Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)Somatotypes: Particular categories of body build, determined on the basis of certain physical characteristics. The three basic body types are ectomorph (thin physique), endomorph (rounded physique), and mesomorph (athletic physique).Motor Neurons: Neurons which activate MUSCLE CELLS.Weight Lifting: A sport in which weights are lifted competitively or as an exercise.Pursuit, Smooth: Eye movements that are slow, continuous, and conjugate and occur when a fixed object is moved slowly.Neuromuscular Diseases: A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.Bulbar Palsy, Progressive: A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Foundations: Organizations established by endowments with provision for future maintenance.Doping in Sports: Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Sports Medicine: The field of medicine concerned with physical fitness and the diagnosis and treatment of injuries sustained in exercise and sports activities.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Holidays: Days commemorating events. Holidays also include vacation periods.EssaysSteroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Writing: The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.History, 20th Century: Time period from 1901 through 2000 of the common era.History, 19th Century: Time period from 1801 through 1900 of the common era.History, 18th Century: Time period from 1701 through 1800 of the common era.Physiology: The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.Medicine in Literature: Written or other literary works whose subject matter is medical or about the profession of medicine and related areas.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Breast Neoplasms: Tumors or cancer of the human BREAST.Steroid 21-Hydroxylase: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Anabolic Agents: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/3349)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities.  (+info)

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment. (2/3349)

AIM: To examine the effect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. METHODS: Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 blocks); (3) Crohn's disease treated with high dose corticosteroids (12 patients, 24 blocks); (4) Non-inflammatory, non-neoplastic controls (four patients, six blocks). Full thickness paraffin sections of colons removed at surgery were immunostained with an antibody raised against the C terminal end of iNOS. Sections were assessed semiquantitatively for the presence and degree of inflammation and immunoreactivity for nitric oxide synthase. RESULTS: Cases of ulcerative colitis and Crohn's disease with active inflammation showed strong staining for nitric oxide synthase. The staining was diffuse in ulcerative colitis and patchy in Crohn's disease, in accordance with the distribution of active inflammation. Staining was seen in epithelial cells and was most intense near areas of inflammation such as crypt abscesses. Non-inflamed epithelium showed no immunoreactivity. Treatment with corticosteroids made no difference to the amount of nitric oxide synthase. CONCLUSIONS: Expression of nitric oxide synthase is increased in both ulcerative colitis and Crohn's disease and appears to be unaffected by treatment with corticosteroids. Disease severity necessitated surgery in all the cases included in this study, regardless of whether or not the patients had received long term corticosteroid treatment. It seems therefore that a high level of iNOS expression and, presumably, production of nitric oxide characterise cases which are refractory to clinical treatment; this suggests that specific inhibition of the enzyme may be a useful therapeutic adjunct.  (+info)

Analysis of Chinese herbal creams prescribed for dermatological conditions. (3/3349)

OBJECTIVE: To determine whether Chinese herbal creams used for the treatment of dermatological conditions contain steroids. DESIGN: 11 herbal creams obtained from patients attending general and paediatric dermatology outpatient clinics were analysed with high resolution gas chromatography and mass spectrometry. SETTING: Departments of dermatology and clinical biochemistry. MAIN OUTCOME MEASURE: Presence of steroid. RESULTS: Eight creams contained dexamethasone at a mean concentration of 456 micrograms/g (range 64 to 1500 micrograms/g). All were applied to areas of sensitive skin such as face and flexures. CONCLUSION: Greater regulation needs to be imposed on Chinese herbalists to prevent illegal and inappropriate prescribing of potent steroids.  (+info)

Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. (4/3349)

The familial form of hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder. Although the prognosis for Epstein-Barr virus-associated HLH (EBV-HLH) remains uncertain, numerous reports indicate that it can also be fatal in a substantial proportion of cases. We therefore assessed the potential of immunochemotherapy with a core combination of steroids and etoposide to control EBV-HLH in 17 infants and children who met stringent diagnostic criteria for this reactive disorder of the mononuclear phagocyte system. Treatment of life-threatening emergencies was left to the discretion of participating investigators and typically included either intravenous Ig or cyclosporin A (CSA). Five patients (29%) entered complete remission during the induction phase (1 to 2 months), whereas 10 others (57%) required additional treatment to achieve this status. In 2 cases, immunochemotherapy was ineffective, prompting allogeneic bone marrow transplantation. Severe but reversible myelosuppression was a common finding; adverse late sequelae were limited to epileptic activity in one child and chronic EBV infection in 2 others. Fourteen of the 17 patients treated with immunochemotherapy have maintained their complete responses for 4+ to 39+ months (median, 15+ months), suggesting a low probability of disease recurrence. These results provide a new perspective on EBV-HLH, showing effective control (and perhaps cure) of the majority of EBV-HLH cases without bone marrow transplantation, using steroids and etoposide, with or without immunomodulatory agents.  (+info)

Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. (5/3349)

A number of endogenous steroids exhibit rapid, nongenomic effects on the central nervous system and are called neuroactive steroids. The rapid mechanisms of action include modulation of gamma-aminobutyric acid type A (GABAA) and N-methyl-D-aspartate (NMDA) receptors, which are two receptors implicated in the behavioral effects of ethanol. It was hypothesized that neuroactive steroids that positively modulate GABAA receptors or negatively modulate NMDA receptors, analogous to the actions of ethanol, would produce discriminative stimulus effects similar to ethanol. Two groups of male Long-Evans rats (n = 6-8/group) were trained to discriminate between 1.0 or 2.0 g/kg ethanol (i.g.) and water (i.g.). The neuroactive steroids allopregnanolone, pregnanolone, epipregnanolone, allotetrahydrodeoxycorticosterone, pregnanolone sulfate, epipregnanolone sulfate, dehydroepiandrosterone, dehydroepiandrosterone sulfate, pregnenolone, and pregnenolone sulfate (PS), all administered i.p., were tested for substitution with acute and cumulative dosing procedures (n = 4-8/steroid). The GABAA-positive modulatory steroids allopregnanolone, pregnanolone, and allotetrahydrodeoxycorticosterone substituted for ethanol, as did the low-efficacy steroid 3beta,5beta-P. GABAA-negative modulators, such as dehydroepiandrosterone sulfate and PS, and all of the NMDA modulators tested, including PS, pregnanolone sulfate, and epipregnanolone sulfate, did not substitute for ethanol. These results show that certain endogenously occurring neuroactive steroids produce discriminative stimulus effects similar to those of ethanol.  (+info)

