Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
The plan and delineation of prostheses in general or a specific prosthesis.
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
A mixture of metallic elements or compounds with other metallic or metalloid elements in varying proportions.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Narrowing or constriction of a coronary artery.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
The veins and arteries of the HEART.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Formation and development of a thrombus or blood clot in the blood vessel.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
Obstruction of flow in biological or prosthetic vascular grafts.
Stainless steel. A steel containing Ni, Cr, or both. It does not tarnish on exposure and is used in corrosive environments. (Grant & Hack's Chemical Dictionary, 5th ed)
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
The condition of an anatomical structure's being constricted beyond normal dimensions.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Elements of limited time intervals, contributing to particular results or situations.
Methods of creating machines and devices.
The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The degree to which BLOOD VESSELS are not blocked or obstructed.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
A stricture of the ESOPHAGUS. Most are acquired but can be congenital.
The return of a sign, symptom, or disease after a remission.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Migration of a foreign body from its original location to some other location in the body.
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Surgical insertion of a prosthesis.
Failure of equipment to perform to standard. The failure may be due to defects or improper use.
Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
The hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Removal of an implanted therapeutic or prosthetic device.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
The main artery of the thigh, a continuation of the external iliac artery.
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
Radiography of blood vessels after injection of a contrast medium.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Chronic inflammation and granuloma formation around irritating foreign bodies.
Introduction of a tube into a hollow organ to restore or maintain patency if obstructed. It is differentiated from CATHETERIZATION in that the insertion of a catheter is usually performed for the introducing or withdrawing of fluids from the body.
Pathological processes involving the URETERS.
Endoscopic examination, therapy or surgery performed on the interior of blood vessels.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Conditional probability of exposure to a treatment given observed covariates.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.
Organic polymeric materials which can be broken down by naturally occurring processes. This includes plastics created from bio-based or petrochemical-based materials.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.
One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.
Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.
The vein which drains the foot and leg.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.
A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.
Radiography of the vascular system of the brain after injection of a contrast medium.
Percutaneous transluminal procedure for removing atheromatous plaque from the coronary arteries. Both directional (for removing focal atheromas) and rotational (for removing concentric atheromatous plaque) atherectomy devices have been used.
Tantalum. A rare metallic element, atomic number 73, atomic weight 180.948, symbol Ta. It is a noncorrosive and malleable metal that has been used for plates or disks to replace cranial defects, for wire sutures, and for making prosthetic devices. (Dorland, 28th ed)
Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.

PlA polymorphism of platelet glycoprotein IIIa and risk of restenosis after coronary stent placement. (1/7427)

BACKGROUND: Platelets play a central role in the process of restenosis after percutaneous coronary interventions. A polymorphism of platelet glycoprotein IIIa (PlA) has been associated with a higher risk of coronary thrombosis. We designed this prospective study to test the hypothesis that PlA polymorphism of glycoprotein IIIa is associated with an increased risk for restenosis after coronary stent placement. METHODS AND RESULTS: The study included 1150 consecutive patients with successful coronary stent placement and 6-month follow-up with coronary angiography. The end point of the study was the incidence of angiographic restenosis (>/=50% diameter stenosis) at follow-up. Of the 1150 patients, 72.5% were homozygous for PlA1, 24.7% were heterozygous (PlA1/A2), and 2.8% were homozygous for PlA2. Patients with the PlA2 allele demonstrated a significantly higher restenosis rate than did those without (47% versus 38%; OR, 1.42; 95% CI, 1.09 to 1.84). The risk was highest in homozygous carriers of PlA2 (53.1% restenosis rate). After adjustment for several clinical and angiographic characteristics, the presence of the PlA2 allele remained a significantly independent risk factor for restenosis (adjusted OR, 1.35; 95% CI, 1.07 to 1.70). The influence of the PlA2 allele on restenosis was stronger in women. Women with PlA2 had a restenosis rate of 52% compared with the 33% incidence among women homozygous for PlA1 (OR, 2.21; 95% CI, 1.27 to 3.85). CONCLUSIONS: This study showed a significant association between the PlA polymorphism of glycoprotein IIIa and the risk of restenosis after coronary stent placement. The risk was more pronounced in patients homozygous for PlA2 allele and in female patients.  (+info)

In-stent neointimal proliferation correlates with the amount of residual plaque burden outside the stent: an intravascular ultrasound study. (2/7427)

BACKGROUND: The aim of this study was to evaluate the relationship between residual plaque burden after coronary stent implantation and the development of late in-stent neointimal proliferation. METHODS AND RESULTS: Between January 1996 and May 1997, 50 patients underwent intravascular ultrasound (IVUS) interrogation at 6+/-1.2 months after coronary stent implantation in native coronary arteries. IVUS images were acquired with a motorized pullback, and cross-sectional measurements were performed within the stents at 1-mm intervals. The following measurements were obtained: (1) lumen area (LA), (2) stent area (SA), (3) area delimited by the external elastic membrane (EEMA), (4) percent neointimal area calculated as (SA-LA/SA)x100, and (5) percent residual plaque area calculated as (EEMA-SA)/EEMAx100. Volume measurements within the stented segments were calculated by applying Simpson's rule. In the pooled data analysis of 876 cross sections, linear regression showed a significant positive correlation between percent residual plaque area and percent neointimal area (r=0.50, y= 45.03+0.29x, P<0.01). There was significant incremental increase in mean percent neointimal area for stepwise increase in percent residual plaque area. Mean percent neointimal area was 16.3+/-10.3% for lesions with a percent residual plaque area of <50% and 27.7+/-11% for lesions with a percent residual plaque area of >/=50% (P<0.001). The volumetric analysis showed that the percent residual plaque volume was significantly greater in restenotic lesions compared with nonrestenotic lesions (58.7+/-4.3% versus 51.4+/-5.7%, respectively; P<0.01). CONCLUSIONS: Late in-stent neointimal proliferation has a direct correlation with the amount of residual plaque burden after coronary stent implantation, supporting the hypothesis that plaque removal before stent implantation may reduce restenosis.  (+info)

Comparison of quantitative coronary angiography, intravascular ultrasound, and coronary pressure measurement to assess optimum stent deployment. (3/7427)

BACKGROUND: Although intravascular ultrasound (IVUS) is the present standard for the evaluation of optimum stent deployment, this technique is expensive and not routinely feasible in most catheterization laboratories. Coronary pressure-derived myocardial fractional flow reserve (FFRmyo) is an easy, cheap, and rapidly obtainable index that is specific for the conductance of the epicardial coronary artery. In this study, we investigated the usefulness of coronary pressure measurement to predict optimum and suboptimum stent deployment. METHODS AND RESULTS: In 30 patients, a Wiktor-i stent was implanted at different inflation pressures, starting at 6 atm and increasing step by step to 8, 10, 12, and 14 atm, if necessary. After every step, stent deployment was evaluated by quantitative coronary angiography (QCA), IVUS, and coronary pressure measurement. If any of the 3 techniques did not yield an optimum result, the next inflation was performed, and all 3 investigational modalities were repeated until optimum stent deployment was present by all of them or until the treating physician decided to accept the result. Optimum deployment according to QCA was finally achieved in 24 patients, according to IVUS in 17 patients, and also according to coronary pressure measurement in 17 patients. During the step-up, a total of 81 paired IVUS and coronary pressure measurements were performed, of which 91% yielded concordant results (ie, either an optimum or a suboptimum expansion of the stent by both techniques, P<0.00001). On the contrary, QCA showed a low concordance rate with IVUS and FFRmyo (48% and 46%, respectively). CONCLUSIONS: In this study, using a coil stent, both IVUS and coronary pressure measurement were of similar value with respect to the assessment of optimum stent deployment. Therefore, coronary pressure measurement can be used as a cheap and rapid alternative to IVUS for that purpose.  (+info)

The endovascular management of blue finger syndrome. (4/7427)

OBJECTIVES: To review our experience of the endovascular management of upper limb embolisation secondary to an ipsilateral proximal arterial lesion. DESIGN: A retrospective study. MATERIALS AND METHODS: Over 3 years, 17 patients presented with blue fingers secondary to an ipsilateral proximal vascular lesion. These have been managed using transluminal angioplasty (14) and arterial stenting (five), combined with embolectomy (two) and anticoagulation (three)/anti-platelet therapy (14). RESULTS: All the patients were treated successfully. There have been no further symptomatic embolic episodes originating from any of the treated lesions, and no surgical amputations. Complications were associated with the use of brachial arteriotomy for vascular access. CONCLUSIONS: Endovascular techniques are safe and effective in the management of upper limb embolic phenomena associated with an ipsilateral proximal focal vascular lesion.  (+info)

Balloon-artery interactions during stent placement: a finite element analysis approach to pressure, compliance, and stent design as contributors to vascular injury. (5/7427)

Endovascular stents expand the arterial lumen more than balloon angioplasty and reduce rates of restenosis after coronary angioplasty in selected patients. Understanding the factors involved in vascular injury imposed during stent deployment may allow optimization of stent design and stent-placement protocols so as to limit vascular injury and perhaps reduce restenosis. Addressing the hypothesis that a previously undescribed mechanism of vascular injury during stent deployment is balloon-artery interaction, we have used finite element analysis to model how balloon-artery contact stress and area depend on stent-strut geometry, balloon compliance, and inflation pressure. We also examined superficial injury during deployment of stents of varied design in vivo and in a phantom model ex vivo to show that balloon-induced damage can be modulated by altering stent design. Our results show that higher inflation pressures, wider stent-strut openings, and more compliant balloon materials cause markedly larger surface-contact areas and contact stresses between stent struts. Appreciating that the contact stress and contact area are functions of placement pressure, stent geometry, and balloon compliance may help direct development of novel stent designs and stent-deployment protocols so as to minimize vascular injury during stenting and perhaps to optimize long-term outcomes.  (+info)

Surgical transluminal iliac angioplasty with selective stenting: long-term results assessed by means of duplex scanning. (6/7427)

PURPOSE: The safety of iliac angioplasty and selective stenting performed in the operating room by vascular surgeons was evaluated, and the short- and long-term results were assessed by means of serial duplex scanning. METHODS: Between 1989 and 1996, 281 iliac stenotic or occlusive lesions in 235 consecutive patients with chronic limb ischemia were treated by means of percutaneous transluminal angioplasty (PTA) alone (n = 214) or PTA with stent (n = 67, 23.8%). There were 260 primary lesions and 21 restenosis after a first PTA, which were analyzed separately. Stents were implanted in selected cases, either primarily in totally occluded arteries or after suboptimum results of PTA (ie, residual stenosis or a dissection). Data were collected prospectively and analyzed retrospectively. Results were reported in an intention-to-treat basis. Clinical results and patency were evaluated by means of symptom assessment, ankle brachial pressure index, and duplex scanning at discharge and 1, 3, 6, and every 12 months after angioplasty. To identify factors that may affect outcome, 12 clinical and radiological variables, including the four categories of lesions defined by the Standards of Practice Committee of the Society of Cardiovascular and Interventional Radiology, were analyzed separately. The statistical significances of life-table analysis of patency were determined by means of the log-rank test. RESULTS: There were no postoperative deaths or amputations. Local, general, and vascular complications occurred in 2.1%, 1.3% and 4.7% of cases, respectively (total, 8.1%). The mean follow-up period was 29.6 months. The cumulative patency rates +/- SE of the 260 PTAs (including 55 PTAs plus stents) were 92.9% +/- 1.5% at 1 month, 86. 5% +/- 1.7% at 1 year, 81.2% +/- 2.3% at 2 years, 78.8% +/- 2.9% at 3 years, and 75.4% +/- 3.5% at 5 and 6 years. The two-year patency rate of 21 redo PTAs (including 11 PTAs plus stents) was 79.1% +/- 18.2%. Of 12 predictable variables studied in the first PTA group, only the category of the lesion was predictive of long-term patency. The two-year patency rate was 84% +/- 3% for 199 category 1 lesions and 69.7% +/- 6.5% for 61 category 2, 3, and 4 lesions together (P =. 02). There was no difference of patency in the stented and nonstented group. CONCLUSION: Iliac PTA alone or with the use of a stent (in cases of occlusion and/or suboptimal results of PTA) offers an excellent long-term patency rate. Categorization of lesions remains useful in predicting long-term outcome. PTA can be performed safely by vascular surgeons in the operating room and should be considered to be the primary treatment for localized iliac occlusive disease.  (+info)

Relief of obstructive pelvic venous symptoms with endoluminal stenting. (7/7427)

PURPOSE: To select patients for percutaneous transluminal stenting of chronic postthrombotic pelvic venous obstructions (CPPVO), we evaluated the clinical symptoms in a cohort of candidates and in a series of successfully treated patients. METHODS: The symptoms of 42 patients (39 women) with CPPVO (38 left iliac; average history, 18 years) were recorded, and the venous anatomy was studied by means of duplex scanning, subtraction venography, and computed tomography or magnetic resonance imaging. Successfully stented patients were controlled by means of duplex scanning and assessment of symptoms. RESULTS: The typical symptoms of CPPVO were reported spontaneously by 24% of patients and uncovered by means of a targeted interview in an additional 47%. Of 42 patients, 15 had venous claudication, four had neurogenic claudication (caused by dilated veins in the spinal canal that arise from the collateral circulation), and 11 had both symptoms. Twelve patients had no specific symptoms. Placement of a stent was found to be technically feasible in 25 patients (60%), was attempted in 14 patients, and was primarily successful in 12 patients. One stent occluded within the first week. All other stents were fully patent after a mean of 15 months (range, 1 to 43 months). Satisfaction was high in the patients who had the typical symptoms, but low in those who lacked them. CONCLUSION: Venous claudication and neurogenic claudication caused by venous collaterals in the spinal canal are typical clinical features of CPPVO. We recommend searching for these symptoms, because recanalization by means of stenting is often feasible and rewarding.  (+info)

Endovascular repair of a descending thoracic aortic aneurysm: a tip for systemic pressure reduction. (8/7427)

A proposed technique for systemic pressure reduction during deployment of a stent graft was studied. A 67-year-old man, who had a descending thoracic aneurysm, was successfully treated with an endovascular procedure. An occluding balloon was introduced into the inferior vena cava (IVC) through the femoral vein. The balloon volume was manipulated with carbon dioxide gas to reduce the venous return, resulting in a transient and well-controlled hypotension. This IVC-occluding technique for systemic pressure reduction may be safe and convenient to minimize distal migration of stent grafts.  (+info)

