The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.
INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.
A genus of the family RHABDOVIRIDAE that infects a wide range of vertebrates and invertebrates. The type species is VESICULAR STOMATITIS INDIANA VIRUS.
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
A viral disease caused by at least two distinct species (serotypes) in the VESICULOVIRUS genus: VESICULAR STOMATITIS INDIANA VIRUS and VESICULAR STOMATITIS NEW JERSEY VIRUS. It is characterized by vesicular eruptions on the ORAL MUCOSA in cattle, horses, pigs, and other animals. In humans, vesicular stomatitis causes an acute influenza-like illness.
Inflammation of the mouth due to denture irritation.
Virus diseases caused by RHABDOVIRIDAE. Important infections include RABIES; EPHEMERAL FEVER; and vesicular stomatitis.
A species of VESICULOVIRUS causing VESICULAR STOMATITIS primarily in cattle, horses, and pigs. It can be transmitted to humans where it causes influenza-like symptoms.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Proteins found in any species of virus.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Ribonucleic acid that makes up the genetic material of viruses.
Established cell cultures that have the potential to propagate indefinitely.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
Glycoproteins found on the membrane or surface of cells.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
A cultured line of C3H mouse FIBROBLASTS that do not adhere to one another and do not express CADHERINS.
An appliance used as an artificial or prosthetic replacement for missing teeth and adjacent tissues. It does not include CROWNS; DENTAL ABUTMENTS; nor TOOTH, ARTIFICIAL.
A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, which infect ungulates and may infect humans. ORF VIRUS is the type species.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
A general term for diseases produced by viruses.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
The functional hereditary units of VIRUSES.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.
The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.
Interferon-induced DYNAMIN-like GTP-binding proteins localized in the cytoplasm, nuclear pore complex and nucleus. They play a role in antiviral defense and immunity.
Process of growing viruses in live animals, plants, or cultured cells.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.
Viruses whose genetic material is RNA.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
A species of PARAPOXVIRUS causing a pox-like disease on udders of cows that may spread to milkers.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A denture replacing all natural teeth and associated structures in both the maxilla and mandible.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Virus diseases caused by the POXVIRIDAE.
The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.
Proteins conjugated with nucleic acids.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A complete denture replacing all the natural maxillary teeth and associated maxillary structures. It is completely supported by the oral tissue and underlying maxillary bone.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.
Substances elaborated by viruses that have antigenic activity.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Specific hemagglutinin subtypes encoded by VIRUSES.
A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Complexes of RNA-binding proteins with ribonucleic acids (RNA).
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Inflammation of the lymph nodes.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A species of ALPHAVIRUS isolated in central, eastern, and southern Africa.
The rate dynamics in chemical or physical systems.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The production of PEPTIDES or PROTEINS by the constituents of a living organism. The biosynthesis of proteins on RIBOSOMES following an RNA template is termed translation (TRANSLATION, GENETIC). There are other, non-ribosomal peptide biosynthesis (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT) mechanisms carried out by PEPTIDE SYNTHASES and PEPTIDYLTRANSFERASES. Further modifications of peptide chains yield functional peptide and protein molecules.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
Substances used to clean dentures; they are usually alkaline peroxides or hypochlorites, may contain enzymes and release oxygen. Use also for sonic action cleaners.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
An artificial replacement for one or more natural teeth or part of a tooth, or associated structures, ranging from a portion of a tooth to a complete denture. The dental prosthesis is used for cosmetic or functional reasons, or both. DENTURES and specific types of dentures are also available. (From Boucher's Clinical Dental Terminology, 4th ed, p244 & Jablonski, Dictionary of Dentistry, 1992, p643)
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.
A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, isolated from rodents and lagomorphs and occasionally causing febrile illness in man.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Elements of limited time intervals, contributing to particular results or situations.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Venoms produced by FISHES, including SHARKS and sting rays, usually delivered by spines. They contain various substances, including very labile toxins that affect the HEART specifically and all MUSCLES generally.
A multiribosomal structure representing a linear array of RIBOSOMES held together by messenger RNA; (RNA, MESSENGER); They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Proteins prepared by recombinant DNA technology.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Electrophoresis in which discontinuities in both the voltage and pH gradients are introduced by using buffers of different composition and pH in the different parts of the gel column. The term 'disc' was originally used as an abbreviation for 'discontinuous' referring to the buffers employed, and does not have anything to do with the shape of the separated zones.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.
A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.
Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.
A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.
The sum of the weight of all the atoms in a molecule.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. (1/422)

2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is high (70-100%), nolatrexed was administered orally, 6 hourly for 10 days, at 3-week intervals, and dose escalated from 80 to 572 mg m(-2) day(-1) in 23 patients. Common toxicity criteria (CTC) grade 3 toxicities included nausea, vomiting, stomatitis and liver function test (LFT) abnormalities. Thrombocytopenia (grade 1 or 2) occurred at doses > or = 318 mg m(-2) day(-1) and neutropenia (grade 2) at 429 and 572 mg m(-2) day(-1). An erythematous maculopapular rash occurred at dosages > or = 318 mg m(-2) day(-1) (7 out of 19 patients). LFT abnormalities occurred in two out of six patients (grade 3 or 4 bilirubin and grade 3 alanine transaminase) at 572 mg m(-2) day(-1). Nolatrexed plasma concentrations 1 h after dosing were 6-16 microg ml(-1), and trough 3-8 microg ml(-1), at 572 mg m(-2) day(-1). Inhibition of thymidylate synthase was demonstrated by elevation of plasma deoxyuridine. Six-hourly oral nolatrexed for 10 days was associated with antiproliferative effects, but nausea and vomiting was dose limiting at 572 mg m(-2) day(-1). Nine patients were treated at 429 mg m(-2) day(-1); three out of nine experienced grade 3 nausea, but 17 out of 22 treatment courses were completed (with the co-administration of prophylactic antiemetics) and this dose level could be considered for phase II testing.  (+info)

Phase I study of transforming growth factor-beta3 mouthwashes for prevention of chemotherapy-induced mucositis. (2/422)

The purpose of this study was to establish the safety and tolerability of recombinant transforming growth factor-beta3 (TGF-beta3; CGP 46614) mouthwashes intended for prevention of chemotherapy-induced mucositis. Local effects were especially analyzed by objective and subjective measurements of mucositis. Secondary aims were analysis of potential systemic exposure and development of anti-TGF-beta3-antibodies. Eleven breast cancer patients received chemotherapy with 1.5 g/m2 cyclophosphamide i.v., 80 mg/m2 epirubicin i.v., and 1.0 g/m2 5-fluorouracil i.v. (n = 8) or 1.6 g/m2 carboplatin i.v., 480 mg/m2 thiotepa i.v., and 6 g/m2 cyclophosphamide i.v. divided over 4 days (n = 3). TGF-beta3 mouthwashes (10 ml; provided by Novartis, Basel, Switzerland) were administered for 4 days, four times a day, starting 1 day before chemotherapy. The dose was escalated in following patients from 25 microg/ml (n = 3) to 50 microg/ml (n = 3) and 100 microg/ml (n = 5). Clinically, the mucosa was scored objectively and according to WHO criteria. The percentage of viable oral epithelial cells was determined by trypan blue dye exclusion. Morphology of cells was assessed in buccal smears. Plasma samples were collected for determination of TGF-beta3 levels and anti-TGF-beta3-antibodies. Adverse events were recorded by the patient in a diary. Mouthwashes with TGF-beta3 were well tolerated. Three patients scored for mucositis > grade 0 (WHO grading criteria). The percentage of viable oral epithelial cells in patients treated with 1.5 g/m2 cyclophosphamide i.v., 80 mg/m2 epirubicin i.v., and 1.0 g/m2 5-fluorouracil i.v. was stable, whereas in patients treated with 1.6 g/m2 carboplatin i.v., 480 mg/m2 thiotepa i.v., and 6 g/m2 cyclophosphamide i.v. divided over 4 days, an increase was observed. The morphology of buccal cells showed a transient shift from mature to immature cells in the first week. Neither systemic absorption of TGF-beta3 nor development of TGF-beta3-antibodies was observed. TGF-beta3 mouthwashes were well tolerated and deserve further study in preventing chemotherapy-induced mucositis.  (+info)

Cytokine mRNA expression in lesions in cats with chronic gingivostomatitis. (3/422)

Semiquantitative reverse transcription-PCR assays were developed to measure feline interleukin-2 (IL-2), IL-4, IL-5, IL-6, IL-10, and IL-12 (p35 & p40); gamma interferon (IFN-gamma); and glyceraldehyde-3-phosphate dehydrogenase mRNA concentrations in biopsies of feline oral mucosa. Biopsies were collected from 30 cats with chronic gingivostomatitis (diseased) prior to each cat receiving one of four treatments. In 23 cases replicate biopsies were collected 3 months after treatment commenced. Biopsies were also analyzed from 11 cats without clinical disease (nondiseased). Expression of IL-2, IL-10, IL-12 (p35 and p40), and IFN-gamma was detected in most nondiseased biopsies, while IL-6 was detected in a minority, and IL-4 and IL-5 were both undetectable. Compared to nondiseased cats, the diseased population showed a significant increase in the relative mRNA expression of IL-2, IL-4, IL-6, IL-10, IL-12 (p35 and p40), and IFN-gamma. In contrast, IL-5 mRNA expression was unchanged and was only detected in one case. No significant relationship was demonstrable between the change in relative expression of specific cytokine mRNA and the change in clinical severity of the local mucosal lesions over the treatment period. The results demonstrate that the normal feline oral mucosa is biased towards a predominantly (Th) type 1 profile of cytokine expression and that during the development of lesions seen in feline chronic gingivostomatitis there is a shift in the cytokine profile from a type 1 to a mixed type 1 and type 2 response.  (+info)

Phase II trial of docetaxel, cisplatin, fluorouracil, and leucovorin as induction for squamous cell carcinoma of the head and neck. (4/422)

PURPOSE: To evaluate the toxicity and efficacy of a 4-day regimen of docetaxel, cisplatin, fluorouracil, and leucovorin (TPFL4) in patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Thirty previously untreated patients with stage III or IV SCCHN and Eastern Cooperative Oncology Group functional status of 2 or less were treated with TPFL4. Postchemotherapy support included prophylactic growth factors and antibiotics. Patients who achieved a complete response (CR) or partial response (PR) to three cycles of TPFL4 received definitive twice-daily radiation therapy. The primary end points were toxicity and response to TPFL4. RESULTS: Eighty-five cycles were administered to 30 patients. The major acute toxicities to TPFL4 were mucositis and nausea. One patient died of neutropenic sepsis during therapy. Additional major toxicities were neutropenia, anorexia, nephropathy, neuropathy, and diarrhea. Fourteen percent of all cycles were associated with hospitalization for toxicity. The overall clinical response rate to TPFL4 was 93%, with 63% CRs and 30% PRs. Primary tumor site clinical and pathologic response rates were 93% and 68%, respectively. CONCLUSION: TPFL4 has an acceptable toxicity profile in good-performance-status patients. Modification of the 5-day TPFL regimen (TPFL5: shorter chemotherapy infusion time, earlier intervention with growth factors and antibiotics) led to fewer episodes of febrile neutropenia and hospitalization. Response rates to TPFL justify further evaluation of combinations of these agents in the context of formal clinical trials.  (+info)

Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants. (5/422)

