Streptococcus mutans. Medical search

A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.

A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.

Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.

A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.

A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.

Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.

Infections with bacteria of the genus STREPTOCOCCUS.

A species of gram-positive, coccoid bacteria isolated from the human tooth surface. Strains have been shown to be cariogenic in experimental animals and may be associated with human dental caries.

The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.

A bacterium which causes mastitis in cattle and occasionally in man.

The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.

Proteins found in any species of bacterium.

A species of gram-positive, coccoid bacteria commensal in the respiratory tract.

Polysaccharides composed of repeating glucose units. They can consist of branched or unbranched chains in any linkages.

A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener.

A species of gram-positive, coccoid bacteria that is numerous in the mouth and throat. It is a common cause of endocarditis and is also implicated in dental plaque formation.

Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.

A diet that contributes to the development and advancement of DENTAL CARIES.

A species of STREPTOCOCCUS isolated from pigs. It is a pathogen of swine but rarely occurs in humans.

A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.

A genus of gram-positive, rod-shaped bacteria whose organisms are nonmotile. Filaments that may be present in certain species are either straight or wavy and may have swollen or clubbed heads.

A species of gram-positive, coccoid bacteria commonly found in the alimentary tract of cows, sheep, and other ruminants. It occasionally is encountered in cases of human endocarditis. This species is nonhemolytic.

Substances elaborated by specific strains of bacteria that are lethal against other strains of the same or related species. They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria.

Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.

A gram-positive organism found in dental plaque, in blood, on heart valves in subacute endocarditis, and infrequently in saliva and throat specimens. L-forms are associated with recurrent aphthous stomatitis.

Polysaccharides found in bacteria and in capsules thereof.

A species of gram-positive, coccoid bacteria isolated from abscesses in submaxillary glands and mucopurulent discharges of the upper respiratory tract of horses. This organism belongs to Group C streptococci with regards to antigen response and is known to cause strangles. The subspecies S. zooepidemicus is also considered a pathogen of horses.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.

Viruses whose host is Streptococcus.

Substances elaborated by bacteria that have antigenic activity.

The ability of bacterial cells to take up exogenous DNA and be genetically transformed by it.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

The functional hereditary units of BACTERIA.

Process of determining and distinguishing species of bacteria or viruses based on antigens they share.

A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).

A thin protein film on the surface of DENTAL ENAMEL. It is widely believed to result from the selective adsorption of precursor proteins present in SALIVA onto tooth surfaces, and to reduce microbial adherence to the TEETH.

A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.

Substances that promote DENTAL CARIES.

Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Substances that reduce the growth or reproduction of BACTERIA.

The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.

A species of thermophilic, gram-positive bacteria found in MILK and milk products.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)

A group of compounds with the general formula M10(PO4)6(OH)2, where M is barium, strontium, or calcium. The compounds are the principal mineral in phosphorite deposits, biological tissue, human bones, and teeth. They are also used as an anticaking agent and polymer catalysts. (Grant & Hackh's Chemical Dictionary, 5th ed)

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.

Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.

One of a set of bone-like structures in the mouth used for biting and chewing.

The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.

The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.

A property of the surface of an object that makes it stick to another surface.

Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)

Animals not contaminated by or associated with any foreign organisms.

Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

A genus of gram-negative, anaerobic cocci parasitic in the mouth and in the intestinal and respiratory tracts of man and other animals.

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.

Bacterial polysaccharides that are rich in phosphodiester linkages. They are the major components of the cell walls and membranes of many bacteria.

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

Measurable quantity of bacteria in an object, organism, or organism compartment.

Techniques used in studying bacteria.

The clumping together of suspended material resulting from the action of AGGLUTININS.

A natural association between organisms that is detrimental to at least one of them. This often refers to the production of chemicals by one microorganism that is harmful to another.

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Rupture of bacterial cells due to mechanical force, chemical action, or the lytic growth of BACTERIOPHAGES.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The inter- and intra-relationships between various microorganisms. This can include both positive (like SYMBIOSIS) and negative (like ANTIBIOSIS) interactions. Examples include virus - bacteria and bacteria - bacteria.

Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)

A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.

Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.

Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

"Decayed, missing and filled teeth," a routinely used statistical concept in dentistry.

Exotoxins produced by certain strains of streptococci, particularly those of group A (STREPTOCOCCUS PYOGENES), that cause HEMOLYSIS.

Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)

A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharynx flora and has a proclivity for abscess formation, most characteristically in the CENTRAL NERVOUS SYSTEM and LIVER.

Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.

Inflammation of the throat (PHARYNX).

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Bacteria which retain the crystal violet stain when treated by Gram's method.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

The predisposition to tooth decay (DENTAL CARIES).

A species of ACTINOMYCES found in the oral cavity of man and hamsters. It has been isolated from actinomycotic lesions in swine, cats, and dogs and has been identified as a causative agent of animal diseases.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.

Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.

A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

An autolytic enzyme bound to the surface of bacterial cell walls. It catalyzes the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell wall glycopeptides, particularly peptidoglycan. EC 3.5.1.28.

Polysaccharides composed of D-fructose units.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

Process by which micro-organisms adapt quickly to a preferred rapidly-metabolizable intermediate through the inhibition or repression of genes related to CATABOLISM of less preferred source(s).

Nonsusceptibility of an organism to the action of penicillins.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

A tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE.

Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.

The sum of the weight of all the atoms in a molecule.

A resinous substance obtained from beehives that is used traditionally as an antimicrobial. It is a heterogeneous mixture of many substances.

Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.

The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.

Interaction of inflammatory cells and oral microorganisms. II. Modulation of rabbit polymorphonuclear leukocyte hydrolase release by polysaccharides in response to Streptococcus mutans and Streptococcus sanguis. (1/1717)

The release of lysosomal hydrolases from polymorphonuclear leukocytes (PMNs) has been postulated in the pathogenesis of tissue injury in periodontal disease. In the present study, lysosomal enzyme release was monitored from rabbit peritoneal exudate PMNs exposed to Streptocccus mutans or Streptococcus sanguis. S. mutans grown in brain heart infusion (BHI) broth failed to promote significant PMN enzyme release. S. sanguis grown in BHI broth, although more effective than S. mutants, was a weak stimulus for promotion of PMN hydrolase release. Preincubation of washed, viable S. mutans in sucrose or in different-molecular-weight dextrans resulted in the ability of the organisms to provoke PMN release reactions. This effect could bot be demonstrated with boiled or trypsinized S. mutans or with viable S. sanguis. However, when grown in BHI broth supplemented with sucrose, but not with glucose, both S. mutans and S. sanguis triggered discharge of PMN enzymes. The mechanism(s) whereby dextran or sucrose modulates PMN-bacterial interaction may in some manner be related to promotion of microbial adhesiveness or aggregation by dextran and by bacterial synthesis of glucans from sucrose. (+info)

Interaction of inflammatory cells and oral microorganisms. III. Modulation of rabbit polymorphonuclear leukocyte hydrolase release response to Actinomyces viscosus and Streptococcus mutans by immunoglobulins and complement. (2/1717)

In the absence of antiserum, rabbit polymorphonuclear leukocytes (PMNs) released lysosomal enzymes in response to Actinomyces viscosus (19246) but not to Streptococcus mutans (6715). Antibodies had a marked modulating influence on these reactions. PMN hydrolase release was significantly enhanced to both organisms when specific rabbit antiserum and isolated immunoglobulin G (IgG) were included in the incubations. Immune complex F(ab')2 fragments of IgG directed against S. mutans agglutinated bacteria. Immune complexes consisting of S. mutans and F(ab')2 fragments of IgG directed against this organism were not effective as bacteria-IgG complexes in stimulating PMN release. The intensity of the release response to bacteria-IgG complexes was also diminished when PMNs were preincubated with isolated Fc fragments derived from IgG. Fresh serum as a source of complement components had no demonstrable effect on PMN release either alone or in conjuction with antiserum in these experiments. These data may be relevant to the mechanisms and consequences of the interaction of PMNs and plaque bacteria in the pathogenesis of periodontal disease. (+info)

Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model. (3/1717)

Streptococcus mutans, the principal etiologic agent of dental caries in humans, possesses a variety of virulence traits that enable it to establish itself in the oral cavity and initiate disease. A 185-kDa cell surface-localized protein known variously as antigen I/II, antigen B, PAc, and P1 has been postulated to be a virulence factor in S. mutans. We showed previously that P1 expression is necessary for in vitro adherence of S. mutans to salivary agglutinin-coated hydroxyapatite as well as for fluid-phase aggregation. Since adherence of the organism is a necessary first step toward colonization of the tooth surface, we sought to determine what effect deletion of the gene for P1, spaP, has on the colonization and subsequent cariogenicity of this organism in vivo. Germ-free Fischer rats fed a diet containing 5% sucrose were infected with either S. mutans NG8 or an NG8-derived spaP mutant strain, PC3370, which had been constructed by allelic exchange mutagenesis. At 1-week intervals for 6 weeks after infection, total organisms recovered from mandibles were enumerated. At week 6, caries lesions also were scored. A significantly lower number of enamel and dentinal carious lesions was observed for the mutant-infected rats, although there was no difference between parent and mutant in the number of organisms recovered from teeth through 6 weeks postinfection. Coinfection of animals with both parent and mutant strains resulted in an increasing predominance of the mutant strain being recovered over time, suggesting that P1 is not a necessary prerequisite for colonization. These data do, however, suggest a role for P1 in the virulence of S. mutans, as reflected by a decrease in the cariogenicity of bacteria lacking this surface protein. (+info)