EU5 Non-Vascular Stents Market Outlook to 2020 is a new market research publication announced by Reportstack. This report provides key market data on the EU5 Non-Vascular Stents market. The report provides value, in millions of US dollars, volume (in units) and average prices (in US dollars) within market segments - Biliary Stents (Plastic Biliary Stents and Metal Biliary Stents (Metal Non-Covered Biliary Stents, Metal Partially Covered Biliary Stents and Metal Fully Covered Biliary Stents)), Gastrointestinal Stents (Fully Covered, Partially Covered and Non-Covered Gastrointestinal Stents), Airway Stents (Silicone Airway Stents and Metallic Airway Stents (Fully Covered and Uncovered Metallic Airway Stents) and Urinary Tract Stents ((Ureteral Stents (Metal, Polymer and Bioabsorbable Ureteral Stents), Prostate Stents (Metal, Polymer and Bioabsorbable Prostate Stents) and Urethral Stents (Metal, Polymer and Bioabsorbable Urethral Stents ...
View details of top carotid artery stent placement hospitals in Thane. Get guidance from medical experts to select best carotid artery stent placement hospital in Thane
Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. Clinical data,operative success rate,locations of coronary artery lesions,number of implanted stents,clinical outcome,hospitalization related expenses and incidence of complications were compared between the two groups. Results Patients of the two groups completed the operation successfully,the operative success rates of the two
TY - JOUR. T1 - Frequency of Slow Coronary Flow Following Successful Stent Implantation and Effect of Nitroprusside. AU - Airoldi, Flavio. AU - Briguori, Carlo. AU - Cianflone, Domenico. AU - Cosgrave, John. AU - Stankovic, Goran. AU - Godino, Cosmo. AU - Carlino, Mauro. AU - Chieffo, Alaide. AU - Montorfano, Matteo. AU - Mussardo, Marco. AU - Michev, Iassen. AU - Colombo, Antonio. AU - Maseri, Attilio. PY - 2007/4/1. Y1 - 2007/4/1. N2 - Nitroprusside (NTP) is used for the treatment of slow coronary flow (SCF) after coronary interventions. The wide variation in dosage, route, and timing of its administration in the reported studies prevents an objective assessment of its efficacy. We report the incidence and response to a standardized NTP protocol of SCF after successful stent implantation. Selective intracoronary administration of incremental doses (initial bolus of 80 μg incremented by 40 μg) of NPT was assessed in 21 patients who developed SCF in a series of 2,212 consecutive patients who ...
Self-Expandable Stents in the Gastrointestinal Tract Health Beauty Health Care Medicine Drugs OTC Drugs Treatments Description:Self-expandable stents were initially placed for the treatment of cardiovascular diseases but now play an integral role in the relief of benign and malignant obstruction of the gastrointestinal tract and biliary system. Self-Expandable Stents in the Gastrointestinal Tract
From Cardiology Team, Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong. LAM and LI: Use of Distal Protection Device for Percutaneous Intervention in Native Coronary Arteries. Microembolization of particulate debris during percutaneous coronary intervention (PCI) will lead to various degree of microvascular obstruction, terminating in no-reflow phenomenon observed angiographically. Different methods, including angiography, non-invasive imaging, and assays of myocardial injury markers, have been used for detection of occurrence of microvascular obstruction. The prevalence of, and the adverse prognosis associated with microvascular obstruction have led to the concept and application of distal protection for coronary interventions. While its value has been confirmed in saphenous vein grafts intervention, data is now growing to support use of distal protection devices in native coronaries. Findings from a local registry that reveals the initial experience on use of ...
The Coronary Stents Market market report provides an overview of Coronary Stents Market, as well as its PEST Analysis. Additionally, the report provides insight on the Coronary Stents Market market share of the individual Coronary Stents Market devices, current and forecasted Coronary Stents Market market size from 2018 to 2026 segmented by seven major markets. The report also covers the market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.. Coronary Stents Overview. Coronary stents are strechable devices that are used to expand the arteries in patients that can further stop the blockage caused in the arteries. Some patients suffer from coronary diseases due to the build-up of plaque in arteries. Therefore, coronary stents can be used in expanding the narrowed arteries, exempting any chance of heart attack or other coronary disorders within patients.. Request free sample copy- ...
Airway self-expandable metallic stents (SEMS) were initially studied in malignant airway obstruction; however, their use in benign airway diseases has become progressively more frequent. This may be explained by their ease of insertion compared with silicone stents, which require rigid bronchoscopy for insertion. While initial experience with SEMS in benign disease suggested efficacy and promising short-term safety profile, long-term follow-up revealed significant complication rates. In addition to a high complication rate, the management of these complications is made more difficult by the semipermanent nature of these devices. Reported complications include infection, granulation tissue formation, stent migration, stent fracture, airway perforation and fistula formation, as well as extension of the initial injury, potentially eliminating other therapeutic options such as surgical resection. Therefore, SEMS should only be used in nonmalignant large airway disease as a last resort for patients in whom
1 Table of Contents. 1 Table of Contents 2. 1.1 List of Tables 4. 1.2 List of Figures 4. 2 Introduction 5. 2.1 What Is This Report About? 5. 2.2 Non-Vascular Stents Market Segmentation 5. 2.3 Definitions of Markets Covered in the Report 6. 3 Non-Vascular Stents Market, India 8. 3.1 Non-Vascular Stents Market, India, Revenue ($m), 2009-2016 8. 3.2 Non-Vascular Stents Market, India, Revenue ($m), 2016-2023 10. 3.2.1 Airway Stents Market, India, Revenue ($m), by Segment, 2009-2016 12. 3.2.2 Enteral Stents Market, India, Revenue ($m), by Segment, 2009-2016 14. 3.2.3 Pancreatic and Biliary Stents Market, India, Revenue ($m), by Segment, 2009-2016 16. 3.2.4 Urinary Tract Stents Market, India, Revenue ($m), by Segment, 2009-2016 18. 3.2.5 Airway Stents Market, India, Revenue ($m), by Segment, 2016-2023 20. 3.2.6 Enteral Stents Market, India, Revenue ($m), by Segment, 2016-2023 22. 3.2.7 Pancreatic and Biliary Stents Market, India, Revenue ($m), by Segment, 2016-2023 24. 3.2.8 Urinary Tract Stents ...
The FAIR trials objective was to assess safety and efficacy of angioplasty with drug-eluting balloon vs. standard angioplasty for the treatment of symptomatic superficial femoral artery in-stent restenosis. The primary endpoint was binary (≥50%) restenosis rate at six months as assessed by duplex ultrasound corelab adjudication (PSVR≥2.4). The secondary endpoints were primary angiographic success (,50% residual stenosis), six-month recurrent in-stent restenosis (≥70%) and 12-month recurrent in-stent restenosis (≥50%), six- and 12-month clinically-driven target lesion revascularisation, and clinical/haemodynamic assessment (walking distance, ankle brachial index, Rutherford category) at one, six and 12 months. The investigators also assessed the major adverse vascular events (MAVE) at 12 months.. Patients who had Rutherford class 2-4 lesions and superficial femoral artery in-stent restenosis between 70-100% as assessed by duplex ultrasound were included. Further, to be included, patients ...
Stents are used in the treatment of numerous biliary tract diseases, ranging from benign biliary diseases to malignant strictures. Two types of biliary stents find extensive use: plastic Amsterdam-type stents and self-expanding metallic stents. The more commonly used Amsterdam-type plastic stents are tubular structures with diameters ranging from 7 to 12 Fr. Further increase in the diameter of plastic stents is precluded by the working channel diameter of side-viewing endoscopes. The major limitation of these plastic stents is their limited patency (with an average time of failure of 82.7±5 days). The primary reason for failure is complete obstruction of bile flow due to occlusion by biofilm and biliary sludge.1 The obstruction rate was found to be 27% in the first 30 days of plastic stent deployment.2 The risk of occlusion increases progressively after 3 months with a median patency of 4-5 months.3 Nevertheless, plastic stents are widely used because of their low cost and their ease of removal ...
A coronary stent is a tubular structured device made of a thin mesh of wire, which may also be coated with a polymer containing a drug, or made of biodegradable materials. Coronary stents are utilized during percutaneous coronary interventions (PCIs) for the treatment of patients suffering from various coronary artery diseases (CADs) such as acute myocardial infarction, angina pectoris and others. At present, several researches are being conducted in the field of coronary stenting, in order to minimize side effects such as restenosis and thrombosis. Certain new and advanced coronary stents such as bio-absorbable stents have been commercialized in the global market, which demonstrate very less or no common side effects of coronary stenting.. Request a Sample Copy of the Report @ The market for coronary stents can be broadly classified into three major segments, namely, bare metal stents (BMS), drug eluting stents (DES) and bio-absorbable stents. In 2011, the drug ...
BRIC Enteral Stent Procedures Outlook to 2025 - Enteral stenting Procedures using Fully Covered Enteral stents, Enteral stenting Procedures using Non-Covered Enteral stents and Enteral stenting Procedures using Partially Covered Enteral stents
OBJECTIVE. The purpose of this prospective study was to evaluate the efficacy of expandable metal stents for colonic decompression in patients presenting with acute malignant obstruction and to describe the associated radiographic findings. SUBJECTS AND METHODS. Using both fluoroscopic and endoscopic guidance, we placed expandable metal stents within the colons of 13 patients presenting with acute malignant obstruction. Stents were placed in four patients to permit a standard bowel cleansing before surgical resection with primary anastomosis. In the other nine patients, stents were placed for palliation of nonresectable tumors, obviating colostomy. Outcomes and complications were analyzed. The radiologic aspects of procedural planning, stent placement, assessment after placement, and detection of complications were evaluated. RESULTS. Of the four surgical candidates who were successfully resected with primary anastomosis, two received incomplete bowel cleansing because of stent migration with ...
Since the drug eluting stents have provided better results concerning restenosis and repeat revascularization comparing to bare metal stents, percutaneous coronary interventions are performing increasingly in more complex stenoses. However, drug eluting stents did not show any advantage on prevention of myocardial infarction and survival. Currently there is no any completed controlled randomized study showing the superiority or equality of drug eluting stents over coronary bypass surgery by means of efficacy and safety. While the long-term results of drug eluting stents still unclear, everyday progressively more patients with multivessel disease are undergoing percutaneous coronary intervention with drug eluting stent implantation. The aim of this review is to discuss the efficacy and safety of drug eluting stents in patients with multivessel disease.. Keywords: Coronary artery disease, stent, drug-eluting stent, multivessel disease, coronary bypass ...
TY - JOUR. T1 - Chronic Arterial Responses to Polymer-Controlled Paclitaxel-Eluting Stents. T2 - Comparison with Bare Metal Stents by Serial Intravascular Ultrasound Analyses: Data from the Randomized TAXUS-II Trial. AU - Tanabe, Kengo. AU - Serruys, Patrick W.. AU - Degertekin, Muzaffer. AU - Guagliumi, Giulio. AU - Grube, Eberhard. AU - Chan, Charles. AU - Munzel, Thomas. AU - Belardi, Jorge. AU - Ruzyllo, Witold. AU - Bilodeau, Luc. AU - Kelbaek, Henning. AU - Ormiston, John. AU - Dawkins, Keith. AU - Roy, Louis. AU - Strauss, Bradley H.. AU - Disco, Clemens. AU - Koglin, Jörg. AU - Russell, Mary E.. AU - Colombo, Antonio. PY - 2004/1/20. Y1 - 2004/1/20. N2 - Background-Polymer-controlled paclitaxel-eluting stents have shown a pronounced reduction in neointimal hyperplasia compared with bare metal stents (BMS). The aim of this substudy was to evaluate local arterial responses through the use of serial quantitative intravascular ultrasound (IVUS) analyses in the TAXUS II trial. Methods and ...
At present, the product information of intracoronary stents provided by the industry contains only limited technical data restricting judgments on the in vivo performance of individual products. Available experimental and clinical evidence suggests that interventional target sites display highly heterogeneous biomechanical behavior needed to be matched by specific stent and stent delivery system characteristics. To allow individualized stent-lesion matching, both, understanding of biomechanical properties of the atherosclerotic coronary artery lesions and expert knowledge of the intracoronary stent systems, are required. Here, the authors review some of the initial data on mechanical properties of coronary artery lesions potentially relevant to stenting and suggest standards for technical documentation of intracoronary stents.. ...
Japan Urinary Tract Stent Procedures Outlook to 2025 - Prostate Stenting Procedures, Ureteral Stenting Procedures and Urethral Stenting Procedures
A trend which will definitely change the market is the emergence of bio-absorbable stents. Since 1995, the introduction of new products such as bio-absorbable scaffolds, biodegradable polymers, and bifurcation stents is likely to increase the use of vascular stents in interventional cardiology. These stents have the potential to eliminate the complications of durable polymer stents. This will induce a significant positive shift in the treatment of artery stenosis and encourage affected individuals to undergo vascular stenting. Bio-absorbable stents restore blood flow by opening the clogged blood vessel and provide support until the damaged blood vessel heals. Unlike metallic stents, the body gradually metabolizes the bio-absorbable stent and entirely absorbs them over time.. Ask Sample PDF of Vascular Stents Market Report @ According to the Vascular Stents Market report, a key growth driver is the demand for minimally invasive ...
Cerebral embolization during carotid artery stenting (CAS) can often precipitate severe adverse neurological effects. Most major clinical studies of CAS have used distal filters for cerebral protection and have compared the neurologic complication rates with those of carotid endarterectomy (CEA). Many currently available embolic protection devices, however, have limited efficacy in capturing microembolic debris that is liberated during stenting, pre-dilatation and post-dilatation. Distal protection systems are furthermore limited by the need to cross the lesion prior to deployment. Some studies have shown a relatively high incidence of cerebral infarction even when distal protection devices are employed.. Cerebral protection with carotid flow reversal is a method that was developed as an alternative to the use of distal protection devices. While novel in its approach, this method too has its limitations. Another technique developed employs carotid flow reversal prior to traversing the stenosis ...
Cerebral embolization during carotid artery stenting (CAS) can often precipitate severe adverse neurological effects. Most major clinical studies of CAS have used distal filters for cerebral protection and have compared the neurologic complication rates with those of carotid endarterectomy (CEA). Many currently available embolic protection devices, however, have limited efficacy in capturing microembolic debris that is liberated during stenting, pre-dilatation and post-dilatation. Distal protection systems are furthermore limited by the need to cross the lesion prior to deployment. Some studies have shown a relatively high incidence of cerebral infarction even when distal protection devices are employed.. Cerebral protection with carotid flow reversal is a method that was developed as an alternative to the use of distal protection devices. While novel in its approach, this method too has its limitations. Another technique developed employs carotid flow reversal prior to traversing the stenosis ...
Global Drug-Eluting Stents Market 2025 Report Provides Porters Five Forces Analysis Illustrates the Potency of Buyers & Suppliers Operating in the Industry & the Quantitative Analysis of The Global Market from 2019 to 2025 is Provided to Determine the Market Potential.. Drug eluting stents are tubular mesh-like structures of thin wires that are placed inside coronary arteries during percutaneous coronary interventions (PCIs) to help treat acute myocardial infarction, atherosclerosis, angina pectoris, and other coronary disorders. Presently, a wide range of stents are available in the global drug eluting stents market due to technological advancements leading to their incorporation into stenting technologies. Drug eluting stents are made of metal coated with a pharmacologic agent, which is known to suppress restenosis. These stents have proven to be efficient in the treatment of acute myocardial infraction, angina pectoris, multiple vessel disease, and atherosclerosis. Drug eluting stents have ...
TY - JOUR. T1 - Platelet function and total length of intracoronary stents. T2 - Is there a correlation? [2]. AU - Cummings, Charles C.. AU - McKenzie, Marcus E.. AU - Horowitz, Eric D.. AU - Oshrine, Benjamin R.. AU - Callahan, Kevin P.. AU - Gurbel, Paul A.. AU - Serebruany, Victor L.. PY - 2001/1/15. Y1 - 2001/1/15. KW - Aggregometry. KW - Coronary artery disease. KW - Glycoprotein IIb/IIIa. KW - Intracoronary stents. KW - Platelets. UR - UR - U2 - 10.1016/S0049-3848(00)00372-8. DO - 10.1016/S0049-3848(00)00372-8. M3 - Letter. C2 - 11392314. AN - SCOPUS:0035862597. VL - 101. SP - 105. EP - 107. JO - Thrombosis Research. JF - Thrombosis Research. SN - 0049-3848. IS - 2. ER - ...
Hello and welcome to the December issue of Vascular Disease Management. I have chosen to comment on Deepika Kalisetta and colleagues case report on Balloon Assisted Dislodgement of a Trapped Directional Atherectomy Catheter (the Ocelot device) During Treatment of In-Stent Restenosis (ISR).. Stenting of femoropopliteal arterial obstructive lesions has been demonstrated to result in higher primary patency than standard balloon angioplasty. Stenting is also routinely utilized to treat flow-limiting dissections following PTA and atherectomy. Therefore, stenting is commonly utilized in treating symptomatic femoral and popliteal arterial obstructions. Unfortunately, restenosis and reocclusion are common following stenting. Whereas stent grafts tend to develop recurrent stenosis only at the edge of the stents, standard nitinol self-expanding stents often develop diffuse in-stent restenosis secondary to neointimal hyperplasia and reocclusion when there is superimposed thrombus. Stent restenosis can ...
