Infections with bacteria of the genus STAPHYLOCOCCUS.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Antibiotic analog of CLOXACILLIN.
A persistent skin infection marked by the presence of furuncles, often chronic and recurrent. In humans, the causative agent is various species of STAPHYLOCOCCUS. In salmonid fish (SALMONIDS), the pathogen is AEROMONAS SALMONICIDA.
An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.
One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.
A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).
Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.
Substances that reduce the growth or reproduction of BACTERIA.
A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.
Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique to an inter-peptide cross-bridge of the STAPHYLOCOCCUS AUREUS cell wall. EC 3.4.24.75.
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Viruses whose host is Staphylococcus.
Skin diseases caused by bacteria, fungi, parasites, or viruses.
A semi-synthetic antibiotic related to penicillin.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages.
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).
A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.
Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
Any infection which a patient contracts in a health-care institution.
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Nonsusceptibility of an organism to the action of penicillins.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Bacterial polysaccharides that are rich in phosphodiester linkages. They are the major components of the cell walls and membranes of many bacteria.
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Glycopeptide antibiotic complex from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.
Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.
Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Catheters designed to be left within an organ or passage for an extended period of time.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Proteins found in any species of bacterium.
Infections with bacteria of the genus STREPTOCOCCUS.
Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Therapy with two or more separate preparations given for a combined effect.
Substances elaborated by bacteria that have antigenic activity.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Elements of limited time intervals, contributing to particular results or situations.

Clindamycin plus gentamicin as expectant therapy for presumed mixed infections. (1/7250)

The prevalence of obligate anaerobes was studied prospectively in 60 patients with severe sepsis of intra-abdominal, soft tissue, female genital or oropulmonary origin. In addition, the efficacy of clindamycin (for anaerobes) plus gentamicin (for aerobic bacteria, especially coliforms) as initial empiric therapy in these patients was evaluated. Among 54 patients with cultural proof of infection, anaerobic pathogens were recovered from 52%. Nineteen patients had bacteremia; Bacteroides fragilis and Klebsiella pneumoniae were the most prevalent pathogens, being isolated in five patients each. Infection was eradicated in 56 of the 60 patients (93%). Mortality related to sepsis was 7% in the entire group, 16% in patients with bacteremia and 2% in patients without bacteremia. Eighty-five percent of aerobic isolates tested were susceptible in vitro to either gentamicin or clindamycin; 97% of anaerobic isolates were inhibited by 5 mug/ml of clindamycin.  (+info)

Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (2/7250)

BACKGROUND: Since the emergence of methicillin-resistant Staphylococcus aureus, the glycopeptide vancomycin has been the only uniformly effective treatment for staphylococcal infections. In 1997, two infections due to S. aureus with reduced susceptibility to vancomycin were identified in the United States. METHODS: We investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 microg per milliliter. To assess the carriage and transmission of these strains of S. aureus, we cultured samples from the patients and their contacts and evaluated the isolates. RESULTS: The first patient was a 59-year-old man in Michigan with diabetes mellitus and chronic renal failure. Peritonitis due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus peritonitis associated with dialysis. The removal of the peritoneal catheter plus treatment with rifampin and trimethoprim-sulfamethoxazole eradicated the infection. The second patient was a 66-year-old man with diabetes in New Jersey. A bloodstream infection due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus bacteremia. This infection was eradicated with vancomycin, gentamicin, and rifampin. Both patients died. The glycopeptide-intermediate S. aureus isolates differed by two bands on pulsed-field gel electrophoresis. On electron microscopy, the isolates from the infected patients had thicker extracellular matrixes than control methicillin-resistant S. aureus isolates. No carriage was documented among 177 contacts of the two patients. CONCLUSIONS: The emergence of S. aureus with intermediate resistance to glycopeptides emphasizes the importance of the prudent use of antibiotics, the laboratory capacity to identify resistant strains, and the use of infection-control precautions to prevent transmission.  (+info)

Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis. (3/7250)

Septic arthritis is a common and feared complication of staphylococcal infections. Staphylococcus aureus produces a number of potential virulence factors including certain adhesins and enterotoxins. In this study we have assessed the roles of cytolytic toxins in the development of septic arthritis by inoculating mice with S. aureus wild-type strain 8325-4 or isogenic mutants differing in the expression of alpha-, beta-, and gamma-toxin production patterns. Mice inoculated with either an alpha- or beta-toxin mutant showed degrees of inflammation, joint damage, and weight decrease similar to wild-type-inoculated mice. In contrast, mice inoculated with either double (alpha- and gamma-toxin-deficient)- or triple (alpha-, beta-, and gamma-toxin-deficient)-mutant S. aureus strains showed lower frequency and severity of arthritis, measured both clinically and histologically, than mice inoculated with the wild-type strain. We conclude that simultaneous production of alpha- and gamma-toxin is a virulence factor in S. aureus arthritis.  (+info)

Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. (4/7250)

Fifty-nine consecutive patients with definite Staphylococcus aureus infective endocarditis (IE) by the Duke criteria were prospectively identified at our hospital over a 3-year period. Twenty-seven (45.8%) of the 59 patients had hospital-acquired S. aureus bacteremia. The presumed source of infection was an intravascular device in 50.8% of patients. Transthoracic echocardiography (TTE) revealed evidence of IE in 20 patients (33.9%), whereas transesophageal echocardiography (TEE) revealed evidence of IE in 48 patients (81.4%). The outcome for patients was strongly associated with echocardiographic findings: 13 (68.4%) of 19 patients with vegetations visualized by TTE had an embolic event or died of their infection vs. five (16.7%) of 30 patients whose vegetations were visualized only by TEE (P < .01). Most patients with S. aureus IE developed their infection as a consequence of a nosocomial or intravascular device-related infection. TEE established the diagnosis of S. aureus IE in many instances when TTE was nondiagnostic. Visualization of vegetations by TTE may provide prognostic information for patients with S. aureus IE.  (+info)

Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (5/7250)

The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia.  (+info)

Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus. (6/7250)

The acquisition of iron by pathogenic bacteria is often a crucial step in establishing infection. To accomplish this, many bacteria, including Staphylococcus aureus, produce low-molecular-weight iron-chelating siderophores. However, the secretion and transport of these molecules in gram-positive organisms are poorly understood. The sequence, organization, and regulation of genes involved in siderophore transport are conserved among gram-negative bacteria. We used this information to identify a putative siderophore transport locus from an S. aureus genomic sequence database. This locus contains three predicted open reading frames with a high degree of homology to genes involved in siderophore uptake in several bacterial species, in particular the cbr locus of the plant pathogen Erwinia chrysanthemi. The first gene in the locus, which we have designated sir for staphylococcal iron regulated, encodes a putative lipoprotein with a molecular mass of 37 kDa. The open reading frame is preceded by a 19-bp region of dyad symmetry with homology for operator sequences controlling iron-regulated expression of genes in other bacteria. Fur titration experiments indicate that this region of dyad symmetry is sufficient for Fur-dependent regulation in Escherichia coli. The expression of this gene was repressed, in a dose-dependent manner, by the addition of iron to the S. aureus culture medium. sir-encoded proteins may be involved in iron acquisition in vivo and therefore may be targets for antimicrobial agents.  (+info)

Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospital. (7/7250)

The susceptibility of two collections of coagulase-negative staphylococci (CNS) isolated from clinical specimens for teicoplanin and vancomycin were compared. They comprised 91 and 101 isolates, collected in 1985 and 1994 respectively, from different departments of a teaching hospital. MICs of vancomycin and teicoplanin were determined by a modified Etest method. Additionally, a disc diffusion test was performed for teicoplanin. All isolates were susceptible to vancomycin (MIC < or = 4 mg/L). Two of the 91 isolates collected in 1985 were intermediate to teicoplanin (MIC between 8 and 32 mg/L), whereas in 1994 the number of intermediate isolates was 20 out of 101 (P < 0.01). The correlation between MICs, as determined by the modified Etest assay, and disc diffusion zones was poor (r = -0.35). Results show that resistance to teicoplanin in CNS has increased in the study hospital over a period of 9 years. This increase is likely to be correlated with the introduction of teicoplanin. Furthermore, a disc diffusion method does not appear to be the first method of choice for detection of strains of CNS with diminished susceptibility to teicoplanin.  (+info)

The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (8/7250)

In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested.  (+info)