The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc. (4/1717)

Mutacin II is a ribosomally synthesized peptide lantibiotic produced by group II Streptococcus mutans. DNA sequencing has revealed that the mutacin II biosynthetic gene cluster consists of seven specific open reading frames: a regulator (mutR), the prepromutacin structural gene (mutA), a modifying protein (mutM), an ABC transporter (mutT), and an immunity cluster (mutFEG). Transformations of a non-mutacin-producing strain, S. mutans UA159, and a mutacin I-producing strain, S. mutans UA140, with chromosomal DNA from S. mutans T8 with an aphIII marker inserted upstream of the mutacin II structural gene yielded transformants producing mutacin II and mutacins I and II, respectively. (+info)

Purification and properties of bacteriolytic enzymes from Bacillus licheniformis YS-1005 against Streptococcus mutans. (5/1717)

To find a novel lytic enzyme against cariogenic Streptococci, strains showing strong lytic activity have been screened from soil using Streptococcus mutans. A strain identified as Bacillus licheniformis secreted two kinds of lytic enzymes, which were purified by methanol precipitation, CM-cellulose chromatography, gel filtration, and hydroxyapatite chromatography. The molecular weights of these two enzymes, L27 and L45, were 27,000 and 45,000, respectively. Optimum pH and temperature of both enzymes for lytic activity were pH 8 and 37 degrees C. L27 and L45 digest the peptide linkage between L-Ala and D-Glu in peptidoglycan of Streptococcus mutans. The lytic activity was highly specific for Streptococcus mutans, suggesting their potential use as a dental care product. (+info)

Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress. (6/1717)

The ability of Streptococcus mutans, a bacterial pathogen associated with dental caries, to tolerate rapid drops in plaque pH (acidurance), is considered an important virulence factor. To study this trait, Tn917 mutants of S. mutans strain JH1005 which display acid sensitivity have been isolated and partially characterized. In this paper, the characterization of one of these mutants, AS17, is reported. Preliminary sequence analysis revealed that the transposon insertion in AS17 occurred in the intergenic region of a two-gene locus which has been named sat for secretion and acid tolerance. This locus displays a high degree of homology to the ylxM-ffh operon of Bacillus subtilis. The sat+ locus was cloned by complementation of a conditional Escherichia coli ffh mutant with an S. mutans genomic library. Sequencing of the complementing clone identified the intact ylxM and ffh genes as well as a partial ORF with homology to the proUlopuAC gene of B. subtilis which encodes the binding protein of the ProU/OpuA osmoregulated glycine betaine transport system. RNA dot blot experiments indicated steady-state levels of ffh mRNA in the mutant that were approximately eightfold lower compared to parental levels. This suggests a partial polar effect of the sat-1::Tn917 mutation on ffh expression. Upon acid shock (pH 5), wild-type ffh mRNA levels were found to increase approximately four- to eightfold compared to unstressed (pH 7.5) levels. Mutant levels remained unaltered under the same conditions. Experiments designed to investigate the origins of the acid-sensitivity of the mutant revealed a lack of an acid-adaptive/tolerance response. Assays of proton-extruding ATPase (H+/ATPase) specific activity measured with purified membranes derived from acid-shocked AS17 showed twofold lower levels compared to the parent strain. Also, AS17 was found to be unable to ferment sorbitol although it was able to grow in glucose and a variety of other sugar substrates. These findings suggest that Ffh may be involved in the maintenance of a functional membrane protein composition during adaptation of S. mutans to changing environmental conditions. (+info)

Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner. (7/1717)

CD14 has been implicated as a receptor of lipoteichoic acid (LTA) and other bacterial components as well as lipopolysaccharide (LPS). Since the structures of LTAs from various gram-positive bacteria are heterogeneous, we analyzed the effects of LTAs on the secretion of interleukin-8 (IL-8) by high- and low-CD14-expressing (CD14(high) and CD14(low)) human gingival fibroblasts (HGF). While Bacillus subtilis LTA had an IL-8-inducing effect on CD14(high) HGF which was considerably weaker than that of LPS, Streptococcus sanguis and Streptococcus mutans LTAs had practically no effect on the cells. B. subtilis LTA had only a weak effect on CD14(low) HGF, as did LPS. S. sanguis and S. mutans LTAs at a 1,000-fold excess each completely inhibited the IL-8-inducing activities of both LPS and a synthetic lipid A on CD14(high) HGF. The effect of LPS was also inhibited by the presence of an LPS antagonist, synthetic lipid A precursor IVA (LA-14-PP), with a 100-fold higher potency than S. sanguis and S. mutans LTAs and by anti-CD14 monoclonal antibody (MAb). S. sanguis and S. mutans LTAs, LA-14-PP, and anti-CD14 MAb had no significant effect on phorbol myristate acetate-stimulated IL-8 secretion by HGF. These LTAs also inhibited the IL-8-inducing activity of B. subtilis LTA on CD14(high) HGF, as did LA-14-PP and anti-CD14 MAb. The antagonistic and agonistic functions of LTAs were also observed with human monocytes. Binding of fluorolabeled LPS to human monocytes was inhibited by S. sanguis LTA, although the inhibition was 100 times weaker than that of LPS itself, and anti-CD14 MAb inhibited fluorolabeled LPS and S. sanguis LTA binding. Binding of LTAs to CD14 was also observed with nondenaturing polyacrylamide gel electrophoresis. These results indicate that LTAs act as antagonists or agonists via a CD14-dependent mechanism, probably due to the heterogeneous structure of LTAs, and that an antagonistic LTA might be a useful agent for suppressing the periodontal disease caused by gram-negative bacteria. (+info)

Humoral immunity to commensal oral bacteria in human infants: salivary secretory immunoglobulin A antibodies reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the first two years of life. (8/1717)

Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci Streptococcus mitis biovar 1 and Streptococcus oralis, the late oral colonizer Streptococcus mutans, and the pioneer enteric bacterium Enterococcus faecalis in saliva samples from 10 human infants from birth to age 2 years were analyzed. Low levels of salivary SIgA1 and SIgA2 antibodies reactive with whole cells of all four species were detected within the first month after birth, even though S. mutans and E. faecalis were not recovered from the mouths of the infants during the study period. Although there was a fivefold increase in the concentration of SIgA between birth and age 2 years, there were no differences between the concentrations of SIgA1 and SIgA2 antibodies reactive with the four species over this time period. When the concentrations of SIgA1 and SIgA2 antibodies reactive with all four species were normalized to the concentrations of SIgA1 and SIgA2 in saliva, SIgA1 and SIgA2 antibodies reactive with these bacteria showed a significant decrease from birth to 2 years of age. Adsorption of each infant's saliva with cells of one species produced a dramatic reduction of antibodies recognizing the other three species. Sequential adsorption of saliva samples removed all SIgA antibody to the bacteria, indicating that the SIgA antibodies were directed to antigens shared by all four species. The induction by the host of a limited immune response to common antigens that are likely not involved in adherence may be among the mechanisms that commensal streptococci employ to persist in the oral cavity. (+info)

"Streptococcus mutans". Encyclopædia Britannica Online. Encyclopædia Britannica. 18 September 2008. Thomas JG, Nakaishi LA ( ... The very initial colonizers of teeth are considered to be Streptococcus, a genus of bacteria that are usually facultative ... O'Sullivan JM, Jenkinson HF, Cannon RD (January 2000). "Adhesion of Candida albicans to oral streptococci is promoted by ... Candida albicans is known to selectively participate in "dual-species" biofilms with certain species of Streptococcus bacteria ...

https://en.wikipedia.org/wiki/Oral_ecology

The most common bacteria associated with dental cavities are the mutans streptococci, most prominently Streptococcus mutans and ... Streptococcus mutans and Lactobacillus species among them. Streptococcus mutans are gram-positive bacteria which constitute ... Streptococcus mutans is the leading cause of tooth decay. Low concentration fluoride ions act as bacteriostatic therapeutic ... and Streptococcus mutans. Bacteria collect around the teeth and gums in a sticky, creamy-coloured mass called plaque, which ...

