Activities performed by humans.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
The protection, preservation, restoration, and rational use of all resources in the total environment.
Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.
Large natural streams of FRESH WATER formed by converging tributaries and which empty into a body of water (lake or ocean).
The study of the origin, structure, development, growth, function, genetics, and reproduction of organisms which inhabit the OCEANS AND SEAS.
The effect of GLOBAL WARMING and the resulting increase in world temperatures. The predicted health effects of such long-term climatic change include increased incidence of respiratory, water-borne, and vector-borne diseases.
The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)
The variety of all native living organisms and their various forms and interrelationships.
The longterm manifestations of WEATHER. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.
The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.
Woody, usually tall, perennial higher plants (Angiosperms, Gymnosperms, and some Pterophyta) having usually a main stem and numerous branches.
Number of individuals in a population relative to space.
The science, art or practice of cultivating soil, producing crops, and raising livestock.
A great expanse of continuous bodies of salt water which together cover more than 70 percent of the earth's surface. Seas may be partially or entirely enclosed by land, and are smaller than the five oceans (Atlantic, Pacific, Indian, Arctic, and Antarctic).
A partially enclosed body of water, and its surrounding coastal habitats, where saltwater from the ocean mixes with fresh water from rivers or streams. The resulting mixture of seawater and fresh water is called brackish water and its salinity can range from 0.5 to 35 ppt. (accessed
Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.
Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.
The flow of water in enviromental bodies of water such as rivers, oceans, water supplies, aquariums, etc. It includes currents, tides, and waves.
The enrichment of a terrestrial or aquatic ECOSYSTEM by the addition of nutrients, especially nitrogen and phosphorus, that results in a superabundant growth of plants, ALGAE, or other primary producers. It can be a natural process or result from human activity such as agriculture runoff or sewage pollution. In aquatic ecosystems, an increase in the algae population is termed an algal bloom.
Water containing no significant amounts of salts, such as water from RIVERS and LAKES.
The circulation of nitrogen in nature, consisting of a cycle of biochemical reactions in which atmospheric nitrogen is compounded, dissolved in rain, and deposited in the soil, where it is assimilated and metabolized by bacteria and plants, eventually returning to the atmosphere by bacterial decomposition of organic matter.
The period of history before 500 of the common era.
The external elements and conditions which surround, influence, and affect the life and development of an organism or population.
Communications using an active or passive satellite to extend the range of radio, television, or other electronic transmission by returning signals to earth from an orbiting satellite.
A process by which animals in various forms and stages of development are physically distributed through time and space.
The branch of science concerned with the interrelationship of organisms and their ENVIRONMENT, especially as manifested by natural cycles and rhythms, community development and structure, interactions between different kinds of organisms, geographic distributions, and population alterations. (Webster's, 3d ed)
The scientific study of past societies through artifacts, fossils, etc.
Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The ceasing of existence of a species or taxonomic groups of organisms.
Contamination of the air, bodies of water, or land with substances that are harmful to human health and the environment.
Environments or habitats at the interface between truly terrestrial ecosystems and truly aquatic systems making them different from each yet highly dependent on both. Adaptations to low soil oxygen characterize many wetland species.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
Places for cultivation and harvesting of fish, particularly in sea waters. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.
A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)
The state of the ATMOSPHERE over minutes to months.
Non-native organisms brought into a region, habitat, or ECOSYSTEM by human activity.
The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.
The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)
The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)
Total mass of all the organisms of a given type and/or in a given area. (From Concise Dictionary of Biology, 1990) It includes the yield of vegetative mass produced from any given crop.
A climate which is typical of equatorial and tropical regions, i.e., one with continually high temperatures with considerable precipitation, at least during part of the year. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The sequence of transfers of matter and energy from organism to organism in the form of FOOD. Food chains intertwine locally into a food web because most organisms consume more than one type of animal or plant. PLANTS, which convert SOLAR ENERGY to food by PHOTOSYNTHESIS, are the primary food source. In a predator chain, a plant-eating animal is eaten by a larger animal. In a parasite chain, a smaller organism consumes part of a larger host and may itself be parasitized by smaller organisms. In a saprophytic chain, microorganisms live on dead organic matter.
Water particles that fall from the ATMOSPHERE.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Computer systems capable of assembling, storing, manipulating, and displaying geographically referenced information, i.e. data identified according to their locations.
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
Genotypic differences observed among individuals in a population.
A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)
The relationships of groups of organisms as reflected by their genetic makeup.
Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.
The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.
The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.
A country spanning from central Asia to the Pacific Ocean.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
In thermodynamic terminology, human economic activity may be described as a dissipative system, which flourishes by consuming ... Moreover, many economic activities result in the formation of structures. Thermoeconomics applies the statistical mechanics of ... Thermoeconomists maintain that human economic systems can be modeled as thermodynamic systems. Thermoeconomists argue that ... Thermoeconomics can be thought of as the statistical physics of economic value and is a subfield of econophysics. ...
"Non-random fluctuations and multi-scale dynamics regulation of human activity". Physica A: Statistical Mechanics and Its ... Actigraphy is a non-invasive method of monitoring human rest/activity cycles. A small actigraph unit, also called an actimetry ... however it is not provided with measures for brain activity (EEG), eye movements (EOG), muscle activity (EMG) or heart rhythm ( ... Activity actigraphs are worn and used similarly to a pedometer: around the waist, near the hip. They are useful for determining ...
"District Human Development Report Paschim Medinipur, 2011". pages 4-5. Department of Planning and Statistics, Government of ... Seva Bharati Krishi Vigyan Kendra is engaged in various activities benefitting and improving the farming community. Bangiya ... CS1 maint: discouraged parameter (link) "District Statistical Handbook Paschim Medinipur, 2013". Table 2.2, 2.4 (a). Department ... It is rather succinctly described in the District Human Development Report, 2011 (at that time it was part of Paschim Medinipur ...
"Propagation of EEG activity in beta and gamma band during movement imagery in human". Methods Inf. Med. 44 (1): 106-113. doi: ... usually understood as statistical dependencies) and effective connectivity (referring to causal interactions). Neuroanatomical ... Stam, C. J.; Suffczynski, P.; Lopes da Silva, F. H.; Lopes Da Silva, FH (1999). "Dynamics of the human alpha rhythm: evidence ... Consider the very common situation that the activity from a given source is measured at electrodes positioned at different ...
Human resource planning and forecasting, budgetting, report-writing and dissemination, are some of the activities that occur ... The unit provides statistical an epidemiology support to the entire institute. (2) Immunisable Diseases Unit, carries out ... Remi N. Charrel; Xavier de Lamballerie; Ali Mohamed Zaki (2008). Yichen Lu; M. Essex; Bryan Roberts (eds.). Human Cases of ... Most recently, UVRI has been involved in human HIV vaccine clinical trials. The HIV/AIDS Reference and Quality Assurance ...
This work with Jane Elith is useful in determining changes in biodiversity resulting from human activities. Her paper on niche ... Catherine H. Graham is most noted for her analysis of statistical models to describe species' distributions (Species ...
... to ensure human rights and freedoms related to their activities, to prevent their violation; to ensure informing the state ... as well as statistical recording of quarantine diseases in animals; to investigate phytosanitary situation in the country and ... According to direction of activity determined by this Regulation, responsibilities of agency are as follows: to analyze the ... to protect the population from diseases which are common to humans and animals in a manner determined by law; to prepare and ...
Arolithos village, Ktima Kares and Agrotikon are the most visited sites for this and other leisure activities. Also nearby is ... Excavation finds have included a pithos with Linear A inscriptions, stone horns, and clay human and animal figurines. There are ... area and average elevation)" (PDF) (in Greek). National Statistical Service of Greece. Jones, Donald W. 1999 Peak Sanctuaries ... ΜΟΝΙΜΟΣ Πληθυσμός" (in Greek). Hellenic Statistical Authority., "Mycenaean Greek and Linear B", Palaeolexicon ...
"Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression" ( ... Statistical tests pinpointed this gender-specificity to the right amygdala and strongest in the superficial nuclei. Since no ... of another person has been found in humans. A study from 2013 provided brain imaging evidence that human responses to fear ... In humans and other animals, fear is modulated by the process of cognition and learning. Thus, fear is judged as rational or ...
It conducts statistical activities in support of the research, analysis, and evaluation of programs to meet the needs of an ... The Administration on Aging (AoA) is an agency of the United States Department of Health and Human Services. AoA works to ... The Assistant Secretary reports directly to the Secretary of Health and Human Services. Lance Allen Robertson was confirmed in ... such as accomplishing essential activities of daily living, like getting to the doctor's office, buying groceries etc.) and ...
Many of those who experience ASMR report that non-vocal ambient noises performed through human activities are also effective ... this statistic is reflected in the popularity of intentional ASMR videos that comprise someone speaking in a whispered voice. ... In many cases, microphones are separated the same distance as ears are on humans, and microphones are surrounded by ear-shaped ... The first study to perform fMRI brain activity imaging on subjects experiencing ASMR (as opposed to merely those able to ...
Gershenzon, Naum I.; Ioshikhes, Ilya P. (2005-04-15). "Synergy of human Pol II core promoter elements revealed by statistical ... A replacement of the Adenosine nucleotide at the +1 to G or T changes transcription activity by 10% and a replacement of ... "Prevalence of the Initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA- ... Inr in humans was first explained and sequenced by two MIT biologists, Stephen T. Smale and David Baltimore in 1989. Their ...
The HSH2D protein has been studied along other human genes predicted to be involved in the human immune system. HSH2D was found ... The protein is also associated with alpha-interferon activity. HSH2D has four distant paralogs and several orthologs in other ... Brendel, V., Bucher, P., Nourbakhsh, I.R., Blaisdell, B.E. & Karlin, S. (1992) "Methods and algorithms for statistical analysis ... The four paralogs of HSH2D in humans are other proteins containing SH2 domains. They do not have a high level of conservation ...
Demography is the statistical study of all human populations. Development studies a multidisciplinary branch of social science ... Psychology also refers to the application of such knowledge to various spheres of human activity, including problems of ... Environmental geography combines physical and human geography and looks at the interactions between the environment and humans ... executing and controlling activities. Marketing the identification of human needs and wants, defines and measures their ...
