered roughly equivalent, especially in the case of their use in assessing volume responsiveness, where they are meant to estimate where along the Frank-Starling curve a patient is (see again Figure 1.5). (umich.edu)
  • Defining the pulse pressure variability as the difference in the maximum and minimum values of the pulse pressure wave normalized to the maximum value ((PPMax − PPMin)/PPMax), it can now serve as a method to gauge volume status, with the mechanism of action and the logic of the approach directly analogous to the stroke volume variation case. (umich.edu)
  • The respiratory induced variation in the waveform is used to determine a subjects volume status. (umich.edu)
  • A meta-analysis of the literature surrounding fluid responsiveness in arterial waveform variations have shown that both stroke volume variation and pulse pressure variation to be highly predictive of fluid responsiveness (with a mean AUC of 0.84 and 0.94, respectively) [60]. (umich.edu)
  • To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using quantitative trait locus (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. (fondationleducq.org)
  • Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion. (semanticscholar.org)
  • CONCLUSIONS: Both methods showed that a 10-mL change in stroke volume during follow-up should be considered as clinically relevant. (biomedsearch.com)
  • Background and Purpose- Previous studies of cardiovascular risk factors and white matter hyperintensity (WMH) on brain MRI have been limited by the failure to exclude symptomatic cerebrovascular disease and dementia or by the use of semiquantitative rather than quantitative methods to measure WMH volume (WMHV). (ahajournals.org)
  • Most large community-based MRI studies examining the relationship between cardiovascular risk factors and WMH have used semiquantitative methods to measure WMH volume (WMHV) on graded ordinal scales. (ahajournals.org)
  • The current study examines the relationship between the Framingham Stroke Risk Profile (FSRP) and individual cardiovascular risk factors and WMHV in a community-based sample of individuals free of stroke and dementia using quantitative MRI methods. (ahajournals.org)
  • Methods- BP measurements and volumes of whole-brain (WB), subcortical, and ependymal HWM lesions, measured from high-resolution (1 mm 3 ) 3-dimensional fluid-attenuated inversion recovery images, served as focal quantitative phenotypes. (ahajournals.org)
  • PATIENTS AND METHODS Children with MCA territory infarcts were selected retrospectively from a database of children with ischaemic stroke. (bmj.com)
  • Present methods for measurement of stroke volume from the aortic pressure pulse are not suitable for beat-to-beat determinations during non-steady state conditions because these methods assume that each systolic ejection is equal to the peripheral runoff during the same beat. (ahajournals.org)
  • Aims: The aim of the study was to investigate whether left ventricular stroke volume (LVSV) assessment using direct measurement of left ventricular outflow tract area (LVOTA) is superior to conventional methods for SV calculation. (diva-portal.org)
  • Stroke volume is calculated using measurements of ventricle volumes from an echocardiogram and subtracting the volume of the blood in the ventricle at the end of a beat (called end-systolic volume ) from the volume of blood just prior to the beat (called end-diastolic volume). (wikipedia.org)
  • Its value is obtained by subtracting end-systolic volume (ESV) from end-diastolic volume (EDV) for a given ventricle. (wikipedia.org)
  • 17 18 19 20 21 22 23 LV end-diastolic and end-systolic volumes were calculated with the Z -derived method, 24 which exhibited a high accuracy for M-mode LV volume calculation even in the presence of dilated LV cavities. (ahajournals.org)
  • SV was calculated in milliliters per beat as end-diastolic minus end-systolic volume and normalized for body surface area (stroke index). (ahajournals.org)
  • 5 The age-related decrease in stroke volume, by reducing pulse pressure, could explain the low proportion of systolic hypertension among middle-aged hypertensive individuals. (ahajournals.org)
  • Results- Bivariate genomewide linkage analyses localized a significant quantitative trait locus influencing WB and regional (ependymal) HWM volumes and pulse pressure and systolic BP to chromosomal location 1q24 between markers D1S196 and D1S1619. (ahajournals.org)