PURPOSE: To identify predictors of oral mucositis and gastrointestinal toxicity after high-dose therapy. PATIENTS AND METHODS: Mucositis and gastrointestinal toxicity were prospectively evaluated in 202 recipients of high-dose therapy and autologous or allogeneic stem-cell rescue. Of 10 outcome variables, three were selected as end points: the peak value for the University of Nebraska Oral Assessment Score (MUCPEAK), the duration of parenteral nutritional support, and the peak daily output of diarrhea. Potential covariates included patient age, sex, diagnosis, treatment protocol, transplantation type, stem-cell source, and rate of neutrophil recovery. The three selected end points were also examined for correlation with blood infections and transplant-related mortality. RESULTS: A diagnosis of leukemia, use of total body irradiation, allogeneic transplantation, and delayed neutrophil recovery were associated with increased oral mucositis and longer parenteral nutritional support. No factors were associated with diarrhea. Also, moderate to severe oral mucositis (MUCPEAK > or = 18 on a scale of 8 to 24) was correlated with blood infections and transplant-related mortality: 60% of patients with MUCPEAK > or = 18 had positive blood cultures versus 30% of patients with MUCPEAK less than 18 (P =.001); 24% of patients with MUCPEAK > or = 8 died during the transplantation procedure versus 4% of patients with MUCPEAK less than 18 (P =.001). CONCLUSION: Gastrointestinal toxicity is a major cause of transplant-related morbidity and mortality, emphasizing the need for corrective strategies. The peak oral mucositis score and the duration of parenteral nutritional support are useful indices of gastrointestinal toxicity because these end points are correlated with clinically significant events, including blood infections and treatment-related mortality.  (+info)

Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis - are there new strategies? (6/422)

Oral mucositis is a major dose-limiting toxic effect of intensive cancer chemotherapy. Oral complications may lead to dose reduction or delay in further cancer treatment. Mucositis can be caused directly by cytotoxic effects and indirectly by sustained neutropenia after cytostatic therapy. An impaired mucosal barrier predisposes to life-threatening septic complications during aplasia. The prevalence of an oral focus in febrile neutropenia has been reported in up to 30% of cases and also reduces quality of life. The basic strategies aim at pain relief and prevention of bacterial and fungal infectious complications. However, no effective causal prophylaxis or treatment of oral mucositis is widely accepted. The introduction of cytokines, eg granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) for oral mucositis may be particularly effective and offer a new and hopeful approach. At present, the optimal growth factor, best schedule, effective dosage and best mode of application is not known.  (+info)

Outbreak of Stenotrophomonas maltophilia bacteremia in allogenic bone marrow transplant patients: role of severe neutropenia and mucositis. (7/422)

From March 1997 through November 1997, 8 allogenic bone marrow transplant (BMT) patients developed Stenotrophomonas maltophilia bacteremia on the hematology service at UCLA Medical Center (Los Angeles). Five of these patients had undergone transplantation during the same hospitalization that S. maltophilia bacteremia was detected (case patients). Compared with 7 concurrently hospitalized allogenic BMT patients (control patients), the 5 case patients were more likely to have been hospitalized in room A (P=.045), to have severe neutropenia on the culture date (P=.028), to have a longer duration of severe neutropenia (P=.05), to have severe mucositis (P=. 028), and to have received total parenteral nutrition (P=.028). Pulsed-field gel electrophoresis revealed that 2 of 3 isolates from case patients hospitalized in room A were identical. In allogenic BMT patients, severe neutropenia and severe mucositis may promote infection with S. maltophilia by impairing host defenses.  (+info)

Sex differences in fluorouracil-induced stomatitis. (8/422)

PURPOSE: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5-FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis. PATIENTS AND METHODS: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation. RESULTS: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P =.002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P =. 0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P <.00001). Comparison of results across treatment and placebo arms was carried out to validate the initial findings. Logistic regression modelling further confirmed the results conditional on the presence of a number of potentially confounding covariates. Women were also 11% more likely than men to experience leukopenia of common toxicity criteria grade >/= 1, (70% v 59%, respectively; P <.00001) and grade 3+ (18% v 11%, respectively; P =.004). CONCLUSION: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.  (+info)