The aim of this study was to characterise invasive methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains from Italy and to investigate the presence of heteroresistant vancomycin-intermediate S. aureus (h-VISA). Eighty-two MSSA and 66 MRSA strains obt …
King and colleagues (1) cite clindamycin, trimethoprim-sulfamethoxazole, and linezolid as alternatives to vancomycin for outpatient treatment of localized skin and soft-tissue infections due to MRSA. However, they point out the uncertain efficacy of these agents in MRSA infections and the problem of inducible clindamycin resistance. Missing from this list of alternatives, and from the susceptibility data included in the paper and in the Editors Notes, are the tetracyclines, of which minocycline is the most potent against staphylococci and with which there is the most clinical experience in treating MRSA infections (2) ...
We found that most MRSA infections in the HNELHD are now acquired in the community, and that young people, Indigenous Australians, and residents of aged care facilities are disproportionally affected by CA-MRSA infections (Box 6). Fewer than half the patients with MRSA isolates had been hospitalised during the preceding 12 months, and more than one-third of S. aureus isolates from residents of aged care facilities were MRSA (Box 2).. The prevalence of multi-resistant MRSA decreased significantly across the study period, and non-multi-resistant MRSA phenotypes predominated in both community and health care settings. EMRSA-15-like strains predominated in CA-MRSA isolates from people in aged care facilities, and the highest proportion of non-multi-resistant phenotypes was for CA-MRSA isolates from patients in major metropolitan areas.. Our findings reflect progress in reducing HO-MRSA rates, with MRSA isolation rates declining in the two largest hospitals. Reduced HO-MRSA rates have been documented ...
This single-center, case-control study documents a relative increase in methicillin resistance among 48 cases of Staphylococcus aureus-associated postpartum mastitis during 1998-2005. Of 21 cases with methicillin resistance, 17 (81%) occurred in 2005. Twenty (95%) isolates contained the Staphylococcus cassette chromosome mec type IV gene; this suggests that the increase is due to community-acquired methicillin-resistant S. aureus ...
A 14-month-old infant was brought by his mother for evaluation of fever (temperature, 39.4ºC [103ºF]) and a tender, indurated, warm area with surrounding edema and a centrally located papule in the left groin.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
TY - JOUR. T1 - A child with Neisseria meningitidis endocarditis and Staphylococcus aureus septicaemia. AU - Venugopalan, P.. AU - Alexander, P. C.. AU - Aithala, G.. AU - Koul, R. L.. AU - Shenoy, A. K.. PY - 1999/12. Y1 - 1999/12. UR - http://www.scopus.com/inward/record.url?scp=0033388857&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033388857&partnerID=8YFLogxK. M3 - Article. C2 - 10667006. AN - SCOPUS:0033388857. VL - 45. SP - 360. EP - 361. JO - Journal of Tropical Pediatrics. JF - Journal of Tropical Pediatrics. SN - 0142-6338. IS - 6. ER - ...
with M. Blaser, Y-H. Hsieh, and J. Wu), Pre-symptomatic influenza transmission, surveillance, and school closings, published online, April 28, 2010, Math. Mod. Nat. Phen.. (with E.M.C. DAgata and J. Pressley), Rapid emergence of co-colonization with community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus strains in the hospital setting, published online, April 28, 2010, Math. Mod. Nat. Phen.. (with J. Dyson, S.A. Gourley, and R. Villella-Bressan), Existence and asymptotic properties of solutions of a nonlocal evolution equation modelling cell-cell adhesion, SIAM J. Math. Anal., Vol. 42, No. 4 (2010), 1784-1804.. (with E.M.C. DAgata and J. Pressley), The effect of co-colonization with community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus strains on competitive exclusion, J. Theoret. Biol., Vol. 264 (2010), 645-656.. (with B. Ayati, C. Edwards, and J. Wikswo), A mathematical model of bone remodeling dynamics for normal and tumor bone ...
We determined the agr type, multilocus sequence type, protein A gene type (spa typing), toxin gene profile, and antimicrobial drug resistance profile of 469 isolates of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates (PVL-positive CA-MRSA). The isolates had been collected from around the world from 1999 through 2005 by the French National Reference Center for Staphylococci. We found that some continent-specific clones described in 2003, such as clone ST8, have now spread all over the world. Likewise, some PVL-positive CA-MRSA have spread to several countries on various continents. New clones have emerged (e.g., ST377) on new genetic backgrounds. PVL-positive CA-MRSA that were usually susceptible to most antistaphylococcal antimicrobial agents have acquired new resistance determinants (e.g., to gentamicin) in certain countries. The major trait shared by all these clones is a short staphylococcal chromosomal cassette mec element of type ...
Recent CDC studies show that people who inject drugs are at high risk for dangerous, costly infections from skin bacteria and fungi. The CDC-funded Emerging Infections Programs Healthcare-Associated Infections/Community Interface found that people who inject drugs are at 16-times higher risk of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. Moreover, the proportion of invasive MRSA infections among people who inject drugs more than doubled from 2011 through 2016. Additional field investigations conducted by CDC staff in New York, New Mexico, and Colorado identified drug preparation or injection practices that greatly increase infection risk. This information is giving CDC and partners insights into how these dangerous infections can be prevented-for example, by educating people about wound care and early warning signs of serious infections associated with injection drug use.. CDC also teams up with partners to track emergency department (ED) visits and hospitalizations ...
CIDRAP News) - The latest data from the US Centers for Disease Control and Prevention (CDC) suggest that hospitals have cut their incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections in half since 2005, but the decline in community-associated MRSA infections has been far more modest. ...
CIDRAP News) - The latest data from the US Centers for Disease Control and Prevention (CDC) suggest that hospitals have cut their incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections in half since 2005, but the decline in community-associated MRSA infections has been far more modest. ...
SAN DIEGO-In dialysis patients, invasive methicillin-resistant Staphylococcus aureus (MRSA) infections occur much more frequently than in the general population, a study found.
Genus and species should be expanded and italicized in the title or subtitle and an initial capital letter should be used for the genus but not the species name, just as in the text. (See also , Nomenclature, Organisms and Pathogens, Biological Nomenclature.)Elimination of a Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection in a Nurse With Atopic Dermatitis |
Genus and species should be expanded and italicized in the title or subtitle and an initial capital letter should be used for the genus but not the species name, just as in the text. (See also , Nomenclature, Organisms and Pathogens, Biological Nomenclature.)Elimination of a Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection in a Nurse With Atopic Dermatitis |
Frank, L. A., Kania, S. A., Kirzeder, E. M., Eberlein, L. C. and Bemis, D. A. (2009), Risk of colonization or gene transfer to owners of dogs with meticillin-resistant Staphylococcus pseudintermedius. Veterinary Dermatology, 20: 496-501. doi: 10.1111/j.1365-3164.2009.00826.x ...
We conducted a retrospective, observational, population-based study to investigate the effect of staphylococcal infections on the hospitalization of children in California during 1985-2009. Hospitalized children with staphylococcal infections were identified through the California Office of Statewide Health Planning and Development discharge database. Infections were categorized as community onset, community onset health care-associated, or hospital onset. Infection incidence was calculated relative to all children and to those hospitalized in acute-care facilities. A total of 140,265 records were analyzed. Overall incidence increased from 49/100,000 population in 1985 to a peak of 83/100,000 in 2006 and dropped to 73/100,000 in 2009. Staphylococcal infections were associated with longer hospital stays and higher risk for death relative to all-cause hospitalizations of children. The number of methicillin-resistant Staphylococcus aureus infections increased, and the number of methicillin-susceptible S.
Staphylococci are among the most important human pathogens and a major cause of morbidity and mortality worldwide, causing septicaemia, pneumonia, endocarditis, osteomyelitis and post-operative infections. Among staphylococci, Staphylococcus aureus is regarded as the most virulent species, while S. epidermidis, once considered harmless, is emerging as an important agent of nosocomial infections, particularly in association with indwelling medical devices.The emergence of methicillin- and vancomycin- resistance among clinical isolates of S. aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies to prevent and treat staphylococcal infections especially in patients who are at high risk.The pathogenicity of staphylococci is due to the expression of a large plethora of virulence factors. Such determinants, which are mainly cell wall-associated and secreted proteins, include adhesins that confer to the pathogen the ability to attach
Staphylococcal infections in hospitals by Great Britain. Standing Medical Advisory Committee. Subcommittee on Staphylococcal Infections in Hospitals.; 1 edition; Subjects: Hospitals, Staphylococcal infections; Places: Great Britain
ICD-9 code 041.19 for Staphylococcus infection in conditions classified elsewhere and of unspecified site other staphylococcus is a medical classifica
Prior to the recent outbreak in Cedar Key, no one there had heard of Methicillin Resistant Staphylococcus aureus or MRSA, which is used to describe those examples of the organism that are resistant to commonly used antibiotics. Methicillin was an antibiotic used many years ago to treat patients with Staphylococcus infections. It is now no longer used except as a means of identifying this particular type of infection.
During the last decade staphylococcal infections have become a problem of increasing concern. Most of the acute bacterial infections of man respond promptly and predictably to the antimicrobial agents now available. Nevertheless, infections due to staphylococci have remained a serious therapeutic problem. It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials, although only a few studies to document this impression have appeared in the literature.9, 42, 64. Despite the apparent close biologic relationship between staphylococci and other gram-positive cocci which produce acute human infections, there is increasing evidence to suggest that staphylococci ...
The high recurrence rate of S. aureus skin and soft tissue (SSTI) caused by community-acquired methicillin-resistant S. aureus (CA-MRSA), suggests that long-lasting immunity is not generated in many individuals. If immune-based therapies are to provide an alternative to antibiotics, understanding the key immune responses that promote protection against CA-MRSA is essential. Previous reports in mice found that IL-17A/F production by γδ T cells mediated early neutrophil recruitment and host defense (within the first 24 hours) against a skin challenge with a methicillin-sensitive S. aureus laboratory strain. To elucidate the role of IL-17A/F in host defense against a CA-MRSA SSTI, IL-17A/F-deficient and wt mice were inoculated intradermally with a bioluminescent derivative of a CA-MRSA clinical isolate (USA300 LAC). Remarkably, IL-17A/F-deficient mice did not have an early immune defect, but rather they developed significantly larger lesions and increased bacterial burden compared with wt mice at days 7
McMurray, Claire Louise (2016) Factors influencing the nasal carriage by staphylococci. Ph.D. thesis, University of Birmingham.. Evans, Jason Thomas (2012) Molecular epidemiology of tuberculosis in the Midlands. Ph.D. thesis, University of Birmingham.. Smith, Helen Elizabeth (2013) The interrelationship of strain diversity, virulence and patient ethnicity for tuberculosis in the Midlands, UK. Ph.D. thesis, University of Birmingham.. Thomson, Calum Bryson (2017) The molecular epidemiology and characteristics of methicillin resistant Staphylococcus aureus sequence type 22 in a local, national and international context. Ph.D. thesis, University of Birmingham.. ...
Global Staphylococcal Infection Drugs Market 2019 by Company, Regions, Type and Application, Forecast to 2024 is an inclusive, professional analysis which demonstrates Staphylococcal Infection Drugs market data. The report covers data that makes the record a resource for analysts, managers, industry experts as well as important people. The report involves key insights pertaining to industry deliverables, particularly market trends, market share, market competitors and recognized players, market size, current valuation, and revenue estimations for the forecast period. It then identifies the market growth rate during the forecast timeline. The report has forecast the strong rise of this market in product sections and every geography. Additionally, the foremost challenges and growth opportunities are presented in the research study.. DOWNLOAD FREE SAMPLE REPORT: https://www.mrinsights.biz/report-detail/185155/request-sample Moreover, assessment of the technical barriers, other issues, as well as ...
Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life-threatening and are frequently complicated by multi-antibiotic resistant strains including methicillin-resistant S. aureus (MRSA). Fluorodeoxyglucose ([18F]FDG) imaging has been used to identify infection sites; however, it is unable to distinguish between sterile inflammation and bacterial load. We have modified [18F]FDG by phosphorylation, producing [18F]FDG-6-P to facilitate specific uptake and accumulation by S. aureus through hexose phosphate transporters, which are not present in mammalian cell membranes. This approach leads to the specific uptake of the radiopharmaceutical into the bacteria and not the sites of sterile inflammation. [18F]FDG-6-P was synthesised from [18F]FDG. Yield, purity and stability were confirmed by RP-HPLC and iTLC. The specificity of [18F]FDG-6-P for the bacterial
Dyon-Tafani, V. ; Lefort, S. ; Josse, J. ; Valour, F. ; Diot, A. ; Sabuco, J.F. ; Coyne, S. ; Ferry, T. ; Mourez, M. ; Laurent, F ...
emscope:(USP_PRODUCAO),scope:(USP_EBOOKS),scope:(PRIMO),scope:(USP),scope:(USP_EREVISTAS),scope:(USP_FISICO),primo_central_multiple_fe ...
Staphylococcal (staph) infections are common in the skin but can spread to deeper tissues, causing serious complications including sepsis. Learn about the symptoms, treatment and why its important to seek medical advice here - using content verified by certified doctors.
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This is a highly useful study on several axes. First, remarkably, there has not been agreement over whether and how much of a problem MRSA poses in post-surgical settings, particularly when compared to drug-sensitive staph. This study provides careful, thoughtful, well-documented proof that combating MRSA infection is worthwhile. (NB, MRSA infections did not increase the risk of death relative to MSSA infections, which should remind us both of the often-forgotten virulence of MSSA, and also that MRSAs perils can lie in extended illness and disability as much or more as in early death.) Second, by putting a very specific number on the cost of a post-surgical MRSA infection, it gives healthcare administrators a benchmark against which they can judge the cost of a prevention program. Weve all heard complaints that prevention programs can be costly and their benefit is hard to measure in a bottom-line way. With this very specific number, that complaint should no longer be valid ...
MRSA is a super-scary, drug-resistant staph infection, and even Peyton Manning suffered, as I reported recently. MRSA is one of the superbugs, which a...
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Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that causes serious infectious diseases and was endemic in hospitals by the late 1960s. Beginning with its first report in the late 1990s, the rapid emergence of community-associated MRSA (CA-MRSA) worldwide responsible for a wide spectrum of diseases ranging from minor skin infections to fatal necrotizing pneumonia has been found in previously healthy individuals without established risk factors for MRSA acquisition. Recently, various virulence determinants unique to CA-MRSA have been uncovered, which explain how the pathogen spreads easily and causes severe CA-MRSA infections among humans. However, the role of Panton-Valentine leukocidin (PVL) in the pathogenesis of CA-MRSA infection is currently a matter of much debate because of conflicting data from epidemiologic studies of CA-MRSA infections and various murine disease models. Identifying specialized pathogenic traits of CA-MRSA and the concerted regulation of ...
Characterization and Comparison of 2 Distinct Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus Clones of ST59 ...
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 has spread rapidly across North America, and CA-MRSA is also increasing in Australia. However, the dominant Australian CA-MRSA strain, ST93-IV [2B] appears distantly related to USA300 despite strikingly similar clinical and epidemiological profiles. Here, we compared the virulence of a recent Australian ST93 isolate (JKD6159) to other MRSA, including USA300, and found that JKD6159 was the most virulent in a mouse skin infection model. We fully sequenced the genome of JKD6159 and confirmed that JKD6159 is a distinct clone with 7616 single nucleotide polymorphisms (SNPs) distinguishing this strain from all other S. aureus genomes. Despite its high virulence there were surprisingly few virulence determinants. However, genes encoding a-hemolysin, Panton-Valentine leukocidin (PVL) and a-type phenol soluble modulins were present. Genome comparisons revealed 32 additional CDS in JKD6159 but none appeared to encode new ...
Community-associated methicillin-resistant Staphylococcus aureus (MRSA) was first reported in Western Australia in the early 1990s from indigenous peoples living in remote areas. Although a statewide policy of screening all hospital patients and staff who have lived outside the state for MRSA has prevented the establishment of multidrug-resistant epidemic MRSA, the policy has not prevented SCCmec type IV and type V MRSA clones from becoming established. Of the 4,099 MRSA isolates analyzed (referred to the Gram-positive Bacteria Typing and Research Unit) from July 2003 to December 2004, 77.5% were community-associated MRSA (CA-MRSA). Using multilocus sequence/staphylococcal chromosome cassette mec typing, 22 CA-MRSA clones were characterized. Of these isolates, 55.5% were resistant to ,1 non-β-lactam antimicrobial drug. Five Panton-Valentine leukocidin (PVL)-positive CA-MRSA clones were identified. The emergence of multidrug-resistant CA-MRSA clones and the detection of PVL toxin genes in clones ...
Boucher, H, Miller, L, Razonable, R. Serious infections caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis. vol. 51. 2010. pp. S183-S197. Miller, LG, Perdreau-Remington, F, Rieg, G, Mehdi, S, Perlroth, J, Bayer, A, Tang, A, Phung, T, Spellberg, B. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Eng J Med. vol. 352. 2005. pp. 1445-1453. Cosgrove, SE, Fowler, VG. Optimizing therapy for methicillin-resistant Staphylococcus aureus bacteremia. Semin Respir Crit Care Med. vol. 28. 2007. pp. 624-631. Moran, GJ, Krishnadasan, A, Gorwitz, RJ, Fosheim, G, McDougal, LK, Carey, R, Talan, D. Methicillin- resistant Staphylococcus aureus infections among patients in the emergency department. N Eng J Med. vol. 355. 2006. pp. 666-674. Gordon, RJ, Lowy, FD. Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. vol. 46. 2008. pp. S350-S359. Bishara, J, Leibovici, L, Gartman-Israel, D, ...