  • The stroke volume is determined by two parameters: the amount of blood in the ventricle before the contraction occurs (end diastolic volume) and the amount left at the end of contraction (end systolic volume). (thefreedictionary.com)
  • A normal left ventricle must contract to eject an adequate stroke volume at a given arterial blood pressure (systolic function), and must fill back without requiring an abnormal increase in left atrial filling pressure (diastolic function)," Dr. (thefreedictionary.com)
  • 1-6 The mechanism of low stroke volume (SV) has been attributed to reduced systemic arterial compliance (SAC), smaller LV cavity size due to concentric remodelling, restrictive physiology resulting in impaired LV filling and diminished LV systolic function despite preserved EF. (bmj.com)
  • SV is the difference between end diastolic volume (EDV) and end systolic volume (ESV). (deltexmedical.com)
  • The total systolic increment (delta PSV) is assumed to describe the pressure-volume characteristics during systole and is related to stroke volume by a constant multiplier that is derived from the indicator-dilution measurements of cardiac output. (ahajournals.org)
  • Although total LV stroke volume is equal in healthy subjects and in clinically compensated heart failure patients with mild LV remodeling, the diastolic routes through the LV and pre-systolic energetics of the SV are significantly different in the two states. (springer.com)
  • It is calculated as the difference between the end-diastolic volume and the end-systolic volume. (rush.edu)
  • 8cm systolic diameter, 22% FS, 117ml diastolic volume , 56.2 ml systolic volume , EF% 52, Stroke Volume 60.8, LVPW thickness .82cm, IVP thickness .88 So, my questions are the following: -Can you have some form of systolic dysfunction without ending up with an enlarged heart or an EF% lower than 50? (medhelp.org)
  • Clinical genetic issues in stroke. (elsevier.com)
  • Advances in our understanding of the biochemical background of strokes, coupled with an examination of breakthroughs in epidemiology, genetics, neuroimaging, interventional radiology, surgery, and even clinical psychology are also explored, giving researchers and clinicians a profoundly altered way to approach stroke research, diagnosis, and patient treatment and care. (elsevier.com)
  • This value can be used to interpret changes in stroke volume during clinical follow-up in PH. (biomedsearch.com)
  • Acute stroke therapies that reduce final infarct volume may not only improve clinical outcomes but may also prove cost-effective. (ajnr.org)
  • In patients with acute stroke who were last known to be well 6 to 24 hours earlier and had a mismatch between clinical deficit and infarction, what are the efficacy and safety of thrombectomy? (annals.org)
  • Randomized controlled trial (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo [DAWN] trial). (annals.org)
  • The aim of our study was to assess the correlation between initial cerebral infarct (CI) volume (quantified on diffusion-weighted MRI) and the resulting clinical outcome in acute stroke patients with middle cerebral artery (MCA) (M(1-2) segment) occlusion detected on MRI angiography treated by intravenous/intraarterial thrombolysis. (nih.gov)
  • Initial infarct volume (V(DWI-I) ) was retrospectively compared with neurological deficit evaluated using the NIH stroke scale on admission and 24 h later, and with the 90-day clinical outcome assessed using the modified Rankin scale in a series of 25 consecutive CI patients. (nih.gov)
  • Clinical outcome could be predicted from initial infarct volume quantified by MRI-DWI in acute CI patients with MCA occlusion treated by intravenous/intraarterial thrombolysis. (nih.gov)
  • AIM To investigate the relation between lesion volume, lesion location, and clinical outcome in children with infarction in the territory of the middle cerebral artery (MCA). (bmj.com)
  • 2 Saunders and colleagues 3 showed recently that measurement of infarct volume on T2 weighted magnetic resonance imaging (MRI) scans taken within 72 hours of stroke predicted clinical outcome in a group of adults with cortical MCA territory infarction. (bmj.com)
  • This study lends formal support to the clinical strategy of anticoagulating patients who are aged 65 to 74 years and are at medium to high risk for stroke. (acpjc.org)
