AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
SterolsSterol 14-DemethylasePhytosterolsSterol Regulatory Element Binding Protein 1ErgosterolSterol Regulatory Element Binding Protein 2StigmasterolCholestadienolsCholesterolLanosterolDesmosterolCholestenesSterol Regulatory Element Binding ProteinsDehydrocholesterolsSqualeneCholestanesCholestanetriol 26-MonooxygenaseHydroxymethylglutaryl CoA ReductasesHydroxycholesterolsSterol O-AcyltransferaseMevalonic AcidCCAAT-Enhancer-Binding ProteinsSteroid IsomerasesXanthomatosis, CerebrotendinousSmith-Lemli-Opitz SyndromeTriparanolBile Acids and SaltsChromatography, Gastrans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane DihydrochlorideEstersCholestenonesXanthomatosisOxidoreductasesLiverAzolesSteroid HydroxylasesFarnesyl-Diphosphate FarnesyltransferaseLipidsLovastatinChromatography, Thin LayerOxidoreductases Acting on CH-CH Group DonorsHydroxymethylglutaryl-CoA SynthaseCholestyramine ResinEsterificationFilipinLipid MetabolismATP-Binding Cassette TransportersAnticholesteremic AgentsLipid Metabolism, Inborn ErrorsCytochrome P-450 Enzyme SystemCholesterol, DietaryGas Chromatography-Mass SpectrometryCholestanolsLipoproteinsAcetatesFatty Acids14-alpha Demethylase InhibitorsSaccharomyces cerevisiaeFungicides, IndustrialKetocholesterolsSterol EsteraseMembrane LipidsTranscription FactorsIntestinal AbsorptionSteroidsReceptors, LDLDNA-Binding ProteinsMolecular Sequence DataAntifungal AgentsNystatinCarrier ProteinsAcetyl-CoA C-AcetyltransferasePhospholipidsFecesCricetinaeSteroid 12-alpha-Hydroxylase
Sterols
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
Sterol 14-Demethylase
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Phytosterols
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
Sterol Regulatory Element Binding Protein 1
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Ergosterol
A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Sterol Regulatory Element Binding Protein 2
A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.
Stigmasterol
Cholestadienols
Cholestadiene derivatives containing a hydroxy group anywhere in the molecule.
Cholesterol
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Lanosterol
A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
Desmosterol
An intermediate in the synthesis of cholesterol.
Cholestenes
Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.
Sterol Regulatory Element Binding Proteins
Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Dehydrocholesterols
Cholesterol derivatives having an additional double bond in any position. 24-Dehydrocholesterol is DESMOSTEROL. The other most prevalent dehydrocholesterol is the 7-isomer. This compound is a precursor of cholesterol and of vitamin D3.
Squalene
Cholestanes
Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.
Cholestanetriol 26-Monooxygenase
An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol intermediates such as the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol.
Hydroxymethylglutaryl CoA Reductases
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
Hydroxycholesterols
Cholesterol which is substituted by a hydroxy group in any position.
Sterol O-Acyltransferase
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
Mevalonic Acid
CCAAT-Enhancer-Binding Proteins
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Steroid Isomerases
Enzymes that catalyze the transposition of double bond(s) in a steroid molecule. EC 5.3.3.
Xanthomatosis, Cerebrotendinous
An autosomal recessive lipid storage disorder due to mutation of the gene CYP27A1 encoding a CHOLESTANETRIOL 26-MONOOXYGENASE. It is characterized by large deposits of CHOLESTEROL and CHOLESTANOL in various tissues resulting in xanthomatous swelling of tendons, early CATARACT, and progressive neurological symptoms.
Smith-Lemli-Opitz Syndrome
An autosomal recessive disorder of CHOLESTEROL metabolism. It is caused by a deficiency of 7-dehydrocholesterol reductase, the enzyme that converts 7-dehydrocholesterol to cholesterol, leading to an abnormally low plasma cholesterol. This syndrome is characterized by multiple CONGENITAL ABNORMALITIES, growth deficiency, and INTELLECTUAL DISABILITY.
Triparanol
Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.
Bile Acids and Salts
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Chromatography, Gas
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
An anticholesteremic agent that inhibits sterol biosynthesis in animals.
Esters
Cholestenones
CHOLESTENES with one or more double bonds and substituted by any number of keto groups.
Xanthomatosis
A condition marked by the development of widespread xanthomas, yellow tumor-like structures filled with lipid deposits. Xanthomas can be found in a variety of tissues including the SKIN; TENDONS; joints of KNEES and ELBOWS. Xanthomatosis is associated with disturbance of LIPID METABOLISM and formation of FOAM CELLS.
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Azoles
Five membered rings containing a NITROGEN atom.
Steroid Hydroxylases
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Farnesyl-Diphosphate Farnesyltransferase
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lovastatin
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Chromatography, Thin Layer
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Oxidoreductases Acting on CH-CH Group Donors
A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.
Hydroxymethylglutaryl-CoA Synthase
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
Cholestyramine Resin
A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.
Esterification
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
Filipin
A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.
Lipid Metabolism
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
ATP-Binding Cassette Transporters
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
Anticholesteremic Agents
Substances used to lower plasma CHOLESTEROL levels.
Lipid Metabolism, Inborn Errors
Errors in the metabolism of LIPIDS resulting from inborn genetic MUTATIONS that are heritable.
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Cholesterol, Dietary
Cholesterol present in food, especially in animal products.
Gas Chromatography-Mass Spectrometry
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Cholestanols
Cholestanes substituted in any position with one or more hydroxy groups. They are found in feces and bile. In contrast to bile acids and salts, they are not reabsorbed.
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Acetates
Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.
Fatty Acids
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
14-alpha Demethylase Inhibitors
Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.
Saccharomyces cerevisiae
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Fungicides, Industrial
Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.
Ketocholesterols
Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.
Sterol Esterase
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Intestinal Absorption
Uptake of substances through the lining of the INTESTINES.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Receptors, LDL
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Antifungal Agents
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Nystatin
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Acetyl-CoA C-Acetyltransferase
An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enzymes called thiolase or thiolase-I have referred to this activity or to the activity of ACETYL-COA C-ACYLTRANSFERASE.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Feces
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Cricetinae
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Steroid 12-alpha-Hydroxylase
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter. (1/1766)

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a key regulatory enzyme in the pathway for endogenous cholesterol synthesis, is a target for negative feedback regulation by cholesterol. When cellular sterol levels are low, the sterol regulatory element-binding proteins (SREBPs) are released from the endoplasmic reticulum membrane, allowing them to translocate to the nucleus and activate SREBP target genes. However, in all SREBP-regulated promoters studied to date, additional co-regulatory transcription factors are required for sterol-regulated activation of transcription. We have previously shown that, in addition to SREBPs, NF-Y/CBF is required for sterol-regulated transcription of HMG-CoA synthase. This heterotrimeric transcription factor has recently been shown to function as a co-regulator in several other SREBP-regulated promoters, as well. In addition to cis-acting sites for both SREBP and NF-Y/CBF, the sterol regulatory region of the synthase promoter also contains a consensus cAMP response element (CRE), an element that binds members of the CREB/ATF family of transcription factors. Here, we show that this consensus CRE is essential for sterol-regulated transcription of the synthase promoter. Using in vitro binding assays, we also demonstrate that CREB binds to this CRE, and mutations within the CRE that result in a loss of CREB binding also result in a loss of sterol-regulated transcription. We further show that efficient activation of the synthase promoter in Drosophila SL2 cells requires the simultaneous expression of all three factors: SREBPs, NF-Y/CBF, and CREB. To date this is the first promoter shown to require CREB for efficient sterol-regulated transcription, and to require two different co-regulatory factors in addition to SREBPs for maximal activation.  (+info)

Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action. (2/1766)

The hypocholesterolemic activities of pamaqueside and tiqueside, two structurally similar saponins, were evaluated in cholesterol-fed rabbits. The pharmacological profiles of the saponins were virtually identical: both dose-dependently decreased the intestinal absorption of labeled cholesterol 25-75%, increased fecal neutral sterol excretion up to 2.5-fold, and decreased hepatic cholesterol content 10-55%. High doses of pamaqueside (>5 mg/kg) or tiqueside (>125 mg/kg) completely prevented hypercholesterolemia. Decreases in plasma and hepatic cholesterol levels were strongly correlated with increased neutral sterol excretion. Ratios of neutral sterol excreted to pamaqueside administered were greater than 1:1 at all doses, in opposition to the formation of a stoichiometric complex previously suggested for tiqueside and other saponins. Ratios in tiqueside-treated rabbits were less than unity, a reflection of its lower potency. Pamaqueside-treated rabbits exhibited a more rapid decline in plasma cholesterol concentrations than control animals fed a cholesterol-free diet, indicating that the compound also inhibited the absorption of biliary cholesterol. Intravenous administration of pamaqueside had no effect on plasma cholesterol levels despite plasma levels twice those observed in rabbits given pamaqueside orally. These data indicate that pamaqueside and tiqueside induce hypocholesterolemia by blocking lumenal cholesterol absorption via a mechanism that apparently differs from the stoichiometric complexation of cholesterol hypothesized for other saponins.  (+info)

High-affinity binding of very-long-chain fatty acyl-CoA esters to the peroxisomal non-specific lipid-transfer protein (sterol carrier protein-2). (3/1766)

Binding of fluorescent fatty acids to bovine liver non-specific lipid-transfer protein (nsL-TP) was assessed by measuring fluorescence resonance energy transfer (FRET) between the single tryptophan residue of nsL-TP and the fluorophore. Upon addition of pyrene dodecanoic acid (Pyr-C12) and cis-parinaric acid to nsL-TP, FRET was observed indicating that these fatty acids were accommodated in the lipid binding site closely positioned to the tryptophan residue. Substantial binding was observed only when these fatty acids were presented in the monomeric form complexed to beta-cyclodextrin. As shown by time-resolved fluorescence measurements, translocation of Pyr-C12 from the Pyr-C12-beta-cyclodextrin complex to nsL-TP changed dramatically the direct molecular environment of the pyrene moiety: i.e. the fluorescence lifetime of the directly excited pyrene increased at least by 25% and a distinct rotational correlation time of 7 ns was observed. In order to evaluate the affinity of nsL-TP for intermediates of the beta-oxidation pathway, a binding assay was developed based on the ability of fatty acyl derivatives to displace Pyr-C12 from the lipid binding site as reflected by the reduction of FRET. Hexadecanoyl-CoA and 2-hexadecenoyl-CoA were found to bind readily to nsL-TP, whereas 3-hydroxyhexadecanoyl-CoA and 3-ketohexadecanoyl-CoA bound poorly. The highest affinities were observed for the very-long-chain fatty acyl-CoA esters (24:0-CoA, 26:0-CoA) and their enoyl derivatives (24:1-CoA, 26:1-CoA). Binding of non-esterified hexadecanoic acid and tetracosanoic acid (24:0) was negligible.  (+info)

Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. (4/1766)

We investigated the changes of cholesterol and non-cholesterol sterol metabolism during plant stanol ester margarine feeding in 153 hypercholesterolemic subjects. Rapeseed oil (canola oil) margarine without (n = 51) and with (n = 102) stanol (2 or 3 g/day) ester was used for 1 year. Serum sterols were analyzed with gas-liquid chromatography. The latter showed a small increase in sitostanol peak during stanol ester margarine eating. Cholestanol, campesterol, and sitosterol proportions to cholesterol were significantly reduced by 5-39% (P < 0.05 or less for all) by stanol esters; the higher their baseline proportions the higher were their reductions. The precursor sterol proportions were significantly increased by 10- 46%, and their high baseline levels predicted low reduction of serum cholesterol. The decrease of the scheduled stanol dose from 3 to 2 g/day after 6-month feeding increased serum cholesterol by 5% (P < 0. 001) and serum plant sterol proportions by 8-13% (P < 0.001), but had no consistent effect on precursor sterols. In twelve subjects, the 12-month level of LDL cholesterol exceeded that of baseline; the non-cholesterol sterol proportions suggested that stimulated synthesis with relatively weak absorption inhibition contributed to the non-responsiveness of these subjects. In conclusion, plant stanol ester feeding lowers serum cholesterol in about 88% of subjects, decreases the non-cholesterol sterols that reflect cholesterol absorption, increases the sterols that reflect cholesterol synthesis, but also slightly increases serum plant stanols. Low synthesis and high absorption efficiency of cholesterol results in the greatest benefit from stanol ester consumption.  (+info)

Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. (5/1766)

Phosphomevalonate kinase catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate and was originally believed to be a cytosolic enzyme. In this study we have localized the phosphomevalonate kinase gene to chromosome 1p13-1q22-23 and present a genomic map indicating that the gene spans more than 8.4 kb in the human genome. Furthermore, we show that message levels and enzyme activity of rat liver phosphomevalonate kinase are regulated in response to dietary sterol levels and that this regulation is coordinate with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. In addition, we demonstrate that phosphomevalonate kinase is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle.  (+info)

Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. (6/1766)

In vertebrates, the formation of raft lipid microdomains plays an important part in both polarized protein sorting and signal transduction. To establish a system in which raft-dependent processes could be studied genetically, we have analyzed the protein and lipid composition of these microdomains in Drosophila melanogaster. Using mass spectrometry, we identified the phospholipids, sphingolipids, and sterols present in Drosophila membranes. Despite chemical differences between Drosophila and mammalian lipids, their structure suggests that the biophysical properties that allow raft formation have been preserved. Consistent with this, we have identified a detergent-insoluble fraction of Drosophila membranes that, like mammalian rafts, is rich in sterol, sphingolipids, and glycosylphosphatidylinositol-linked proteins. We show that the sterol-linked Hedgehog N-terminal fragment associates specifically with this detergent-insoluble membrane fraction. Our findings demonstrate that raft formation is preserved across widely separated phyla in organisms with different lipid structures. They further suggest sterol modification as a novel mechanism for targeting proteins to raft membranes and raise the possibility that signaling and polarized intracellular transport of Hedgehog are based on raft association.  (+info)

Non-insulin-dependent diabetes mellitus and hypertriglyceridemia impair lipoprotein metabolism in chronic hemodialysis patients. (7/1766)

Patients with diabetes mellitus undergoing chronic hemodialysis treatment have the worst outcome on dialysis due to an increased rate of cardiovascular complications. Nearly all patients present with dyslipidemia, a prominent vascular risk factor, probably responsible for the high rate of vascular injury. Since both uremia and diabetes predispose to hypertriglyceridemia, the present study was conducted to investigate the influence of diabetes mellitus and/or hypertriglyceridemia on lipoprotein metabolism in hemodialysis patients. LDL was isolated and characterized from hyper- and normotriglyceridemic diabetic and nondiabetic hemodialysis patients (n = 40; 10 in each group); also, LDL-receptor-dependent uptake and intracellular cholesterol metabolism were studied in HepG2 cells. In addition, scavenger-receptor-mediated uptake was examined in mouse peritoneal macrophages. LDL isolated from nondiabetic normotriglyceridemic hemodialysis patients exhibited impaired cellular uptake via the LDL receptor. Additionally, intracellular sterol synthesis was less inhibited and cholesterol esterification was reduced compared with LDL from healthy control subjects. Reduction of catabolic capacities was more marked in hemodialysis patients who were either diabetic or hypertriglyceridemic and even more pronounced in patients presenting with a combination of both diabetes and hypertriglyceridemia. Hypertriglyceridemic and diabetic patients showed reduced lipase activity and increased LDL oxidation. Furthermore, they accumulated a fraction of small, dense LDL, and LDL was predominantly taken up via the scavenger-receptor pathway in peritoneal macrophages. This study elucidates the distinct influence of diabetes and/or hypertriglyceridemia in hemodialysis patients on cellular LDL metabolism via specific and nonspecific metabolic pathways. Furthermore, it underscores the cumulative impact of these pathologic entities on impairment of lipoprotein metabolism and increase of cardiovascular risk.  (+info)

The interaction of lipodepsipeptide toxins from Pseudomonas syringae pv. syringae with biological and model membranes: a comparison of syringotoxin, syringomycin, and two syringopeptins. (8/1766)