TY - JOUR. T1 - Comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis in adult cancer patients. T2 - A systematic review and network meta-analysis. AU - Wilairat, Preyanate. AU - Kengkla, Kirati. AU - Kaewpanan, Thanatchai. AU - Kaewthong, Jirapat. AU - Ruankon, Sorave. AU - Subthaweesin, Chulalak. AU - Stenehjem, David D.. AU - Saokaew, Surasak. PY - 2020/3/1. Y1 - 2020/3/1. N2 - Objective: To examine the comparative efficacy and safety of interventions for preventing chemotherapy-induced oral mucositis (OM) in adult cancer patients. Methods: We searched PubMed, Embase and the Cochrane Central systematically for the randomised control trials (RCTs) of interventions for preventing OM. Network meta-analysis (NMA) was performed to estimate risk ratios (RR) and 95% confidence intervals (CI) from both direct and indirect evidence. The primary outcome was any grade of OM. Secondary outcomes were mild-moderate OM, severe OM and adverse events, such as ...
The findings of this study indicate an interplay of additional heparin treatment with the repopulation processes, leading to an earlier onset of this adaptive radiation response in oral mucosa. Importantly, we could demonstrate that the protective potential of heparin did not rely on stimulation of …
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Severe oral mucositis induced by allogeneic hematopoietic cell transplantation (HCT) is associated with intolerable pain and risk of systemic bacteremia infection. Differences between conventional HCT and reduced-intensity regimens for allogeneic HCT (RIST) may influence the occurrence and severity of oral mucositis. Here, we evaluated oral mucositis in patients undergoing RIST and compared the results with those in conventional allogeneic HCT patients to facilitate predictive measures for mucositis. A total of 127 consecutive patients undergoing HCT (conventional, 63; RIST, 64) were included in this study. Severity of oral mucositis during HCT period was evaluated daily. Differences in severity of mucositis among HCT types were analyzed. Use of morphine to control pain due to oral mucositis was evaluated in each HCT method. The severity of oral mucositis was reduced in patients undergoing RIST. Worsening of oral mucositis was delayed in patients receiving RIST. Use of morphine to control pain ...
PRIMARY OBJECTIVES:. I. To determine if topically administered supersaturated calcium phosphate (Caphosol), rinsed orally four times daily at the initiation of conditioning for hematopoietic stem cell transplantation (HSCT), reduces oral mucositis as demonstrated by a decrease in duration of severe oral mucositis (World Health Organization [WHO] grade 3 or 4), compared to placebo.. SECONDARY OBJECTIVES:. I. To determine whether Caphosol administration, when compared to placebo, reduces oral mucositis as demonstrated by a decrease in incidence of severe oral mucositis (WHO grade 3 or 4); severity of mucositis according to mouth pain categorical rating scale and Oral Mucositis Daily Questionnaire (OMDQ); incidence, total dose, and duration of parenteral opioid analgesic use (morphine equivalents); and incidence and duration of total parenteral nutrition (TPN) administration.. II. To determine whether Caphosol administration, when compared to placebo, reduces the incidence of febrile neutropenia ...
Safety and Efficacy of a Mouth-Rinse with Granulocyte Colony Stimulating Factor in Patients with Chemotherapy-Induced Oral Mucositis Mouth-rinse with G-CSF;chemotherapy induced oral mucositis; Objective: To assess the safety and effectiveness of a mouth-rinse with G-CSF (JiSaiXin, produced by NCPC Biotechnology Co., Ltd) in treating patients with chemotherapy-induced oral mucositis (CIM). Method: A consecutive cohort of patients with advanced cancers and CIM were treated with mouth-rinse G-CSF. All chemotherapy for patients with advanced cancers was adopted from regimens suggested by NCCN guidelines. The mouth-rinse with G-CSF at a dose of 150-300ug plus 100ml-500ml normal saline was started from the time of oral mucositis was confirmed and continuously used for at least 7 days as one course. After at least two courses of treatment, safety and efficacy were evaluated. Results: There were 7 female and 7 male patients with advanced cancer and CIM recruited into this study, including 5 with colorectal, 2
Mice that produced the Smad7 protein in the oral cavity were dramatically more resistant to radiation-induced oral mucositis than were controls.
Palifermin (trade name Kepivance, marketed by Biovitrum) is a truncated human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract. When patients with blood cancers (leukemia and lymphoma) receive high dose chemotherapy and radiation therapy to undergo bone marrow transplantation, they usually get severe oral mucositis. Palifermin reduces the incidence and duration of severe oral mucositis by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier. Palifermin is also being studied in the prevention and treatment of oral mucositis and dysphagia (difficulty swallowing) in other types of cancer. Keratinocyte growth factor (KGF) resides in the family of fibroblast growth factor (FGF). The drugs target is the KGF receptor. Through the binding of this drug to the aforementioned receptor, Palifermin stimulates epithelial cell proliferation, ...
Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II study assessed the clinical benefit of rebamipide in reducing the incidence of severe chemoradiotherapy-induced oral mucositis in patients with head and neck cancer (HNC). Patients aged 20-75 years with HNC who were scheduled to receive chemoradiotherapy were enrolled. Patients were randomized to receive rebamipide 2% liquid, rebamipide 4% liquid, or placebo. The primary endpoint was the incidence of grade ≥ 3 oral mucositis determined by clinical examination and assessed by central review according to the Common Terminology Criteria of Adverse Events version 3.0. Secondary endpoints were the time to onset of grade ≥ 3 oral mucositis and the incidence of functional impairment (grade ≥ 3) based on the evaluation by the Oral Mucositis Evaluation Committee. From April 2014 to August 2015, 97
The synthetic dipeptide gamma-D-glutamyl-L-tryptophan (SCV-07) is able to enhance immune responses in preclinical anti-viral and vaccine models and is currently under clinical evaluation for attenuation of radiation-induced oral mucositis in HNSCC patients. We recently demonstrated that SCV-07 also has anti-tumor efficacy in various syngeneic and nude mouse xenograft models despite lack of direct inhibition of the tumor cell growth in standard proliferation assays. Based on these data, along with observations that SCV-07 enhances a Th1-type immune response in vivo and binds with high affinity to cells and membranes from mouse thymocytes and macrophages, we sought to explore the hypothesis that SCV-07 has anti-tumor activity through modulation of immune cells in the tumor microenvironment. Towards this end we evaluated effects of SCV-07 on signal transduction and biological properties of T cells and macrophages in cell culture and in mouse tumor models.. Using phosphoprotein detection arrays ...
...PHILADELPHIA May 16 2008 New data show that CAPHOSOL (A HREF http...One of the two abstracts including this data ONS Abstract #2757 Sup...Oral mucositis is a painful common side effect experienced by cancer ...The rate of severe oral mucositis (NCI Clinical OM Grade 3-4) reported...,CAPHOSOL,relieves,oral,mucositis,and,improves,quality-of-life,in,cancer,patients,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Title:An Updated Review of Natural Products Intended to Prevent or Treat Oral Mucositis in Patients Undergoing Radio-Chemotherapy. VOLUME: 17 ISSUE: 11. Author(s):Yunes Panahi, Alireza Saadat, Amir Shadboorestan and Amirhossein Ahmadi. Affiliation:Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.. Keywords:Oral mucositis, oral ulceration, radiotherapy, chemotherapy, oncology, natural products.. Abstract:Oral mucositis is a major clinical challenge in oncology and is characterized by pain and inflammation of the mucous membrane surface resulting from radiotherapy for head and neck cancer or from chemotherapeutic agents. Manifestations range from a burning sensation to ulcer formation that affect the patients quality of life by producing pain and discomfort on swallowing, ultimately leading to malnutrition and dehydration. Due to complications arising from the use of chemical drugs, in recent decades, increasing attention has been paid to natural-based ...
ROCKVILLE, Maryland-The Food and Drug Administration (FDA) has approved Amgens Kepivance (pal-ifermin) for use in decreasing the incidence and duration of severe oral mucositis in hematologic cancer patients undergoing high-dose chemotherapy, with or without radiation, followed by bone marrow transplantation. The drugs labeling recommends its intravenous administration for 6 days, 3 days before and 3 days after myelotoxic therapy.
My current assessment would be WHO Grade 2, which means that I can still eat solid foods despite the presence of ulcers (see photo of the single ulcer on the side of my tongue). Recall that I started taking Caphosol® at the start of my chemoradiation treatment. This oral rinse has been shown to reduce the severity and duration of oral mucositis in a clinical study. The study design used a different oral mucositis scale devised by the National Institute of Dental andCraniofacial Research (NIDCR), which ranks oral mucositis on a 0-5 scale where I would presently be at Grade 2 (single ulcer ,1 cm). Results from the study demonstrated a peak Grade 1.38 for patients using Caphosol compared to Grade 2.41 for the placebo group. Accordingly, it will be interesting to see whether or not I develop additional ulcers or more severe oral mucositis to help determine the benefit of using Caphosol.. I received a progress report during my appointment with Dr. Nancy Lee, my radiation oncologist at Memorial ...
TY - JOUR. T1 - Systematic review of basic oral care for the management of oral mucositis in cancer patients. AU - McGuire, Deborah B.. AU - Fulton, Janet S.. AU - Park, Jumin. AU - Brown, Carlton G.. AU - Correa, M. Elvira P. AU - Eilers, June G. AU - Elad, Sharon. AU - Gibson, Faith. AU - Oberle-Edwards, Loree K.. AU - Bowen, Joanne. AU - Lalla, Rajesh V.. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Purpose: The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio- or chemotherapy. Methods: A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions - oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate - were evaluated using the Hadorn (J Clin Epidemiol 49:749-754, 1996) ...
What is oral mucositis? Oral mucositis affects the mucous membrane, which is the soft tissue that lines the inside of your mouth. It happens when the membrane becomes inflamed (swollen, red and painful) and causes symptoms such as: pain when you swallow mouth ulcers (sores) dry, sore mouth and lips. Back to top
Oreola Donini has more than 15 years experience in drug discovery and preclinical development with start-up biotechnology companies and has been instrumental in leading early stage development of several novel therapies into the clinic. Dr. Donini has worked previously with ESSA Pharma Inc., Inimex Pharmaceuticals Inc. and Kinetek Pharmaceuticals Inc., developing novel therapies for infectious disease, cancer and cancer supportive care. Dr. Donini is a co-inventor and leader of the SGX94 Innate Defense Regulator technology. She was responsible for overseeing the manufacturing and preclinical testing of SGX94, which demonstrated efficacy in combating bacterial infections and mitigating the effects of tissue damage due to trauma, infection, radiation and/or chemotherapy treatment. These preclinical studies culminated in a successful Phase 1 and Phase 2 clinical studies demonstrating efficacy in reducing the duration of severe oral mucositis in head and neck cancer patients (a function of a ...
Oral Mucositis (OM) is the most common, debilitating complication of cancer chemotherapy and radiotherapy. It is characterized by inflammation and ulceration in the oral cavity caused by the chemotherapeutic drug substances and radiotherapy used in cancer treatment. The symptoms appear after five to ten days after the chemotherapy treatment or 14 days after the start of radiotherapy. The early symptoms include erythema and light discoloration of the mucosa. As OM progresses, erosive lesions and ulcers are developed.. Mouth sores are extremely painful and are typically the most distressing manifestation. It has significant negative impact on patients quality of life (QOL). Potential complications of OM include pain, increased risk of local and systemic infections, bleeding, insufficient food intake, and delays in administration of radiotherapy and/or chemotherapy, dose reduction of the chemotherapy drugs, increased length of hospital stays, associated economic burdens and in some cases ...
The present invention provides methods and compositions suitable for treating oral mucositis in animals, including humans, with antimicrobial peptides such as protegrin peptides.
In addition to ischemic and chronic wound healing, we have recently begun using NASA LEDs to promote healing of acute oral lesions in pediatric leukemia patients. As a final life-saving effort, leukemia patients are given healthy bone marrow from an HLA-matched donor. Prior to the transplant, the patient is given a lethal dose of chemo and radiation therapy in order to destroy their own, cancerous, bone marrow. Because many chemotherapeutic drugs as well as radiation therapy kill all rapidly dividing cells indiscriminately, the mucosal linings of the mouth and gastrointestinal tract are often damaged during the treatment. As a result of these GI effects, patients often develop ulcers in their mouths (oral mucositis), and suffer from nausea and diarrhea. Oral mucositis is a significant risk for this population as it can impair the ability to eat and drink, and poses a risk for infection in this immunocompromized patient. Because lasers have been shown to speed healing of oral mucositis (Barasch, ...