She now focuses on how marine fish communities are affected for good or ill by human activities, such as resource extraction or ... Meeuwig has analysed the data from a similar scheme in Queensland and found no statistical evidence that it has proved ... Professor Meeuwig's PhD research was on the subject of statistical modelling of aquatic ecosystems. ... including the application of novel statistical approaches to understanding catch and effort data. On moving to Perth, Meeuwig ...
As a mathematical foundation for statistics, probability theory is essential to many human activities that involve quantitative ... Al-Kindi (801-873) made the earliest known use of statistical inference in his work on cryptanalysis and frequency analysis. An ... During that time, the connection between proability and statistic was established, thereby also connecting to the field of ... The early form of statistical inference were developed by Arab mathematicians studying cryptography between the 8th and 13th ...
It also handles publication matters and organises human resources development activities for statistical grade staff; c. ... The work of C&SD can be classified into three categories: Conducting statistical surveys and operating statistical systems for ... C&SD together with statistical units established in various government departments and bureaux form the Government Statistical ... Performing statistical analysis and disseminating statistical data and analytical results; and Providing consultation and ...
The main economic activities are cattle raising, and subsistence farming. The GDP was R$20,127,000 (2005). There was 01 banking ... The score on the Municipal Human Development Index was 0.615 (medium). This ranked Palmópolis 811 out of 853 municipalities in ... Palmópolis belongs to the Almenara statistical microregion. The elevation of the municipal seat is 600 meters. It became a ...
His research activities are in statistical machine translation, natural language processing and machine learning where he has ... "About Franz Och". Human Longevity, Inc. Archived from the original on 8 August 2014. Retrieved 4 August 2014. CS1 maint: ... J. Och: Statistical Machine Translation: From Single-Word Models to Alignment Templates. Diss. RWTH Aachen 2002. Works by or ... Prior to this, he was Head of Data Science at "Grail", (an Illumina company), Chief Data Scientist at Human Longevity Inc., and ...
... famous for describing human behaviour from a zoological perspective in his books The Naked Ape and The Human Zoo. Luboš Motl ( ... He is best remembered for the Mahalanobis distance, a statistical measure and for being one of the members of the first ... If we do this, we are forced to the conclusion that, in a behavioural sense, religious activities consist of the coming ... Such a world view starts from the axiom that humans will not be able to understand the world around them. There is no further ...
These technologies have also increased the ability to determine how human activities have impacted animal habitat and climate ... Alpha may be tested for a significant deviation from 1 by computing the test statistic χ 2 n 2 = 2 n α {\displaystyle \chi _{2n ... The natural world has become increasingly fragmented due to human activities; anthropogenic landscape change has had a ripple- ... Regardless of method, the sample size must be appropriate to the scale and the spatial statistical method used in order to be ...
This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other ... This means that a series of processing steps must be performed on the acquired images before the actual statistical search for ... The effect of this elevated activity during rest was to reduce, eliminate, or even reverse the sign of the activity during task ... This generates variations in neural activity from trial to trial within a subject. Across people too neural activity differs ...
The main economic activities are cattle raising and farming. There is still some mining of semi-precious stones. The GDP was R$ ... The score on the Municipal Human Development Index was 0.660. This ranked Rubelita 708 out of 853 municipalities in the state, ... Rubelita belongs to the Salinas statistical microregion. The elevation of the municipal seat is 438 meters. It became a ...
Neuropsychologists have also studied electrical activity in individual brain cells (or groups of cells) in humans and other ... This type of research is highly dependent on statistical methods. The number of proposed traits has varied; however, there is ... Social psychology is concerned with how humans think about each other and how they relate to each other. Social psychologists ... Developmental psychology is concerned with the development of the human mind and behavior over the life course. Developmental ...
The District Human Development Report for Malda notes, "Malda district has been a principal recipient of the human migration ... "District Statistical Handbook". Malda - Table 2.3 Growth of Population by sex on different census years in the district of ... Other workers are persons engaged in some economic activity other than cultivators, agricultural labourers and household ... As per the Human Development Report for Malda district, published in 2006, the percentage of rural families in BPL category in ...
Human habitation of the Silverton area extends back approximately 6,000 years before the present. In historical times, the ... Farming was Silverton's first major industry, and has been a dominant land-use activity in and around Silverton since the mid- ... Silverton is part of the Salem Metropolitan Statistical Area, and the population core of the Silver Falls School District. The ...
The main economic activities are cattle raising, and subsistence farming. The GDP was R$15,723,000 (2005). There were no ... Rio do Prado belongs to the Almenara statistical microregion. The elevation of the municipal seat is 350 meters. It became a ... The score on the Municipal Human Development Index was 0.626 (medium). This ranked Rio do Prado 793 out of 853 municipalities ...
Data are required for the smooth process of running communal human activities and are an important enabler of socio-economic ... Statistical literacy benefits from open data. Instructors can use locally relevant data sets to teach statistical concepts to ... The Human Genome Project was a major initiative that exemplified the power of open data. It was built upon the so-called ... While the human abstraction of facts from paper publications is normally accepted as legal there is often an implied ...
Demography is the statistical study of all human populations.. *Development studies a multidisciplinary branch of social ... Psychology also refers to the application of such knowledge to various spheres of human activity, including problems of ... The goal of anthropology is to provide a holistic account of humans and human nature. This means that, though anthropologists ... Environmental geography combines physical and human geography and looks at the interactions between the environment and humans. ...
For instance, human beings seem to have an enormous capacity for memorizing and recognizing faces. One of the key goals of ... The statistical mechanics of such simple systems are well-characterized theoretically. There has been some recent evidence that ... Models of working memory, relying on theories of network oscillations and persistent activity, have been built to capture some ... These are the bases for some quantitative modeling of large-scale brain activity.[35] ...
of Health and Human Services (US HHS). May 2002. Archived from the original on 2005-12-08. Retrieved 2006-07-11.. Cite journal ... Science-based medicine, with its emphasis on controlled study, proof, evidence, statistical significance and safety is being ... such as those which include all physical activity under the umbrella of "alternative medicine". ... Some alternative practices are based on theories that contradict the science of how the human body works; others resort to the ...
Wainer H (2014). Medical Illuminations: Using Evidence, Visualization and Statistical Thinking to Improve Healthcare. Oxford ... Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase, ( ... As a significant human pathogenic bacterium S. pneumoniae was recognized as a major cause of pneumonia in the late 19th century ... pneumoniae can be found in the human upper respiratory system. A study of competition in vitro revealed S. pneumoniae ...
Statistical, likelihood-based approaches: Statistical, likelihood-based [37][38] iterative expectation-maximization algorithms ... 2003). "FDG-PET imaging of lower extremity muscular activity during level walking". J Orthop Sci. 8 (1): 55-61. doi:10.1007/ ... PET technology can be used to trace the biologic pathway of any compound in living humans (and many other species as well), ... Proceedings Amererican Statistical Computing: 12-18.. *^ Snyder, D.L.; Miller, M.I.; Thomas, L.J.; Politte, D.G. (1987). "Noise ...
Nietzsche, Friedrich (1910). Human, All Too Human (PDF). Translated by Zimmern, Helen. Edinburgh: T. N. FOULIS. p. 355. ISBN ... indicate that much incorrect self-assessment of competence derives from the person's ignorance of a given activity's standards ... the philosopher Friedrich Nietzsche (1844-1900), who wrote in Human, All Too Human (aphorism 483), "The Enemies of Truth. - ... "Organizational Behavior and Human Decision Processes. 105 (1): 98-121. doi:10.1016/j.obhdp.2007.05.002. PMC 2702783 . PMID ...
Baumslag, Naomi (2005). Murderous Medicine: Nazi Doctors, Human Experimentation, and Typhus. Praeger Publishers. ISBN 0-275- ... "inevitable that a bureaucracy-no matter how decentralized its apparatus or how unplanned its activities-should push its victims ... "Statistical Report on the "Final Solution", known as the Korherr Report of 23 March 1943" (PDF). Die Endlösung by Gerald ... To have coped with this and-except for cases of human weakness-to have remained decent, that has made us tough. This is an ...
Physical activity[edit]. When combining exercise with exposure to loud noises, humans have been observed to experience a long ... Statistical analysis yielded a correlation between exposure of higher-frequency sounds to lower temporary threshold shifts and ... Physical activity also results in an increase in metabolic activity, which has already been increased as a result of the ... Human[edit]. A study conducted in Japan reports fatigue sensation shown in subjects who listened to a metronome for six minutes ...
One research team found a correlation in male fruit flies and discussed it as a possibility in other species, even humans.[35] ... and the activity of sendide (the peptide based NK1RA) against cisplatin-induced emesis in the ferret.[75] It is likely that ... "Measurement of plasma-derived substance P: biological, methodological, and statistical considerations". Clinical and Vaccine ... Palma C, Maggi CA (2000). "The role of tachykinins via NK1 receptors in progression of human gliomas". Life Sciences. 67 (9): ...
"Statistical Summary (Autumn 2018)". Ohio State University. Retrieved February 10, 2019.. ... It was a center of student life for more than 50 years, providing facilities for student activities, organizations and events ... College of Education and Human Ecology College of Engineering College of Food, Agricultural, and Environmental Sciences ... During this time, student activities were relocated to Ohio Stadium and other academic buildings.[68] ...
North Dakota Department of Human Services. State of North Dakota.. *^ NHS Leeds West CCG Assurance Committee (2014-01-02). " ... The activity of these nerves, or rather their fibers, may become excited or allayed by impingement, the result being a ... as opposed to statistical association) between cervical manipulative therapy (CMT) and VAS.[148] There is insufficient evidence ... exerted via the human nervous system and is a primary underlying risk factor for many diseases.[36] Straights view the medical ...
However, a 2006 study funded by DARPA found that CX717 did not improve cognitive performance in humans subjected to simulated ... "Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy". PLoS ONE. 5 (1): e8766 ... CX717 had demonstrated positive clinical and statistical results on the primary endpoint, the ADHD rating scale and the sub- ... and demonstrated that it can be used in humans alongside opioid drugs to reduce this side effect without affecting analgesia. ...