  • 30 patients (63% women) who had clinical evidence of a severe stroke and dysphagia and who were unconscious at hospital admission. (acpjc.org)
  • At this time, it is difficult to establish an evidence-based clinical policy for feeding patients with dysphagia after stroke. (acpjc.org)
  • The VISP trial is the first large RCT evaluating the effect of folic-acid-based multivitamin therapy on such "hard" clinical outcomes as stroke. (acpjc.org)
  • Therefore, health outcomes of stroke treatment vary throughout the world. (eurekaselect.com)
  • See Stroke Volume Optimisation and Improved Outcomes . (deltexmedical.com)
  • Now researchers at Emory University School of Medicine say stroke patients cared for at high volume centers receive faster treatment and fair better with overall outcomes than stroke centers dealing with a lower volume of cases. (emory.edu)
  • This translates to healthier stroke outcomes and better chances of improved functional recovery. (emory.edu)
  • Abstract -Ratio of stroke volume (SV, M-mode echocardiography) to pulse pressure (PP) has been proposed as an estimate of total arterial compliance and has been shown to be related to body size, age, and heart rate in normal adults. (ahajournals.org)
  • Stroke volume is an important determinant of cardiac output, which is the product of stroke volume and heart rate, and is also used to calculate ejection fraction, which is stroke volume divided by end-diastolic volume. (wikipedia.org)
  • Furthermore, to evaluate the possible involvement of an augmented ejection fraction on the increased stroke volume during digestion, we address whether the contractile properties in vitro and enzymatic properties of the ventricles are influenced by digestion. (biologists.org)
  • Impaired function of the systemic RV has been inferred from the almost-uniform findings of increased RV volumes and decreased ejection fraction in midterm survivors. (ahajournals.org)
  • 7 8 However, although one recent study showed a reduction in stroke volume in response to exercise and concluded that this implied ventricular dysfunction, 8 the few available data suggest that measurements of RV volumes and ejection fraction do not predict either functional performance or the likelihood of late deterioration. (ahajournals.org)
  • Left ventricular (LV) volumes and ejection fraction (EF) are important predictors of cardiac morbidity and mortality. (diva-portal.org)
  • Although total left ventricular (LV) stroke volume (SV) is equal in healthy subjects and heart failure patients with mild LV remodeling, the SV's transventricular flow paths to ejection and diastolic energetics are different. (springer.com)
  • The product of average velocity and ejection time gives the stroke distance (how far the blood travels in each heart cycle). (wikipedia.org)
  • Anterior circulation large-vessel occlusion stroke, one of the most devastating stroke subtypes, is associated with substantial economic burden. (ajnr.org)
  • We aimed to identify predictors of increased acute care hospitalization costs associated with anterior circulation large-vessel occlusion stroke. (ajnr.org)
  • Comprehensive cost-tracking software was used to calculate acute care hospitalization costs for patients with anterior circulation large-vessel occlusion stroke admitted July 2012 to October 2014. (ajnr.org)
  • Final infarct volume was the strongest predictor of increased hospitalization costs in anterior circulation large-vessel occlusion stroke. (ajnr.org)
  • Pittsburgh Response to Endovascular therapy (PRE) score: optimizing patient selection for endovascular therapy for large vessel occlusion strokes. (semanticscholar.org)
  • The publication in 2015 of studies showing the efficacy of MT in anterior circulation emergent large-vessel occlusion (ELVO) stroke patients reverberated through the stroke care community, but posed a challenge in delivering this therapy to populations in diverse localities that have no access to level 1 stroke centers. (mdedge.com)
  • Given that, anecdotally, the outcome after ischaemic stroke in childhood is thought to be good, many clinicians would hesitate before instituting potentially hazardous interventions in children. (bmj.com)
  • If there is an association between lesion volume and outcome in children, knowledge of this would be useful in the management of children presenting with acute ischaemic stroke, specifically in targeting groups of children for therapeutic trials. (bmj.com)