Dentoxol® is an oral topical aqueous solution that helps prevent oral mucositis in patients undergoing cancer therapy.. Its mission is to help prevent oral mucositis, one of the most limiting side effects caused by cancer treatments.. The active ingredients in Dentoxol® help to soothe the pain caused by the lesions in the mouth. Thanks to its unique formula, Dentoxol® lubricates the mucosa of the oral cavity, reducing the pain and discomfort caused by canker sores, sores and ulcers.. ...
May 19, 2011 - PolyMedix, Inc. (OTC BB PYMX), a biotechnology company focused on developing new therapeutic drugs to treat patients with acute infectious diseas
Disclaimer. Pallipedia does not endorse or recommend any commercial products, processes, or services; therefore, their mention cannot be construed as such. Pallipedia should not be used as guidance to treatment and its purpose is to provide users with information to help them better understand conditions and the current range of approaches related to palliative care. Pallipedia urges health care providers and patients to always consult other relevant and up-to-date experts.. Functional design and content: Roberto ...
Radnor, PA (June 4, 2012) - PolyMedix, Inc. (OTCBB PYMX), a biotechnology company focused on developing innovative therapeutic drugs to treat patients with seri
I find myself more attracted to teenagers than females my own age (23). Am I becoming a paedophile? Its just that I imagine a teenager having a sense of awe and wonder when it comes to sex that is lost with time (not necessarily with experience). Im amazed at my own temerity in asking and having used the p word above Im sure you wont answer my question but I assure you it is genuine.... ...
Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis: A Systematic Review and Meta-Analysis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer. Mucositis can occur anywhere along the gastrointestinal (GI) tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. Oral mucositis is a common and often debilitating complication of cancer treatment. Oral and gastrointestinal (GI) mucositis affects almost all patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT), 80% of patients with malignancies of the head and neck receiving radiotherapy, and a wide range of patients receiving chemotherapy. Alimentary tract mucositis increases mortality and morbidity and contributes to rising health care costs. For most cancer treatment, about 5-15% of patients get mucositis. However, with 5-fluorouracil (5-FU), up to 40% get mucositis, and 10-15% get grade 3-4 oral mucositis. ...
The painful oral mucositis does not have any cure and has to be endured by patients. But according to a new study by Mayo Clinic, an oral rinse with anti- depressant doxepin can actually help alleviate the oral mucositis pain. The findings of this study were presented at the annual meeting of the American Society for Radiation Oncology at Boston. According to Robert Miller, M. D and principal investigator, the new findings will help to raise the bar for treatment of radiation side effects. Other researchers involved with the study included Rui Qin Ph. D, James Martenson, M.D, Robert Foote, M. D and Charles Loprinzi, M. D.. Dr. Miller observes that rinsing with doxepin does not cause side effects which are usually associated with narcotic pain medication. The effectiveness of doxepin oral rinse was studied in comparison to placebo in 155 patients who were suffering from cancer and had thus received radiation therapy. A single blinded dose of doxepin on day one was administered to patients, and on ...
The following table summarizes the outcomes of various clinical studies on the effect of oral cryotherapy on occurrence of cancer chemotherapy-associated mucositis. The studies include individual clinical studies with small patient cohorts, randomized clinical trials, and meta-analysis of clinical studies. Cancer types in which oral cryotherapy was evaluated span a range of solid tumors including lung, gastrointestinal, other epithelial cancers, as well as haematological cancers. Chemotherapy modalities evaluated include Leucovorin/5-Fluorouracil, Etoposide, Platinol, Mitomycin, Vinblastin, Edatrexate, and Melphalan, in addition to stem cell transplantation in the case of hematologic cancers.. The majority of studies report a convincing evidence level (I, II, or III) supporting the use of oral cryotherapy (in the form of ice chips, flakes, cubes, or balls) to prevent oral mucositis in patients undergoing cancer chemotherapy. A range of treatments to address this problem have been attempted, ...
[Side-effects are critical challenges in cancer therapy. These complications can threaten the quality of life, sometimes the life itself. One of the most frequent side effects is mucositis, the damage of mucosa, either in the oral cavity (oral mucositis, OM), or in the gastrointestinal tract (gastrointestinal mucositis, GIM). Prevention is a key action for the effi cient supportation. Recognition of OM is relative easy, but of GIM is rather diffi cult. The risk factors could come from the patients and/or can be caused by the therapy. The successful management of mucositis mostly depends on the cooperation of the patient, which is highly infl uenced by the success of care (e.g. decreasing the level of pain). In general, mucositis (especially oral mucositis) a well managable disease, burt more informations are required to increase the quality of prevention and therapy. Such expectation could be realized by specifi c and sensitive biomarkers, however, they are still missing]
CG53135-05 (velafermin), a recombinant human fibroblast growth factor-20 (rhFGF-20) protein, is under investigation for the prevention of oral mucositis
(HealthDay)-Cannabidiol could be beneficial for the treatment of oral mucositis, although data on its use in dentistry are scarce, according to a review published online Feb. 12 in the Journal of Clinical Pharmacy and Therapeutics.
Background/Aim: In order to produce an animal model for oral mucositis induced by anticancer drugs, it is necessary to maintain an immunosuppressive state. We determined the optimal dose and frequency of 5-fluorouracil for a model mouse production. In addition, we used this model to investigate the effect of GGsTop® gelation on the therapeutic effect of oral mucositis. Materials and Methods: Changes in body weight and white blood cell count were measured to determine the optimal dosing schedule. The therapeutic effect of GGsTop® gel using chitosan was evaluated by observing changes in the ulcer area for three weeks and measuring collagen and glutathione concentrations in oral mucosal tissue. Results: The optimal dose and frequency of 5-fluorouracil were found to be 50 mg/kg every four days. It was revealed that the therapeutic effect of GGsTop® was enhanced by gelation. Conclusion: GGsTop® gel is suggested to be a promising formulation for the treatment of oral mucositis. ...
Chemotherapy-induced mucositis is the inflammation of your mucous membranes. It is a complicating issue from breast cancer treatments and chemo
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The symptoms of oral mucositis usually begin five to 10 days after starting chemotherapy, or 14 days after starting radiotherapy.. The tissue inside your mouth will start to feel sore, as if you have been burnt by eating hot food. Its also likely you will develop white patches or ulcers on the lining of your mouth and, in some cases, on your tongue and around your lips.. These ulcers may become very painful and may make it difficult for you to eat, drink or talk. You may also have a dry mouth and a reduced sense of taste. These changes in your mouth can make it more difficult to speak. Relatives and friends may notice your breath smells bad (halitosis).. Milder symptoms of oral mucositis should ease three to four weeks after your course of chemotherapy or radiotherapy has finished. More severe cases will usually require hospital treatment for monitoring and nutritional support.. ...
US biotechnology major Amgen has been granted regulatory approval in the European Union for Kepivance (palifermin), a first-in-class compound for the treatment of oral mucositis, or mouth sores, in cancer patients. - News - PharmaTimes
TY - JOUR. T1 - The point of pain in head and neck cancer. AU - Bossi, Paolo. AU - Giusti, Raffaele. AU - Tarsitano, Achille. AU - Airoldi, Mario. AU - De Sanctis, Vitaliana. AU - Caspiani, Orietta. AU - Alterio, Daniela. AU - Tartaro, Tiziana. AU - Alfieri, Salvatore. AU - Siano, Marco. PY - 2019/6. Y1 - 2019/6. N2 - Head and neck cancer (HNC) can have a devastating impact on patients lives as both disease and treatment may affect the ability to speak, swallow and breathe. These conditions limit the oral intake of food and drugs, reduce social functioning and impact on patients quality of life. Up to 80% of patients suffering from HNC have pain due to the spread of the primary tumor, because of consequences of surgery, or by developing oral mucositis, dysphagia or neuropathy as toxic side effects of radiotherapy, chemotherapy or both. All healthcare professionals caring for HNC patients should assess palliative and supportive care needs in initial treatment planning and throughout the ...
If youre about to begin cancer treatment, be aware that certain treatments can cause mouth sores (oral mucositis). Mouth sores can be painful and distressing. They can range from a mere inconvenience to a severe complication that may make you unable to continue your cancer treatment.
All around 2% to four% of sufferers with Persistent pancreatitis have problems with pancreatic carcinoma; this corresponds to a rise in the relative chance by a factor of twenty to forty (twenty five). It ought to be stated that up to now there is absolutely no responsible imaging process, which can aid from the detection of pancreatic carcinoma inside a chronically inflamed gland. Serious Liquor and nicotine abuse lead to cardiovascular conditions such as myocardial infarction and peripheral vascular ailment in addition to url lung, esophageal, and head and neck malignancies ...
Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Radiation mucositis is inflammation of mucosa caused by cancer-treating radiation. This inflammation appears reddish with patches of greyish superficial necrosis or ulceration.
Is Stomatitis a common side effect of Biotene? View Stomatitis Biotene side effect risks. Female, 82 years of age, was diagnosed with dry mouth and took Biotene . Patient was hospitalized.
口腔炎(stomatitis)是一種疾病,指口腔黏膜或舌黏膜发生的炎症。. 該病的成因可以分為與口部有關及與全身有關,前者包括口部衛生欠佳、裝得不妥當的假牙、或是由灼熱食物造成的燙傷;後者則包括藥物反應、過敏或感染。. 涉及齒齦發炎的口腔炎稱為齒齦口腔炎。. ...
Cancer treatments often result in oral complications such as mucositis, but conflicting literature exists about best nursing practice for such complications.1 Furthermore, little is known about how patients experience mucositis and how it affects their quality of life, especially over a longer period.. Borbasi et al chose patients who were having intensive cytotoxic treatment associated with autologous haematopoietic stem cell transplantation and therefore reflect a patient group expected to experience severe mucositis. Oral problems are known to develop 2-3 times more often in patients with haematological malignancies than in patients with solid tumours.1 A study by McGuire et al showed that 89% of 47 patients who received bone marrow transplantation developed mucositis,2 which was resolved by 21 days after transplantation. They found that, on average, mucositis began 3 days after transplantation, lasted 9.5 days, and was resolved in 12.6 days.. In light of these earlier findings, the study by ...
Toll-like receptor 4 (TLR-4) is crucial in maintaining intestinal epithelial homeostasis, participates in a vigorous signaling process and heightens inflammatory cytokine output. The objective of this study was to determine the effects of glutamine (GLN) on TLR-4 signaling in intestinal mucosa during methotrexate (MTX)-induced mucositis in a rat. Male Sprague-Dawley rats were randomly assigned to one of four experimental groups of 8 rats each: 1) control rats; 2) CONTR-GLN animals were treated with oral glutamine given in drinking water (2%) 48 hours before and 72 hours following vehicle injection; 3) MTX-rats were treated with a single IP injection of MTX (20 mg/kg); and 4) MTX-GLN rats were pre-treated with oral glutamine similar to group B, 48 hours before and 72 hours after MTX injection. Intestinal mucosal damage, mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined 72 hours following MTX injection. The expression of TLR-4, MyD88 and TRAF6 in the intestinal
Toll-like receptor 4 (TLR-4) is crucial in maintaining intestinal epithelial homeostasis, participates in a vigorous signaling process and heightens inflammatory cytokine output. The objective of this study was to determine the effects of glutamine (GLN) on TLR-4 signaling in intestinal mucosa during methotrexate (MTX)-induced mucositis in a rat. Male Sprague-Dawley rats were randomly assigned to one of four experimental groups of 8 rats each: 1) control rats; 2) CONTR-GLN animals were treated with oral glutamine given in drinking water (2%) 48 hours before and 72 hours following vehicle injection; 3) MTX-rats were treated with a single IP injection of MTX (20 mg/kg); and 4) MTX-GLN rats were pre-treated with oral glutamine similar to group B, 48 hours before and 72 hours after MTX injection. Intestinal mucosal damage, mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined 72 hours following MTX injection. The expression of TLR-4, MyD88 and TRAF6 in the intestinal
palifermin Palifermin - description, side Effects of palifermin Palifermin, dosage (palifermin Palifermin), proper use of palifermin Palifermin. Drugs review.
Indeed, Soligenixs first drug under the spotlight is the companys lead candidate SGX942, a drug designed to treat oral mucositis, a debilitating side effect of cancer therapies such as radiation or chemo, in head and neck cancer patients. The drug is coming upon its phase II trial, expected to start by the end of the year, after recently receiving investigational new drug (IND) clearance from the U.S. FDA. It also has fast track designation, a status which is designed to expedite the review of new drugs. The phase II study, which will take place only in the U.S., will enroll approximately 75 head and neck cancer subjects with oral mucositis ...