"Human Trafficking and Prostitution , Essay Examples". Essay Examples. 2018-03-15. Retrieved 2018-04-03.. ... CSEC includes child sex tourism and other forms of transactional sex where a child engages in sexual activities to have key ... who constituted the final statistical sample, the average age of entry into the market was 15.29. ... A national campaign in Thailand provided "9 years of basic education, ... awareness-raising activities to change attitudes ...
"The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor ... these follow-up studies lacked the sample size and statistical power to make any definitive conclusions, due to the rarity of ... RNA polymerase II transcription factor activity, sequence-specific DNA binding. • transcriptional activator activity, RNA ... In humans, PR is encoded by a single PGR gene residing on chromosome 11q22,[5][6][7] it has two isoforms, PR-A and PR-B, that ...
Statistical methods commonly used in other areas of psychology are also used in OHP-related research. Statistical methods used ... Human Relations, 14, 3-38. doi:10.1177/001872675100400101 *^ Kornhauser, A. (1965). Mental health of the industrial worker. New ... Hitchcock, E. (2008). NIOSH OHP activities. Newsletter of the Society for Occupational Health Psychology, 3, 10. [13] ... 2012). Annual statistical report on the Social Security Disability Insurance Program, 2011. Washington, DC: Author. [9] ...
... and it is far from established that brain activity responsible for human action can be affected by such events. Secondarily, ... In the philosophy of decision theory, a fundamental question is: From the standpoint of statistical outcomes, to what extent do ... Thomas Reid (January 2012). Essays on the Active Powers of the Human Mind; An Inquiry Into the Human Mind on the Principles of ... Thirteenth century philosopher Thomas Aquinas viewed humans as pre-programmed (by virtue of being human) to seek certain goals ...
In humans moclobemide is rapidly and almost completely absorbed and totally metabolised via the liver.[117] Peak plasma levels ... although statistical significance at the p=0.05 was not reached) as though moclobemide was equally effective as imipramine at ... conformational analysis and antidepressant activity of moclobemide new analogues". Pharm Acta Helv. 72 (2): 119-22. doi:10.1016 ... Platelet MAO is of the MAO-B and this is inhibited only to a small degree in humans; the inhibition is due to low levels of ...
"Introduction to Human Evolution". The Smithsonian Institution's Human Origins Program. January 27, 2010. Retrieved March 14, ... Each of these activities engaged the adults in different ways. The singing aided with memory, as these adults improved ... The DSM-IV TR (Diagnostic and Statistical Manual of Mental Disorders) lists bereavement as a mental health diagnosis when the ... J., Levitin, Daniel (2007). This is your brain on music : the science of a human obsession. ISBN 978-0452288522. . OCLC ...
Rosenberg, L.B., "Human swarming, a real-time method for parallel distributed intelligence," in Swarm/Human Blended ... It has become a challenge in theoretical physics to find minimal statistical models that capture these behaviours.[8][9][10] ... "Planes, Trains and Ant Hills: Computer scientists simulate activity of ants to reduce airline delays". Science Daily. April 1, ... "Swarms of Humans Power A.I. Platform". DNews.. *^ Rosenberg, L.; Baltaxe, D.; Pescetelli, N. (2016-10-01). "Crowds vs swarms, a ...
Human Development Indices Archived 19 December 2008 at the Wayback Machine, Table 3: Human and income poverty, p. 35. Retrieved ... Activity along the coast stimulated European interest in the interior, especially along the two great rivers, the Senegal and ... this statistic includes both citizens and people who are not citizens of the Ivory Coast (census 2017, p. 36) ... The first human presence in Ivory Coast has been difficult to determine because human remains have not been well preserved in ...
Statistical Bulletin. Office for national Statistics. 14 December 2011. p. 10. Archived (PDF) from the original on 4 May 2012. ... Industrial activities ceased in the dock with the closure of the power stations. The Port of Bristol Authority finally closed ... There is evidence of human habitation in the caves at Cheddar Gorge 11,000-10,000 years BC, during a partial thaw in the ice ... The human bone fragments it contained, from about 21 different individuals, are thought to be roughly between 10,200 and 10,400 ...
... because many economists were making theoretical and philosophical inroads in other areas of human activity. In his Essay on the ... Statistical methods such as regression analysis are common. Practitioners use such methods to estimate the size, economic ... Becker, Gary S. (1976). The Economic Approach to Human Behavior. University of Chicago Press. p. 5. ISBN 978-0-226-04112-4. .. ... In economics, labor is a measure of the work done by human beings. It is conventionally contrasted with such other factors of ...
His activities during the second half of his life include: *Consulting for U.S. companies such as Armour and Company, Dennison ... For Juran, human relations problems were the ones to isolate, and resistance to change was the root cause of quality issues. ... Working independently of W. Edwards Deming (who focused on the use of statistical process control), Juran-who focused on ... Juran is widely credited for adding the human dimension to quality management. He pushed for the education and training of ...
See Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (Alfred A. Knopf, 1985); Elof A. Carlson ... Genome assembly and validation; mathematical modeling and algorithm development; population genetics; applied statistical and ... auxiliary activities; 22% private philanthropy; 10% endowment; 3% corporate.[10] ... July 2004). "Large-scale copy number polymorphism in the human genome". Science. 305: 525-8. Bibcode:2004Sci...305..525S. doi: ...
Human footprints have been found from over 800,000 years ago in Norfolk[43] and traces of early humans have been found (at ... Bwrdd yr Iaith Gymraeg, A statistical overview of the Welsh language, by Hywel M Jones, page 115,, England. Published ... often associated with volcanic activity and the metamorphism of existing rock sequences. As a result of this eventful ... Gräslund, Bo (2005). "Traces of the early humans". Early humans and their world. London: Routledge. p. 62. ISBN 978-0-415-35344 ...
"U.S. Department of Health and Human Services, National Institutes of Health. 2010. Archived from the original on 2012-03-08.. ... Some activities in phase one included physical training, manual labor, skills training, drug therapy, and transition planning. ... is making efforts to reduce this statistic by teaching horticulture to its inmates. It is shown that the inmates that go ... Here inmates had daily schedules sixteen hours long where they participated in activities and showed discipline. ...
Related to human pose, shape, and activity, Black has contributed to the SURREAL dataset of human motions,[38] the JHMDB ... His early focus on statistical modeling of motion, particularly at motion discontinuities, led to two other prize papers. His ... Human motion and shape[edit]. Black is best known for his work on human motion and shape estimation. With Hedvig Sidenbladh and ... "Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia". J. Neural ...
Snyder and Large (2005)[15] performed a study examining rhythm perception in human subjects, finding that activity in the gamma ... Other work has shown that there are pronounced differences between righthanders and lefthanders (on a statistical basis) in how ... Two types of gamma activity were found by Snyder & Large: induced gamma activity, and evoked gamma activity. Evoked gamma ... However, induced gamma activity did not subside when a gap was present in the rhythm, indicating that induced gamma activity ...
All the population cooperates in these activities and plans through the social and mass organizations."[17] Privatization of ... Hirschfeld explains also that the Cuban Ministry of Health (MINSAP) sets statistical targets that are viewed as production ... In 1995 the Inter-American Commission on Human Rights of the Organization of American States informed the U.S. Government that ... such activities violate international law and has requested that the U.S. take immediate steps to exempt medicine from the ...
While approving of the increase in efficiency that humans reap by using resources such as expert systems in medicine or GPS in ... He states that, "all varieties of perception-indeed all varieties of thought or mental activity-are accomplished in the brain ... This stems from Gould's long-running public debate with E. O. Wilson and other evolutionary biologists over human sociobiology ... Although Dennett has expressed criticism of human sociobiology, calling it a form of "greedy reductionism", he is generally ...
"for his discovery of human blood groups"[۴۲] ۱۹۳۱ اتو واربورگ[۱] آلمان "for his discovery of the nature and mode of action of ... "for his fundamental research in مکانیک کوانتوم, especially for his statistical interpretation of the wavefunction"[۹۲] ... "for his analysis of trade patterns and location of economic activity"[۱۵۳] ... "President of the European Court for Human Rights"[۱۲۳] ۱۹۷۳ Henry A. Kissinger[۱] United States "For the 1973 Paris agreement ...
... with the goal of improving the parameterization of human activity algorithms in EPAs exposure modeling efforts. Despite the ... The results of a four-season longitudinal time-activity diary study in eight working adults are presented, ... and gender differences in the time spent in selected locations and activities are described, and D & A statistics are presented ... Understanding the longitudinal properties of the time spent in different locations and activities is important in ...
... however YAP activity remains unclear in dystrophic heart of DMD. Herein, we investigated YAP activity using disease-specific ... These results suggested that altered YAP activity due to impaired actin dynamics reduced proliferative ability in DMD-iPSC-CMs ... Hence, decreased YAP activity in dystrophic heart may contribute to DMD-cardiomyopathy pathogenesis. ... Therefore, immunofluorescent staining showed that actin stress fibers associated with YAP activity by mechanotransduction were ...
Statistical analysis. The significance of the in vitro results was determined using Students t-test (2-tailed). The ... NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Authors. *. Henry Q. Xiong,. * ... Constitutive NF-κB activity in human pancreatic cells differing in metastatic potential. (a) Nuclear protein was extracted from ... In summary, human pancreatic cancer cells have high levels of constitutive NF-κB activity, and many cytokines and growth ...
Here, human participants listened to questions and responded aloud with answers while we used high-density electrocorticography ... However, previous attempts to decode speech directly from the human brain typically consider listening or speaking tasks in ... Statistical testing: The statistical tests used in this work are all described in Section 2. For all tests, we considered p- ... Real-time decoding of question-and-answer speech dialogue using human cortical activity. *David A. Moses1. , ...
Statistical analysis. Data in text and tables are means ± SD. Analyses were performed using the SPSS software (version 10.0; ... The score of habitual physical activity was based on three factors: occupational physical activity, sport activity, and ... Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans. Gianluca Perseghin, Guido Lattuada, Francesco ... Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans. Gianluca Perseghin, Guido Lattuada, Francesco ...
We investigated the activity of STA-1474, a HSP90 inhibitor, in two canine lung cancer cell lines, BACA and CLAC. Results ... STA1474 demonstrated biological activity in both canine lung cancer cell lines and tumor-stromal fibroblasts. As significant ... This has major implications in availability of human treatments for dogs and in establishing translational models to test new ... Comparative genomic hybridization analysis of both cell lines revealed genetic relevance to human non-small cell lung cancer. ...