  • Concurrently, ischaemic stroke caused by nonvalvular atrial fibrillation (AF) has attracted increasing attention. (biomedcentral.com)
  • The aim of this study was to investigate the association between MPV and the risk of ischaemic stroke in AF patients not receiving anticoagulant therapy. (biomedcentral.com)
  • Patients were divided into a control group and a stroke group according to the presence of ischaemic stroke. (biomedcentral.com)
  • MPV could be a new predictor of ischaemic stroke risk in patients with AF. (biomedcentral.com)
  • Moreover, the CHA2D2S2-VASc combined with MPV can improve predictive value with higher sensitivity and it could be a powerful tool for stratifying patients in terms of ischaemic stroke risk. (biomedcentral.com)
  • Accurate ischaemic stroke risk stratification in atrial fibrillation (AF) patients is an important aspect of AF management. (biomedcentral.com)
  • The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke or transient ischaemic stroke (TIA) or other embolic events, vascular disease, age 65 to 74 years, sex category) score is the most widely used AF-related ischaemic stroke risk stratification tool in the world today. (biomedcentral.com)
  • We explored the risk factors of AF-related ischaemic stroke in the Chinese population and analysed the value of MPV, as well as the CHA2DS2-VASc score combined with MPV, in predicting AF-related ischaemic stroke risk to provide effective guidance for the prevention and management of AF-related ischaemic stroke. (biomedcentral.com)
  • To study the prognostic importance activity of paraoxonase and arylesterase, and the value of mean platelet volume in patients with acute ischaemic stroke. (org.pk)
  • This case-control study was conducted at Harran University Hospital, Sanliurfa, Turkey, from January to June 2014, and comprised patients with symptoms of acute ischaemic stroke who presented to the emergency department. (org.pk)
  • Of the 94 participants, 48(51%) were patients with acute ischaemic stroke and 46(49%) were control subjects. (org.pk)
  • Decreased paraoxonase and arylesterase activity and decreased platelet counts were observed probably due to increased oxidative stress in acute ischaemic stroke patients. (org.pk)
  • Acute ischaemic stroke (AIS) is defined by a combined series of circumstances that develop over hours. (org.pk)
  • 1,2 Moreover, oxidative damage can result in secondary brain injury in ischaemic stroke patients. (org.pk)
  • 9 However, a few studies have specifically examined the platelet (PLT) indices associated with PON1 and arylesterase (ARES) in acute ischaemic stroke patients. (org.pk)
  • RESULTS: After 1 year of treatment, there was, on average, a significant increase in stroke volume and 6MWT. (biomedsearch.com)
  • This leads to an increase of left and right cardiac preload (autotransfusion), with later temporary increase in stroke volume (SV) and cardiac output. (thefreedictionary.com)
  • This observation suggests that the lack of an increase in stroke volume during exercise is not due to the tuna heart operating at maximal anatomical limits. (biologists.org)
  • Conclusions- FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. (ahajournals.org)
  • Conclusions -The stroke volume response to exercise stress is reduced in patients after the Mustard operation. (ahajournals.org)
  • CONCLUSIONS Although the outcome after a small infarct in the MCA territory is variable and unpredictable, infarction of more than 10% of intracranial volume is universally associated with a poor outcome. (bmj.com)
  • Conclusions: SV and CO calculations using direct measurement of LVOT area is a feasible, accurate and reproducible method and correlates extremely well with 3DE volume measurements. (diva-portal.org)
  • Prediction of stroke volume from oxygen pulse measurements in untrained and trained men. (nih.gov)
  • Currently, there is no noninvasive method available for simultaneous measurements of tidal volume and stroke volume. (nature.com)
  • The results show the feasibility of the proposed method as a new noninvasive cardiopulmonary monitoring tool for simultaneous continuous measurements of stroke volume and tidal volume that are two most important vital signs. (nature.com)
  • Simultaneous measurements of stroke volume and tidal volume will enable monitoring of cardiopulmonary functions in an integrated way. (nature.com)