Adcock PM, Pastor P, Medley F, Patterson JE, Murphy TV. 1998. Methicillin-resistant Staphylococcus aureus in two child care centers. J Infect Dis 178(2):577-580.. Bhat M, Dumortier C, Taylor BS, Miller M, Vasquez G, Yunen J, et al. 2009. Staphylococcus aureus ST398, New York City and Dominican Republic. Emerg Infect Dis 15(2):285-287.. Bosch T, van Luit M, Pluister GN, Frentz D, Haenen A, Landman F, et al. 2016. Changing characteristics of livestock-associated meticillin-resistant Staphylococcus aureus isolated from humans - emergence of a subclade transmitted without livestock exposure, the Netherlands, 2003 to 2014. Euro Surveill 21(21), doi: 10.2807/1560-7917.ES.2016.21.21.30236.. Chen AE, Cantey JB, Carroll KC, Ross T, Speser S, Siberry GK. 2009. Discordance between Staphylococcus aureus nasal colonization and skin infections in children. Pediatr Infect Dis J 28(3):244-246.. CLSI (Clinical and Laboratory Standards Institute). 2015. Performance Standards for Antimicrobial Disk Susceptibility ...
Difficult-to-treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are of concern in people living with HIV infection as they are m
TY - JOUR. T1 - In vitro efficacy of antimicrobial agents against high-inoculum or biofilm-embedded meticillin-resistant Staphylococcus aureus with vancomycin minimal inhibitory concentrations equal to 2 μg/mL (VA2-MRSA). AU - Tang, Hung Jen. AU - Chen, Chi Chung. AU - Ko, Wen Chien. AU - Yu, Wen Liang. AU - Chiang, Shyh Ren. AU - Chuang, Yin Ching. PY - 2011/7. Y1 - 2011/7. N2 - Minimal inhibitory concentration (MIC) creep in meticillin-resistant Staphylococcus aureus (MRSA) isolates has been observed in recent years. The potential roles of vancomycin-based combination regimens as well as linezolid and tigecycline against five clinical MRSA isolates with vancomycin MICs of 2 μg/mL (VA2-MRSA) were evaluated and compared in vitro. Antimicrobial susceptibility was studied by the agar dilution method. Anti-MRSA activities of linezolid, tigecycline, vancomycin, minocycline, rifampicin and fosfomycin alone as well as of three vancomycin-based combinations were studied by time-kill method and using ...
The epidemic of USA300-0114 methicillin-resistant Staphylococcus aureus (MRSA) in the USA has been remarkable for its virulence and for its ability to cause infections in both the community and healthcare settings. Although it has mainly been associated with skin and soft tissue infections, particularly furunculosis, it has also caused severe life-threatening conditions such as necrotizing pneumonia, osteomyelitis, and septic arthritis. This strain or a closely related Latin American variant has now spread to multiple countries on five continents, where associated clinical and epidemiological features have been in keeping with those seen in the USA. Furthermore, it has become the dominant community-associated MRSA strain in five countries. It is now a major international epidemic strain, but whether it will supplant established community-associated strains in other countries remains to be seen ...
Background. Staphylococcus aureus bloodstream infection (SABSI) arising from a urinary tract source (UTS) is poorly understood. Methods. We conducted a retrospective analysis in 3 major teaching hospitals in Spain of prospectively collected data of hospitalized patients with SABSI. SABSI-UTS was diagnosed in patients with urinary tract symptoms and/or signs, no evidence of an extra-urinary source of infection, and a urinary S. aureus count of ,= 10(5) cfu/mL. Susceptibility of S. aureus strains and patient mortality were compared between SABSI from UTS (SABSI-UTS) and other sources (SABSI-other). Results. Of 4181 episodes of SABSI, we identified 132 (3.16%) cases of SABSI-UTS that occurred predominantly in patients who were male, had high Charlson comorbidity scores, were dependent for daily life activities, and who had undergone urinary catheterization and/or urinary manipulation before the infection. SABSI-UTS was more often caused by MRSA strains compared with SABSI-other (40.9% vs 17.5%; P , ...
This MyHospitals web update presents information [email protected] Staphylococcus aureus bloodstream infections for 677 Australian public hospitals and around 70 private hospitals in [email protected]
Report Publication; Hospital Performance: Healthcare-associated Staphylococcus aureus bloodstream infections in 2015-16, In Focus ; Released 2017; Golden Staph
Background Community-Associated Methicillin Resistant Staphylococcus aureus(CA-MRSA) has traditionally been related to skin and soft tissue infections in healthy young patients. However, it has now...
CAMERA2-combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial Journal Articles Refereed ...
The reports market outlook delivers an understanding of the country-specific revenue and share by analyzing the performance of the current therapies and potential uptake of new products. The in-depth analysis helps to recognize the growing demand of the market by evaluating the annual cost of therapy, compliance rate, competition with other therapies, covered patient segment, impact of emerging technology in the forecast period. The views from the key opinion leaders adds more value to the analysis. This segment provides the relevant graphs and tables to have an effective outline of the Hospital Acquired Methicillin-Resistant Staphylococcus Aureus Infections market ...
Hospital Acquired Methicillin-Resistant Staphylococcus Aureus Infections Pipeline 2017, report provides comprehensive insights about marketed and pipeline drugs across this Mechanism of action.
TY - JOUR. T1 - Staphylococcus aureus colonization among healthcare workers at a tertiary care hospital. AU - Johnston, Cecilia P.. AU - Stokes, Amy K.. AU - Ross, Tracy. AU - Cai, Mian. AU - Carroll, Karen C.. AU - Cosgrove, Sara E.. AU - Perl, Trish M.. PY - 2007/12. Y1 - 2007/12. N2 - We describe the epidemiology of Staphylococcus aureus colonization among 200 healthcare workers. The prevalence of S. aureus was 28%, and the prevalence of methicillin-resistant S. aureus (MRSA) was 2%. The incidence of MRSA colonization was extremely low. This study suggests that the risk of MRSA transmission to healthcare workers is low in a hospital where MRSA is endemic.. AB - We describe the epidemiology of Staphylococcus aureus colonization among 200 healthcare workers. The prevalence of S. aureus was 28%, and the prevalence of methicillin-resistant S. aureus (MRSA) was 2%. The incidence of MRSA colonization was extremely low. This study suggests that the risk of MRSA transmission to healthcare workers is ...
Defining the burden of morbidity and mortality due to invasive staphylococcus aureus disease and the Impact of drug resistance in Thailand ...
TY - JOUR. T1 - Should healthcare workers be screened routinely for meticillin-resistant Staphylococcus aureus? A review of the evidence. AU - Hawkins, G.. AU - Stewart, S.. AU - Blatchford, O.. AU - Reilly, Jacqui. N1 - ,p,Originally published in: Journal of Hospital Infection (2011), 77 (4), pp.285-289.,/p,. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Meticillin-resistant Staphylococcus aureus (MRSA) is considered endemic in the UK National Health Service (NHS), and routine MRSA screening of hospital inpatients has recently been introduced in both Scotland and England. The UK National Screening Committee states that public pressure for widening the eligibility criteria of a proposed screening programme should be anticipated and any related decisions scientifically justifiable. A literature review was conducted to examine whether MRSA screening in Scotland should be expanded to include the routine screening of healthcare workers (HCWs). There are no published prevalence studies reporting the overall ...
Objective: Increasing length of hospital stay is associated with methicillin‐resistant Staphylococcus aureus (MRSA) acquisition. The exact risk of becoming colonized with MRSA on a given day has not been clearly elucidated. We determined the hazard of MRSA acquisition in relation to the length of time spent in an intensive care unit in which only standard precautions were used for MRSA‐colonized and MRSA‐infected patients.. Methods: This study took place at a tertiary referral hospital intensive care unit in which patients were screened for MRSA at hospital admission, at hospital discharge, and twice weekly during intensive care unit stay. We analyzed the hazard of MRSA acquisition by using a statistical smoothing kernel for hazard with a width of 5 days. Patients were stratified according to age, sex, medical unit, and length of hospital stay.. Results: Of the patients who were at risk of colonization or infection, 12.8% acquired MRSA. The mean length of stay in the intensive care unit ...
Here are some True/False questions on Staphylococcus aureus. Click at the bottom of the page for answers and short explanations.. 1) Most people are colonised with Staphylococcus aureus? T/F. 2) The nuc gene is found in Methicillin Resistant Staphylococcus aureus? T/F. 3) Methicillin is a commonly used antibiotic in many parts of the world? T/F. 4) Staphylococcus aureus can ferment mannitol? T/F. 5) Coagulase is not thought to be an important virulence factor for Staphylococcus aureus? T/F. 6) Staphylococcus aureus bacteraemia has a 30 day mortality of 15-20%? T/F. 7) Staphylococcus aureus can cause food poisoning? T/F. 8) Staphylococcus aureus is a motile organism? T/F. 9) Staphylococcus aureus can be intracellular in nasal epithelial cells? T/F. 10) Staphylococcus aureus is acommon contaminant in blood cultures? T/F. Click here for answers and short explanations. ...
Blumenthal KG, Shenoy ES, Huang M, Kuhlen JL, Ware WA, Parker RA, Walensky RP. The Impact of Reporting a Prior Penicillin Allergy on the Treatment of Methicillin-Sensitive Staphylococcus aureus Bacteremia. PLoS One. 2016; 11(7):e0159406 ...
Background: Early identification of meticillin-resistant Staphylococcus aureus (MRSA) carriers may be helpful for clinical and epidemiological reasons. Aim: To identify and compare risk factors of previously unknown MRSA carriage on admission to 13 surgical wards in France, Greece, Italy, and Spain. Methods: The study was a prospective observational cohort study which enrolled consecutive patients screened for MRSA on admission to surgical wards. Sociodemographic data, comorbidities and possible risk factors for MRSA were recorded. A multivariate logistic regression model was used to predict probabilities of previously unknown MRSA colonization on admission based on patient characteristics. Prediction rules for MRSA carriage were developed and evaluated using the c-statistic. Findings: Of 2901 patients enrolled, admission screening identified 111 (3.8%) new MRSA carriers. Independent risk factors for MRSA carriage were urinary catheterization (odds ratio: 4.4; 95% confidence interval: 2.0-9.9), nursing
Meticillin-resistant Staphylococcus aureus (MRSA) bloodstream infection is responsible for significant morbidity, with mortality rates as high as 60 % if not treated appropriately. We describe a rapid method to detect MRSA in blood cultures using a combined three-hour short-incubation BRUKER matrix-assisted laser desorption/ionization time-of-flight MS BioTyper protocol and a qualitative immunochromatographic assay, the Alere Culture Colony Test PBP2a detection test. We compared this combined method with a molecular method detecting the nuc and mecA genes currently performed in our laboratory. One hundred and seventeen S. aureus blood cultures were tested of which 35 were MRSA and 82 were meticillin-sensitive S. aureus (MSSA). The rapid combined test correctly identified 100 % (82/82) of the MSSA and 85.7 % (30/35) of the MRSA after 3 h. There were five false negative results where the isolates were correctly identified as S. aureus, but PBP2a was not detected by the Culture Colony Test. The combined
Humans and several other mammals harbor Staphylococcus aureus as a component of their nasal and skin microbiome. Although this organism is a commensal in 25 to 33% of humans in developed countries (1), it can cause opportunistic infections that range in severity from mild skin infections to severe systemic infections (2, 3). Treatment of these infections is challenging due to the rapid acquisition of antimicrobial resistance genes, including the staphylococcal cassette chromosome mec element (SCCmec) element, which carries the mecA gene, conferring methicillin resistance (4, 5). These isolates, deemed methicillin-resistant S. aureus (MRSA), have become a significant public health burden in the United States, annually causing thousands of infections, which result in significant health care costs and losses in productivity (6, 7).. MRSA isolates are classified by the source from which they are acquired to form the following categories: hospital-acquired MRSA (HA-MRSA), community-acquired MRSA ...
Because of high incidence, morbidity, and antimicrobial resistance, Staphylococcus aureus infections are a growing concern for family physicians. Strains of S. aureus that are resistant to vancomycin are now recognized. Increasing incidence of unrecognized community-acquired methicillin-resistant S. aureus infections pose a high risk for morbidity and mortality. Although the incidence of complex S. aureus infections is rising, new antimicrobial agents, including daptomycin and linezolid, are available as treatment. S. aureus is a common pathogen in skin, soft-tissue, catheter-related, bone, joint, pulmonary, and central nervous system infections. S. aureus bacteremias are particularly problematic because of the high incidence of associated complicated infections, including infective endocarditis. Adherence to precautions recommended by the Centers for Disease Control and Prevention, especially handwashing, is suboptimal.
Staphylococcus aureus is one of the leading causes of bloodstream infection, and these infections still have a high mortality. In certain clinical situations and for the planning of future prophylactic precautions, it is important to identify patients at risk of S. aureus bloodstream infection. Nearly all patients with S. aureus bloodstream...
TMP-SMX: TMP-SMX is a potentially useful bactericidal antibiotic used for the treatment of CA-MRSA infections. Although this agent is not FDA approved for the general treatment of staphylococcal infections, several successful cases of its use as MRSA treatment have been reported.10,15 TMP-SMX is a two-component antibiotic that works through inhibition of folic acid synthesis at two separate pathways, thereby inhibiting bacterial DNA synthesis.24 Although large, randomized studies have yet to be conducted to directly evaluate TMP-SMXs efficacy in CA-MRSA, a recent literary analysis of reported data proposed its potential use in high dosages for susceptible MRSA isolates. The analysis concluded that TMP-SMX was useful for a majority of patients and, therefore may therefore be especially beneficial as an oral option for patients with susceptible isolates.10 Conversely, another small retrospective analysis that reviewed 39 outpatients with MRSA infections found a higher rate of recurrence in the ...
Global Markets Directs, Vancomycin Resistant Staphylococcus Aureus Infection (VRSA) - Pipeline Review, H2 2014, provides an overview of the Vancomycin Resistant Staphylococcus Aureus Infection
BACKGROUND This study was conducted to evaluate the ongoing transmission of methicillin-resistant Staphylococcus aureus (MRSA) in a 10-bed trauma intensive care unit (TICU) in a large teaching hospital. METHODS Surveillance cultures for MRSA were obtained on admission to the TICU. Colonized or infected patients were placed on contact precautions. On February 21, 2003, 19 burn patients were admitted to the TICU after a local mass casualty event. Universal barrier precautions were implemented for all patients, and point-prevalence surveys (nares cultures) were used to detect MRSA acquisition. RESULTS During March 2003, 58% of the burn patients developed MRSA infection or colonization. Six of 133 health care workers (HCWs) had positive MRSA screening cultures. Seven patients and 4 HCWs harbored the pulsed-field gel electrophoresis clone A. Two patients and 1 HCW harbored clone B. Once the colonized HCWs were successfully decolonized, a sustained reduction in MRSA infections occurred. CONCLUSION
The role of IFN-gamma in the regulation of host resistance of Staphylococcus aureus was studied using IFN-gamma receptor-deficient (IFN-gamma R-/-) mice in a model of S. aureus-induced septicemia and arthritis. IFN-gamma R-/- mice and wild-type controls were inoculated intravenously with a toxic shock syndrome toxin-1-producing S. aureus LS-1 strain. IFN-gamma R-/- mice displayed significantly more frequent and more severe arthritis compared with wild-type littermates (p , 0.01) throughout the course of infection. Notably, IFN-gamma R-/- mice developed severe sepsis with high mortality early after the inoculation with staphylococci. However, the mortality of wild-type mice became significantly higher at later stages of the disease compared with IFN-gamma R-/- mice (p , 0.05). This differential outcome of sepsis-related mortality was associated with deficiencies of bacterial elimination from blood and parenchymatous organs and correlated well to serum levels of IL-6 and spleen IL-1 beta and ...
Trends in Staphylococcus aureus infections are not well described. To calculate incidence in overall S. aureus infection and invasive and noninvasive infections according to methicillin susceptibility and location, we conducted a 10-year population-based retrospective cohort study (1999-2008) using patient-level data in the Veterans Affairs Maryland Health Care System. We found 3,674 S. aureus infections: 2,816 (77%) were noninvasive; 2,256 (61%) were methicillin-resistant S. aureus (MRSA); 2,517 (69%) were community onset, and 1,157 (31%) were hospital onset. Sixty-one percent of noninvasive infections were skin and soft tissue infections; 1,112 (65%) of these were MRSA. Ten-year averaged incidence per 100,000 veterans was 749 (± 132 SD, range 549-954) overall, 178 (± 41 SD, range 114-259) invasive, and 571 (± 152 SD, range 364-801) noninvasive S. aureus infections. Incidence of all S. aureus infections significantly increased (p&lt;0.001), driven by noninvasive, MRSA, and community
This case reports the presence of meticillin-resistant Staphylococcus aureus (MRSA) in a colony of cetaceans maintained under human care. MRSA isolates of the same strain were cultured from multiple organs of two dolphins that died with septicaemia. Following these mortalities and in consideration of the zoonotic potential of this pathogen, a decolonisation protocol was developed and applied to reduce the risk of exposure to humans and animals. After monitoring for MRSA presence in the animals, environment and staff, a strict sanitation protocol was applied for 15 months, with the aim of controlling MRSA. This protocol reduced the incidence of this pathogen and its involvement in acute clinical cases. The transmission between cetaceans and the implication of human reservoirs are discussed as important issues for veterinarians, facility managers and public health officials. ...
Staphylococcus aureus nasal carriage is a risk factor for subsequent infection. Estimates of colonization duration vary widely among studies, and factors
METHODS:. A total of 19 S. hominis isolates were collected from children at the Childrens Medical Centre, Tehran, Iran, from March 2012 to February 2013. MRSHo susceptibility against 13 antimicrobial and 3 antiseptic agents was determined using disk diffusion (DAD) and minimum inhibitory concentration (MIC), respectively. All isolates were subjected to polymerase chain reaction (PCR) assay for 15 distinct resistance genes, staphylococcal cassette chromosome mec (SCCmec), and arginine catabolic mobile elements (ACMEs). Biofilm production of the isolates was determined using a colorimetric microtiter plate assay. ...
In this study, we aimed to investigate the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus pseudintermedius (MRSP) clinical and colonizing isolates of dogs and cats to profile contributing factors associated with their isolation. Nasal and rectal samples were collected from dogs and cats between 2015 and 2017 to identify colonizing isolates. Clinical isolates collected between 2003 and 2016 were retrieved from a Queensland university veterinary diagnostic laboratory. All isolates were identified using standard microbiological and molecular methods and were characterized by whole genome sequencing. Phylogenetic relationships and differences in epidemiological factors were investigated. Seventy-two MRSP isolates out of 1,460 colonizing samples and nine MRSP clinical isolates were identified. No MRSA was isolated. ST496 and ST749 were the most commonly isolated sequence types with different SCCmec types. ST496 clones spread both ...