Unlike the BENESTENT I and STRESS trials, which showed a 30% reduction in late restenosis with the use of stents, angiographic restenosis in OCBAS was similar between PTCA and stented patients, as was length of hospital stay, TVR and freedom from major cardiac events. Despite the lack of benefit observed, overall costs were significantly higher in the stent than in the optimal PTCA with provisional stenting group. Despite a small sample size, the OCBAS trial suggests immediate use of coronary stents following optimal PTCA may not be warranted, but rather a delayed, conservative approach may result in similar outcomes. Given the conflicting results with trials such as DEBATE II, which showed higher costs with provisional stenting, further trials are needed before a definitive conclusion can be drawn. Finally, waiting 30 minutes to examine the early loss may not be feasible in clinical practice, and the trial was initiated before the availability of later generations of stents and does not include ...
Press Release issued Oct 5, 2017: Non-vascular stents are specialized medical devices used for relieving the strictures in gastrointestinal tract, ureteral tract and airway tracts. These are also used for holding open the narrowed lumens during complex surgical procedure to allow free flow of body fluids. On the basis of its applications there are three different types of non-vascular stents are available: pulmonology stents, urology stents, and gastroenterology stents. These stents are made using different material compositions such as metallic stents are made of stainless steel, nitinol alloys, and elgiloy. Whereas non-metallic stents are made up of synthetic polymers like resins, polyurethane, silicone.
With Habib Samady, MD, and John Wang, MD, MSc. In this edition of our Conversations with Experts series, Habib Samady, MD, director of interventional cardiology and the cardiac catheterization laboratory at Emory University Hospital in Atlanta, speaks with John Wang, MD, MSc, chief of the cardiac catheterization laboratory at MedStar Union Memorial Hospital in Baltimore, about the current and future role of bare-metal stents in the interventional cardiology landscape. Dr. Wang was the national principal investigator of the OMEGA trial, the results from which led to the FDA approval of the REBEL™ Platinum Chromium Coronary Stent System (Boston Scientific Corporation; Natick, Massachusetts).. John Wang, MD, MSc: Dr. Samady, let me first ask you: what percentage of the time do you use drug-eluting stents versus bare-metal stents in your practice? Habib Samady, MD: At Emory University Hospital, we probably use drug-eluting stents 85% of the time and bare-metal stents 15% of the time. Dr. Wang: ...
Fingerprint Dive into the research topics of Are distal protection devices protective during carotid angioplasty and stenting?. Together they form a unique fingerprint. ...
Approximately 70 percent of angioplasty procedures also involve stenting, which is the insertion of a small metal cylinder called a stent into a blood vessel. In this procedure, a collapsed stent is placed over the balloon at the tip of the catheter. When the balloon inflates, the stent pops open and reinforces the artery walls. The balloon and catheter are then withdrawn and the stent remains permanently. In a few weeks, tissue from the artery lining grows over the stent.. There are two types of stents. Bare-metal stents are plain, untreated metal cylinders. Drug-eluting stents (also called drug-coated stents) are coated with medication before they are placed in the artery. This medication helps prevent scarring and lowers the risk for restenosis (re-narrowing of the artery). Drug-eluting stents may present a higher risk for blood clot formation than bare-metal stents. ...
METHODS AND RESULTS Forty-five stents were placed in 30 patients, who were 0.2-30.2 years old (weight, 3.5-76 kg). Patients with areas of stenosis that were difficult to approach surgically were chosen. Stents were mounted over balloons and placed by standard catheterization techniques. Twenty-three patients had branch pulmonary artery stenosis. Thirty-six stents were placed successfully and had reduced pressure gradients from 50.6 +/- 24 to 15.9 +/- 13.4 mm Hg. Five patients had stents placed after atrial surgery: three in obstructed Fontan repairs, one at the superior vena cava-right atrial junction after sinus venous defect repair, and one at the site of a Glenn shunt. Atrial stents reduced pressure gradients from 9.8 +/- 8.2 to 2.0 +/- 2.6 mm Hg. One patient had a stent placed in the descending aorta after coarctation dilation, and the pressure gradient was reduced from 50 to 25 mm Hg. One patient had pulmonary vein dilation with stent placement. Two stents migrated at the time of placement; ...
Our results demonstrate the possibility of therapeutic local gene transfer using a stent platform technology and that VEGF-2 gene-eluting stents may be effective in the prevention of restenosis. The data show that VEGF-2 plasmid was effectively delivered to the vessel wall, where transcript and protein were detected for up to 10 days after stent implantation. Local VEGF-2 gene, delivered by PC-coated stents, not only improved early reendothelialization at the stented site but also reduced neointimal proliferation as assessed by IVUS at 3 months of follow-up. IVUS and histomorphometric assessment revealed significant differences in neointimal formation in hypercholesterolemic animals after implantation of VEGF stents compared with PC control stents. Moreover, and in contrast to all other currently marketed drug-eluting stents, VEGF-2-eluting stents result in acceleration of anatomic and functional endothelial recovery. These data, therefore, represent the first demonstration of an antirestenosis ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. World Stents Market by Product (coronary, peripheral, and stent-related implants), by Material (Metallic, Polymeric, Natural) - Global Opportunity Analysis and Industry Forecast, 2014-2022. View full report at World Stents Market by Product (coronary, peripheral, and stent-related implants), by Material (Metallic, Polymeric, Natural) - Global Opportunity Analysis and Industry Forecast, 2014-2022. Summary:. A stent is a metallic or a polymer tube implanted into the lumen of any blood vessel or a duct in order to keep the passage open. A variety of stents for different clinical conditions are available in the market. A stent implant is most commonly used for the treatment of cardiac abnormalities such as blocked blood vessels. In addition, stents are implanted in the esophagus to allow the passage of food and beverages in patients suffering from esophageal cancer. They are also inserted in the ureter to prevent ...
Vascular Stents Market: By Material (Metal Stents, Standard Polymeric Stents, and Biodegradable Polymeric Stents) & By Region (Europe, North America, Asia-Pacific, RoW)-Forecast (2016-2022) Vascular Stents - Market research report and industry analysis - 10582518
Press Release issued Apr 23, 2015: Cardiovascular devices industry is growing at a significant rate globally, due to increasing number of heart diseases and other cardiovascular problems cases. In addition, technological advancement in this field and growing awareness has increased the growth of cardiovascular devices market. Coronary stents refer to the medical devices that are tubular in nature and fixed in coronary artery to keep artery open, for proper supply of blood. Continuous increase in the cases of cardiovascular problems has led a significant growth in Coronary Stents Market. Out of global market for coronary stents, North American coronary stents market has the largest share. This is due to increased prevalence of coronary heart diseases and technological advancement in the region. In addition, government initiatives and better reimbursement scenario has led to increase in North American coronary stents market.
Coronary artery stenosis is commonly treated by stent placement via percutaneous intervention, at times requiring multiple stents that may overlap. Stent overlap is associated with increased risk of adverse clinical outcome. While changes in local blood flow are suspected to play a role therein, hemodynamics in arteries with overlapping stents remain poorly understood. In this study we analyzed six cases of partially overlapping stents, placed ex vivo in porcine left coronary arteries and compared them to five cases with two non-overlapping stents. The stented vessel geometries were obtained by micro-computed tomography of corrosion casts. Flow and shear stress distribution were calculated using computational fluid dynamics. We observed a significant increase in the relative area exposed to low wall shear stress ( ...
Perioperative Management of Patients with Coronary Stents Perioperative Management of Patients with Coronary Stents 1. Determine the type (BMS, DES) and location in the coronary circulation of stents placed in the 2. When possible, obtain catheterization/stent procedure report to identify any high risk factors for a. Low EF b. Prior coronary brachytherapy c. Long Stents d. Proximal vessel involvement (i.e. L main) e. Multiple Lesions f. g. Ostial/bifurcation lesions h. Small vessels i. 3. Consult with a patients cardiologist and, when high risk, with the interventional cardiologist. When no cardiologist is on record, consult: a. Hillcrest Cardiology Consult b. Thornton Cardiology On-call 4. Perform the surgery in a center with 24-h interventional cardiology coverage so that stent thrombosis, if occurs, could be treated by PCI. 5. Inform patients of risk of perioperative stent thrombosis on preoperative visit ...
Global Market Watch:. BRICSS Coronary Stents market value is expected to reach US$1 billion by 2016, primarily supported by the product types - Drug Eluting Stents, Bare Metal Stents, Absorbable Stents and …etc. China accounts for nearly 28% of the market share and India claims more than 23%. In terms of CAGR, India is the fastest growing region while China and South Korea are just behind. Among the product types, Drug Eluting Stents account more nearly half of the market value while Absorbable Stents segments indicate a close 14%. In case of Stent Coating, Polymer depicts the largest CAGR while Non-Polymer and Inorganic in second and third place respectively.. Browse Full Research Report With TOC on Healthcare Industry division has been witnessing a drastic change regarding the new innovation and technology which in terms are applied in improving from sector to sector since the past 3-5 years. Cardiovascular industry ...
Fingerprint Dive into the research topics of Delayed deformation of self-expanding stents after carotid artery stenting for postendarterectomy restenoses. Together they form a unique fingerprint. ...
Cardiovascular disease is the dominant cause of mortality in developed countries, with coronary artery disease (CAD) a predominant contributor. The development of stents to treat CAD was a significant innovation, facilitating effective percutaneous coronary revascularization. Coronary stents have evolved from bare metal compositions, to incorporate advances in pharmacological therapy in what are now known as drug eluting stents (DES). Deployment of a stent overcomes some limitations of balloon angioplasty alone, but provides an acute stimulus for thrombus formation and promotes neointimal hyperplasia. First generation DES effectively reduced in-stent restenosis, but profoundly delay healing and are susceptible to late stent thrombosis, leading to significant clinical complications in the long term. This review characterizes the development of coronary stents, detailing the incremental improvements, which aim to attenuate the major clinical complications of thrombosis and restenosis. Despite these
Drug eluting stents (DES) have decreased substantially the neointimal formation after percutaneous coronary intervention (PCI). However, DES are not free from neointimal hyperplasia (NIH) and stent thrombosis, which are related to the delayed arterial healing following DES implantation. The recently introduced optical coherence tomography (OCT) enables a detailed investigation of vessel healing. The presence of peri-strut low intensity (PLI) has been described as a potential marker of abnormal neointimal healing (1,2). We investigated the late healing characteristics of stents implanted over 3 years, specifically the potential impact of PLI on NIH and restenosis.. OCT imaging (M2, Lightlab Imaging, Westford, Massachusetts) was performed in 99 patients who were treated with bare-metal stents (BMS), sirolimus-eluting stents (SES) (Cypher, Cordis, Bridgewater, New Jersey), or paclitaxel-eluting stents (PES) (Taxus, Boston Scientific, Natick, Massachusetts) from September 2007 to August 2009. The ...
Coronary stents are tubular type scaffolds that are deployed, using an inflatable balloon on a catheter, most commonly to recover the lumen size of narrowed (diseased) arterial segments. Their presence, however, can lead to adverse biological responses - in-stent restenosis, formation of neointima within 12 months of the implant, and thrombosis, formation of a blood clot inside the artery. Currently, an ideal stent - that recovers arterial shape with no adverse response - does not exist, even though, as a multi-billion dollar industry, stent design has witnessed a fairly rapid evolution from bare metal stents of increasing complexity, through shape memory alloy stents, polymer coated, drug eluting stents to biodegradable stents made from polymers or corrodible metals. The adverse responses are likely to be multi-factorial but their causes are not completely understood. However, there are studies implying a correlation between the stent design, which is a common differentiating factor between ...
Fully covered esophageal self-expandable metallic stents (SEMS) often are used for palliation of malignant dysphagia. However, experience and data on these
There are two types of urethral stents temporary and permanent. Most are made up of stainless steel or Nitinol. Absorbable stents made up of Vicryl are also available. Indication : recurrent short bulbar stricture. Patient unfit for surgery or refuse a surgery.. Contra indication: penile urethral stents are painful during erection. Stents inserted into the membranous urethra after core through urethrotomy for pelvic fracture urethral distraction defects also get blocked due to over growth of fibrosis.. The success rate of urethral stents inserted in the bulbar urethra is quoted in region of 80% a stent may migrate distally forming a stricture at the proximal end exposed part of the urethral stent not covered by urothelium may be encrusted with stones. Overgrowth of excessive epithelization may block the lumen and may need repeated resection. In those patients where the stent has to be removed endoscopic removal of the stent may be possible with some single wire stents but mesh stents need open ...
THESIS 8924 The use of stenting in peripheral arteries has been limited by rates of in-stent restenosis and stent fracture considerably higher than seen in coronary arteries. Traditional balloon expandable stainless steel stents were found to be incompatible in femoral and popliteal arteries. The change to more flexible nitinol stents saw an improvement in restenosis rates, but outcomes were still poor compared with coronary stents. The advent of drug eluting stents, which decreased restenosis rates in coronary arteries, has yet to result in significant improvement in peripheral arteries. Artery movement, caused by joint flexion, has long been thought of as a major contributory factor of the high restenosis rates seen in peripheral arteries. However, this hypothesis has not been adequately assessed, and there are other factors which could contribute to the poor performance of peripheral stents. The material properties and geometries of the coronary and peripheral arteries are different, and the ...
[124 Pages Report] Check for Discount on Global Cerebral Balloon Angioplasty & Stenting Systems Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19 Worldwide Spread) report by Maia Research. The Cerebral Balloon Angioplasty & Stenting Systems market is expected to...
OBJECTIVE: To investigate the use of a cutting balloon to overcome aorto-ostial lesions before stent implantation and thereby reduce the restenosis rate. DESIGN: Observational follow up study. SETTING: Tertiary referral centre. PATIENTS: Eight patients (two female, six male) aged 58.2 (SD 10.1) years with Canadian Cardiovascular Society (CCS) grade II-IV angina were recruited. They each had a single target lesion (three in native coronaries, five in vein grafts). INTERVENTION AND RESULTS: After high pressure angioplasty (18 (3.8) bar), there was only a small reduction in the luminal stenosis, from 82 (9)% to 68 (10)%, as assessed by on line quantitative coronary angiography. However, using the cutting balloon there was a marked reduction in the luminal stenosis to 44 (15)%, facilitating stent insertion. Subsequent high pressure dilatation resulted in a final stenosis of 10 (7)%. At 6 (2) months follow up the marked symptomatic improvement, to CCS angina grade 0-II, was maintained and there were ...
Market Research Trade Published new report Global Aortic Stents Grafts 2019 2019: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts is committed fulfilling the requirements of the clients by giving them thorough insights into the market.. The Global Aortic Stents Grafts 2019 2019 report is expansive research reliant on Global Aortic Stents Grafts 2019, which inspects the raised structure of the present Global Aortic Stents Grafts 2019 2019 all around the globe. Arranged by the adequate methodical framework, for instance, SWOT examination, the Global Aortic Stents Grafts 2019 report exhibits a total evaluation of the significant players of the Global Aortic Stents Grafts 2019. The estimates for CAGR (Compound Annual Growth Rate) is calculated by the Global Aortic Stents Grafts 2019 report in terms of extent for the specific time length. This will similarly help the customer with comprehension and settle on a correct choice depends on a normal chart.. Request Free Sample Report ...
Drug-eluting stents work as well as bare-metal stents at keeping blocked arteries open, according to a meta-analysis in the April 23 Archives of Internal Medicine. Additionally, drug-eluting stents dont increase the risk of death, and theyre more likely to prevent narrowing of the arteries than bare-metal stents. Researchers analyzed records from 11 clinical trials involving a total of 6,551 patients; approximately two-thirds had been fitted with drug-eluting stents and one-third with bare-metal stents. About a year after the stents were placed, there were no significant differences between groups in the risks of death, stent thrombosis, or heart attack recurrence. However, patients with drug-eluting stents required revascularization nearly half as often as those with bare-metal stents. The results, write the authors, provide strong evidence of the beneficial effects of drug-eluting stents compared with bare-metal stents. ...
TY - JOUR. T1 - Comparative Outcomes of Carotid Artery Stent Placement and Carotid Endarterectomy in Patients with Chronic Kidney Disease and End-Stage Renal Disease. AU - Adil, Malik M.. AU - Saeed, Fahad. AU - Chaudhary, Saqib A.. AU - Malik, Ahmed. AU - Qureshi, Adnan I.. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Background Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have a high prevalence of carotid artery stenosis but are excluded from clinical trials. We sought to determine the clinical characteristics and outcomes related to carotid endarterectomy (CEA) and carotid artery stenting (CAS) in ESRD and CKD patients. Methods We determined the frequency of CAS and CEA performed in patients with ESRD and CKD and associated in-hospital outcomes using data from the nationwide inpatient sample data files from 2005 to 2011. All the in-hospital outcomes were analyzed after adjusting for potential confounders using multivariate analysis. Results Of the 43,875 CKD patients ...