  • We performed bivariate, whole-genome linkage analyses for HWM volumes and BP measurements to identify chromosomal regions that contribute jointly to both traits in a population of healthy Mexican Americans. (ahajournals.org)
  • Our aims were to localize novel quantitative trait loci acting pleiotropically on these phenotypes and to replicate previous genetic findings on whole brain HWM volume and BP measurements. (ahajournals.org)
  • Recent findings by Turner and colleagues 4 have identified overlap between genetic loci for the whole-brain (WB) HWM volume and blood pressure (BP) measurements in 488 hypertensive sibships. (ahajournals.org)
  • In the current article, we pursued to replicate findings by Turner and colleagues 4 using bivariate linkage analysis for WB HWM volume and BP measurements. (ahajournals.org)
  • Measurements included the stroke volume and Left ventricular end-diastolic diameter. (thefreedictionary.com)
  • Blood flow measurements revealed a mean increase in relative cardiac output of 13.6 +/- 3.0% with exercise (mean velocities 1.23-2.10 FLs-1) caused by an 18.8 +/- 5.4% increase in fH and a 3.9 +/- 2.3% decrease in stroke volume. (biologists.org)
  • Each is invasive, requiring either a peripherally or centrally inserted arterial catheter, and each must be calibrated to make use of the pressure-volume conver- sion algorithms in their pulse contour analysis: the FloTrac requires patient information including demographics and physical characteristics and the PiCCO and LiDCO system require indicator dilution cardiac output measurements. (umich.edu)
  • Fernando Pico, Department of Neurology and Stroke Center, Centre Hospitalier de Versailles, 177 Rue de Versailles, Versailles Saint-Quentin en Yvelines et Paris Saclay University, 78150 Le Chesnay, Versailles, France. (onlinejacc.org)
  • Cost-effectiveness of warfarin and aspirin for prophylaxis of stroke in patients with nonvalvular atrial fibrillation. (acpjc.org)
  • Ernesto Goldman, "A Model Simulation for Decreased Left Ventricular Stroke Volume in Obstructive Sleep-Disordered Breathing," ISRN Pulmonology , vol. 2012, Article ID 926345, 5 pages, 2012. (hindawi.com)
  • Decreased left ventricular preload reduces left ventricular stroke volume, doing so at its minimum during the expiratory period. (umich.edu)
  • Clinically significant change in stroke volume in pulmonary hypertension. (biomedsearch.com)
  • BACKGROUND: Stroke volume is probably the best hemodynamic parameter because it reflects therapeutic changes and contains prognostic information in pulmonary hypertension (PH). (biomedsearch.com)
  • Our goal is to estimate the impact of this variability on the EIT-based monitoring of two important central hemodynamic parameters: stroke volume (SV) and pulmonary artery pressure (PAP). (csem.ch)
  • However, one of the drawbacks of TEE compared to pulmonary artery catheters is the inability to measure real time stroke volume (SV) and cardiac output (CO) continuously. (elsevier.com)
  • Centers that perform a large number of endovascular stroke therapies are more efficient and better at it," says Rishi Gupta, MD, associate professor of neurology at Emory University School of Medicine. (emory.edu)
  • Gupta sees patients at the Marcus Stroke and Neuroscience Center at Grady Memorial Hospital - one of the leading centers in the country at rapid treatment and restoration of blood flow to the brain for acute stroke. (emory.edu)
  • This study highlights the importance of patients coming to the hospital quickly with stroke symptoms and centers being quick at achieving restoration of blood flow (reperfusion) as is done with myocardial infarction," says Gupta. (emory.edu)
  • Researcher defined stroke centers as high volume if more than 50 such procedures are carried out a year. (emory.edu)
  • The results of the study are based on the findings from 442 patients treated with endovascular therapy involving clot-busting treatment provided inside the brain via a catheter without the need for surgery at nine stroke centers between September 2009 and July 2011. (emory.edu)
  • the remaining 20 percent were treated at low volume centers. (emory.edu)
  • Patients treated at high volume stroke centers were 86 percent more likely to survive and 82 percent more likely to have blood flow successfully restored in the affected artery. (emory.edu)