Pseudomonas syringae pv. syringae produces two groups of cyclic lipodepsipeptides (LDPs): the nona-peptides syringomycins, syringostatins, and syringotoxin (ST), and the more complex syringopeptins composed of either 22 or 25 amino acid residues (SP22 and SP25). Both classes of peptides significantly contribute to bacterial pathogenesis and their primary target of action seems to be the plasma membrane. We studied and compared the activity of some members of these two classes of LDPs on red blood cells and on model membranes (monolayers and unilamellar vesicles). All peptides induced red blood cell hemolysis. The mechanism was apparently that of a colloid-osmotic shock caused by the formation of pores, as it could be prevented by osmoticants of adequate size. Application of the Renkin equation indicated a radius of approximately 1 nm for the lesions formed by syringopeptins SP22A and SP25A, whereas those formed by syringomycin E (SRE) had a variable, dose-dependent size ranging from 0.7 up to 1.7 nm. All tested LDPs displayed surface activity, forming peptide monolayers with average molecular areas of 1.2 nm2 (SRE), 1.5 nm2 (SP22A), and 1.3 nm2 (SP25A). They also partitioned into preformed lipid monolayers occupying molecular areas that ranged from 0.6 to 1.7 nm2 depending on the peptide and the lipid composition of the film. These LDPs formed channels in lipid vesicles as indicated by the release of an entrapped fluorescent dye (calcein). The extent of permeabilization was dependent on the concentration of the peptide and the composition of the lipid vesicles, with a preference for those containing a sterol. From the dose dependence of the permeabilization it was inferred that LDPs increased membrane permeability by forming oligomeric channels containing from four to seven monomers. On average, syringopeptin oligomers were smaller than SRE and ST oligomers.  (+info)