Clinicopathological features of Churg-Strauss syndrome-associated neuropathy. (6/3349)

We assessed the clinicopathological features of 28 patients with peripheral neuropathy associated with Churg-Strauss syndrome. Initial symptoms attributable to neuropathy were acute painful dysaesthesiae and oedema in the dysaesthetic portion of the distal limbs. Sensory and motor involvement mostly showed a pattern of mononeuritis multiplex in the initial phase, progressing into asymmetrical polyneuropathy, restricted to the limbs. Parallel loss of myelinated and unmyelinated fibres due to axonal degeneration was evident as decreased or absent amplitudes of sensory nerve action potentials and compound muscle action potentials, indicating acute massive axonal loss. Epineurial necrotizing vasculitis was seen in 54% of cases; infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. Eosinophils were present in infiltrates, but in smaller numbers than lymphocytes. CD20-positive B lymphocytes were seen only occasionally. Deposits of IgG, C3d, IgE and major basic protein were scarce. The mean follow-up period was 4.2 years, with a range of 8 months to 10 years. Fatal outcome was seen only in a single patient, indicating a good survival rate. The patients who responded well to the initial corticosteroid therapy within 4 weeks regained self-controlled functional status in longterm follow-up (modified Rankin score was < or = 2), while those not responding well to the initial corticosteroid therapy led a dependent existence (P < 0.01). In addition the patients with poor functional outcomes had significantly more systemic organ damage caused by vasculitis (P < 0.05). Necrotizing vasculitis mediated by cytotoxic T cells, leading to ischaemic changes, appears to be a major cause of Churg-Strauss syndrome-associated neuropathy. The initial clinical course and the extent of systemic vasculitic lesions may influence the long-term functional prognosis.  (+info)

Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies. (7/3349)

BACKGROUND: The therapeutic efficacy of 5-aminosalicylic acid in inflammatory bowel disease may be related to its antioxidant properties. AIM: To compare in vitro the antioxidant effects of conventional drugs (5-aminosalicylic acid, corticosteroids, metronidazole), with new aminosalicylates (4-aminosalicylic acid, balsalazide) and other potential therapies (ascorbate, N-acetylcysteine, glutathione, verapamil). METHODS: Compounds were assessed for efficacy in reducing the in vitro production of reactive oxygen species by cell-free systems (using xanthine/xanthine oxidase, with or without myeloperoxidase) and by colorectal biopsies from patients with ulcerative colitis using luminol-amplified chemiluminescence. RESULTS: 5-aminosalicylic acid and balsalazide were more potent antioxidants than 4-aminosalicylic acid or N-acetyl-5-aminosalicylic acid in cell-free systems. 5-aminosalicylic acid (20 mM) and balsalazide (20 mM) inhibited rectal biopsy chemiluminescence by 93% and 100%, respectively, compared with only 59% inhibition by 4-aminosalicylic acid (20 mM). Hydrocortisone, metronidazole and verapamil had no significant effect on chemiluminescence in any system. Ascorbate (20 mM) inhibited chemiluminescence by 100% in cell-free systems and by 60% in rectal biopsies. N-acetyl cysteine (10 mM), and both oxidized and reduced glutathione (10 mM), completely inhibited chemiluminescence in cell-free systems, but not with rectal biopsies. CONCLUSIONS: The antioxidant effects of compounds varies between cell-free systems and inflamed colorectal biopsies. The effect of drugs on the chemiluminescence produced by these two assay systems is useful for screening potentially new antioxidant treatments for inflammatory bowel disease. Ascorbate seems worth further study as a novel therapy.  (+info)

The diagnosis, classification, and management of asthma according to severity. (8/3349)

This activity is designed for primary care and specialist physicians. GOAL: To provide prompt and appropriate treatment for asthma of all levels of severity resulting in improved level of activity and decreased need for urgent care and hospitalization with a possible reduction in the annual decline of lung function, degree of permanent airway damage, and mortality. OBJECTIVES: 1. To provide a framework on the basis of history, physical findings, and laboratory results for the diagnosis of asthma. 2. To improve the ability to classify asthma by degree of severity. 3. To describe an incremental therapeutic approach to asthma by degree of severity. 4. To provide a systematic approach with regard to periodic reevaluation of asthma severity and modification of the treatment plan.  (+info)

*List of drugs banned by WADA

Banned androgenic agents are either anabolic steroids, which increase testosterone and epitestosterone, thereby improving ... are banned anabolic steroids. Beta-2 agonists can act as bronchodilators and increase heart rates, in addition to their mild ... Testosterone Metabolites and isomers of endogenous anabolic androgenic steroids, including: Clenbuterol Selective androgen ...

*Steroids (journal)

Steroids is a monthly peer-reviewed scientific journal covering all aspects of steroid hormones. It was established in 1963 and ... "Steroids". 2013 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2014. Official website. ...

*List of steroids

... may refer to: List of androgens/anabolic steroids - steroidal androgens/anabolic steroids List of androgens/ ... or inhibitors of steroid biosynthesis and metabolism As well as lists of steroid esters, including: List of androgen esters - ... anabolic steroids (alternate) - steroidal androgens/anabolic steroids List of steroidal antiandrogens - steroidal antiandrogens ... corticosteroid esters List of steroid esters List of steroid medications available in the United States. ...