  • The new guidelines differ somewhat from the Joint Commission guideline, released in 2015, primarily by raising the bar for the number of mechanical thrombectomy (MT) procedures that level 1 and level 2 stroke centers should perform annually in order to maintain a minimum safety threshold. (mdedge.com)
  • Previous studies have shown lower mortality in high-volume centers, but setting minimum standards can be a challenge, especially in under-served countries and localities. (mdedge.com)
  • The authors, led by first author Laurent Pierot, MD, PhD , of University Hospital Reims (France), acknowledge that newly established level 2 centers may struggle to meet the minimum requirement for MT procedures, but that this is acceptable as long as the volume is expected to meet the minimum within 12-24 months. (mdedge.com)
  • In highly developed countries, stroke centers should follow regional or national guidelines that have higher limits. (mdedge.com)
  • TJC offered no minimum annual procedures for Comprehensive Stroke Centers (equivalent to level 1), and only 15 for Thrombectomy Capable Stroke Centers (level 2), versus 50 in the new guidelines. (mdedge.com)
  • The presence and amount of axonal damage estimated by sNfL correlated with the final cerebral infarction volume but was not predictive of degree of disability. (quanterix.com)
  • OBJECTIVE: In this study, it was aimed to determine the relation between the cerebral infarction volume and common carotid artery (CCA) intima-media thickness (IMT) and internal carotid artery (ICA) intima-media thickness. (tjn.org.tr)
  • The history of stroke and cerebrovascular disease. (elsevier.com)
  • With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder. (elsevier.com)
  • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. (quanterix.com)
  • 2-5 Increases in HWM volume are correlated with a decline in cerebral blood flow, 6 glucose metabolism, 7 and cognition. (ahajournals.org)
  • Acute reductions in ambient temperature at slow swimming velocities resulted in decreases in cardiac output (Q10 = 1.52) and fH (Q10 = 2.16), but increases in stroke volume (Q10 = 0.78). (biologists.org)
  • So a parameter that increases volume will increase blood flow and the stroke volume is increased with an increase in contractility. (medhelp.org)
  • The only way I know of to lower resting heartrate is to strengthen your heart through exercise (it improves the efficiency of your muscles including the heart and also increases the stroke volume of the heart so that you pump more blood with every beat) but I don't know how issues like age, heart disease etc affect that process. (medhelp.org)
  • Because stroke volume decreases in certain conditions and disease states, stroke volume itself correlates with cardiac function. (wikipedia.org)
  • As patients get older, however, cardiac output gradually decreases at the expense of stroke volume. (ahajournals.org)
  • Pregnant patients having a cesarean section (CS) under spinal anesthesia experience a variety of hemodynamic changes, such as hypotension due to decreases in cardiac output (CO), stroke volume (SV) and/or systemic vascular resistance (SVR). (clinicaltrials.gov)
  • The etiology of hypotension is multi-factorial,and it is postulated that decreases in cardiac output (CO), stroke volume (SV) and/or systemic vascular resistance (SVR) may precede decreases in blood pressure. (clinicaltrials.gov)
  • In 7 of 10 experiments, increasing the inhibition of atrial force produced a further decrease in stroke volume. (ahajournals.org)
  • Stroke recurrence and prognosis after stroke. (elsevier.com)
  • Objective Low-gradient (LG) severe aortic stenosis (AS) and preserved EF with reduced stroke volume are associated with an adverse prognosis, but the relationship of stroke volume index (SVI) with mortality among a range of values is unknown. (bmj.com)
  • Finally, some studies have reported that children with a pre-existing medical condition ("symptomatic" stroke) have a worse prognosis than those with apparently "idiopathic" stroke. (bmj.com)
  • In this issue expert authors review drug therapies for stroke prevention, use of the new anticoagulants, ablation strategies for stroke prevention, LAA closure for stroke prevention, stroke in heart rhythm device patients, transesophageal echo in atrial fibrillation, and other topics important to the management of this serious complication. (elsevier.com)