Involvement of heme biosynthesis in control of sterol uptake by Sacch by T A. Lewis, F R. Taylor et al.Involvement of heme biosynthesis in control of sterol uptake by Sacch by T A. Lewis, F R. Taylor et al.
Wild-type Saccharomyces cerevisiae do not accumulate exogenous sterols under aerobic conditions, and a mutant allele conferring sterol auxotrophy (erg7) could be isolated only in strains with a heme deficiency. delta-Aminolevulinic acid (ALA) fed to a hem1 (ALA synthetase-) erg7 (2,3-oxidosqualene cyclase-) sterol-auxotrophic strain of S. cerevisiae inhibited sterol uptake, and growth was negatively affected when intracellular sterol was depleted. The inhibition of sterol uptake (and growth of sterol auxotrophs) by ALA was dependent on the ability to synthesize heme from ALA. A procedure was developed which allowed selection of strains which would take up exogenous sterols but had no apparent defect in heme or ergosterol biosynthesis. One of these sterol uptake control mutants possessed an allele which allowed phenotypic expression of sterol auxotrophy in a heme-competent background.
https://mouseion.jax.org/stfb1980_1989/649/
Marine Drugs | Free Full-Text | Sterol Ring System Oxidation Pattern in Marine Sponges | NotesMarine Drugs | Free Full-Text | Sterol Ring System Oxidation Pattern in Marine Sponges | Notes
The marine sponges (Porifera) are a unique group of sedentary organisms from which several novel natural products are reported, many of which have useful biological activities. In producing unusual sterols, they occupy a preeminent position among the various groups of organisms. The polar sterols of sponges reported as at the end of the year 2002 number about 250; their ring structure changing a hundred times. The oxidation pattern in the sterol ring system, from the point of view of biogenesis seems to be mainly of four types. Each sponge species is able to produce sterols fitting into one of the four main biogenetic pathways viz., (i) 3β-hydroxy-Δ5-sterol pathway, (ii) 3β-hydroxy-Δ7-sterol pathway, (iii) 3β-hydroxy-Δ5,7-sterol pathway, and (iv) 3α-hydroxy sterol pathway.
http://www.mdpi.com/1660-3397/3/3/84/notes
The Requirement of Sterol and Various Sterol Precursors in Free-Living Nematodes » Brill OnlineThe Requirement of Sterol and Various Sterol Precursors in Free-Living Nematodes » Brill Online
The quantitative sterol requirements were studied in C. briggsae, C. elegans (Be), C. elegans (Br), and T. aceti. It was shown that all four nematodes had similar minimal sterol requirements (0.1-2.0 μg/ml) and toxicity appeared in T. aceti at 50 μg/ml. Cholesterol and five precursors were tested for population growth. We found that acetic acid, DLmevalonic acid lactone, and farnesol did not support population growth; while squalene, lanosterol, and cholesterol supported significant population growth in all four nematodes. Our results suggest that the major metabolic block in the pathway of sterol biosynthesis occurs between the step of farnesol and squalene.
http://booksandjournals.brillonline.com/content/journals/10.1163/187529277x00228
Fatty Acid and Sterol Profiles of Olive Oil Produced in the US - New Report from the UC Davis Olive Center - UC Davis Olive...Fatty Acid and Sterol Profiles of Olive Oil Produced in the US - New Report from the UC Davis Olive Center - UC Davis Olive...
The United States Department of Agriculture (USDA) has established voluntary olive oil standards, which are based largely on standards adopted by the International Olive Council (IOC). USDA standards include an acceptable range for each fatty acid and sterol, seeking to ensure that olive oil is not adulterated with other types of oils. In this study, the UC Davis Olive Center collected US-grown olives and processed the olives at campus facilities to determine the extent that the oils would be accommodated by USDA standards for fatty acid and sterol profiles.
http://olivecenter.ucdavis.edu/news/news-items/fatty-acid-and-sterol-profiles-of-olive-oil-produced-in-the-us-2013-new-report-from-the-uc-davis-olive-center
Serval - The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen...Serval - The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen...
In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including the p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis that are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized and need to be imported into cells. Here, we show that Ste20, Cla4, and Skm1 form a complex with Sut1, a transcriptional regulator that promotes sterol uptake. All three PAKs can translocate into the nucleus and down-regulate the expression of genes involved in sterol uptake, including the Sut1 targets AUS1 and DAN1 by a novel mechanism. Consistently, deletion of either STE20, CLA4, or SKM1 results in an increased sterol influx and PAK overexpression inhibits sterol uptake. For Ste20, we demonstrate that the down-regulation of gene expression requires nuclear localization and kinase activity of Ste20. Furthermore, the Ste20
https://serval.unil.ch/en/notice/serval:BIB_271A8D35F435
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues | JCBLipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues | JCB
In this study, we demonstrate that yeast ORPs can interact with two membranes simultaneously and facilitate regulated sterol transfer by a novel mechanism. Using Osh4p as a representative Osh protein, we identified a membrane-binding site on Osh4p that is distal to the membrane-binding surface near the mouth of the sterol-binding pocket. Our findings suggest that lipid content of the liposome interacting with the distal membrane-binding surface affects the rate of sterol extraction from and delivery to the second liposome. We confirmed the functional importance of the distal membrane-binding surface of Osh4p by altering it and showing that the mutant protein cannot replace the wild-type protein or facilitate sterol transfer in cells and that it is insensitive to the stimulatory effect of PI(4,5)P2 on sterol transfer in vitro. Because all yeast ORDs can bind two membranes simultaneously, they likely all have similar regulatory distal membrane-binding surfaces, although they almost certainly ...
http://jcb.rupress.org/content/187/6/889
Natural Sterol Complex 180 Tabs - Universal Natural Sterol ComplexNatural Sterol Complex 180 Tabs - Universal Natural Sterol Complex
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Sterols and Stanols - Nature MadeSterols and Stanols - Nature Made
Sterols and stanols stem from plants. Theyre actually components of plant membranes that are very similar to cholesterol. In humans, cholesterol has a cell function similar to what sterols and stanols have in plants. Because sterols and stanols have a similar molecular structure to cholesterol, they block cholesterol receptors and help prevent the absorption of cholesterol. Sterols and stanols are naturally present in many fruits, vegetables, seeds, cereals, and legumes. Eating more of those foods is a great idea because it may lower blood cholesterol levels. But getting enough sterols and stanols through diet alone is nearly impossible. If your plates already full and youre not getting the sterols and stanols you need, you can get help in a supplement like CholestOff too. Now you know the role sterols and stanols play in your heart health. ...
http://www.naturemade.com/resource-center/articles-and-videos/videos/sterols-and-stanols
Sterol dynamics of heterotrophic Tetraselmis suecica and its nutritional implication in the bivalve aquaculture | UMR BOREASterol dynamics of heterotrophic Tetraselmis suecica and its nutritional implication in the bivalve aquaculture | UMR BOREA
Employment of heterotrophic culture of microalgal foods in the hatchery-based seed production of oysters is still controversial because some algae produced using the method appear to loose sterols, a key nutritional factor for bivalve growth. We traced the changes in sterol content of Tetraselmis suecica growing under photoautotrophic and heterotrophic conditions with the aid of gas chromatography (GC) and GC2013mass spectrometry. The photoautotrophic T. suecica at the mid-logarithmic growth phase contained six major (cholesta-5,22-dien-303B2-ol, ergost-5-en-303B2-ol, cholest-5-en-303B2-ol, 24-methylcholesta-5,22-dien-303B2-ol, 24-methylcholesta-5,24-dien-303B2-ol, and 24-ethylchlolesta-5,24-dien-303B2-ol) and two minor sterols (24-methylcholesta-5-en-303B2-ol and 24-ethylchlolesta-5en-303B2-ol). In the comparison of algal growth and sterol level, photoautotrophic alga appeared to need higher amounts of major sterols for cell growth over heterotrophic alga. These findings, that heterotrophic ...
https://borea.mnhn.fr/fr/sterol-dynamics-heterotrophic-tetraselmis-suecica-and-its-nutritional-implication-bivalve
Lipids: Fatty Acids, Sterols, and Triglycerides Explained / Nutrition / FatsLipids: Fatty Acids, Sterols, and Triglycerides Explained / Nutrition / Fats
You may recognize the term sterol from the word cholesterol. A sterol is actually a subgroup of steroids that occur naturally in both plants and animals and function both as hormones as well as part of the structure in cells. Sterols are a critical part of digestion in the form of bile salts and also are found in the cell membrane, or outer wall of cells in the body. Cholesterol is a precursor of vitamin D as well. Foods known as high in dietary cholesterol include egg yolks and shrimp. Plant sterols and stanols are healthy compounds found in plant oils, nuts, seeds and legumes. Consuming plant sterols may block cholesterol from absorbing in the small intestine, helping to decrease bad cholesterol (called LDL) by about 10%. Current research shows that consuming 2-3 grams of plant sterols and stanols contribute to a healthier blood lipid profile ...
https://www.fitday.com/fitness-articles/nutrition/fats/lipids-fatty-acids-sterols-and-triglycerides-explained.html
Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8<...
TY - JOUR. T1 - Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. AU - Wang, Jin. AU - Zhang, Da Wei. AU - Lei, Ying. AU - Xu, Fang. AU - Cohen, Jonathan C.. AU - Hobbs, Helen H.. AU - Xie, Xiao Song. PY - 2008/5/6. Y1 - 2008/5/6. N2 - ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette half-transporters that limit intestinal uptake and promote biliary secretion of neutral sterols. Here, we describe the purification of endogenous G5G8 from mouse liver to near homogeneity. We incorporated the native proteins into membrane vesicles and reconstituted sterol transfer. Native gel electrophoresis, density-gradient ultracentrifugation, and chemical cross-linking studies indicated that the functional native complex is a heterodimer. No higher order oligomeric forms were observed at any stage in the catalytic cycle. Sterol transfer activity by purified native G5G8 was stable, stereospecific, and selective. We also report that G5 but not G8 is S-palmitoylated and that ...
https://utsouthwestern.pure.elsevier.com/en/publications/purification-and-reconstitution-of-sterol-transfer-by-native-mous
Biological Databases and Tools - Sterol Biosynthesis in A. thaliana | Protein Lounge - Sterol Biosynthesis in A. thaliana |...Biological Databases and Tools - Sterol Biosynthesis in A. thaliana | Protein Lounge - Sterol Biosynthesis in A. thaliana |...
Scientifically reviewed pathway providing a current overview of Sterol Biosynthesis in A. thaliana Interactive web-based biological databases and softwares for life-scientists and researchers. - Scientifically reviewed pathway providing a current overview of Sterol Biosynthesis in A. thaliana
https://proteinlounge.com/sterol-biosynthesis-in-thaliana-pg-802.html
Role of sterol metabolism in host response to virus (Durham)Role of sterol metabolism in host response to virus (Durham)
View details for the job vacancy Role of sterol metabolism in host response to virus posted by National Institute of Environmental Health Science on CareerAddict Jobs.
https://jobs.careeraddict.com/post/18928885
Search Results | Journal of Cell Biology | Rockefeller University PressSearch Results | Journal of Cell Biology | Rockefeller University Press
Sterols are unevenly distributed within cellular membranes. How their biosynthetic and transport machineries are organized to generate heterogeneity is largely unknown. We previously showed that the yeast sterol transporter Osh2 is recruited to endoplasmic reticulum (ER)-endocytic contacts to facilitate actin polymerization. We now find that a subset of sterol biosynthetic enzymes also localizes at these contacts and interacts with Osh2 and the endocytic machinery. Following the sterol dynamics, we show that Osh2 extracts sterols from these subdomains, which we name ERSESs (ER sterol exit sites). Further, we demonstrate that coupling of the sterol synthesis and transport machineries is required for endocytosis in mother cells, but not in daughters, where plasma membrane loading with accessible sterols and endocytosis are linked to secretion ...
https://rupress.org/jcb/search-results?f_Authors=Paula+Meler
Sterol Containing Pills, Good For The Heart ( Sterol containing pills a plant consti...)Sterol Containing Pills, Good For The Heart ( Sterol containing pills a plant consti...)
Health,Sterol containing pills a plant constituent can help lower cholester...The researchers analyzed the effects of sterol consumption in thos...Plant sterols were combined with a compound called lecithin to m...Furthermore the beneficial effect of the pill was greater in th...It has been recommended by the National Cholesterol Education Pr...,Sterol,Containing,Pills,,Good,For,The,Heart,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://www.bio-medicine.org/medicine-news/Sterol-Containing-Pills--Good-For-The-Heart-8344-1/
Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status: A pilot study<...Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status: A pilot study<...
TY - JOUR. T1 - Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status. T2 - A pilot study. AU - Hall, Trevor A.. AU - Steiner, Robert D.. AU - Wright, Hollis. AU - Wilmot, Beth. AU - Roullet, Jean Baptiste. AU - Peters, Meaghan. AU - Harris, Michael. N1 - Funding Information: Research reported in this publication was also supported by National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR000128 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: Research reported in this publication was supported by the Northwest Health Foundation under the Mark O. Hatfield Research Fellowship on Autism. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Northwest Health Foundation. PY - 2015/9/1. Y1 - 2015/9/1. N2 - Objective: ...
https://ohsu.pure.elsevier.com/en/publications/lipid-and-sterol-gene-sequence-variation-in-autism-and-correlates-2
Sterol synthesis and low density lipoprotein clearance in vivo in the pregnant rat, placenta, and fetus. Sources for tissue...
TY - JOUR. T1 - Sterol synthesis and low density lipoprotein clearance in vivo in the pregnant rat, placenta, and fetus. Sources for tissue cholesterol during fetal development. AU - Belknap, W. M.. AU - Dietschy, J. M.. PY - 1988. Y1 - 1988. N2 - Whereas the greatest relative increase in body mass occurs during the third trimester of fetal life, the source of the cholesterol that supports this growth is uncertain. These studies used [3H]water and 125I-cellobiose-labeled low density lipoproteins to quantitate absolute rates of cholesterol acquisition in vivo by the fetus of the rat. Preliminary studies demonstrated that [3H]water administered intravenously to the mother rapidly equilibrated with the body pool of water in the fetus and that 22-μg atoms of H from the water pool were incorporated into each micromole of newly synthesized cholesterol. After administration of [3H]water to pregnant rats, the rates of sterol synthesis per 100 g of whole body weight were severalfold higher in the fetus ...
https://utsouthwestern.pure.elsevier.com/en/publications/sterol-synthesis-and-low-density-lipoprotein-clearance-in-vivo-in
Sterol uptake control protein elisa and antibodySterol uptake control protein elisa and antibody
Shop Sterol uptake control protein ELISA Kit, Recombinant Protein and Sterol uptake control protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=sterol-uptake-control-protein
Status Report on the Alteration of Fatty Acid and Sterol Composition in Lipids in Meat, Milk, and Eggs | Fat Content and...Status Report on the Alteration of Fatty Acid and Sterol Composition in Lipids in Meat, Milk, and Eggs | Fat Content and...
Read chapter Status Report on the Alteration of Fatty Acid and Sterol Composition in Lipids in Meat, Milk, and Eggs: Fat Content and Composition of Animal...
https://www.nap.edu/read/22/chapter/14?chapselect=yo&Jump_to_Specified_Page_x=0&Jump_to_Specified_Page_y=0
The effect of sterol composition on the activities of membrane-bound e by Bennett E. OjserkisThe effect of sterol composition on the activities of membrane-bound e by Bennett E. Ojserkis
Ojserkis, Bennett E., The effect of sterol composition on the activities of membrane-bound enzymes in mouse L cells. (1974). Summer and Academic Year Student Reports. 609 ...
https://mouseion.jax.org/strp/609/
5do7 - Proteopedia, life in 3D5do7 - Proteopedia, life in 3D
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC sterol transporter. The structure reveals a new transmembrane fold that is present in a large and functionally diverse superfamily of ABC transporters. The transmembrane domains are coupled to the nucleotide-binding sites by networks of interactions that differ between the active and inactive ATPases, reflecting the catalytic asymmetry of the transporter. The G5G8 structure provides a mechanistic framework for understanding sterol transport and the disruptive effects of mutations ...
http://proteopedia.org/wiki/index.php/5do7
Studies on membrane properties of cholesterol and 3-beta modified sterol analogs</em>...Studies on membrane properties of cholesterol and 3-beta modified sterol analogs</em>...
TY - THES. T1 - Studies on membrane properties of cholesterol and 3-beta modified sterol analogs. AU - Lönnfors, Max. PY - 2014. Y1 - 2014. N2 - Cholesterol (Chol) is an important lipid in cellular membranes functioning both as a membrane fluidity regulator, permeability regulator and co-factor for some membrane proteins, e.g. G-protein coupled receptors. It also participates in the formation of signaling platforms and gives the membrane more mechanical strenght to prevent osmotic lysis of the cell. The sterol structure is very conserved and already minor structural modifications can completely abolish its membrane functions. The right interaction with adjacent lipids and the preference of certain lipid structures over others are also key factors in determining the membrane properties of cholesterol. Because of the many important properties of cholesterol it is of value to understand the forces and structural properties that govern the membrane behavior of this sterol. In this thesis we have ...
https://research.abo.fi/en/publications/studies-on-membrane-properties-of-cholesterol-and-3-beta-modified
STEROLS AND STEROLINS with Arabinogalactan 240s | Health Mart 2000 Ltd
Cholesterol - One of the biggest health problems produced by our modern diet is elevated cholesterol, and one of the best-established uses of plant sterols is in the treatment of cholesterol problems. Recently, sixteen studies involving 590 people with high cholesterol levels have shown that sterols from plants can reduce total cholesterol by an average of 15% and LDL cholesterol (the one that does the harm) by 18%. Beta-sitosterols also fight atherosclerosis (atherosclerotic plaque on artery walls). New Roots Herbals Sterols & Sterolins can play an important role in heart health programs. ...
https://healthmart2000.com/products/sterols-and-sterolins-with-arabinogalactan
Role of the Sterol Carrier Protein-2 N-Terminal Membrane Binding Domain in Sterol Transfer †Role of the Sterol Carrier Protein-2 N-Terminal Membrane Binding Domain in Sterol Transfer †
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi0260536
Livliga® Live Vibrant Blog: What the heck are Stanols and Sterols?Livliga® Live Vibrant Blog: What the heck are Stanols and Sterols?
There are many foods, like butter and orange juice that are now fortified with stanols and sterols which makes it easy to fit into our daily diets. Other foods that are now fortified include cooking oils, salad dressings, milk, yogurt, snack bars, and juices. The main thing is to look on the labels to see which products include the stanols and sterols. An article on the Cleveland Clinic site actually lists products which have added stanols and sterols, Orowheat Whole Grain & Wheat Bread, for instance (clevelandclinic.org). The key is to fit them into your daily menu and calorie plan so you arent over-eating just to add in the benefits they provide. That would be counter productive. A condition I often have to resist ...