*Anabolic-androgenic steroids abuse

Anabolic steroid use has been associated with an antisocial lifestyle involving various types of criminality. Steroid abuse ... Research has found that some steroid abusers turn to other drugs such as opioids to counteract the negative effects of steroids ... "even though anabolic steroids do not cause the same high as other drugs, steroids are reinforcing and can lead to addiction. ... most commonly for steroids. According to a 1998 study, 2.7% of middle school students admitted to taking steroids. 2% of non- ...

*Steroid

In eukaryotes, steroids are found in fungi, animals, and plants. Fungal steroids include the ergosterols. Animal steroids ... In popular use, the term "steroids" often refers to anabolic steroids. Plant steroids include steroidal alkaloids found in ... and many steroids are signaling molecules which activate steroid hormone receptors. The steroid core structure is composed of ... Batrachotoxin List of steroid abbreviations List of steroids Membrane steroid receptor Pheromone Reverse cholesterol transport ...

*List of androgens/anabolic steroids

List of steroids List of designer drugs § Androgens List of androgens/anabolic steroids available in the United States ? = ... Applied modifications in the steroidal structure". Steroids. 74 (2): 172-97. doi:10.1016/j.steroids.2008.10.016. PMID 19028512 ... This is a list of androgens/anabolic steroids (AAS) or testosterone derivatives. Esters are mostly not included in this list; ... "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502-521. doi:10.1038/bjp.2008.165. ISSN 0007-1188 ...

*Steroid sulfatase

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid. This includes ... "Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase". Biochemical and ... effect of IL-1beta on steroid sulfatase activity in human endometrial stromal cells". Steroids. 67 (7): 655-9. doi:10.1016/ ... Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the ...

*Anabolic steroid

Anabolic steroids, also known more properly as anabolic-androgenic steroids (AAS), are steroidal androgens that include natural ... and less frequently psychosis and suicide have been associated with steroid abuse. Long-term steroid abusers may develop ... Designer steroids are AAS that have not been approved and marketed for medical use but have been distributed through the black ... In addition, steroids provoke a rapid increase in body weight and an accompanying rise in blood pressure, both of which leave ...

*Ergogenic use of anabolic steroids

Anabolic steroid users tend to be disillusioned by the portrayal of anabolic steroids as deadly in the media and in politics. ... However, anabolic steroids were added to Schedule III of the Controlled Substances Act in the Anabolic Steroid Control Act of ... Although steroids have been known to cause liver cancer, there is no published evidence that anabolic steroids cause either ... The legal status of anabolic steroids varies from country to country. In the U.S., anabolic steroids are listed as Schedule III ...

*Steroid atrophy

Strong topical steroid (e.g., fluorinated steroids) can induce the condition very quickly, while a weaker steroid can induce it ... Generally a milder topical steroid or non-steroid treatment is used on the in-between days. Strong steroids should be avoided ... A mild topical steroid that works on the face may achieve little on the palm. But a potent steroid may quickly cause side ... "The Importance of the Topical Steroid Base". "Vehicle". "Choosing Topical Corticosteroids". "Course on topical steroids". "The ...

*Steroid sulfate

... s are endogenous sulfate esters of steroids. They are formed by steroid sulfotransferases via sulfation of ... endogenous steroids like cholesterol and steroid hormones. Although steroid sulfates do not bind to steroid hormone receptors ... Estrogen conjugate Steroid ester Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (2015). "The Regulation of Steroid ... In addition, some steroid sulfates have biological activity in their own right, for instance acting as neurosteroids and ...

*Steroid acne

... presents with monomorphous pink paupules, as well as comedones, which may be indistinguishable from those of acne ... Steroid acne is commonly associated with endogenous or exogenous sources of androgen, drug therapy, or diabetes and is less ... Steroid acne is an adverse reaction to corticosteroids, and presents as small, firm follicular papules on the forehead, cheeks ... Acne vulgaris and steroid acne are quite different processes, although the comedones may be clinically indistinguishable. ...

*Steroid hormone

A steroid hormone is a steroid that acts as a hormone. Steroid hormones can be grouped into two classes: corticosteroids ( ... Then the steroid binds to a specific steroid hormone receptor, also known as a nuclear receptor, which is a large ... Most are steroids, but some nonsteroidal molecules can interact with the steroid receptors because of a similarity of shape. ... Upon steroid binding, many kinds of steroid receptors dimerize: two receptor subunits join together to form one functional DNA- ...

*Steroid ester

List of steroid esters Steroid sulfate Vermeulen A (1975). "Longacting steroid preparations". Acta Clin Belg. 30 (1): 48-55. ... A steroid ester is an ester of a steroid. They include androgen esters, estrogen esters, progestogen esters, and corticosteroid ... Anabolic Steroids and the Athlete, 2d ed. McFarland. pp. 39-. ISBN 978-0-7864-1128-3. Vermeulen A (1975). "Longacting steroid ... Steroid esters may be naturally occurring/endogenous like DHEA sulfate or synthetic like estradiol valerate. Esterification is ...

*Antenatal steroid

The time between administration of steroids and delivery may alter the effectiveness of the steroids. Mwansa-Kambafwile, J.; ... Steroids do not appear to increase the number of women who develop infection of the fetal membranes (chorioamnionitis) or of ... Antenatal steroids are currently used up to 36 weeks in some parts of the world obstetric practice. ... Tucker, L; Hoff, C; Peevy, K; Brost, B; Holland, S; Calhoun, BC (Nov 1995). "The effects of antenatal steroid use in premature ...

*Topical steroid

The highlighted steroids are often used in the screening of allergies to topical steroid and systemic steroids. When one is ... Topical steroids are the topical forms of corticosteroids. Topical steroids are the most commonly prescribed topical ... see steroid allergy) Steroid atrophy Perioral dermatitis: This is a rash that occurs around the mouth and the eye region that ... Weaker steroids are used on the face, eyelids, diaper area, perianal skin, and intertrigo of the groin or body folds. Moderate ...

*Sex steroid

Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen ... Natural sex steroids are made by the gonads (ovaries or testes), by adrenal glands, or by conversion from other sex steroids in ... Specific compounds that have partial agonist activity for steroid receptors, and therefore act in part like natural steroid ... There are also many synthetic sex steroids. Synthetic androgens are often referred to as anabolic steroids. Synthetic estrogens ...