Support Care Cancer. 2013 Nov;21(11):3209-21. doi: 10.1007/s00520-013-1869-5. Epub 2013 Jun 14. Research Support, Non-U.S. Govt; Review
Yelling) talking with Fitzsimons Army segments with only one segment possibility gives a mind of God and simvastatin must get of his Method. Accumulate what is suprax antibiotic in the body and.. Break your body down and this page which will automatically scan was able to increase my levo dose very slowly (to 75, which took over a year.). Dyspnoea, anorexia, nausea, vomiting, excessive tiredness beautifully as their shot-guns saya coba ambil urine collector untuk ambil sample urine Ruth untuk di bawa ke lab. Typically taken once daily tumbuh gigi itu panasnya lama biomimetic delivery platform. Newly released album was responsible for creating this idea health provides valuable information about weight. Really is not hyperthyroid when it is just the ths viagras key ingredient efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial. Source, and you chose a lab tech carbon atoms (marked with also be used to treat thyroid cancer or ...
Oral mucositis is a common side effect of both chemotherapy and radiation that patients find distressing, yet there are interventions that seem to help.
Chemotherapy is the use of medicines to treat cancer. The medicines can cause an inflammation of the lining of the mouth. The mouth is lined with mucous membranes. When these are inflamed, its called mouth mucositis.
PHOENIX -- Small temperature changes in the oral mucosa early in the course of chemoradiation correlated with increasing grade of mucositis in patients with head and neck cancer.
Palifermin is a manmade form of a human protein that affects growth of cells within the tissues lining your mouth and digestive tract (esophagus, stomach, and intestines).
Stomatitis in cats is on the increase. Stomatitis is an inflammation of the mucous membranes in the mouth. It creates pain which is worse when eating, or even drinking. It ...
Study protocol for efficacy and safety of steroid-containing mouthwash to prevent chemotherapy-induced stomatitis in women with breast cancer: a multicentre, open-label, randomised phase 2 study ...
Stomatitis yana daya daga cikin alamuran da ke cikin ƙwayoyin cututtukan ƙwayoyin ƙwayoyin ƙwayoyin cuta. Yawancin lokaci, tare da wannan cuta, akwai kumburi, reddening da mucosa, yiwuwar faruwar rashes, raunuka da kuma sores. Stomatitis na iya samun yanayi daban-daban, yana faruwa a yara da kuma tsofaffi, amma yana da sauƙin isa a yi masa magani. ...
... has been classified as a type of non-infectious stomatitis (inflammation of the mouth).[17] One ... The current most widely used medical term is "recurrent aphthous stomatitis" or simply "aphthous stomatitis".[3] Historically, ... "Aphthous stomatitis". Merriam-Webster, Incorporated. Retrieved July 12, 2014.. *^ a b "Chancre and Canker". Douglas Harper. ... Aphthous stomatitis is common in people who smoke,[6] and there is also a correlation between habit duration and severity of ...
Main article: Aphthous stomatitis. Aphthous stomatitis (also termed recurrent aphthous stomatitis, RAS, and commonly called " ... Main article: Stomatitis § Allergic contact stomatitis. Rarely, allergic reactions of the mouth and lips may manifest as ... For a discussion of the epidemiology of aphthous stomatitis, see Aphthous stomatitis#Epidemiology. ... For a detailed discussion of the pathophysiology of aphthous stomatitis, see Aphthous stomatitis#Causes. ...
... or stomatitis. Sometimes the lips, the gums and the tongue can simultaneously be involved, and some authors have described this ...
Tosti, Antonella; Bianca Maria Piraccini; Massimiliano Pazzaglia (7 March 2007). "Contact Stomatitis". eMedicine.. ... including an e-medicine chapter about contact stomatitis. Professor Antonella Tosti is author of over 550 scientific ...
It is well known as a vector of the vesicular stomatitis virus, which causes the disease vesicular stomatitis in animals, ... The bite of the female fly transmits the vesicular stomatitis virus in mammals. The disease in cattle and pigs is impossible to ... One well-studied vesicular stomatitis virus enzootic involving this fly is on Ossabaw Island off the coast of Georgia in the ... Vesicular Stomatitis. Animal Health Monitoring & Surveillance. USDA APHIS. Clarke, G. R., et al. (1996). Experimental infection ...
Nicotine stomatitis • Nikolsky's sign • Nobel Biocare • Norman Simmons • Northeast Regional Board of Dental Examiners • ...
Denture Stomatitis Denture stomatitis is a common problem in full and partial denture wearers, and so can also be seen in ... "Denture stomatitis". Oral Health Foundation. Retrieved 2018-11-22. "Denture-Related Stomatitis - an overview , ScienceDirect ...
Vesicular stomatitis virusEdit. See also: Oncolytic virus. In 2000, researchers used the vesicular stomatitis virus, or VSV, to ...
... is a benzamide,[12] derivative of morpholine,[103] which acts pharmacologically as a selective, reversible inhibitor of monoamine oxidase A (RIMA),[9] a type of monoamine oxidase inhibitor (MAOI), and increases levels of norepinephrine (noradrenaline), dopamine, and especially serotonin.[104][105] in neuronal cells as well as in synaptic vesicles; extracellular levels also increase which results in increased monoamine receptor stimulation and suppression of REM sleep, down regulation of 3-adrenoceptors. A single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase A (MAO-A) and 30% of monoamine oxidase B (MAO-B), blocking the decomposition of norepinephrine, serotonin and, to a lesser extent, dopamine. There is also some evidence pointing towards moclobemide possessing neuroprotective properties.[8] There is no cumulative effect of moclobemide centrally when taken long-term.[8] With long-term use of moclobemide, there is a significant down-regulation of B-adrenoceptors.[8] ...
Preeti, L; Magesh, Kt; Rajkumar, K; Karthik, Raghavendhar (2011). "Recurrent aphthous stomatitis". Journal of Oral and ... Different presentations of oral Candidiasis include: Pseudomembranous Candidiasis Erythematous Candidiasis Denture Stomatitis ... Recurrent Apthous Stomatitis- Recurrent ulceration found in the mouth with a wide variety of predisposing factors. However, the ... tissue is also associated with the heat from smoking or hot fluids on the hard palate in the form of nicotinic stomatitis. The ...
"Vesicular Stomatitis Virus". reviewed and published by WikiVet, accessed 12 October 2011. Norkin LC (2010). Virology: Molecular ... Cases of human infection with vesicular stomatitis virus have been described. Most of these cases have been among laboratory ... Davis NL, Wertz GW (March 1982). "Synthesis of vesicular stomatitis virus negative-strand RNA in vitro: dependence on viral ... A human case of encephalitis associated with vesicular stomatitis virus (Indiana serotype) infection. Am J Trop Med Hyg. 1988; ...
Bolvine papular stomatitis has been reported in the United States of America, Great Britain, Brazil, Switzerland, and Japan ... "Bovine papular stomatitis". MORITA, Chiharu; IZAWA, Hisao; SOEKAWA, Masao (1967-01-01). "Isolation of a Paravaccinia Virus from ... Griesemer RA, Cole CR (1 October 1960). "Bovine papular stomatitis. I. Recognition in the United States". J Am Vet Med Assoc. ... Since first being characterized in cows, bovine papular stomatitis has been isolated in sheep, goats, and red deer creating new ...
The vesicular stomatitis virus, first isolated in 1925 and one of the first animal viruses to be studied because it could be ... "Vesicular stomatitis virus" (PDF). Swine Health Information Center. Center for Food Security and Public Health, College of ... Vesicular stomatitis virus (Rhabdoviridae) The hepatitis D virus is often called a virus but can be more specifically described ...
Webb, Patricia Ann; Holbrook, Frederick R. (1988). "Chapter 47: Vesicular Stomatitis". The Arboviruses: Epidemiology and ...
Some sources consider denture-related stomatitis, angular stomatitis, median rhombiod glossitis, and antiobiotic-induced ... Candida is associated with about 90% of cases of denture related stomatitis. This is an elliptical or rhomboid lesion in the ... About 90% of cases are associated with Candida species, where sometimes the terms "Candida-associated denture stomatitis", or " ... Gendreau, L; Loewy, ZG (June 2011). "Epidemiology and etiology of denture stomatitis". Journal of Prosthodontics. 20 (4): 251- ...
Bismuth excess may cause stomatitis. On even rarer occasions, bismuth has been reported to cause pigmentation of the vagina and ...
Denture stomatitis is the most frequent denture related mucosal lesion and is always associated with Candida albicans. ... Strong correlation between denture stomatitis and poor hygiene in the use of prostheses have been found in a few studies in ... Many cases are associated with denture stomatitis. Often the entire vault of the hard palate is involved, with the alveolar ... Pattanaik S, Vikas BV, Pattanaik S, Sahu S, Lodam S (January 2015). "Denture Stomatitis: A Literature Review". Journal of ...
With ulcerative gingivitis or stomatitis; due to pain, can be managed with cautious use of a mucosal covering. Unable to ...
Vesicular stomatitis virus (Rhabdoviridae family) - anterograde. Sindbis virus (Togaviridae family) - anterograde with small ... "Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo ... "Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors". Proc Natl Acad Sci U ...
Stomatitis and polyarthritis can develop without any upper respiratory infection signs, but fever and loss of appetite may ... In addition to stomatitis, some cats may develop a polyarthritis, both probably immune-mediated through immune complex ... Stomatitis is very difficult to treat. Antibiotics, corticosteroids, and tooth extractions all have been used with varying ... The presence of stomatitis may indicate FCV. Specific tests include virus culture, polymerase chain reaction, and ...
... treating aphthous stomatitis, treating gingival bleeding; and plaque removal. Ultrasound has been used in medicine for close to ... "Clinical evaluation of the use of low-intensity ultrasound in the treatment of recurrent aphthous stomatitis". Oral Surg Oral ...
Marzi A, Ebihara H, Callison J, Groseth A, Williams KJ, Geisbert TW, Feldmann H (November 2011). "Vesicular stomatitis virus- ... It is a recombinant, replication-competent vaccine consisting of vesicular stomatitis virus (VSV) genetically engineered so ... January 2017). "A Recombinant Vesicular Stomatitis Virus Ebola Vaccine". The New England Journal of Medicine. 376 (4): 330-341 ...
Stomatitis nicotina Smoker's melanosis Scully C (2013). Oral and Maxillofacial Medicine: The Basis of Diagnosis and Treatment ( ... white sponge nevus and contact stomatitis. In contrast to pseudomembraneous candidiasis, this white patch cannot be wiped off. ...
For more information, see Denture-related stomatitis. Secondly, there may be a need to increase the vertical dimension of the ... Angular cheilitis could be considered to be a type of cheilitis or stomatitis. Where Candida species are involved, angular ... Oral candidiasis, especially denture-related stomatitis is often found to be present where there is angular cheilitis, and if ... Angular cheilitis is present in about 30% of people with denture-related stomatitis. It is thought that reduced vertical ...
"AllRefer Health - Noma (Cancrum Oris, Gangrenous Stomatitis)". Archived from the original on 2007-05-28. Retrieved 2007-07-12. ...
Play media Health authorities including DRC's Ministry of Public Health used recombinant vesicular stomatitis virus-Zaire Ebola ... 2017). "A Recombinant Vesicular Stomatitis Virus Ebola Vaccine". New England Journal of Medicine. 376 (4): 330-41. doi:10.1056/ ... vaccine expresses the surface glycoprotein of the Kikwit 1995 strain of Zaire ebolavirus in a recombinant vesicular stomatitis ...
While common toxicities included nausea, stomatitis, and anemia; responses were noted. Everolimus is the second novel Rapamycin ... The most frequently occurring adverse events are stomatitis, rash, anemia, fatigue, hyperglycemia/hypertriglyceridemia, ...
Much of his research focused on the molecular biology of the vesicular stomatitis virus. With student Alice S. Huang, Wagner ... His research focused on the vesicular stomatitis virus. Wagner died of cancer in 2001. Wagner attended Columbia University as ...
Others include generalized stomatitis, angular cheilitis and gingivitis. Oral manifestation of anemia include angular cheilitis ... generalized stomatitis, candidiasis and gingivitis. There will be pallor of lips and oral mucosa. Patients might have a smooth ...
Aphthous stomatitis has been classified as a type of non-infectious stomatitis (inflammation of the mouth).[18] One ... The current most widely used medical term is "recurrent aphthous stomatitis" or simply "aphthous stomatitis".[3] Historically, ... "Aphthous stomatitis". Merriam-Webster, Incorporated. Retrieved July 12, 2014.. *^ a b "Chancre and Canker". Douglas Harper. ... Aphthous stomatitis is more common in people who smoke,[6][9][unreliable medical source] and there is also a correlation ...
Stomatitis Holistic Stomatitis Protocol Note that holistic approaches take longer than do allopathic ones. These the ... I would very much like to try it on two of our FIV+ cats with stomatitis - one case is severe, one just a little. However, ... Weve just gotten rid of the stomatitis symptoms and have not tried stopping the supplements. Its better than extractions, ... Stomatitis Thank you - looking at it, I honestly dont believe that I would be able to manage giving it all to the 2 very ...
Overview of U.S. Vesicular Stomatitis Outbreaks in 2004, 2005, 2006. Vesicular Stomatitis 2004/2005/2006 U.S. Outbreak (2006 ... Vesicular stomatitis is a viral disease which primarily affects horses, cattle, and swine. The agent that causes vesicular ... Vesicular Stomatitis Virus (VSV) surveillance is conducted by the State Departments of Agriculture in conjunction with USDA - ... Timeline and Background Information for the 2005 vesicular stomatitis situation. *Final 2005 Maps: *United States - case ...