http://blog.livligahome.com/2011/09/what-heck-are-stanols-and-sterols.html
ARV1 (YLR242C) Result Summary | BioGRIDARV1 (YLR242C) Result Summary | BioGRID
Cortical ER Protein; Implicated In The Membrane Insertion Of Tail-anchored C-terminal Single Transmembrane Domain Proteins; May Function In Transport Of Glycosylphosphatidylinositol Intermediates Into ER Lumen; Required For Normal Intracellular Sterol Distribution; Human ARV1 Required For Normal Cholesterol And Bile Acid Homeostasis; Similar To Nup120p
https://thebiogrid.org/31509/summary/saccharomyces-cerevisiae/arv1.html
Lipid Disorders and Stanols/Sterols | FoundHealthLipid Disorders and Stanols/Sterols | FoundHealth
Stanols/Sterols can be effective in treating Lipid Disorders. Learn about Stanols/Sterols, see related evidence, and find other smart treatments for Lipid Disorders at FoundHealth.
https://www.foundhealth.com/lipid-disorders/lipid-disorders-and-stanols-sterols
Universal Nutrition Natural Sterol Complex - IllPumpYouUp.comUniversal Nutrition Natural Sterol Complex - IllPumpYouUp.com
Universal Nutrition Natural Sterol Complex was introduced to the bodybuilding community. In that time, this natural alternative to anabolic steroids has remained among our top sellers year after year. Natural Sterol Extreme is loaded with performance aminos, EFAs, energy substrates, and of course, powerful sterols.
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Universal Nutrition Natural Sterol - 120 Capsules Customer Reviews - eVitamins.comUniversal Nutrition Natural Sterol - 120 Capsules Customer Reviews - eVitamins.com
Read the latest Natural Sterol by Universal Nutrition reviews and find the latest results, side effects and user experiences from eVitamins. Have you taken Natural Sterol by Universal Nutrition? Submit your own Natural Sterol review and let the world know what you think.
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Exchange of water for sterol underlies sterol egress from a StARkin domain | eLifeExchange of water for sterol underlies sterol egress from a StARkin domain | eLife
The capture and export of a hydrophobic sterol molecule from the binding pocket of a Lam/GramD1 sterol-binding protein is unexpectedly mediated by water.
https://elifesciences.org/articles/53444
Plant sterols found to be effective in Type 2 diabetic patientsPlant sterols found to be effective in Type 2 diabetic patients
Plant chemicals called sterols might help to lower your bad LDL cholesterol according to a new study. Plant sterols have been shown to
http://www.medindia.net/news/view_news_main.asp?x=3966
Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemiaContent of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia
Abstract: Contents of scvalene, sterols and their derivatives were studied in lymphoid tissues as well as in liver and kidney tissues of normal rats and the animals with Shvetz experimental leukosis. Amount of cholesterol and of its precursor scvalene was distinctly decreased simultaneously with an increase in total content of nonsaponified substances in thymus, spleen, bone marrow and liver tissue of rats with experimental leukosis. Scvalene was increased in kidney tissue. Simultaneous accumulation of hydroxycholesterol derivatives, among which 7-beta-hydroxycholesterol was identified, was observed in these tissues under conditions of leukosis. Role of cholesterol hydroxyderivatives in biosynthesis of sterols is discussed ...
http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1983-29-3-64-en
Natural Sterol Complex Archives - Muscle and BrawnNatural Sterol Complex Archives - Muscle and Brawn
Oral and injectable steroids are derivatives of testosterone, a highly anabolic hormone. Historically, these anabolic steroids were synthesized from natural plant sterols (plant sterols share many chemical similarities). As steroids… Read more. ...
http://muscleandbrawn.com/tag/natural-sterol-complex/
Moducare® by Moducare (Plant Sterols Supplements) - ProHealth.comModucare® by Moducare (Plant Sterols Supplements) - ProHealth.com
Moducare is a pine extract that contains sterols, naturally occurring compounds found in all plants. Sterols have been shown to enhance immune function and support the bodys inflammation response.
https://www.prohealth.com/shop/product.cfm?product__code=N0102&B2=PRDDYNSID&utm_source=dynamicProducts&utm_medium=PRDDYNSID&utm_campaign=PRDDYNSID
Universal - Natural Sterol Complex - 90 caps - Universal - Natural Sterol Complex - 90 capsUniversal - Natural Sterol Complex - 90 caps - Universal - Natural Sterol Complex - 90 caps
Oferta la Universal - Natural Sterol Complex - 90 caps .Comanda si beneficiezi de un super pret si transport in 24h. Verifica si restul promotiilor la Universal Nutrition sau Performanta
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UNIVERSAL NATURAL STEROL COMPLEX 180 tab. bez príchute - Katalóg fitness doplnkov výživyUNIVERSAL NATURAL STEROL COMPLEX 180 tab. bez príchute - Katalóg fitness doplnkov výživy
Natural Sterol Complex - anabolický doplnok na báze prírodných sterolov Natural Sterol Complex je zdrojom prírodných sterolov a celého spektra výťažkov
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Sterols Plus Hx® - Independent Research StudiesSterols Plus Hx® - Independent Research Studies
InVite Health has conducted 10 independent research studies about Sterols Hx®. Read more about the effects that Sterols Hx® has on the body today.
https://www.invitehealth.com/independent-research-sterols-plus-hx.html
Abstract 87: Sterol-Mediated Regulation of γδ T Lymphocytes | Arteriosclerosis, Thrombosis, and Vascular BiologyAbstract 87: Sterol-Mediated Regulation of γδ T Lymphocytes | Arteriosclerosis, Thrombosis, and Vascular Biology
Objective: gammadelta (γδ) T lymphocytes, which bridge innate and adaptive immunity, may be differentially regulated by cholesterol and play distinct roles from the conventional alphabeta (αβ) subset in the development of atherosclerosis. γδ T cells represent a small subset of total T cells (∼ 3-5% of CD3+ cells). These cells express unique γδ T cell receptors, and recognize lipid and peptide antigens without processing and presentation by MHC molecules. γδ T cells react much faster toward pathogen invasion than αβ T cells, and thus are considered one of the first lines of immune defense.. Methods: αβ and γδ T lymphocytes from mice were evaluated for their lipid content, gene expression, proliferation, apoptosis, and activation.. Results and conclusion: Nile Red staining revealed higher intracellular lipid content in γδ T cells, comparing to the αβ subset (1.3 folds of αβ, p,0.05; n=5). We therefore hypothesize that the basal higher sterol content elicits the turnover and ...
http://atvb.ahajournals.org/content/32/Suppl_1/A87
Statement on sterols - Harvard HealthStatement on sterols - Harvard Health
The American Heart Associations science advisory on plant sterols and stanols offers good background information on their connection with cholesterol.
https://www.health.harvard.edu/newsletter_article/statement_on_sterols
CYP27A1 - Sterol 26-hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP27A1 gene & proteinCYP27A1 - Sterol 26-hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP27A1 gene & protein
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
http://www.uniprot.org/uniprot/Q02318
Sterol sidechain modificationSterol sidechain modification
When cursor points to a box further details will be displayed in a tooltip window. If you click on the box it will change to the appropriate reaction scheme or enzyme specification.. Part of cholesterol and related sterol biosynthesis. ...
https://www.enzyme-database.org/reaction/terp/sidechain.html
NSP Sterol-11+ Glandulars - NSP NutritionNSP Sterol-11+ Glandulars - NSP Nutrition
A multitude of plant and pharmaceutical glandulars to promote greater muscle mass, thickness and density with NO body fat addition.. NSP Sterol-11 Plus Glandulars is manufactured from the highest grade raw materials available for optimum results. The benefits of glandular substances have long been known for their sterol effects on growth and muscularity.. This product is not intended to diagnose, treat, cure, or prevent any disease. Recommended Use: Take 3-6 tablets throughout the day with meals. Keep in a cool dry place. Keep out of reach of children. You have my personal guarantee this product does not contain anything artificial. All natural ingredients.. ...
http://nsp-nutrition.com/product/nsp-sterol-11-glandulars/
sterols and stanols suppliers Manufacturers and Suppliers - Factory Price - Vita-Solarsterols and stanols suppliers Manufacturers and Suppliers - Factory Price - Vita-Solar
Are you looking for sterols and stanols suppliers? As one of the professional and experienced such exporters and wholesalers in China, Vita-Solar must be your best choice. Under strict quality control and management system, all of our products are made through regulatory process by using advanced equipment.
http://www.vsr-healthcare.com/product/sterols-and-stanols-suppliers.htm
sterols and stanols Manufacturers and Suppliers - Factory Price - Vita-Solarsterols and stanols Manufacturers and Suppliers - Factory Price - Vita-Solar
Are you looking for sterols and stanols? As one of the professional and experienced such exporters and wholesalers in China, Vita-Solar must be your best choice. Under strict quality control and management system, all of our products are made through regulatory process by using advanced equipment.
http://www.vsr-healthcare.com/product/sterols-and-stanols.htm
Natur-Leaf Sterols & Sterolins - 400 mgNatur-Leaf Sterols & Sterolins - 400 mg
Try Natur-Leaf, a unique natural dietary supplement, which supports the immune system by providing vital essential plant fats (sterols and sterolins, including beta-sitosterol), lacking in todays diets.
https://www.evenbetternow.com/proddetail.php?prod=Natur-Leaf_Sterols_Sterolins&cat=159
Natur-Leaf Sterols & Sterolins - 400 mgNatur-Leaf Sterols & Sterolins - 400 mg
Try Natur-Leaf, a unique natural dietary supplement, which supports the immune system by providing vital essential plant fats (sterols and sterolins, including beta-sitosterol), lacking in todays diets.
https://www.evenbetternow.com/proddetail.php?prod=Natur-Leaf_Sterols_Sterolins&cat=157
Sterols Summary Report | CureHunterSterols Summary Report | CureHunter
Sterols: Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
http://www.curehunter.com/public/keywordSummaryD013261-Sterols.do
Patent US7977498 - Reduction of sterols and other compounds from oils - Google PatentsPatent US7977498 - Reduction of sterols and other compounds from oils - Google Patents
A process for the removal of sterols, specifically cholesterol, from a triglyceride oil, preferably a marine triglyceride oil, said process comprising contacting an oil with an absorbent, specifically TRIS YL™, clay or a mixture thereof, heating the mixture to 100 C. to 210 C., preferably 150 C. to 170 C., preferably for a time period of greater than one minute and optionally at a pressure less than 133 Pa, preferably less than 1.33 Pa.
http://www.google.com/patents/US7977498?dq=4,923,986
RESPONSES OF MICROORGANISMS TO STEROLS AND STEROIDS.<...RESPONSES OF MICROORGANISMS TO STEROLS AND STEROIDS.<...
TY - JOUR. T1 - RESPONSES OF MICROORGANISMS TO STEROLS AND STEROIDS.. AU - BUETOW, D. E.. AU - LEVEDAHL, B. H.. PY - 1964/1/1. Y1 - 1964/1/1. UR - http://www.scopus.com/inward/record.url?scp=0009928220&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0009928220&partnerID=8YFLogxK. U2 - 10.1146/annurev.mi.18.100164.001123. DO - 10.1146/annurev.mi.18.100164.001123. M3 - Review article. C2 - 14268854. AN - SCOPUS:0009928220. VL - 18. SP - 167. EP - 194. JO - Annual Review of Microbiology. JF - Annual Review of Microbiology. SN - 0066-4227. ER - ...
https://experts.illinois.edu/en/publications/responses-of-microorganisms-to-sterols-and-steroids
Association between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial...Association between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial...
Background: Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas (TX). However, the clinical expression is highly variable. TX are present in other metabolic diseases that associate increased sterol concentration. If non-cholesterol sterols are involved in the development of TX in FH has not been analyzed. Methods: Clinical and biochemical characteristics, non-cholesterol sterols concentrations and Aquilles tendon thickness were determined in subjects with genetic FH with (n = 63) and without (n = 40) TX. Student-t test o Mann-Whitney test were used accordingly. Categorical variables were compared using a Chi square test. ANOVA and Kruskal-Wallis tests were performed to multiple independent variables comparison. Post hoc adjusted comparisons were performed with Bonferroni correction when applicable. Correlations of parameters in selected groups were
https://zaguan.unizar.es/record/65253/files/?ln=en
4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress<...
TY - JOUR. T1 - 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. AU - Hughes, Adam L.. AU - Lee, Chih Yung S.. AU - Bien, Clara M.. AU - Espenshade, Peter J.. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2007/8/17. Y1 - 2007/8/17. N2 - In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply. Under low oxygen conditions, sterol synthesis is inhibited, and Sre1 cleavage is activated. However, the sterol signal for Sre1 activation is unknown. In this study, we characterized the sterol signal for Sre1 activation using a combination of Sre1 cleavage assays and gas chromatography sterol analysis. We find that Sre1 activation is regulated by levels of the 4-methyl sterols 24-methylene lanosterol and 4,4-dimethylfecosterol under conditions of low oxygen and cell stress. Both increases and decreases in the level of these ergosterol pathway ...
https://jhu.pure.elsevier.com/en/publications/4-methyl-sterols-regulate-fission-yeast-srebp-scap-under-low-oxyg-3
Investigation into sterol signalling in Arabidopsis - Durham e-ThesesInvestigation into sterol signalling in Arabidopsis - Durham e-Theses
The hydra sterol mutants (hydral and fk(^hyd2)) phenotypes are characterised by short thickened roots and a shoot consisting of a mass of indistinct leaves. At the cellular level, cell patterning is disorganised and cell shape irregular, hydra sterol mutants are not phenotypically rescued by application of extrogeneous sterols (Lindsey et al, 2003) and have auxin and ethylene signalling defects but no defects in biosynthesis (Souter et al., 2002).It is not known at the mechanistic level how the hydra phenotype is generated. The disruption in sterol biosynthesis and subsequent altered sterol profile may lead to a loss of sterol-based signals required for development (Schrick et al, 2000), or disruption of other hormone signalling pathways (Souter et al. 2002, 2004); or some other mechanism. To determine whether sterol biosynthesis is required in specific cell types, we expressed the wild type HYDRA1 and HYDRA2 genes respectively under tissue specific promoters in the relevant hydra backgrounds ...
http://etheses.dur.ac.uk/2076/
Sterol Analysis - Phytosterols in plant, Hormones - Cholesterol | Lipd AnalyticalSterol Analysis - Phytosterols in plant, Hormones - Cholesterol | Lipd Analytical
Sterols Analysis Sterols, or Steroidal Alcohols, are members of the steroid family of organic molecules. Theses compounds fulfill essential roles in eukaryotic cell membrane structure and dynamics, and as precursors to steroid hormones and fat-soluble vitamins. This class of organic molecules is further sub-divided into phytosterols (plant sterols), zoosterols (animal sterols)
http://lipidanalytical.com/services/sterols
Studies on sterol biosynthesis mutants of Arabidopsis - Durham e-ThesesStudies on sterol biosynthesis mutants of Arabidopsis - Durham e-Theses
This thesis examines the gene promoter activity and morphological characteristics of mutants of HYDRA 1 (HYD 1) and HYDRA2 I FACKEL (HYD2 I FK) (Mayer et al. 1991, Topping et al. 1997) from Arabidopsis. These loci are unique, and encode components of the sterol biosynthesis pathway (Schrick et al. 2000, Souter et at. 2002). Various patterning processes are disrupted in hydra mutants (Topping et at. 1997), and bulk sterol profiles are altered (Schrick et at. 2000, Souter et al. 2002). The mutants show heightened responses to auxin, and their phenotype is partly ameliorated by inhibition of ethylene signalling (Souter et al. 2002, 2004, He et al. 2003). Although much previous attention has been given to the analysis of their phenotype, the precise basis of the pleiotropic defects seen in the hydra mutants have not been attributed to any single phenomenon.This thesis examines the hydra mutants body patterning and morphology, and aims to test the hypothesis that hydra mutants are defective in ...
http://etheses.dur.ac.uk/2952/
An Investigational Drug Study to Lower Non-Cholesterol Sterol Levels Associated With Sitosterolemia (0653-062)(COMPLETED) -...An Investigational Drug Study to Lower Non-Cholesterol Sterol Levels Associated With Sitosterolemia (0653-062)(COMPLETED) -...
This is a 6-month study with patients who have the rare disease, sitosterolemia which may result in heart-related diseases. These patients have unusually high absorption of non-cholesterol sterols, resulting in heart-related diseases. This study investigates whether absorption of these non-cholesterols can be reduced in these patients ...
https://clinicaltrials.gov/ct2/show/NCT00092898?cond=%22sitosterolemia%22+OR+%22beta-sitosterolemia%22+OR+%22phytosterolaemia%22+OR+%22sitosterolaemia%22+OR+%22Mediterranean+stomatocytosis+macrothrombocytopenia%22&rank=6
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans<...
TY - JOUR. T1 - Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. AU - Chang, Yun C.. AU - Bien, Clara M.. AU - Lee, Hyeseung. AU - Espenshade, Peter J.. AU - Kwon-Chung, Kyung J.. PY - 2007/5/1. Y1 - 2007/5/1. N2 - Cryptococcus neoformans is an environmental pathogen requiring atmospheric levels of oxygen for optimal growth. Upon inhalation, C. neoformans disseminates to the brain and causes meningoencephalitis, but the mechanisms by which the pathogen adapts to the low-oxygen environment in the brain have not been investigated. We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway. Low oxygen decreased sterol synthesis in C. neoformans and triggered activation of membrane-bound Sre1p by the cleavage-activating protein, Scp1p. Microarray and Northern blot analysis demonstrated that under low oxygen, Sre1p activates genes required for ergosterol ...
https://www.scholars.northwestern.edu/en/publications/sre1p-a-regulator-of-oxygen-sensing-and-sterol-homeostasis-is-req
Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent...Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent...
Somatic Cell and Molecular Genetic Analysis of Various Chinese Hamster Ovary (CHO) Mutant Cells Defective in Sterol-dependent Regulation of Cholesterol Biosynthesis and LDL Receptor Expression A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy by Mazahir Tahir Hasan Dartmouth College and Dartmouth Medical school Hanover, New Hampshire April 1993 ...
https://libarchive.dartmouth.edu/cdm/compoundobject/collection/dcdis/id/298838/rec/18
Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent...Somatic cell and molecular genetic analysis of various Chinese hamster ovary (CHO) mutant cells defective in sterol-dependent...
Somatic Cell and Molecular Genetic Analysis of Various Chinese Hamster Ovary (CHO) Mutant Cells Defective in Sterol-dependent Regulation of Cholesterol Biosynthesis and LDL Receptor Expression A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy by Mazahir Tahir Hasan Dartmouth College and Dartmouth Medical school Hanover, New Hampshire April 1993 ...
https://libarchive.dartmouth.edu/cdm/compoundobject/collection/dcdis/id/298838/rec/22
Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in ratsEffects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats
Andriamiarina, R.; Laraki, L.; Pelletier, X.; Debry, G., 1989: Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats
https://eurekamag.com/research/001/820/001820215.php