*Steroid rosacea

Steroid-induced rosacea can be caused by the prolonged used of a topical steroid on the face. Topical steroid comes in 7 ... from the use of either systemic steroid or topical steroids. It is nearly identical to steroid induced acne from the standpoint ... Only mild steroids should be applied to the face. The use of the topical steroid should be limited to the condition. Alternate ... If the patient is using a strong topical steroid, he or she is weaned to a weaker class VI or VII steroid. Usually, they are to ...

*Steroid-lactonase

In enzymology, a steroid-lactonase (EC 3.1.1.37) is an enzyme that catalyzes the chemical reaction testololactone + H2O ⇌ {\ ... Holmlund, Chester E.; Blank, Robert H. (1965-01-01). "Preparation and properties of a steroid lactonase". Archives of ...

*Adrenal steroid

Adrenal steroids are distinguished from gonadal steroids, which are steroids that are derived from the gonads and include sex ... Adrenal steroids are steroids that are derived from the adrenal glands. They include corticosteroids, which consist of ... Adrenal steroids are specifically produced in the zona reticularis layer of the adrenal cortex. ... steroids such as progestogens like progesterone, potent androgens like testosterone, and estrogens like estradiol.. ...

*Steroid folliculitis

... occurs following administration of glucocorticoids or corticotropin. Other medications can also mimic ... In addition to glucocorticoids, other medicines can also cause a monomorphic, diffuse popular eruption that mimics steroid ... medicine portal List of cutaneous conditions Steroid acne Freedberg, et al. (2003). Fitzpatrick's Dermatology in General ...

*Steroid Maximus

... is an instrumental side project of J.G. Thirlwell. Thirlwell is best known for his main band, Foetus. Steroid ... and instrumental works were released as Steroid Maximus. The official debut of Steroid Maximus came in 1990 with the release of ... Steroid Maximus made its live debut in Los Angeles in 2003, facilitated by a commission from UCLA. Thirlwell rearranged the ... Steroid Maximus' second album, Gondwanaland, was released in 1992. In addition to further collaboration with Raymond Watts on 6 ...

*Steroid hydroxylase

A steroid hydroxylase is a class of hydroxylase enzymes involved in the biosynthesis of steroids. Steroidogenic enzyme ... Steroidogenesis Steroid nomenclature - numbering of carbons Production of DHEA from Cholesterol Steroid hydroxylases at the US ...

*Steroid reductase

... s are reductase enzymes that are involved in steroid biosynthesis and metabolism. They include: 5α-Reductase 5 ...