TY - JOUR. T1 - Coronary Stenting with a Novel Stainless Steel Balloon-Expandable Stent. T2 - Determinants of Neointimal Formation and Changes in Arterial Geometry after Placement in an Atherosclerotic Model. AU - Carter, Andrew J.. AU - Laird, John R.. AU - Kufs, William M.. AU - Bailey, Lynn. AU - Hoopes, Timothy G.. AU - Reeves, Tim. AU - Farb, Andrew. AU - Virmani, Renu. PY - 1996/4. Y1 - 1996/4. N2 - Objectives. This study evaluated the delivery characteristics and vascular response to placement of a novel balloon-expandable stent in swine with experimentally induced atherosclerosis. Background. The Multi-Link stent is a balloon-expandable stainless steel stent with an interconnected ring structure designed to provide a high degree of compressive resistance while preserving longitudinal flexibility. The placement characteristics and vascular response to this stent in atherosclerotic coronary arteries have not been characterized. Methods. We tested the delivery characteristics and vascular ...
Results-Of 1 083 688 patients who underwent carotid endarterectomy or carotid artery stent placement, 11 341 (1%) patients developed NSTEMI during hospitalization. After adjusting for constitutional variables and risk factors, NSTEMI was associated with higher rates of in-hospital mortality (odds ratio, 8.6; 95% confidence interval, 7.0-10.7; P≤0.0001) and composite end point of stroke, cardiac events, and death (odds ratio, 14.6; 95% confidence interval, 13.0-16.5; P≤0.0001).. ...
Evidence-based recommendations on carotid artery stent placement for symptomatic extracranial carotid stenosis (narrowed carotid arteries in the neck)
Purpose: Comparison of the biocompatibility of self-expanding polyethylene terephthalate (PET) stents with self-expanding metallic stents (Wallstents). Methods: Diameter- and length-matched PET stents and Wallstents were symmetrically implanted in the paired iliac arteries of 13 crossbred domestic swine. Stent deployment was studied angiographically and with intravascular ultrasound immediately after stent implantation. The angiographic stented lumen diameter was measured using quantitative vessel analysis before, immediately after stenting, and at 6-week follow-up. Cross-section histopathology and area morphometry were performed. Results: Immediately poststenting, intravascular ultrasound revealed proximal dislocation of 5 of the 13 PET stents, whereas all metal stents were firmly embedded at the implantation site. At 6-week follow-up, three of the remaining PET stents were totally or subtotally occluded by organized thrombus, whereas all metal stents were patent. Compared with immediately ...
But OCT allows viewing the interior surfaces of the artery and stent in an awake patient. The imaging is done in the cath lab, over the same type of wire as balloons, stents, IVUS, etc. devices are delivered.. The assessment of strut coverage in stents was the goal of the ODESSA Trial (Optical coherence tomography for DES SAfety). Presented last Tuesday by Dr. Giulio Guagliumi of Ospedali Riuniti di Bergamo, Italy, the goal of this trial was to determine whether OCT could accurately measure strut coverage and stent malapposition in long lesions (greater than 20mm) that required overlapping stents. Overlapping stents are associated with an increased incidence of uncovered struts. Although the number of patients (77) and stents (189) was small, the actual number of struts analyzed was 53,047. The stents were further divided in to four groups: sirolimus-eluting (SES) or CYPHER stents, paclitaxel-eluting (PES) or TAXUS stents, zotarolimus-eluting (ZES) or ENDEAVOR stents, and bare-metal stents ...
TY - JOUR. T1 - Efficacy of the Za Self-Expandable Metal Stent for Palliation of Malignant Biliary Obstruction. AU - Varadarajulu, Shyam. AU - Tutuian, Radu. AU - Gostout, Christopher. AU - Kozarek, Richard. AU - Wilcox, C. Mel. AU - Cotton, Peter B.. PY - 2004/1. Y1 - 2004/1. N2 - Background: The efficacy and safety of the uncoated self-expandable Za metal stent for palliation of malignant distal biliary obstruction was prospectively analyzed. Methods: Twenty-one patients with unresectable malignant tumors involving mid to distal common bile duct who presented with obstructive jaundice underwent endoscopic implantation of an uncoated self-expandable metal stent. Technical success with stent placement, adverse events, patient survival, duration of stent patency, and device performance were analyzed. Results: Endoscopic biliary stenting was successful in all patients. No adverse events were encountered. The mean follow-up period of the 21 patients was 128 days (range, 3-263): 14 died of ...
A 67-year-old man with critical limb ischemia due to left common iliac artery (CIA) occlusion underwent endovascular treatment and stent deployment (Express LD, 8.0 × 37 mm and 8.0 × 17 mm, Boston Scientific, Natick, Massachusetts) (Figure 1). The symptoms of ischemia resolved after stent implantation; however, the patient felt pain while at rest in the left leg 3 years later. Angiography indicated a totally occluded left CIA at the stent site. Computed tomography angiography (CTA) revealed that the stent in the left CIA was compressed by a spinal spur (Figure 2). We speculate that the following occurred. The spinal spur gradually compressed the balloon-expandable stent as the patient performed normal daily activities; eventually, it caused the stent to fracture, causing CIA reocclusion. We performed bypass surgery between the femoral arteries to obtain sufficient blood flow to the left leg, and the patients pain was relieved. Stent implantation for stenosis of the iliac arteries is an ...
TY - JOUR. T1 - Self-Expandable Metal Stents in Esophageal Cancer in a High HIV Prevalence Area. T2 - A Survival Analysis and Evaluation of Prediction Scores. AU - Loots, Emil. AU - Anderson, Frank. AU - Clarke, Damian L. AU - Mulder, Chris J J. AU - Madiba, Thandinkosi E. PY - 2016/12. Y1 - 2016/12. N2 - INTRODUCTION: Esophageal cancer (EC) and human immunodeficiency virus (HIV) are common in parts of South Africa. Squamous cell carcinoma of the esophagus in KwaZulu-Natal, South Africa presents generally in advanced stages and is mostly palliated by the deployment of self-expandable metal stent (SEMS). This study analyses these relationships between coexistent HIV infection, SEMS deployment, and survival scores.METHODOLOGY: Information on patients managed with SEMS between October 2013 and December 2014 was retrieved from a prospective database of EC and followed up until April 2015. Data collected included demographics, HIV status, clinical presentation, prognostic indicators, management, and ...
TY - JOUR. T1 - Paclitaxel-eluting stents show superiority to balloon angioplasty and bare metal stents in femoropopliteal disease. T2 - Twelve-month zilver PTX randomized study results. AU - Dake, Michael D.. AU - Ansel, Gary M.. AU - Jaff, Michael R.. AU - Ohki, Takao. AU - Saxon, Richard R.. AU - Smouse, H. Bob. AU - Zeller, Thomas. AU - Roubin, Gary S.. AU - Burket, Mark W.. AU - Khatib, Yazan. AU - Snyder, Scott A.. AU - Ragheb, Anthony O.. AU - White, J. King. AU - Machan, Lindsay S.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/10. Y1 - 2011/10. N2 - Background-Sustained benefits of drug-eluting stents in femoropopliteal arteries have not been demonstrated. This prospective, multinational, randomized study was designed to compare the 12-month safety and effectiveness of a polymer-free, paclitaxel-coated nitinol drug-eluting stent (DES) with percutaneous transluminal angioplasty (PTA) and provisional bare metal stent (BMS) placement in patients with ...
TY - JOUR. T1 - Elective stent-graft treatment of aortic dissections. AU - Lee, Kwang Hun. AU - Jong, Yun Won. AU - Do, Yun Lee. AU - Choi, Donghoon. AU - Shim, Won Heum. AU - Byung, Chul Chang. PY - 2004/12/1. Y1 - 2004/12/1. N2 - Purpose: To retrospectively review 8 years experience with stent-graft treatment of aortic dissections at a single institution. Methods: Forty-six patients (31 men; mean age 59 years, range 38-88) underwent stent-graft treatment for 9 Stanford type A and 37 type B aortic dissections (9 acute phase, 13 subacute, 24 chronic). Custom-designed self-expanding stainless steel Z stents covered with polytetrafluoroethylene were used (n=20) until low-profile modular stent-grafts became available for percutaneous delivery (n=26). Results: Endovascular stent-graft deployment was technically successful in 44 (96%) patients; the 2 failed cases owing to intraprocedural migration and graft torsion were converted to surgery. There were 5 type I endoleaks for a clinical success ...
Despite the success of coronary stent implantations in the last decade, in-stent restenosis due to neointimal hyperplasia remains a problem to overcome. Neointimal hyperplasia is a vascular response to stent injury and mainly consists of proliferation of smooth muscle cells and deposition of extracellular matrix. Recently, local drug delivery has been advocated as a potential strategy to prevent in-stent restenosis. Unprecedented results have been obtained in early clinical studies on sirolimus-eluting and paclitaxel-eluting stents. Trials using various pharmaceutical coatings on different coronary stents are ongoing. More types of drug-eluting stents are expected on the market in the near future. Meanwhile, the evaluation of drug-eluting stents is entering the second phase in which the safety and efficacy in more complex lesion subsets and different clinical presentations are being investigated. Results including cost-benefit analyses are expected to have a tremendous impact on the practice of ...
Introduction Drug-eluting stents (DES) have reduced the rates of restenosis to less than 10%; however, increased incidence of late in-stent thrombosis, is now a major clinical problem of using DES for its consequences in terms of morbidity and mortality. Interference with the process of re-endothelialization appears to play a major role in this latent complication. Thus, the search for molecular compounds capable of preventing restenosis that also can reduce the risk of late in-stent thrombosis is of utmost importance. Previously, we have shown that certain non-steroidal anti-inflammatory drugs (NSAIDs) are capable of inhibiting rat vascular smooth muscle cell proliferation, a key element in the process of restenosis post stent deployment. Here, we evaluated whether proliferation and migration of human coronary artery smooth muscle cells (HCASMCs) is reduced by the NSAID, ibuprofen, whether this correlated with changes in the phenotype of HCASMCs and the potential molecular mechanisms involved. ...
Cypher data were so unequivocal that the FDA panel reviewing the data issued a unanimous recommendation for approval in the fall of 2002. In fact, Cypher appeared to be so effective that the Centers for Medicare and Medicaid Services took the unprecedented step of approving payment prior to the official FDA approval and launch that occurred in late April 2003. Cypher had been approved in Europe in early 2002; Taxus was released there earlier this year.. Cardiologists appear to favor the eluting stents over the bare metal stents. This preference will allow the drug-eluting stents to overtake the traditional bare metal version rapidly. In fact, Wall Street analysts predict that by the end of 2003, eluting stents will have 40 percent of the market.. Although promising to reduce the restenosis rate even further, these stents, too, are not without drawbacks. Cypher has a list price of $3,195 per stent (any size or length); several times the cost of the bare metal stents, which have decreased in price ...
TY - JOUR. T1 - Sirolimus- Versus Paclitaxel-Eluting Stents for the Treatment of Coronary Bifurcations. Results From the COBIS (Coronary Bifurcation Stenting) Registry. AU - Song, Young Bin. AU - Hahn, Joo Yong. AU - Choi, Seung Hyuk. AU - Choi, Jin Ho. AU - Lee, Sang Hoon. AU - Jeong, Myung Ho. AU - Kim, Hyo Soo. AU - Seong, In Whan. AU - Yang, Ju Young. AU - Rha, Seung Woon. AU - Jang, Yangsoo. AU - Yoon, Jung Han. AU - Tahk, Seung Jea. AU - Seung, Ki Bae. AU - Park, Seung Jung. AU - Gwon, Hyeon Cheol. PY - 2010/4/20. Y1 - 2010/4/20. N2 - Objectives: We aimed to compare the long-term clinical outcomes of patients treated with sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES) for coronary bifurcation lesions. Background: There are limited data regarding comparisons of SES and PES for the treatment of bifurcation lesions. Methods: Patients who received percutaneous coronary intervention for non-left main bifurcation lesions were enrolled from 16 centers in Korea between January ...
TY - GEN. T1 - Design and optimization of functionally graded superelastic niti stents. AU - Khurana, Jivtesh B.. AU - Frecker, Mary. AU - Pauli, Eric M.. N1 - Funding Information: The authors gratefully acknowledge the support of the Pennsylvania Manufacturing Innovation Program.. PY - 2020. Y1 - 2020. N2 - Endoscopic stents are being used by surgeons in off-label uses to manage leaks and perforations in the gastrointestinal tract. Commercially available stents are primarily designed to open strictures in the esophagus through tissue compression. The stents incorporate a woven NiTi wire to produce a stiff and linear tubular shape that conforms to the esophagus. In off-label uses, where the stents are placed in non-esophageal locations the stents must bend, the stents show a high propensity to migrate from their initial location causing unwanted complications. In this paper, a new stent design incorporating functionally graded NiTi is presented and explored. First, a functionally graded NiTi ...
Be informed that , National Pharmaceuticals Pricing Authority (NPPA) vide notification bearing number SO NO 412(E) dated 13th February 2017 has fixed a ceiling price on Bare Metal Stents and Drug Eluting Coronary Stents
Data were obtained from the National Inpatient Sample (NIS) from 2002 to 2009, which includes all-payer discharge information from a national survey of nonfederal hospitals. A comprehensive synopsis on NIS data is available at International Classification of Disease, 9th Revision; Clinical Modification (ICD-9-CM) codes and procedure codes 00.63 and 38.12 were used, respectively, to identify patients undergoing CAS or CEA. Patients with both procedure codes were excluded. If a patients discharge diagnosis (diagnostic fields 1-15) was either carotid artery stenosis with stroke (433.11) or, if there was carotid artery stenosis without stroke (433.10), with subsequent code for transient ischemic attack (435), patients were classified as symptomatic. ICD-9-CM diagnosis code 410.71 was used to identify cases with NSTEMI. We excluded all the patients with other types of MI using ICD-9 diagnosis codes 410.0 to 410.6 and 410.8 to 410.9.. Study variables include age, sex, ...
TY - JOUR. T1 - Carotid Stenting Using Tapered and Nontapered Stents. T2 - Associated Neurological Complications and Restenosis Rates. AU - Brown, Katherine E.. AU - Usman, Asad. AU - Kibbe, Melina R.. AU - Morasch, Mark D.. AU - Matsumura, Jon S.. AU - Pearce, William H.. AU - Amaranto, Daniel J.. AU - Eskandari, Mark K.. PY - 2009/7/1. Y1 - 2009/7/1. N2 - Self-expanding stent design systems for carotid artery stenting (CAS) have morphed from nontapered (NTS) to tapered (TS); however, the impact of this change is unknown. We reviewed the outcomes of CAS with these two broad categories of stents in a single-center retrospective review of 308 CAS procedures from May 2001 to July 2007. Nitinol self-expanding TS or NTS coupled with cerebral embolic protection devices were used to treat extracranial carotid occlusive disease. Data analysis included demographics, procedural records, duplex exams, and conventional arteriography. Mean follow-up was 18 months (range 1-69). Restenosis was defined as ...
Carotid endarterectomy is the main treatment for narrowing of the carotid arteries, but sometimes an alternative procedure called carotid artery stent placement may be available.. Its a less invasive procedure than a carotid endarterectomy because theres no need to make a cut in the neck. Instead, a thin flexible tube is guided to the carotid artery through a small cut in the groin. A mesh cylinder (stent) is then placed into the narrowed section of artery to widen it and allow blood to flow through it more easily.. Current guidelines recommend that a carotid endarterectomy should be the first line of treatment for most people. This is because carotid stenting is associated with a higher risk of stroke during the procedure, particularly if its carried out in the first few days after symptoms appear. But its an important alternative for some people who may otherwise be considered to be high risk because of other medical problems.. Find out more about carotid artery stent placement. ...
Carotid endarterectomy is the main treatment for narrowing of the carotid arteries, but sometimes an alternative procedure called carotid artery stent placement may be available.. Its a less invasive procedure than a carotid endarterectomy because theres no need to make a cut in the neck. Instead, a thin flexible tube is guided to the carotid artery through a small cut in the groin. A mesh cylinder (stent) is then placed into the narrowed section of artery to widen it and allow blood to flow through it more easily.. Current guidelines recommend that a carotid endarterectomy should be the first line of treatment for most people. This is because carotid stenting is associated with a higher risk of stroke during the procedure, particularly if its carried out in the first few days after symptoms appear. But its an important alternative for some people who may otherwise be considered to be high risk because of other medical problems.. Find out more about carotid artery stent placement. ...
no one suspected the results from the new study, said Morton Kern, a professor of medicine at UC Irvine. It is one other potential downside to drug-eluting stents, Kern said. The study likely will focus more attention on the process of collateral blood-vessel formation as well as developing new generations of drug-coated stents that dont hinder that process, he said. When drug-coated stents became popular in 2003, they were heralded as a major breakthrough in treating heart disease. The tiny, expandable mesh-like tubes were shown to be far superior to bare-metal stents in preventing the gradual reblockage of arteries, a troubling but seldom fatal process known as restenosis. Drug-coated stents are covered by medicine that slowly dissolves and that can dramatically reduce the formation of scar tissue that can re-block an artery. About 1 million Americans are implanted with stents each year and an estimated 80 percent of those devices are drug-coated. However, in recent months researchers and ...
Use of drug-eluting stents is associated with a lower risk of major cardiovascular events at one year compared to bare metal stents when followed by an individualized course of blood-thinning medication among patients previously thought to be uncertain candidates for drug-eluting stents due to their heightened risk of bleeding or blood clots, according to research presented at the American College of Cardiologys 63rd Annual Scientific Session.
Medical literature has recently focused on very late stent thrombosis (VLST) after drug-eluting stent implantation, while its mechanistic issue was not fully explored in the bare-metal stent (BMS) era. The first case is a 59-year-old man presenting with inferior non-ST-segment elevation myocardial infarction, 4 years after BMS implantation (NIR 3.5/18 mm, Boston Scientific, Galway, Ireland) for a chronic total occlusion lesion in the proximal right coronary artery. Coronary angiograms showed Thrombolysis In Myocardial Infarction (TIMI) flow grade 1 and filling defects in the BMS deployed previously, and massive red thrombi attaching to uncovered stent struts were found by angioscope (Fig. 1,Online Video 1). Thrombectomy and adjunctive balloon angioplasty were performed based on the angioscopic findings, and TIMI flow grade 3 was obtained. The second case is a 71-year-old man who was admitted for a diagnosis of inferior non-ST-segment elevation myocardial infarction 10 years after a treatment ...