Biofuels. Altered sterol composition renders yeast thermotolerant.Biofuels. Altered sterol composition renders yeast thermotolerant.
Caspeta L, Chen Y, Ghiaci P, Feizi A, Buskov S, Hallström BM, Petranovic D, Nielsen J Science 346 (6205) 75-78 [2014-10-03; online 2014-10-02] Ethanol production for use as a biofuel is mainly achieved through simultaneous saccharification and fermentation by yeast. Operating at ≥40°C would be beneficial in terms of increasing efficiency of the process and reducing costs, but yeast does not grow efficiently at those temperatures. We used adaptive laboratory evolution to select yeast strains with improved growth and ethanol production at ≥40°C. Sequencing of the whole genome, genome-wide gene expression, and metabolic-flux analyses revealed a change in sterol composition, from ergosterol to fecosterol, caused by mutations in the C-5 sterol desaturase gene, and increased expression of genes involved in sterol biosynthesis. Additionally, large chromosome III rearrangements and mutations in genes associated with DNA damage and respiration were found, but contributed less to the thermotolerant ...
https://publications.scilifelab.se/publication/e7fdd93b68014f678a50df6f5e15f1c8
New sterol esters from the flowers of Punica granatum Linn. -...New sterol esters from the flowers of Punica granatum Linn. -...
New sterol esters from the flowers of Punica granatum Linn.: Two new beta-sitosterol esters have been isolated from the flowers of Punica granatum Linn. (Punica
https://www.mysciencework.com/publication/show/new-sterol-esters-from-flowers-punica-granatum-linn-5c22221a
Selective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation - InfoscienceSelective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation - Infoscience
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
https://infoscience.epfl.ch/record/163615
Selective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation - InfoscienceSelective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach-Rate-Based Image Segmentation - Infoscience
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
https://infoscience.epfl.ch/record/163615?ln=fr
Delineating the Upc2A Regulon in Candida glabrata by Yu Li
Candida glabrata is the second most common cause of invasive candidiasis. Intrinsic resistance has greatly limited the utility of the triazole antifungal, fluconazole, in the treatment of invasive fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting UPC2A in C. glabrata greatly increases its susceptibility to fluconazole (FLU) in both FLU-susceptible and -resistant clinical isolates. Therefore, the Upc2A and its target genes represent a potential pathway for overcoming FLU resistance in C. glabrata. We aimed to delineate the Upc2A regulon to determine its target genes involved in FLU resistance. Transcriptome sequencing (RNA-seq) analysis was used to compare gene expression profiles of: a) wild-type (WT) strains with and without UPC2A under non-stressed conditions; b) those same strains treated with three sterol biosynthesis inhibitors (SBIs; FLU, terbinafine, fenpropimorph); and c) strains with an activating mutation (GOF) in UPC2A.
https://dc.uthsc.edu/dissertations/552/
Oxysterol-binding protein elisa and antibodyOxysterol-binding protein elisa and antibody
Shop Oxysterol-binding protein ELISA Kit, Recombinant Protein and Oxysterol-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=oxysterol-binding-protein
PLANT STEROLS 500 mg 60 VEGETABLE CAPSULES - The Health Shoppe
Bluebonnets Plant Sterols 500 mg Capsules contain non-genetically engineered plant sterols from soy. Plant sterols are plant compounds that are chemically similar to cholesterol. Products supplying at least 500 mg per serving of plant sterols, taken twice a day with meals, for a daily intake of 1000 mg as part of a di
https://thehealthshoppe.co/products/plant-sterols-500-mg-60-vegetable-capsules
Spread With Added Plant Sterols and Fish Oil Lowers Triglycerides and Bad Cholesterol | FDBusiness.comSpread With Added Plant Sterols and Fish Oil Lowers Triglycerides and Bad Cholesterol | FDBusiness.com
New research demonstrates that the consumption of a combination of low dose omega-3 and plant sterols can effectively reduce both LDL-cholesterol and triglyceride levels in men and women with high cholesterol levels. The research, recently published in the Journal of Nutrition, is the findings of a research group from Unilever Research and Development Vlaardingen (The Netherlands), Quadt Consultanc (The Netherlands), and Food Files (Sweden).. Plant sterols are known to lower low-density lipoprotein cholesterol (LDL-C) whereas high intakes of the omega-3 fish fatty acids EPA and DHA are known to lower triglycerides. Consumption of a combination of plant sterols and EPA+DHA could therefore address these two blood lipid risk factors simultaneously.. High circulating levels of triglycerides and LDL-C - the so-called bad cholesterol - have both been linked with greater risk for heart disease and strokes. And although these associations do not necessarily indicate that these factors cause ...
http://www.fdbusiness.com/spread-with-added-plant-sterols-and-fish-oil-lowers-triglycerides-and-bad-cholesterol/
plant sterols Archives - HeartMart
If you are looking for ways to lower your cholesterol levels, a compound found in fruits, vegetables, and nuts can help. Plant sterols help to lower the level of cholesterol that is absorbed by the lower digestive tract from the food we eat.. The recommended daily amount for plant sterol consumption is two grams per day. You can get them by eating more fruits and vegetables, but you would have to eat a large amount of them to do so. A better choice is to choose foods that have plant sterols added to them.. Look for this ingredient added to foods like milk products, orange juice, crackers and margarine. Since they dont change the flavor or texture of the foods they are added to, you can reap the health benefits without being concerned about giving up taste.. People who consume the recommended daily amount of plant sterols in their diet can lower their LDL cholesterol by up to 10 percent ...
http://www.heartmart.com/blog/tag/plant-sterols/
Molecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes | JGPMolecular Aspects of Polyene- and Sterol-Dependent Pore Formation in Thin Lipid Membranes | JGP
Amphotericin B modifies the permeability properties of thin lipid membranes formed from solutions containing sheep red cell phospholipids and cholesterol. At 10-6 M amphotericin B, the DC membrane resistance fell from ≈108 to ≈102 ohm-cm2, and the membranes became Cl--, rather than Na+-selective; the permeability coefficients for hydrophilic nonelectrolytes increased in inverse relationship to solute size, and the rate of water flow during osmosis increased 30-fold. These changes may be rationalized by assuming that the interaction of amphotericin B with membrane-bound sterol resulted in the formation of aqueous pores. N-acetylamphotericin B and the methyl ester of N-acetylamphotericin B, but not the smaller ring compounds, filipin, rimocidin, and PA-166, produced comparable permeability changes in identical membranes, and amphotericin B and its derivatives produced similar changes in the properties of membranes formed from phospholipid-free sterol solutions. However, amphotericin B did not ...
http://jgp.rupress.org/content/55/3/375
Lower Your Cholesterol With Plant Sterols, Pt 1 | The Dr. Oz ShowLower Your Cholesterol With Plant Sterols, Pt 1 | The Dr. Oz Show
Could this 10-cent supplement be the cholesterol solution youve been looking for? Find out if plant sterols are right for you! View Part 2 of Lower Your Cholesterol With Plant Sterols. Read more about plant sterols.  Watch Dr. Oz reveal more 10-cent health solutions.
http://www.doctoroz.com/videos/lower-your-cholesterol-plant-sterols-pt-1
Cholesterol Lowering Plant Sterol Gummies from Piper BiosciencesCholesterol Lowering Plant Sterol Gummies from Piper Biosciences
Piper Biosciences plant sterol gummies are a delicious way to lower cholesterol*. Plant sterols are a physician recommended ingredient to reduce cholesterol. Our product is vegan and made from non-GMO plant sterols. Get started today!
https://www.piperbio.com/collections/cholesterol-wellness-kit/products/clinical-strength
100%natural 500g pygeum africanum extract 2 5% total sterols free shipping, цена - купить в Center-Broni
Продвинутые пользователи покупают 100%natural 500g pygeum africanum extract 2 5% total sterols free shipping с помощью сайта Center-Broni! Тут все цены интернета и отзывы по 100%natural 500g pygeum africanum extract 2 5% total sterols free shipping и прочим товарам.
http://center-broni.ru/100%25natural-500g-pygeum-africanum-extract-2-5%25-total-sterols-free-shipping/
Sterol affinity for bilayer membranes is affected by their ceramide content and the ceramide chain length. - CONVERIS Research...Sterol affinity for bilayer membranes is affected by their ceramide content and the ceramide chain length. - CONVERIS Research...
It is known that ceramides can influence the lateral organization in biological membranes. In particular ceramides have been shown to alter the composition of cholesterol and sphingolipid enriched nanoscopic domains, by displacing cholesterol, and forming gel phase domains with sphingomyelin. Here we have investigated how the bilayer content of ceramides and their chain length influence sterol partitioning into the membranes. The effect of ceramides with saturated chains ranging from 4 to 24 carbons in length was investigated. In addition, unsaturated 18:1- and 24:1-ceramides were also examined. The sterol partitioning into bilayer membranes was studied by measuring the distribution of cholestatrienol, a fluorescent cholesterol analogue, between methyl-beta-cyclodextrin and large unilamellar vesicle with defined lipid composition. Up to 15 mol% ceramide was added to bilayers composed of DOPC:PSM:cholesterol (3:1:1), and the effect on sterol partitioning was measured. Both at 23 and 37 degrees C ...
http://research.abo.fi/converis/portal/Publication/30366495?auxfun=&lang=en_GB
Carbon and hydrogen isotopic compositions of sterols from riverine and marine sediments<...
TY - JOUR. T1 - Carbon and hydrogen isotopic compositions of sterols from riverine and marine sediments. AU - Chikaraishi, Yoshito. AU - Yamada, Yusuke. AU - Naraoka, Hiroshi. PY - 2005/1/1. Y1 - 2005/1/1. N2 - The sources (marine algae, terrestrial C3 and C4 plants) of sterols deposited to sediments along a riverine-marine transect from Ohtsuchi River in Iwate Prefecture, Japan, to the northwestern Pacific Ocean were estimated using carbon (δ13C) and hydrogen isotopic compositions (δD) in surface sediments. In marine sediments, algal sterols such as 24-methylcholesta-5,22-dien-3β-ol had δ13C values of -22.7 ± 0.4‰ and δD values of -292 ± 3‰. In contrast, sterols derived from multiple potential sources, such as 24-methylcholest-5-en-3β-ol and 24-ethylcholest-5-en-3β-ol, were gradually enriched in 13C from riverine (-30.7‰ and -30.5‰, respectively) to marine sediments (-22.3‰ and -24.4‰, respectively), but showed little variation in δD values (-262 ± 1‰). These isotopic ...
https://kyushu-u.pure.elsevier.com/en/publications/carbon-and-hydrogen-isotopic-compositions-of-sterols-from-riverin
Molecules | Free Full-Text | Mechanism-based Enzyme Inactivators of Phytosterol BiosynthesisMolecules | Free Full-Text | Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis
Current progress on the mechanism and substrate recognition by sterol methyl transferase (SMT), the role of mechanism-based inactivators, other inhibitors of SMT action to probe catalysis and phytosterol synthesis is reported. SMT is a membrane-bound enzyme which catalyzes the coupled C-methylation-deprotonation reaction of sterol acceptor molecules generating the 24-alkyl sterol side chains of fungal ergosterol and plant sitosterol. This C-methylation step can be rate-limiting in the post-lanosterol (fungal) or post-cycloartenol (plant) pathways. A series of sterol analogs designed to impair SMT activity irreversibly have provided deep insight into the C-methylation reaction and topography of the SMT active site and as reviewed provide leads for the development of antifungal agents.
http://www.mdpi.com/1420-3049/9/4/185
What are Plant Sterols? - Piper BiosciencesWhat are Plant Sterols? - Piper Biosciences
Derived from soy, plant sterols naturally block the bodys absorption of cholesterol, lowering total and LDL (bad) cholesterol without affecting HDL (good) cholesterol. According to the FDA, a daily intake of 800 mg of plant sterols may reduce the risk of heart disease. Learn more about plant sterols.
https://www.piperbio.com/pages/plant-sterols
Moducare Plant Sterols & Sterolins 90 veggie caps | Alternative Natural Health ProductsModucare Plant Sterols & Sterolins 90 veggie caps | Alternative Natural Health Products
Moducare Plant Sterols & Sterolins 90 veggie caps Moducare is a daily immune supplement that restores, strengthens and balances the immune system. Moducare is a patented blend of plant sterols and sterolins in a clinically proven ratio of 100:1.These nutrients are derived from a natural pine source.Moducare is the only clinically tested plant sterol/sterolin product […]
https://www.natural-alternative-products.co.uk/product/moducare-plant-sterols-sterolins-90-veggie-caps/
Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan...
In metazoans, lysosomes are characterized by a unique tubular morphology, acidic pH, and specific membrane protein (LAMP) and lipid (cholesterol) composition as well as a soluble protein (hydrolases) composition. Here we show that perturbation to the eye-color gene, light, results in impaired lysosomal acidification, sterol accumulation, altered endosomal morphology as well as compromised lysosomal degradation. We find that Drosophila homologue of Vps41, Light, regulates the fusion of a specific subset of biosynthetic carriers containing characteristic endolysosomal membrane proteins, LAMP1, V0-ATPase and the cholesterol transport protein, NPC1, with the endolysosomal system, and is then required for the morphological progression of the multivesicular endosome. Inhibition of Light results in accumulation of biosynthetic transport intermediates that contain these membrane cargoes, whereas under similar conditions, endosomal delivery of soluble hydrolases, previously shown to be mediated by Dor, ...
http://vivo.mblwhoilibrary.org/display/publication211013
ProductProduct
Oral and injectable steroids are derivatives of testosterone, a highly anabolic hormone. Historically, these anabolic steroids were synthesized from natural plant sterols (plant sterols share many chemical similarities). As steroids are illegal, require a prescription, and raise the risk of many unwanted side effects, many bodybuilders have long sought natural alternatives. This search led to the invention of the original Natural Sterol Complex more than a decade ago. Natural Sterol Complex, a plant sterol-based anabolic supplement, is the powerful but natural alternative that serious bodybuilders have been looking for. Eight distinct and potent components make up the best-selling Natural Sterol Complex formula: plant sterols, amino acids, energy substrates, essential fatty acids (EFAs), electrolytes, performance boosters, nucleosides, and important minerals. These components ensure that Natural Sterol Complex will get you bigger and harder in a shorter period of time. The select plant sterol ...
http://www.universalnutrition.com/store/html/product.cfm?id=91
Plant Sterols - AnabolicMinds.comPlant Sterols - AnabolicMinds.com
Ive read a few studies on the effectiveness of plant sterols for natural lifters. These plant sterols can target androgen receptors to build lean
http://anabolicminds.com/forum/supplements/295752-plant-sterols.html
Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature |...Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature |...
Regulated, stimulus-dependent secretion via the exocytosis of dense core granule content provides a mechanism for controlling delivery of hormones, enzymes, neuropeptides, and neurotransmitters to a target cell or organ in a timely and quantified manner (Burgoyne and Morgan, 2003; Loh et al., 2004; Lou et al., 2005). In this study, we have investigated the contributions of cholesterol, 7-DHC and lathosterol to granule biogenesis and regulated secretion in exocrine and endocrine tissues of mouse models of SLOS and lathosterolosis. We report here that cholesterol is necessary for the correct formation of granules in vivo. In the formation of regulated secretory vesicles in animals with inborn errors of cholesterol synthesis, cholesterol cannot be substituted by other lipids with structural similarity. We also show deregulated secretion of cargo in acinar cells of the exocrine pancreas, owing to the absence of cholesterol, which suggests impairment of cellular function.. It has been reported that ...
http://jcs.biologists.org/content/119/9/1876
Plus itPlus it
Endothelial cells in culture retain many of the functional properties of the endothelium in vivo. At high cell density, they become contact-inhibited. Endothelial cells, like vascular smooth muscle cells and fibroblasts, express binding sites for low density lipoprotein when depleted of sterol. In contact-inhibited endothelial cells (but not actively growing cells), a block to internalization is evident, so that the cells bind but do not interiorize low density lipoprotein. Lipoprotein sterol does not enter the cell or regulate endogenous sterol synthesis. On the other hand, both contact-inhibited and actively growing endothelial cells express a separate receptor for triglyceride-rich lipoproteins. Cholesterol in these lipoproteins, unlike that in LDL, effectively regulates sterol synthesis in contact-inhibited endothelial cells and also mediates the accumulation of cholesterol in these cells. These findings are related to current concepts of atherogenesis. Receptors for triglyceride-rich ...
http://diabetes.diabetesjournals.org/content/30/Supplement_2/19
ARV1 - Protein ARV1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - ARV1 gene & proteinARV1 - Protein ARV1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - ARV1 gene & protein
Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake.
http://www.uniprot.org/uniprot/Q06541
Benefits of Plant Sterols
Plant sterols appear to be beneficial for lowering cholesterol and reducing the risk of heart disease. This eMedTV segment discusses other potential benefits of plant sterols and explains how the natural compounds work for reducing cholesterol levels.
http://heart-disease.emedtv.com/plant-sterols/benefits-of-plant-sterols.html
PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus | AntibodyChainPAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus | AntibodyChain
Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi apparatus where SREBP is activated. Under cholesterol sufficient condition, Insigs act as anchor proteins to retain Scap/SREBP in the ER.
http://www.antibodychain.com/antibody_news/paqr3_modulates_cholesterol_homeostasis_anchoring_scapsrebp_complex_golgi_apparatus
plant sterols (part two)plant sterols (part two)
A few posts ago I compared a few products that include plant sterols to see which one was the better buy. Link During that post I mentioned how people looking for plant sterols now have some options on how they want to include it. How? If you look at the back of the Minute Maid orange…
https://cholesterblog.wordpress.com/2008/01/17/plant-sterols-part-two/
Plant sterol steroids | Sterol - Wikipedia
Plant sterols occur naturally in food and are similar in structure to cholesterol, the HDL fat that is abundant in animal sourced fats. But what is not generally known is that the body produces its own cholesterol which is secreted into the digestive
http://oiu.steroids-australia.net/plant-sterol-steroids.html
Sterol metabolism of micro-organisms | Biochemical JournalSterol metabolism of micro-organisms | Biochemical Journal
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemj.org/content/34/6/804
Stanols/Sterols | Doctors HospitalStanols/Sterols | Doctors Hospital
Learn more about Stanols/Sterols at Doctors Hospital of Augusta Supplement Forms/Alternate Names Phytostanols Sitostanol Campestanol Stigmastanol 5-Alpha-Stanols Stanol...
https://doctors-hospital.net/hl/?/21394/Phytostanols&com.dotmarketing.htmlpage.language=1
Comparison of Genes Encoding Enzymes of Sterol Biosynthesis from Plants to Orthologs in Yeast | OMICS InternationalComparison of Genes Encoding Enzymes of Sterol Biosynthesis from Plants to Orthologs in Yeast | OMICS International