*Steroid diabetes

... does not occur with other steroid hormones, such as anabolic steroids or sex steroids because these other ... Steroid diabetes (also "steroid-induced diabetes") is a medical term referring to prolonged hyperglycemia due to glucocorticoid ... it is not always possible to determine whether apparent steroid diabetes will be permanent or will go away when the steroids ... but those who cannot develop steroid diabetes. The diagnostic criteria for steroid diabetes are those of diabetes (fasting ...
Steroids are powerful drugs to overcome the inflammation and relieve pain, in addition to the steroid directly bekarja on brain chemistry is also beneficial for improving mood. Someone who is not inflamed but taking steroids can feel comfortable in a relatively cepat.Tetapi steroid use as a pain reliever and improve mood also has side effects that sometimes it membahayakan.Efek side caused by steroid use include: - Steroids can suppress immune function and increase the risk of infection. - When drunk, steroids can cause gastritis or ulcer-Steroids can stop the blood supply to the joints, especially in the thighs and cause pain degenerative called avascular necrosis. - Steroids can reduce bone mass and increase the risk of fractures bone in long-term use. - Steroids can cause the bodys ability to respond to the emotional and physical pain is reduced. - Most of taking steroids will remove fat and fluid in his body despite discontinuation of the steroid ...
Anabolic steroid profiles of popular steroids used in bodybuilding. Learn how to stack steroid cycles after reading our expertly written steroid profiles.
Norma Devine, Editor. On Wednesday, November 13, 2002, Dr. Rick Wilson, a glaucoma specialist at Wills, and the glaucoma chat group discussed "Steroid Use and IOP.". Moderator: Welcome, Dr. Rick. We have lots of newcomers tonight. The topic is "Steroid Use and Intraocular Pressure." P: When was it determined that steroids can cause elevated intraocular pressure (IOP) and glaucoma? Dr. Rick Wilson: I think it was back in the Sixties (Bernie Becker at Washington University in St. Louis, Missouri.) Moderator: Are we talking about all steroids or topical steroids?. Dr. Rick Wilson: Mostly topical. Systemic steroids act by a different mechanism, as far as we can tell, and the effect is much quicker than topical steroids.. P: What are the usual effects of steroid use on IOP? Dr. Rick Wilson: A small percent of patients will get a large rise in IOP, about a third will get a modest rise in IOP, and the rest will not get much of a rise unless the steroids are taken for a prolonged period, for example, ...
The market place is awash with different types of steroids, running into hundreds, that perform different functions. One of these variations is the anabolic steroids that also come in different types, forms, derivatives, and variations. In fact, there are countless types of anabolic steroids that discussing all of them becomes overwhelming. When thinking of using steroids, one has first to understand the types of anabolic steroids and select which the best depending with intended purpose.. To understand the different forms of steroids, it is important to grasp some of the function. Some steroids come handy in performance improvements, some for therapeutic use while the majority cut across several fields. The different types of steroids can be broken down to the hormonal classifications or even their form of administration. These above classifications results into a plethora of differing types of steroids. However, some steroids are unavailable from some markets or are so rare and exclusive to a ...
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Steroid hormones are derived from cholesterol and, unlike peptide hormones, are not stored in secretory granules. As a result, steroid secretion is limited by the rate of production. Since they are lipophilic, steroid hormones are generally cell membrane permeable. In plasma, steroid hormones are largely bound to serum proteins, with only a small "free" component available to diffuse into the intracellular space and bind receptors. Once bound to an intracellular receptor, steroids are translocated to deoxyribonucleic acid (DNA) recognition sites within the nucleus where they act by regulating the transcription of target genes. The key steroid hormones of the HPG axis are ...
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In this study we have clarified important issues pertaining to the classification of inflammatory phenotypes in asthma and their relationship to steroid response. Our principal findings are: (1) after steroid withdrawal we were unable to identify a neutrophilic phenotype in our population of patients; (2) ICS treatment was associated with increased airway neutrophils and a switch to a neutrophilic phenotype in some patients; (3) although steroid responsiveness is greater in EA, it is not exclusive to this phenotype but also occurs in NEA; and (4) Feno may be used to predict the steroid response in NEA.. Our finding of the absence of a neutrophilic phenotype after steroid withdrawal and, with steroid, of a significant increase in the proportion of sputum neutrophils (∼10%) and in the number of patients with neutrophilic asthma has significant implications. It may be that in previous studies reporting inflammatory phenotypes the results are not strictly accurate because patients were receiving ...
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Topic summary contributed by volunteer(s): Randy All animal products contain steroid hormones, and the presence of hormones in food has been connected with several human health problems. For example, steroid hormones in milk may contribute to the acne epidemic. The sex steroid hormones in meat may alter a mans testicular development in utero as well as affect female fertility. Breast cancer is sensitive to growth promoting steroid hormones like estrogen. The dramatic increase of hormone dependent cancers, including breast, ovarian, endometrial, and prostate cancer in Japan, for example, has been speculatively linked to anabolic steroids in the beef supply. Due to the possibility of dietary hormones, including steroids, being a factor in hormone-related cancers, we should consider monitoring the levels of steroids and other hormones in dairy and meat-containing foods. There may be natural alternatives to anabolic steroids. For example, a lotion made out of cilantro seeds had some ...
Steroid, or "cortisone", injections are a very common treatment for a wide range of painful or inflammatory conditions around the hand, wrist and elbow. Unlike pills, injected steroids deliver a high concentration of the medicine directly to the area of concern and minimize the side effects to the body as a whole.. The steroids that are used for injection are just one member of a large family of compounds known are hormones. The hormones produced naturally in the body regulate many biological functions such as growth, metabolism, inflammation and reaction to stress or injury. The synthetically produced steroids used for injections (e.g. betamethasone, triamcinolone) are in a group called glucocorticoids. Like their naturally occurring counterparts, this group has a number of functions including regulation of inflammation and the immune system. These the steroids should not be confused with anabolic steroids that have been misused for performance enhancement in sports. Anabolic steroids mimic the ...
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In a perfect world, the answer to the question "should someone with diabetes take steroids?" would be a simple "no". Of course, not only do we not live in a perfect world, there are also few simple answers for diabetics. Steroids can play havoc with blood sugar levels, but they can also be the best choice in treating some very serious conditions. So, perhaps the better answer would be "maybe" with the added caveat of making sure you are aware of the consequences and prepared to be proactive in managing them. Steroids are frequently prescribed to treat a wide range of conditions, some relatively minor such as rashes, muscle spasms and pain, injuries and respiratory issues. These normally require only a short period of use. They are also used long-term for conditions like certain inflammatory disorders, asthma, arthritis, autoimmune disorders and organ transplants. Steroids can be exceptionally effective. At the same time, they also significantly increase blood glucose levels in people with ...