The methicillin-resistant Staphylococcus aureus (MRSA) population in the Hospital Universitario Nuestra Se ora de Candelaria over a 5-year period (1998 to 2002) was marked by shifts in the circulation of pandemic clones. Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mupr). In addition to clonal spread, transfer of ileS2-carrying plasmids played a significant role in the dissemination of Hi-Mupr among pandemic MRSA lineages. Most hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) isolates are members of five MRSA pandemic lineages or clonal complexes (CCs), namely, CC5, CC8, CC22, CC30, and CC45. Mupirocin constitutes the cornerstone of avoidance of MRSA carriage and ulterior infection, but resistance has emerged, and its spreading is worrisome, with transferable high-level mupirocin resistance (Hi-Mupr) being of clinical significance. Hi-Mupr is associated with an additional isoleucyl-tRNA synthetase that is encoded by the ileS2 gene. The ileS2 gene ...
Background. The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear. Methods. Three hundred seventy-nine S. aureus isolates (125 methicillin-resistant S. aureus [MRSA] and 254 methicillin-susceptible S. aureus [MSSA]) were genotyped by spa typing and multilocus sequence typing. For MRSA isolates, the staphylococcal chromosomal cassette mec (SCCmec) element was also typed. Three clinical categories were identified: nasal carriage only (n = 118), uncomplicated infection (n = 104), and bacteremia with hematogenous complications (n =157). Results. By use of eBURST, 18 clonal complexes (CCs) were found in 371 isolates. Eight CCs accounted for 89% of isolates and occurred in all clinical categories. CC5 (P = .0025) and CC30 (P = .0308) exhibited a significant trend toward more frequent hematogenous complications. Isolates within spa types 2 and 16 showed the same significant trend and grouped within CC5 and CC30, respectively. SCCmec II isolates also showed the same ...
BioAssay record AID 569544 submitted by ChEMBL: Ratio of compound MIC to LVFX MIC for methicillin-sensitive Staphylococcus aureus 10-04.
The objective of this study was to assess in vitro the antimicrobial activity of ethanolic extract of Polish propolis (EEPP) against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. The combined effect of EEPP and 10 selected antistaphylococcal drugs on S. aureus clinical cultures was also investigated. EEPP composition was analyzed by a High Performance Liquid Chromatography (HPLC) method. The flavonoid compounds identified in Polish Propolis included flavones, flavonones, flavonolols, flavonols and phenolic acids. EEPP displayed varying effectiveness against twelve S. aureus strains, with minimal inhibitory concentration (MIC) within the range from 0.39 to 0.78 mg/mL, determined by broth microdilution method. The average MIC was 0.54 ± 0.22 mg/mL, while calculated MIC50 and MIC90 were 0.39 mg/mL and 0.78 mg/mL, respectively. The minimum bactericidal concentration (MBC) of the EEPP ranged from 0.78 to 3.13 mg/mL. The in vitro
OBJECTIVE To evaluate leptomeningeal and subpial inflammatory responses of experimental Staphylococcus aureus bacteriemia following intraperitoneal and intravenous applications and to compare the inflammatory reactions in different regions of central nervous system. MATERIAL AND METHODS Forty anesthetized rats were divided into four groups equal in number. The rats in group-I were given 1 ml suspension of Staphylococcus aureus intraperitoneally. Group-II was the control group of group I; it was administrated 1 ml 0.9% NaCl in water intraperitoneally. The rats in group-III were given the same amount of bacteria intravenously. Group IV was the control group of the group-III; it was administrated 1 ml 0.9% NaCl solution intravenously. The rats were sacrificed on the 21st day. Inflammatory changes of different regions of the central nervous system were examined under transmission electron microscopy. Statistical analysis was done by using variance analysis, Bonferroni, Tamhane post hoc, Students t and
The purpose of this study was to evaluate the antibiotic susceptibility of clinically significant Staphylococcus aureus and its association with biofilm production. The antibiotic resistance pattern and biofilm production by S. aureus isolated from invasive sites such as deep tissue and bone, deep seated pus, blood and other sterile body fluids were studied. The prevalence of multidrug resistant strains and the associated risk factors and co-morbidities were noted. Samples were subjected to antibiotic susceptibility testing using modified Kirby-Bauer disc diffusion method and biofilm production was detected by using microtiter plate assay. Of the total 80 clinically significant invasive S. aureus strains, resistance to penicillin was observed in 70(88.6%) isolates and 38 (47.5%) isolates were resistant to cephalothin. Resistance to erythromycin was observed in 42(52.5%) isolates and 14(17.5%) isolates were resistant to clindamycin. Resistance to ciprofloxacin was 79.5%(n=63). Resistance to ...
Introduction Recently a specific MRSA sequence type, ST398, emerged in food production animals and farmers. Risk factors for carrying MRSA ST398 in both animals and humans have not been fully evaluated. In this cross-sectional study, we investigated factors associated with MRSA colonization in veal calves and humans working and living on these farms. Methods A sample of 102 veal calf farms were randomly selected and visited from March 2007-February 2008. Participating farmers were asked to fill in a questionnaire (n = 390) to identify potential risk factors. A nasal swab was taken from each participant. Furthermore, nasal swabs were taken from calves (n = 2151). Swabs were analysed for MRSA by selective enrichment and suspected colonies were confirmed as MRSA by using slide coagulase test and PCR for presence of the mecA-gene. Spa types were identified and a random selection of each spa type was tested with ST398 specific PCR. The Sequence Type of non ST398 strains was determined. Data were analyzed
TY - JOUR. T1 - Identification of β-lactamases in human and bovine isolates of Staphylococcus aureus strains having borderline resistance to penicillinase-resistant penicillins (PRPs) with proteomic methods. AU - Keseru, Judit Szilvia. AU - Szabó, István. AU - Gál, Zsuzsanna. AU - Massidda, Orietta. AU - Mingoia, Marina. AU - Kaszanyitzky, Éva. AU - Jánosi, Szilárd. AU - Hulvely, Julianna. AU - Csorba, Attila. AU - Buzás, Krisztina. AU - Hunyadi-Gulyás, Éva. AU - Medzihradszky, Katalin F.. AU - Biró, Sándor. PY - 2011/1/10. Y1 - 2011/1/10. N2 - Methicillin and oxacillin-hydrolyzing enzymes of 6 borderline methicillin-resistant and 1 methicillin-resistant Staphylococcus aureus strains isolated from human clinical samples and 4 borderline methicillin-resistant S. aureus strains isolated from bovine mastitis were investigated. As previous studies suggested the involvement of an additional enzyme besides the penicillinase BlaZ in the determination of borderline resistance, we analyzed ...
Community-associated methicillin-resistant Staphylococcus aureus infections in Aboriginal children attending hospital emergency departments in a regional area of New South Wales, Australia: a seven-year descriptive study - Thomas, Susan, Crooks, Kristy, Islam, Fakhrul, Massey, Peter D. ...
By Achim J. Kaasch, Gavin Barlow, Jonathan D. Edgeworth, Vance G. Fowler, Martin Hellmich, Susan Hopkins, Winfried V. Kern, Martin J. Llewelyn, Siegbert Rieg, Jesús Rodriguez-Baño, Matthew Scarborough, Harald Seifert, Alex Soriano, Robert Tilley, M. Estée Tőrők, Verena Weiß, A.Peter R. Wilson and Guy E. Thwaites ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Researchers at TGen and the United States Centers Disease Control and Prevention (CDC) have collaboratively developed a panel of assays for rapidly and consistently typing Staphylococcus aureus strains, and subtyping the strains within clonal complex 8 (CC8). The developed technology is an improvement over previously used typing methods and can be used as a method for source tracking of the bacteria within a facility (e.g., hospitals, medical service centers) to perform surveillance of infections and determine the origin of the infections. The efficient typing system allows for wide use in clinical laboratories for robust tracking of both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) infections to help focus resources effectively, assess the possibility of an outbreak or transmission event, and inform infection prevention and control. CC8 strains of S. aureus are prevalent pathogens in the United States causing infection in both immunocompromised and healthy ...
"Staphylococcal Infections". MedlinePlus [Internet]. Bethesda, MD: National Library of Medicine, USA. Skin infections are the ... Deeply penetrating S. aureus infections can be severe. Skin infections are the most common form of S. aureus infection. This ... Large pimples that appear in those areas may exacerbate the infection if lacerated. This can lead to staphylococcal scalded ... Each year, around 500,000 patients in hospitals of the United States contract a staphylococcal infection, chiefly by S. aureus ...
"Staphylococcal Infections". MedlinePlus [Internet]. Bethesda, MD: National Library of Medicine, USA. Skin infections are the ... or infection around the hair follicle, in women who wax or shave their bikini areas. Some of these infections can develop into ... Pubic hair grooming has been associated with injury and infection. It is estimated that about 1/4 groomers have had at least ... Pubic lice do not transmit disease; however, secondary bacterial infection can occur from scratching of the skin. They are much ...
"Staphylococcal Infections - Infectious Diseases". Merck Manuals Professional Edition. Retrieved 2020-10-06. Paul NC, Moodley A ... S. pseudintermedius infections in a human host have been known to cause endocarditis, post-surgical infections, inflammation of ... It is also one of the leading causes of bacterial skin and soft tissue infections, such as pyoderma, urinary tract infections, ... pseudintermedius vary between strains and do not determine if the bacteria will cause an infection. Rather, infection is a ...
"Staphylococcal Infections - Infectious Diseases". Merck Manuals Professional Edition. Retrieved 2020-10-18. Foster G, Barley J ... Most infections were also related to wound-infection (mainly surgical-site infections) - however, infection-related mortality ... S. intermedius is a common commensal of dogs and cats, though rarely causes infections in humans. However, infections have been ... Dogs are most commonly affected by this skin infection which may be caused by a bacterial infection or sometimes, but less ...
He developed cirrhosis and a staphylococcal infection. He was hospitalized at St. Vincent's Infirmary in Little Rock, Arkansas ...
Steele RW, Laner SA, Graves MH (February 1980). "Recurrent staphylococcal infection in families". Arch Dermatol. 116 (2): 189- ... A boil, also called a furuncle, is a deep folliculitis, infection of the hair follicle. It is most commonly caused by infection ... "Staph Infection Causes, Symptoms, Treatment - Staph Infection Diagnosis". eMedicineHealth. Tamir J, Haik J, Schwartz E (2003 ... causing infections (wound infections, abscesses, osteomyelitis, endocarditis, pneumonia) that may severely harm or kill the ...
Staphylococcal food poisoning Staphylococcus species Staphylococcal infection Staphylococcus species Strongyloidiasis ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
... for example chronic staphylococcal infections. For animals, conventional mass-produced vaccines are less effective as they ... including skin infections, respiratory tract infections, colon infections and urinary tract infections. Autogenous vaccines ... Autovaccines in Individual Therapy of Staphylococcal Infections". In Savini V (ed.). Pet-To-Man Travelling Staphylococci. ... which are all caused by staphylococci infections. For pigs, autogenous vaccines can be used for skin infections; while for cows ...
... novel antibiotics for staphylococcal infections". Antimicrobial Agents and Chemotherapy. 47 (6): 2051-5. doi:10.1128/AAC.47.6. ...
Bigger JW (14 October 1944). "Treatment of staphylococcal infections with penicllin by intermittent sterilization". Lancet. 244 ... Examples are chronic infections of implanted medical devices such as catheters and artificial joints, urinary tract infections ... Fungal persister cells are a common cause of recurring infections due to Candida albicans a common biofilm infection of ... Such non-growing bacteria have been observed to persist during infections from Salmonella. Persister cells are the main cause ...
... is used to treat mild-to-moderate staphylococcal infections. To decrease the development of resistance, ... Specific approved indications include: Staphylococcal skin infections and cellulitis - including impetigo, otitis externa, ... It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria. It is active against beta- ... Dicloxacillin is used for the treatment of infections caused by susceptible bacteria. ...
Le Traitement des infections staphylococciques, 1906 - Treatment of staphylococcal infection. Traité de thérapeutique ...
CS1 maint: discouraged parameter (link) Barber, Mary (1947-11-29). "Staphylococcal Infection due to Penicillin-Resistant ...
Barber, Mary (29 November 1947). "Staphylococcal Infection due to Penicillin-Resistant Strains". British Medical Journal. 2 ( ... Between 1948 and 1958, her focus shifted to cross-infection by Staphylococcus in hospitals, which she found to be caused by ...
Yellow creamy discharge is observed in staphylococcal infection; bloody opalescent discharge in streptococcal infection, while ... Other causes producing skin ulcers include bacterial or viral infections, fungal infections and cancers. Blood disorders and ... and infections that are usually seen in those who are immunocompromised, for example ecthyma gangraenosum. It is important to ...
Bigger JW (14 October 1944). "Treatment of staphylococcal infections with penicillin by intermittent sterilization". Lancet. ... Bigger JW (14 October 1944). "Treatment of staphylococcal infections with penicllin by intermittent sterilization". Lancet. 244 ... Examples are chronic infections of implanted medical devices such as catheters and artificial joints, urinary tract infections ... Indeed, it appears that persister cells are the main cause for relapsing and chronic infections. Chronic infections can affect ...
... complications from staphylococcal infection. Robert H. Rines, 87, American scientist, inventor, composer and Loch Ness Monster ... Alice McGrath, 92, American activist (Sleepy Lagoon murder trial), infection from a chronic illness. Sir Anthony Mullens, 73, ... Arabic) Robert Holdstock, 61, British science fiction author, Escherichia coli infection. Solange Magnano, 38, Argentinian ...
John JF (October 2006). "Drug evaluation: tefibazumab--a monoclonal antibody against staphylococcal infection". Current Opinion ... Tefibazumab (named Aurexis but not approved) is a humanized monoclonal antibody for the treatment of severe infections with ... "Registered and investigational drugs for the treatment of methicillin-resistant Staphylococcus aureus infection". Recent ...
This mainly involves Streptococcus pyogenes bacteria, alone or in combination with staphylococcal infections. Both types of ... other bacterial infections require two or more days to become symptomatic. Type II infection: This infection accounts for 20 to ... Type I infection: This is the most common type of infection, and accounts for 70 to 80% of cases. It is caused by a mixture of ... Type III infection: Vibrio vulnificus, a bacterium found in saltwater, is a rare cause of this infection, which occurs through ...
... some staphylococcal infections, and cholera. These vaccines were not only used throughout France, but were also sent worldwide ... When a small quantity of this is rubbed on the skin or eye, an infection occurs. Nicolle's work was not only influential in ... later switched to using guinea pigs as his model organism instead of chimpanzees as they were just as susceptible to infection ...
No association with occurrence of severe staphylococcal infection was found. Moreover, a recent study reported rs111200466, a ... These newly formed antibodies would arrive too late in an acute infection, however, so what we think of as "immunology" ... Borrello S, Nicolò C, Delogu G, Pandolfi F, Ria F (2011). "TLR2: a crossroads between infections and autoimmunity?". ... Lorenz E (2007). "TLR2 and TLR4 expression during bacterial infections". Current Pharmaceutical Design. 12 (32): 4185-93. doi: ...
Main article: Staphylococcal infection. Staphylococcus can cause a wide variety of diseases in humans and animals through ... Staph Infection in Nose.' *^ "Sialoadenitis: inflammation of the salivary glands". The Medical Consumer's Advocate. 2001-01-04 ... The taxonomy is based on 16s rRNA sequences,[7] and most of the staphylococcal species fall into 11 clusters: *S. aureus group ... It is rarely implicated in infections in humans, as a zoonosis. S. epidermidis, a coagulase-negative species, is a commensal of ...
... is indicated in the treatment of staphylococcal infections, except those caused by MRSA. U.S. clinical practice ... leads to a more serious super-infection with an organism like Clostridium difficile Abdominal pain Yeast infections (thrush) ... As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, in particular, ... guidelines recommend either nafcillin or oxacillin as the first-line treatment of choice for staphylococcal endocarditis in ...
He recovered but lost vision in his right eye due to a staphylococcal infection. Portions of M2-F2 footage including Peterson's ...
... is an antibiotic, obtained from Amycolatopsis lurida, previously used to treat staphylococcal infections. It is no ...
Skin infections, in particular the widespread methicillin-resistant Staphylococcal aureus, remain swollen and red. Pus forms ... Some spider bites do leave a large enough wound that infection may be a concern. However, it is generally the toxicity of ... Other skin lesions and infections are much more common than spider bites. Physicians have reported brown recluse spider bites ...
... infections causing gastroenteritis are the second most common infection (after the common cold), and they result in between 200 ... Lin, Z; Kotler, DP; Schlievert, PM; Sordillo, EM (May 2010). "Staphylococcal enterocolitis: forgotten but not gone?". Digestive ... "Infection and Drug Resistance. 6: 133-61. doi:10.2147/IDR.S12718. PMC 3815002 . PMID 24194646.. ... This infection is usually transmitted by contaminated water or food.[30] Toxigenic Clostridium difficile is an important cause ...
... is also seen in staphylococcal and corynebacterial mixed infections in bulls.[25] ... Immunosuppressive drugs, and other illnesses or infections that weaken the immune system, are also factors that make infection ... focus on skin and soft-tissue infections". Clinical Microbiology and Infection. 21: S27-S32. doi:10.1016/j.cmi.2015.03.024. ... more serious infections such as an underlying bone infection or necrotizing fasciitis should be ruled out.[3] ...
"RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection". Antimicrobial ... Immunoglobulins are antibodies expressed and secreted by hosts in response to an infection. These immunoglobulins play a major ... and human herpesviruses depend on a subset of genes that allow them to maintain a chronic infection by reactivating when ... and effective vaccines or toxoids may be eventually produced to treat and prevent infection. There are three general ...
It has a high clinical and bacteriological rate of success in staphylococcal and streptococcal infections. Cephaloridine is ... Today, it is more commonly used in veterinary practice to treat mild to severe bacterial infections caused by penicillin ... Before the 1970s, cephaloridine was used to treat patients with urinary tract infections. Besides the drugs has been used ... "Absence of nephrotoxicity during cephaloridine therapy for urinary-tract infection". Lancet. 2 (7776): 514-6. doi:10.1016/S0140 ...
Infection[edit]. Main article: Pneumococcal infection. S. pneumoniae is part of the normal upper respiratory tract flora. As ... Historically, Haemophilus influenzae has been a significant cause of infection, and both H. influenzae and S. pneumoniae can be ... S. pneumoniae infection stimulates polymorphonuclear leukocytes (granulocytes) to produce an oxidative burst that is ... Sepsis is caused by overwhelming response to an infection and leads to tissue damage, organ failure, and even death. The ...
It is characterized by recurrent "cold" staphylococcal infections (due to impaired recruitment of neutrophils),[2] unusual ... Most patients with hyper IgE syndrome are treated with long-term antibiotic therapy to prevent staphylococcal infections. Good ... HIES often appears early in life with recurrent staphylococcal and candidal infections, pneumonias, and eczematoid skin. ... Recurrent, "cold", staphylococcal abscesses". Lancet. 1 (7445): 1013-5. doi:10.1016/S0140-6736(66)90119-X. PMID 4161105.. ...