https://en.wikipedia.org/wiki/Tooth_decay

Streptococcus mutans - a major pathological bacterium - synthesises polysaccharides (glucans) from sucrose to adhere to tooth ... Assev, Synnöve; Rölla, Gunnar (15 August 2009). "Further Studies on the Growth Inhibition of Streptococcus Mutans OMZ 176 by ... Forssten, Sofia D.; Björklund, Marika; Ouwehand, Arthur C. (2 March 2010). "Streptococcus mutans, caries, and simulation models ... "Morphological changes in Streptococcus mutans after chewing gum containing xylitol for twelve months". Current Microbiology. 58 ...

https://en.wikipedia.org/wiki/Xylitol

Shinada, K; Hashizume, L; Teraoka, K; Kurosaki, N (1999). "Effect of ultrasonic toothbrush on Streptococcus mutans". Japan J. ... "Effect of ultrasonic toothbrush on Streptococcus mutans". Japan J. Conserv. Dent. 42 (2): 410-417. US Patent number US5247716, ...

https://en.wikipedia.org/wiki/Ultrasonic_toothbrush

In Streptococcus mutans and other streptococci, transformation is associated with high cell density and biofilm formation. In ... Aspiras MB, Ellen RP, Cvitkovitch DG (September 2004). "ComX activity of Streptococcus mutans growing in biofilms". FEMS ... Streptococcus pneumoniae, transformation is induced by the DNA damaging agent mitomycin C. These, and other, examples indicate ...

https://en.wikipedia.org/wiki/Origin_and_function_of_meiosis

Nicolas, Guillaume G.; Lavoie, Marc C. (January 2011). "[Streptococcus mutans and oral streptococci in dental plaque]". ... Most bacteria cannot use sorbitol for energy, but it can be slowly fermented in the mouth by Streptococcus mutans, a bacterium ...

https://en.wikipedia.org/wiki/Sorbitol

Her postgraduate research was based on Streptococcus mutans. Verran works on the interactions of microorganisms with surfaces ... In vitro studies on the potentially cariogenic properties of certain carbohydrates when incubated with Streptococcus mutans ( ... Effect of two potential sucrose-substitutes upon adherence and sucrose metabolism of Streptoccus mutans (PhD thesis). ...

https://en.wikipedia.org/wiki/Joanna_Verran

Merritt J, Qi F (April 2012). "The mutacins of Streptococcus mutans: regulation and ecology". Molecular Oral Microbiology. 27 ( ... Streptococcus pyogenes has evolved an interwoven complex of gene regulatory mechanisms in the SIP signaling pathway by ... Quorum sensing regulates a menagerie of aspects in Bacillota including the production of ropB-like proteins in Streptococcus ... Similarities in the pH sensitivity of the cell signaling mechanisms were found in pneumococci, S. mutans, and Staphylococcus ...

https://en.wikipedia.org/wiki/RopB_transcriptional_regulator

When the biofilm, containing S. mutans and related oral streptococci, is subjected to acid stress, the competence regulon is ... Biofilm grown S. mutans cells are genetically transformed at a rate 10- to 600-fold higher than S. mutans growing as free- ... Li YH, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG (February 2001). "Natural genetic transformation of Streptococcus mutans ... Senadheera D, Cvitkovitch DG (2008). "Quorum sensing and biofilm formation by Streptococcus mutans". Bacterial Signal ...

https://en.wikipedia.org/wiki/Biofilm

It is present in the Streptococcus mutans plasmid pUA140. The GEBRO motif instance is located in a region of the plasmid DNA in ... a cryptic plasmid from Streptococcus mutans". Plasmid. 46 (2): 77-85. doi:10.1006/plas.2001.1539. PMID 11591133. (Orphaned ... GEBRO motifs are found in some species of Streptococcus. The GEBRO motif is likely associated with plasmids. ...

https://en.wikipedia.org/wiki/GEBRO_RNA_motif

Second, in Streptococcus mutans, there is a strong promoter immediately downstream of the transcription terminator that follows ... Cardineau GA, Curtiss R (March 1987). "Nucleotide sequence of the asd gene of Streptococcus mutans. Identification of the ... The asd motif was detected by bioinformatics and an individual asd RNA in Streptococcus pyogenes was detected by microarray and ... "A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus". PLOS ONE. 4 (11): e7668. Bibcode: ...

https://en.wikipedia.org/wiki/Asd_RNA_motif

... is a bacteriocin produced by Streptococcus mutans. It has activity against a broad spectrum of Gram-positive ...

https://en.wikipedia.org/wiki/Mutacin_1140

Ma, Y; Marquis, RE (November 1996). "Irreversible paraben inhibition of glycolysis by Streptococcus mutans GS-5". Letters in ...

https://en.wikipedia.org/wiki/Paraben

"Antibacterial substances from Albizia myriophylla wood against cariogenic Streptococcus mutans". Archives of Pharmacal Research ...

https://en.wikipedia.org/wiki/Albizia

for Strains Previously Described as Streptococcus mutans Serotype h". International Journal of Systematic Bacteriology. 38 (1 ... "Streptococcus downei" at the Encyclopedia of Life LPSN Type strain of Streptococcus downei at BacDive - the Bacterial Diversity ... Streptococcus downei is a Gram-positive bacterium, with type strain MFe28 (NCTC 11391T). It is thought to be cariogenic. Whiley ... 2005). "First isolation of Streptococcus downei from human dental plaques". FEMS Microbiol Lett. 249 (2): 323-6. doi:10.1016/j. ...

https://en.wikipedia.org/wiki/Streptococcus_downei

Streptococcus mutans (S. mutans) has been identified as the major etiological agent of human dental caries. The development of ... Trials performed in rats showed an increase in antibody response along with a decrease in the amount of Streptococcus mutans ... Martin A. Taubman; Daniel J. Smith (June 1974). "Effects of Local Immunization with Streptococcus mutans on Induction of ... Hillman, Jeffrey D. (August 2002). "Genetically modified Streptococcus mutans for the prevention of dental caries". Antonie van ...

https://en.wikipedia.org/wiki/Caries_vaccine

Yamaguchi, Yasutaka (2008). "Cariogenicity of Three Kinds of Mutans Streptococci from Pig Oral Cavity". Int J Oral-Med Sci. 7 ( ... Streptococcus ferus is a facultatively anaerobic, gram-positive species of the genus Streptococcus. The species is a member of ... mutans S. ferus has not had any reported pathogenic instances in humans. Streptococcus ferus was originally proposed as a ... "BACTERIOLOGY - CHAPTER TWELVE Streptococci GROUPS A, B, D AND OTHERS". Retrieved 11 April 2012. Vos, P.; Garrity, G.; Jones, D ...

https://en.wikipedia.org/wiki/Streptococcus_ferus

"The antibacterial activity of plant extracts containing polyphenols against Streptococcus mutans". Caries Research. 41 (5): 342 ...

https://en.wikipedia.org/wiki/Antibiotic

... -a plant flavonoid as potential antiplaque agent against Streptococcus mutans. GR Prabu, A Gnanamani, S Sadulla, ...

https://en.wikipedia.org/wiki/Guaijaverin

Naradasu, D., et al., Microbial current production from Streptococcus mutans correlates with biofilm metabolic activity. ...

https://en.wikipedia.org/wiki/Microbial_electrochemical_technologies

Streptococcus mutans is the most important bacterium associated with dental caries. Certain bacteria in the mouth live off the ... The microorganisms that form the biofilm are almost entirely bacteria (mainly streptococcus and anaerobes), with the ...

https://en.wikipedia.org/wiki/Human_tooth

Xylitol inhibits Streptococcus mutans in the presence of other sugars, with the exception of fructose. Xylitol is a safe ... Milgrom, P.; Ly, K.A.; Roberts, M.C.; Rothen, M.; Mueller, G.; Yamaguchi, D.K. (2006). "Mutans Streptococci Dose Response to ... Xylitol is specific in its inhibition of Streptococcus mutans, bacteria that are significant contributors to tooth decay. ... "Xylitol Inhibition of Acid Production and Growth of Mutans Streptococci in the Presence of Various Dietary Sugars under ...

https://en.wikipedia.org/wiki/Chewing_gum

... over colony formation and adhesion of Streptococcus mutans. A systematic review and meta-analysis done in a study by Arnold et ... "Are self-ligating brackets related to less formation of Streptococcus mutans colonies? A systematic review". Dental Press ...

https://en.wikipedia.org/wiki/Self-ligating_bracket

"Inhibition of Streptococcus Mutans by Oral Commensal Streptococci and Nitrite-Mediated Activity". {{cite journal}}: Cite ... The main pathogenic bacteria the Scoffield Lab explores are Streptococcus mutans, the major cause of pathogenic oral infection ... doi:10.3390/pathogens8040297 Scoffield JA, Duan D, Zhu F, Wu H. A commensal streptococcus hijacks a Pseudomonas aeruginosa ... doi:10.1099/mic.0.000226 Scoffield JA, Wu H. Oral streptococci and nitrite-mediated interference of Pseudomonas aeruginosa. ...

https://en.wikipedia.org/wiki/Jessica_A._Scoffield

In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from ...