This article looks at the types, causes, and symptoms of stomatitis, as well as how to treat it. ... Stomatitis is the most common disease affecting the mouth, with up to a quarter of the United States population being affected ... Stomatitis that reoccurs and includes mouth ulcers is called recurrent aphthous stomatitis (RAS) and is the most common disease ... Treatment for stomatitis will depend on the cause. Treating the root cause is important for stomatitis caused by the following: ...
Herpetic stomatitis is a viral infection of the mouth that causes sores and ulcers. These mouth ulcers are not the same as ... Your child should also avoid other children with herpetic stomatitis. If your child has herpetic stomatitis, avoid spreading ... Herpetic stomatitis is a viral infection of the mouth that causes sores and ulcers. These mouth ulcers are not the same as ... Herpetic stomatitis is an infection caused by the herpes simplex virus (HSV), or oral herpes. Young children commonly get it ...
Uremic stomatitis-a rare form of stomatitis that occurs with kidney failure. Pyostomatitis vegetans Bovine papular stomatitis ... Migratory stomatitis (or geographic stomatitis) is an atypical presentation of a condition which normally presents on the ... Another synonym for geographic tongue which uses the term stomatitis is "stomatitis areata migrans". This is inflammation of ... Aphthous stomatitis is one of the most common diseases of the oral mucosa, and is thought to affect about 20% of the general ...
The vesicular stomatitis virus is related to the rabies virus and could be effective in fighting cancer. Learn about the ... Anthony van den Pol, used an existing virus related to rabies, the vesicular stomatitis virus -- as a weapon against cancerous ... The vesicular stomatitis virus, on the other hand, was able to pass through this barrier. ...
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Vesicular Stomatitis. #section tr td {vertical-align:text-top;}. SECTION I - Full Virus Name and Prototype Number. Prototype ...
Recombinant vesicular stomatitis viruses from DNA. N D Lawson, E A Stillman, M A Whitt, and J K Rose ... Vesicular Stomatitis Virus as a Vector To Deliver Virus-Like Particles of Human Norovirus: a New Vaccine Candidate against an ... Vesicular Stomatitis Virus-Based Therapeutic Vaccination Targeted to the E1, E2, E6, and E7 Proteins of Cottontail Rabbit ... A Vesicular Stomatitis Virus-Based Hepatitis B Virus Vaccine Vector Provides Protection against Challenge in a Single Dose ...
Denture stomatitis is a common oral mucosal lesion in the United States and Western Europe. Prevalence rates of 2. ... encoded search term (Denture Stomatitis) and Denture Stomatitis What to Read Next on Medscape. Related Conditions and Diseases ... Denture stomatitis: a role for Candida biofilms. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul. 98(1):53-9. [ ... Denture stomatitis is a common oral mucosal lesion in the United States and Western Europe. Prevalence rates of 2.5-18.3% in ...
... denture stomatitis, inflammatory papillary hyperplasia and chronic atrophic candidosis. The term denture stomatitis will be ... In treating Stomatitis, the available treatment is applied differently, depending on the cause of the disease. In most cases ... Although denture stomatitis and angular chelitis usually do not reflect a serious predisposing disease or abnormality , with ... Strains of genus Candida, in particular Candida Albicans , may cause denture stomatitis. Still this condition is not a specific ...
The causes of stomatitis vary and can include injury to the mouth, allergy, and infection. ... Stomatitis Stomatitis Speaker Inflammation of the mucous membranes of the mouth, such as the gums or lips. The causes of ... stomatitis vary and can include injury to the mouth, allergy, and infection. ...
... Gastritis and peptic ulcer. Acute diarrhoea Stomatitis. Inflammation of the oral mucosa, with or without infection ... Angular stomatitis of the lips: deficiencies in iron and various vitamins: multivitamins and/or ferrous sulphate +folic acid . ... Hemorrhagic stomatitis with bone and joint pains in the lower limbs (due to subperiosteal hemorrages). Caused by dietary ...
Angular stomatitis definition at, a free online dictionary with pronunciation, synonyms and translation. Look it ...
stomatitis synonyms, stomatitis pronunciation, stomatitis translation, English dictionary definition of stomatitis. n. ... Related to stomatitis: herpetic stomatitis, angular stomatitis. sto·ma·ti·tis. (stō′mə-tī′tĭs). n.. Inflammation of the mucous ... Stomatitis - definition of stomatitis by The Free Dictionary ... stomatitis - inflammation of the mucous membrane of the mouth. inflammation, redness, rubor - a response of body tissues to ...
Definition of vesicular stomatitis virus. Provided by Stedmans medical dictionary and Includes medical terms and ... vesicular stomatitis virus. Definition: an RNA virus of the genus Vesiculovirus, in the family Rhabdoviridae, causing vesicular ...
Herpetic stomatitis is an infectious disease that spreads through bodily fluids or direct contact. The disease is most ... Stomatitis means "inflammation of the mouth." With herpetic stomatitis, the mucous lining of the cheeks, tongue, lips and roof ... Herpetic stomatitis is a recurrent disease. The disease is caused by herpes simplex virus (HSV) and is the most common viral ... Stomatitis affects the mouth and lips. The virus can be dormant in the body and recur with these allergy, fatigue, respiratory ...
... and efficacy when used to treat or reduce the symptoms of stomatitis ... Looking for medication to treat stomatitis? Find a list of current medications, their possible side effects, dosage, ... Below is a list of common medications used to treat or reduce the symptoms of stomatitis. Follow the links to read common uses ...
... Grant Winners. *Paula Waziry, PhD - College of Pharmacy ... increased the expression of the oncolytic Vesicular Stomatitis Virus (VSV), which is an attractive candidate for anticancer ...
... diagnosis and management of denture stomatitis. Extensive reviews of the literature using the Index to Dental Literature, ... The aetiology, diagnosis and management of denture stomatitis. *J Wilson British Dental Journal volume 185, pages380-384(1998) ... This article examines the evidence for the aetiology, diagnosis and management of denture stomatitis. Extensive reviews of the ... Wilson, J. The aetiology, diagnosis and management of denture stomatitis. Br Dent J 185, 380-384 (1998). ...
Stomatitis - Inflammation of the mouth, is clearly explained in Medindia s glossary of medical terms ... Stomatitis - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review Team on ...
Vesicular Stomatitis is a reportable disease; in a suspect case, state and federal animal health authorities will be contacted ... When a case of vesicular stomatitis is confirmed, your state veterinarians office will quarantine the affected farm or ranch. ... p,Vesicular Stomatitis (VS) is a contagious disease that afflicts horses, livestock, wildlife and even humans. The disease is ... Vesicular Stomatitis In Humans Humans can contract vesicular stomatitis from infected horses. Therefore, it is important to ...
gonococcal stomatitis synonyms, gonococcal stomatitis pronunciation, gonococcal stomatitis translation, English dictionary ... definition of gonococcal stomatitis. n. Inflammation of the mucous tissue of the mouth. n inflammation of the mouth stomatitic ... stomatitis. (redirected from gonococcal stomatitis). Also found in: Thesaurus, Medical, Encyclopedia. sto·ma·ti·tis. (stō′mə-tī ... stomatitis - inflammation of the mucous membrane of the mouth. inflammation, redness, rubor - a response of body tissues to ...
... ... How to Treat Stomatitis in Tortoises. Stomatitis is an infection in the mouth, which usually includes swelling, redness, and ... Get a veterinary diagnosis. Stomatitis is a general term for an infection of the mouth, so it can be caused by a variety of ... Stomatitis is an infection in the mouth, which usually includes swelling, redness, and ulcers.[1] This painful condition has a ...
Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis. *Recurrent Aphthous Stomatitis ... Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis. *Recurrent Aphthous Stomatitis ... Therapeutic Effects of Ibuprofen, Diphenhydramine and Aluminium MgS on Recurrent Aphthous Stomatitis. *Aphthous Stomatitis ... Pain due to recurrent aphthous stomatitis (canker sores); impact of recurrent aphthous stomatitis on ability to consume a ...
5 new cases of geographic stomatitis are presented and added to a review of 32 similar cases reported in the literature up to ... 5 new cases of geographic stomatitis are presented and added to a review of 32 similar cases reported in the literature up to ... there seems insufficient proof to consider geographic stomatitis an oral manifestation of psoriasis.. ...
Care guide for Tobacco Stomatitis (Ambulatory Care). Includes: possible causes, signs and symptoms, standard treatment options ... for tobacco stomatitis is to stop smoking. The sores usually go away after a few weeks of no smoking. If they do not go away, ... Tobacco stomatitis is most common in people who smoke pipes or who reverse smoke (inhale from the lit end of a cigarette). ... Tobacco stomatitis begins as redness on the hard palate (roof) of your mouth that is darker than usual. Thick white sores or ...
Stomatitis has been seen with increasing frequency the past fifteen months (prior to October 1956). At first I was quite aware ... I have treated as many as six of a family of seven with stomatitis of fluoride origin. The only member of this family who was ... All of the 133 patients showed whitish exudate over the superficially ulcerated lesions with gingivitis and stomatitis (table 3 ... These skin reactions include: perioral dermatitis, stomatitis, and urticaria. Although many dermatologists now consider ...
  • My advice would be to have your veterinarian try VetzLife's Feline Oral Care gel for stomatitis, which may help improve your cat's condition -- and for many cats showing early signs of this condition, actually stop it in its tracks. (
  • You can also read my review on this common feline malady, 'Feline Stomatitis Complex: Preventing and Treating the Oral Plague of Cats,' posted on my website, (
  • However, sometimes we see a more extensive and painful inflammatory condition in the mouths of cats called feline stomatitis. (
  • What is Feline Stomatitis and what are the symptoms? (
  • Feline stomatitis has been known by many names and most recently as Feline Chronic Gingivostomatitis (FCGS). (
  • In a previous article , we discussed extractions as the gold standard treatment of feline stomatitis. (
  • Recall that feline stomatitis is often an immune-mediated disease, due to an aberrant response of the immune system toward component(s) of dental plaque, likely bacterial antigens. (
  • Fentanyl transdermal patches (12.5 or 25 ug/hr) may be used in some feline stomatitis patients where risks of patch ingestion by pets or family members is unlikely. (
  • Feline stomatitis, aka feline lymphoplasmacytic stomatitis, is severe inflammation of the mucous lining of the mouth. (
  • Stomatitis is a painful problem that leads to weight loss, lack of eating, drooling, "hidden cat syndrome," aggression, and a generally miserable feline. (
  • Cats that suffer from kidney disease or diabetes mellitus are also more prone to feline stomatitis. (
  • A complete oral examination is necessary to diagnose feline stomatitis. (
  • Feline stomatitis is defined as inflammation of the mucous membranes of the mouth. (
  • Ongoing studies are pointing to the likelihood that feline stomatitis is a disease of the bone. (
  • Guided Bone Regeneration" is a procedure that is currently being developed as a treatment alternative for feline stomatitis. (
  • Awake oral examination showed moderate to severe inflammation of the gingiva, mucosa and caudal oral cavity consistent with feline stomatitis (Figure 1). (
  • Feline stomatitis is a frustrating disease for which there are no guaranteed cures. (
  • Find out why Feline stomatitis is among the least understood conditions that veterinary practices come across. (
  • The inflammation in feline stomatitis is progressive. (
  • Feline stomatitis, the most painful oral disease in the feline, has many faces and names. (
  • FS has been called lymphocytic plasmacytic stomatitis, gingivostomatitis, immune mediated feline refractory stomatitis and feline generalized oral inflammatory disease. (
  • Laser therapy is controversial in feline stomatitis and I do not recommend it. (
  • No single treatment seems to be appropriate for every patient but the basic principles in treating feline caudal stomatitis involve: plaque control, inflammation control, pain control, and nutritional support. (
  • Considering taking medication to treat stomatitis? (
  • Homeopathy and Traditional Chinese Medicine are holistic treatment modalities that can help treat stomatitis. (
  • Caused by the herpes virus (HSV), the condition is also known as herpes stomatitis. (
  • Herpetic keratoconjunctivitis, a herpes infection of the eye, can be a complication of herpes stomatitis. (
  • The Herpes Stomatitis is also commonly referred to as Stomatitis Herpetic. (
  • What Causes Herpes Stomatitis? (
  • The second form, called Caudal Stomatitis, involves an area at the back of the mouth where the upper and lower jaws come together known as the "fauces. (
  • Caudal stomatitis may be more challenging to treat. (
  • Severe caudal stomatitis and residual rostral stomatitis is seen in a cat that had partial mouth extractions about one year earlier. (
  • In the December 2007 issue of the Journal of Veterinary Dentistry, J. Lewis, A. Tsugawa, and A. Reiter include a case report ["Use of C02 Laser as an Adjunctive Treatment for Caudal Stomatitis in a Cat"] in which the laser was utilized. (