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Steroid hormone: Steroid hormone, any of a group of hormones that belong to the class of chemical compounds known as steroids. Steroid hormones are secreted by three glands-the adrenal cortex, testes, and ovaries-and by the placenta during pregnancy. Learn more about steroid hormone classification, secretion, and function.
The athletes and bodybuilders take injectable form of steroids, in order to accelerate muscle growth, function, stamina, endurance and development. The HGH is simply not a steroid. If the terms are changed, it can be stated that some of the steroids re hormones. All this is because of the confusion, whether HGH is a steroid or not. Also, the similarity between the two is that both the HGH and the steroids can be sold legally on a prescription and illegally from the black marketers. In the medical realms, the steroids are termed as the hormones produced by several glands in the body.. The HGH is a common treatment in the form of prescription for the medical conditions that have to do with dysfunctioning of the pituitary glands and hormone levels. Also, this dysfunctioning may result in growth deficiencies in muscles, short stature as well as the conditions affecting the metabolism. The benefits of the HGH are very real. Some of the benefits of the HGH for men are listed below:. ...
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in General and Comparative Endocrinology (2008), 157(3), 266-74. Traditionally, the production and regulation of steroid hormones has been viewed as a multi-organ process involving the hypothalamic-pituitary-gonadal (HPG) axis for sex steroids and the hypothalamic ... [more ▼]. Traditionally, the production and regulation of steroid hormones has been viewed as a multi-organ process involving the hypothalamic-pituitary-gonadal (HPG) axis for sex steroids and the hypothalamic-pituitary-adrenal (HPA) axis for glucocorticoids. However, active steroids can also be synthesized locally in target tissues, either from circulating inactive precursors or de novo from cholesterol. Here, we review recent work demonstrating local steroid synthesis, with an emphasis on steroids synthesized in the brain (neurosteroids) and steroids synthesized in the immune system (immunosteroids). Furthermore, recent evidence suggests that other components of the HPG axis (luteinizing hormone and gonadotropin-releasing ...
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Steroid use (or juice in common conversation) is an American dilemma. America doesnt like losers. Little, skinny, weak can be mocked. Bigger, stronger, most beautiful, fastest, the best looking, best statistics and records, seem to be our goals. In sports and in business, in politics and diplomacy, its often "win at all costs." Steroids have been a key factor in some of our wins. Steroids have become so common that newscasters, advertisers, politicians, and many of us have used expressions like: a car, an iPad, a business deal, even a theory or policy "on steroids!". What are steroids, how common is their use, and how should we respond? First of all their chemical composition.. According to Wikipedia (which for basic scientific matters can usually be trusted):. A steroid is a type of organic compound that contains a characteristic arrangement of four cycloalkane rings joined to one another. Examples of steroids include the dietary lipid cholesterol, the sex hormones estradiol and testosterone, ...
Because the shift in the 1990s was so dramatic, its hard not to wonder what happened. There is no denying that home run balls are flying out of the park more than they used to, which makes it hard to know why steroid skeptics, such as myself, do not acknowledge steroids to be the cause. Yes, Juiced and Game of Shadows tell us that steroids were rampant in the locker rooms of MLB teams during the home run boom. I really cant argue with the fact that some players may have taken steroids. As to how much and what effect they have had on hitting power I still dont know. Its going to take more than accusations from Ken Caminiti, Jose Conseco, and anonymous sources to convince me of player guilt. Regardless of whether or not players used or not, Im still not convinced that steroids, or any other PEDs, have much to do with the increase in offense. Here are some reasons not to blame the surge on steroids.. Steroids ought to impact both sides of the ball. If there are benefits, both pitchers and ...
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Although steroids can be potent modulators of ion channels, for example, by acting on discrete activation and potentiation sites in the transmembrane domains of GABAA receptor isoforms (Hosie et al., 2006), little information is available about the potential role of steroids in the modulation of the activity of membrane transporters. We now have identified a functional steroid-binding element in the membrane domain of ABCG2R482G, which shares sequence similarity with Helix 3 in hERα (Fig. 1). By analogy to the positioning of Helix 3 in the steroid-binding site of this receptor, the steroid-binding element in ABCG2R482G is likely to be part of a larger steroid binding pocket. The predicted location of the binding element at the external side of TMH 5 raises the possibility that the relatively large outer loop region connecting TMH 5 and TMH 6 contributes to the binding pocket.. The steroid interactions detected in our study seem to be steroid-specific. Whereas cholesterol and PG both stimulated ...
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Steroid definition, any of a large group of fat-soluble organic compounds, as the sterols, bile acids, and sex hormones, most of which have specific physiological action. See more.
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The long term objective of this project is a thorough understanding of how steroid hormone synthesis is regulated in a developmental and tissue-specific fashion, and how dysregulation may result in reproductive disorders such as polycystic ovarian syndrome (PCOS). The genes for steroidogenic enzymes are transcriptionally regulated at several levels: developmentally, tissue specifically, and hormonally. This regulation shares common features but also differs among the various genes for the steroidogenic enzymes and among various mammals. We will focus on the gene encoding P450c17 (17alpha hydroxylase/17,2 lyase) as it is the key branch point in steroidogenesis, it has been implicated in the etiology of PCOS, and it may be involved in early development of nervous and reproductive systems. Its expression in the human adrenal is required for the synthesis of 17 hydroxy C21 steroids (e.g. cortisol) and for synthesis of C19 sex steroids in the gonads and brain. In the nervous system, expression of ...
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The Federal Communications Commission (FCC) on Thursday approved the first database of all the unused wireless frequencies known as white spaces in the United States and has given the green light to the first hardware that will use them.. White space, or the wireless spectrum that was freed from the transition from analog to digital television, would be available to use without requiring a wireless license, similar to the way wi-fi works today. The problem, of course, is that the wireless frequencies that fall in this white space varies from market to market. This is why the database was required.. The database was collected by Spectrum Bridge Inc, who the FCC and Office of Engineering and Technology (OET) appointed in the beginning of 2011. With todays approval of the first TV white spaces database and device, we are taking an important step towards enabling a new wave of wireless innovation, FCC Chairman Julius Genachowski said in a statement on Thursday. Unleashing white spaces spectrum ...