  • The relation between the decrease in atrial force and stroke volume was not altered significantly by the rate of right atrial pacing. (ahajournals.org)
  • Warfarin therapy was cost-effective for prophylaxis of stroke in patients aged 65 years who had nonvalvular atrial fibrillation and at least 1 additional risk factor for stroke. (acpjc.org)
  • Atrial Fibrillation Is Associated With a Worse 90-Day Outcome Than Other Cardioembolic Stroke Subtypes. (semanticscholar.org)
  • White matter hyperintensity volume is increased in small vessel stroke subtypes. (nih.gov)
  • Decreased venous return has the opposite effect, causing a reduction in stroke volume. (wikipedia.org)
  • A promising reduction in stroke volumes is seen. (uwo.ca)
  • Patient demographics and stroke characteristics were analyzed, including final infarct volume on follow-up neuroimaging. (ajnr.org)
  • Final infarct volume, parenchymal hematoma, baseline NIHSS score, ipsilateral carotid stenosis, age, and obstructive sleep apnea were significant predictors of acute care hospitalization costs. (ajnr.org)
  • Final infarct volume alone accounted for 20.87% of the total cost variance. (ajnr.org)
  • Additionally, final infarct volume was consistently the strongest predictor of increased cost in primary, subgroup, and sensitivity analyses. (ajnr.org)
  • Patient selection for stroke endovascular therapy--DWI-ASPECTS thresholds should vary among age groups: insights from the RECOST study. (semanticscholar.org)
  • Mean platelet volume (MPV) has been identified as an individual risk factor for stroke and thrombosis. (biomedcentral.com)
  • In patients with nondisabling cerebral infarction, do high doses of a homocysteine-lowering regimen of pyridoxine, cobalamin, and folic acid prevent stroke recurrence better than low doses of this regimen? (acpjc.org)
  • citation needed] Elevated afterload (commonly measured as the aortic pressure during systole) reduces stroke volume. (wikipedia.org)
  • However, randomized controlled trials (RCTs) have not shown that lowering tHcy (via folic-acid-based multivitamin therapy) reduces stroke. (acpjc.org)
  • Intranasal administration of TGF-β1 reduces infarct volume, improves functional recovery and enhances neurogenesis in mice after stroke. (biomedcentral.com)
  • 1. Simultaneous recordings of beat-to-beat left cardiac stroke volume (SV, pulsed ultrasound Doppler), mean arterial pressure (MAP) and heart rate (HR) were obtained in ten healthy young adults during spontaneous respiration at supine rest, before and after cholinergic blockade by atropine (0.035 mg kg-1). (nih.gov)
  • Influence of respiration on stroke volume determined by impedance cardiography. (semanticscholar.org)
  • Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. (elsevier.com)
  • After 24 h reperfusion, the infarct volume in total, cortex, piriform cortex-amygdala (Pir-Amy), and striatum areas of hemisphere were assessed. (ac.ir)
  • citation needed] Stroke volume is intrinsically controlled by preload (the degree to which the ventricles are stretched prior to contracting). (wikipedia.org)
  • An increase in the volume or speed of venous return will increase preload and, through the Frank-Starling law of the heart, will increase stroke volume. (wikipedia.org)
  • Stroke volume is affected by preload and afterload, according to Cheetah Medical. (reference.com)
  • The combined decrease in preload and increase in afterload causes the stroke volume from the ventricle to decrease, reaching a minimum at the end of inspiration. (umich.edu)
  • It follows, then, that respiratory induced variations in magnitude of ventricular stroke volume indicate should indicate preload dependence [61]. (umich.edu)
  • citation needed] Similar to cardiac index, stroke volume index is a method of relating the stroke volume (SV) to the size of the person Body surface area (BSA). (wikipedia.org)
  • Both exercise and dobutamine infusion were associated with an increase in cardiac index and heart rate and a reduced stroke volume index response. (ahajournals.org)
  • 2011) Role of heart rate and stroke volume during muscle metaboreflex-induced cardiac output increase: differences between activation during and after exercise. (thefreedictionary.com)
  • Results from this study are potentially practice-changing, informing and guiding post-stroke investigations and therapies. (heartfoundation.org.au)