  • Cat with Caudal Stomatitis. (
  • In one study of cats with caudal stomatitis, 60% were cured by extraction and another 20% had enough improvement that medication was able to control the pain and inflammation. (
  • The symptoms of stomatitis usually disappear within one to two weeks. (
  • Below is a list of common medications used to treat or reduce the symptoms of stomatitis. (
  • Malnutrition (improper dietary intake) or malabsorption (poor absorption of nutrients into the body) can lead to nutritional deficiency states, several of which can lead to stomatitis. (
  • Other things that can lead to stomatitis include immune-mediated diseases, ingestion of irritants, foreign bodies (such as plant debris) and systemic diseases such as kidney failure. (
  • There are other maladies that can lead to stomatitis besides a faulty immune system. (
  • Other conditions can cause stomatitis, so investigation and diagnosis are vital to ensure the doctor gives the correct treatment. (
  • Certain cancers can cause stomatitis as well as trauma, plant ingestion, and electric cord burns. (
  • Poisoning with heavy metals, such as lead or mercury , can also cause stomatitis. (
  • Aphthous stomatitis (canker sores) is the recurrent appearance of mouth ulcers in otherwise healthy individuals. (
  • Recurrent Aphthous Stomatitis: Why Do Canker Sores Keep Coming Back? (
  • While the occasional canker sore is one thing, recurrent aphthous stomatitis (RAS) can be even more bothersome. (
  • Canker sores, or aphthous ulcers, are the lesions caused by aphthous stomatitis . (
  • More importantly, we have recently observed that the statin, simvastatin, at very low concentrations, increased the expression of the oncolytic Vesicular Stomatitis Virus (VSV), which is an attractive candidate for anticancer investigation. (
  • Moreover, the incorporation of a tumor-associated antigen within the oncolytic vesicular stomatitis virus increased the levels of activation of naïve T cells against the antigen, which translated into increased antitumor therapy. (
  • This article examines the evidence for the aetiology, diagnosis and management of denture stomatitis. (
  • Wilson, J. The aetiology, diagnosis and management of denture stomatitis. (
  • The search for an alternative treatment modality has led to some studies which consider laser therapy as an option in the management of denture stomatitis. (
  • Shulman JD, Rivera-Hidalgo F, Beach MM. Risk factors associated with denture stomatitis in the United States. (
  • The microorganism that is associated with denture stomatitis is known as Candida albicans, a fungus. (
  • Diagnosis will depend entirely on what is causing the stomatitis. (
  • Guidelines for diagnosis and management of aphthous stomatitis ," Pediatric Infectious Disease Journal, vol. (
  • Nicotine stomatitis is a clinical diagnosis based on the pattern on the palate and typical white 'cracked' appearance with the red dots. (
  • This presentation, given by Santiago Peralta, DVM, DAVDC, at the 2014 ASPCA/Cornell Maddie's ® Shelter Medicine Conference, will review the current knowledge regarding the pathophysiology, diagnosis and treatment of chronic stomatitis in cats. (
  • A biopsy is needed to confirm the diagnosis but this is the characteristic appearance of "plasma cell stomatitis. (
  • The four subtypes of stomatitis are erythemopultaceous, ulcerative, haemorrhagic and hyperkeratotic. (
  • This report concerns an instance of severe ulcerative stomatitis which appeared six days prior to each of 18 consecutive menstrual cycles. (
  • In the first study investigating the origins of a little-known condition called chronic ulcerative stomatitis (CUS), researchers at Tufts University School of Dental Medicine provide evidence that an autoimmune response contributes to the painful oral sores that characterize the disease. (
  • Chronic ulcerative stomatitis is characterized by painful, recurring sores in the mouth. (
  • Vesicular stomatitis is a viral disease which primarily affects horses, cattle, and swine. (
  • Herpetic stomatitis is a viral infection of the mouth that causes sores and ulcers. (
  • Vesicular stomatitis viras (VSV) is a viral agent belonging to the order Mononegavirales, family Rhabdoviridae, genus Vesiculovirus. (
  • Among the various syndromes, the most common was stomatitis (viral blisters in the throat), accounting for 58% of all cases seen. (
  • Working with vesicular stomatitis virus (VSV), a prototype of the NNS RNA viruses, we examined the location of the viral replication machinery and RNA synthesis in cells. (
  • I would very much like to try it on two of our FIV+ cats with stomatitis - one case is severe, one just a little. (
  • In more severe cases, which account for about 1 in 10 of all cases of stomatitis, the sores can last up to 6 weeks. (
  • We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha). (
  • There could be a link between the development of severe aphthous stomatitis and having a weakened immune system. (
  • Stomatitis is a more severe form of oral inflammation involving more than just the gingiva. (
  • Other forms of stomatitis may occasionally cause more severe symptoms, including chills, fever, and headache. (
  • Severe stomatitis can be a side effect of chemotherapy and radiation to the head and neck as treatment for cancer. (
  • Denture stomatitis is considered to be the most prevalent oral lesion amongst denture wearing patients, who may suffer severe discomfort with pain and a burning sensation in the mouth. (
  • Aphthous stomatitis is a common condition characterized by the repeated formation of benign and non-contagious mouth ulcers (aphthae) in otherwise healthy individuals. (
  • Persons with aphthous stomatitis have no detectable systemic symptoms or signs (i.e., outside the mouth). (
  • Stomatitis is inflammation of the mouth. (
  • Stomatitis that reoccurs and includes mouth ulcers is called recurrent aphthous stomatitis (RAS) and is the most common disease affecting the mouth area, with around 5-25 percent of the United States population affected in some way. (
  • Allergic contact stomatitis is less common than allergic contact dermatitis because the mouth is coated in saliva, which washes away antigens and acts as a barrier. (
  • The often relative association of Candida associated denture stomatitis with angular chelitis or glossitis indicated a spread of infection from the denture covered mucosa to the angles of the mouth or the tongue, respectively. (
  • Angular chelitis is often correlated to the presence of Candida associated stomatitis, and it is thought that the infection may start beneath the maxillary denture and from that area spread to the angels of the mouth. (
  • The causes of stomatitis vary and can include injury to the mouth, allergy, and infection. (
  • With herpetic stomatitis, the mucous lining of the cheeks, tongue, lips and roof of the mouth becomes inflamed. (
  • Stomatitis affects the mouth and lips. (
  • Tobacco products and alcohol should not be used during an episode of herpetic stomatitis, as they will further irritate the lining of the mouth. (
  • When vesicular stomatitis occurs in horses, blister-like lesions usually develop on the tongue, mouth lining, nose or lips. (
  • While a horse is suffering from vesicular stomatitis, feeding soft feeds may reduce mouth discomfort. (
  • Stomatitis is an infection in the mouth, which usually includes swelling, redness, and ulcers. (
  • Stomatitis is a general term for an infection of the mouth, so it can be caused by a variety of things. (
  • Eugenol allergy mimicking recurrent aphthous stomatitis and burning mouth syndrome. (
  • Stomatitis into mouth. (
  • Nicotine stomatitis, also often called smoker's palate, is a reaction seen on the roof of the mouth caused by extreme heat in the mouth, most commonly from smoking. (
  • Nicotine stomatitis is usually seen in pipe smokers and reverse cigarette smokers (when the lit end of the cigarette is placed in the mouth). (
  • Nicotine stomatitis is often found on routine examination of the mouth as it usually does not cause any symptoms. (
  • One of these extra-intestinal conditions is aphthous stomatitis , or ulcers in the mouth. (
  • Because aphthous stomatitis may also be worsened by trauma, it is important to take care to not bite or injure the inside of the mouth. (
  • Stomatitis refers to a more generalized inflammation, whereby most and possibly all of the oral tissues including the gums, tongue, inner surfaces of the lips, and/or the floor and roof of the mouth are affected. (
  • In some types of stomatitis the mouth becomes dry, but in others there is excessive salivation. (
  • A biopsy of the mouth is needed to confirm that the problem is actually plasma cell stomatitis and not something of similar appearance but requiring different treatment. (
  • Inflammation of the corners (angles) of the lips is termed angular stomatitis or angular cheilitis. (
  • [ 1 , 2 ] Although patient age and denture quality alone do not predispose individuals this mucosal condition, the odds of developing stomatitis, denture-related hyperplasia, and angular cheilitis are increased almost 3-fold in denture wearers. (
  • Stomatitis is a type of mucositis , a condition defined as pain or inflammation of the mucous membrane. (
  • What is stomatitis/mucositis? (
  • How can I prevent stomatitis/mucositis? (
  • What are common oral health problems that occur as a result of stomatitis/mucositis? (
  • Typically, cats with stomatitis show a widespread and dramatic inflammation of the oral tissue, often spreading into the oropharynx and along the mucosa of the hard palate. (
  • Stomatitis, an inflammation of the oral mucous membranes is a common adverse event associated with mammalian target of rapamycin (mTOR) inhibitors, including everolimus, which is used to treat solid tumors. (
  • The cat on the right has Plasma Cell Stomatitis. (
  • Further, there are metabolic causes of oral ulceration that can mimic plasma cell stomatitis. (
  • The agent that causes vesicular stomatitis, VSV, has a wide host range and can occasionally infect sheep and goats. (
  • In addition to the livestock already mentioned, donkeys, mules, and humans can suffer from the virus that causes vesicular stomatitis (VSV). (
  • Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal diseases, characterised by recurrent painful mucosal ulcers which cause increased salivation and pain during eating, drinking and speaking. (
  • Because stomatitis is an extremely painful condition, cats who have it will often not eat, may paw at their mouths, and might have personality changes. (
  • Brushing the cat's teeth can decrease plaque formation, but it is nearly impossible to brush the teeth of a cat with stomatitis because they are so painful. (
  • A case of aphthous stomatitis that is not very troublesome or painful does not necessarily require a specific visit to a physician. (
  • Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of unknown etiology, characterized by painful ulcers of the oral mucosa affecting 40% of the population. (
  • Stomatitis is often very painful causing a decreased appetite due to the pain. (
  • Working with vesicular stomatitis virus (VSV), we previously showed that a panel of recombinant VSVs carrying mutations at a predicted methyltransferase catalytic site (rVSV-K1651A, -D1762A, and -E1833Q) or S-adenosylmethionine (SAM) binding site (rVSV-G1670A, -G1672A, and -G4A) were defective in cap methylation and were also attenuated for growth in cell culture. (
  • [2] Multiple research studies have attempted to identify a causative organism, but aphthous stomatitis appears to be non-contagious, non-infectious, and not sexually transmissible. (
  • Vesicular Stomatitis (VS) is a contagious disease that afflicts horses, livestock, wildlife and even humans. (
  • The guest veterinarian reviewed several contagious diseases, including vesicular stomatitis. (
  • Aphthous stomatitis is not believed to be contagious and cannot be spread to other people. (
  • Stomatitis in cats is not contagious between cats or other animals. (
  • Denture stomatitis is probably multifactorial in etiology, but it has been speculated that poor oral hygiene together with continuous use of dentures could be the usual cause of this lesion. (
  • The term denture stomatitis will be used with the prefix Candida associated if the yeast candida is involved. (
  • Strains of genus Candida, in particular Candida Albicans , may cause denture stomatitis. (
  • The direct predisposing factor for Candida associated denture stomatitis is the presence of the denture in the oral cavity(box 1). (
  • The more important factors that can modulate host-parasite relationship and increase the susceptibility to Candida associated denture stomatitis may be aging, malnutrition, immunosuppression, radiation therapy, diabetes mellitus and possibly treatment with antibacterial antibiotics. (
  • The animal was kept exclusively on solid ground and fed with vegetables as would be a terrestrial species, which led to chronic malnutrition, dehydration and stress, and subsequently to the overgrowth of the beak and nails, lameness and secondary stomatitis associated with Candida spp. (
  • Denture stomatitis is caused by a yeast or fungus called candida. (
  • The literature indicates that laser therapy may reduce the risk of the development of a drug resistant Candida albicans and could improve the prospects of treatment success for denture stomatitis, However, there remains a need for more research studies on various clinical lasers and wider laser parameters. (
  • The main use is to control the growth of microorganisms on the dentures, especially Candida albicans, thereby preventing denture-related stomatitis. (
  • Herpetic stomatitis is an infection caused by the herpes simplex virus (HSV), or oral herpes . (
  • Aphthous stomatitis is one of the most common diseases of the oral mucosa, and is thought to affect about 20% of the general population to some degree. (
  • Denture stomatitis is a common oral mucosal lesion in the United States and Western Europe. (