Conclusions: Plasma arylesterase activity was positively associated with plasma ChE specific activity. This observation is ... Results: Arylesterase activity had an independent, statistically significant positive association with ChE specific activity, ... Objective: To examine the association of several potential correlates (serum arylesterase/paraoxonase activity, serum albumin, ... Serum albumin was positively associated with ChE specific activity. ...
MMP enzyme activity was assessed using a fluorescent MMP-specific substrate. Statistical analysis was performed using analysis ... Bar graph illustrating the effect of pravastatin concentration (x) on MMP activity (y) by normal human chondrocytes after ... Total MMP activity assay. The total MMP activity of culture supernatants was evaluated using the MMP-substrate Mca-Arg-Pro-Lys- ... Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by ...
2A). This suggests that reduced PKCλ/ζ activity may contribute to insulin resistance in muscle in humans. PKCλ/ζ protein amount ... Statistical analysis.. Statistical analyses including correlation coefficients were performed using the Stat View program ( ... PKCλ/ζ activity and protein.. Basal activity of PKCλ/ζ was not different among the three groups (Fig. 2A). Insulin stimulated ... In the present study, we show that insulin stimulates PDK-1 activity in human skeletal muscle in vivo. Support for an insulin ...
Statistical Analysis.. The univariate analysis was done by the Kaplan-Meier method, and the test of significance was checked by ... Proliferative Activity of Intratumoral CD8+ T-Lymphocytes As a Prognostic Factor in Human Renal Cell Carcinoma. ... Proliferative Activity of Intratumoral CD8+ T-Lymphocytes As a Prognostic Factor in Human Renal Cell Carcinoma ... Proliferative Activity of Intratumoral CD8+ T-Lymphocytes As a Prognostic Factor in Human Renal Cell Carcinoma ...
Statistical analysis. All results were expressed as mean ± SEMs. Statistical analyses were performed using SPSS software (SPSS ... Human eosinophils induce Colo-205 cell apoptosis and necrosis. We first investigated the antitumoral activity of purified human ... Human Eosinophils Exert TNF-α and Granzyme A-Mediated Tumoricidal Activity toward Colon Carcinoma Cells. Fanny Legrand, ... The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are ...
Statistical analysis. Data were compared by the Students t test. Values of p , 0.05 were considered to be significant. ... HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. USA 95: 6308-6313 ... Binding and functional activity of CCL14a analogs on human chemokine receptors CCR1, CCR2, CCR3, CCR4, and CCR5 expressed in ... Significance of N-Terminal Proteolysis of CCL14a to Activity on the Chemokine Receptors CCR1 and CCR5 and the Human ...
Statistical Analysis. Values presented are means±SEM. Results were compared by ANOVA for repeated measurements followed by ... Procoagulant Activity. The surface procoagulant activity of human VSMCs was determined essentially as described.23 After ... B, Surface procoagulant activity of human VSMCs under control conditions (○ and on stimulation with thrombin (2 U/mL, 6 hours) ... Human α-thrombin (thrombin-specific clotting activity 3261 U/mg) was from Hemochrom Diagnostika. All other chemicals were from ...
Statistical Analysis. For each variable, values are expressed as mean±SD or SEM values. We calculated the intra-assay ... Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension. Josep Redón, Maria R. Oliva, Carmen Tormos, ... Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension. Josep Redón, Maria R. Oliva, Carmen Tormos, ... Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension. Josep Redón, Maria R. Oliva, Carmen Tormos, ...
... against human lung adenocarcinoma (A549) and human small airway epithelial cells (HSAEC). Combination of PG with DTX, PTX or ... against human lung adenocarcinoma (A549) and human small airway epithelial cells (HSAEC). Combination of PG with DTX, PTX or ... However, PGs cancer-specific activity has remained elusive until recently. Methods: PGs cancer-specific performance was ... However, PGs cancer-specific activity has remained elusive until recently. Methods: PGs cancer-specific performance was ...
Statistical Analysis. Statistical analysis was performed by ANOVA with Dunnetts correction for comparison of multiple groups ... especially in human cells, as reflected by neopterin accumulation.7 8 Human endothelial cells express GTPCH activity and ... Regulation of 6-Pyruvoyltetrahydropterin Synthase Activity and Messenger RNA Abundance in Human Vascular Endothelial Cells. ... Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal ...
GVS exposure did not cause a significant cytotoxic activity toward differentiated GBM cells and normal mesenchymal human stem ... GVS exposure did not cause a significant cytotoxic activity toward differentiated GBM cells and normal mesenchymal human stem ... isolated from nine human GBMs. We report that GVS induced a significant reduction of viability and self-renewal ability in all ... represents a pro-survival mechanism activated by GBM CSCs to counteract the efficacy of the anti-proliferative activity of GVS ...
Statistical Analyses. The data are presented as mean±SE for the number of experiments. Statistical significance (P,0.05) ... Enhancement of HO Activity in Endothelial Cells Transduced With Human HO-1. We examined HO activity in nontransduced ... Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells. ... Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells ...
Caspase 3 activity in HCT116 cells 24 h after treatment with 400 to 2,400 μM·min •NO. Increases in caspase 3 activity were ... Statistical analysis was performed by using a two-tailed Students t test, and P , 0.05 was considered to be statistically ... Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. Chun-Qi Li, Min Young Kim, Luiz C. Godoy, ... In contrast to a previous report that •NO donor drugs up-regulated GST A4 and GST P1 genes in human neuroblastoma cells (22), ...
Statistical analysis. For every individual HPV type, we estimated the incidence rate of first infection as well as of ... Human Papillomavirus Infection and Reinfection in Adult Women: the Role of Sexual Activity and Natural Immunity. Helen Trottier ... High-risk human papillomavirus is sexually transmitted: evidence from a followup study of virgins starting sexual activity ( ... Human Papillomavirus Infection and Reinfection in Adult Women: the Role of Sexual Activity and Natural Immunity ...
Statistical analysis. Statistical analysis was done using the Statistical Package for Social Sciences 13.0 (SPSS). Data are ... Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc. Ju Wang, Xue- ... Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc ... Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc ...
B, the statistical analysis graph of pulmonary metastatic colonies. The results are expressed as the mean ± SD, n = 6. **, P , ... Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 2006;66:4368-77. ... Pterostilbene exerts antitumor activity via the Notch1 signaling pathway in human lung adenocarcinoma cells. PLoS ONE 2013;8: ... In this study, we investigated the antitumor activity of silybin towards human lung adenocarcinoma cells in vitro and in vivo ...
Statistical Analyses.. The Students t test was used to measure statistical significance between two treatment groups. Multiple ... Ballas Z. K., Rasmussen W. L., Krieg A. M. Induction of NK activity in murine and human cells by CpG motif in ... In addition to the direct antitumor activity of G4 AS ODNs against human lung cancer xenografts, we have demonstrated that XIAP ... Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer ...
Statistical Analysis. Values are presented as the Mean±SD. Statistical comparisons were performed using one-way analysis of ... We examined the effects of overexpressed human chymase on survival and activity in lipopolysaccharide (LPS)-treated mice. Human ... Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice Kazi Rafiq1 , Yu-Yan Fan1, Shamshad J. ... Basal chymase activity in the heart and skin of 18-week-old wild-type C57BL/6 (WT) and transgenic (Tg) mice carrying the human ...
Statistical Analysis.. The Students t test (46) and the Mantel-Cox log-rank test (47) were used to evaluate the statistical ... GEO human colon cancer, OVCAR-3 human ovarian cancer, and ZR-75-1 human breast cancer cell lines were obtained from the ... A, antitumor activity of ZD-1839 treatment on established GEO human colon carcinoma xenografts. Mice were injected s.c. into ... Antitumor activity of ZD-1839 treatment in combination with cytotoxic drugs on established GEO human colon carcinoma xenografts ...
Climate, Soil and Human Activity Variables.. For each site, MAT and MAP were calculated using the WorldClim data layers (www. ... Statistical Analyses.. Details for statistical methods used in this study are available in SI Appendix, SI Materials and ... Human activity also had both direct and indirect effects on SOC storage, with the direct effects being negative in forests and ... 2 and Table 1). In addition, the negative effects of human activity on SOC storage were stronger in wet regions than in dry ...
In rectal tumors, there was an increased activity of uPA compared with the activity in colon tumors (P = 0.0266), however ... The enzyme activities or protein levels of MMP-2, MMP-9 and their endogenous inhibitors did not reach a statistically ... There is still debate whether the activity of MMP-2 and MMP-9 differs between tumors located in the colon and rectum. We ... uPA, uPAR and PAI-1 were examined using enzyme-linked immunosorbent assay (ELISA). The activity of uPA was assessed by casein- ...
... stimulated human chondrocytes cell line (NHAC-kn) using zymography method. The Payena dasyphylla methanolic bark extract was ... The aim of this study was to screen selected Malaysian plants on their anti-hyaluronidase activity as well as to evaluate the ... In addition, the Payena dasyphylla EA fraction showed strong antioxidant activity with IC50 value of 11.64 ± 1.69 μg/mL. These ... We also reported that the inhibitory effect of Payena dasyphylla on hyaluronidase activity and expression might be due to its ...
Statistical Analyses.. Multiple linear regression and nonparametric Spearman rank order correlation analyses were performed ... 1996) Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch Biochem Biophys 331: ... 1999) Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide ... 2000) Scaling drug biotransformation data from cDNA-expressed CYP to human liver: A comparison of relative activity factors and ...
... for their cytotoxic activity against three human cancerous cell lines MCF7, HeLa and HepG2. The extracts of Maesa macrophylla ... human hepatocarcinoma cell line (HepG2) and human cervix adenocarcinoma cell line (HeLa). The cytotoxicity was evaluated by ... The ethanolic leaf extracts of 30 medicinal plants were tested for their cytotoxicity against human breast adenocarcinoma cell ... the in vitro anticancer properties of traditionally used medicinal plants from the Darjeeling hills against different human ...