The mainstay of treatment for SSSS is supportive care along with eradication of the primary infection. Conservative measures ... Staphylococcal scalded skin syndrome (SSSS) is a dermatological condition caused by Staphylococcus aureus. ... Mockenhaupt M, Idzko M, Grosber M, Schöpf E, Norgauer J (April 2005). "Epidemiology of staphylococcal scalded skin syndrome in ... caused by staphylococcal exotoxin after Keith Powell proposed equating it with the condition currently known as staphylococcal ...
Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[12] ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract.[1] When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ... Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination ...
Bacterial infection is the most common cause.[8] Often many different types of bacteria are involved in a single infection.[6] ... They are usually caused by a bacterial infection.[8] Often many different types of bacteria are involved in a single infection. ... Marx, John A. Marx (2014). "Skin and Soft Tissue Infections". Rosen's emergency medicine : concepts and clinical practice (8th ... Abscesses are caused by bacterial infection, parasites, or foreign substances. ...
... of people with gonorrheal infection also have chlamydial infection.[54] Infections of the throat can be especially problematic ... Both men and women with infections of the throat may experience a sore throat, though such infection does not produce symptoms ... The infection is usually spread from one person to another through vaginal, oral, or anal sex.[15][22] Men have a 20% risk of ... "Gonococcal Infections - 2015 STD Treatment Guidelines". 4 January 2018.. *^ Ryan, KJ; Ray, CG, eds. (2004). Sherris Medical ...
A49.) Bacterial infection of unspecified site *(A49.0) Staphylococcal infection, unspecified ... A31.) Infection due to other mycobacteria *(A31.0) Pulmonary mycobacterial infection *Infection due to Mycobacterium avium ... A80-B34 - Viral infections[संपादित करें]. (A80-A89) Viral infections of the central nervous system[संपादित करें]. *(A80.) Acute ... B34.) Viral infection of unspecified site. B35-B89 - Infections caused by fungi, protozoans, worms, and infestations[संपादित ...
The presence of a carbuncle is a sign that the immune system is active and fighting the infection.[2] The infection is ... persons with diabetes and immune system diseases are more likely to develop infections (especially bacterial infections of the ... A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus aureus or Streptococcus ... Ni Riain, Una (2008-12-01). "Guide to the management of bacterial skin infections". Prescriber. 19 (23-24): 28-37. doi:10.1002/ ...
As an example, several staphylococcal species remain harmless on the skin, but, when present in a normally sterile space, such ... Primary infection versus secondary infection. A primary infection is infection that is, or can practically be viewed as, the ... An infection that is inactive or dormant is called a latent infection.[10] An example of a latent bacterial infection is latent ... Viral infection Bacterial infection Typical symptoms In general, viral infections are systemic. This means they involve many ...
No association with occurrence of severe staphylococcal infection was found.[20] ... Lorenz E (2007). "TLR2 and TLR4 expression during bacterial infections". Current Pharmaceutical Design. 12 (32): 4185-93. doi: ... These newly formed antibodies would arrive too late in an acute infection, however, so what we think of as "immunology" ... Borrello S, Nicolò C, Delogu G, Pandolfi F, Ria F (2011). "TLR2: a crossroads between infections and autoimmunity?". ...
Mandell, Gerald L.; Bennett, John E.; Dolin, Raphael (2004). Mandell's Principles and Practices of Infection Diseases (6th ... Lin, Z; Kotler, DP; Schlievert, PM; Sordillo, EM (2010 May). "Staphylococcal enterocolitis: forgotten but not gone?". Digestive ... Leonard, J; Marshall, JK, Moayyedi, P (2007 Sep). "Systematic review of the risk of enteric infection in patients taking acid ... Meloni, A; Locci, D, Frau, G, Masia, G, Nurchi, AM, Coppola, RC (2011 Oct). "Epidemiology and prevention of rotavirus infection ...
Ophthalmological conditions: blepharitis is an infection of the eyelid. Anterior blepharitis is either staphylococcal ... Infections: There are many bodily infections that can cause the loss of eyelashes/eyebrows. The most common infection may be ... Infections like syphilis by causing a moth-eaten appearance of the eyebrow hair loss. Viral infections like herpes or HIV can ... Syphilis or other viral infections like herpes or HIV can cause the loss of eye hair as well. Fungal infections, like ...
"Pathogenesis of intestinal and systemic rotavirus infection". Journal of Virology. 78 (19): 10213-10220. doi:10.1128/JVI.78.19 ... Staphylococcal enteritis. ReferencesEdit. *^ a b Dugdale, David C., IIII, and George F Longretch "Enteritis". MedlinePlus ...
Role during infection[edit]. Hemolysins are thought to be responsible for many events in host cells. For example, iron may be a ... It produces a ring-shaped complex called a staphylococcal alpha-hemolysin pore. In nature, Staphylococcus aureus secretes alpha ... S.aureus is a dangerous pathogen that may lead cells to necrotizing infections usually recognized by a massive inflammatory ... Alpha-hemolysin from uropathogenic E. coli produces extra-intestinal infections and can cause cystitis, pyelonephritis, and ...
Infection can be prevented by immunization with the tetanus vaccine.[1] In those who have a significant wound and less than ... Tetanus is caused by an infection with the bacterium Clostridium tetani,[1] which is commonly found in soil, saliva, dust, and ... Tetanus, also known as lockjaw, is an infection characterized by muscle spasms.[1] In the most common type, the spasms begin in ... In order to survive a tetanus infection, the maintenance of an airway and proper nutrition are required. An intake of 3,500 to ...
Intoxication can occur naturally as a result of either wound or intestinal infection or by ingesting preformed toxin in food. ... For wound infections, infected material may be removed surgically.[47] Botulinum antitoxin is available and may be used to ... Infection with the bacterium causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes ...
They may protect against or fail to protect (if down-regulated by an infection) against cancers.[1] Mutations in HLA may be ... DR protein (DRA:DRB1*0101 gene products) with bound Staphylococcal enterotoxin ligand (subunit I-C), view is top down showing ...
Urinary tract infection. *Enterococcus faecium. Bacillales. (Cat+). Staphylococcus. Cg+. *S. aureus *Staphylococcal scalded ...
Janknegt R (June 1997). "The treatment of staphylococcal infections with special reference to pharmacokinetic, pharmacodynamic ... Treatment of MRSA infection is urgent and delays can be fatal.[19]:328 The location and history related to the infection ... Other infections[edit]. Treatment is not standardized for other instances of MRSA infection in a wide range of tissues. ... Most of these infections were HA-MRSA. MRSA accounts for 26% of lung infections in those with cystic fibrosis.[103] ...
This works against staphylococcal and streptococcal infections. Pseudomonas aeruginosa also produces substances that inhibit ... Though usually not pathogenic, it can cause skin infections and even life-threatening illnesses in those that are ... if it gains entry into the circulatory system it can result in infections in bone, joint, gastrointestinal, and respiratory ... may inversely allow for aberrant yeast colonization and infection."[3] ...
To fight off a phage infection, the sequence of the CRISPR spacer must correspond perfectly to the sequence of the target phage ... replicated and finally packaged into small capsids by certain staphylococcal temperate phages. PICIs use several mechanisms to ... Another way for bacteria to defend against phage infection is by having chromosomal islands. A subtype of chromosomal islands ... Datsenko KA, Pougach K, Tikhonov A, Wanner BL, Severinov K, Semenova E (July 2012). "Molecular memory of prior infections ...
... s secreted by the root of their host plant help Rhizobia in the infection stage of their symbiotic relationship with ... "Inhibitory effects of various plant polyphenols on the toxicity of Staphylococcal alpha-toxin". Microbial Pathogenesis. 42 (5-6 ... or whether dietary flavonoid intake offers any protection against infection. Flavonoid synthesis in plants is induced by light ... research is needed to determine if flavonoids could be used as pharmaceutical drugs for the treatment of bacterial infection, ...
... (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection ... Infection control[edit]. Rigorous infection protocols are required to minimize this risk of transmission.[54] Infection control ... Clostridioides difficile infection. Other names. C. difficile associated diarrhea (CDAD), Clostridium difficile infection, C. ... Several treatment options exist for recurrent C difficile infection. For the first episode of recurrent C difficile infection, ...
A stool culture is used to detect the presence of disease-causing bacteria (pathogenic) and help diagnose an infection of the ... Finally, as most staphylococcal food poisoning are the result of food handling, hand washing is critical. Food handlers should ... Staphylococcal enteritis is an inflammation that is usually caused by eating or drinking substances contaminated with staph ... Staphylococcal enteritis may be avoided by using proper hygiene and sanitation with food preparation. This includes thoroughly ...
Parasitic infections through food. *Amoebiasis. *Anisakiasis. *Cryptosporidiosis. *Cyclosporiasis. *Diphyllobothriasis. * ...
Crayfish will typically maul the adult newts with their claws, and subsequent infection can lead to death. Taricha torosa that ...
Infection with the bacterium causes the disease botulism. The toxin is also used commercially in medicine, cosmetics and ... For wound infections, infected material may be removed surgically.[33] Botulinum antitoxin is available and may be used to ...
Learn how to prevent and treat Staph infections. ... Staph infections are caused by bacteria that are commonly found ... Skin infections, which are the most common types of staph infections. *Bacteremia, an infection of the bloodstream. This can ... The symptoms of a staph infection depend on the type of infection:. *Skin infections can look like pimples or boils. They may ... Staph Infections (Nemours Foundation) Also in Spanish * Staph Infections (Mayo Foundation for Medical Education and Research) ...
Definition Staphylococcal (staph) infections are communicable infections caused by staph organisms and often characterized by ... Staphylococcal infections. Definition. Staphylococcal (staph) infections are communicable infections caused by staph organisms ... Staphylococcal Infections Complete Human Diseases and Conditions COPYRIGHT 2008 Gale Group. Staphylococcal Infections. What Are ... Staphylococcal infections. Definition. Staphylococcal (staph) infections are communicable diseases caused by certain bacteria ...
Staphylococcal Infection: Antitoxic Immunity. Br Med J 1960; 1 doi: https://doi.org/10.1136/bmj.1.5175.743 (Published 12 March ...
The Problem of Staphylococcal Infection. Br Med J 1956; 2 doi: https://doi.org/10.1136/bmj.2.4997.837 (Published 13 October ...
Phenol-soluble modulins and staphylococcal infection.. Peschel A1, Otto M.. Author information. 1. Cellular and Molecular ... PSMs have multiple roles in staphylococcal pathogenesis, causing lysis of red and white blood cells, stimulating inflammatory ... Several α-type psm genes are not annotated in staphylococcal genomes owing to their short length. Note that the psmα and psmδ ... and suggest potential avenues to target PSMs for the development of anti-staphylococcal drugs. ...
Immunotherapeutic strategies to combat staphylococcal infections.. Ohlsen K1, Lorenz U.. Author information. 1. University of ... the search for alternative strategies to efficiently combat staphylococcal infections is urgently demanded to decrease the ... Antibiotic-resistant staphylococci are the leading cause of nosocomial infections in many hospitals around the world. Meanwhile ... Würzburg, Institute for Molecular Infection Biology, Josef-Schneider-Str. 2, Bau D15, 97080 Würzburg, Germany. [email protected] ...
1984)‎. SURVEILLANCE OF STAPHYLOCOCCAL INFECTIONS = SURVEILLANCE DES STAPHYLOCOCCIES. Weekly Epidemiological Record = Relevé ...
However, the incidence of infections due to Staphylococcus epidermidis and other coagulase-negative staphylococci has been ... Staphylococcal infections are usually caused by the organism Staphylococcus aureus. ... encoded search term (Staphylococcal Infections) and Staphylococcal Infections What to Read Next on Medscape ... Staphylococcal Infections Workup. Updated: Jun 12, 2019 * Author: Thomas E Herchline, MD; Chief Editor: Mark R Wallace, MD, ...
Preventing Staphylococcal (Staph) Infection. The safety and scientific validity of this study is the responsibility of the ... Patients with a history of documented infection with Staphylococcus aureus cared for at Veterans Affairs Ann Arbor Healthcare ... Patients who completed 18 months of mupirocin or developed new (recurrent) S. aureus infection.. ... Participants who completed 18 months of placebo or developed new (recurrent) S. aureus infection.. ...
T. O. Abbas, "Pelvic Primary Staphylococcal Infection Presenting as a Thigh Abscess," Case Reports in Surgery, vol. 2013, ... Pelvic Primary Staphylococcal Infection Presenting as a Thigh Abscess. T. O. Abbas ...
... Reyhan Amode, Paul Bilan, Carole Sin, Anaïs Marchal, ... We report here a case of puffy hand syndrome revealed by a severe staphylococcal infection with toxic complications mimicking a ... So, we concluded it as a puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement. The ... We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking ...
Relationship of Staphylococcal Colonization to Infection. The safety and scientific validity of this study is the ... Percent of infection strains which were also colonizer earlier [ Time Frame: 3 years ]. ... Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year. ...
A staphylococcal infection or staph infection is an infection caused by members of the Staphylococcus genus of bacteria. These ... Any S. aureus infection can cause the staphylococcal scalded skin syndrome, a cutaneous reaction to exotoxin absorbed into the ... Other staphylococcal species have been implicated in human infections, notably S. lugdunensis, S. schleiferi, and S. caprae. ... Staph infection is typically characterized by redness, pus, swelling, and tenderness in areas of the infection. But, each type ...
... aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies ... to prevent and treat staphylococcal infections especially in patients who are at high risk.The pathogenicity of staphylococci ... is emerging as an important agent of nosocomial infections, particularly in association with indwelling medical devices.The ... osteomyelitis and post-operative infections. Among staphylococci, Staphylococcus aureus is regarded as the most virulent ...
Expanding on the theme that some strains specialize in certain types of infection, Anderson et al. (2012) describe an ex vivo ... Citation: McGavin MJ and Heinrichs DE (2012) The staphylococci and staphylococcal pathogenesis. Front. Cell. Inf. Microbio. 2: ... Sheldon, J. R., and Heinrichs, D. E. (2012). The iron-regulated staphylococcal lipoproteins. Front. Cell. Infect. Microbiol. 2: ... 2012) shows that major clonal types of S. aureus known for causing hospital and community acquired infections, exhibit distinct ...
Staphylococcal scalded skin syndrome is a clinical term used for a spectrum of primarily neonatal blistering skin disorders ... A case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome is described. ... Neonatal Pseudomonas putida infection presenting as staphylococcal scalded skin syndrome Eur J Clin Microbiol Infect Dis. 1998 ... A case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome is described. Staphylococcal ...
Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, ... All consecutive patients with a staphylococcal PJI infection of the hip, knee or shoulder prosthesis will be included, if no ... More From BioPortfolio on "Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection". *Related ... Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection. 2014-07-23 21:08:46 , BioPortfolio ...
Multiplex PCR Protocol for the Diagnosis of Staphylococcal Infection. William J. Mason, Jon S. Blevins, Karen Beenken, Noroyono ... Multiplex PCR Protocol for the Diagnosis of Staphylococcal Infection. William J. Mason, Jon S. Blevins, Karen Beenken, Noroyono ... Multiplex PCR Protocol for the Diagnosis of Staphylococcal Infection. William J. Mason, Jon S. Blevins, Karen Beenken, Noroyono ... Multiplex PCR Protocol for the Diagnosis of Staphylococcal Infection Message Subject (Your Name) has forwarded a page to you ...
Difficult-to-Treat Staphylococcal Infections in Men Who Have Sex with Men Annals of Internal Medicine; 148 (4): I-42 ... During the last decade staphylococcal infections have become a problem of increasing concern. Most of the acute bacterial ... Solid-Phase Radioimmunoassay for Immunoglobulin G Staphylococcus aureus Antibody in Serious Staphylococcal Infection Annals of ... It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials ...
Browse by Outcome: Staphylococcal Infections (4 articles). % of records by year: 1965 2017 ...
The autopsy revealed a severe disseminated staphylococcal disease and confirmed dengue infection. ... several reports warn about the potential occurrence of severe infections and even death. The clinical spectrum of dengue is ... who subsequently died of acute multi-organic failure related to Staphylococcus aureus infection. ... f Fatal Staphylococcal Infection following Classic Dengue Fever * Authors: Stanley Almeida Araújo, Daniel Ribeiro Moreira, ...
... in Staphylococcus epidermidisisolated from prosthetic joint infections (PJIs) and, if possible,... ... The aim of the present study was to characterise the staphylococcal cassette chromosome mec (SCC mec) ... Prosthetic Joint Infection mecA Gene SCCmec Type Antibiotic Susceptibility Pattern Staphylococcal Species These keywords were ... Meticillin resistance in orthopaedic coagulase-negative staphylococcal infections. J Hosp Infect 79(3):248-253PubMedCrossRef ...
Reports on the results of a study using quinupristin/dalfopristin IV to treat patients with staphylococcal skin infections ... Outlines a number of guidelines for the prevention and control of staphylococcal infections in correlation with reduced ... Interim guidelines for prevention and control of staphylococcal infection associated with... // MMWR: Morbidity & Mortality ... Home » Vancomycin for Staphylococcal Shunt Site Infections in Patients on Regular Haemodialysis ...
... have developed a new method that may allow for rapid simultaneous detection of staphylococcal and botulinum toxins in food. ... Staphylococcal enterotoxin B (SEB) and botulinum toxin A (BotA) are common causes of food poisoning in humans and pose high ... Researchers from Washington, D.C. have developed a new method that may allow for rapid simultaneous detection of staphylococcal ... Researchers from Washington, D.C. have developed a new method that may allow for rapid simultaneous detection of staphylococcal ...
Murine macrophage activation by staphylococcal exotoxins.. S D Fleming, J J Iandolo, S K Chapes ... Staphylococcal enterotoxin A, toxic shock syndrome toxin 1, and both exfoliative toxins triggered C3HeB/FeJ macrophages to ... Murine macrophage activation by staphylococcal exotoxins. Message Subject (Your Name) has forwarded a page to you from ... Thank you for sharing this Infection and Immunity article.. NOTE: We request your email address only to inform the recipient ...
Staphylococcal infections were associated with longer hospital stays and higher risk for death relative to all-cause ... Hospitalized children with staphylococcal infections were identified through the California Office of Statewide Health Planning ... Infections were categorized as community onset, community onset health care-associated, or hospital onset. Infection incidence ... The number of methicillin-resistant Staphylococcus aureus infections increased, and the number of methicillin-susceptible S. ...
Staphylococcal Infections. James K. Todd. Pediatrics in Review December 2005, 26 (12) 444-450; DOI: https://doi.org/10.1542/pir ... S aureus is the most common cause of pyogenic infection of the skin; it also may cause osteomyelitis, septic arthritis, wound ... staphylococcal scarlet fever, scalded skin syndrome, and toxic shock syndrome (TSS). Coagulase-negative staphylococci tend to ... infection, abscess, pneumonia, empyema, endocarditis, pericarditis, meningitis, and toxin-mediated diseases, including food ...