Apparatus and methods for stenting are provided comprising a self-expandable stent that is at least partially covered with a biocompatible material configured to prevent dynamic self-expansion of the stent. The biocompatible material is irreversibly expandable by suitable means, for example, a balloon. Thus, the apparatus may be tailored in-vivo to a vessel profile, in a manner similar to a balloon-expandable stent, but maintains the flexibility required for use in tortuous anatomy and in vessels that undergo temporary deformation, in a manner similar to a self-expandable stent. Apparatus is also provided for stenting at a vessel branching, and for localized delivery of therapeutic agents.
Aims: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries. Methods and Results: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts. A 2D parallel-plate flow chamber with 100 μm ridges arranged perpendicular to the flow was used. Live cell imaging coupled to computational fluid dynamic simulations revealed that EC migrate in the direction of flow upstream from the ridges but subsequently accumulate downstream from ridges at sites of bidirectional flow. The mechanism of EC trapping by bidirectional flow involved reduced ...
TY - JOUR. T1 - Drug-eluting balloon versus second generation drug eluting stents in the treatment of in-stent restenosis. T2 - a systematic review and meta-analysis. AU - Liou, Kevin. AU - Jepson, Nigel. AU - Cao, Christopher. AU - Luo, Roger. AU - Pala, Sarvpreet. AU - Ooi, Sze-Yuan. PY - 2016/12. Y1 - 2016/12. N2 - Background In-stent restenosis (ISR) remains a significant mode of stent failure following PCI. The optimal treatment strategy, however, remains undefined and the role of drug-eluting balloons (DEB) in the management of ISR is also unclear.Methods A meta-analysis was performed to compare the efficacy of DEB in the treatment of ISR against second generation drug eluting stents (DES).Results Seven studies comprised of 1,065 patients were included for analysis. The follow-up period ranged from 12-25 months. The use of DEB was associated with an inferior acute gain in minimal luminal diameter (MLD) (0.36, 95% CI: 0.16-0.57 mm), higher late loss in MLD (0.11, 0.02-0.19 mm) and a higher ...
COMMENTS. Coronary stents have been widely used throughout the world to treat severe coronary injuries. A recent analysis of six North-American hospitals demonstrated the growth in the use of stents at a rate of 6.8% per year, in contrast to coronary artery bypass grafting, which is declining at a rate of 1.9% per year (6). In the group of patients treated for ischemic heart disease, 65.4% were treated with PCIs, of which 83% of cases underwent interventions involving a single vessel. Over the last three years, these numbers have not changed significantly. However, it is comprehensible that, for a growing number of cases in which surgery is indicated, the patients have already been treated using endoprostheses. Surgical group reports concerning these patients include the observation that the tissues which surround stents and even the coronary arterial wall itself present with an inflammatory-type reaction not previously identified in patients without stents. The formation of a granuloma-type ...
MAIA, Felipe et al. Comparison of vascular response to different doses and patterns of elution of sirolimus-eluting stents using coronary intravascular ultrasound. Rev. Bras. Cardiol. Invasiva [online]. 2009, vol.17, n.3, pp.320-326. ISSN 2179-8397. BACKGROUND: Positive vascular remodeling after percutaneous coronary intervention (PCI) using drug-eluting stents may be associated to a high dose of an anti-proliferative agent and/or local toxicity of the synthetic polymer. This may lead to late incomplete aposition of the struts, acting as a late/very late thrombosis risk factor. Our objective was to assess the vascular response secondary to sirolimus drug-eluting stent implantation using different doses and patterns of elution by means of serial intravascular ultrasound (IVUS) analysis. METHOD: We assessed 50 patients with low to moderate cardiovascular risk divided into 3 groups according to the sirolimus dose and pattern of elution: group 1, ...
Heart (coronary) artery blockage is a local blocking or narrowing in the arteries on the outer surface of the heart by accumulated deposits of plaque, which is mostly bad cholesterol. Every artery in the body is a blood pipeline. These pipelines get blocked with accumulation of bad cholesterol. When a cardiologist suspects blockage or narrowing of any of these heart arteries he/she will perform an angiography (threading a catheter up a thigh artery to the heart to inject a dye that is visible on X-ray) to view the inside of the arteries. When an area of artery narrowing or blockage is identified a catheter with a balloon is inserted along the same path and inflated at the problem area to open it up. This is called angioplasty. Increasingly stents are placed at these angioplasty sites to keep them open in the long term. In some cases multiple stents are sequentially placed in the same artery. If the area cannot be treated in such a fashion open heart surgery is required which involves opening the ...
AIMS: To provide insight on the patients with long lesions that received multiple, overlapping stents by reporting clinical outcomes, together with a detailed angiographic and intravascular ultrasound analysis of the overlap zone. METHODS AND RESULTS: TAXUS VI is a prospective, multicentre, double-blind, trial, specifically designed to assess outcomes of paclitaxel-eluting stents in longer lesions by randomising 446 patients (1:1) between a drug-eluting TAXUS Express2 Moderate Release (MR) and an uncoated Express2 control stent. Multiple overlapping stents were implanted in 124 patients (27.8%) and are the subject of this report. Clinical, angiographic and IVUS outcomes at nine months were compared in the overlap group for patients receiving the TAXUS Express2 MR stent and the uncoated Express2 stent. In the overlap group, mean lesion length was 25.1 mm with a mean stent length of 43.6 mm. At nine months, TVR was reduced by 94% from 25.0% to 1.6% in the TAXUS patients compared with control (p=|0.0001);
Introduction The use of carotid artery stenting to treat carotid bifurcation stenosis remains a topic of recent investigation and vigorous debate regarding safety and efficacy. Multiple prospective randomized controlled trials have compared carotid endarterectomy (CEA) with carotid artery stenting (CAS) and have shown comparable outcomes in asymptomatic patients. There are certain complications that are more…
DESs have dramatically decreased the need for coronary artery bypass graft (CABG) surgery and repeated PCI. However, late stent thrombosis is a small but important risk with DESs because it is commonly associated with sudden death or acute MI. The clinical occurrence of stent thrombosis after stent implantation can be defined as acute (, 24 h), subacute (1 to 30 d), late (30 d to 1 y), or very late (, 1 y). The clinical diagnosis of stent thrombosis can be defined as definite if proven angiographically or pathologically, probable if an MI occurs in the distribution of the stented artery, or possible if death is unexplained (1). Risk for subacute stent thrombosis is about 1% for both DESs and BMSs, but risk for very late stent thrombosis continues for at least 4 years with DESs at a rate of 2 to 4 events/1000 patients per year (1−3). The presumed cause is delayed or incomplete endothelialization of the stent struts. The unanswered question is whether the decrease in risk for death and MI ...
OBJECTIVE: We sought to characterize the long-term outcomes of patients undergoing intracoronary brachytherapy using Beta- irradiation (Beta-BT). BACKGROUND: Beta-BT is effective in reducing angiographic restenosis as well as target vessel revascularization (TVR) in patients with in-stent restenosis (ISR) after bare-metal stenting (BMS). METHODS: 81 consecutive patients undergoing Beta-BT for ISR (irradiated length 32 [32-54] mm) after BMS in native vessels (n = 79) or saphenous vein grafts (n = 2) between 2001 and 2003 were followed. Major cardiac events (MACE), including cardiac death, nonfatal myocardial infarction (MI), and TVR occurring , 1 year or , 1 year were assessed 5.2 (4.4-5.6) years after the index procedure. RESULTS: During the entire follow-up period, the total MACE rate was 49.4%. Within the first year and at , 1 year, MACE rates were 25.9% and 23.5%, cardiac death occurred in 2.4% and 6.2%, and nonfatal MI in 6.2% and 12.3% for annual cardiac death/MI rates of 8.7% at 32 mm ...
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by Physicians Weekly , Dec 28, 2010. The 37th annual Veith Symposium was held from November 17 to 21 in New York City. The features below highlight some of the news emerging from the meeting. Analyzing Different Stenting Approaches for Restenosis The Particulars: Few studies have compared the use of drug-eluting stents after angioplasty with balloon angioplasty and bare-metal stenting in the treatment of restenosis. The Zilver PTX (Cook Medical, Inc.) is the first drug-eluting stent approved for the superficial femoral artery and is currently under investigation in the United States for use in restenosis. Researchers conducted a study comparing the Zilver PTX drug-eluting stent after angioplasty with balloon angioplasty and bare-metal stenting. Data Breakdown: The study enrolled 479 patients at 56 institutions in the United States, Japan, and Germany, with 241 patients randomized to the Zilver PTX group and 238 to the bare-metal stenting group. Demographics and lesion characteristics were ...
Coronary stents are the most commonly used treatment in the United States to repair narrowed or weakened arteries. The ability to visualize the stent during the stenting procedure and post-surgery is crucial to correctly place the stent with respect to the vessel stenosis, and to identify its position within the vessel wall. Current imaging modalities suffer from low contrast, resolution and/or unfavorable artifacts that can inhibit correct visualization of the stent in the artery. We demonstrated the effectiveness of a combined intravascular photoacoustic and intravascular ultrasound imaging method for high resolution and sufficient contrast imaging of commercial stents with respect to the vessel wall.. ©2009 Optical Society of America. Full Article , PDF Article ...
In the randomized SES bifurcation study (2), the rate of restenosis in the side branch was 21.8%. Incomplete coverage of the side branch was advocated as a possible cause for the high restenosis rate (2,8). In order to guarantee full coverage of the ostium of the side branch, the crush stent technique was introduced (3). Our preliminary experience with the crush stenting technique did not show a clear improvement in the rate of restenosis at the side branch. At that time FKB was not performed routinely when no residual stenosis was observed at ostium of the side branch. Learning from follow-up results led to more frequent performance of FKB. Since January 2003, kissing inflation became standard procedure. In the present study, the restenosis rate of the side branch in the FKB group was 11.1%. Compared to the SES bifurcation study, a 49% relative reduction in the restenosis rate in the side branch was achieved (2). The significant reduction of late loss in the side branch after FKB can be ...
Hopefully this does not mean a stint on Patmos.. What I lack in youth I make up for in immaturity. ...
Hopefully this does not mean a stint on Patmos.. What I lack in youth I make up for in immaturity. ...
Archer takes the first stint but is found shot dead that night. Thursby is also killed later and Spade is a suspect. The next ...
Again you cant treat heart disease only via stents and surgery - the causes must be addressed. Women have children they cant ... Its like limiting yourself to stents and bypasses as the only means of dealing with heart disease. ...
Their stint with the CPA was their first real job out of college. Experience or education in the field didnt matter. One guy ...
bacterial colonization of ureteric stent Last post by ras2701 « Mon Jul 10, 2017 1:33 pm. Posted in The KPG Forum ...
bacterial colonization of ureteric stent Last post by ras2701 « Mon Jul 10, 2017 1:33 pm. Posted in The KPG Forum ...
superior vena cava blocked: stent but face remains puffy. April 2012: Teresa Trial, randomised to TDM1. Nov 2012 progressing on ...
My last stint at Davis-Besse was in 1991. The plant was still struggling from past modifications that were completed after the ...
The Beijing Institute for Brain Disorders has been using stents to repair slowed jugular... ...
Vettel was held up by Trulli who was on the medium tyre compound in the middle stint. Both of them drove well, but couldnt ...
Hi all, well there was one small benefit from my displaced Stent. Last post by CureIous « Sat Jul 24, 2021 4:09 pm Posted in ...
I doubt senile Joe even recalls his stint as KKK Cyclops. Biden is old, but not senile. Its about time people stop with that ...
Hugs Helen* Curvebal really distracts me for a 5 minute stint at a time yep .. I am at my parents sat in the living room with ...
Hugh Gaitskell died and Harold Wilson began his long stint as leader of the Labour Party. Russia put the first woman into space ...
Finally, Watson doesnt stint from giving us some detail that a modern popularizer would shy away from. The information on ...
Im Tim and am a new rider (except for a short stint 20+ years ago). Ive been riding a Vespa GTS 300 since moving to SoCal ( ...
Somebody tell me why Hugh Grant should get it other than his movies and his stint with a prostitute?? :eek: ...
Looks like Josh Donaldsons rehab stint in Dunedin is not going as well as planned. Donaldson played Tuesday but reports ...
My mom is vaccinated, my dad is waiting for an inactivated one since he has stents in his heart and is prone to blood clots. So ...
Calder finished his career with a return stint as Eddy Grant s manager.. According to reports, Calder died of complications ...
Towards the end of my stint I reformed the GameMasters into the Event Squad, so that the team could focus on events rather than ...
... and stayed with my brother whom had just spent a two year stint of unemployment reading all he could find on Astrology. This ...
... to a Specialist of the Delest Frontier Fleets and considerably improved chances in finding civilian employ when your stint with ...
  • The stent is inserted along with the balloon catheter. (
  • Using the catheter, the doctor places a stent in the vessel that needs to be held open. (
  • The balloon catheter is deflated and removed, leaving the stent permanently in place to hold the coronary artery open. (
  • To keep the vessel open, doctors usually add a stent to the end of the balloon catheter. (
  • Such a stent may be deployed by winding the stent onto a catheter, immobilizing the two ends of the wire and one or more intermediate points, bringing the stent to the location where it is to be deployed, and releasing first the intermediate point or points and then the end points. (
  • The implant consists of a self-expanding stent mounted on a delivery catheter system. (
  • The delivery catheter is a long, thin, tube-like device used to deliver the stent into the artery. (
  • After the GORE® Embolic Filter is in place, the doctor inserts the GORE® Carotid Stent delivery catheter into the leg and moves the stent to the blocked area in the neck. (
  • The GORE® Carotid Stent is then released from the catheter and opens automatically over the blockage. (
  • The stent delivery catheter and the GORE® Embolic Filter are both removed. (
  • have problems preventing the GORE® Carotid Stent catheter from getting to the blockage. (
  • Doctors insert the stent -- a tiny mesh tube -- into the clogged artery with a balloon catheter. (
  • The VICI VENOUS STENT® System has two components: a stent made of a nickel-titanium alloy (nitinol) tubing and an over-the-wire stent delivery catheter system. (
  • Have a lesion that prevents complete inflation of a balloon dilatation catheter or proper placement of the stent or the stent delivery system. (
  • Your doctor will insert a balloon catheter into the carotid stent to open it wider. (
  • In carotid stenting, a long, hollow tube (catheter) is threaded through the arteries to the narrowed carotid artery in the neck. (
  • The stent is designed to be manually crimped onto a non-compliant PTA balloon catheter that is indicated for biliary stent expansion. (
  • Once the stent is placed within the artery, the balloon is deflated and removed with the catheter. (
  • The stent incorporates platinum chromium (PtCr) alloy and features a catheter delivery system designed to facilitate deliverability in treating patients with coronary artery disease. (
  • Once the stent is in place, the balloon is deflated and the catheter and balloon will be removed. (
  • Once the catheter reached the blockage, the doctor inserted a stent or, if the patient was getting the sham procedure, simply pulled the catheter out. (
  • The most common use for coronary stents is in the coronary arteries , into which a bare-metal stent , a drug-eluting stent , a bioabsorbable stent, a dual-therapy stent (combination of both drug and bioengineered stent), or occasionally a covered stent is inserted. (
  • Common sites treated with peripheral artery stents include the carotid , iliac , and femoral arteries. (
  • Although the most common use of stents is in coronary arteries, they are widely used in other natural body conduits, such as central and peripheral arteries and veins, bile ducts, esophagus, colon, trachea or large bronchi, ureters, and urethra. (
  • Most of the time, stents are used to treat conditions that result when arteries become narrow or blocked. (
  • Brain stent, stent in the heart arteries? (
  • Q).What is the current perception and adoption of vascular stents for treating indications, including the iliac, femoropopliteal and infrapopliteal arteries in the lower extremity? (
  • The coronary stent is used to keep coronary arteries expanded, usually following a balloon angioplasty or other interventional procedure. (
  • March 26, 2007 (New Orleans) -- Hundreds of thousands of Americans may undergo unnecessary angioplasty and stent procedures to open clogged heart arteries each year, a landmark study suggests. (
  • Most of the time, stents are used when arteries become narrow or blocked. (
  • Stents are small tubes or tubular shaped meshes which are used to keep or rebuild the luminal size of passages in the human body like coronary arteries or the esophagus. (
  • Stents can be utilized as implants or in conjunction with an angioplasty (a technique for widening narrowed arteries). (
  • A stent is a medical device that can be inserted inside the body to bypass normal vessels in the body such as veins, arteries, and other passages. (
  • The Cardiac Cath Lab at Dr. P. Phillips Hospital currently performs peripheral vascular angioplasty and stenting (meaning arteries other than those around the heart, such as in the legs, arms, stomach or kidneys). (
  • The giant federal study that found the use of stents in stable heart-disease patients is no better than drugs to treat clogged arteries reached another, less-hyped conclusion. (
  • A major new study has concluded that the use of stents in stable heart disease patients is no better than drugs to treat clogged arteries. (