  • In this study, we aimed to evaluate the effect of pravastatin on MMP expression and MMP activity in a simple in vitro model of articular cartilage catabolism. (
  • In this study, we investigated the antitumor activity of silybin towards human lung adenocarcinoma cells in vitro and in vivo and explored the role of the SIRT1 signaling pathway in this process. (
  • SIRT1 siRNA ( in vitro ) or cambinol (a known SIRT1 inhibitor used for in vivo studies) further enhanced the antitumor activity of silybin. (
  • In this study, we investigated the effect of XIAP down-regulation by antisense oligonucleotides (AS ODNs) on human non-small cell lung cancer (NIH-H460) growth in vitro and in vivo . (
  • If the goal of in vitro studies on cDNA-expressed CYPs is to extrapolate the results to human liver microsomal drug metabolism, the experimental conditions with respect to such accessory non-CYP factors should be parallel in the two systems ( Remmel and Burchell, 1993 ). (
  • These considerations introduce additional complexity in bridging the gap between expression systems and human liver microsomes, thereby complicating in vitro-in vivo scaling of metabolic rates and relative contributions of the various isoforms. (
  • In this study, we explored the in vitro anticancer properties of traditionally used medicinal plants from the Darjeeling hills against different human cancer cell lines. (
  • Immobilized recombinant perlecan domain I (PlnDI) binds and modulates the activity of heparin-binding growth factors, in vitro . (
  • In this study, we assessed the ability of soluble forms to modulate vascular endothelial growth factor-165 (VEGF 165 ) enhanced capillary tube-like formation, and VEGF receptor-2 phosphorylation of human bone marrow endothelial cells, in vitro . (
  • These results demonstrated that the promotive effect of CD73 on cervical cancer cells proliferation and migration in vitro was independent from its enzymatic activity (i.e. production of adenosine). (
  • Plant-based compounds such as terpenoids, flavonoids, phenolic compounds, alkaloids, xanthones, coumarins, anthocyanins, carotenoids, etc, have been reported to exhibit potent anticancer activity against a range of cancer cells in various in vitro and in vivo experimental models. (
  • Its effect on formation and activity of human osteoclasts in vitro was determined in cocultures of human osteoblasts and peripheral blood mononuclear cells. (
  • To evaluate the effect of the anti-VEGF-A monoclonal antibody bevacizumab on primary human Tenon's capsule fibroblasts (HTFs) in an in vitro model of wound healing. (
  • Clonal murine T cells can be used to measure, characterize, and quantify the in vitro immunosuppressive activity of human MSCs, representing a promising approach to improve bioassays for immunosuppression. (
  • In vitro infection set-ups using human skeletal muscle and colon cell lines were designed to assess the antiviral effect of the probiotic bacteria during entry and post-entry steps of the infection cycle. (
  • Should the antiviral activity of L. reuteri Protectis observed in vitro be translated in vivo, such probiotics-based therapeutic approach may have the potential to address the urgent need for a safe and effective means to protect against HFMD and limit its transmission among children. (
  • In vitro analyses of their antimicrobial activities indicated that they possessed different antimicrobial spectra. (
  • Using an in vitro cell surface TF assay and TF ELISA, the activity and production of TF in cultured alveolar epithelial (A549) cells following exposure to cytomix (tumour necrosis factor α, interleukin 1β and interferon γ) was measured. (
  • Methods and Results - Thrombin not only stimulated TF mRNA expression, but also TF-dependent surface procoagulant activity in cultured human VSMCs. (
  • Methods and Results -Pteridine production, mRNA expression of GTP cyclohydrolase (GTPCH) and 6-pyruvoyltetrahydropterin synthase (PTPS) (both key enzymes of BH4 biosynthesis), and PTPS activity were studied in human umbilical vein endothelial cells (HUVECs) exposed to inflammatory cytokines. (
  • METHODS AND RESULTS: Human aortic endothelial cells (HAECs) were pretreated with various concentrations (primarily 50 μg/mL) of Aronia Melanocarpa fruit extract prior to treatment with TNFα (10 ng/mL) for various periods of time. (
  • Examples include: networks, stochasticity and statistical methods. (
  • Human Dynamics as a branch of statistical physics: Its main goal is to understand human behavior using methods originally developed in statistical physics. (
  • conversely, GVS exposure did not cause a significant cytotoxic activity toward differentiated GBM cells and normal mesenchymal human stem cells. (
  • This is perhaps the first report of screening of traditional medicinal plants from Darjeeling district in West Bengal, India, for their cytotoxic activity against three human cancerous cell lines MCF7, HeLa and HepG 2 . (
  • Therefore, the present study aims to investigate the cytotoxic activity of Androctonus australis hector (Aah) scorpion venom and its toxic fractions (FtoxG-50 and F3) on NCI-H358 human lung cancer cells. (
  • In addition, silybin exhibited strong antitumor activity illustrated by reductions in tumor cell adhesion, migratory capability, and glutathione levels and by increased apoptotic indices and reactive oxygen species levels. (
  • This antitumor activity was associated with an 85% down-regulation of XIAP protein in the tumors. (
  • In recent years there has been a growing appetite for access to new data sources that might prove useful in quantifying and understanding human behavior both at the individual and collective scales. (
  • To elucidate the effects of gravity on human physiology and behavior, we examined changes in wrist and trunk activities and heart rate during parabolic flight and the activity of wrist and trunk in water immersion experiments. (
  • Perception and behavior can be guided by predictions, which are often based on learned statistical regularities. (
  • Analyzes network activity by continuously calculating more than 70 device behavior analytics. (
  • 1 Intracellular BH4 availability modulates NO-mediated cGMP production in human endothelial cells, whereas BH4 synthesis is regulated by inflammatory and anti-inflammatory cytokines. (
  • 2 3 Interestingly, inflammatory cytokines enhance BH4 synthesis and constitutive NO synthase (cNOS) specific activity, with a concomitant decrease of cNOS enzyme in human vascular endothelial cells. (
  • 7 8 Human endothelial cells express GTPCH activity and synthesize small amounts of BH4 constitutively. (
  • Recently, GTPCH mRNA induction by cytokines has been reported in human endothelial cells, 11 but nothing is known about regulation of PTPS in those cells. (
  • Because vascular endothelial cells are the main producers of BH4 in physiological and pathological conditions, 3 4 10 12 we investigated the expression of GTPCH and PTPS, the key enzymes of BH4 biosynthesis, at the molecular level in human umbilical vein endothelial cells (HUVECs) under normal and inflammatory conditions. (
  • In the present study, we determined the effect of interventions that suppress HO activity or induce HO-1 gene expression on Ang II-mediated increase in 6-keto-PGF 1α and PGE 2 in cultures of human femoral artery endothelial cells. (
  • 6 According to a recent study, prostaglandin synthesis in rabbit coronary and human endothelial cells decreases in response to interventions that upregulate the expression of heme oxygenase (HO)-1. (
  • We tested this hypothesis by examining the effect of interventions that suppress HO activity, or induce HO-1 gene expression, on Ang II-induced prostaglandin synthesis in cultures of human femoral endothelial cells. (
  • Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. (
  • Bacteria cause serious infection in human as well as other animals. (
  • We demonstrate use of the assay to quantify the kinetics of paracrine antiviral signaling from human prostate cancer (PC3) cells in response to viral infection. (
  • We have found that intranasal immunization with recombinant chlamydial protease-like activity factor (CPAF) induces CD4 + T-cell- and gamma interferon (IFN-γ)-dependent protective immunity against murine genital chlamydial infection, thus making CPAF a viable vaccine candidate for further characterization. (
  • These data differentiate gB-G eVLPs from gB antigens used in the past and support their use in a CMV vaccine candidate with improved neutralizing activity against epithelial cell infection. (
  • A global spatial statistic was used to detect area-wide trends of clustering for human infection at the household level. (
  • Local spatial statistics were then applied to detect specific household clusters of infection, and, as a focal spatial statistic, to evaluate clustering of infection around a putative transmission site. (
  • Spatial patterns of human water contact and Schistosoma mansoni transmission and infection in four rural areas in Machakos District, Kenya. (
  • Genital human papillomavirus (HPV) infection is generally considered to be sexually transmitted. (
  • Inhibition of cholinesterase (ChE) activity in blood has been used as a biomarker for exposure to organophosphates (OPs) and carbamates since 1950 [ 1 ]. (
  • Because of the large inter-individual variability in the mass concentration of ChE in plasma, a single measurement of ChE activity alone cannot accurately detect inhibition in an individual. (
  • ZD-1839 treatment of nude mice bearing established human GEO colon cancer xenografts revealed a reversible dose-dependent inhibition of tumor growth because GEO tumors resumed the growth rate of controls at the end of the treatment. (
  • We have developed an antiviral assay based on replication inhibition of an engineered fluorescent vesicular stomatitis virus reporter strain on A549 human lung epithelial cells. (
  • These paracrine signaling molecules can work synergistically, so measurement of any one antiviral molecule does not reflect the total antiviral activity of the system. (
  • A dsRed2-strain of vesicular stomatitis virus that is sensitive to type I, II, and III interferons was used to develop a convenient and sensitive assay for interferon antiviral activity. (
  • In this work, the antiviral activity of two commercially available probiotics, namely Lactobacillus reuteri Protectis ( L. reuteri Protectis) and Lactobacillus casei Shirota ( L. casei Shirota), was assayed against Coxsackieviruses and Enterovirus 71 (EV71), the main agents responsible for HFMD. (
  • Our findings indicate that L. reuteri Protectis displays a significant dose-dependent antiviral activity against Coxsackievirus type A (CA) strain 6 (CA6), CA16 and EV71, but not against Coxsackievirus type B strain 2. (
  • STA1474 demonstrated biological activity in both canine lung cancer cell lines and tumor-stromal fibroblasts. (
  • We next analyzed the proliferative activity of CD8 + T cells that infiltrated in tumor cell nests, which could also reflect antitumor immunity. (
  • Our data in human renal cell carcinoma suggest that infiltration of tumor tissue by T cells itself does not denote the efficacy of antitumor immunity because of its dependence on the biological malignancy of tumor cells, but infiltration of tumor tissue by CD8 + T cells bearing more pronounced proliferative activity could reflect effective antitumor immunity. (
  • The biological malignancy of human cancer is determined by the net effects of biological malignancy of tumor cells and host factors. (