International Symposium on Staphylococci and Staphylococcal Infections Nine Tree Convention Center Seoul South Korea August 30 ... International Symposium on Staphylococci and Staphylococcal Infections Event Date: 08/30/2016 (All day) to 09/02/2016 (All day) ...
Because the occurrence of fully vancomycin-resistant staphylococcal infection in a hospital could result in serious public ... Interim Guidelines for Prevention and Control of Staphylococcal Infection Associated with Reduced Susceptibility to Vancomycin ... HOSPITAL INFECTIONS PROGRAM State/Fed Gov: For free copies. write to: CDC, MMWR MS(C-08). Atlanta, GA 30333 This page last ... Hospital Infections Program, National Center for Infectious Diseases, CDC. References. References * Garrett DO, Jochimsen E, ...
Effect of protein A on staphylococcal opsonization. Message Subject (Your Name) has forwarded a page to you from Infection and ... Effect of protein A on staphylococcal opsonization.. P K Peterson, J Verhoef, L D Sabath, P G Quie ... Thank you for sharing this Infection and Immunity article.. NOTE: We request your email address only to inform the recipient ... Your Name) thought you would be interested in this article in Infection and Immunity. ...
  • A type called Staphylococcus aureus causes most infections. (medlineplus.gov)
  • Some staph infections, such as MRSA (methicillin-resistant Staphylococcus aureus), are resistant to many antibiotics . (medlineplus.gov)
  • Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. (medscape.com)
  • The Association between Staphylococcus aureus strains carrying panton-valentine leukocidin genes and the development of deep-seated follicular infection. (medscape.com)
  • Patients with a history of documented infection with Staphylococcus aureus cared for at Veterans Affairs Ann Arbor Healthcare System, University of Michigan Medical Center, St. Joseph Mercy Hospital (Ypsilanti, MI), and Pittsburgh VA Medical Center from April 2005-August 2012. (clinicaltrials.gov)
  • A staphylococcal infection or staph infection is an infection caused by members of the Staphylococcus genus of bacteria. (wikipedia.org)
  • Problematically, methicillin-resistant Staphylococcus aureus (MRSA) has become a major cause of hospital-acquired infections. (wikipedia.org)
  • S. epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters. (wikipedia.org)
  • Among staphylococci, Staphylococcus aureus is regarded as the most virulent species, while S. epidermidis, once considered harmless, is emerging as an important agent of nosocomial infections, particularly in association with indwelling medical devices. (frontiersin.org)
  • Staphylococcal scalded skin syndrome is a clinical term used for a spectrum of primarily neonatal blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus. (nih.gov)
  • Studies have suggested the reduced effectiveness of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections with high vancomycin minimum inhibitory concentrations. (bioportfolio.com)
  • That is particularly true of Staphylococcus epidermidis , which is a frequent cause of infections associated with indwelling medical devices ( 1 , 6 ) However, the prevalence of S. epidermidis as a commensal bacterium has the adverse diagnostic consequence of false-positive culture results owing to contamination of the specimen during collection ( 35 ). (asm.org)
  • In this study, we show the clinical and anatomopathological data of a patient infected with dengue, who subsequently died of acute multi-organic failure related to Staphylococcus aureus infection. (ajtmh.org)
  • The aim of the present study was to characterise the staphylococcal cassette chromosome mec (SCC mec ) in Staphylococcus epidermidis isolated from prosthetic joint infections (PJIs) and, if possible, assign them to any of the presently known SCC mec types. (springer.com)
  • Vuong C, Otto M (2002) Staphylococcus epidermidis infections. (springer.com)
  • Hellmark B, Unemo M, Nilsdotter-Augustinsson A, Söderquist B (2009) Antibiotic susceptibility among Staphylococcus epidermidis isolated from prosthetic joint infections with special focus on rifampicin and variability of the rpoB gene. (springer.com)
  • Ito T, Katayama Y, Asada K, Mori N, Tsutsumimoto K, Tiensasitorn C, Hiramatsu K (2001) Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus . (springer.com)
  • Berglund C, Söderquist B (2008) The origin of a methicillin-resistant Staphylococcus aureus isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus and Staphylococcus aureus . (springer.com)
  • Hanssen AM, Sollid JU (2007) Multiple staphylococcal cassette chromosomes and allelic variants of cassette chromosome recombinases in Staphylococcus aureus and coagulase-negative staphylococci from Norway. (springer.com)
  • Reports on the results of a study using quinupristin/dalfopristin IV to treat patients with staphylococcal skin infections caused by Staphylococcus aureus. (ebscohost.com)
  • The number of methicillin-resistant Staphylococcus aureus infections increased, and the number of methicillin-susceptible S. aureus infections remained unchanged. (cdc.gov)
  • Describe the major clinical syndromes of Staphylococcus aureus infection. (aappublications.org)
  • Our laboratory has developed a murine model of polymicrobial intra-abdominal infection with Candida albicans and Staphylococcus aureus , demonstrating that polymicrobial infections cause high levels of mortality, while monoinfections do not. (mdpi.com)
  • Staphylococcus aureus  is a virulent pathogen that is responsible for a wide range of superficial and invasive infections. (peptide.com)
  • Both Staphylococcus epidermidis and Staphylococcus aureus are important causes of infections associated with catheters and other medical devices. (asm.org)
  • In recent years, however, S. epidermidis emerged, together with Staphylococcus aureus , as a frequent etiologic agent of infections associated with catheters and other indwelling medical devices. (asm.org)
  • Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection (PJI). (physiciansweekly.com)
  • In this retrospective cohort study, patients were included who received clindamycin-rifampin combination therapy to treat a periprosthetic hip or knee infection by Staphylococcus aureus or coagulase-negative staphylococci. (biomedcentral.com)
  • Staphylococcus is a form of bacteria that can cause a wide range of infections, some of which can pose a serious risk to the health of an affected individual. (hernia-patchlawsuit.com)
  • The majority of infections resulting from hernia repair are caused by the staphylococcus bacteria. (hernia-patchlawsuit.com)
  • Staphylococcus epidermidis ( S. epidermidis ) has emerged as one of the leading pathogens of biomaterial-related infections. (utu.fi)
  • Panton-valentine leukocidin (PVL) is a pore-forming cytotoxin produced by some clones of Staphylococcus aureus that is associated with infections ranging from uncomplicated skin and soft tissue infections to life-threatening necrotizing pneumonia. (gla.ac.uk)
  • Staphylococcus infection is caused by staph or staphylococcus bacteria. (advancemarketanalytics.com)
  • In April 2017, XBiotech Inc. announced top-line results from its double-blind, placebo-controlled, phase I-II study evaluating the safety and efficacy of its FDA Fast Tracked true human antibody (514G3) for the treatment of Staphylococcus aureus bloodstream infections. (advancemarketanalytics.com)
  • Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility. (monashhealth.org)
  • Staphylococcus aureus , the most virulent of the many staphylococcal species, has demonstrated its versatility by remaining a major cause of morbidity and mortality despite the availability of numerous effective antistaphylococcal antibiotics. (mhmedical.com)
  • Infections with bacteria of the genus STAPHYLOCOCCUS. (sickkids.ca)
  • Most staphylococcal infections are easily treated with antibiotics, although methicillin-resistant Staphylococcus aureus (MRSA) is of growing concern in hospitals and the community. (vic.gov.au)
  • Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in humans and animals, as well as the cause of mastitis in dairy cattle. (biomedcentral.com)
  • Presence of fibrinogen-binding adhesin gene in Staphylococcus epidermidis isolates from central venous catheters-associated and orthopaedic implant-associated infections. (microbiologyresearch.org)
  • The bacterium Staphylococcus causes a group of infections, from minor skin and soft tissue infections to invasive infections called Staphylococcal infections or staph infections. (news-medical.net)
  • Among the many varieties of Staphylococci, the bacterium Staphylococcus aureus consists of methicillin-resistant Staphylococcus aureus (MRSA), which resists antibiotics such as flucloxacillin, commonly used for staph infections. (news-medical.net)
  • Staphylococcus aureus, the cause of most infections has PVL-Staphylococcus aureus, which generate Panton-Valentine leukocidin (PVL), a toxin that kills white blood cells resulting in recurring skin infections. (news-medical.net)
  • Staphylococcus (staph) is a type of bacteria that can cause many types of infections on and in your body. (rxlist.com)
  • More than 30 subspecies of Staphylococcus bacteria cause infections. (rxlist.com)
  • The most common type of Staph infection is caused by Staphylococcus aureus . (rxlist.com)
  • Staphylococcus can cause many different types of infections in and on around your body. (rxlist.com)
  • Staphylococcus infections usually appear on your skin's surface. (rxlist.com)
  • During the past several years, infections with methicillin-resistant Staphylococcus aureus strains (MRSA) have become increasingly prevalent in the US and worldwide. (grantome.com)
  • Staphylococcal infections are a group of infections caused by the bacterium Staphylococcus. (your.md)
  • There are many types of staphylococci, but most infections are caused by Staphylococcus aureus (S. aureus). (your.md)
  • Staphylococcus is a group of bacteria that can cause diseases as a result of infections of various tissues of the body. (soundhealthdoctor.com)
  • No vaccine is known to have the ability to prevent staphylococcus and the prevention of staph infections mainly requires paying attention to the risk factors that may increase the likelihood of getting a particular type of staph infection. (soundhealthdoctor.com)
  • Staphylococcus aureus remains a common cause of nosocomial bacterial infections and are often antibiotic resistant. (jimmunol.org)
  • Within 24 h of pulmonary staphylococcal infection, alveolar macrophages and other inflammatory cells are recruited to the mucosal site and may efficiently control the infection via various mechanisms including intracellular killing of macrophages and antimicrobial peptides contained in granules of granulocytes ( 4 , 5 , 7 , 8 ), suggesting a role for these innate cells in anti-staphylococcus host defense. (jimmunol.org)
  • Staphylococcal enterotoxin B (SEB) is an exotoxin excreted by the Staphylococcus aureus bacterium. (medscape.com)
  • Staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), have become a major public health problem. (cdc.gov)
  • Compared with children hospitalized with other health care conditions, children hospitalized with Staphylococcus aureus infections remained in the hospital longer and were at higher risk for death. (cdc.gov)
  • Other Staphylococcus species, collectively termed coagulase-negative staphylococci (CNS), are responsible for a variety of opportunistic infections in humans and animals [ 11 ]. (intechopen.com)
  • The staphylococcal scalded skin syndrome is an acute exfoliation of the skin caused by exfoliative toxins A and B. Although Staphylococcus aureus is a common cause of burn wound infection, SSSS following burn wound infection is rare. (utmb.edu)
  • Pseudomonas aeruginosa and Staphylococcus aureus are bacteria pathogens that cause a myriad of infections affecting various sites in the body including the eyes, ears, lungs, skin, heart, bones, and blood amongst others. (kingston.ac.uk)
  • Staphylococcus aureus is among the most common causes of health care-associated infections and accounts for significant morbidity and mortality. (medscape.com)
  • Skin infections such as boils and impetigo are caused by a staph bacteria called Staphylococcus aureus (S. aureus) and may be more challenging to treat. (medicalnewstoday.com)
  • Using whole-genome sequencing, we have further characterized three phenotypically different Staphylococcus capitis isolated from one prosthetic joint infection, highlighting the challenges in defining microbiological criteria for low-virulence prosthetic joint infections. (jbji.net)
  • In 1881, Sir Alexander Ogston, a Scottish surgeon, discovered that Staphylococcus can cause wound infections after noticing groups of bacteria in pus from a surgical abscess during a procedure he was performing. (wikipedia.org)
  • Some people carry staph bacteria on their skin or in their noses, but they do not get an infection. (medlineplus.gov)
  • But if they get a cut or wound, the bacteria can enter the body and cause an infection. (medlineplus.gov)
  • A localized staph infection is confined to a ring of dead and dying white blood cells and bacteria. (encyclopedia.com)
  • A person with staph infection is contagious until the bacteria is completely out of their body, and any wounds from the infection are healed. (wikipedia.org)
  • Infection after surgery - Hospitals are a very common place for staph bacteria to contaminate. (wikipedia.org)
  • But, each type of skin infection caused by staph bacteria is different. (wikipedia.org)
  • A few common skin infections caused by staph bacteria are: Boils - Boils are the most common type of staph infection, they are pockets of white pus that start where a hair follicle or oil gland is. (wikipedia.org)
  • Vaccines aimed at preventing S. aureus infection in bovine mastitis have been studied for many years, but have so far been unsuccessful due to the complexity of the bacteria, and the lack of suitable vaccine delivery vehicles. (biomedcentral.com)
  • About 15-40 per cent of healthy humans are carriers of S. aureus, that is, they have the bacteria on their skin without any active infection or disease (colonisation). (bestonlinemd.com)
  • Staphylococcal aureus bacteria are classified as Gram-positive cocci based on their appearance under a microscope. (bestonlinemd.com)
  • In staphylococcal intoxications there may be no viable bacteria to culture and the diagnosis may be made retrospectively on the basis of a blood test demonstrating an immune response (seroconversion) to toxins following a compatible illness. (bestonlinemd.com)
  • An easy remedy for nasal infections than can completely eradicate the presence of the bacteria in less than 7 days. (aspeneducationgroup.com)
  • If S. aureus bacteria infect your body, either through a wound on your skin or through your airways, they can cause serious infections. (rxlist.com)
  • Breastfeeding women can get a staph infection of the breast called mastitis, which can release bacteria into a mother's milk. (rxlist.com)
  • Skin infections with staph bacteria can cause a serious condition called scalded skin syndrome. (rxlist.com)
  • Frequent consequences are long-lasting and recurrent infections during which the bacteria constantly refine its properties and adapt to the host. (idw-online.de)
  • Following lung infection with PVL+ Staph (USA300), hC5aR-KI mice fail to clear the bacteria as efficiently as wild type animals, and their bronchoalveolar lavage fluid contains significantly elevated inflammatory cells. (grantome.com)
  • Staph infections are caused when bacteria get into a break or cut in the skin. (your.md)
  • Staphylococcal enterotoxin B (SEB) is 1 of 7 originally identified enterotoxins produced by certain strains of the coagulase-positive S aureus bacteria, a gram-positive cocci that form clumps. (medscape.com)
  • The purpose of this study is to show whether Veronate, a donor-selected staphylococcal human immune globulin intravenous (IGIV), can prevent an infection in the blood caused by staphylococcal bacteria in premature babies weighing between 500 and 1250 grams at birth. (clinicaltrials.gov)
  • Biofilm products actively suppress proinflammatory microbicidal responses,asevident bymacrophagepolarizationtoward ananti-inflammatory phenotype and the recruitment of myeloid-derived suppressor cells.With the rise in prosthetic hip and knee arthroplasty procedures, together with the recalcitrance of biofilm infections to antibiotic therapy, it is imperative to better understand themechanism of crosstalk between biofilm-associated bacteria and host immune cells. (nebraska.edu)
  • Penicillin V oral tablet is used to treat certain infections caused by bacteria. (healthline.com)
  • This kills off the bacteria that are causing your infection. (healthline.com)
  • Moreover, in the case of human medicine, the costs associated with the treatment of infections caused by antimicrobial-resistant bacteria represent a serious public health burden in hospital and community settings [ 10 ]. (intechopen.com)
  • These bacteria can be disseminated via the blood to other parts of the body away from the primary site of infection and consequences vary from mild to severe with death occurring in certain instances. (kingston.ac.uk)
  • P. aeruginosa and S. aureus exhibit multidrug resistance against current antibiotic treatment regimens, which accentuates the challenge in managing the infections caused by these bacteria. (kingston.ac.uk)
  • The most common cause of epiglottitis is infection with the bacteria called Haemophilus influenzae type b. (encyclopedia.com)
  • Popping pimples can cause an infection because bacteria can enter the wound, or it can rupture the pustule inside the skin. (medicalnewstoday.com)
  • In current diagnostic criteria for implant-associated bone- and joint infections, phenotypically identical low-virulence bacteria in two intraoperative cultures are usually required. (jbji.net)
  • Staphylococci are among the most important human pathogens and a major cause of morbidity and mortality worldwide, causing septicaemia, pneumonia, endocarditis, osteomyelitis and post-operative infections. (frontiersin.org)
  • This pathogen is an important cause of skin and skin and soft tissue infection (SSTI), pneumonia, and bloodstream infections. (cancertherapyadvisor.com)
  • Staphylococcal pneumonia in infancy. (asmscience.org)
  • These isolates are associated with infections that range from uncomplicated skin and soft tissue infections to life-threatening entities such as necrotizing pneumonia. (gla.ac.uk)
  • While virtually all staphylococcal strains carry ?HL, the PVL is increasingly associated with severe necrotizing pneumonia, with alarming susceptibility among non-immunocompromised individuals. (grantome.com)
  • Indeed, Staphylococcal pneumonia accounts for 20-30% of nosocomial infections and remains one of the leading causes of death during influenza epidemics ( 2 , 3 ). (jimmunol.org)
  • In this regard, a limited number of studies using murine models of pulmonary S. aureus infection have investigated microbial pathogenesis and host responses seen in pulmonary staphylococcal pneumonia ( 4 , 5 , 6 ). (jimmunol.org)
  • They are the leading cause of primary infections originating in hospitals (nosocomial infections) in the United States . (encyclopedia.com)
  • Antibiotic-resistant staphylococci are the leading cause of nosocomial infections in many hospitals around the world. (nih.gov)
  • Through regular cleansing of hands, healthcare workers (HCWs) reduce the risk to transmitting nosocomial pathogens between patients and thus reduce the risk of exogenously-acquired infection. (biomedcentral.com)
  • This organism is responsible for both nosocomial and community-based infections that range from relatively minor skin and soft tissue infections primarily to life-threatening systemic infections. (mhmedical.com)
  • Since the late 1970s, methicillin-resistant S. aureus (MRSA) strains have been identified in Victoria as a major cause of nosocomial infections and outbreaks. (vic.gov.au)
  • However, alcohol-based hand hygiene programs have been successfully associated with a reduction in the rates of nosocomial infections. (vic.gov.au)
  • Staphylococcal species are a leading cause of community- and nosocomial-acquired infections, where the placement of foreign materials increases infection risk. (nebraska.edu)
  • This perception is, however, changing as many species have emerged as important causes of nosocomial infections, particularly in relation to foreign-device-related infections and infections in immunocompromised patients [ 1 , 13 ]. (intechopen.com)