  • TUESDAY, Nov. 13, 2018 (HealthDay News) -- People with both diabetes and multiple clogged heart arteries live longer if they undergo bypass surgery rather than have their blood vessels reopened with stents, according to follow-up results from a landmark clinical trial . (
  • That's important news for about one-quarter of patients now receiving stents, because they are diabetic with many blocked arteries and would benefit more from bypass surgery, said study senior researcher Dr. Valentin Fuster. (
  • In 2012, the first FREEDOM results showed that diabetics with many blocked arteries had fewer heart attacks and strokes and were less likely to die if they underwent bypass surgery instead of getting a stent . (
  • Stents can clog over time, and don't address widespread hardening of the arteries in these patients, Valentine and Fuster said. (
  • that is, does the coating remain in place on the metallic stent or are small particles released downstream as the stent travels through the arteries to the implantation site? (
  • Stents and coronary bypass surgery reduce chest pain caused by inadequate blood supply, but medication and lifestyle modifications are just as effective as these procedures in preventing heart attacks , heart-related hospitalizations and death in people who have blocked arteries. (
  • Inside the coronary arteries of millions of americans are stents, metal mesh tubes the length of a dime that prop open narrowed blood vessels to help prevent heart attacks. (
  • But in about a quarter of patients, scar tissue builds up in and around the stents three to six months after they're inserted, threatening to reclog arteries. (
  • The GORE® Carotid Stent is used to re-open narrowed regions of the carotid arteries in the neck which supply blood to the brain. (
  • According to the American Heart Association, stents help keep coronary arteries open and reduce the chance of a heart attack. (
  • When my patients tell me proudly that they have five stents in one artery or a total of ten stents distributed over their various coronary arteries, I dare not belittle this achievement of modern technology by paying it no attention. (
  • But in reality after stents are inserted dangerous clots can form within them or opened up arteries can get reclogged or patients consigned to taking powerful blood thinners for the rest of their lives can bleed into their brains or other parts of their bodies, suffering new complications. (
  • St. Joseph begins sending letters to roughly 600 of Midei's patients telling them they might have had unneeded stents implanted in their coronary arteries and suggesting that they see a doctor. (
  • TORONTO, March 31 - Patients whose carotid arteries were opened with a stent, combined with a neuroprotective device, showed significant improvements in cognitive function six months later, a researcher reported here today. (
  • At present, the only patients treated with just balloon angioplasty are those with vessels less than 2mm (the smallest diameter stent ), certain types of lesions involving branches of coronary arteries, those with scar tissue in old stents, or those who cannot take the antiplatelet blood thinners after the procedure. (
  • For instance, they found that stents with an 'open design'--where every other horizontal rod is taken out--bend easily, which makes them good to put in curvy coronary arteries. (
  • Select the Protégé™ GPS™ self-expanding peripheral stent system when your work depends on precision, radial strength and flexibility in treating lesions in the common or external iliac arteries, subclavian arteries or in the biliary system. (
  • The changes reflect the controversy that has enveloped coronary stents, which are threaded through the circulatory system on catheters to prop open blocked arteries. (
  • Drug-based management of partially blocked arteries costs $9,451 less per patient over a lifetime than stenting, according to a 2008 study in the journal Circulation. (
  • In its letter to physicians, the manufacturer notes that some cardiologists may be inappropriately inserting the stents, mainly by overexpanding narrower stents so that they will fit in arteries with larger diameters. (
  • Stents are used to restore blood flow in arteries that have narrowed due to plaque build-up. (
  • Depending on stent location and severity of the blockage, additional steps might include gradually increasing balloon size until the artery can be widened enough to place the stent, and using a filter in the carotid arteries to prevent blood clots and plaque from moving to the brain during the procedure. (
  • Coronary stents have revolutionized the treatment of heart disease, but they leave metal scaffolding inside arteries that can occasionally cause immune reactions and blood clots, and interfere with future surgeries. (
  • Surgeons use stents to open blocked arteries, but the devices can cause complications. (
  • According to research published this month in The Lancet , the stent appeared to be almost completely absorbed after two years, with no instances of cardiac death, no known cases of stent thrombosis, and no evidence that the arteries had begun to re-narrow. (
  • If you have CAD and plaque build-up in your arteries, your doctor may want to insert a stent. (
  • Stent retrievers are mesh devices that are threaded through a blood vessel in the groin to blocked arteries in the head under X-ray guidance to grab and remove the clot. (
  • A stent is a wire mesh that keeps open surgically cleared arteries. (
  • Their study focused on the insertion of stents, tiny wire cages, to open blocked arteries. (
  • This type of stent may lower the chance of the artery closing back up in the future. (
  • The larger question, of course, is not just which type of stent to use. (
  • Annualized PVS market revenue by type of stent and indication in the lower extremity, annual cost of disease and vascular stent adoption pattern data from 2010-2012 and forecast for seven years to 2019. (
  • This type of stent is removed either at home or in the doctor's office. (
  • At that point, there was a question about the optimal treatment for this patient regarding the type of stent to be selected and the need for future combined antiplatelet and anticoagulation treatment. (
  • In particular, consideration should be given to the urgency of the surgery and to the mode of revascularization, including, when applicable, the type of stent to be used. (
  • The indications for airway stenting, types of stents, insertion technique, and potential complications are reviewed here. (
  • Also, patients are generally unaware of the choices they have in terms of the types of stents and the various brands that are available in the market, and have to buy stents directly from the hospitals. (
  • Several types of stents are available for different indications. (
  • Vascular stents made of metals can lead to thrombosis at the site of treatment or to inflammation scarring. (
  • Which kind should you recommend: drug eluting stents, which may prevent early restenosis better but are more expensive and may lead to late thrombosis? (
  • Or bare metal stents, which may not be as good at preventing restenosis initially but are cheaper and less likely to lead to late thrombosis? (
  • Stent thrombosis is a rare complication of percutaneous coronary intervention and carries a poor prognosis. (
  • Recent improvements in stent technology and new antiplatelet therapies have reduced the incidence of stent thrombosis. (
  • Coronary stent thrombosis has been defined by the Academic Research Consortium criteria. (
  • By employing OCT, a number of pathologies such as malapposition, rupture of neoatherosclerosis, uncovered struts, restenosis, evagination, underexpansion, and dissection of the borders have been identified as risk factors for coronary stent thrombosis, allowing causal and specific treatments. (
  • Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry. (
  • Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. (
  • Stent thrombosis in drug-eluting or bare-metal stents in patients receiving dual antiplatelet therapy. (
  • Kang S-H, Chae I-H, Park J-J, Lee HS, Kang D-Y, Hwang S-S, Youn T-J, Kim H-S. Stent thrombosis with drug-eluting stents and bioresorbable scaffolds: evidence from a network meta-analysis of 147 trials. (
  • The VICI VENOUS STENT® System is used to reopen narrowed regions of the iliofemoral vein caused by a collection of blood clots that can form along the lining of the veins following a deep vein thrombosis (post-thrombotic syndrome) or the squeezing of the iliofemoral vein between a bone and an overlying artery (iliofemoral compression). (
  • Early experience with the CYPHER stent has shown that stent thrombosis occurs in 0.5% of patients. (
  • Since the product was approved in the United States, the FDA has received 47 reports of stent thrombosis that occurred at the time of implantation or within a few days of implantation. (
  • 5 Although it is unclear whether the rate of stent thrombosis that is being detected in clinical practice is higher than that observed in the pre-approval clinical trials, the manufacturer issued a warning letter to US physicians on July 7. (
  • The materials used incite an immune response, and damage to the artery wall can trigger the formation of blood clots that, once dislodged, can cause stroke or other damage in a process called late stent thrombosis. (
  • If you have a stent that's bioabsorbable, could return a vessel to its native condition and protect it from late-stent thrombosis, that's an inherently appealing concept, especially when you talk about the fact that we're implanting about a million patients per year here in the U.S.," says Gregg Stone , director of cardiovascular research and education at New York-Presbyterian Hospital and the Columbia University Medical Center. (
  • This innovative stent is also supported by strong clinical outcomes from the PLATINUM trials, which demonstrated very low rates of revascularization and stent thrombosis at one year. (
  • Oral anticoagulation was routinely used for coronary stent thrombosis prevention during the first era of stents. (
  • and the duration of treatment are essential considerations in relation to the risk of stent thrombosis/thromboembolic events and bleeding risk. (
  • Interruption of OAA therapy, as often happens for noncardiac surgery, has been shown to be an important factor in stent thrombosis. (
  • 1,2 In recent years, there has been an explosion in the use of DES, for which the risk of stent thrombosis, although likely to be similar to the standard bare-metal stent in the early phase, is less well defined owing to the longer, potentially indefinite period of time over which it may occur. (
  • 3 Concern about the possible increased incidence of stent thrombosis with DES led to the publication of a consensus statement that highlighted the importance of not prematurely discontinuing dual OAA therapy and increasing its recommended duration in the case of DES to 1 year. (
  • The timing and definition of stent thrombosis vary between studies, which has led to a call for standardizing definitions. (
  • 5 In addition, although most of the trials have included low-risk patients and coronary lesions, the use of DES in the real world is much less controlled, potentially increasing the risk of stent thrombosis. (
  • It has been well established that patients who undergo noncardiac surgery soon after stent implantation are at increased risk for stent thrombosis. (
  • First generation DES effectively reduced in-stent restenosis, but profoundly delay healing and are susceptible to late stent thrombosis, leading to significant clinical complications in the long term. (
  • This review characterizes the development of coronary stents, detailing the incremental improvements, which aim to attenuate the major clinical complications of thrombosis and restenosis. (
  • Clogging of the inside of the stent (in-stent restenosis). (
  • Drug-eluting stents with pharmacologic agents or as drug delivery vehicles have been developed as an alternative to decrease the chances of restenosis. (
  • By forming a rigid support, the stent can prevent the vessel from reclosing (a process called restenosis) and reduce the need for coronary bypass surgery. (
  • These coated stents have significantly reduced restenosis rates - down to 3% - in some clinical studies. (
  • Drug-eluting stents - These stents are coated with medications that prevent inflammation and restenosis of the artery on a long term basis. (
  • One of the most common complications when using stents is in-stent restenosis and stent loss. (
  • In-stent restenosis is the renarrowing of the implanted stent which occurs in ~ 30 % of all cases. (
  • To prevent restenosis drug eluting stents have been developed. (
  • The inner surface of the stent is microstructured limiting laminar flows and preventing in-stent restenosis. (
  • With bare metal stents, scar tissue was known to form within the device, leading to re-narrowing, a condition called restenosis, Dr. Bram Zuckerman, director of cardiovascular devices at the FDA, said last week. (
  • So-called drug-eluting metal stents relieved restenosis but patients lost some flexibility in vessels with metallic stents, small cylindrical mesh-like devices that become permanent implants. (
  • Data from the British Columbia Cardiac Registries during the mid-1990s show that restenosis occurs in about 15% of patients with stents. (
  • The stent is not indicated for the treatment of restenosis. (
  • It was used as a scaffold to prevent the vessel from closing and to avoid restenosis in coronary surgery-a condition where scar tissue grows within the stent and interferes with vascular flow. (
  • To further reduce the incidence of restenosis, the drug-eluting stent was introduced in 2003. (
  • A ureteral stent (pronounced you-REE-ter-ul), or ureteric stent , is a thin tube inserted into the ureter to prevent or treat obstruction of the urine flow from the kidney . (
  • Three-dimensional reconstructed CT scan image of a ureteral stent in the left kidney (indicated by yellow arrow). (
  • What's a Ureteral Stent? (
  • How Long Does a Ureteral Stent Stay In? (
  • How Is a Ureteral Stent Removed? (
  • A ureteral stent that's going to be in place for only a few days to a week usually has a string attached to the end of it. (
  • A ureteral stent sometimes can be uncomfortable and cause some blood in the pee . (
  • 1. A ureteral stent, comprising: an elongate body having a proximal end and a distal end and defining a lumen and an opening in communication with the lumen, the lumen having a diameter, the opening having a width greater than ½ the size of the diameter of the lumen and less than the diameter of the lumen, the opening having a length at least twice the width of the opening. (
  • 2. The ureteral stent of claim 1, wherein the elongate body defines at least one channel on an outer surface of the elongate body. (
  • 3. The ureteral stent of claim 1, further comprising: a retention member disposed at least one of the proximal end or the distal end of the elongate body, the retention member configured to help anchor the elongate body within a ureter. (
  • 4. The ureteral stent of claim 1, further comprising: a first retention member at the proximal end of the elongate body and a second retention member at the distal end of the elongate body, the first retention member configured to be disposed within a bladder, the second retention member configured to be disposed within a kidney. (
  • 6. The ureteral stent of claim 1, wherein the opening extends from the proximal end to the distal end of the elongate body. (
  • 7. The ureteral stent of claim 1, wherein the opening is configured to laterally receive a guidewire therethrough, the elongate body being configured to releasably couple the guidewire within the lumen of the elongate body such that the elongate body can be slidably moved along the guidewire. (
  • 9. The ureteral stent of claim 8, wherein the elongate body defines a plurality of channels on an outer surface of the elongate body. (
  • Do use code 50382 when a ureteral stent is removed and replaced percutaneously. (
  • Amplatz wire and coaxial placement of an 8 French ureteral stent (50393, 74480) is performed and the loop locked in the renal pelvis. (
  • Two days later the nephrostomy is removed under fluoroscopic guidance to avoid pulling out the ureteral stent (50389). (
  • Example 3) Thirty year old with fractured ureteral stent. (
  • A new ureteral stent is placed. (
  • In medicine , a stent is a metal or plastic tube inserted into the lumen of an anatomic vessel or duct to keep the passageway open, and stenting is the placement of a stent. (
  • Stent" is also used as a verb to describe the placement of such a device, particularly when a disease such as atherosclerosis has pathologically narrowed a structure such as an artery . (
  • Other types are duodenal stents, colonic stents, and pancreatic stents, the designations referring to the location of their placement. (
  • What Happens During the Placement of Cardiac Stents? (
  • What Happens After the Cardiac Stent Placement? (
  • Stent placement is part of more than 70% of interventional procedures. (
  • Stent placement is not considered major surgery and takes approximately one hour. (
  • In addition, a unique 360 degree kidney curl helps to achieve easier stent placement in the renal pelvis or a calyx. (
  • These stents ensure that the ureter does not spasm and collapse after the trauma of the procedure. (
  • The stent is removed by cystoscopy, an outpatient procedure. (
  • Your child won't be able to eat or drink for several hours before the cardiac stent procedure. (
  • Can I Stay With My Child During the Cardiac Stent Procedure? (
  • When a stent is placed into the body, the procedure is called stenting. (
  • Angioplasty became more popular when the first drug-coated stent came out that year, virtually eliminating the procedure\'s main drawback: scar tissue requiring a repeat effort to reopen the vessel. (
  • Manufacturers of stents for percutaneous coronary intervention (PCI) note that the Ischemia study also concluded that patients who undergo a stenting procedure have a better quality of life. (
  • These studies usually involve evaluation of a composite primary endpoint of cardiac death, myocardial infarction, and need for repeat procedure involving the lesion where the stent was placed. (
  • The GORE® Carotid Stent is used with a protection device (GORE® Embolic Filter) that filters blood flow at the treatment site to capture and remove particles that may come loose during the procedure. (
  • After the procedure, a campaign aide reported that Sanders "feels better than ever because that's how people feel after they get a stent and there's more blood flow. (
  • We don't know all the details, but this is a common, safe procedure, and with contemporary stents, it generally comes with a short recovery time," said Nissen, who wasn't involved in Sanders' care. (
  • In the time before stents became all the rage, cardiologists were cautious about the procedure, placing one or two stents at one sitting, but with experience the confidence of the interventionists grew and they began to insert as many as three stents at one sitting. (
  • In the procedure, an Accunet filter was deployed above the artery narrowing and an Acculink stent was placed. (
  • In addition to the use of simple balloon angioplasty, the availability of stents, in a wire-mesh design, have expanded the spectrum of people suitable for percutaneous coronary intervention, as well as enhanced the safety and long-term results of the procedure. (
  • Canic and Tambaca have also used the model to design a stent with mechanical properties specifically tailored to an experimental heart-valve replacement procedure. (