  • Though not usually affecting stroke volume in healthy individuals, increased afterload will hinder the ventricles in ejecting blood, causing reduced stroke volume. (wikipedia.org)
  • Also, increased platelet volume has more active and higher thrombotic potency. (org.pk)
  • In contrast, it is not associated with lacunar stroke, suggesting that the association does not act by promoting small-vessel arteriopathy or the same arteriopathy responsible for lacunar infarction. (nih.gov)
  • In patients with nondisabling cerebral infarction, a multivitamin tablet with high doses of pyridoxine, cobalamin, and folic acid did not differ from a low-dose tablet for reducing recurrent stroke. (acpjc.org)
  • The aim of the present study was to evaluate the effect of cannabidiol on infarction volume and correlation of infarct size with tumor necrosis factor receptor 1 (TNFR1), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) expression. (ac.ir)
  • The present results indicate that in the MCAO-induced cerebral ischemia, administration of cannabidiol (100 and 200 ng) causes a significant reduction in infarction volume in comparison with the vehicle group. (ac.ir)
  • Stroke, carotid arteries, cerebral infarction. (tjn.org.tr)
  • For this reason, stroke volume, which can be measured noninvasively, is an important hemodynamic parameter to monitor during treatment. (biomedsearch.com)
  • It is minimally invasive (does not break the skin) and is used to derive hemodynamic parameters such as stroke volume (SV) and cardiac output (CO). A properly constructed and calibrated probe is approved for use on adults and children in many parts of the world. (wikipedia.org)
  • Slopes (pooled across groups) relating heart rate (.3 bpm/mmHg ), mean arterial pressure (-.16 mmHg/mmHg), and stroke volume (-1.3 ml/mmHg) to the level of LBNP applied were not dependent on decompression rate (all ANOVA comparisons, p ≥ .3). (wku.edu)
  • S V I = S V B S A = ( C O / H R ) B S A = C O H R × B S A {\displaystyle SVI={SV \over BSA}={(CO/HR) \over BSA}={CO \over {HR\times BSA}}} In short, the remaining blood volume left in the left ventricle not pumped out after a systole. (wikipedia.org)
  • quantitatively, the diastolic volume of the left ventricle minus the volume of blood in the ventricle at the end of systole. (thefreedictionary.com)
  • The greater the muscle stretch, the more powerful the contraction during systole and the bigger the volume of blood pumped to the rest of the body. (reference.com)
  • Accuracy of previous estimates for adult prolonged acute mechanical ventilation volume in 2020: Upda. (biomedsearch.com)
  • It is estimated that direct medical costs for stroke treatment in the United States in 2015 reached $38 billion and will rise to $51.3 billion in 2020. (ajnr.org)
  • Stroke aetiology was defined by trial of ORG 10172 in acute stroke treatment classification, severity by National Institute of Health stroke scale (NIHSS) and the degree of disability by the Modified Rankin Scale (mRS) after 90 days. (quanterix.com)
  • Continuous determination of beat to beat stroke volume from aortic pressure pulses in the dog. (ahajournals.org)
  • We have tested a new method which allows determination of an aortic pressure-volume conversion factor over a wide range of pressures during transient changes in stroke volume and infusions of vasoactive drugs in 6 dogs with chronically implanted aortic electromagnetic flowmeters. (ahajournals.org)
  • The values for beat-to-beat variations that were determined by use of the aortic electromagnetic flowmeter and by this aortic pressure pulse method were found to be within the range of measurement errors of stroke volume determined from individual aortic electromagnetic flow pulses. (ahajournals.org)
  • Stroke Volume (SV) is the volume of blood in millilitres ejected from the each ventricle due to the contraction of the heart muscle which compresses these ventricles. (deltexmedical.com)
  • A similar failure to augment stroke volume occurs during dobutamine stress despite appropriate responses in load-independent indexes of contraction and relaxation. (ahajournals.org)
  • Cog-4 has limited diagnostic test accuracy and validity for cognitive assessment in stroke survivors. (semanticscholar.org)
  • Welcome to the ARNI Stroke Charity website for stroke survivors and families: providing specialist rehabilitation and exercise support after hospital and community physiotherapy finishes. (uk.com)