https://en.wikipedia.org/wiki/Thiamine_transporter

One study has shown that macelignan may exert antimicrobial and anticariogenic activity against Streptococcus mutans, but this ... Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. J.Y. Chung, J.H. ...

https://en.wikipedia.org/wiki/Macelignan

"Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level". Journal of Oral Microbiology. 6: ... and Streptococcus sobrinus, but was also effective at inhibiting growth at higher concentrations for other bacterial pathogens ...

https://en.wikipedia.org/wiki/Lactocillin

The bacteria Streptococcus mutans and Streptococcus sanguis cause dental caries by metabolising sugars. Prehistoric primates ...

https://en.wikipedia.org/wiki/Dental_caries_(non-human)

Assev S, Rolla G (1984). "Evidence for presence of a xylitol phosphotransferase system in Streptococcus mutans OMZ 176". Acta ...

https://en.wikipedia.org/wiki/Xylitol_kinase

She has shown that mucins prevent bacteria such as Pseudomonas aeruginosa and Streptococcus mutans, the bacteria that cause ... "Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans". Nature Microbiology. 6 (5 ...

https://en.wikipedia.org/wiki/Katharina_Ribbeck

Does Streptococcus mutans play a prominent role in caries development--and why is the answer important? ... Recovery of S. mutans Smith and Taubman; 1990. Topical. Antibody against GTF; S. mutans to total strep ratios Recolonization ... S. mutans specific IgA; S. mutans to total strep ratios. Ma et al.; 1987. Passive. ... Are the Mutans Streptococci Still Considered Relevant to Understanding the Microbial Etiology of Dental Caries?. ...

https://www.medscape.com/viewarticle/900106_6

... J Indian Soc Pedod Prev Dent ... strains of Streptococcus mutans isolated from human carious teeth. Filter sterilized aqueous extract of garlic was prepared and ... mutans isolated from carious teeth. Of 105 carious teeth tested, 92 (87.6%) isolates of S. mutans were recovered, among which ... Chlorhexidine minimum inhibitory concentration (MIC) for MDR and non-MDR S. mutans varied from 2 to 16 microg ml(-1) and from ...

https://pubmed.ncbi.nlm.nih.gov/18007101/

Streptococcus mutans (2). Description and significance. Streptococcus mutans is a Gram-positive bacterium that lives in the ... S. mutans is considered to be the most cariogenic of all of the oral Streptococci (8). S. mutans was first described by James ... Some virulence factors of S. mutans are found that distinguish S. mutans strains from other oral streptococci isolated from the ... mutans in dental plague and the presence of another bacterim named Streptococcus sanguinis. The study shows that S. mutans ...

https://microbewiki.kenyon.edu/index.php?title=Streptococcus_mutans&direction=next&oldid=64924

An important caries prevention strategy for children includes measures to interfere with transmission of mutans streptococci ( ... Xylitol gum and maternal transmission of mutans streptococci J Dent Res. 2010 Jan;89(1):56-60. doi: 10.1177/0022034509352958. ... An important caries prevention strategy for children includes measures to interfere with transmission of mutans streptococci ( ... Streptococcus mutans / drug effects * Streptococcus mutans / isolation & purification * Sweetening Agents / administration & ...

https://pubmed.ncbi.nlm.nih.gov/19948944/

STREPTOCOCCUS MUTANS (UNII: 5C7J33MJJ1) (STREPTOCOCCUS MUTANS - UNII:5C7J33MJJ1) STREPTOCOCCUS MUTANS. 15 [hp_C] in 1 mL. ... STRE HOMO- enterococcus faecalis, pheumococcinum, streptococcus viridans, streptococcus mutans liquid. Out of scope - Out of ... STRE HOMO- enterococcus faecalis, pheumococcinum, streptococcus viridans, streptococcus mutans liquid. To receive this label ... STREPTOCOCCUS PNEUMONIAE. 15 [hp_X] in 1 mL. STREPTOCOCCUS VIRIDANS GROUP (UNII: NNV2379HKR) (STREPTOCOCCUS VIRIDANS GROUP - ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5fde6841-a176-49a9-b164-77235619488e&audience=professional

... such as Streptococcus mutans, which integrated into a complex dental plaque biofilm on tooth surface. Streptococcus mutans has ... such as Streptococcus mutans, which integrated into a complex dental plaque biofilm on tooth surface. Streptococcus mutans has ... Small Molecule Inhibitors for Streptococcus Mutans Biofilms. Author(s): Qiong Zhang, Lei Cheng, Xuedong Zhou, Jing Zou* and Hui ... Keywords: Oral infectious disease, biofilm, Streptococcus mutans, extracellular polymeric substances, pathogenic microbes, ...

http://www.eurekaselect.com/article/94856

Your search for ENTEROCOCCUS FAECALIS OR STREPTOCOCCUS MUTANS OR STREPTOCOCCUS PNEUMONIAE OR STREPTOCOCCUS VIRIDANS GROUP did ... Did you mean ENTEROCOCCUS fetalis OR STREPTOCOCCUS mutant OR STREPTOCOCCUS PNEUMONIAE OR STREPTOCOCCUS VIRIDANS GROUP? ...

http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=ENTEROCOCCUS+FAECALIS+OR+STREPTOCOCCUS+MUTANS+OR+STREPTOCOCCUS+PNEUMONIAE+OR+STREPTOCOCCUS+VIRIDANS+GROUP

... mutans were made by using, as parents, two serotype c strains that produced unusually large amounts of ethanol, acetic acid, ... Serotype c Streptococcus mutans mutatable to lactate dehydrogenase deficiency S Abhyankar et al. J Dent Res. 1985 Nov. ... Serotype c Streptococcus mutans mutatable to lactate dehydrogenase deficiency S Abhyankar, H J Sandham, K H Chan ... Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans. Xiong K, Chen X, Hu H, Hou H, Gao P, Zou ...

https://pubmed.ncbi.nlm.nih.gov/3912415/

Assessment of the effect of probiotic curd consumption on salivary pH and streptococcus mutans counts * R Sudhir ... Salivary pH and salivary Streptococcus Mutans counts were recorded at baseline and after 30 days and statistically compared ... Keywords: Dental caries, probiotic, curd, salivary pH, streptococcus mutans. Nigerian Medical Journal , Vol. 53 , Issue 3 , ... term consumption of probiotic curd containing Lactobacillus acidophilus and normal curd on salivary Streptococcus Mutans counts ...

https://www.ajol.info/index.php/nmj/article/view/105161

The biofilm inhibitory effect was investigated using Streptococcus mutans UA159 and Candida albicans ATCC 10231. S. mutans was ... Chitosan incorporated in denture base resin reduce biofilm formation of Streptococcus mutans and Candida albicans. Rukke H.V, ... Chitosan incorporated in denture base resin reduce biofilm formation of Streptococcus mutans and Candida albicans. Håkon Valen ... of methacrylated chitosan covalently incorporated into the PMMA network of denture base resin against Streptococcus mutans and ...

https://niom.no/chitosan-in-denture-base-resin/

Streptococci and Actinomyces Inhibit Regrowth of Streptococcus-Mutans on Gnotobiotic Pet Molar Teeth after Chlorhexidine ...

https://repository.ubn.ru.nl/handle/2066/28481

We observed that EGCG inhibited in a dose-dependent manner both the planktonic growth and the biofilm formation of S. mutans. ... Significant reduction of S. mutans biofilm formation, DNA content, and EPS production was observed at 2.2-4.4 mg/ml EGCG. ... EGCG, a natural polyphenol, has a significant inhibitory effect on S. mutans dental biofilm formation and EPS production, and ... mutans) plays a major role in the formation of dental caries. The aim of this study was to examine the effect of the green tea ...

https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01798-4/figures/4

Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this ... Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this ... Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this ... Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this ...

https://nyuscholars.nyu.edu/en/publications/salivary-agglutinin-mediated-adherence-of-streptococcus-mutans-to

... Short- and Long-Term Influence of Fluoride-Containing Prophylactics on the Growth of Streptococcus mutans on Titanium Surface. ...

http://publicatio.bibl.u-szeged.hu/10770/

Streptococcus mutans out-competes Streptococcus gordonii in vivo.. Project description:Streptococcus gordonii and Streptococcus ... A Core Genome Multilocus Sequence Typing Scheme for Streptococcus mutans.. Project description:Streptococcus mutans is one of ... Complete genome sequence of the serotype k Streptococcus mutans strain LJ23.. Project description:Streptococcus mutans is the ... Intracellular alpha-amylase of Streptococcus mutans.. Project description:Sequencing upstream of the Streptococcus mutans gene ...

https://www.omicsdi.org/dataset/omics_ena_project/PRJNA49815

VASCONCELOS, Laurylene César de S. et al. Streptococcus mutans in denture stomatitis patients under antifungal therapy. Rev. ... PURPOSE: To assess the number of Streptococcus mutans in saliva of patients with denture stomatitis before and after antifungal ... RESULTS: The most frequent lesions were type I (43.5%) and II (53.5%). The amount of S. mutans was six times higher in patients ... CONCLUSION: The data suggest that Streptococcus spp collaborates with Candida spp in the etiology and pathogenesis of denture ...