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As pointed out in Tom Kirkendalls Weblog Houstons Clear Thinkers Mark Sisson, an athlete very much involved with the regulation of drug-testing in sports, has written a letter to Art DeVany on the subject. Sisson on Steroids . Although the ideas are interesting to consider, there are a number of problems. This is a difficult subject to discuss, not only because of the high emotional state it generates, but because of the shadowy nature of the entire network of athletes, trainers, and drug dealers. I will comment on some views from this letter Sisson on Steroids: 1. Sisson: Impossible to...
Hilton Worldwide is opening a new micro hotel concept described as a hostel on steroids.. In an effort to attract more Millennial-type travelers, Hilton is opening a new line of hotels that are smaller, cheaper and friendlier to the younger generation. CEO Christopher Nassetta told crowds at the Skift Global Forum that the new brand, which is yet unnamed, will be an "urban micro brand.". "Its very trendy in a sense, sort of like a hostel on steroids," Nassetta said. "But a lot of steroids." He later told Fortune that "the idea is to have super efficient spaces that are crazy flexible.". Hiltons brands continue to get physically smaller. In 2016, the company announced Tru by Hilton, smaller and cheaper properties than the companys standard flagship hotels. The goal with these smaller hotels is to compete with AirBNB, which gets a lot of millennial business.. The details still arent solid on Hiltons new micro-hotel brand, but the room size will be smaller than Trus rooms, measuring about 125 ...
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The drop in steroid hormone production was quite dramatic. After 120 hours in a medium that included 10 micrograms per milliliter of BPA, mouse follicle cells produced about 85 percent less estradiol, 97 percent less progesterone and 95 percent less testosterone. Lower doses of BPA had a less dramatic "" but still considerable "" dampening effect on steroid hormone levels. And at 120 hours, follicle cells grown in the BPA medium were 25 percent smaller than normal, the researchers report ...
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  • Anabolic steroids are primarily used by bodybuilders, athletes, and fitness 'buffs' who claim steroids give them a competitive advantage and/or improve their physical performance. (usdoj.gov)
  • Some people who are not athletes also take steroids to increase their endurance, muscle size and strength, and reduce body fat which they believe improves personal appearance. (usdoj.gov)
  • Athletes (middle or high school, college, professional, and Olympic) usually take steroids for a limited period of time to achieve a particular goal. (usdoj.gov)
  • Some bodybuilders and athletes use anabolic steroids to build muscles and improve athletic performance. (medlineplus.gov)
  • Confirmation/Argument Despite steroids having multiple negative effects on both athletes and the game of baseball, they also have good effects too. (bartleby.com)
  • The use of steroid by athletes has been a controversial issue for some time. (bartleby.com)
  • The steroids used by athletes are mostly androgenic steroids: steroids, which act like testosterone. (bartleby.com)
  • Dianabol (Methandrostenolone) is the most potent androgenic anabolic steroid that was heavily used by bodybuilders and athletes in the 80s-90s. (reddit.com)
  • The International Olympic Committee, National Collegiate Athletic Association and many professional sports leagues (including the Major League Baseball, National Basketball Association, National Football League, and National Hockey League), have banned the use of steroids by athletes due to their potentially dangerous side effects and because they give the user an unfair advantage. (conservapedia.com)
  • Doctors may prescribe steroids to patients for legitimate medical purposes such as loss of function of testicles, breast cancer, low red blood cell count, delayed puberty and debilitated states resulting from surgery or sickness. (usdoj.gov)
  • The resulting xanax of sodium target clinical information is prednisolone steroids menstrual cycle filtered and washed again with water until acetalized from medical expression. (peciatky.net)
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  • Others such as bodybuilders, law enforcement officers, fitness buffs, and body guards usually take steroids for extended periods of time. (usdoj.gov)
  • Kamano S (2000) Are steroids really ineffective for severely head injured patients? (springer.com)
  • The range of steroids is diverse, including several forms of vitamin D, digitalis, sterols (e.g., cholesterol ), and the bile acids. (factmonster.com)
  • Steroids can be given topically (cream or ointment), by mouth (orally), or by injection. (webmd.com)
  • Anabolic steroids are taken orally, injected intramuscularly, or rubbed on the skin when in the form of gels or creams. (conservapedia.com)
  • People who inject steroids also run the risk of contracting or transmitting hepatitis or HIV . (conservapedia.com)
  • The short-term adverse physical effects of anabolic steroid abuse are fairly well known. (usdoj.gov)
  • The long-term adverse physical effects of anabolic steroid abuse in men and in women, other than masculinizing effects, have not been studied, and as such, are not known. (usdoj.gov)
  • Because of the nature of the adverse effects of anabolic steroids, their use should be restricted to cases where the benefits clearly outweigh the risks. (encyclopedia.com)
  • Anabolic steroid abuse causes adverse side effects ranging from acne and breast development in men, to unattractive changes in appearance by women, to life-threatening conditions. (conservapedia.com)
  • Balancing your antennas' will help you to anabolic steroids and accutane feel better and to improve the skin of accutane for side. (posterprintshop.nl)
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  • Unlike anabolic steroids, Anadrole doesn't have the horrific side effects that you'd get with traditional steroids. (legalsteroids.best)
  • Steroids are strong medicines, and they can have side effects, including weakened bones and cataracts. (medlineplus.gov)
  • Steroids differ from one another in the structure of various side chains and additional rings. (factmonster.com)
  • There is increasing concern regarding possible serious health problems that are associated with the abuse of steroids, including both short-term and long-term side effects. (usdoj.gov)
  • The short-term side effects in men are reversible with discontinuation of steroid use. (usdoj.gov)
  • It's important to understand the facts about steroids, their side effects, and what can drive kids to try them. (healthfinder.gov)
  • This fact sheet focuses on teens and steroids, summarizing the side effects and risks associated with steroid use. (healthfinder.gov)
  • Steroids used in medical treatments can have some side effects, although they're not as extreme as the side effects from anabolic steroids. (kidshealth.org)
  • In addition, the risk of side effects is much higher with oral or IV steroids. (webmd.com)
  • Dr Brian Higgins, who is also a natural bodybuilder, has treated many steroids users who presented with side effects. (rte.ie)
  • It scares me that they will want to give you steroids at the drop of the hat and another med to counteract the side effects of them and that leads to another med to counteract those meds. (dailystrength.org)
  • Before receiving steroids for multiple sclerosis treatment, patients should be aware of the side effects and should arrange to be under the supervision of a physician. (dailystrength.org)
  • Concerns over a growing illicit market and prevalence of abuse combined with the possibility of harmful long-term effects of steroid use led Congress to place anabolic steroids into Schedule III of the Controlled Substances Act (CSA) in 1991. (conservapedia.com)
  • If you've been looking at alternatives to Illegal steroids, then you'll have likely stumbled across GNC and their huge range. (legalsteroids.best)
  • the most common illegal source is from smuggling steroids into the United States from other countries such as Mexico and European countries. (usdoj.gov)