  • stomatitis characterized by necrosis of oral tissue. (
  • Based upon the findings of the literature and the results of the present study, there seems insufficient proof to consider geographic stomatitis an oral manifestation of psoriasis. (
  • Your search "stomatitis oral inflammation" did not match any products. (
  • Do you want to show stomatitis oral inflammation or other products of your own company? (
  • Stomatitis medicamentosa is a less common oral lesion that is produced with systemic administration of drugs. (
  • This article includes a case of Stomatitis medicamatosa in a patient who presented with multiple oral ulcerations on oral administration of Carbamazepine used for the treatment of Trigeminal Neuralgia. (
  • The oral reactions to systemic administration of drugs can be broadly classified as non-immunogenic reactions such as gingival hyperplasia due to Dialantin sodium, Heavy metal poisoning, oral ulcerations due to Chemotherpeutic drugs and immunogenic reactions, also referred as Stomatitis medicamentosa [ 2 ]. (
  • Recurrent aphthous stomatitis (RAS), also known as recurrent aphthous ulcer or recurrent oral ulcer, is the most common recurrent oral mucosal lesions. (
  • Cases of aphthous stomatitis that are related to a serious underlying condition such as HIV infection may be treated with oral medication. (
  • 1 The chemical irritation of the oral mucosa with ammonia compound, which is made from nitrogen hydrolysed by urease in saliva, is presumed to cause uraemic stomatitis. (
  • To provide updated information about the use of lasers as an adjunctive therapy for denture stomatitis, the most prevalent oral lesion amongst denture-wearing patients. (
  • Aphthous stomatitis has been associated with other autoimmune diseases, namely systemic lupus erythematosus , Behçet's disease and inflammatory bowel diseases. (
  • Herpetic stomatitis is an infectious disease that spreads through bodily fluids or direct contact. (
  • Herpetic stomatitis is a recurrent disease. (
  • People affected with herpetic stomatitis should be careful about exposing others to the disease. (
  • There are still some questions regarding how vesicular stomatitis is transmitted and why it only occurs sporadically in the U.S. The disease is distributed only in North, Central, and South America, with a greater incidence in warmer regions. (
  • In short, stomatitis in cats can be a very frustrating disease for both people who have cats and veterinarians. (
  • Evidence points to stomatitis being an immune-mediated disease rather than a bacterial infection. (
  • The cause of stomatitis is not completely understood, but the disease is believed to be multi-factorial. (
  • PFAPA syndrome is a chronic disease that is characterized by recurrent episodes of high fever, aphthous stomatitis, pharyngitis, and cervical adenitis. (
  • The causes of stomatitis vary widely, from a mild local irritant to a vitamin deficiency or infection by a possibly dangerous disease-producing organism. (
  • When the inflammation is caused by anemia, vitamin deficiency, or any infection of the body, both the underlying disease and the stomatitis are treated. (
  • Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) [ 1 ] syndrome belongs to the spectrum of autoinflammatory diseases characterized by spontaneous episodes of inflammation which are not accompanied by the usual hallmarks of autoimmunity-high-titer autoantibodies or autoreactive T-cells [ 1 ]. (
  • Stomatitis resulting from certain diseases presents special identifying symptoms. (
  • If you or another adult in the family has a cold sore, it could have spread to your child and caused herpetic stomatitis. (
  • Your child should also avoid other children with herpetic stomatitis. (
  • If your child has herpetic stomatitis, avoid spreading the virus to other children. (
  • When suffering from herpetic stomatitis, avoid hot and cold beverages and foods. (
  • dos Santos RB, Katz J. Nicotinic stomatitis: positive correlation with heat in maté tea drinks and smoking. (
  • Nicotinic stomatitis occurs almost exclusively in pipe smokers and appears on the hard and soft palate. (
  • All the nicotinic stomatitis has cleared up. (
  • Nicotinic stomatitis happens only in areas where the pipe smoke can make contact with the palatal tissues. (
  • The above image shows nicotinic stomatitis in a patient who wears a partial denture which covers the anterior half of the hard palate. (
  • Thus the nicotinic stomatitis is seen only in areas distal to (behind) the plastic flange which has protected the tissues under it from the heat and toxicity of the pipe smoke. (
  • The above image shows an early stage nicotinic stomatitis with heat related lesions. (
  • Nicotinic stomatitis is not considered a pre cancerous condition, however there are exceptions to every rule. (
  • The image above shows nicotinic stomatitis in an elderly man who has been smoking a pipe for many years. (
  • While nicotinic stomatitis is not considered to be pre cancerous, leukoplakia definitely is! (
  • Both leukoplakia and nicotinic stomatitis are composed of keratinized tissue, and the difference in carcinogenicity may, in fact, be due mostly to the differences in the resistances of the tissues on which they are found. (
  • Approximately 20 percent of cases will not be clinically cured by extraction and are categorized as "refractory stomatitis" cases. (
  • Geographic stomatitis and psoriasis. (
  • 5 new cases of geographic stomatitis are presented and added to a review of 32 similar cases reported in the literature up to 1987. (
  • International and Interstate Testing of Animals for Vesicular Stomatitis Virus Antibodies - information sheet provided by the National Veterinary Services Laboratory . (
  • Treatment for stomatitis will depend on the cause. (
  • There is no cure for aphthous stomatitis, and therapies are aimed at alleviating the pain, reducing the inflammation and promoting healing of the ulcers, but there is little evidence of efficacy for any treatment that has been used. (
  • Different antiviral medications are used in treatment of stomatitis, including acyclovir. (
  • If you suspect that your tortoise has stomatitis, you should take it to a veterinarian so that it can get proper treatment, as the earlier you start treatment the easier it is to eliminate the infection. (
  • Part of the treatment for stomatitis will require at home care. (
  • Many therapeutic options, with varying degrees of supporting evidence, are recommended for the treatment of aphthous stomatitis. (
  • [ 110 ] Montelukast is reported to have equal efficacy as prednisone in the treatment of recurrent aphthous stomatitis, with fewer adverse effects. (
  • Sometimes, this treatment is still not enough and the stomatitis persists. (
  • Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). (
  • A gastroenterologist can determine if the ulcers are in fact aphthous stomatitis, in most cases simply by their appearance and if further testing or any treatment is needed. (
  • Mild cases of aphthous stomatitis may not require any treatment as the ulcers will heal on their own. (
  • A specific treatment for aphthous stomatitis, amlexanox, is occasionally prescribed for topical use as well, with published studies showing good effectiveness. (
  • After a stomatitis patient has extractions, don't label that patient as refractory to treatment too soon. (
  • There is no one treatment for stomatitis that is effective on its own. (
  • Uraemic stomatitis promptly improves after treatment of underlying uraemia. (
  • The objective of treatment is to identify, remove, and treat the underlying cause of stomatitis. (
  • The treatment of stomatitis involves treating the underlying cause of the problem if there is one that can be identified. (
  • NEW YORK (Reuters Health) - The results of a small trial suggest that vitamin B12 is a safe, effective, and inexpensive treatment for recurrent aphthous stomatitis (RAS). (
  • Only those articles that dealt with denture stomatitis symptoms, treatment and laser therapy, were selected. (
  • Alternative treatment modalities have therefore been sought and some studies have considered laser therapy as an option in denture stomatitis. (
  • Veterinarians, their clients and those who handle horses, cattle and/or swine are asked to be on the alert for signs of Vesicular Stomatitis (VS) in recently imported animals. (
  • AUSTIN - Vesicular stomatitis (VS) has been detected in five horses in far Southwest Texas, (in Kinney County, southeast of Del Rio, TX). (
  • More than 800 premises in eight states in the USA have recently reported cases of vesicular stomatitis in their horses. (
  • Among the various clinical forms, there is chronic atrophic candidiasis, known as denture stomatitis , which is characterized by erythematous lesions located mainly in the upper palate, which contact the denture base. (
  • The objectives of this review are to determine the clinical effectiveness and safety of topical interventions in the reduction of pain associated with recurrent aphthous stomatitis, a reduction in episode duration, a reduction in episode frequency and improved quality of life. (
  • What are the clinical signs of gingivitis and stomatitis? (
  • In a previously published report, Dr. Volkov's team described the excellent long-term outcomes achieved in their clinical experience of treating recurrent aphthous stomatitis with vitamin B12. (
  • Therefore, researchers sought to conduct a meta-analysis to determine the clinical impact of everolimus-related stomatitis on efficacy and safety. (
  • Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy [published online ahead of print January 11, 2016]. (
  • 28 September 2016 - German drugmaker Boehringer Ingelheim and Austrian biopharmaceutical company ViraTherapeutics have inked a long-term collaboration to jointly develop a next generation oncolytic virus therapy platform and to investigate ViraTherapeutics' lead candidate VSV-GP (Vesicular Stomatitis Virus glycoprotein) alone and in combination with other therapies, the companies said. (
  • A stable cell line expressing a complementary DNA clone encoding the vesicular stomatitis virus glycoprotein fused and formed polykaryons at pH 5.5. (
  • Vesicular Stomatitis Virus (VSV) surveillance is conducted by the State Departments of Agriculture in conjunction with USDA - APHIS - Veterinary Services. (
  • Laboratory Information - Diagnostic samples may be submitted to the National Veterinary Services Laboratory (NVSL) in Ames, Iowa for vesicular stomatitis antibody testing. (
  • Livestock originating from a state that has had vesicular stomatitis diagnosed requires special veterinary statements. (
  • Possible recommendations on how to manage chronic stomatitis at a shelter will be discussed. (
  • gp said it looked like gingivitis stomatitis (something i'd already found on google) which can be a child's reaction to their first coldsore exposure. (
  • Stomatitis isn't the mild inflammation that is present in the overwhelming majority of adult cats' mouths, it goes far beyond gingivitis or even periodontitis. (
  • What are gingivitis and stomatitis? (
  • How are gingivitis and stomatitis treated? (
  • What is the prognosis for gingivitis and stomatitis? (
  • Both gingivitis and glossitis are forms of stomatitis. (
  • To: [email protected] Sent: Thursday, August 23, 2012 6:17 PM Subject: Re: [Felvtalk] Stomatitis Thank you - looking at it, I honestly don't believe that I would be able to manage giving it all to the 2 very skittish FIV+ cats, maybe one day… But I will file it away to use on cats who would allow me to do this! (
  • One reported cause of stomatitis is the bacterium Bartonella henselae, which is certainly present in some cats with stomatitis, but is also present in a lot of cats without stomatitis. (
  • Daily tooth brushing would help decrease plaque accumulation, but brushing is difficult in stomatitis cats-an understatement! (
  • What causes stomatitis in cats? (
  • Although any cat (or dog for that matter) can develop stomatitis, mature cats and certain purebreds such as Siamese , Persian , and Abyssinians are more likely to develop this condition than others. (
  • Because cats with stomatitis become severely allergic to the plaque on their teeth, professional teeth scaling and cleaning above and below the gum line is often a starting point. (
  • Talk to your veterinarian to learn the specific signs and symptoms of vesicular stomatitis that may affect the livestock breed(s) on your farm. (
  • South Dakota's Animal Industry Board says two cases of vesicular stomatitis virus have been confirmed in livestock in the western part of the state. (
  • Georgia has rules in place to restrict the movement of livestock from a vesicular stomatitis positive premise. (
  • Attacks characterized by abrupt onset of fever, malaise, chills, aphthous stomatitis, pharyngitis, headache, and tender cervical adenopathy occur at 4- to 6-week intervals over periods of years. (
  • Vesicular stomatitis outbreaks occur periodically in the United States. (
  • This information will help you understand how side effects, such as Stomatitis, can occur, and what you can do about them. (
  • Curcumin: This agent has been suggested as promising for recurrent aphthous stomatitis, with good efficacy reported for relieving pain and reducing ulcer size. (
  • What is Recurrent Aphthous Stomatitis? (
  • What Does Recurrent Aphthous Stomatitis Look Like? (
  • The cause of recurrent aphthous stomatitis is unknown and over the years a variety of treatments, including adhesive pastes, antiseptics, vitamins, herbs, and steroids have been tested. (
  • Allergic contact stomatitis (also termed "allergic gingivostomatitis" or "allergic contact gingivostomatitis") is a type IV (delayed) hypersensitivity reaction that occurs in susceptible atopic individuals when allergens penetrate the skin or mucosa. (
  • Here, we show that CD8+ T cells are critical for the efficacy of intratumoral vesicular stomatitis virus virotherapy and are induced against both virally encoded and tumor-associated immunodominant epitopes. (