http://revodonto.bvsalud.org/scielo.php?script=sci_abstract&pid=S1980-65232010000200003&lng=es&nrm=iso&tlng=en

We and others have found that c-di-AMP is not essential in Streptococcus mutans, an important etiological agent of dental ... Bacterial Second Messenger Mediated Virulence Regulation in Streptococcus mutans Wu, Hui Oregon Health and Science University, ... An emerging bacterial second messenger c-di-AMP is not only conserved in cariogenic Streptococcus mutans but also found in ... Bacterial Second Messenger Mediated Virulence Regulation in Streptococcus Mutans. Wu, Hui / University of Alabama Birmingham. ...

https://grantome.com/grant/NIH/R01-DE028329-03

A. terreus was found to be effective against all the three strains of S. mutans with zone of growth inhibition ranging between ... by using serial dilution agar plate technique and screened for its antagonistic activity against the three Streptococcus mutans ... Antagonistic Activity of Soil Fungal Metabolite against Streptococcus mutans Strains. Research J. Pharm. and Tech. 3(2): April ... Antagonistic Activity of Soil Fungal Metabolite against Streptococcus mutans Strains. Research J. Pharm. and Tech. 3(2): April ...

https://rjptonline.org/AbstractView.aspx?PID=2010-3-2-9

臺大位居世界頂尖大學之列，為永久珍藏及向國際展現本校豐碩的研究成果及學術能量，圖書館整合機構典藏（NTUR）與學術庫（AH）不同功能平台，成為臺大學術典藏NTU scholars。期能整合研究能量、促

https://scholars.lib.ntu.edu.tw/handle/123456789/305398?mode=simple

Liu, N., Chaudhry, M. T., Xie, Z., Kreth, J., & Merritt, J. (2017). Identification of new degrons in Streptococcus mutans ... Liu, N, Chaudhry, MT, Xie, Z, Kreth, J & Merritt, J 2017, Identification of new degrons in Streptococcus mutans reveals a ... Using the LexA-like regulator HdiR of Streptococcus mutans, we identified two separate N-degrons derived from HdiR that confer ... Using the LexA-like regulator HdiR of Streptococcus mutans, we identified two separate N-degrons derived from HdiR that confer ...

https://ohsu.pure.elsevier.com/en/publications/identification-of-new-degrons-in-streptococcus-mutans-reveals-a-n

Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis ... Genetics and Genomics of the yidC paralogs in Streptococcus mutans Palmer, Sara Marie Raser Ohio State University, Columbus, OH ... Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis ... Streptococcus mutans is the primary etiological agent of dental caries (cavities), a significant contributor to endocarditis, ...

https://grantome.com/grant/NIH/R00-DE023833-04

Effect of Polymer Degree of Conversion on Streptococcus mutans Biofilms. October 5, 2012 ...

https://www.nist.gov/publications/search_by_author/1153416

Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens. Journal of Clinical ... Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens. In: Journal of ... Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens. / Nakano, Kazuhiko; ... Streptococcus mutans was frequently detected in the heart valve (69%) and atheromatous plaque (74%) specimens, while other ...

https://okayama.pure.elsevier.com/en/publications/detection-of-cariogenic-streptococcus-mutans-in-extirpated-heart-

Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth decay). In ... N2 - Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth decay). ... AB - Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth decay). ... abstract = "Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth ...

https://tohoku.pure.elsevier.com/en/publications/cariogenic-streptococcus-mutans-produces-tetramic-acid-strain-spe

A Streptococcus mutans biofilm was grown for 48 h on the restoration surfaces and subsequently evaluated using scanning ... A Streptococcus mutans biofilm was grown for 48 h on the restoration surfaces and subsequently evaluated using scanning ... against Streptococcus mutans and its ability to reduce biofilm formation on standardized experimental Class I restorations in ... against Streptococcus mutans and its ability to reduce biofilm formation on standardized experimental Class I restorations in ...

https://arts.units.it/handle/11368/2720699

Shear stress tolerance of Streptococcus mutans aggregates determined by microfluidic funnel device (μFFD). Authors. Shumi W.; ... Dental caries are initiated by the attachment of Streptococcus mutans aggregates to the surface of teeth. Bacterial adhesion to ... Shear stress tolerance of Streptococcus mutans aggregates determined by microfluidic funnel device (μFFD) ... Herein, we describe a method for determining the effect of shear stress and sucrose on the attachment of S. mutans aggregates ...

https://dspace.ewha.ac.kr/handle/2015.oak/223721

Streptococcus mutans Item Number: (470179-170). Ratings: (No Reviews) REVIEWS (0) Each. ...

https://www.wardsci.com/store/category/live-specimens/13464139?view=list&pageSize=64

Streptococcus mutans.. Dental caries -- Immunological aspects.. Notes:. Includes full text of 5 articles previously published ... Studies of naturally-occurring antibodies to mutans streptococci in humans / Elisabeth Camling.. ...

https://franklin.library.upenn.edu/catalog/FRANKLIN_9913668983503681

... ... Mikroorganisme yang paling dominan menyebabkan karies gigi antara lain Streptococcus mutans dan Lactobacillus. Salah satu cara ... Disimpulkan bahwa berkumur ekstrak lada putih dapat mengurangi jumlah koloni bakteri Streptococcus mutans dan Lactobacillus. ...

http://repository.umy.ac.id/handle/123456789/6820

Inhibitory effects of flavedo, albedo, fruits, and leaves of Citrus unshiu extracts on Streptococcus mutans. Archives of Oral ... Inhibitory effects of flavedo, albedo, fruits, and leaves of Citrus unshiu extracts on Streptococcus mutans. In: Archives of ... Inhibitory effects of flavedo, albedo, fruits, and leaves of Citrus unshiu extracts on Streptococcus mutans. / Nomura, Ryota; ... keywords = "Albedo, Biofilm formation, Citrus unshiu, Dental caries, Streptococcus mutans",. author = "Ryota Nomura and Jumpei ...

https://okayama.pure.elsevier.com/en/publications/inhibitory-effects-of-flavedo-albedo-fruits-and-leaves-of-citrus-

The objective of this study was to compare the effect of short‑term consumption of probiotic curd containing Lactobacillus acidophilus and normal curd on salivary Streptococcus Mutans counts, as well as salivary pH. (ajol.info)
Mikroorganisme yang paling dominan menyebabkan karies gigi antara lain Streptococcus mutans dan Lactobacillus. (umy.ac.id)
Disimpulkan bahwa berkumur ekstrak lada putih dapat mengurangi jumlah koloni bakteri Streptococcus mutans dan Lactobacillus. (umy.ac.id)
Streptococcus mutans , Lactobacillus ) and a diet rich in fermentable carbohydrates, particularly sugars. (cmaj.ca)
Lactobacillus acidophilus, Streptococcus mutans. (thefreedictionary.com)
an indurated gob of polysaccharides and bacteria-eg, Lactobacillus acidophilus , Streptococcus mutans . (thefreedictionary.com)
Some of the most common include Streptococcus mutans, Lactobacillus casei and acidophilus, and Actinomyces naeslundii. (howstuffworks.com)
Several human studies have reported that eating yogurt containing live (viable) probiotic bacteria such as Lactobacillus, Bifidobacterium and Streptococcus thermophilus can significantly reduce risk of tooth cavities and significantly reduce levels of Streptococcus mutans in the mouth. (knowthecause.com)
Lactobacillus paracasei SD1 has been shown to have strong inhibitory effects against Mutans streptococci , making it a good choice as an oral probiotic. (orthodonticproductsonline.com)
Lara-Carrillo E, Montiel-Bastida NM, Sanchez-Perez L, Alanis-Tavira J. Effect of orthodontic treatment on saliva, plaque and the levels of Streptococcus mutans and Lactobacillus. (udea.edu.co)