  • We have in this study investigated the direct interactions of human eosinophils with Colo-205, a colorectal carcinoma cell line, and show that eosinophils induce apoptosis and directly kill tumor cells. (
  • Our data present the first demonstration, to our knowledge, that granzyme A is a cytotoxic mediator of the eosinophil protein arsenal, exerting eosinophil tumoricidal activity toward Colo-205, and provide mechanistic evidence for innate responses of eosinophil against tumor cells. (
  • These findings suggest that uPA may be expressed differentially in colon and rectal cancers, however, the activities or protein levels of MMP-2, MMP-9, TIMP-1, TIMP-2, PAI-1 and uPAR are not affected by tumor location in the colon or the rectum. (
  • Therefore, drugs like AZD0530, designed to inhibit Src activity, could selectively interfere with both tumor and osteoclast activity. (
  • A fully human anti-PD-L1 mAb would potentially be able to block PD-1/PD-L1 interactions and also mediate the ADCC lysis of tumor cells. (
  • Aeae Cec1-5 efficiently inhibited the expression of inducible nitric oxide synthase (iNOS), nitrite, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages and human peripheral blood mononuclear cells (PBMCs) with low toxicity to mammalian cells. (
  • PG's cancer-specific performance was compared to Docetaxel (DTX), Paclitaxel (PTX), and Doxorubicin (DOX) against human lung adenocarcinoma (A549) and human small airway epithelial cells (HSAEC). (
  • TF activity, mRNA and protein levels increased in A549 cells after stimulation with cytomix. (
  • Increased TF activity was also seen in A549 cells following incubation with pulmonary oedema fluid from patients with ALI/ARDS. (
  • The enzyme activities or protein levels of MMP-2, MMP-9 and their endogenous inhibitors did not reach a statistically significant difference between colon and rectal cancer compared with their normal mucosa. (
  • In this study, RAFs determined for CYPs 1A2, 2B6, 2C19, 2D6, and 3A4 in 12 human livers using lymphoblast-expressed enzymes were compared to immunoquantified protein levels. (
  • Although factors like ionic strength are easily controlled to ensure similar conditions in both systems, accessory protein concentrations similar to human liver microsomes may not be achievable and thus may well differ between microsomes containing cDNA-expressed CYPs and human liver microsomes. (
  • One such protein critical for osteoclast activity is c-Src kinase, which is highly expressed in osteoclasts ( 9 , 10 ). (
  • Cell adhesion assays and analyses of gene and protein expression were used to examine the effect of SAS on ARPE-19 cells or primary human RPE cells that were grown alone or in an RPE-EC co-culture. (
  • Using BEAS-2B (a human bronchial epithelial cell-line), we demonstrated that RV replication increased the expression of TLR3 mRNA and TLR3 protein on the cell surface. (
  • We provide evidence that MMP-12 mRNA and protein are expressed by in-situ human airway smooth muscle cells obtained from bronchial biopsies of normal volunteers, and of patients with asthma, COPD and chronic cough. (
  • IL-1beta-induced MMP-12 activity and gene expression was down-regulated by the corticosteroid dexamethasone but up-regulated by the inflammatory cytokine tumour necrosis factor (TNF)-alpha through enhancing activator protein-1 activation by IL-1beta. (
  • Human C5a is a plasma protein with potent chemoattractant and pro-inflammatory properties, and its overexpression correlates with severity of inflammatory diseases. (
  • These results suggest an important role for CPAF in antichlamydial immunity and the relevance of additional characterization of this protein as a potential vaccine candidate for humans. (
  • gB-G-expressing eVLPs induced potent neutralizing antibodies in mice with a much greater propensity toward epithelial cell-neutralizing activity than that induced with soluble recombinant gB protein. (
  • In humans and other mammalian species, the structures are very small, measuring approximately 1 × 0.1 mm. 2 , 4 SCN rhythms seem to be driven by the complex interaction of a handful of transcriptional regulators and kinases resulting in 24-hour cycles of protein expression. (
  • Growth differentiation factor-15 protein levels were significantly increased in human TM cells in response to TGF-β2, dexamethasone, endothelin-1, lysophosphatidic acid, TNF-α, IL-1β treatment, and by cyclic mechanical stretch. (
  • Recent studies identified an autism-linked mutation within E6AP at T485, which was identified as a protein kinase A phosphoacceptor site and which could directly regulate E6AP ubiquitin ligase activity. (
  • The E6 oncoprotein exerts strong antiapoptotic and growth-promoting activities, which are also achieved through a plethora of protein-protein interactions. (
  • The aim of this study is to assess the ability of pravastatin to modify matrix metalloproteinase (MMP) messenger RNA (mRNA) expression and enzyme activity in a culture of normal human chondrocytes stimulated by interleukin-1β. (
  • MMP enzyme activity was assessed using a fluorescent MMP-specific substrate. (
  • Treatment with pravastatin of stimulated human chondrocytes leads to significant down-regulation of selected MMP genes and a non-significant reduction in MMP enzyme activity. (
  • Our data suggested that CD73 might promote proliferation and migration via potentiating EGFR/Akt and VEGF/Akt pathway, which was independent of CD73 enzyme activity. (
  • An approach to potentially overcome this limitation is to measure ChE mass, which is the concentration of ChE enzyme measured typically by enzyme-linked immuno-absorbent assay (ELISA), in blood along with ChE activity and calculate "specific ChE activity" (activity divided by mass). (
  • Accordingly, we assessed NTCP mRNA expression from human livers using a sensitive RNase protection assay. (
  • Zymography assay showed that SAS reduced the level of MMP-2 activity in RPE cells. (
  • The cytotoxic and antiproliferative activities were estimated using MTT assay, lactate dehydrogenase release and clonogenic assays. (
  • Apoptosis was evaluated by Hoechst 33258 staining, DNA fragmentation assay and caspase-3 activity. (
  • Our assay provides a quantitative functional readout of human type I, II, and III interferon activities, and it provides better sensitivity, intra-, and inter-assay reproducibility than the traditional crystal violet based assay. (
  • augmented Akt activity was confirmed using a Glycogen Synthase Kinase phosphorylation assay. (
  • The HTF-derived iPS (TiPS) cells were analyzed with phase contrast microscopy, real-time PCR, immunofluorescence, FACS analysis, alkaline phosphatase activity analysis, and a teratoma formation assay. (
  • Using magnetoencephalography, we recorded the cortical activity of human participants while they observed actions performed by another person. (
  • Insulin-stimulated insulin receptor substrate (IRS)-1 tyrosine phosphorylation and PI3K activity are impaired 40-50% in diabetic subjects compared with lean or obese subjects. (
  • To elucidate the functional role of the N terminus, a panel of N-terminally truncated CCL14a analogs were tested on the receptors CCR1 to CCR5 and on the human cytomegalovirus (HCMV)-encoded chemokine receptor US28. (
  • Interestingly, the human CMV (HCMV) 3 -encoded chemokine receptor US28 may serve as a coreceptor for HIV-type 1 entry into cells as well ( 9 ). (
  • US28 is structurally similar to the human chemokine receptor CCR1 ( 12 , 13 ) and binds a broad spectrum of chemokines ( 10 , 11 , 14 , 15 ). (
  • In rectal tumors, there was an increased activity of uPA compared with the activity in colon tumors (P = 0.0266), however urokinase-type plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) showed no significant difference between colon and rectal cancer tissues. (
  • Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. (
  • We identify nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α as regulators of human telomere transcription. (
  • Moreover, eosinophils expressed granzyme A, which was released upon interaction with Colo-205, whereas cytotoxicity was partially inhibited by FUT-175, an inhibitor of trypsin-like enzymatic activity. (
  • The CD73 specific antagonist -APCP was used to inhibit CD73 enzymatic activity. (
  • Our data showed that CD73 overexpression significantly promoted cervical cancer cells proliferation and migration, and this promotive effect was not reverted by blocking CD73 enzymatic activity, both in Hela and SiHa cells. (
  • Moreover, this promotive effect of CD73 should be via an enzymatic activity independent mechanism. (
  • GD also inhibited tyrosinase enzymatic activity. (
  • These results demonstrate that HPV E6 overrides the normal phosphoregulation of E6AP, both in terms of its enzymatic activity and its subcellular distribution. (
  • IMPORTANCE Recent reports demonstrate the importance of phosphoregulation of E6AP for its normal enzymatic activity. (
  • It has been an open question how similar human and canine lung cancers are. (
  • FGFR overexpression is involved in the tumorigenesis and progression ( 19-21 ) of multiple types of human cancers, such as breast and prostate cancers. (
  • Although silybin, a natural flavonolignan, has been shown to exhibit potent antitumor activities against various types of cancers, including lung cancer, the molecular mechanisms behind these activities remain unclear. (
  • Thus, identification of novel agents that are relatively safe but can suppress growth of both ER-positive and ER-negative human breast cancers is highly desirable. (
  • Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, with cervical cancer being the most prevalent ( 1 ). (
  • There are multiple HPV types capable of infecting either mucosal or cutaneous tissues ( 2 ), but only a small subset are associated with the development of human cancers. (
  • The active plant extract ( Payena dasyphylla ) was then studied for its hyaluronidase inhibitory activity in the interleukin-1β (IL-1β) stimulated human chondrocytes cell line (NHAC-kn) using zymography method. (
  • The results of a four-season longitudinal time-activity diary study in eight working adults are presented, with the goal of improving the parameterization of human activity algorithms in EPA's exposure modeling efforts. (
  • These results suggested that altered YAP activity due to impaired actin dynamics reduced proliferative ability in DMD-iPSC-CMs. (
  • Our results suggest that the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps. (
  • Accordingly, these results indicate that large interindividual variability exists in NTCP mRNA level and that a number of drugs currently in clinical use have the potential to interact with and alter NTCP activity, thereby affecting hepatic bile acid uptake. (
  • These results demonstrated that bevacizumab inhibited a number of fibrosis activities in culture. (
  • These results support the potential use of curcumin as a novel candidate in treatment of human lung cancer. (
  • The results from the water immersion experiments demonstrated that in the underwater condition, both the wrist and trunk activities were significantly decreased but the latter decreased to a much lower level. (
  • Thus, at present it remains unclear whether statistical learning automatically results in altered neural responses to expected compared to unexpected visual stimuli, or whether this process hinges on the stimuli being attended. (
  • Together, these results demonstrate the importance of human HLA-DR4 molecules in the recognition and presentation of CPAF epitopes, leading to the generation of protective antichlamydial immunity and making these mice a valuable model for mapping HLA-DR4-restricted chlamydial epitopes. (