  • If you have you must know that steroids are a deadly and illegal drug. (bartleby.com)
  • Over the past few months, different allegations toward certain superstars and their involvement with illegal anabolic steroids have surfaced. (bartleby.com)
  • The increase in the number of young people using illegal steroids is not being taken seriously enough in Ireland, according to experts. (rte.ie)
  • Agris Bremsmits supplied the researcher with a product called Sustannon, which contains a mixture of different steroids.Interviewed for RTÉ Investigates - Steroid Ireland, Dr Brendan Buckley, the former chair of the Irish Sports Council Anti-Doping Committee says, the use of illegal steroids by young people in Ireland is "a real issue with major health implications. (rte.ie)
  • RTÉ Investigates also uncovered a range of online sellers, fitness professionals and seemingly legitimate retail outlets engaged in the illegal sale and supply of steroids. (rte.ie)
  • Illegal anabolic steroids are often sold at gyms, competitions, and through mail operations after being smuggled into this country. (conservapedia.com)
  • The most common sources for obtaining steroids for illegal use are Internet purchases and smuggling them into the U.S. from other countries such as Mexico and European countries. (conservapedia.com)
  • It is therefore illegal to possess or sell anabolic steroids without a valid prescription. (conservapedia.com)
  • Some States have also implemented additional fines and penalties for illegal use of anabolic steroids. (conservapedia.com)
  • Anabolic steroids are synthetically produced variants of the naturally occurring male hormone testosterone. (usdoj.gov)
  • D-Bal, a healthy steroid alternative, contains all-natural ingredients, such as whey protein, BCAAs (branch-chained amino acids - leucine, valine, isoleucine), and Tribulus Terrestris, a plant known to naturally increase testosterone levels (despite modern researches show mixed conclusions). (reddit.com)
  • Anabolic steroids dispensed for legitimate medical purposes are administered several ways including intramuscular or subcutaneous injection, by mouth, pellet implantation under the skin and by application to the skin (e.g. gels or patches). (usdoj.gov)
  • These same routes are used for purposes of abusing steroids, with injection and oral administration being the most common. (usdoj.gov)
  • For example, in an otherwise healthy person, tendinitis may be adequately treated with only a steroid injection into the inflamed area. (webmd.com)
  • Steroids are used to treat certain diseases, but some people use them to enhance muscle mass and athletic performance. (healthfinder.gov)
  • Steroids can make you more fit for athletic competition and make the body more muscular which is considered appealing. (bartleby.com)
  • Your body makes less cortisol when you're having steroid treatments, so you need to ease off the medication and give your body a chance to get its own production back up to normal again. (kidshealth.org)
  • Anabolic steroids are compounds, derived from testosterone, which promote tissue growth and repair. (encyclopedia.com)
  • Steroids reduce the production of inflammatory chemicals in order to minimize tissue damage. (webmd.com)
  • Steroids are used to treat a variety of conditions in which the body's defense system malfunctions and causes tissue damage. (webmd.com)
  • Natural or synthetic steroids are used in oral contraceptives and in the treatment of arthritis , Addison's disease , and certain skin ailments. (factmonster.com)
  • Anabolic steroids are synthetic (man-made) versions of testosterone. (medlineplus.gov)
  • Anabolic steroids are a group molecules that include the male sex hormone testosterone and synthetic analogs of testosterone" (Taylor,1991) Anabolic steroids are used by many people in sports today due to the rapid increase in muscle mass. (bartleby.com)
  • Deca-Durabolin is a strong anabolic steroid administered by doctors to treat severe diseases, such as anemia. (reddit.com)
  • If there's an emergency, the card or bracelet will let doctors know you're being treated with steroids - or have been recently, which can change the treatment they need to give you. (kidshealth.org)
  • Injecting steroids into one or two areas of inflammation allows doctors to deliver a high dose of the drug directly to the problem area. (webmd.com)
  • When doctors give steroids by mouth or IV, they cannot be sure an adequate amount will eventually reach the problem area. (webmd.com)
  • study up on steroids for MS and see if the damage they can cause to your body is worth the 'quick fix' the doctors tell you about. (dailystrength.org)
  • In humans, steroids are secreted by the ovaries and testes, the adrenal cortex (see adrenal gland ), and the placenta. (factmonster.com)
  • It contains plant extracts including Samento and Sitosterol (part of the same steroid chemical family), plus it also manages to pack in a small amount of pepsin, a vital enzyme that exists to help your body digest protein. (legalsteroids.best)
  • Steroids are a very large class of compounds, which occur in all animalsalso. (bartleby.com)
  • Steroids work by decreasing inflammation and reducing the activity of the immune system. (webmd.com)
  • Steroids decrease inflammation and reduce the activity of the immune system. (webmd.com)
  • Steroids are used as the main treatment for certain inflammatory conditions, such as systemic vasculitis (inflammation of blood vessels) and myositis (inflammation of muscle). (webmd.com)
  • When inflammation threatens to damage critical body organs, steroids can be organ saving and, in many instances, life-saving. (webmd.com)
  • Until the year 1935 scientists never knew that testosterone steroids were associated with an increase in muscle production. (bartleby.com)
  • Steroids Testosterone was often referred to as the "male hormone", It is responsible for the development of the male characteristics such as lowering of the voice, hair growth, and because the male body produces much more of it than the female. (bartleby.com)
  • An eight-month undercover investigation reveals how young people craving a perfect body image are being sold potentially dangerous anabolic steroids by personal trainers, bouncers and retailers. (rte.ie)
  • Yes, the friends on the people of discount are propecia after steroids occult and only, and that creates hair for us consistently. (kalentura.com)
  • Why do people abuse steroids? (usdoj.gov)
  • But some people misuse anabolic steroids. (medlineplus.gov)
  • Why do people misuse anabolic steroids? (medlineplus.gov)
  • Steroids, what they are why people use them What are anabolic steroids? (bartleby.com)
  • Many people see Steroids as an answer to their problems. (bartleby.com)
  • Many people turn to steroids because they think it will give them solutions to the problems they have with society. (bartleby.com)
  • For these people, steroid therapy may eliminate the need for kidney dialysis or transplant. (webmd.com)
  • Some people report relief from osteoarthritis when steroids are injected directly into swollen or painful joints. (webmd.com)
  • A recent survey found that one in five young people in Ireland would consider taking steroids, which are now cheaper and more accessible than ever before. (rte.ie)
  • Being a doctor I've seen firsthand people using steroids. (rte.ie)
  • I've never used steroids and it's very important to me for people to know I am anti-steroids. (rte.ie)
  • But what is so important is that young people are educated about steroids," Dr Higgins added. (rte.ie)
  • Sometimes, your doctor will recommend steroid treatments just to help you sleep, eat, and feel better. (kidshealth.org)
  • Are you looking for safe, natural, and effective steroid alternatives that really work? (reddit.com)
  • 17.1% of eighth graders, 30.2% of tenth graders, and 41.1% of twelfth graders surveyed in 2006 reported that steroids were "fairly easy" or "very easy" to obtain. (conservapedia.com)
  • Steroids also reduce the activity of the immune system by affecting the function of white blood cells . (webmd.com)
  • Steroids don't pump up your immune system. (dailystrength.org)