  • She found that this specialized stent works best for the procedure when it's stiff in the middle and less stiff at the ends. (
  • On the day prior to your treatment you may be asked to withhold some of your blood pressure medication so as not to interfere with the blood pressure response during the actual stent procedure. (
  • On the morning of the stent procedure, make sure you take aspirin and other blood thinning medication. (
  • Angioplasty is the procedure used for placing stents. (
  • Stents are place during a procedure called an angioplasty. (
  • Then the subjects had a procedure: a real or fake insertion of a stent. (
  • Those who got the sham procedure did just as well as those who got stents. (
  • Since the procedure carries some risks, including death, stents should be used only for people who are having heart attacks, she added. (
  • Doctors may place a stent if a blood vessel is too narrow for enough blood to pass through. (
  • While uncommon, damage to the blood vessel can happen and a stent can move from the correct place. (
  • The main purpose of a stent is to counteract significant decreases in vessel or duct diameter by acutely propping open the conduit by a mechanical scaffold or stent. (
  • Stents are inserted routinely now at angioplasty to improve the chances of keeping the vessel open. (
  • A coronary stent is an artificial support device placed in the coronary artery to keep the vessel open after treatment for coronary artery disease . (
  • Through a blood vessel in the groin, doctors push a tube to a blocked heart artery, inflate a balloon to flatten the clog, and prop the artery open with a stent. (
  • The term "stent" has come into widespread use to denote any of a large variety of spring-like support structures, in the form of a tube which is open at both ends, which can be implanted inside a blood vessel or other tubular body conduit, to help keep the vessel or conduit open. (
  • The stent remains permanently implanted in the neck artery and acts as a support for the newly opened section of the blood vessel. (
  • The stent opens blockages in the blood vessel in order to prevent future strokes. (
  • The apertured links and undulating links provide the stent with a high degree of flexibility in the longitudinal direction, yet the stent has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. (
  • A metal mesh tube (stent) is inserted into the vessel to serve as a scaffold that helps prevent the artery from narrowing again. (
  • A fully bio-absorbable coronary stent that scaffolds the vessel wall when needed and disappears once it has remodelled itself has theoretical advantages. (
  • For example, there's less potential for late stent blockage as there will be no foreign material exposed to the blood if the stent has disappeared into the vessel wall. (
  • 1. Match the stent size as closely as possible to vessel diameter. (
  • 4. Use proper technique to ensure that the stent is fully deployed and in contact with the vessel wall. (
  • Endovascular aortic aneurysm repair involves accessing the damaged aorta by first puncturing a blood vessel in the groin, often without making an incision, and then inserting a metallic stent that is guided using X-rays to the target area where it is then expanded. (
  • The first balloon expandable stents were designed from surgical grade stainless steel, and aimed to provide additional mechanical support, limiting vessel recoil and preventing acute occlusion [ 6 ]. (
  • Allium's self-expanding Biliary Stent has a large caliber (8-10mm in diameter) and is made of a superelastic alloy covered by a polymeric material. (
  • All indications related to the PROTÉGÉ GPS SELF-EXPANDING PERIPHERAL AND BILIARY STENT are not approved globally, please refer to the complete Instructions for Use manual for the indication for Use approved in your geography. (
  • The IntraStent™ Max™ LD biliary stent is your best choice for strength within the IntraStent family. (
  • A coronary artery stent is a small, metal mesh tube that expands inside a coronary artery. (
  • A wire mesh tube (stent) may then be placed in this blocked area. (
  • Cardiac stents are very small mesh wire tubes. (
  • The stent is usually a stainless steel mesh tube that is available in various sizes to match the size of the artery and hold it open after the blockage in the artery has been treated. (
  • Bare metal coronary stents - These are tubular, mesh-like devices that do not have any medications embedded in them. (
  • A stent is a small wire mesh tube used to open and support a narrowed artery, much like a scaffold. (
  • 2. The stent of claim 1 , wherein said mesh structure comprises at least one portion where said threads cross to define a crossing point, wherein said threads at said crossing point being configured to slide with respect to one another. (
  • 3. The stent of claim 1 , wherein said mesh structure comprises at least one portion where said threads cross to define an interlacing pattern. (
  • The researchers attached a tiny, flat pressure sensor to the stent and modified the pattern of the wire mesh so that it acts as an antenna. (
  • The stent is made of a nickel-titanium alloy (nitinol) tubing, laser-cut into a mesh shape, with an expanded polytetrafluoroethylene (ePTFE) lattice attached to its outer surface. (
  • Stents are tiny mesh tubes made from metal alloys that hold blood vessels open after they've been clogged with disease-causing plaque. (
  • The researchers studied 980 patients with type 2 diabetes who had undergone percutaneous cardiac intervention (PCI) to clear a blocked coronary artery and place a supportive mesh tube known as a stent. (
  • Eventually, arterial cells will cover the mesh of the stent with the inner layer looking like a normal blood pressure. (
  • Since the balloon is immediately deflated after maximal inflation during stent implantation and 80% of the expandable wire mesh of the stent was open surface opposing elastic recoil, the process minimized endothelial damage compared to balloon angioplasty alone [ 5 ]. (
  • The main complications with ureteral stents are dislocation, infection and blockage by encrustation. (
  • Besides failing to perform the job it was intended to do, a moved stent can lead to more serious problems like creating a blockage somewhere else in the body. (
  • The 78-year-old presidential hopeful received two stents to open the blockage. (
  • According to Weaver, "following medical evaluation and testing he was found to have a blockage in one artery and two stents were successfully inserted. (
  • That tube has the stent on the tip of a deflated balloon, which the cardiologist guides to the site of blockage. (
  • The stent stays within the artery to help prevent the artery from future blockage or narrowing. (
  • Angiplasty and stenting will be performed to reduce the blockage. (
  • One of the limitations of bare metal stents is that 30% of patients develop scar tissue that can cause re-blockage. (
  • Cardiologists said one reason might be that atherosclerosis affects many blood vessels, and stenting only the largest blockage may not make much difference in a patient's discomfort. (
  • 2. The stented valve of claim 1, wherein one of the first and second ends of the stent structure is curved outwardly relative to the longitudinal axis. (
  • 7. The stented valve of claim 4, wherein a central region of the stent structure between the first and second ends has a diameter than is larger than the diameter of both the first and second ends of the stent. (
  • For the first time in Ontario and only the second time in Canada, physicians performed a clinical angioplasty using a stent that completely dissolves over time. (
  • The stent used is the only bioabsorbable stent available for clinical use right now and is currently only available by special access from Health Canada. (
  • Peripheral vascular stents including bare metal, drug-eluting, covered and bioabsorbable stents are associated with improved clinical outcomes compared to balloon angioplasty alone. (
  • However, as clinical data and appropriate reimbursement and costs are established, adoption of innovative stent technologies such as drug-eluting stents and bioabsorbable stents will increase in the future. (
  • Peripheral stenting will continue to increase in the future given the rising prevalence of peripheral artery disease in the lower extremity and improved clinical outcomes compared to balloon angioplasty alone. (
  • Clinical end points in coronary stent trials: a case for standardized definitions. (
  • The EluNIR drug-eluting stent made by Medinol performed just as well as the Resolute Integrity or Resolute Onyx stents from Medtronic (NYSE:MDT), according to new clinical study results from an international team of researchers. (
  • One of my main roles at the FDA is to review proposed clinical trials to evaluate new stents as well as to assess the data submitted for FDA approval to allow marketing of a new stent in the United States. (
  • In a clinical study, the stent was implanted successfully in 265 out of 265 patients in the United States, with six (6) patients suffering a stroke. (
  • In a clinical study, which included 170 patients who had post-thrombotic syndrome or iliofemoral compression, approximately 84% of patients who received stents continued to have an open iliofemoral vein after one year. (
  • The researchers write that more study is needed before they can conclude strict glucose control after stenting will improve long-term clinical outcomes in people with diabetes. (
  • Dr. Luis Gruberg, who led clinical studies of the device at Stony Brook University Hospital, said the newly approved stent can't be used in all types of blockages. (
  • WellPoint Inc., the nation's second-largest health insurer, is considering coverage changes to better inform patients about elective stents' risks and benefits, said Alan Rosenberg, the company's vice president of medical and clinical pharmacy policy. (
  • Initial clinical trials of these drug-eluting stents have been completed and other trials are underway. (
  • Furthermore, it should be noted that in 1 major study that demonstrated the benefits of the CYPHER stent 7 the device was investigated in a limited clinical application. (
  • The stent, made by Abbott Laboratories in Illinois, just finished its first test-a two-year trial involving 30 patients-and now, after a few adjustments, the company is launching its next phase of clinical tests. (
  • The everolimus drug and fluorinated copolymer used on the PROMUS Element Stent have been studied in multiple randomized clinical trials and 'real-world' registries, demonstrating excellent long-term safety and efficacy. (
  • In the new study, researchers analyzed data on patients treated with both IV t-PA and stent retrievers from the Solitaire With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial to learn more about the clinical relevance of the duration of time from symptom onset to clot removal. (
  • Two possible clinical scenarios exist for patients with stents who have noncardiac surgery. (
  • U.S. clinical guidelines say stenting is appropriate for patients with a blocked artery and chest pain who have tried optimal medical therapy, meaning medications like those given to the study patients. (
  • FDA public health notification: complications from metallic tracheal stents in patients with benign airway disorders, 2005 (Accessed on January 15, 2007). (
  • Also, advancements in technology such as the introduction of bioabsorbable stents in the Indian market in December 2012 has made such stents more acceptable to patients, thereby providing further stimulus for market growth. (
  • The length of the stents used in adult patients varies between 24 and 30 cm. (
  • Most patients tolerate having the stent removed using only a topical anesthetic placed in the urethra. (
  • It is, "What are the relative advantages and disadvantages of the various treatments for patients with symptomatic coronary artery disease-medical therapy only, percutaneous transluminal angioplasty with stents, and coronary artery bypass grafting. (
  • They followed over 1700 patients who were judged appropriate for surgery or stenting or both for six years. (
  • He makes a persuasive case that multidisciplinary teams should be making recommendations to patients whether they should continue medical treatment or receive stents or surgery. (
  • Some patients are served well by stents but others require CABG. (
  • This new stent may turn out to be better for patients because there's no metal,' says Dr. Vlad Dzavik, deputy head, Division of Cardiology and Director of Interventional Cardiology Research, University Health Network. (
  • And a stent that is not there for a patient's lifetime might be especially useful in younger patients. (
  • Researchers want to learn more about this stent so that they can better understand which patients might benefit most from having this kind of a scaffold inserted. (
  • Doctors think these stents may raise the risk of life-threatening blood clots months and even years later unless people stay on Plavix, an anti-clotting drug whose long-term safety in stent patients has not been established. (
  • Two brands are sold in the United States - Taxus, by Boston Scientific Corp., and Cypher, by Johnson & Johnson\'s Cordis Corp. Labels say patients should take baby aspirin and Plavix for three months with Cypher and six months with Taxus, based on how long the stents release medication and how long doctors believed it took for the artery to repair itself by forming a new lining. (
  • This produced the bombshell finding that patients with coated stents had double the risk of cardiac problems after stopping Plavix than those with plain metal stents. (
  • Cleveland Clinic physician Tom Gildea developed the stents to keep open the airways of patients with serious breathing disorders caused by inflammation, trauma, tumors and other masses. (
  • Patients treated with coronary-artery bypass surgery survive about three years longer than those who have their blood vessels propped open with stents, researchers reported Sunday at the American Heart Association's annual meeting, in Chicago. (
  • The initial trial involved 1,900 patients who randomly underwent either stenting or bypass surgery between 2005 and 2010. (
  • We also ask for a smaller subset of patients with protocol-mandated angiography and intravascular ultrasound to assess healing responses and how well the stent is apposed to the artery wall, both immediately post-implantation and in the long term. (
  • Whenever my diabetic patients return to me after one of these procedures, I am struck by how routine stenting has become. (
  • I always give these stories the appropriate gasps in my office, my eyes hopefully reflecting my amazement, but I cannot help what my sagacious head exasperatedly takes note: that stents have made it seem like coronary artery disease, often a lethal and progressive condition, is endlessly manageable and stents have corrupted my patients' desire to change their life styles. (
  • like liquid Drano to the plumber, so the stents to the cardiologists, these patients imagine. (
  • A MidAtlantic cardiologist informs one of Midei's patients - an St. Joseph's employee - that his stent was unnecessary. (
  • Explain to interested patients that this preliminary study suggests using a neuroprotective filter when placing a stent in the carotid artery. (
  • Her work could help manufacturers optimize stent design and help doctors choose the right stents for their patients, ultimately improving patient outcomes. (
  • Allium's stents are cost effective and more acceptable to physicians and patients. (
  • For heart attack patients, a stent is the medical device that provides the best chance of recovery. (
  • A coronary stent that slowly dissolves over time - vanishing in the fashion of biodegradable sutures and absorbable bone screws - has won the approval of federal regulators for use in patients with cardiovascular disease. (
  • Pappas sees other possibilities: "This may be a good option for people who need multiple stents and with this type of platform, patients can avoid the layers and layers of metal. (
  • Eight studies have found stents are no better than drug-based therapy in preventing heart attacks and death in patients with stable heart disease. (
  • Insurers, too, are questioning whether doctors adequately inform patients about the risks of stenting or the benefits of alternatives. (
  • Insurer HealthNow New York Inc. brings extra review to cases in which patients seek elective stents under a pilot project in Buffalo that's aimed at steering them toward medicinal treatments instead, said Alan Saltzman, the company's medical director. (
  • Stents may provide less benefit to such patients, he said. (
  • You can call anything 'appropriate,'" said Boden, the principal investigator of the "Courage" study, the first large trial to cast doubt on stents' benefit for stable patients, in 2007. (
  • London, March 14 (IANS) Bio-absorbable stents are safe and effective in patients with single coronary artery lesions, according to this week's edition of The Lancet. (
  • Patrick Serruys of Erasmus Medical Center and John Ormiston of Auckland City Hospital studied 30 patients who had ischaemia and a single lesion, suitable for treatment with a single 3×12 mm or 3×18mm stent. (
  • Patients with heart disease could soon be treated without stents, thanks to tiny nanoparticles that can home in on damaged tissue and release drugs. (
  • For its initial test run, the stent was placed in patients with just a single narrowed or blocked artery. (
  • Because the stent was tested on so few people, however, and because those patients had very simple problems, it is difficult to know whether it will match the long-term success of its metal predecessors. (
  • Time from onset of symptoms to the initiation of clot removal averaged more than 4.5 hours for patients who initially arrived to a referring facility, compared with only 3 hours for patients who presented directly to an endovascular-capable center with stent- retriever services available. (
  • As a result, there is a significant variation in the regimens followed for patients on anticoagulation who have had a stent implanted, as was demonstrated in a survey among interventional cardiology centers worldwide. (
  • Noncardiac surgery performed in patients who have had recent coronary stenting exposes them to an increased risk of major cardiac events in the perioperative period, especially if the OAA therapy is interrupted. (
  • The petitioner allegedly colluded with dealers and purchased stents post expiry date, manipulated the expiry dates in invoices, used them for 10 patients who got treatment under the Tamil Nadu Government Comprehensive Health Insurance Scheme and claimed charges from the government. (
  • Therefore, SEMS should only be used in nonmalignant large airway disease as a last resort for patients in whom other endoscopic methods, including silicone stents and dilations, as well as surgical options have failed or are technically not feasible. (
  • Sometimes patients get stents when they have no pain at all, just blockages. (
  • More than 500,000 heart patients worldwide have stents inserted each year to relieve chest pain, according to the researchers. (
  • For the study, Dr. Justin E. Davies, a cardiologist at Imperial College London, and his colleagues recruited 200 patients with a profoundly blocked coronary artery and chest pain severe enough to limit physical activity, common reasons for inserting a stent. (
  • Neither the patients nor the researchers assessing them afterward knew who had received a stent. (