3βHSD/D: 3β-hydroxysteroid-dehydrogenase/C4- decarboxylase; BRs: brassinosteroids; CAS: cycloartenol synthase; CPI: cyclopropyl sterol isomerase; cyt: cytochrom..
https://www.omicsonline.org/open-access/comparison-of-genes-encoding-enzymes-of-sterol-biosynthesis-fromplants-to-orthologs-in-yeast-2375-4338-1000160.php?aid=67583
GLYCINE SOJA (SOYBEAN) STEROLSGLYCINE SOJA (SOYBEAN) STEROLS
GLYCINE SOJA (SOYBEAN) STEROLS. Un sterol este un alcool complex solid derivat din animale si plante. Sterolii ajuta la refacerea functiei de bariera naturala a pielii deteriorate, imbunatatesc fluiditatea si rezistenta membranei, protejeaza impotriva iritantilor externi, mentin echilibrul de apa, reduc...
https://www.alegesanatos.ro/ingrediente/glycine-soja-soybean-sterols-2680/
Plant Sterol Pills Lower LDL -- MEDICA - World Forum for MedicinePlant Sterol Pills Lower LDL -- MEDICA - World Forum for Medicine
A pill containing plant substances called sterols can help lower cholesterol, according to researchers at Washington University School of Medicine in St. Louis.
https://www.medica-tradefair.com/cgi-bin/md_medica/lib/pub/tt.cgi/Plant_Sterol_Pills_Lower_LDL.html?oid=17979&lang=2&ticket=g_u_e_s_t
Stereochemistry of Hydrogen Addition to C-25 of Desmosterol by Sterol-Δ|sup|24|/sup|-Reductase of Rat Liver Homogenate -...
Fingerprint Dive into the research topics of Stereochemistry of Hydrogen Addition to C-25 of Desmosterol by Sterol-Δ,sup,24,/sup,-Reductase of Rat Liver Homogenate. Together they form a unique fingerprint. ...
https://keio.pure.elsevier.com/en/publications/stereochemistry-of-hydrogen-addition-to-c-25-of-desmosterol-by-st/fingerprints/
1zi7 » Oxysterol-binding protein homolog 4 (KES1), N-terminal helix removed - Orientations of Proteins in Membranes (OPM)...
Im YJ, Raychaudhuri S, Prinz WA, Hurley JH. 2005. Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature. 437:154-8. PubMed ...
http://opm.phar.umich.edu/protein.php?pdbid=1zi7
Get PDF - Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a...Get PDF - Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a...
Taton, M.; Benveniste, P.; Rahier, A., 1989: Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction
https://eurekamag.com/research/040/700/040700566.php
Plant Sterols Supplements Review - Top 10 Picks by Experts!Plant Sterols Supplements Review - Top 10 Picks by Experts!
Plant sterols supplements have been proven both effective and safe in terms of lowering cholesterol numbers. How do these cholesterol lowering remedies work
http://cholesterolnumbers.org/best-plant-sterols-supplements-review/
plant sterolsplant sterols
We were just provided our first tube of Policosanol. It claims to be superior to Plant Sterols and Stanols for cholesterol. Read more ...
http://www.chrisbyrnes.com/tag/plant-sterols/
Stigmasterol-rich plant sterolsStigmasterol-rich plant sterols
... is a food additive. It is a mixture derived from soybeans that consists of the plant sterols ... "Scientific Opinion on the safety of stigmasterol-rich plant sterols as food additive". EFSA Journal. 10 (5): 2659. doi:10.2903/ ...
https://en.wikipedia.org/wiki/Stigmasterol-rich_plant_sterols
SterolSterol
While technically alcohols, sterols are classified by biochemists as lipids (fats in the broader sense of the term). Sterols of ... Sterols are common components of human skin oils. Phytosterols, more commonly known as plant sterols, have been shown in ... Sterol is an organic compound with formula C 17H 28O, whose molecule is derived from that of gonane by replacement of a ... Ergosterol is a sterol present in the cell membrane of fungi, where it serves a role similar to cholesterol in animal cells. ...
https://en.wikipedia.org/wiki/Sterol
Sterol esteraseSterol esterase
The enzyme sterol esterase (EC 3.1.1.13) catalyzes the reaction a sterol ester + H2O ⇌ {\displaystyle \rightleftharpoons } a ... Okawa Y, Yamaguchi T (May 1977). "Studies on sterol-ester hydrolase from Fusarium oxysporum. I Partial purification and ... sterol ester hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile ... sterol + a fatty acid This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The ...
https://en.wikipedia.org/wiki/Sterol_esterase
Sterol esterSterol ester
... s are a heterogeneous group of chemical compounds. They are created when the hydroxyl group of a sterol and a fatty ... Plant sterol esters have been shown to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested. ... Plant sterol esters used for dietary supplements are made from phytosterols and fatty acids also derived from plants. They are ... Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R (2003). "Efficacy and safety of plant stanols and sterols in the ...
https://en.wikipedia.org/wiki/Sterol_ester
Sterol O-acyltransferaseSterol O-acyltransferase
Sterol Acyltransferase (PSAT). A recent study shows that PSAT is involved in the regulation of the pool of free sterols and the ... "Cellular sterol ester synthesis in plants is performed by an enzyme (phospholipid:sterol acyltransferase) different from the ... In plants cellular sterol ester synthesis is performed by an enzyme different from mammalian ACAT and yeast ASAT; it is ... Acyl-CoA cholesterol acyl transferase EC 2.3.1.26, more simply referred to as ACAT, also known as sterol O-acyltransferase ( ...
https://en.wikipedia.org/wiki/Sterol_O-acyltransferase
Sterol-sensing domainSterol-sensing domain
... which regulates transcription of genes with sterol response elements by proteolytically activating sterol regulatory element- ... A sterol-sensing domain (SSD) is a protein domain which consists of 180 amino acids forming five transmembrane segments capable ... Sterol-sensing domains are present in various proteins involved in key aspects of cholesterol homeostasis and signalling. ... Kuwabara, PE; Labouesse, M (April 2002). "The sterol-sensing domain: multiple families, a unique role?". Trends in Genetics. 18 ...
https://en.wikipedia.org/wiki/Sterol-sensing_domain
Sterol 14-demethylaseSterol 14-demethylase
... and other types of sterols in plants. These sterols localize to the plasma membrane of cells, where they play an important ... In enzymology, a sterol 14-demethylase (EC 1.14.13.70) is an enzyme of the Cytochrome P450 (CYP) superfamily. It is any member ... The systematic name of this enzyme class is sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving). Other names in common use ... Becher R, Wirsel SG (August 2012). "Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and ...
https://en.wikipedia.org/wiki/Sterol_14-demethylase
Delta14-sterol reductaseDelta14-sterol reductase
In enzymology, a Delta14-sterol reductase (EC 1.3.1.70) is an enzyme that catalyzes the chemical reaction 4,4-dimethyl-5alpha- ... Bottema CK, Parks LW (1978). "Delta14-sterol reductase in Saccharomyces cerevisiae". Biochim. Biophys. Acta. 531 (3): 301-7. ...
https://en.wikipedia.org/wiki/Delta14-sterol_reductase
Sterol 3beta-glucosyltransferaseSterol 3beta-glucosyltransferase
Other names in common use include UDPG:sterol glucosyltransferase, UDP-glucose-sterol beta-glucosyltransferase, sterol:UDPG ... sterol glucosyltransferase, sterol-beta-D-glucosyltransferase, and UDP-glucose-sterol glucosyltransferase. Duperon R; Duperon P ... a sterol 3-beta-D-glucoside Thus, the two substrates of this enzyme are UDP-glucose and sterol, whereas its two products are ... 1987). "Intracellular-localization of UDP-glucose-sterol glucosyl transferase and UDP-galactose-sterol galactosyl transferase ...
https://en.wikipedia.org/wiki/Sterol_3beta-glucosyltransferase
Sterol 12alpha-hydroxylaseSterol 12alpha-hydroxylase
... may refer to: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase, an enzyme 7alpha- ...
https://en.wikipedia.org/wiki/Sterol_12alpha-hydroxylase
Delta24-sterol reductaseDelta24-sterol reductase
In enzymology, a Delta24-sterol reductase (EC 1.3.1.72) is an enzyme that catalyzes the chemical reaction 5alpha-cholest-7-en- ... The systematic name of this enzyme class is sterol:NADP+ Delta24-oxidoreductase. This enzyme is also called lanosterol Delta24- ...
https://en.wikipedia.org/wiki/Delta24-sterol_reductase
Sterol carrier proteinSterol carrier protein
... s in SCOP SCP-2 sterol transfer family in Pfam UMich Orientation of Proteins in Membranes families/ ... This domain is involved in binding sterols. The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to ... Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and ... superfamily-144 sterol+carrier+proteins at the US National Library of Medicine Medical Subject Headings (MeSH) This article ...
https://en.wikipedia.org/wiki/Sterol_carrier_protein
Sterol-C5-desaturase-likeSterol-C5-desaturase-like
"Entrez Gene: SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like". Shefer S, Salen G, Batta AK, et ... Lathosterol oxidase is a Delta7-sterol 5(6)-desaturase enzyme that in humans is encoded by the SC5D gene. This gene encodes an ... Nishi S, Nishino H, Ishibashi T (2000). "cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant ... Sugawara T, Fujimoto Y, Ishibashi T (2001). "Molecular cloning and structural analysis of human sterol C5 desaturase". Biochim ...
https://en.wikipedia.org/wiki/Sterol-C5-desaturase-like
Triacylglycerol-sterol O-acyltransferaseTriacylglycerol-sterol O-acyltransferase
This enzyme is also called triacylglycerol:sterol acyltransferase. Zimowski J, Wojciechowski ZA (1981). "Acyl donors for sterol ... In enzymology, a triacylglycerol---sterol O-acyltransferase (EC 2.3.1.77) is an enzyme that catalyzes the chemical reaction ...
https://en.wikipedia.org/wiki/Triacylglycerol—sterol_O-acyltransferase
Delta24(241)-sterol reductaseDelta24(241)-sterol reductase
Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme ... In enzymology, a Delta24(241)-sterol reductase (EC 1.3.1.71) is an enzyme that catalyzes the chemical reaction ergosterol + ... Zweytick D, Hrastnik C, Kohlwein SD, Daum G (2000). "Biochemical characterization and subcellular localization of the sterol C- ... Neal WD, Parks LW (1977). "Sterol 24(28) methylene reductase in Saccharomyces cerevisiae". J. Bacteriol. 129 (3): 1375-8. PMC ...
https://en.wikipedia.org/wiki/Delta24(241)-sterol_reductase
C-5 sterol desaturaseC-5 sterol desaturase
Delta 7-Sterol-C5-desaturase (STE1/DWARF7), Delta 5, 7-sterol-Delta 7-reductase (DWARF5) and Delta 24-sterol-Delta 24-reductase ... C-5 sterol desaturase (also known as sterol C-5 desaturase and C5SD) is an enzyme that is highly conserved among eukaryotes and ... C-5 sterol desaturase couples sterol oxidation to the oxidation of NAD(P)H and the reduction of molecular oxygen. Either NADH ... C-5 sterol desaturase catalyzes an intermediate step in the synthesis of major sterols. The particular biosynthetic pathway ...
https://en.wikipedia.org/wiki/C-5_sterol_desaturase
Sterol 24-C-methyltransferaseSterol 24-C-methyltransferase
... sterol Delta24-methyltransferase, SMT1, 24-sterol C-methyltransferase, S-adenosyl-L-methionine:Delta24(23)-sterol ... "Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol ... In enzymology, a sterol 24-C-methyltransferase (EC 2.1.1.41) is an enzyme that catalyzes the chemical reaction S-adenosyl-L- ... Moore JT, Gaylor JL (1969). "Isolation and purification of an S-adenosylmethionine: delta 24-sterol methyltransferase from ...
https://en.wikipedia.org/wiki/Sterol_24-C-methyltransferase
Diacylglycerol-sterol O-acyltransferaseDiacylglycerol-sterol O-acyltransferase
... sterol ester Thus, the two substrates of this enzyme are 1,2-diacyl-sn-glycerol and sterol, whereas its two products are ... The systematic name of this enzyme class is 1,2-diacyl-sn-glycerol:sterol O-acyltransferase. This enzyme is also called 1,2- ... In enzymology, a diacylglycerol-sterol O-acyltransferase (EC 2.3.1.73) is an enzyme that catalyzes the chemical reaction 1,2- ... Garcia RE; Mudd JB (1981). "1,2-Diacyl-sn-glycerol:sterol acyl transferase from spinach leaves (Spinacia oleracea L.)". Methods ...
https://en.wikipedia.org/wiki/Diacylglycerol—sterol_O-acyltransferase
Phosphatidylcholine-sterol O-acyltransferasePhosphatidylcholine-sterol O-acyltransferase
... a sterol ester Thus, the two substrates of this enzyme are phosphatidylcholine and sterol, whereas its two products are 1- ... The systematic name of this enzyme class is phosphatidylcholine:sterol O-acyltransferase. Other names in common use include ... In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction ... Bartlett K, Keat MJ, Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry. 13: 1107- ...
https://en.wikipedia.org/wiki/Phosphatidylcholine—sterol_O-acyltransferase
Δ7-sterol 5(6)-desaturaseΔ7-sterol 5(6)-desaturase
Other names in common use include: lathosterol oxidase Δ7-sterol Δ5-dehydrogenase Δ7-sterol 5-desaturase Δ7-sterol-C5(6)- ... Its three products are Δ5,7-sterol, ferricytochrome b5, and H2O. This enzyme is one of C-5 sterol desaturases, belongs to the ... In enzymology, a Δ7-sterol 5(6)-desaturase (EC 1.14.19.20) is an enzyme that catalyzes the chemical reaction Δ7-sterol + 2 ... Taton M, Rahier A (1996). "Plant sterol biosynthesis: identification and characterization of higher plant Δ7-sterol C5(6)- ...
https://en.wikipedia.org/wiki/Δ7-sterol_5(6)-desaturase
Sterol regulatory element-binding proteinSterol regulatory element-binding protein
Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed ... Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ... When sterol levels are low, INSIG and SCAP no longer bind. Then, SCAP undergoes a conformational change that exposes a portion ... In the presence of sterols, which bind to INSIG and SCAP, INSIG and SCAP also bind one another. INSIG always stays in the ER ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein
Sterol regulatory element-binding protein 1Sterol regulatory element-binding protein 1
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 ( ... Ericsson J, Edwards PA (Jul 1998). "CBP is required for sterol-regulated and sterol regulatory element-binding protein- ... "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1". Eberlé D, Hegarty B, Bossard P, Ferré P, ... Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_1
Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) is an enzyme that catalyzes the ... Brady DR, Crowder RD, Hayes WJ (1980). "Mixed function oxidases in sterol metabolism. Source of reducing equivalents". J. Biol ... Rahimtula AD, Gaylor JL (1972). "Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase". J. Biol. Chem. ... and sterol 4alpha-carboxylic decarboxylase. This enzyme participates in biosynthesis of steroids. ...
https://en.wikipedia.org/wiki/Sterol-4alpha-carboxylate_3-dehydrogenase_(decarboxylating)
Sterol regulatory element-binding protein 2Sterol regulatory element-binding protein 2
... (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... Sato R, Inoue J, Kawabe Y, Kodama T, Takano T, Maeda M (Oct 1996). "Sterol-dependent transcriptional regulation of sterol ... "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element- ... "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2". Qiu XM, Jin CT, Wang W (Apr 2014). "Association ...
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_2
Marker degradationMarker degradation
Marker, Russell E.; Rohrmann, Ewald (1939), "Sterols. LIII. The Structure of the Side Chain of Sarsasapogenin", J. Am. Chem. ... Marker, Russell E.; Tsukamoto, Takeo; Turner, D. L. (1940), "Sterols. C. Diosgenin", J. Am. Chem. Soc., 62 (9): 2525-32, doi: ... 281-83, ISBN 978-0-470-74167-2. Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and ... Marker, Russell E.; Rohrmann, Ewald (1939), "Sterols. LXXXI. Conversion of Sarsasapogenin to Pregnanediol-3(α),20(α)", J. Am. ...
https://en.wikipedia.org/wiki/Marker_degradation
DiosgeninDiosgenin
"2950 Diosgenin". Retrieved 2007-05-29.[permanent dead link] Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The ...
https://en.wikipedia.org/wiki/Diosgenin
Yam (vegetable)Yam (vegetable)
Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone". ...
https://en.wikipedia.org/wiki/Yam_(vegetable)
SteroidSteroid
Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholestane.: 1785f Steroids ... Schroepfer GJ (1981). "Sterol biosynthesis". Annual Review of Biochemistry. 50: 585-621. doi:10.1146/annurev.bi.50.070181. ... ISBN 978-1-4020-9774-4. Conner AH, Nagaoka M, Rowe JW, Perlman D (August 1976). "Microbial conversion of tall oil sterols to ... Desmond E, Gribaldo S (2009). "Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key ...
https://en.wikipedia.org/wiki/Steroid
ProgesteroneProgesterone
Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone". J ...
https://en.wikipedia.org/wiki/Progesterone
16-Dehydropregnenolone acetate16-Dehydropregnenolone acetate
Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone". J ...
https://en.wikipedia.org/wiki/16-Dehydropregnenolone_acetate
Corazonas claims first with sterol-containing chipsCorazonas claims first with sterol-containing chips
Functional snack company Corazonas is launching potato chips containing plant sterols for cholesterol reduction, and claims to ... Corazonas claims first with sterol-containing chips. By Jess Halliday 04-Jan-2008. - Last updated on 19-Jul-2008 at 21:49. GMT ... Plant sterols have most commonly been used in dairy products, such as yoghurt shots, margarine spreads, and juice drinks. Last ... containing plant sterols for cholesterol reduction, and claims to be the first manufacturer to take the healthy ingredient into ...
https://www.nutraingredients-usa.com/Article/2008/01/04/Corazonas-claims-first-with-sterol-containing-chips
Sterols and Stanols: What to KnowSterols and Stanols: What to Know
What are sterols and stanols, and how can they lower your cholesterol? Find out what foods theyre in and who can benefit most ... Sterols and stanols also come as dietary supplements. Though taking supplements is better than getting no sterols or stanols in ... How to Get Sterols and Stanols. According to the National Cholesterol Education Program, you need 2 grams of plant sterols and ... Sterols, Stanols, and Cholesterol. Cholesterol is a waxy substance that your liver makes. It protects nerves and makes cell ...
https://www.webmd.com/cholesterol-management/sterols-stanols-what-know?page=2
STEROLS AND STANOLS STAND TOUGHSTEROLS AND STANOLS STAND TOUGH
... Fruits and vegetables contain health-promoting compounds called phytosterols, specifically ... 1. Law M. Plant sterol and stanol margarines and health. BMJ 2000;320:861-4. 2. Vanhanen HT, et al. Serum cholesterol, ... In results of a recent meta-analysis, plant sterols and stanols lowered LDL cholesterol concentrations in a dose-dependent way ... and cholesterol including two servings of foods containing plant sterol or stanol esters supplying at least 1.3 plant sterols ...
https://chiro.org/Graphics_Box_NUTRITION/FULL/Sterols_And_Stanols_Stand_Tough.html
Sterol - WikipediaSterol - Wikipedia
Sterols of plants are called phytosterols and sterols of animals are called zoosterols. The most important zoosterol is ... Sterol is an organic compound with formula C. 17H. 28O, whose molecule is derived from that of gonane by replacement of a ... Sterols are a subgroup of steroids with a hydroxyl group at the 3-position of the A-ring.[7] They are amphipathic lipids ... "Do we need to be buying plant sterols?" (PDF). Food Magazine. 67: 14. October-December 2004. Archived from the original (PDF) ...
https://en.m.wikipedia.org/wiki/Sterol
Sterols | Semantic ScholarSterols | Semantic Scholar
Sterols. Known as: Sterols [Chemical/Ingredient], sterol Steroids with a hydroxyl group at C-3 and most of the skeleton of ... Sterol-balance studies were performed in 10 control subjects, 10 normolipidemic obese patients, and 10 hypertriglyceridemic ( ... Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals ... Effects of a plant sterol-enriched spread on serum lipids and lipoproteins in mildly hypercholesterolaemic subjects ...
https://www.semanticscholar.org/topic/Sterols/1778
Hypothesis: The Role of Sterols in Autism Spectrum DisorderHypothesis: The Role of Sterols in Autism Spectrum Disorder
This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog ... Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by ... but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal ... A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, ...
https://www.hindawi.com/journals/aurt/2011/653570/
Plant Sterols Archives - Better NutritionPlant Sterols Archives - Better Nutrition