Streptococcus mutans has been shown to be one of the main pathologic organisms in the initiation and development of dental caries because of the following virulence attributes: producing glucosyltransferases, and synthesizing extracellular polysaccharides, which promote bacterial accumulation and biofilm formation, surviving at a low pH environment and rapidly producing organic acids. (eurekaselect.com)
As the attachment of the cells to a surface is crucial for Streptococcus mutans biofilm formation, it became an attractive target for researchers to design successful small molecule inhibitors. (eurekaselect.com)
Biofilm studies showed that denture base material containing methacrylated chitosan (20 wt%) reduced both biofilm formation of S. mutans and Candida albicans compared to LMW chitosan and control. (niom.no)
Methacrylated chitosan incorporated in a PMMA-based denture resin reduced biofilm formation of S. mutans and Candida albicans. (niom.no)
We and others have found that c-di-AMP is not essential in Streptococcus mutans, an important etiological agent of dental caries (cavity), but regulates cariogenic biofilm formation, bacterial stress responses, and dynamic polymicrobial interactions that are crucial for S. mutans fitness and virulence. (grantome.com)
Influence of MDPB-containing Primer on Streptococcus Mutans Biofilm Formation in Simulated Class I Restorations. (units.it)
Purpose: To evaluate the activity of a methacryloyloxydodecylpyridinium bromide (MDPB)-containing self-etching primer (Clearfil Protect Bond) against Streptococcus mutans and its ability to reduce biofilm formation on standardized experimental Class I restorations in vitro. (units.it)
In addition, Citrus extract was added to the bacterial suspensions of S. mutans MT8148, and inhibitory effects of C. unshiu extracts on MT8148 for antimicrobial activity, bacterial growth, and biofilm formation were analyzed. (elsevier.com)
The aim of this study was to examine the effect of the green tea polyphenol, epigallocatechin gallate (EGCG), on biofilm formation of S. mutans . (biomedcentral.com)
We observed that EGCG inhibited in a dose-dependent manner both the planktonic growth and the biofilm formation of S. mutans . (biomedcentral.com)
Significant reduction of S. mutans biofilm formation, DNA content, and EPS production was observed at 2.2-4.4 mg/ml EGCG. (biomedcentral.com)
EGCG, a natural polyphenol, has a significant inhibitory effect on S. mutans dental biofilm formation and EPS production, and thus might be a potential drug in preventing dental caries. (biomedcentral.com)
The present study aimed to evaluate the in vitro effects of L. reuteri and L. casei on the biofilm formation of major oral pathogens, Streptococcus mutans and Porphyromonas gingivalis . (scidentj.com)
S. mutans ATCC 25175 and P. gingivalis ATCC 33277 were cultured in brain-heart infusion broth and used for biofilm formation on 96-well microplate platform. (scidentj.com)
inhibit growth, biofilm formation and gene expression of caries-inducing Streptococcus mutans. (nih.gov)

[ 8 ] Using a mixed-species plaque model in rats, van der Hoeven and Franken [ 40 ] found that the addition of S. mutans - which attained a plaque representation of 20% -- yielded significantly higher amounts of lactic acid than the mixed-species plaque without S. mutans . (medscape.com)

The objective of present investigation was to study in vitro inhibitory activity of garlic extract on multidrug-resistant (MDR) strains of Streptococcus mutans isolated from human carious teeth. (nih.gov)
Three lactate-dehydrogenase-deficient mutants of serotype c S. mutans were made by using, as parents, two serotype c strains that produced unusually large amounts of ethanol, acetic acid, and acetoin, and very little lactic acid, when grown in broth containing a limiting amount of glucose. (nih.gov)
Acetoin production by wild-type strains and a lactate dehydrogenase-deficient mutant of Streptococcus mutans. (nih.gov)
In the present investigation, a soil fungus was isolated by using serial dilution agar plate technique and screened for its antagonistic activity against the three Streptococcus mutans strains following the overlay culture plate technique and agar well diffusion method. (rjptonline.org)
A. terreus was found to be effective against all the three strains of S. mutans with zone of growth inhibition ranging between 30 and 37mm. (rjptonline.org)
As part of the postdoctoral training of the applicant, an extensive phenotypic characterization was performed on 15 of the sequenced strains, and it was demonstrated that there is substantial diversity in gene content and virulence potential within the species S. mutans. (grantome.com)
In this study, we elucidated the biosynthetic pathway encoded by muc, a hybrid polyketide synthase and nonribosomal peptide synthetase (PKS/NRPS) biosynthetic gene cluster (BGC), present in a number of globally distributed S. mutans strains. (elsevier.com)
Investigations have focused on whether these children harbor more virulent strains of Streptococcus mutans , whether humoral responses differ by racial/ethnic group, and whether varying concentrations of selected salivary innate immunity proteins are associated with different caries outcomes. (nih.gov)
Turns out, there are specific strains of bacteria - streptococcus mutans, in particular - that are more common in mouths with cavities. (ufl.edu)

The genome of S. mutans UA159 , a serotype c strain, has been completely sequenced and is composed of 2,030,936 base pairs. (kenyon.edu)
The biofilm inhibitory effect was investigated using Streptococcus mutans UA159 and Candida albicans ATCC 10231. (niom.no)
However, this approach has not been reported in studies of S. mutans Here, we therefore developed a cgMLST scheme for S. mutans We surveyed 199 available S. mutans genomes as a means of identifying cgMLST targets, developing a scheme that incorporated 594 targets from the S. mutans UA159 reference genome. (omicsdi.org)
2] "Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. (tcdb.org)

The aim of this study was to investigate the biofilm inhibitory effect of methacrylated chitosan covalently incorporated into the PMMA network of denture base resin against Streptococcus mutans and Candida albicans. (niom.no)
The data suggest that Streptococcus spp collaborates with Candida spp in the etiology and pathogenesis of denture stomatitis. (bvsalud.org)
Candida species has been shown to enhance the adherence of S. mutans to the oral biofilm and carious tooth substance. (jiaphd.org)
However, there is a paucity of the literature regarding the association between S. mutans and Candida albicans related to the ECC. (jiaphd.org)
High amounts of sugar in the diet can promote growth of Streptococcus mutans and also promote the growth of the yeast (fungus) Candida in the mouth. (knowthecause.com)

Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this adherence is enhanced by saliva. (nyu.edu)
Salivary agglutinin, a mucinlike glycoprotein known to mediate the aggregation of many oral streptococci in vitro, was found to mediate the adherence of S. mutans to S. sanguis or A. viscosus. (nyu.edu)
Adherence of S. mutans to saliva- or agglutinin-coated S. sanguis and A. viscosus was inhibited by antibodies to the bacterial agglutinin receptor. (nyu.edu)
The results suggest that salivary agglutinin can promote adherence of S. mutans to S. sanguis and A. viscosus through interactions with the agglutinin receptor on S. mutans. (nyu.edu)
S. mutans and C. albicans counts were determined using Mutans-Sanguis agar and CHROMagar, respectively. (jiaphd.org)
Have abused the controlled mutans , Streptococcus sanguis, Porphyromonas. (marketforceanalysis.com)
for example, S mutans and Streptococcus sanguis typically adhere to hard surfaces, while Streptococcus salivarius is found primarily on the tongue. (medscape.com)

The association of S. mutans in dense biofilms on the teeth suggests that S. mutans may affect other plaque bacteria in the mouth. (kenyon.edu)
The present study demonstrated the potential antibiofilm activity of L. casei strain Shirota and L. reuteri ATCC 55730 against S. mutans and P. gingivalis biofilms in vitro . (scidentj.com)
EGCG has been shown in previous studies to fight Streptococcus mutans , which forms biofilms that cause caries. (dentistrytoday.com)

C-di-AMP is essential in many Gram-positive pathogens including Staphylococcus aureus and Streptococcus pneumoniae. (grantome.com)
An emerging bacterial second messenger c-di-AMP is not only conserved in cariogenic Streptococcus mutans but also found in significant pathogens such as Staphylococcus aureus and Streptococcus pneumoniae. (grantome.com)
We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). (cdc.gov)

The aim of the study was to identify the influence of dentifrice containing xylitol on S. mutans serotype E (in vitro). (ui.ac.id)

Inactivation of the gene coding for c-di-AMP producing enzyme reduced bacterial colonization and virulence in a rat model of dental caries, demonstrating a critical role of c-di-AMP in S. mutans virulence. (grantome.com)
While intrapartum antibiotics for Group B streptococcus reduces infant colonization it does not reduce infant mortality. (greenmedinfo.com)
With regard to mother-child relationships, microbiological studies have associated the mother's salivary levels of S. mutans to the degree of colonization and/or caries experience in her children 2 2. (scielo.br)
In a recent study, beta-glucoside metabolism-encoding genes were expressed in Streptococcus gordonii colonization of saliva-coated hydroxyapatite (sHA) and impaired heart valves in rabbits (2). (kenyon.edu)
However, fixed and removable orthodontic appliances that help correct problems facilitate the colonization of bacteria, such as Mutans streptococci . (orthodonticproductsonline.com)

In fact, earlier studies have shown that there is an inverse relationship between the quantity of S. mutans in dental plague and the presence of another bacterim named Streptococcus sanguinis . (kenyon.edu)
Wild-type A12, but not an sgc mutant derivative, could protect the sensitive indicator strain Streptococcus sanguinis SK150 from killing by the bacteriocins of S. mutans. (omicsdi.org)

To assess the number of Streptococcus mutans in saliva of patients with denture stomatitis before and after antifungal therapy. (bvsalud.org)
Studies have shown a higher risk of caries because of lower pH of saliva, reduced salivary buffering capacity, sugar added to tobacco by manufacturers and high number of lactobacilli and Streptococcus mutans in the mouths of tobacco users (3,4). (who.int)
This study aims to observe the change in the pH of saliva and to assess the efficacy of the herbal rinses-Tulsi and Black myrobalans on S. mutans count while comparing it with Sodium fluoride mouthrinse. (fluoridealert.org)