  • The finding that activity in the motor system is modulated dynamically when observing actions can explain why studies of action observation using functional magnetic resonance imaging have reported conflicting results, and is consistent with the hypothesis that we motorically simulate observed actions. (
  • Results from a latent cluster analysis of National Collegiate Athletic Association athletics department employees ( N = 4,324) revealed five distinct employee archetypes utilizing inputs related to human capital development and work experiences (e.g., work-family interface, work engagement, age). (
  • Comparing Performance Results using NEWFM and Statistical Method. (
  • We propose PlnDI liberated during basement membrane or extracellular matrix turnover may have similar activities, in vivo . (
  • The effect on osteoclasts formed in vivo was assessed in mouse fetal calvarial explants and in isolated rabbit osteoclasts, where it dose-dependently inhibited osteoclast activity. (
  • These activities may underpin the antifibrosis effect proposed in vivo. (
  • Both interleukin (IL)-13 and IL-4, but not IL-10, are potent inhibitors of iNOS expression and activity induced by an optimal combination of cytokines, namely IL-1α, tumour necrosis factor α and interferon γ. (
  • Additionally, it has been observed that the extract of Aronia melanocarpa (A. Melanocarpa) fruits, rich in polyphenols, exhibits potent anti-oxidant properties and displays cardioprotective activity. (
  • We have hypothesized that a turn conformation is important for activity of the C terminus of C5a and herein report small cyclic peptides that are stable turn mimics with potent antagonism at C5aR on human PMNLs. (
  • Two of the five gB-G eVLP-induced monoclonal antibodies we examined in detail had neutralizing activities, one of which possessed particularly potent epithelial cell-neutralizing activity. (
  • But the city's new effort seems to ignore evidence, including recent research from members of our policing study team at the Human Rights Data Analysis Group , that predictive policing tools reinforce, rather than reimagine, existing police practices. (
  • At its core, any predictive model or algorithm is a combination of data and a statistical process that seeks to identify patterns in the numbers. (
  • She is responsible for data analytic activities, economic modeling, predictive modeling, and statistical analysis. (
  • Research activities to assemble data, analytical and predictive tools and knowledge into a useable format for analysts and decision makers. (
  • Zhang Z, Feng Y, Li Z, Cao X. Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway. (
  • In high concentrations, CCL14a(12-74) did reveal antagonistic activity on intracellular Ca 2+ concentration mobilization in CCR1- and CCR5-transfected cells, which suggests that truncation of Tyr 11 might be of significance for an efficient inactivation of CCL14a. (
  • Analysis of variance was used to determine statistical significance. (
  • Statistical significance was determined with one-way repeated-measures ANOVA with Fisher's least significance difference (LSD) post hoc test. (
  • Statistical significance was determined by Student- t test. (
  • Human papillomavirus (HPV) infections are among the most common sexually transmitted infections ( 1 , 2 ). (
  • The human papillomavirus (HPV) E6 oncoproteins recruit the cellular ubiquitin ligase E6AP/UBE3A to target cellular substrates for proteasome-mediated degradation, and one consequence of this activity is the E6 stimulation of E6AP autoubiquitination and degradation. (
  • Among the five analogues, Aeae Cec5 had the strongest anti-inflammatory activity, and generated an additive effect with other Aeae Cec peptides. (
  • Thrombin induces TF mRNA in vascular smooth muscle cells (VSMCs), thereby contributing to the prolonged procoagulant activity and enhanced thrombogenicity at sites of vascular injury. (
  • Prolonged procoagulant activity induced by vascular injury has been associated with restenosis after balloon dilatation or the development of atherosclerosis. (
  • 10 Assessment of antioxidant activities and lipid peroxidation byproducts in hypertensive subjects indicates an excessive amount of ROS and a reduction of antioxidant mechanism activity in both blood as well as in several other cellular systems, 11 including not only vascular wall cells 12 but also those found in circulating blood. (
  • 4 In vascular smooth muscle cells (SMCs), inducible NO synthase (iNOS) is upregulated by inflammatory cytokines, and therefore BH4 becomes limiting for maximal iNOS activity. (
  • Acute human exposures to CAPs of coarse and fine size fractions result in cardiovascular responses including increased BP, vascular narrowing of the brachial artery diameter (BAD), vascular/autonomic dysfunction (impaired flow-mediated dilatation [FMD]), inflammation (respiratory and systemic), and oxidative stress compared to filtered air (control) exposures. (
  • Conclusions These data provide proof of principle for human LEPC based vascular repair therapy, and demonstrate a mechanism by which to rescue marked progenitor dysfunction in a group at high risk of cardiovascular events, whom are likely to benefit from cardiovascular repair therapies. (
  • However, the anticancer activity of CA on human colorectal cancer cells and the underlying mechanisms remain to be elucidated. (
  • Lysophosphatidic acid (LPA), a known lipid mediator on induction of actin polymerization, significantly increased YAP activity and actin dynamics in DMD-iPSC-CMs using live cell imaging. (
  • In both, whole blood and peripheral mononuclear cells oxidized/reduced glutathione ratio and malondialdehyde was significantly higher, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly lower in hypertensive patients when compared with normal subjects. (
  • LPS-induced increases in chymase activity in the heart and skin were significantly greater in Tg than WT mice. (
  • GD significantly inhibited melanin synthesis in the melan-a cells and a reconstructed human skin model. (
  • Treatment with SAL significantly reduces CPS production in HV-KP, thereby contributing to leukocyte phagocytosis and bactericidal activity against this pathogen. (
  • We found that α-secretase activity is significantly elevated in the presence of FAs with short chain length and in the presence of polyunsaturated FAs, whereas variations in the phospholipid headgroups, as well as the double-bond position, have little or no effect on α-secretase activity. (
  • Furthermore, E6 interaction with E6AP also significantly alters how E6AP is subject to autodegradation and suggests that this is not a simple stimulation of an already-existing activity but rather a redirection of E6AP activity toward itself. (
  • In addition, the ability of various bile acids and drugs to inhibit NTCP activity was determined using a recombinant vaccinia expression system. (
  • however YAP activity remains unclear in dystrophic heart of DMD. (
  • Conclusions -The data suggest that the epithelium is the major source of iNOS activity in ulcerative colitis and that IL-13 and IL-4 may act as intrinsic regulators of NO generation in intestinal inflammation. (
  • Glycyrrhiza glabra is an important medicinal plant with tremendous pharmacological activities which include neuroprotection, antimicrobial and anticancer activities. (
  • These venoms also contain several pharmacologically active components that could elicit great interest as a source of proteins and peptides for the design and the development of new drugs with antimicrobial, anti-parasitic, analgesic, immunosuppressing and anticancer activities [ 1 , 3 , 5 ]. (
  • The effect of oral aspirin intake on the leukocyte bactericidal activity was evaluated. (
  • In the present study, we tried to examine this hypothesis by investigating the effect of SAL on bacterial survival, hypermucoviscosity, CPS production, leukocyte phagocytosis, and bactericidal activity against HV-KP. (
  • Conclusion - These findings indicate that the NADPH oxidase is essentially involved in the redox-sensitive induction of TF mRNA expression and surface procoagulant activity by thrombin. (
  • 0.001) in patients with ALI/ARDS, and TF procoagulant activity in oedema fluid was much higher than in plasma of these patients. (
  • Previous studies have shown that there is TF-dependent procoagulant activity in bronchoalveolar lavage (BAL) fluid in patients with ARDS, 2, 4 but comparison with a comparable control group (intubated patients with hydrostatic oedema) was not performed. (
  • To date, 10 human TLRs have been described, with specific pathogen-associated molecular patterns identified for 9 of them ( 5 , 17 , 19 ). (
  • The opportunistic human fungal pathogen Candida albicans can cause a variety of diseases, ranging from superficial mucosal infections to life-threatening systemic infections. (
  • We show here that the human opportunistic fungal pathogen Candida albicans influences l -arginine availability for nitric oxide production by induction of the substrate-competing host enzyme arginase-1. (
  • Chlamydia trachomatis is a human pathogen that exhibits a tropism for conjunctival and urogenital columnar epithelial cells ( 26 ). (
  • Antibacterial activity of Rhynocoris marginatus (Fab. (
  • We detected the antibacterial activity of R. marginatus and C. brevipennis venoms against seven Gram-negative and four Gram-positive bacteria by using the disc diffusion method. (
  • Rhynocoris marginatus venom exhibited antibacterial activity against four Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa , Proteus vulgaris , Salmonella typhimurium ) and one Gram-positive ( Streptococcus pyogenes ). (
  • Antibacterial activity has been widely reported in venoms from different snakes including Pseudechis australis (28). (
  • As far as we are aware, antibacterial activity in reduviid venom has not been reported. (
  • For example, we have recently demonstrated that stimulation with a "cocktail" of proinflammatory cytokines induces iNOS mRNA expression and nitrite generation in the human colonic carcinoma cell line HT-29. (
  • We further determined that purified chitin (a fungal cell wall polysaccharide) and increased chitin exposure at the fungal cell wall surface induces this host arginase activity. (
  • NO-induced apoptosis of human colon cancer HCT116 cells. (
  • NO activates Nrf2-Keap1 signaling and affects induction of apoptosis in HCT116 human colon carcinoma cells. (
  • In the present study, the effects of curcumin‑induced multiple PCDs on human non‑small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co‑culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002. (
  • In this study, we investigated the effects of CA on cell viability and apoptosis in HCT116 human colon cancer cells. (
  • Hence, it is clear that the dysregulation of apoptosis plays an important role in the pathogenesis of several of human diseases, including cancer ( 4 ). (
  • Laser capture microdissection was used to collect smooth muscle cells from human bronchial biopsy sections. (
  • Bronchial smooth muscle cells may be an important source of elastolytic activity, thereby participating in remodeling in airway diseases such as COPD and chronic asthma. (
  • Sections from human bronchial samples were prepared (A). Cell cultures were incubated on 8-well chamber slides for 72 hours in the absence (B) or presence (C) of 10 ng/ml IL-1β. (