Plant Sterols. <. >", "path": "https://www.betternutrition.com/conditions-and-wellness/immunity-tips/nutrients-herbs-fight-off- ...
https://www.betternutrition.com/tag/plant-sterols/
SterolsSterols
Headquarters , 2550 Acton Rd Birmingham, AL 35243 (205) 663-2494 (800) 227-0651 Contact us Production Facility , 700 Industrial Park Drive Alabaster, Alabama 35007-9105 ...
https://avantilipids.com/product-category/lipidomics/lipid-maps-ms-standards/core-j-sterols-lipid-maps-ms-standards
EWGs Guide to Healthy Cleaning | PEG-25 SOY STEROL | SubstanceEWG's Guide to Healthy Cleaning | PEG-25 SOY STEROL | Substance
PEG-25 SOY STEROL. Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation.. ...
https://www.ewg.org/guides/substances/4175-PEG25SOYSTEROL/
Sterols play major role in dietary portfolio for heartsSterols play major role in dietary portfolio for hearts
Almost one-third of cholesterol reductions achieved by consuming a heart-healthy diet are due to plant sterols, suggests a new ... and 10.3 per cent in the absence of sterols. The results showed, state Jenkins and co-workers, that plant sterols contribute ... "Increased plant sterol intakes are likely to have been a part of the ancestral human diet at about one gram per day and are ... In addition, plant sterols were taken (one gram per 1,000 kcal), except during weeks 52 to 62. Over the course of the study, ...
https://www.nutraingredients.com/Article/2008/02/12/Sterols-play-major-role-in-dietary-portfolio-for-hearts
sterol esterase activity | SGDsterol esterase activity | SGD
Gene Ontology Term: sterol esterase activity. GO ID. GO:0004771 Aspect. Molecular Function. Description. Catalysis of the ... sterol ester hydrolase activity, steryl-ester acylhydrolase activity, triterpenol esterase activity View GO Annotations in ... sterol ester hydrolase activity, steryl-ester acylhydrolase activity, triterpenol esterase activity, acylcholesterol lipase ... reaction: a steryl ester + H2O = a sterol + a fatty acid.. Synonyms. acylcholesterol lipase activity, cholesterase activity, ...
https://www.yeastgenome.org/go/GO:0004771
STEROL • FREE-TRANSLATOR.COM • Definition of SterolSTEROL • FREE-TRANSLATOR.COM • Definition of Sterol
Definition of Sterol at Free-Translator.com ...
http://www.free-translator.com/english/sterol.html
Sterols Market Size, Share & Growth Factors | Forecast - 2027Sterols Market Size, Share & Growth Factors | Forecast - 2027
The Sterols Market research report presents information related to key drivers, restraints, and opportunities along with a ... Questions answered in the global sterols market research report:. *Which are the leading players active in the global sterols ... Leading market players have developed new and advanced uses of sterols in the beauty & personal care industry. Sterols are used ... which have increased the demand for sterols in the health food segment. In addition, sterols are used by the dairy industry for ...
https://www.alliedmarketresearch.com/sterols-market-A10003
NY N010609 - The tariff classification of plant sterol products from Germany. - United States International Trade Commision...NY N010609 - The tariff classification of plant sterol products from Germany. - United States International Trade Commision...
The laboratory found the sample of CardioAid Plant Sterols to be composed of 100 percent plant sterols. CardioAid Plant Sterols ... RE: The tariff classification of plant sterol products from Germany.. Dear Ms. Huffines:. In your letters dated February 27, ... The sample, CardioAid Plant Sterols, was forwarded to the Customs and Border Protection laboratory for analysis. All the ...
http://www.faqs.org/rulings/rulings2007NYN010609.html
Plant Sterol Esters Market share - Express Press Release DistributionPlant Sterol Esters Market share - Express Press Release Distribution
Introduction Sterol ester is created when sterol and a fatty acid are synthesised (esterification). Sterol Esters [read full ... Introduction Sterol ester is created when sterol and a fatty acid are synthesised (esterification). Sterol Esters [read full ... Plant Sterol Esters Market share. Plant Sterol Esters Market Overview, Trends, Growth, Demand, Key Players Analysis and ... Plant Sterol Esters Market Key Facts, Market Size, Dynamics, Segments and Forecast Predictions Presented and Forecast: 2022- ...
https://express-press-release.net/news/press-releases-tagged-with/plant-sterol-esters-market-share
Phosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard CatalystPhosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard Catalyst
Phosphatidylcholine-Sterol O-Acyltransferase*Phosphatidylcholine-Sterol O-Acyltransferase. *O-Acyltransferase, ... "Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicines controlled vocabulary ... This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in ... Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles. ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Phosphatidylcholine-Sterol%20O-Acyltransferase
Universal Nutrition Natural Sterol Complex - Ill Pump You UpUniversal Nutrition Natural Sterol Complex - I'll Pump You Up
Universal Nutrition Natural Sterol Complex has been the bodybuilders solution for decades! This powerful formula contains ... Universal Nutrition Natural Sterol Complex. $19.99. - $27.99. Universal Nutrition Natural Sterol Complex has been the ... Natural Sterol Complex supports size, density, performance and recovery. You can use it as a stand-alone product or stack it ... The legendary Natural Sterol Complex by Universal Nutrition is the natural solution that serious bodybuilders have been waiting ...
https://illpumpyouup.com/universal-nutrition-natural-sterol-complex/
Human Metabolome Database: HMDB0060512 (Sterol) Protein AssociationsHuman Metabolome Database: HMDB0060512 (Sterol) Protein Associations
This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...
https://hmdb.ca/metabolites/HMDB0060512/metabolite_protein_links
SMART: Pfam domain Sterol-sensingSMART: Pfam domain Sterol-sensing
Sterol-sensing. PFAM accession number:. PF12349. Interpro abstract (IPR000731):. The sterol-sensing domain (SSD) is an around ... It is not known whether it interacts with sterols, such as cholesterol, or whether it interacts with another-sterol regulated ... The domain within your query sequence starts at position 396 and ends at position 550; the E-value for the Sterol-sensing ... The SSD domain is conserved across phyla and confers sensitivity to regulation by sterol. Although the SSD domain appears to ...
https://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:Sterol-sensing&START=396&END=550&E_VALUE=7.9e-47&TYPE=PFAM&BLAST=CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS
Plant sterol enriched margarines increase cardiovascular risk? - BMJ Case Reports blogPlant sterol enriched margarines increase cardiovascular risk? - BMJ Case Reports blog
Plant sterol enriched margarines increase cardiovascular risk?. Posted on August 8, 2009. by ... A case published in BMJ Case Reports this week raises an interesting question about plant sterol-enriched margarines and ... Extravascular lipid deposit (xanthelasma) induced by a plant sterol-enriched margarine. BMJ Case Reports 2009 [doi:10.1136/bcr. ... In this report a lady developed xanthelasma 18 months into a programme of cholesterol reduction with plant sterols. ...
https://blogs.bmj.com/case-reports/2009/08/08/plant-sterol-enriched-margarine-causing-xanthelasma/
Sterol O-acyltransferase 1 | DrugBank OnlineSterol O-acyltransferase 1 | DrugBank Online
Sterol O-acyltransferase 1. Details. Name. Sterol O-acyltransferase 1. Kind. protein. Organism. Humans. Protein. Name. UniProt ... Sterol O-acyltransferase 1. P35610. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ...
https://go.drugbank.com/bio_entities/BE0000105
Sterol regulatory element-binding protein articles organized by Serendeputy, newsfeed engine for the open webSterol regulatory element-binding protein articles organized by Serendeputy, newsfeed engine for the open web
Sterol regulatory element-binding protein tag sponsored by:. Top 25+ Sterol regulatory element-binding protein products on ...
https://serendeputy.com/sterol-regulatory-element-binding-protein
PLANT STEROLS 500 mgPLANT STEROLS 500 mg
The information on this site is for information purposes only and is not intended as a substitute for advice from a physician or other health care professional or any information contained in product labeling. Consult a healthcare professional before starting any diet, supplement, or exercise program, before taking any medication, or if you have or suspect you might have a health problem ...
https://bluebonnetnutrition.com/product-tag/lower-cholesterol/
Sterols - Radio Maria USASterols - Radio Maria USA
Tag: Sterols. August 17, 2013 - Diet and Disease: Cardiovascular Disorders. Posted on August 17, 2013. May 26, 2021. by fhare ...
https://radiomaria.us/tag/sterols/
Plant Sterols Market Analysis Report - Industry Size, Trends, Insights, Market Share, Competition, Opportunities, and Growth...Plant Sterols Market Analysis Report - Industry Size, Trends, Insights, Market Share, Competition, Opportunities, and Growth...
The Global Plant Sterols Market study is a comprehensive report with in-d ... strong, 2022 Plant Sterols Market Data, Growth Trends and Outlook to 2029,/strong,,br, ... 12.1 Global Plant Sterols Market Volume (Tons). 12.1 Global Plant Sterols Trade and Price Analysis 12.2 Plant Sterols Parent ... 12.1 Global Plant Sterols Market Volume (Tons). 12.1 Global Plant Sterols Trade and Price Analysis 12.2 Plant Sterols Parent ...
https://www.bharatbook.com/report/1356729/plant-sterols-market-analysis-report-industry-size-trends-insights-market-share-competition-opportunities-and-growth-forecasts-by-segments-to
Method development for the analysis of steroids, steroid acids and sterol sulfates in biological samplesMethod development for the analysis of steroids, steroid acids and sterol sulfates in biological samples
Junker, Julia (2021): Method development for the analysis of steroids, steroid acids and sterol sulfates in biological samples ... Method development for the analysis of steroids, steroid acids and sterol sulfates in biological samples ... Method development for the analysis of steroids, steroid acids and sterol sulfates in biological samples ...
https://edoc.ub.uni-muenchen.de/28012/
Altered sterol composition renders yeast thermotolerantAltered sterol composition renders yeast thermotolerant
... caused by mutations in the C-5 sterol desaturase gene, and increased expression of genes involved in sterol biosynthesis. ... and metabolic-flux analyses revealed a change in sterol composition, from ergosterol to fecosterol, ... caused by mutations in the C-5 sterol desaturase gene, and increased expression of genes involved in sterol biosynthesis. ... Altered sterol composition renders yeast thermotolerant Journal article, 2014 Ethanol production for use as a biofuel is mainly ...
https://research.chalmers.se/en/publication/218719
Effects of Plant Sterols & Glucomannan on Hyperlipidemia | Book by Roula Barake | Best Price in India | 9783639067323Effects of Plant Sterols & Glucomannan on Hyperlipidemia | Book by Roula Barake | Best Price in India | 9783639067323
Buy Effects of Plant Sterols & Glucomannan on Hyperlipidemia online for Rs. (4281) - Free Shipping and Cash on Delivery All ... Effects of Plant Sterols & Glucomannan on Hyperlipidemia by Roula Barake. ... Buy Books Online , Dietetics & nutrition , Effects of Plant Sterols & Glucomannan on Hyperlipidemia ...
http://books.rediff.com/book/effects-of-plant-sterols---glucomannan-on-hyperlipidemia/9783639067323?sc_cid=browse
Sterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection - CABSterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection - CAB
The C-8 sterol isomerase HYDRA1 (HYD1), an enzyme involved in isoprenoid biosynthesis and cell membrane biology, and required ... Sterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection. Plant Cell and ... Sterol isomerase HYDRA1 interacts with RNA silencing suppressor P1b and restricts potyviral infection. ...
https://cab.inta-csic.es/publicaciones/sterol-isomerase-hydra1-interacts-with-rna-silencing-suppressor-p1b-and-restricts-potyviral-infection/
Potential of the desert Locust Schistocerca gregaria (Orthoptera: Acrididae) as an unconventional source of dietary and...Potential of the desert Locust Schistocerca gregaria (Orthoptera: Acrididae) as an unconventional source of dietary and...
... among which are sterols. In this study, we sought to profile sterols and their derivatives present in the desert locust, ... as an unconventional source of dietary and therapeutic sterols. ...
http://www.indiaenvironmentportal.org.in/content/411921/potential-of-the-desert-locust-schistocerca-gregaria-orthoptera-acrididae-as-an-unconventional-source-of-dietary-and-therapeutic-sterols/?page=
EstersPhytosterolsStigmasterolBeta-SitosterolSteroidsBiosynthesisStanolCell membraneLipidContains plant sterolsPlant2022SynthesisLipidsPhospholipidsFree fattyFatsCompoundsRegulatoryVitroTriterpenesPathwayAcyltransferaseInteractsPlasma membraneProteinVegetable oilsProteinsCapsulesMembranesDerivativesDietary supplementNutritionComplexBacteriaProductsFoodsImmuneEffects
Esters9
  • These and other findings support the FDA-authorized health claim interim final rule stating, "A diet low in saturated fat and cholesterol including two servings of foods containing plant sterol or stanol esters supplying at least 1.3 plant sterols or 3.4 g plant stanols a day may reduce the risk of heart disease. (chiro.org)
  • CardioAid®-S Plant Sterol Esters is a combination of the ester forms of Beta-Sitosterol, Campesterol and Stigmasterol. (bulkapothecary.com)
  • Foods containing at least 0.65 grams per serving of plant sterol esters, eaten twice a day with meals for a daily total intake of at least 1.3 grams, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. (bulkapothecary.com)
  • A serving of NOW® Beta-Sitosterol Plant Sterols with Fish Oil supplies 1 gram (1,000 mg) of plant sterol esters in a base of fish oil. (bulkapothecary.com)
  • Bound fatty acids from acylglycerols, alkylacylglycerols, galactosyldiacylglycerols, glycerophospholipids, and sterol esters are derivatized by using transesterification with sodium methoxide to form fatty acid methyl esters. (vtt.fi)
  • Phytosterols, also called plant sterols or stanol esters, are specialized compounds found in plants that are structurally similar to cholesterol found in humans. (medindustry-pharmaday.de)
  • Sterols can be conjugated to fatty acids, fatty acid esters, and sugars. (news-medical.net)
  • Plant Sterol Esters look similar in structure to cholesterol, so they compete with and block about 50% of cholesterol from food and bile from being absorbed. (annasvitaminsplus.com)
  • Even a healthy diet does not provide enough Plant Sterol Esters to lower cholesterol, so supplementation is necessary to achieve adequate cholesterol-lowering doses. (annasvitaminsplus.com)
Phytosterols6
  • Fruits and vegetables contain health-promoting compounds called phytosterols, specifically sterols and stanols. (chiro.org)
  • Sterols of plants are called phytosterols and sterols of animals are called zoosterols . (wikipedia.org)
  • Phytosterols , more commonly known as plant sterols, have been shown in clinical trials to block cholesterol absorption sites in the human intestine, thus helping to reduce cholesterol absorption in humans. (wikipedia.org)
  • Sterols are also known as Phytosterols. (herbpathy.com)
  • plant sterols or phytosterols are structurally similar to cholesterol and exist in several forms in plants, including sitosterol, campesterol, stigmasterol and cycloartenol. (medindustry-pharmaday.de)
  • Phytosterols and phytostanols, also referred to as plant sterols and stanols, are common plant and vegetable constituents and are therefore normal constituents of the human diet. (medindustry-pharmaday.de)
Stigmasterol2
  • This potent natural powerhouse consists of an 8-Complex formula that includes Plant Sterols Such As Beta-Sitosterol, Stigmasterol, And Campesterol, as well as Energy Substrates, Essential Fatty Acids (EFAs), Performance Boosters, Nucleosides, and Antioxidants. (illpumpyouup.com)
  • The plant sterols sitosterol and stigmasterol exert very different effects on plant model membranes, the first one beingeinforcer like cholesterol, the second one not. (medindustry-pharmaday.de)
Beta-Sitosterol1
  • It also provide phyto-Lipids, omega 6 and omega 3 fatty acids, phyto Sterols beta sitosterol, gamma oryzanol etc. (jiji.ng)
Steroids3
  • Therefore, sterols are a subgroup of the steroids. (wikipedia.org)
  • Sterols are a subgroup of steroids with a hydroxyl group at the 3-position of the A-ring. (wikipedia.org)
  • Topics covered include qualitative and quantitative analysis of plant sterols by gasliquid chromatography raman spectroscopy of steroids nuclear magnetic resonance and applications of lanthanide shift reagents.omputerized method for rapid comparison and retrieval of infrared spectral data is also described. (medindustry-pharmaday.de)
Biosynthesis6
  • A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. (hindawi.com)
  • Evidence supporting a role for sterols in the development of ASD was based on studies in disorders of sterol biosynthesis, chiefly SLOS [ 5 - 8 ]. (hindawi.com)
  • 40 degrees C. Sequencing of the whole genome, genome-wide gene expression, and metabolic-flux analyses revealed a change in sterol composition, from ergosterol to fecosterol, caused by mutations in the C-5 sterol desaturase gene, and increased expression of genes involved in sterol biosynthesis. (chalmers.se)
  • The C-8 sterol isomerase HYDRA1 (HYD1), an enzyme involved in isoprenoid biosynthesis and cell membrane biology, and required for RNA silencing, was isolated in this screen. (inta-csic.es)
  • The SCP2-thiolase is part of a unidirectional two-step bridge between the fatty acid precursor, acetyl-CoA, and the precursor of the mevalonate pathway leading to sterol biosynthesis, 3-hydroxy-3-methylglutaryl-CoA. (pasteur.fr)
  • We confirmed this by showing that PM to ER sterol transport slows dramatically in mutants with conditional defects in PIP biosynthesis. (rupress.org)
Stanol3
  • The American Heart Association recommends eating sterol and stanol fortified foods if you're trying to lower your high cholesterol. (webmd.com)
  • 1. Law M. Plant sterol and stanol margarines and health. (chiro.org)
  • 2008. Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment. (csic.es)
Cell membrane3
  • [1] [2] The most familiar type of animal sterol is cholesterol , which is vital to cell membrane structure, and functions as a precursor to fat-soluble vitamins and steroid hormones . (wikipedia.org)
  • Ergosterol is a sterol present in the cell membrane of fungi, where it serves a role similar to cholesterol in animal cells. (wikipedia.org)
  • Outside of the cell membrane, sterols, particularly cholesterols, are precursor of bile acids, vitamin D and steroidal hormones. (news-medical.net)
Lipid3
  • The total lipid, lipid class, neutral lipid fraction fatty acid and sterol content and composition of whole krill, their digestive glands, and stomachs during the late-summer were examined. (edu.au)
  • Alongside sphingolipids, sterols may form structures called lipid rafts which are implicated in signaling and membrane trafficking. (news-medical.net)
  • Tre-en-en is a Grain concentrates that provides lipid and sterols which feeds your cells with an exclusive whole food blend of extracts from wheat, rice and soya. (jiji.ng)
Contains plant sterols2
  • Last year our sister site BakeryAndSnacks.com reported on the development of a California-style thin crust pizza from Road Pizza Company which contains plant sterols in the dough base and cheese topping. (nutraingredients-usa.com)
  • This powerful formula contains plant sterols, EFA's, performance boosters, nucleosides & antioxidants - the legendary Natural Sterol Complex! (illpumpyouup.com)
Plant51
  • Functional snack company Corazonas is launching potato chips containing plant sterols for cholesterol reduction, and claims to be the first manufacturer to take the healthy ingredient into this kind of snack product. (nutraingredients-usa.com)
  • Corazonas, however, is targeting both angles by including plant sterols but absolutely no trans fats. (nutraingredients-usa.com)
  • A spokesperson for Mintel confirmed that it has no other plant sterol-containing potato chips listed in its Global New Products Database in the United States. (nutraingredients-usa.com)