Levels of salivary Mutans streptococci and lactobacilli were measured at the start of the study and once a week for 4 weeks after use of the probiotic concluded. (orthodonticproductsonline.com)

Universal screening and antibiotic prophylaxis of all group B streptococcus carriers result in increased antibiotic exposure in our population, which might carry its own risks. (greenmedinfo.com)
False-positive detection of Group B Streptococcus (GBS) in chromogenic media (Strep B Carrot Broth) due to presence of Enterococcus faecalis in High Vaginal swabs. (amedeo.com)
Group B Streptococcus (GBS) or Streptococci agalactiae is one of the serologically distinct species of genus streptococcus which colonizes genitourinary and lower gastrointestinal tracts of female populations. (researchsquare.com)

Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis and is strongly associated with cardiovascular disease and stroke. (grantome.com)
Streptococcus mutans is the primary etiological agent of dental caries (cavities), a significant contributor to endocarditis, and has recently been associated with atherosclerosis and stroke. (grantome.com)

Streptococcus mutans is a common constituent of dental plaque and a major etiologic agent of dental caries (tooth decay). (elsevier.com)
Streptococcus mutans typically gets the blame for producing most tooth decay. (dentistrytoday.com)
Bacteria such as Streptococcus mutans are associated with tooth decay and poor teeth health. (organicfacts.net)
In the study, counts of Mutans streptococci - which promote tooth decay - were significantly reduced among those patients who used the probiotic. (orthodonticproductsonline.com)
These bacteria can also initiate the breakdown of tooth enamel, but Streptococcus mutans is the only bacteria thus far to be the most efficient and consistent in the breakdown of tooth enamel leading to tooth decay or dental caries. (uwlax.edu)
The research, published in the June issue (PDF) of the Proceedings of the National Academy of Sciences, explains how a specifically targeted antimicrobial peptide, or STAMP, known as C16G2 works to eradicate only the harmful acid-producing Streptococcus mutans bacteria, the main cause of tooth decay, without disturbing the benign and beneficial bacteria in the mouth. (wordpress.com)

For isolation of S. mutans, extracted human carious teeth were cultured in Todd-Hewit broth and Mitis-Salivarius-Bacitracin agar. (nih.gov)
Several other oral streptococci including ''S. mitis'', ''S. salivarius'' and ''S. parasanguinis'' are amylase-binding. (kenyon.edu)
Molekulare Methoden zum Nachweis des oral-probiotischen Stammes Streptococcus salivarius ssp. (ukaachen.de)
AbstractIntroduction Streptococcus salivarius is a dominant oral species and the best suitable candidate for probiotic of the oral cavity. (unesp.br)
ResumoIntrodução Streptococcus salivarius é uma espécie dominante na cavidade bucal e tem sido indicada como um ótimo candidato para uso como probiótico. (unesp.br)
Conclusão: A seleção de cepas de Streptococcus salivarius com alta atividade inibitória contra Streptococcus pyogenes, bem como aderência a células KB, pode nos levar ao próximo passo, ou seja, o uso das melhores cepas para o estudo de colonização in vivo. (unesp.br)
Some of the other species of Streptococcus that S. mutans shares its habitat with include Streptococcus salivarius, Streptococcus sangius, Streptococcus mitis, Streptococcus fecali , and Streptococcus sorbrinus . (uwlax.edu)

Lactate dehydrogenase-deficient mutants of serotype g Streptococcus mutans. (nih.gov)
Streptococcus mutans serotype E is a major bacterium causing caries, and widely present in dental plaque. (ui.ac.id)
These solutions were examined in S. mutans serotype E test cultures by the diffusion method. (ui.ac.id)
Cloning of the gene for cell-surface protein antigen A from Streptococcus sobrinus (serotype d). (semanticscholar.org)

Factors related to maternal transmission of mutans streptococci in high-risk children-pilot study. (scielo.br)

Development of anti-S. mutans virulence strategy in the proposal is also relevant to devise species-specific anti-virulence strategy targeting significant pathogens such as S. aureus and S. pneumoniae, which should open a new venue to the design of new anti-infectious agents to combat microbial infection and antibiotic resistance. (grantome.com)

Estas foram lavadas para lise das células KB e liberação das bactérias para determinação de UFC.Resultado O teste de bacteriocina, mostrou que 133 cepas apresentaram atividade inibitória contra Streptococcus pyogenes. (unesp.br)

Serotypes of Streptococcus mutans ( cricetus , rattus , ferus , sobrinus ) are primarily responsible for causing oral disease. (medscape.com)

Acidogenic activity and growth of Streptococcus mutans and of suspensions of dental plaque in the presence of glucose and sucrose]. (nih.gov)
A12 not only expressed the ADS pathway at high levels under a variety of conditions but also effectively inhibited growth and two intercellular signaling pathways of the dental caries pathogen Streptococcus mutans. (omicsdi.org)
A12 produced copious amounts of H2O2 via the pyruvate oxidase enzyme that were sufficient to arrest the growth of S. mutans. (omicsdi.org)
Determine the mechanisms of regulation of yidC1 and yidC2 in response to growth domain, and to environmental influences that are known to induce membrane stress and to affect persistence and pathogenesis by S. mutans. (grantome.com)
Finally, S. mutans utilized the reutericyclin produced by muc to impair the growth of neighboring oral commensal bacteria. (elsevier.com)
Dentifrices containing xylitol have been shown to inhibit the growth of these mutans streptococci. (ui.ac.id)
Peter Zuber, "Role of actoin dehydrogenase lipoylation in growth of Streptococcus mutans. (ohsu.edu)
Disruption of L-rhamnose biosynthesis results in severe growth defects in streptococcus mutans. (rochester.edu)
In laboratory research, scientists found that compounds found in propolis helped inhibit the growth of Streptococcus mutans, an oral bacteria known to contribute to the development of cavities. (verywellhealth.com)

Streptococcus mutans is one of the primary pathogens responsible for the development of dental caries. (omicsdi.org)
Little is known about the role of c-di-AMP signaling pathways that modulate distinct and conserved virulent properties found in S. mutans and other pathogens. (grantome.com)
However, no information is available regarding the involvement of cariogenic pathogens such as Streptococcus mutans. (elsevier.com)
The most common IE pathogens in children are gram-positive cocci, especially the α-hemolytic viridans group streptococci (e.g. (cdc.gov)

1 year of age, the viridans group streptococci are the most commonly isolated organisms. (cdc.gov)

S. mutans (ATCC 10449) and L. acidophilus (ATCC 4356). (medscimonit.com)

Results: Consumption of probiotic curd resulted in a statistically significant reduction in S. Mutans colony counts (P0.05) in both the groups. (ajol.info)
Conclusion: Short‑term consumption of probiotic curds can reduce oral S. Mutans counts. (ajol.info)

[ 42 ] reported that tooth surfaces with greater than 5% S. mutans were the most likely to become carious over a period of 10 months. (medscape.com)
[ 43 ] reported that S. mutans from carious fissures averaged 7.3% of the total cultivable count. (medscape.com)
Disk sensitivity tests and broth dilution methods were used to determine antibiotic sensitivity profile and inhibitory activity of garlic extract on S. mutans isolated from carious teeth. (nih.gov)
Of 105 carious teeth tested, 92 (87.6%) isolates of S. mutans were recovered, among which 28 (30.4%) were MDR since they were resistant to four or more antibiotics. (nih.gov)
S. mutans was first described by James Kilian Clarke (1886-1950) after he isolated it from a carious lesion, but it was not until 1960s that real interest in this microbe was generated when researchers began studying dental caries (8). (kenyon.edu)

S. mutans metabolizes sucrose to produce polysaccharides that help them cohere to one another forming plaque. (uwlax.edu)

Streptococcus mutans N66 genome sequencing project. (omicsdi.org)
A Core Genome Multilocus Sequence Typing Scheme for Streptococcus mutans. (omicsdi.org)

the inhibitory effects of these extracts on Streptococcus mutans, a major pathogen of dental caries, were investigated. (elsevier.com)

Streptococcus mutans was frequently detected in the heart valve (69%) and atheromatous plaque (74%) specimens, while other bacterial species, including those related to periodontitis, were detected with much lower frequencies. (elsevier.com)
The bacterial composition in cardiovascular tissues was found to be markedly distinct from that in dental plaque, with only a limited number of species, including S. mutans, in the cardiovascular regions shown to have possibly originated from the oral cavity. (elsevier.com)
Semiquantitative assay results revealed that S. mutans was detected in significant quantities in the heart valve (40%) and atheromatous plaque (48%) specimens, whereas the quantities of all other tested bacterial species, including several related to periodontitis, were negligible in the cardiovascular samples. (elsevier.com)

Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization. (nih.gov)