  • The stents did what they were supposed to do in patients who received them. (
  • But those guidelines were based on studies in which patients simply said they felt better after having stents inserted. (
  • Cordis Corporation today announced that a U.S. District Court jury in Wilmington, Delaware found that Boston Scientific's Taxus drug-eluting stent and its Liberte and Express bare metal stents infringe Cordis' pioneering Palmaz patent for balloon expandable stents, and that the bare metal Liberte stent also infringes another Cordis patent - the Gray patent - which relates to flexible balloon expandable stents and expires in 2016. (
  • The valuation of Global Bioabsorbable Stents Market is USD 395.5 million in 2016. (
  • The Bioabsorbable Stents market is estimated to reach USD 3.32 billion in 2022, growing at a CAGR of 42.60% between 2016 and 2022 according to this study. (
  • In this report, the global Intracranial Stents market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (
  • As with any medical device placed inside the body, certain complications can arise when a stent is inserted. (
  • This can cause serious complications, because the stent is no longer where it's supposed to be and it may not be performing its job once it has moved. (
  • The use of newer devices such as intracoronary stents and atherectomy , as well as newer pharmacologic agents has resulted in higher success rates, reduced complications, and reduced recurrence after percutaneous coronary intervention . (
  • Permanent metallic stenting can be susceptible to such blockages and other complications. (
  • Over the past few years, these complications have decreased with the widespread use of anticlotting therapies and drug eluting stents coated with immune suppressants. (
  • Reported complications include infection, granulation tissue formation, stent migration, stent fracture, airway perforation and fistula formation, as well as extension of the initial injury, potentially eliminating other therapeutic options such as surgical resection. (
  • Stent grafts are also used to treat stenoses in vascular grafts and fistulas used for hemodialysis . (
  • However, stent grafts are made of fabric. (
  • for example, about which stent grafts they use in their procedures,' she said. (
  • Researchers at the University of California, San Diego School of Medicine have documented the safety benefits of aortic stent grafts inserted during minimally invasive surgery to repair abdominal aortic aneurysms - weaknesses in the body's largest artery that can rupture, causing potentially lethal internal bleeding. (
  • This bioabsorbable stent, a polymer made from lactic acid, provides the structural support needed in the artery during and immediately following angioplasty. (
  • Bangalore S, Toklu B, Amoroso N, Fusaro M, Kumar S, Hannan EL, Faxon DP, Feit F. Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis. (
  • This novel microstructured polymer stents are made of a shape memory polymer (e.g. polyurethane). (
  • Below body temperature the shape memory polymer stent has a compressed geometry (temporary form, see left figure). (
  • When heating the shape memory polymer stent on body temperature the stent turns into an uncompressed geometry (predefined permanent form, see right figure). (
  • Therefore the polymer stent is a reliable device for angioplasty procedures. (
  • Orsiro is a cobalt-chromium stent that elutes the drug sirolimus via the Berlin-based company's Biolute bioabsorbable polymer coating. (
  • This paper provides evidence for the first time that instances of allergic reactions, presumably to the polymer in the stent, can occur," said study co-author Dr. Charles Bennett , an NMH epidemiologist and oncologist. (
  • They also concluded the polymer coating on the stent itself is the most probable cause of hypersensitivity in the majority of cases, rather than the medications the stent is coated with. (
  • A DES is a combination product consisting of 3 important individual components: the stent, the polymer, and the drug combined together in the finished product. (
  • The FDA needs information on how the stent performs, which starts with laboratory bench testing of the stent and polymer coating, which may be permanently affixed to the stent or may be intended to degrade over time, as well as some safety information about the drug component. (
  • Abbott's new bioabsorbable everolimus-eluting stent, or BVS, is made up of two layers of a biodegradable polymer: one that contains the immunosuppressant drug everolimus, the other forming a longer-lasting backbone. (
  • PTCA is now referred to as percutaneous coronary intervention, or PCI, as this term includes the use of balloons, stents, and atherectomy devices. (
  • Reason for posting: The use of coronary stents has improved the results of percutaneous coronary revascularization procedures. (
  • The National Coverage Determination (NCD) for Percutaneous Transluminal Angioplasty (PTA) covers carotid artery stenting (CAS) procedures under certain circumstances including through study participation. (
  • So from a percutaneous approach, the kidney was accessed and through a sheath, the uretural stent was removed using an Amplatz snare. (
  • The development of stents to treat CAD was a significant innovation, facilitating effective percutaneous coronary revascularization. (
  • Aspirin can help decrease the possibility of blood clots forming at the stent. (
  • Even though stents are designed to be compatible with the human body, they sometimes cause unwanted reactions, such as blood clots and scar tissue formation. (
  • Imaged via ultrasound two years after surgery, this artery shows no trace of the bioabsorbable stent used to prop it open. (
  • A stent graft or covered stent is type of vascular stent with a fabric coating that creates a contained tube but is expandable like a bare metal stent . (
  • Through GlobalData's analysis, it is evident that currently the peripheral vascular stent market for the lower extremity is saturated with bare metal stents, followed by covered stents. (
  • Q).As more bioabsorbable stents receive approval, how will new entrants impact the peripheral vascular stent market for the lower extremity? (
  • The authors concluded: "This study shows the feasibility of implantation of the bio-absorbable everolimus-eluting stents. (
  • A fixed amount of sirolimus per unit area is applied to the CYPHER stent, which is designed to release about 80% of the drug within 30 days of implantation. (
  • He was an ex-smoker, and his only previous medical history was of an acute coronary syndrome leading to the implantation of a drug-eluting stent (DES) in his proximal left anterior descending artery 3 months before this admission. (
  • The first is the situation in which a patient requires noncardiac surgery and, as a result of a preoperative coronary risk assessment, undergoes an angiogram with subsequent stent implantation before the surgery is scheduled. (
  • Bare-metal stent: This is a stent made of metal that is placed in the artery to help hold it open. (
  • As Ariel Roguin describes in his paper "Stent: The Man and Word Behind the Coronary Metal Prosthesis", the current acceptable origin of the word stent is that it derives from the name of a dentist, Charles Thomas Stent , notable for his advances in the field of denture-making. (
  • Traditional stents are made of metal, which can complicate bypass surgery if the patient needs that in the future. (
  • Dr. Dzavik is quick to point out that this does not make metal stents obsolete. (
  • Metal stents can save the life of a patient having a heart attack and can stop the angina of a patient with more chronic symptoms. (
  • Q).How will adoption of these stent technologies affect adoption of bare metal and covered stents? (
  • The PVS market is currently dominated by bare metal stents, specifically self-expanding nitinol stents. (
  • These are tubular devices made up of special fabric that is supported by a rigid metal stent. (
  • These gizmos, called drug-coated stents, worked so much better than plain old metal ones that 6 million people worldwide received them in the few years they have been available. (
  • Many are returning to the old metal stents, and some are fundamentally rethinking when to use stents at all and are considering alternatives like bypass surgery or medications. (
  • Compared with bare metal uncoated stents, DES are associated with a lower rate of repeat revascularization procedures. (
  • We are confident that the finding of infringement of the Gray patent by the bare-metal Liberte stent will also apply to the drug-eluting version of Liberte, and Cordis will strongly assert its patent claim against it if and when the product is launched," said Nick Valeriani, Worldwide Chairman, Cardiovascular Devices and Diagnostics. (
  • I have 8 med stents fully lining in my LCA forming a full metal jacket And two others in a. (
  • 14. The stent of claim 1 , wherein the stent is formed from a pseudo elastic metal alloy. (
  • Allium's thin-walled, large caliber, self-expanding, fully covered metal stents are unique because they can be left in the body for long periods without being changed and easily removed even after long implant periods. (
  • Metal stents have evolved from bare metal devices two decades ago to metal scaffolds in more recent years that are coated in medication to prevent reclogging. (
  • The CYPHER stent, a metal device that is coated with sirolimus, was approved in April 2003 by the US Food and Drug Administration (FDA) for use in angioplasty procedures. (
  • The national drug price regulator had in February 2018 marginally increased the price of bare metal stents (BES) from ₹ 7,260 to ₹ 7,660, and reduced prices of drug-eluting and biodegradable stents from ₹ 29,600 to ₹ 27,890. (
  • Bare metal stents sold for as much as ₹ 45,000 and drug-eluting stents cost ₹ 1.21 lakh prior to the imposition of the cap in February 2017. (
  • But some cardiologists still liken the use of metal stents to leaving a cast in place once a person's broken limb has healed. (
  • Because metal stents have proven to be so effective, some question whether a bioabsorbable version is worth the research investment, especially since the bar to prove both safety and efficacy is set so high, and since there's not yet proof that the disappearing stent doesn't leave scarred tissue in its wake. (
  • A stent is a small rod made out of metal or fabric. (
  • Drug-eluting stent: A drug-eluting stent is a metal stent that is coated in medicine. (
  • Coronary stents have evolved from bare metal compositions, to incorporate advances in pharmacological therapy in what are now known as drug eluting stents (DES). (
  • Improved results were observed following the insertion of an additional intravascular mechanical support, cylindrical metal scaffolds known as stents [ 5 ]. (
  • There is a wide variety of stents used for different purposes, from expandable coronary , vascular and biliary stents, to simple plastic stents used to allow the flow of urine between kidney and bladder . (
  • Stents may be self-expanding or balloon expandable and can be made from various materials including stainless steel, Elgiloy, tantalum, Nitinol or polymers. (
  • Today's findings of infringement against the Taxus, Liberte and Express stents - together with previous findings of infringement by Boston Scientific's NIR stent - reinforces the strength of Cordis' deep patent estate on balloon expandable stents. (
  • The composite device includes an elongate radially expandable tubular stent having an interior luminal surface and an opposed exterior surface extending along a longitudinal stent axis. (
  • A stent cover is formed of unsintered ePTFE which is expandable. (
  • 2. A composite intraluminal device of claim 1 wherein said stent is radially expandable from a first compressed state permitting intraluminal delivery to a second expanded state permitting intraluminal deployment. (
  • The invention is directed to an expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. (
  • created a balloon-expandable stent that is currently used. (
  • Shortly thereafter, in 1987, Julio Palmaz (known for patenting a balloon-expandable stent ) and Richard Schatz implanted their similar stent into a patient in Germany. (
  • The stent is almost always coated with a drug (called a drug-eluting stent). (
  • c) after said coiled spring has cooled sufficiently, reversing the winding direction of said coiled spring to form the stent. (
  • The Global Intracranial Stents Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Intracranial Stents industry. (
  • The stent is left there to help keep the artery open. (
  • A cardiac angiography will follow to ensure that the stent is keeping the artery open. (
  • A stent will help hold the artery open so blood can flow. (
  • Stents are implanted devices used to prop open various types of body passageways such as blood vessels, bile ducts, urinary tracts and even the esophagus. (
  • Stents are used to open blockages in a tubule structure. (
  • The stent holds the structure open. (
  • A urinary stent is used to hold the ureter open in cases where it has narrowed. (
  • This stent is used to open up the narrowing caused by an enlarged prostate pushing against a man's urethra and preventing the normal outflow of urine. (
  • The stent helps to keep the urethra open so that urine can flow from the bladder out of the body. (
  • Stents can also be used to keep the food pipe of the esophagus open in case of esophageal constriction and biliary stents can be used to maintain adequate drainage of bile into the intestine. (
  • Their stents are still fully open. (
  • wherein a first end of each leaflet is attached to a commissure wire in the central stent region and a second end of each leaflet is attached to an adjacent commissure wire in the central stent region so that the free edge of each leaflet does not contact the structural wires in the central stent region when the valve is in an open position. (
  • The stent increases blood flow from the leg by holding the iliofemoral vein wall open. (
  • After careful positioning, your doctor will open the stent to cover the plaque. (
  • Whether conventional or biodegradable, stents prop open blood vessels to restore blood flow, providing relief from blockages caused by biological goo - plaque that has collected over years. (
  • After you return home, you'll need to take medicine that keeps the stent open and blood flowing. (
  • Stents, like the one pictured here, are then put in place to keep the new passageways open in the lungs. (
  • UroPass II Open Tip Ureteral Stents have all the advantages and benefits of the UroPass. (
  • According to the author, from the use of Stent's compound as a support for facial tissues evolved the use of a stent to hold open various body structures. (
  • Because of the external compression and mechanical forces subjected to these locations, flexible stent materials such as nitinol are used in a majority of peripheral stent placements. (
  • A stent can cause the body to react defensively, creating mucous build-up, inflammation of surrounding tissues and organs, narrowing of the blood vessels around it (stenosis), abnormal tissue build-up and infection. (
  • Using their simplified model, the researchers have examined the designs of several stents on the market to see which structures seem to be best for specific blood vessels or procedures. (
  • The team believes this easy-to-harvest tissue will make stents more biocompatible, though they don't yet know how ear cartilage cells grow or behave in environments like human blood vessels. (
  • Your doctor will insert the Carotid Stent System through the vessels to the area of the plaque. (
  • 2. Use stents in previously untreated vessels only. (
  • Stents have been used to treat blocked coronary vessels for some time now, but the urinary tract in foetuses is much narrower in comparison. (
  • Ureteral stents are used to ensure the patency of a ureter , which may be compromised, for example, by a kidney stone . (
  • There is a kidney stone in the pyelum of the lower pole of the kidney (higher red arrow) and one in the ureter beside the stent (lower red arrow). (
  • In many cases these tumors are inoperable and the stents are used to ensure drainage of urine through the ureter. (
  • A urinary stent can be placed inside the ureter to allow the urine to flow out. (
  • Conventional stenting has already changed the treatment of cardiovascular disease worldwide over the past two decades and in this country has led to the expansion of hospital cardiology departments and the specialty of interventional cardiology. (
  • Three interventional cardiologists -- doctors who insert stents -- have been convicted of federal fraud charges related to unnecessary stents and sentenced to prison since 2008. (
  • It really looks like the stent did its job of stopping re-narrowing, it was safe, and it disappeared," says John Ormiston , lead researcher of the Lancet study and an interventional cardiologist at Mercy and Auckland City Hospitals in New Zealand. (
  • It's a very humbling study for someone who puts in stents," said Dr. Brahmajee K. Nallamothu, an interventional cardiologist at the University of Michigan. (
  • Depending on the severity of the disease, the main interventional options for revascularisation include angioplasty, stent deployment and in severe, diffuse occlusions (more than 70%), bypass graft surgery [ 3 ]. (
  • Bioresorbable stent Bronchoscopy Colonoscopy Esophagogastroduodenoscopy Grommet Interventional radiology Health, Center for Devices and Radiological. (
  • 18. The stent of claim 1 , wherein the body has a tubular configuration. (
  • The stented valve further includes a valve structure attached within the generally tubular portion. (
  • The stent has a tubular shape to fit the common bile duct anatomy combined with a specially designed proprietary element on its ends to minimize reactive tissue proliferation. (
  • Covered stents are used in endovascular surgical procedures such as endovascular aneurysm repair . (
  • Peripheral stents are main devices used in endovascular treatment for peripheral vascular diseases. (
  • Endovascular therapies such as stenting have been widely adopted to treat peripheral artery disease in the lower extremity. (
  • Reflow Medical announced yesterday that its Temporary Spur Stent system for treating below-the-knee peripheral artery disease (PAD) won FDA breakthrough device designation. (
  • Stenting or CABG is determined by the number of blockages, the severity and their location(s). (
  • If blockages are found and stents are needed, it will normally be done at that time. (
  • My husband had the same stenting, and it is very rare to develop blockages in this area, but obviously it happens. (
  • So I suppose in the majority of people, stents won't be harmed by smoking, but 'research' tells us it will cause other blockages elsewhere. (
  • Mao H., Bao J., Liu G. (2018) Peripheral Stent. (
  • Stents are beneficial in such cases, most cardiologists agree. (
  • Guidant (NYSE:GDT) and Medtronic (NYSE:MDT) are also developing drug-coated stents for possible 2005 introduction. (
  • Reuters Health) - For people with type 2 diabetes, maintaining good blood sugar control in the years after receiving a coronary artery stent is associated with a lower risk of heart attack and stroke, according to a recent study. (
  • Dr. Rabbe was reporting an interim analysis of the Carotid Artery Stenting with Protection Study, which was intended to see whether using the neuroprotective device -- essentially a small net inserted above the stent to keep fragments of plaque from getting to the brain -- would prevent cognitive impairment. (

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