  • PSMs have multiple roles in staphylococcal pathogenesis, causing lysis of red and white blood cells, stimulating inflammatory responses and contributing to biofilm development and the dissemination of biofilm-associated infections. (nih.gov)
  • Here, we discuss recent progress made in our understanding of the biochemical and genetic properties of PSMs and their role in S. aureus pathogenesis, and suggest potential avenues to target PSMs for the development of anti-staphylococcal drugs. (nih.gov)
  • First, our knowledge of S. aureus pathogenesis in humans is rather preliminary and it is difficult to predict how animal data will equate to human infection. (frontiersin.org)
  • von Eiff C, Peters G, Heilmann C (2002) Pathogenesis of infections due to coagulase-negative staphylococci. (springer.com)
  • Biofilms are key to the pathogenesis of foreign body-associated infections, providing CoNS with a physical barrier to evade both host immune responses and systemic antimicrobial therapy. (mhmedical.com)
  • The Trobos Group is led by Associate Professor Margarita Trobos and has a research focus on biomaterial-associated infections, covering aspects on the pathogenesis (biofilm mechanisms and antimicrobial resistance) and evaluating novel diagnostic, preventive and therapeutic strategies. (gu.se)
  • Rare in adults and most common in newborns and other children under the age of five, scalded skin syndrome originates with a localized skin infection. (encyclopedia.com)
  • Several bullous lesions affected his hands and feet (Figure 1 ) without formal argument for a necrotizing fasciitis or a staphylococcal scalded skin syndrome. (hindawi.com)
  • Any S. aureus infection can cause the staphylococcal scalded skin syndrome, a cutaneous reaction to exotoxin absorbed into the bloodstream. (wikipedia.org)
  • A case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome is described. (nih.gov)
  • While Pseudomonas infections may present with vesico-bullous eruptions, this is believed to be the first case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome. (nih.gov)
  • Staphylococcal scalded skin syndrome (SSSS), which usually affects children less than five years old or rarely, adults with kidney failure. (bestonlinemd.com)
  • Skin infections can look like pimples or boils. (medlineplus.gov)
  • Skin infections are most common and usually cause symptoms such as boils or abscesses - painful, pus-filled lumps on the surface or just under the skin. (your.md)
  • Often, normal staph can result in minor epidermal infection like pimples or boils if the bacterium enters the epidermis through a sore or an open cut. (staphinfectionatoz.com)
  • The emergence of methicillin- and vancomycin- resistance among clinical isolates of S. aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies to prevent and treat staphylococcal infections especially in patients who are at high risk. (frontiersin.org)
  • The expected fragments were amplified from each of 60 staphylococcal isolates (13 oxacillin-resistant S. aureus isolates, 23 oxacillin-sensitive S. aureus isolates, 17 oxacillin-resistant CNS, and 7 oxacillin-sensitive CNS). (asm.org)
  • Based on the preceding discussion, the most important considerations with respect to the diagnosis of staphylococcal infections are (i) identification of staphylococci in clinical specimens, (ii) differentiation of S. aureus from the less-pathogenic CNS, and (iii) determination of whether isolates of either group are resistant to oxacillin. (asm.org)
  • Because the occurrence of fully vancomycin-resistant staphylococcal infection in a hospital could result in serious public health consequences, CDC and the Hospital Infection Control Practices Advisory Committee have developed interim guidelines to direct medical and public health responses when isolates of staphylococci with reduced vancomycin susceptibility are identified. (cdc.gov)
  • The aim of this study was to determine the occurrence of the icaA and icaD genes for slime production in a collection of staphylococcal clinical isolates by a simple, rapid, and reliable PCR method previously developed in our laboratory. (asm.org)
  • The search for ica genes was carried out in two S. epidermidis reference strains, 68 S. epidermidis isolates from intravenous catheter-associated infections, 23 S. aureus isolates from catheter-associated infections, and 10 S. epidermidis strains from the skin and mucosa of healthy volunteers. (asm.org)
  • A total of 86 staphylococcal isolates made up of 50 clinical isolates from urine samples submitted to the Medical Microbiology Laboratory of Ahmadu Bello University Teaching Hospital and 36 asymptomatic bacteriuria isolates from urine samples of 'healthy' volunteers within the university community were tested for their susceptibility to various antibiotics and production of b-lactamase enzyme. (ajol.info)
  • More recently, a mecA homologue- mecC -has been identified in some European staphylococcal isolates from humans and animals that exhibit methicillin resistance but lack the mecA gene. (todaysveterinarypractice.com)
  • Finally, the need for antimicrobial monitoring programmes is discussed and is supplemented with information pertaining to antimicrobial susceptibility testing and molecular typing of staphylococcal isolates. (intechopen.com)
  • 1 and 2 This report presents a case series of 3 PVL-positive community-acquired methicillin-sensitive S aureus (PVL CA-MSSA) infections treated by the maxillofacial team at the Southern General Hospital (Glasgow, United Kingdom) over a 6-month period in 2013 and discusses the clinical implications of PVL S aureus infections in this patient group. (gla.ac.uk)
  • Multidrug-resistant S. aureus infections continue to increase, and some strains respond to few, if any, conventional antibiotic therapies. (biomedcentral.com)
  • S. aureus infections are common in people with frequent skin injury, particularly if the skin is dry. (bestonlinemd.com)
  • aureus ) infections in mice. (nature.com)
  • Taken together, these results suggest that decreased MRSA transmission played a substantial role in reducing overall S. aureus infections at VAMCs. (medscape.com)
  • Up to 50,000 deaths each year in the USA are linked with S. aureus infections. (wikipedia.org)
  • Prior to the 1940s, S. aureus infections were fatal in the majority of patients. (wikipedia.org)
  • However, doctors discovered that the use of penicillin could cure S. aureus infections. (wikipedia.org)
  • The global Staphylococcal Infection Drugs market is fragmented and rely on strategies such as mergers & acquisitions, product development, geographical expansion, and sourcing strategies to enhance their market share. (advancemarketanalytics.com)
  • Research Analyst at AMA estimates that United States Players will contribute to the maximum growth of Global Staphylococcal Infection Drugs market throughout the predicted period. (advancemarketanalytics.com)
  • AdvanceMarketAnalytics has segmented the market of Global Staphylococcal Infection Drugs market by Type, Application and Region. (advancemarketanalytics.com)
  • Global Staphylococcal Infection Drugs Market 2019 by Company, Regions, Type and Application, Forecast to 2024 is an inclusive, professional analysis which demonstrates Staphylococcal Infection Drugs market data. (dispatchcorrespondent.com)
  • Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tubingen, 72076 Tübingen, Germany. (nih.gov)
  • Evaluate the microbiology of staphylococcal infection among hospitalized children. (cdc.gov)
  • 16,17 MRSP infections are now commonly reported in the veterinary literature and increasingly isolated by veterinary microbiology laboratories. (todaysveterinarypractice.com)
  • S. aureus commonly causes infections in the skin and soft tissue, bones, joints, and the respiratory system. (cancertherapyadvisor.com)
  • Although the reasons for this decline are unknown, possibilities include changes in the Staphylococcal organism itself, changes in outpatient management of MRSA skin and soft tissue infections, and effectiveness of local health department educational efforts. (cdc.gov)
  • Necrotizing cellulitis, myositis, and necrotizing fasciitis are types of necrotizing soft-tissue infections (NSTIs). (oncologynurseadvisor.com)
  • Administration of vancomycin to treat bloodstream infections requires intravenous delivery. (ama-assn.org)
  • In this study, CNS recovered from patients with bloodstream infections (BSIs) or prosthetic-device-associated infections (PDAIs) were compared in terms of biofilm formation, antimicrobial resistance, clonal distribution, and carriage of adhesin and toxin genes. (microbiologyresearch.org)
  • Although a few novel antibiotics have been recently introduced into clinical practice, the search for alternative strategies to efficiently combat staphylococcal infections is urgently demanded to decrease the enormous burden caused by pathogenic staphylococci. (nih.gov)
  • Infection (PJI) caused by methicillin-susceptible and methicillin-resistant staphylococci will be included and followed during 2 years. (bioportfolio.com)
  • Nevertheless, infections due to staphylococci have remained a serious therapeutic problem. (annals.org)
  • Staphylococci are one of the most common causes of community- and hospital-acquired infection. (cdc.gov)
  • Rare cases of infection in the United States (1) have been caused by coagulase-negative staphylococci with reduced susceptibility to vancomycin (minimum inhibitory concentration {MIC} greater than or equal to 8 ug/mL) * (2). (cdc.gov)
  • Over the last few years, several studies have been done to elucidate the structures and pathogenetic mechanisms by which staphylococci are able to cause severe and irreducible infections associated with biomaterials ( 4 , 13 , 22 ). (asm.org)
  • Methicillin-resistant staphylococci possess the mecA gene , carried on the mobile genetic element staphylococcal chromosome cassette mec (SCCmec), which encodes for an altered penicillin-binding protein (PBP2a). (todaysveterinarypractice.com)
  • Staphylococci account for most deep infections associated with orthopaedic device related infections. (gu.se)
  • This can lead to sepsis , a very serious immune response to infection. (medlineplus.gov)
  • Infants with clinical sepsis and culture-positive CoNS infection had lower mortality rates than infants with clinical sepsis and negative blood culture results. (pubmedcentralcanada.ca)
  • 1 year of age, the Centers for Disease Control and Prevention defines CoNS infection as the presence of clinical sepsis (e.g., hyperthermia, hypothermia, apnea, or bradycardia) and isolation of CoNS organisms, either cultured from two or more blood cultures drawn on separate occasions or obtained from at least one blood culture in a patient with an intravascular line, where the physician begins appropriate antimicrobial therapy. (pubmedcentralcanada.ca)
  • In this review, we will discuss the role of MDSCs in sepsis and infection and summarize our perspectives on their development and function in the spectrum of trained innate immune protection against fungal-bacterial sepsis. (mdpi.com)
  • Staph infection in the blood is called bacteremia or sepsis. (rxlist.com)
  • If a staph infection gets into the bloodstream, it can spread to other organs and cause severe and life-threatening infections called sepsis or bacteremia. (rxlist.com)
  • Evaluate the safety, PK and efficacy comparing Pagibaximab Injection to placebo in preventing staphylococcal sepsis in very low birth weight infants. (clinicaltrials.gov)
  • Phase 2b/3, randomized, double-blind, multicenter, placebo-controlled study evaluating the safety, efficacy and pharmacokinetics (PK) of pagibaximab (100 mg/kg/dose) in comparison to placebo for the prevention of staphylococcal sepsis in VLBW infants (600 -1200 grams). (clinicaltrials.gov)
  • The Number of Participants With Staphylococcal Sepsis From Study Days 0 to 35. (clinicaltrials.gov)
  • In children, these systemic (affecting the whole body) or disseminated infections frequently affect the ends of the long bones of the arms or legs, causing a bone infection called osteomyelitis. (encyclopedia.com)
  • Erythrocyte sedimentation rate and C-reactive protein may be helpful in patients with subacute or chronic infections such as osteomyelitis. (medscape.com)
  • When a staph infection gets into the bone it can cause osteomyelitis, a rare but serious joint infection. (rxlist.com)
  • MRSA has also been recognized with increasing frequency in community-acquired infections. (wikipedia.org)
  • Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year. (clinicaltrials.gov)
  • Endocarditis and bacteremia more commonly occur in patients with an MRSA infection, in comparison with those who have an MSSA infection. (cancertherapyadvisor.com)
  • The two widely recognized categories of MRSA infection are hospital-acquired (i.e. (cancertherapyadvisor.com)
  • Discover a Simple 3-Step Program to Permanently Eradicate Mrsa & Staph Infections Without Using Antibiotics. (aspeneducationgroup.com)
  • Get Rid of Your Staph / Mrsa Infection. (aspeneducationgroup.com)
  • The 12 Day Or Less MRSA Eradication System by Christine Dawson, a 3 year chronic MRSA infections former sufferers is released to help sufferers worldwide to beat MRSA faster, without antibiotics, just using natural remedies. (aspeneducationgroup.com)
  • For most users the methods inside this book will rebalance theirs skin natural complexion, so they will completely can forget about nasty MRSA infection ever existed. (aspeneducationgroup.com)
  • During the last 3 years of the study, hospitalizations with Staphylococcal infection, mostly MRSA infections, declined. (cdc.gov)
  • MRSA and methicillin-susceptible S. aureus (MSSA) infection rates among VAMC inpatients from 2005 to 2017 were assessed. (medscape.com)
  • Significant reductions in S. aureus infection following the VAMC intervention were led primarily by decreases in MRSA. (medscape.com)
  • Moreover, MRSA infection declines were much larger among patients not carrying MRSA at the time of admission than among those who were. (medscape.com)
  • Recent calls to withdraw infection control interventions designed to prevent MRSA transmission might be premature and inadvisable, at least until more is known about effective control of bacterial pathogen transmission in health care settings. (medscape.com)
  • Beginning in 2005, in response to high rates of methicillin-resistant S. aureus (MRSA) infections, the U.S. Department of Veterans Affairs (VA) piloted an MRSA prevention program in 18 VA medical centers (VAMCs). (medscape.com)
  • [ 1 ] To assess the impact of the intervention, the investigators tracked the incidence of MRSA and methicillin-susceptible S. aureus (MSSA) infections at 130 VAMCs from 2005 to 2017 and examined hospital-acquired MRSA colonization based on results of MRSA surveillance tests collected during the same period. (medscape.com)
  • Blood cultures may be positive for staphylococcal species, even when results from other cultures are negative. (medscape.com)
  • S. saprophyticus, another coagulase-negative species that is part of the normal vaginal flora, is predominantly implicated in uncomplicated lower genitourinary tract infections in young sexually active women. (wikipedia.org)
  • Other staphylococcal species have been implicated in human infections, notably S. lugdunensis, S. schleiferi, and S. caprae. (wikipedia.org)
  • No amplification products were observed with template DNA from nonstaphylococcal species, and the efficiency of amplification of staphylococcal targets was not adversely affected by the presence of DNA from other bacterial species in the same sample. (asm.org)
  • After repeat testing, if species identification and vancomycin test results are consistent, immediately contact the state health department (SHD) and CDC's Hospital Infections Program, National Center for Infectious Diseases, telephone (404) 639-6400, to report the occurrence of a 'presumptive' staphylococcal strain with reduced susceptibility to vancomycin and to obtain epidemiologic and laboratory assistance. (cdc.gov)
  • Staphylococcal species account for more than 50% of periprosthetic joint infections (PJI) and antimicrobial therapy with rifampin-based combination regimens has been shown effective. (biomedcentral.com)
  • More than 30 staphylococcal species are pathogenic. (mhmedical.com)
  • Latex kits designed to detect both protein A and clumping factor also distinguish S. aureus from other staphylococcal species. (mhmedical.com)
  • similar infections to S. aureus in some circumstances (for example, immunosuppression), particularly the species S. lugdunensis . (vic.gov.au)
  • A problematic species is S. aureus, which can be harmful for humans, but can also be a major cause of infections of the udder in dairy cows (bovine mastitis). (idw-online.de)
  • Investigators have recently used molecular techniques to classify 3 closely related staphylococcal species- S intermedius , S pseudintermedius , and S delphini -as the S intermedius group. (todaysveterinarypractice.com)
  • Phylogenetic separation of staphylococcal species and subspecies. (intechopen.com)
  • It has been proposed that one possible reason for the great deal of heterogeneity within the species could be due to its reliance on heterogeneous infections. (wikipedia.org)
  • The major concern with regard to the treatment of staphylococcal infections is the continued emergence of antibiotic-resistant strains. (asm.org)
  • Moreover, oxacillin-resistant strains are often resistant to other antimicrobial agents commonly used to treat staphylococcal infection ( 33 ). (asm.org)
  • To delay the emergence of resistant strains and prolong the utility of currently available antibiotics, it is imperative that the use of these drugs be restricted to those cases in which they are absolutely necessary, the primary example being a serious infection caused by an oxacillin-resistant strain. (asm.org)
  • In this study, the presence of icaA and icaD was determined in a collection of 91 staphylococcal (68 S. epidermidis and 23 S. aureus ) strains from intravenous catheter-associated infections, in 10 strains from the skin and mucosa of healthy volunteers, and in two reference strains by a PCR method. (asm.org)
  • Due to the prevalence of multidrug resistance in methicillin-resistant strains, empirical switching of antimicrobial classes when treating staphylococcal infections that fail to respond to first-line antimicrobials (particularly beta-lactams) is NOT recommended. (todaysveterinarypractice.com)
  • Furthermore, recent reports have indicated a high prevalence of community-acquired infections caused by multidrug-resistant strains of S. aureus in otherwise healthy individuals ( 3 ). (jimmunol.org)
  • In a retrospective longitudinal cohort study in 62 WG patients, we investigated the presence of the staphylococcal SAg genes sea, seb, sec, sed, see, tsst-1 and eta in S. aureus strains isolated from WG patients during an observation period of seven years. (nih.gov)
  • Effective S. aureus prevention strategies require a multifaceted approach that includes adherence to current CDC recommendations for preventing not only device- and procedure-associated infections, but also transmission of health care-prevalent strains. (medscape.com)
  • Pathogenic strains often promote infections by producing virulence factors such as potent protein toxins, and the expression of a cell-surface protein that binds and inactivates antibodies. (wikipedia.org)
  • Only a few strains of S. aureus are associated with infections in humans. (wikipedia.org)
  • Staphylococcal enterotoxin B (SEB) and botulinum toxin A (BotA) are common causes of food poisoning in humans and pose high risk as potential biological warfare agents. (infectioncontroltoday.com)
  • Staphylococcal infection in the lung of immunocompetent mice usually evokes a strong innate immune response dominated by infiltration of neutrophils and macrophages, mimicking the course of infection in humans ( 4 , 7 , 8 ). (jimmunol.org)
  • In humans, S. aureus is responsible for a variety of conditions, ranging from superficial skin infections to life-threatening diseases [ 6 ]. (intechopen.com)
  • Over time, this parasitic relationship has led to the bacterium's ability to be carried in the nasopharynx of humans without causing symptoms or infection. (wikipedia.org)
  • Here we demonstrate the rapid, simultaneous dose-dependent detection of staphylococcal enterotoxin B and botulinum toxin A, as measured using the Naval Research Laboratory array sensor say the researchers. (infectioncontroltoday.com)
  • 2005. Biosensor detection of botulinum toxoid A and staphylococcal enterotoxin B in food. (infectioncontroltoday.com)