  • The aim of this study was to screen selected Malaysian plants on their anti-hyaluronidase activity as well as to evaluate the active plant and its derived fractions on its potential anti-arthritic and antioxidant activities. (
  • Although high incidence and prevalence are found in both females and males soon after the onset of sexual activity, the vast majority of genital HPV infections are asymptomatic and clear within 1 to 2 years ( 4 , 5 ). (
  • The second hypothesis hinges on the notion that infections do clear following an initial immune response, which does not completely protect against future infections by the same HPV type, following new exposure via sexual activity later in life. (
  • Most research on venoms has focused on the identification, isolation and purification of proteins and peptides with pharmacological activity like neurotoxins (8, 20, 22) and antimicrobial peptides, whose presence in the venom has been suggested to be a defense mechanism against infections arisen during ingestion of the prey (29, 30). (
  • Human cytomegalovirus (HCMV) establishes persistent infections that are typically asymptomatic except among immunocompromised individuals and in utero after congenital transmission. (
  • COX-1 and COX-2 are heme proteins, 6 and it is well documented that the heme prosthetic group of both COX isoforms is essential for the expression of catalytic activity. (
  • Use of metabolic rates from cDNA-expressed CYPs containing nonphysiologic concentrations of electron-transfer proteins (relative to human liver microsomes) in conjunction with hepatic CYP contents may lead to incorrect predictions of liver microsomal rates and relative contributions of individual isoforms. (
  • Knowledge about proteins specifically involved in the activity of osteoclasts is a prerequisite for developing therapies targeting the osteoclast in pathologies such as cancer-related bone lysis and may also be beneficial in rheumatoid arthritis, osteoporosis, and periodontitis, where excessive and unwanted resorption occurs. (
  • Stimulation of human TM cells with rGDF-15 caused a significant increase in the formation of actin stress fibers and focal adhesions, myosin light chain phosphorylation, SMAD signaling, gene expression, and the levels of αSMA and ECM proteins. (
  • Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. (
  • Growth differentiation factor-15, a common constituent of ECM derived from the human TM cells, was confirmed to be distributed throughout the conventional aqueous humor outflow pathway of the human eye. (
  • Here we demonstrate real-time decoding of perceived and produced speech from high-density ECoG activity in humans during a task that mimics natural question-and-answer dialogue (see Supplementary Movie 1 ). (
  • We demonstrate that, in electrocorticographic (ECoG) recordings from the surface of the human brain, strong error-related neural responses (ERNRs) for both types of errors can be observed. (
  • We demonstrate that blocking of host arginase-1 activity restored nitric oxide production and increased the killing potential of macrophages. (
  • We investigated the activity of STA-1474, a HSP90 inhibitor, in two canine lung cancer cell lines, BACA and CLAC. (
  • Comparative genomic hybridization analysis of both cell lines revealed genetic relevance to human non-small cell lung cancer. (
  • These studies support the contention that XIAP is a viable target for cancer therapy in human non-small cell lung cancer. (
  • 18 , 19 NF-κB activity can also be elevated by several stress factors in human pancreatic cancer cells, such as hypoxia, acidosis, nitric oxide and proinflammatory cytokines. (
  • Here, human participants listened to questions and responded aloud with answers while we used high-density electrocorticography (ECoG) recordings to detect when they heard or said an utterance and to then decode the utterance's identity. (
  • It also inhibited the expression of the two prominent molecular targets of cancer, c-Myc and the human telomerase reverse transcriptase (hTERT). (
  • The molecular targets and mechanisms by which EGCG exerts chemopreventive activities are only in part elucidated [ 7 ]. (
  • The molecular cascades governing the development and maturation of the CNS are highly conserved in adult organisms and contribute to complex experiential phenomena such as activity-dependent synaptic plasticity. (
  • Specific PTPS activity was ≈3-fold higher in cytokine-treated HUVECs than in untreated cells. (
  • To determine the role and regulation of growth differentiation factor-15 (GDF-15), a TGF-β-related cytokine in human trabecular meshwork (TM) cells in the context of aqueous humor (AH) outflow and IOP. (
  • Murine clonal CD4 and CD8 T cells were stimulated with cognate peptide antigen and antigen presenting cells (APCs) in the absence or presence of human MSCs, different aspects of T cell activation were monitored and analyzed using flow cytometery, real time RT-PCR and cytokine measurement. (
  • Human MSCs (hMSCs) can alter multiple aspects of murine T cell activation induced by stimulation with specific antigen, including: reduced proliferation, inhibited or stimulated cell surface marker expression (CD25, CD69, CD44 and CD62L), inhibited mRNA expression of transcription factors (T-bet and GATA-3) and decreased cytokine expression (interferon-gamma, interleukin-10). (
  • Several pathogenic species, including bacteria and parasitic protozoans, actively modulate the production of nitric oxide by inducing their own arginases or the host's arginase activity to prevent the conversion of l -arginine to nitric oxide. (
  • We report here that C. albicans blocks nitric oxide production in human-monocyte-derived macrophages by induction of host arginase activity. (
  • Blocking the C. albicans -induced arginase activity with the arginase-specific substrate inhibitor N ω-hydroxy-nor-arginine (nor-NOHA) or the chitinase inhibitor bisdionin F restored nitric oxide production and increased the efficiency of fungal killing. (
  • This led to a reduced production of nitric oxide and, moreover, reduced eradication of the fungus by human macrophages. (
  • Importantly, weight loss in obese subjects normalizes PKCλ/ζ activation and increases IRS-1 phosphorylation and PI3K activity. (
  • Altogether these findings suggest that autophagy represents a pro-survival mechanism activated by GBM CSCs to counteract the efficacy of the anti-proliferative activity of GVS. (
  • Our findings indicate that human airway smooth muscle cells express and secrete MMP-12 that is up-regulated by IL-1beta and TNF-alpha. (
  • If the effect of sanctions can be detrimental for human rights, however, our argument and findings may imply a negative externality of the work of HROs that needs more attention from the practitioner community. (
  • HUVECs and human aortic SMCs (ATCC) were maintained in humidified air, 5% CO 2 at 37°C. Cells from passages 2 to 4 were seeded on 100-mm culture dishes in 10 mL of medium. (
  • In contrast to our previous data on Akt, reduced insulin-stimulated PKCλ/ζ activity could play a role in the pathogenesis of insulin resistance in muscle of obese and type 2 diabetic subjects. (
  • These data suggest a possible contribution of human chymase activation to LPS-induced mortality. (
  • These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir. (
  • The majority of data on insulin action in the brain was obtained in animal models, only few studies characterize insulin action in human brain. (
  • These data suggest that Src is pivotal for the formation and activity of human osteoclasts, probably through its effect on the distribution of the actin microfilament system. (
  • Using dyadic data on HROs and economic sanctions, we find robust support for our basic argument that HRO activities increase the likelihood of sanction events against repressive regimes. (
  • These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans. (
  • Normal human chondrocytes were stimulated with interleukin (IL)-1β for 6 h to induce MMP expression, simulating a catabolic state, and then treated with pravastatin (1, 5 and 10 μM) for a further 18 h before cell lysates and supernatants were harvested. (
  • Two unusual features of CCL14a are its constitutive expression in a large variety of tissues and its high plasma concentration, which ranges from 1.5 to 10 nM in normal human plasma ( 16 ). (
  • Upregulation of HO-1 gene expression by retrovirus-mediated delivery of the human HO-1 gene also attenuated heme and Ang II-induced prostaglandin synthesis. (
  • Thus, the expression and functional activity of this transporter may affect the rate of bile acid removal from the portal circulation. (
  • The plant extract also inhibited hyaluronidase expression in the cultured human chondrocyte cells in response to IL-1β (100 ng/ml). (
  • We also reported that the inhibitory effect of Payena dasyphylla on hyaluronidase activity and expression might be due to its anti-oxidant property. (
  • Scaling factors used in bridging the gap between expression systems and liver microsomes should not only incorporate relative hepatic abundance of individual CYPs but also account for differences in activity per unit enzyme in the two systems. (
  • Aims -To examine the distribution of iNOS in human colonic mucosa and to explore the ability of T lymphocyte derived cytokines to regulate iNOS expression and activity in human colonic epithelial cells. (
  • This study aimed to develop a feasible and efficient method for generating embryonic stem cell (ESC)-like induced pluripotent stem (iPS) cells from human Tenon's capsule fibroblasts (HTFs) through the expression of a defined set of transcription factors, which will have significant application value for ophthalmic personalized regenerative medicine. (
  • The resulting HTF-derived iPS cell colonies were indistinguishable from human ESC colonies regarding morphology, gene expression levels, pluripotent gene expression, alkaline phosphatase activity, and the ability to generate all three embryonic germ layers. (
  • Therefore, survival rate and chymase activity in the heart and skin were measured in transgenic mice carrying the human chymase gene [ 9 ]. (
  • The experiment was performed in male transgenic mice (18-20 weeks of age) carrying the human chymase gene (Tg) [ 9 ] and male wild-type C57BL/6 mice (WT). (
  • Using chromatin immunoprecipitation in human primary hepatocytes as well as electrophoretic mobility shift and luciferase reporter-gene assays, we identified three functional PPAR α -binding regions (PBR-I, -II, and -III) within ∼12 kb of the CYP3A4 upstream sequence. (
  • A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val 66 met) has been associated with abnormal intracellular trafficking and regulated secretion of BDNF in cultured hippocampal neurons transfected with the met allele. (
  • A frequent polymorphism producing a nonconservative amino acid substitution (valine to methionine) at codon 66 (val 66 met) has recently been identified in the human BDNF gene (dbSNP number rs6265). (
  • Considering the extended range of cancer-related pathways modulated by histone acetylation/deacetylation processes, we studied the anti-proliferative and pro-apoptotic efficacy of givinostat (GVS), a pan-histone deacetylase inhibitor, on cell cultures enriched in CSCs, isolated from nine human GBMs. (
  • Gravity is one of the important environmental factors that influence the physiologies and behaviors of animals and humans, and changes in gravity elicit a variety of physiological and behavioral alterations that include impaired movement coordination, vertigo, spatial disorientation, and perceptual illusions. (