All isolates, MDR and non-MDR of S. mutans were sensitive to garlic extract with the MIC ranging from 4 to 32 microg ml(-1). (nih.gov)
Sixty-eight sequence types (STs) were identified in this cgMLST scheme (cgSTs) in 80 S. mutans isolates from 40 children that were sequenced in this study, compared to 35 STs identified by multilocus sequence typing (MLST). (omicsdi.org)
In a recent collaborative effort, we sequenced and analyzed the genomes of 57 clinical isolates of S. mutans, demonstrating that the pan-, and core-genomes contain approximately 3300 and 1400 genes, respectively. (grantome.com)
Determine how deletion of yidC1 or yidC2 affects the transcriptomes of phenotypically and genetically-diverse isolates of S. mutans using RNA-deep sequencing. (grantome.com)

1] "A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism. (tcdb.org)

To assess and compare the levels of S. mutans and C. albicans among 3-5-year-old preschool children with and without ECC and to determine the association between them. (jiaphd.org)
There was a significant difference between ECC group and non-ECC group for S. mutans ( P = 0.04) and C. albicans ( P = 0.02) levels. (jiaphd.org)
There was no significant association between S. mutans and C. albicans in ECC and non-ECC groups. (jiaphd.org)
Children with ECC were more likely to have high levels of S. mutans and C. albicans when compared to non-ECC group. (jiaphd.org)
Children with ECC presented higher levels of S. mutans and C. albicans compared to children without ECC. (jiaphd.org)
High affinity between S. mutans and C. albicans suggests interaction between these diverse species that may mediate cariogenic development. (jiaphd.org)

Salivary pH and salivary Streptococcus Mutans counts were recorded at baseline and after 30 days and statistically compared using the Student's t‑test. (ajol.info)
Salivary samples were collected and sent to the laboratory at baseline, 1 h postrinsing and after 7th day of rinsing for determining the salivary pH and S. mutans count. (fluoridealert.org)
There was a significant increase in the salivary pH and reduction in S. mutans count after rinsing in all the three groups. (fluoridealert.org)
Increase in salivary pH was more in the Sodium fluoride mouthrinse when compared to the experimental herbal groups (Group B and Group C). While S. mutans counts reduced more with Tulsi mouthrinse at 1 h postrinsing and after the 7th day of rinsing more reduction was seen in Black myrobalans mouthrinse group. (fluoridealert.org)

Furthermore, extracts of Citrus sinensis also showed inhibitory effects on S. mutans, although these effects were weaker than the effects of C. unshiu. (elsevier.com)
Conclusion: These results suggest that extracts from C. unshiu fruits exhibit inhibitory effects on S. mutans, among which albedo may be especially useful for dental caries prevention due to its neutral pH and abundant polyphenols, in addition to its inhibitory effects. (elsevier.com)

They showed statistically significant difference in efficacy against S. mutans , and poor antimicrobial effect against L. acidophilus . (medscimonit.com)
The results of the search show the antibacterial properties of natural antimicrobial peptides against Streptococcus mutans . (datadryad.org)
In addition, the antimicrobial peptides synthesized by researchers could inhibit bacteria, especially against Streptococcus mutans . (datadryad.org)

Note: Streptoccous thermophilus is a relative of Streptococcus mutans but does not cause cavities. (knowthecause.com)
She explained that the bacteria streptococcus mutans is the only bacteria that causes cavities, but xylitol is the only sweetener in which that bacteria cannot eat to create the acid which causes cavities. (domino.com)
Dental cavities are caused by bacteria - mainly Streptococcus mutans - that eat sugars or carbohydrates in the mouth. (medscape.com)

Oral streptococci depend mainly upon the phosphotransferase system (PTS) to transport carbohydrates by means of phosphorylation and translocation through the membrane. (kenyon.edu)

In the metabolism of S. mutans , it is able to cleave sucrose (after consuming carbohydrates provided by the animal diet) into glucose plus fructose. (kenyon.edu)

One of the virulence factors of S. mutans in cariogenicity is its ability to attach to the tooth surface and form a biofilm (11). (kenyon.edu)

Sequencing upstream of the Streptococcus mutans gene for a CcpA gene homolog, regM, revealed an open reading frame, named amy, with homology to genes encoding alpha-amylases. (omicsdi.org)
The proposal tests a new hypothesis that links c-di-AMP signaling to VicR-mediated expression of a variety of virulence genes through a distinct c-di-AMP receptor, and documents non-essential nature of c-di-AMP signaling in S. mutans, and explores the translational potential using anti-virulence strategy. (grantome.com)
Deletion of either yidC gene results in diminished virulence of S. mutans in a rat caries model, while deletion of both genes is lethal. (grantome.com)
A chromosomal deletion in S. mutans spanning the bglP and bglA genes resulted in a strain that was unable to hydrolyse the beta-glucoside aesculin in the presence of glucose. (tamu.edu)

Oral streptococci, including S. gordonii , rely on sugars derived mainly from carbohydrates as an energy source. (kenyon.edu)
High-carbohydrate diets undermine dental health because these foods' residue in the mouth break down into sugars, which feed the Streptococcus mutans bacteria which are also present. (chatsaudicam.com)

Following animals studies of the efficacy of liposomal S. mutans antigen vaccines, Dr. Childers has initiated human FDA Phase I clinical trials studying the safety and immunogenicity of liposomal oral and nasal immunization. (uab.edu)
Humans immunized with Streptococcus mutans antigen by mucosal routes. (uab.edu)

There are no bacteriophage genomes present in S. mutans (7). (kenyon.edu)

For example, a diet rich in dietary carbohydrate such as refined sugar favors bacteria such as Streptococcus mutans , the organism that causes dental caries. (medscape.com)

The glucose is polymerized into an extracellular dextran polymer that cements S. mutans to tooth enamel and becomes the matrix of dental plaque. (kenyon.edu)

Researchers claim that the practice helps prevent these diseases by reducing the number of Streptococcus mutans, one of the main bacteria in the mouth. (wsmagazine.net)

[ 44 ] reported S. mutans as high as 10% of the total blood agar count from molars of children with severe early childhood caries. (medscape.com)

Alexander Kendall (Pfeifer lab), "Designing Molecules for S. mutans Biofilm Inhibition. (ohsu.edu)

Anatomy6

Organisms23

Diseases7

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes32

Technology, Industry, Agriculture4

Information Science3

Health Care2

Interaction of inflammatory cells and oral microorganisms. II. Modulation of rabbit polymorphonuclear leukocyte hydrolase release by polysaccharides in response to Streptococcus mutans and Streptococcus sanguis. (1/1717)

Interaction of inflammatory cells and oral microorganisms. III. Modulation of rabbit polymorphonuclear leukocyte hydrolase release response to Actinomyces viscosus and Streptococcus mutans by immunoglobulins and complement. (2/1717)

Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model. (3/1717)

The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc. (4/1717)

Purification and properties of bacteriolytic enzymes from Bacillus licheniformis YS-1005 against Streptococcus mutans. (5/1717)

Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress. (6/1717)

Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner. (7/1717)

Humoral immunity to commensal oral bacteria in human infants: salivary secretory immunoglobulin A antibodies reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the first two years of life. (8/1717)

Streptococcus mutans

Streptococcus

Streptococcus pyogenes

Dental Caries

Streptococcus pneumoniae

Dental Plaque

Glucosyltransferases

Streptococcal Infections

Streptococcus sobrinus

Dextranase

Saliva

Streptococcus agalactiae

Mouth

Bacterial Proteins

Streptococcus mitis

Glucans

Sucrose

Streptococcus oralis

Biofilms

Diet, Cariogenic

Streptococcus suis

Streptococcus gordonii

Actinomyces

Streptococcus bovis

Bacteriocins

Bacterial Adhesion

Streptococcus sanguis

Polysaccharides, Bacterial

Streptococcus equi

Gene Expression Regulation, Bacterial

Agglutinins

Streptococcus Phages

Antigens, Bacterial

DNA Transformation Competence

DNA, Bacterial

Genes, Bacterial

Serotyping

Rhamnose

Immunoglobulin A, Secretory

Dental Pellicle

Dextrans

Cariogenic Agents

Pneumococcal Infections

Antibodies, Bacterial

Anti-Bacterial Agents

Phosphoenolpyruvate Sugar Phosphotransferase System

Streptococcus thermophilus

Molecular Sequence Data

Bacitracin

Hydroxyapatites

Culture Media

Streptococcal Vaccines

Chlorhexidine

Enterococcus faecalis

Hydrogen-Ion Concentration

Microbial Sensitivity Tests

Colony Count, Microbial

Tooth

Transformation, Bacterial

Cell Wall

Adhesiveness

Acids

Germ-Free Life

Adhesins, Bacterial

Virulence

Veillonella

Anti-Infective Agents, Local

Fructose

Sucrase

Durapatite

Amino Acid Sequence

Hexosyltransferases

Teichoic Acids

Glucose

Bacterial Load

Bacteriological Techniques

Agglutination

Antibiosis

Erythromycin

Bacteriolysis