  • Staphylococcal enterotoxin A, toxic shock syndrome toxin 1, and both exfoliative toxins triggered C3HeB/FeJ macrophages to secrete tumor necrosis factor alpha, but enterotoxin B induced only marginal amounts of tumor necrosis factor. (asm.org)
  • The current study developed an Escherichia coli protein expression system that produced a recombinant staphylococcal enterotoxin A (rSEA) encapsulated into biodegradable microparticles generated by polylactic-co-glycolic acid (PLGA) dissolved in methylene chloride and stabilized with polyvinyl acetate. (biomedcentral.com)
  • have investigated a double-mutant staphylococcal enterotoxin C (SEC) [ 15 ], that was devoid of superantigenic activity, as an intranasal vaccine for protection against S. aureus challenge in mice. (biomedcentral.com)
  • Staphylococcal enterotoxin B (SEB) is the toxin most commonly associated with classic food poisoning . (medscape.com)
  • Staphylococcal enterotoxin B (SEB) consists of 239 amino acid residues and has a molecular weight of 28 kd. (medscape.com)
  • Staphylococcal enterotoxin B (SEB) is a relatively stable compound that is easily soluble in water. (medscape.com)
  • Many of the effects of staphylococcal enterotoxin B (SEB) are mediated stimulation of T lymphocytes by the host's immune system. (medscape.com)
  • Immunotherapeutic strategies to combat staphylococcal infections. (nih.gov)
  • Taken together, these investigations will provide preclinical evidence for the therapeutic use of small molecule C5aR antagonists in man to combat staphylococcal infections. (grantome.com)
  • Coagulase-negative staphylococcal infections are more likely to be healthcare associated. (vic.gov.au)
  • Should first-line empiric treatment strategies cover coagulase-negative staphylococcal infections in severely malnourished or HIV-infected children in Kenya? (lshtm.ac.uk)
  • Are Phenotypic Criteria Adequate In Coagulase-Negative Staphylococcal Orthopaedic Implant-Associated Infections? (jbji.net)
  • Tevell S, Baig S, Nilsdotter-Augustinsson Å, Stegger M, Söderquist B. Same Organism, Different Phenotype - Are Phenotypic Criteria Adequate In Coagulase-Negative Staphylococcal Orthopaedic Implant-Associated Infections? (jbji.net)
  • Objectives Despite significant medical advances, infective endocarditis (IE) remains an infection associated with high morbidity and mortality. (ebscohost.com)
  • The spectrum of staph infections can range from a minor boil or skin abscess to life-threatening infections such as septicaemia (infection of the blood) or endocarditis (infection of the lining of the heart). (your.md)
  • Most of the acute bacterial infections of man respond promptly and predictably to the antimicrobial agents now available. (annals.org)
  • This new bacterial route to persistence has been first described in a dairy cow with a long-lasting, chronic udder infection with implications for animal welfare, food safety and milk yield. (idw-online.de)
  • It is a bacterial infection of the urinary tract, usually sexually transmitted. (soundhealthdoctor.com)
  • Skin infections are mainly treated with antibiotics and the choice of antibiotic depends on the type and severity of the infection as well as drug-resistance patterns of the particular bacterial type. (soundhealthdoctor.com)
  • Our study thus identifies a critical role for NK cells in host defense against pulmonary extracellular bacterial infection and suggests that IL-15 is involved in this process via its indispensable effect on NK cells, but not other innate cells. (jimmunol.org)
  • Introduction: Staphylococcal infection-related glomerulonephritis (GN) has been shown to represent a unique form of infection-related GN that contains IgA-dominant deposits and is often seen concurrently with the bacterial infection. (elsevier.com)
  • Both bacterial infections can occur individually, as well as in co-infection resulting in even worse outcomes. (kingston.ac.uk)
  • To prevent the looming era of untreatable bacterial infections, alternative treatment regimens that are cost effective and accessible are needed. (kingston.ac.uk)
  • Candidates such as N-nonanoic acid and palmitoleic acid were effective against both P. aeruginosa and S. aureus, demonstrating that the same fatty acids show potential to be used against both Gram negative and Gram positive bacterial infections. (kingston.ac.uk)
  • Infected pimples are typically caused by a bacterial infection. (medicalnewstoday.com)
  • The overall purpose of this research project is to create a deeper understanding of the role of bacterial colonisation and infection in chronic wounds, more specifically the impact of bacterial virulence to the pathogenicity will be studied. (gu.se)
  • The increasing prevalence of staphylococcal antimicrobial resistance, particularly methicillin resistance, presents a challenge to veterinary practitioners treating clinical infections. (todaysveterinarypractice.com)
  • Failure to recognize staphylococcal antimicrobial resistance frequently results in ineffective empiric therapeutic choices and protracted clinical disease. (todaysveterinarypractice.com)
  • Researchers from Washington, D.C. have developed a new method that may allow for rapid simultaneous detection of staphylococcal and botulinum toxins in food. (infectioncontroltoday.com)
  • We investigated the ability of staphylococcal enterotoxins A and B, exfoliative toxins A and B, and toxic shock syndrome toxin 1 to activate macrophages. (asm.org)
  • Staphylococcal toxins can also cause food poisoning. (bestonlinemd.com)
  • Infection incidence was calculated relative to all children and to those hospitalized in acute-care facilities. (cdc.gov)
  • Acute staphylococcal infections in rabbits irradiated with 3-GHz microwaves. (emf-portal.org)
  • The last mentioned is normally associated with chronic lid infections, and the acute purulent conjunctivitis, known more familiarly as pink eye , is usually caused by the pneumococcus. (aspeneducationgroup.com)
  • However, it is currently unclear whether children who are highly susceptible to infection because of severe acute malnutrition (SAM) or HIV should be treated with antimicrobials specifically to cover CoNS. (lshtm.ac.uk)
  • We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. (hindawi.com)
  • So, we concluded it as a puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement. (hindawi.com)
  • A female client with a severe staphylococcal infection is receiving the aminoglycoside gentamicin sulfate ( Garamycin ) by the I.V. route. (medihealthwriter.com)
  • However, anyone can develop a serious staphylococcal infection, including fit young people. (vic.gov.au)
  • Treatment for staph infections is antibiotics . (medlineplus.gov)
  • There are still certain antibiotics that can treat these infections. (medlineplus.gov)
  • The mecA gene, which is found in staphylococcal cassette chromosome SCC mec , codes for penicillin-binding protein (PBP) 2A, and this confers resistance to beta-lactam and non-beta-lactam antibiotics. (cancertherapyadvisor.com)
  • Treatment of a staph infection includes antibiotics, wound drainage, and device removal. (advancemarketanalytics.com)
  • Most staph skin infections are easily treated with antibiotics or by draining the infection. (premilife.com)
  • The diagnosis of staphylococcal skin infections should be confirmed by a positive laboratory culture of a swab from the infected site or blood culture. (bestonlinemd.com)
  • Conclusion: IgA-dominant GN with cryoglobulinemic features is an uncommon but severe form of glomerular injury in patients with staphylococcal infections. (elsevier.com)
  • Murine macrophage activation by staphylococcal exotoxins. (asm.org)
  • These results suggest that macrophages respond differently to several staphylococcal exotoxins. (asm.org)
  • Staphylococcal and streptococcal superantigen exotoxins. (biomedsearch.com)
  • Vancomycin is frequently prescribed for the management of infections in haemodialysis patients. (ebscohost.com)
  • Case of Vancomycin-Resistant Enterococcus faecium Infection Associated with a Transjugular Intrahepatic Portosystemic Shunt That Was Treated with Quinupristin/Dalfopristin After Bacteremia Persisted with Alatrofloxacin Therapy. (ebscohost.com)
  • Presents a case study of recurrent vancomycin-resistant Enterococcus faecium infection associated with a transjugular intrahepatic portosystemic shunts. (ebscohost.com)
  • Newer agent steps in as vancomycin fails with infections. (ebscohost.com)
  • Outlines a number of guidelines for the prevention and control of staphylococcal infections in correlation with reduced vancomycin susceptibility. (ebscohost.com)
  • In fact, because vancomycin has poor gastrointestinal absorption, the only infection it can effectively treat orally is Clostridium difficile . (ama-assn.org)
  • Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. (springer.com)
  • pathogens in infections primarily associated with prosthetic devices. (mhmedical.com)
  • Indwelling medical devices and prosthetic implants are targets for staphylococcal cell adherence and biofilm formation. (nebraska.edu)
  • Gries, CM & Kielian, T 2017, ' Staphylococcal biofilms and immune polarization during prosthetic joint infection ', Journal of the American Academy of Orthopaedic Surgeons , vol. 25, pp. (nebraska.edu)
  • In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
  • Thank you for sharing this Infection and Immunity article. (asm.org)
  • Message Body (Your Name) thought you would be interested in this article in Infection and Immunity. (asm.org)
  • Is there any immunity after staphylococcal infection? (healthtap.com)
  • People with diabetes or weakened immunity are particularly prone to developing this infection. (advancemarketanalytics.com)
  • Unsolved problems of these biomaterials are related to the risk of staphylococcal biofilm infections and to the low osteoconductivity of contemporary bioresorbable composite implants. (utupub.fi)
  • Symptoms for the most common types of staphylococcal skin infections are outlined below. (your.md)
  • Often, providers can tell if you have a staph skin infection by looking at it. (medlineplus.gov)
  • To check for other types of staph infections, providers may do a culture , with a skin scraping, tissue sample, stool sample, or throat or nasal swabs. (medlineplus.gov)
  • Staph skin infections often produce pus-filled pockets (abscesses) located just beneath the surface of the skin or deep within the body. (encyclopedia.com)
  • Most of these abscesses eventually burst, and pus leaking onto the skin can cause new infections. (encyclopedia.com)
  • Prophylactic measures against skin infections are essential. (hindawi.com)
  • How can one diagnose staphylococcal skin infection? (healthtap.com)
  • Which staphylococcal skin infection is considered the most serious? (healthtap.com)
  • Skin infections are the most common. (premilife.com)
  • Anyone can get a staph skin infection. (premilife.com)
  • Despite being harmless in most individuals, S. aureus is capable of causing various infections of the skin and other organs. (bestonlinemd.com)
  • skin infections are seen most commonly in pre-pubertal children and certain occupational groups such as healthcare workers. (bestonlinemd.com)
  • infections occur in normal individuals but underlying illness and certain skin diseases increase the risk of infection. (bestonlinemd.com)
  • While it is the leading cause of skin infection, it often causes no disease. (rxlist.com)
  • Symptoms of staphylococcal disease of the skin include pus-filled abscesses. (rxlist.com)
  • The infection causes a breakdown of the upper layers of the skin, which blisters and sloughs off, just like a severe burn. (rxlist.com)
  • In some cases an invasive infection can develop as a complication of a skin infection. (your.md)
  • Skin infections are usually mild and can be treated using antibiotic tablets or creams. (your.md)
  • Staphylococcal skin infections are common, particularly among children, teenagers and young adults. (your.md)
  • Staph infections most commonly affect the skin. (your.md)
  • The source of these infections is usually skin trauma or an existing lesion (such as an ulcer). (oncologynurseadvisor.com)
  • Staph infections may also cause impetigo, which is a highly contagious skin infection. (medicalnewstoday.com)
  • Although S. aureus usually acts as a commensal of the human microbiota it can also become an opportunistic pathogen, being a common cause of skin infections including abscesses, respiratory infections such as sinusitis, and food poisoning. (wikipedia.org)
  • for those suffering these kinds of infection, the body's own immune system is the only defense against the disease. (wikipedia.org)
  • Staphylococcal infections are frequent but are usually contained by immune mechanisms at the site of entry. (vic.gov.au)
  • Even though infections can affect healthy individuals, people with a weak immune system (for example, patients undergoing chemotherapy) are more prone to these infections. (news-medical.net)
  • This review describes the current understanding of how staphylococcal biofilms evade immune-mediated clearance to establish persistent infections. (nebraska.edu)
  • The present study evaluates the safety and efficacy of clindamycin in combination with rifampin for the management of staphylococcal PJI. (biomedcentral.com)
  • PURPOSE: Rifampin combination therapy plays an important role in the management of staphylococcal periprosthetic joint infection (PJI). (uzh.ch)
  • Daptomycin is a phosphatidylglycerol specific, calcium dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. (bioportfolio.com)
  • Combined therapy with clindamycin and rifampin is a safe, well tolerated and effective regimen for the treatment of staphylococcal periprosthetic infection. (biomedcentral.com)
  • Reinfection after treatment of first cerebrospinal fluid shunt infection: a prospective observational cohort study. (sickkids.ca)
  • For impetigo due to staphylococcal infection, exclude until appropriate treatment has commenced. (vic.gov.au)
  • Staph-related infections can range from being not severe and requiring no treatment to severe and potentially fatal. (soundhealthdoctor.com)
  • Duration of staph treatment actually depends on the kind of infection and disease the person has. (soundhealthdoctor.com)
  • Market Study Report, LLC, has added the latest research on ' Staphylococcal Infection Treatment market', which offers a concise outline of the market valuation, industry size, SWOT analysis, revenue approximation, and the regional outlook of this business vertical. (algosonline.com)
  • The report precisely features the key opportunities and challenges faced by contenders of this industry and presents the existing competitive setting and corporate strategies enforced by the Staphylococcal Infection Treatment market players. (algosonline.com)
  • The Staphylococcal Infection Treatment market research study incorporates a detailed analysis of this industry, alongside an appreciable gist of its segmentation. (algosonline.com)
  • The study includes a substantially viable evaluation of the current status of the Staphylococcal Infection Treatment market and also the market size adhering to the parameters of valuation and the volume. (algosonline.com)
  • What are the pointers that are enumerated in the Staphylococcal Infection Treatment market research report? (algosonline.com)
  • The price trends prevailing in the Staphylococcal Infection Treatment market as well as the estimated growth trends for this vertical. (algosonline.com)
  • Ukachukwu, Faith , Snyder, Lori and Alany, Raid (2020) Fatty acids as novel treatment options for 'Pseudomonad' and 'Staphylococcal' infection. (kingston.ac.uk)
  • A new diagnostic method is under evaluation to guide treatment decisions of orthopaedic infections caused by biofilms. (gu.se)
  • It is important to investigate if these infections have a biofilm origin and to determine the biofilm antimicrobial susceptibility to improve treatment strategies. (gu.se)
  • Finally, a deeper evaluation of the role of neutrophils and macrophages subtypes as well as their cooperation in promoting extravasation and activation of neutrophils and a better knowledge of the function of cytokines and T cells in promoting staphylococcal killing represent a critical step for planning of clinical trials and future vaccine development. (frontiersin.org)
  • Staphylococcal infection presents with a variety of clinical and epidemiological patterns among the general community, newborns, hospitalised patients, menstruating women and intravenous drug users. (vic.gov.au)
  • The systematic use of genome-sequence databases, gene expression technology, x-ray crystallography and animal studies have increased our appreciation of the structure and function of these virulence factors and mechanisms underlying host-staphylococcal interactions. (frontiersin.org)
  • The data reported indicate an important role of ica genes as a virulence marker in staphylococcal infections from intravenous catheters. (asm.org)
  • This is because of the greater virulence of S. aureus and the more significant role it plays in both community- and hospital-acquired infections. (vic.gov.au)
  • In spite of the reduction in peritonitis and catheter-related infection rates in patients undergoing peritoneal dialysis, these infections remain major sources of morbidity and transfer to haemodialysis. (ebscohost.com)
  • CoNS infections are associated with increased morbidity including neurodevelopmental impairment. (pubmedcentralcanada.ca)
  • Periprosthetic joint infections (PJI) cause significant morbidity and a considerable claim on the health care resource utilization. (biomedcentral.com)
  • What are the symptoms of staph infections? (medlineplus.gov)
  • The symptoms of a Staph Infection include a collection of pus, such as a boil or furuncle, or abscess. (wikipedia.org)
  • What are the symptoms of staphylococcal infection? (healthtap.com)
  • Which are the symptoms of localized staphylococcal infections? (healthtap.com)
  • Symptoms such as mild sticky eyelids, thicker margins of the eyelid, and missing eyelashes occur due to Staphylococcal blepharitis. (news-medical.net)
  • What Are the Signs and Symptoms of a Staph Infection? (rxlist.com)
  • Read more about the symptoms of staphylococcal infections . (your.md)
  • The symptoms of staphylococcal infections vary depending on the type of infection you have. (your.md)
  • 1. Visual alerts for patients at the entrance to ambulatory facilities instructing patients and accompanying persons to inform staff of symptoms of a respiratory tract infection when they first register for care and to practice respiratory hygiene and cough etiquette. (aappublications.org)
  • Staphylococcal (staph) infections are communicable infections caused by staph organisms and often characterized by the formation of abscesses. (encyclopedia.com)
  • Peritoneal Dialysis: Prevention and Control of Infection. (ebscohost.com)
  • Interim guidelines for prevention and control of staphylococcal infection associated with. (ebscohost.com)
  • Anyone can contract Staph, but pregnant women, children, and people with chronic diseases or who are immuno-deficient are often more susceptible to contracting an infection. (wikipedia.org)
  • Moreover, the pronounced capacity of PSMs to kill human neutrophils after phagocytosis might explain failures in the development of anti-staphylococcal vaccines. (nih.gov)
  • In particular, immunological strategies based on vaccine development or therapeutic antibodies may significantly enhance the efficiency of anti-staphylococcal therapy. (nih.gov)
  • Mobile genetic elements that are common in S. aureus include bacteriophages, pathogenicity islands, plasmids, transposons, and staphylococcal cassette chromosomes. (wikipedia.org)
  • Guidelines for the management of intravascular catheter-related infections. (medscape.com)
  • 68 Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUV ratio +58.1% and +41.7%, respectively). (utu.fi)
  • PET/CT imaging with novel 68 Ga-DOTA-Siglec-9 tracer was able to detect inflammatory tissue response induced by catheter implantation and staphylococcal infections. (utu.fi)
  • The third experiment (Study III) demonstrated that positron emission tomography (PET) imaging with the novel 68Ga labelled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) CD33 related sialic-acid immunoglobulin like lectins (Siglec-9) tracer was able to detect inflammatory response to S. epidermidis and S. aureus peri-implant infections in an intraosseous polytetrafluoroethylene catheter model. (utupub.fi)
  • A mild fever and/or an increase in the number of infection-fighting white blood cells may occur. (encyclopedia.com)
  • In this model the transmission of staphylococcal infection was assumed to occur after contact with the transiently colonized hands of HCWs, who, in turn, acquire contamination only by touching colonized patients. (biomedcentral.com)