  • She said Corazonas' launch is "definitely innovative", ​ but noted that there are other potato chip products in the heart healthy space - albeit not with plant sterols. (nutraingredients-usa.com)
  • Corazonas has not given details of the source of its plant sterols, but the technology to create such the product without impairing its intrinsic flavour is understood to have come from a collaboration with Brandeis University. (nutraingredients-usa.com)
  • No details of this technology have been released, beyond that it is a patented process for infusing plant sterols into the product. (nutraingredients-usa.com)
  • Plant sterols have most commonly been used in dairy products, such as yoghurt shots, margarine spreads, and juice drinks. (nutraingredients-usa.com)
  • Plant sterols and stanols have an especially valuable role. (webmd.com)
  • According to the National Cholesterol Education Program, you need 2 grams of plant sterols and stanols a day to lower your cholesterol. (webmd.com)
  • In results of a recent meta-analysis, plant sterols and stanols lowered LDL cholesterol concentrations in a dose-dependent way. (chiro.org)
  • Serum cholesterol, cholesterol precursors and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol-ester treatment. (chiro.org)
  • At present, the American Heart Association has recommended that supplemental plant sterols be taken only by those diagnosed with elevated cholesterol, and has particularly recommended that they not be taken by pregnant women or nursing mothers. (wikipedia.org)
  • Do we need to be buying plant sterols? (wikipedia.org)
  • Almost one-third of cholesterol reductions achieved by consuming a heart-healthy diet are due to plant sterols, suggests a new study from Canada that supports the ingredient's efficacy. (nutraingredients.com)
  • Forty-two subjects with high cholesterol levels were assigned to eat a diet high in soy protein, viscous fibres, and almonds for 80 weeks, and supplemented with plant sterols. (nutraingredients.com)
  • "In the context of a low-saturated fat diet and in combination with other cholesterol-lowering dietary components, plant sterols appear to exert a very significant effect on LDL-C reduction of the order of 10 per cent for two grams per day of plant sterols," ​ wrote lead author David Jenkins from St Michael's Hospital, Toronto. (nutraingredients.com)
  • This figure is similar to studies where plant sterols have been given as the only cholesterol-lowering agent. (nutraingredients.com)
  • In addition, plant sterols were taken (one gram per 1,000 kcal), except during weeks 52 to 62. (nutraingredients.com)
  • Over the course of the study, LDL-cholesterol levels decreased by an average of 15.4 per cent, while such reductions were only 9.0 per cent in the absence of plant sterols. (nutraingredients.com)
  • The results showed, state Jenkins and co-workers, that plant sterols contribute over one-third of the LDL-cholesterol reductions observed in combination with other cholesterol-lowering foods. (nutraingredients.com)
  • "Increased plant sterol intakes are likely to have been a part of the ancestral human diet at about one gram per day and are part of a more plant-based diet as currently recommended for CHD risk reduction, including green leafy vegetables, raw or dry roasted nuts, and non-hydrogenated vegetable oils," ​ wrote the researchers. (nutraingredients.com)
  • "Plant sterols therefore appear a good fit with other cholesterol-lowering components in a dietary portfolio to reduce CHD risk," ​ they concluded. (nutraingredients.com)
  • The tariff classification of plant sterol products from Germany. (faqs.org)
  • The sample, CardioAid Plant Sterols, was forwarded to the Customs and Border Protection laboratory for analysis. (faqs.org)
  • The laboratory found the sample of CardioAid Plant Sterols to be composed of 100 percent plant sterols. (faqs.org)
  • CardioAid Plant Sterols will be packed in 25-kg bags or 500-kg totes. (faqs.org)
  • Plant sterol enriched margarines increase cardiovascular risk? (bmj.com)
  • A case published in BMJ Case Reports this week raises an interesting question about plant sterol-enriched margarines and cardiovascular risk. (bmj.com)
  • In this report a lady developed xanthelasma 18 months into a programme of cholesterol reduction with plant sterols. (bmj.com)
  • The Global Plant Sterols Market study is a comprehensive report with in-depth qualitative and quantitative research evaluating the current scenario and analyzing prospects in Plant Sterols Market over the next seven years, to 2029. (bharatbook.com)
  • Robust changes brought in by the pandemic COVID-19 in the Plant Sterols supply chain and shifts in consumer behavior are necessitating the business players to be more vigilant and forward-looking to stay ahead in the competition. (bharatbook.com)
  • The economic and social impact of COVID is noted to be highly varying between different countries/markets and Plant Sterols market players are designing country-specific strategies. (bharatbook.com)
  • The research report covers Plant Sterols industry statistics including current Plant Sterols Market size, Plant Sterols Market Share, and Growth Rates (CAGR) by segments and sub-segments at global, regional, and country levels, with an annual forecast till 2029. (bharatbook.com)
  • The study provides a clear insight into market penetration by different types, applications, and sales channels of Plant Sterols with corresponding future potential, validated by real-time industry experts. (bharatbook.com)
  • Further, Plant Sterols market share by key metrics such as manufacturing methods/technology and raw material can be included as part of customization. (bharatbook.com)
  • The report identifies the most profitable products of Plant Sterols market, dominant end uses and evolving distribution channel of the Plant Sterols Market in each region. (bharatbook.com)
  • Plant Sterols Market Revenue is expected to grow at a healthy CAGR propelled by staggering demand from millennials and emerging markets. (bharatbook.com)
  • Technological advances in the Plant Sterols market enabling efficient production, expanding product portfolio, sophisticated design and packaging, effective operational maintenance, and sales monitoring are key growth drivers. (bharatbook.com)
  • However, complying with stringent regulations and varying standards around the world, growing competition, inflation estimated to remain above the upper band during the short term in key nations, and fluctuating raw material prices are some of the Plant Sterols market restraints over the forecast period. (bharatbook.com)
  • Mergers and acquisitions to acquire new technologies, strengthen portfolios, and leverage capabilities to remain key strategies of top companies in the Plant Sterols industry over the outlook period. (bharatbook.com)
  • The research analyses various direct and indirect forces that can potentially impact the Plant Sterols market supply and demand conditions. (bharatbook.com)
  • Geopolitical analysis, demographic analysis, and porters' five forces analysis are prudently assessed to estimate the best Plant Sterols market projections. (bharatbook.com)
  • Regulations, Beneficial Alternative, and Cost of Substitute in Plant Sterols market. (bharatbook.com)
  • Plant Sterols are plant-derived compounds that are structurally similar to cholesterol so that they help to limit the absorption of cholesterol from the digestive tract. (bulkapothecary.com)
  • Uid phase separation into liquiddisordered ld and liquid plant sterols are structurally related to cholesterol and are ordered lo, domains 1921. (medindustry-pharmaday.de)
  • Plant sterols in bile, but with perfusion of hdl, the secretion of plant sterols was increased two to threefold.0005. (medindustry-pharmaday.de)
  • the increase in biliary plant sterols was detected 510 min after hdl was added to perfusates and was similarly large for. (medindustry-pharmaday.de)
  • And for good reason-the creamy green fruits are packed with monounsaturated fats (MUFAs) , fiber, folate, and plant sterols that boast benefits from head to toe ( Rodale's The Fat Cell Solution proves the power of fat-hundreds of women lost weight by eating more fat, which helped train their fat cells to release excess calories). (prevention.com)
  • Consuming 1.5-2.4g of plant sterols per day can lower ldl cholesterol by 7-10% in 2-three weeks when consumed as part of a nutritious diet and life-style. (ambienknowledgebase.com)
  • Do plant sterols really lower cholesterol? (bestsourcenutrition.com)
  • 2004. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. (csic.es)
20221
  • New York, United States, 2022-Jun-09 - /EPR Network/ - Introduction Sterol ester is created when sterol and a fatty acid are synthesised (esterification). (express-press-release.net)
Synthesis4
  • Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol synthesis, while leucine only contributes to sterol production in the tsetse fly midgut stage of the parasite. (pasteur.fr)
  • We also observed a preference for fatty acids synthesis from ketogenic carbon sources, since blocking acetyl-CoA production from both glucose and threonine abolished acetate incorporation into sterols, while incorporation of acetate into fatty acids was increased. (pasteur.fr)
  • Of these, UDP-sugar: sterol glucosyltransferases (UGTs) (2.4.1.173) catalyse the synthesis of therapeutically important steryl glycosides (SGs). (northumbria.ac.uk)
  • The sterol 12alpha-hydroxylase is involved in bile acid synthesis, and results in the production of cholic acid. (avhandlingar.se)
Lipids1
  • While technically alcohols, sterols are classified by biochemists as lipids ( fats in the broader sense of the term). (wikipedia.org)
Phospholipids3
  • We conclude that the nature of unsaturated phospholipids (POPC versus DOPC) in bilayers has major effects on the properties of ceramide gel phases and on sterol-ceramide-phospholipid interactions in such complex bilayers. (abo.fi)
  • Effect of weak constant magnetic field on the composition in all treatments, pmf increased the ratio of phospholipids to sterols by 30100. (medindustry-pharmaday.de)
  • Sterols interact with phospholipids to stiffen and impermeabilize the membrane. (news-medical.net)
Free fatty2
  • monoglycerides mgs, diglycerides dgs, sterols, and free fatty acids ffas in vco and rco were converted into dioxaphosphola. (medindustry-pharmaday.de)
  • Besides, free fatty acids work to support cellular function and maca has about 20 of these high-fliers including, vitamins , minerals, sterols, and glucosinolates. (healthinsiders.com)
Fats1
  • Readers will recall that fats (sterols) were recently recovered from a 558 million-year-old fossil entity, Dickinsonia, which was previously uncertainly classified but is now classified as an animal as a result. (uncommondescent.com)
Compounds2
  • Sterols and related compounds play essential roles in the physiology of eukaryotic organisms. (wikipedia.org)
  • Sterols are natural compounds that are found in cell membranes of cereals, vegetables, and nuts. (alliedmarketresearch.com)
Regulatory2
  • Sterol regulatory element-binding protein-1 (SREBP-1) mature form was increased approximately 6-fold by this drug. (eurekamag.com)
  • Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. (proteopedia.org)
Vitro1
  • N-terminally histidine tagged proteins were purified for in vitro assays against a panel of sterol and steroidal acceptors. (northumbria.ac.uk)
Triterpenes3
  • IMSEAR at SEARO: Cytotoxic Triterpenes and Sterols from Pipturus arborescens (Link) C.B. Rob. (who.int)
  • Reyes Mariquit M De Los, Oyong Glenn G, Ebajo Virgilio D, Ng Vincent Antonio S, Shen Chien-Chang, Ragasa Consolacion Y. Cytotoxic Triterpenes and Sterols from Pipturus arborescens (Link) C.B. Rob. (who.int)
  • Triterpenes and sterols such inotodiol, trametenolic acid, and betulinic acid, among others, can be isolated with the help of the chaga mushroom. (pure5extraction.com)
Pathway5
  • For instance, (i) deletion of the gene encoding isovaleryl-CoA dehydrogenase, involved in the leucine degradation pathway, abolished leucine incorporation into sterols, and (ii) RNAi-mediated down-regulation of the SCP2-thiolase gene expression abolished incorporation of the three ketogenic carbon sources into sterols. (pasteur.fr)
  • Recent observations from a genetic screen suggest that the C. neoformans sterol homeostasis pathway is required for growth at elevated pH. (duke.edu)
  • We find that the sterol homeostasis pathway is necessary for growth in an alkaline environment and that an elevated pH is sufficient to induce Sre1 activation. (duke.edu)
  • This mechanism, which is intimately linked with fungal membrane sterol homeostasis, is independent of the previously well-studied alkaline response Rim pathway. (duke.edu)
  • In yeast, one such pathway transfers sterols from the plasma membrane (PM) to the endoplasmic reticulum (ER). (rupress.org)
Acyltransferase3
  • Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Harvard Catalyst Profiles by year, and whether "Phosphatidylcholine-Sterol O-Acyltransferase" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles. (harvard.edu)
Interacts1
  • It is not known whether it interacts with sterols, such as cholesterol, or whether it interacts with another-sterol regulated protein. (embl.de)
Plasma membrane1
  • Hernandez, A, Cooke, DT & Clarkson, DT 1998, ' Effects of abnormal-sterol accumulation on Ustilago maydis plasma membrane H + - ATPase stoichiometry and polypeptide pattern ', Journal of Bacteriology , vol. 180, pp. 412 - 415. (bris.ac.uk)
Protein1
  • Sterol Carrier Protein 2 Antibody is a Rabbit Polyclonal against Sterol Carrier Protein 2. (abbexa.com)
Vegetable oils4
  • For commercial purposes, sterols are obtained from vegetable oils such as soybean oil, sunflower oil, corn oil, and rapeseed oil. (alliedmarketresearch.com)
  • Rapid determination of sterols in vegetable oils by CEC using methacrylate ester-based monolithic columns. (bvsalud.org)
  • A method for the determination of sterols in vegetable oils by CEC with UV-Vis detection , using methacrylate ester -based monolithic columns, has been developed. (bvsalud.org)
  • The method was applied to the determination of sterols in vegetable oils with different botanical origins and to detect olive oil adulteration with sunflower and soybean oils . (bvsalud.org)
Proteins1
  • Sterols have a fundamental effect in membrane properties, affecting fluidity, membrane transport and function of membrane proteins. (news-medical.net)
Capsules1
  • Sterols are primarily are used in manufacturing dietary supplements and foods in the form of oil, powder, and soft-gelatin capsules. (alliedmarketresearch.com)
Membranes3
  • Sterols are moved between cellular membranes by nonvesicular pathways whose functions are poorly understood. (rupress.org)
  • In addition, Osh4p transfers sterols more rapidly between membranes containing phosphoinositides (PIPs), suggesting that PIPs regulate sterol transport by ORPs. (rupress.org)
  • Specifically, sterols may eliminate this ability of membranes to transition. (news-medical.net)
Derivatives1
  • In this study, we sought to profile sterols and their derivatives present in the desert locust, Schistocerca gregaria, focusing on those with potential importance as dietary and therapeutic components for humans. (org.in)
Dietary supplement1
  • Surge in use of sterols by dietary supplement manufacturers, diary industry, bakeries, and confectionary has fueled up the demand for sterols in the global market. (alliedmarketresearch.com)
Nutrition3
  • Universal Nutrition Natural Sterol Complex has been the bodybuilder's solution for decades! (illpumpyouup.com)
  • The legendary Natural Sterol Complex by Universal Nutrition is the natural solution that serious bodybuilders have been waiting for. (illpumpyouup.com)
  • If You Want Results, It's Time For Natural Sterol Complex by Universal Nutrition! (illpumpyouup.com)
Complex2
  • There's no question, Natural Sterol Complex stands alone by combining so many effective natural ingredients into one amazing formula. (illpumpyouup.com)
  • Natural Sterol Complex supports size, density, performance and recovery. (illpumpyouup.com)
Bacteria1
  • Antimicrobial properties reduce bacteria build up, while sterols detoxify pores. (luxebotanics.com)
Products1
  • Insects are increasingly being recognized not only as a source of food to feed the ever growing world population but also as potential sources of new products and therapeutic agents, among which are sterols. (org.in)
Foods2
  • The amount of natural sterols and stanols in these foods is a good bit lower than the daily amount you'd need to lower your cholesterol. (webmd.com)
  • Though taking supplements is better than getting no sterols or stanols in your diet at all, it's usually better to get your nutrients naturally from whole foods when you can. (webmd.com)
Immune1
  • Sterols boosts the Immune and treats Cold and Flu. (herbpathy.com)
Effects1
  • In summary, we found that in the gel phase, sterol effects on the PCer-rich gel phase were markedly influenced by the acyl chain composition of the fluid PC. (abo.fi)
Lipid Types: Storage, Structural Lipids & Others
Lipid Types: Storage, Structural Lipids & Others (news-medical.net)
Composition LAVERA Basis sensitiv - Fusscreme - UFC-Que Choisir
Composition LAVERA Basis sensitiv - Fusscreme - UFC-Que Choisir (quechoisir.org)
Sterols and Stanols: What to Know
Sterols and Stanols: What to Know (webmd.com)
List of Fortified Foods | livestrong
List of Fortified Foods | livestrong (livestrong.com)
Sterols | Semantic Scholar
Sterols | Semantic Scholar (semanticscholar.org)
Red Yeast Rice Supplement Reviews & Top Pick - ConsumerLab.com
Red Yeast Rice Supplement Reviews & Top Pick - ConsumerLab.com (consumerlab.com)
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology (medscape.com)
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology
Chronic Kidney Disease (CKD): Practice Essentials, Pathophysiology, Etiology (medscape.com)
7 Ways to Optimize Your Cholesterol
7 Ways to Optimize Your Cholesterol (betternutrition.com)
Hypothesis: The Role of Sterols in Autism Spectrum Disorder
Hypothesis: The Role of Sterols in Autism Spectrum Disorder (hindawi.com)
How Phytosterols Can Help Lower Your Cholesterol
How Phytosterols Can Help Lower Your Cholesterol (verywellhealth.com)
Progressive Labs
Progressive Labs (pureformulas.com)
Sitosterolemia: MedlinePlus Genetics
Sitosterolemia: MedlinePlus Genetics (medlineplus.gov)
Familial Hypercholesterolemia Treatment & Management: Medical Care, Risk Categories, Treatment Recommendations for Homozygous FH
Familial Hypercholesterolemia Treatment & Management: Medical Care, Risk Categories, Treatment Recommendations for Homozygous FH (medscape.com)
EWG Skin Deep® | Pipette Belly Butter Rating
EWG Skin Deep® | Pipette Belly Butter Rating (ewg.org)
EWG Skin Deep® | Pura D'or Intense Therapy Conditioner Rating
EWG Skin Deep® | Pura D'or Intense Therapy Conditioner Rating (ewg.org)
Met Slim Pro Reviews: Real Full List Of ingredients!! Supplement Review By DietCare Reviews - LA Weekly
Met Slim Pro Reviews: Real Full List Of ingredients!! Supplement Review By DietCare Reviews - LA Weekly (laweekly.com)
How to Lower Cholesterol with Diet: MedlinePlus
How to Lower Cholesterol with Diet: MedlinePlus (medlineplus.gov)
ABCG8 gene: MedlinePlus Genetics
ABCG8 gene: MedlinePlus Genetics (medlineplus.gov)
Animal Studies related terms, short phrases and...
"Animal Studies" related terms, short phrases and... (keywen.com)
Marine Drugs | Free Full-Text | New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
Marine Drugs | Free Full-Text | New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon (mdpi.com)
Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence...
Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence... (nutritionandmetabolism.biomedcentral.com)
Portfolio beats low-fat diet for lowering cholesterol - Harvard...
"Portfolio" beats low-fat diet for lowering cholesterol - Harvard... (health.harvard.edu)
Familial Hypercholesterolemia Clinical Presentation: History, Physical, Causes
Familial Hypercholesterolemia Clinical Presentation: History, Physical, Causes (medscape.com)
EWG rating for Physicians Formula Murumuru Butter Lip Cream, Acai Berry, SPF 15; | EWG's Guide to Sunscreens
EWG rating for Physicians Formula Murumuru Butter Lip Cream, Acai Berry, SPF 15; | EWG's Guide to Sunscreens (ewg.org)
Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Full Report | NHLBI, NIH
Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Full Report | NHLBI, NIH (nhlbi.nih.gov)