Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Staphylococcus: A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.Floxacillin: Antibiotic analog of CLOXACILLIN.Staphylococcal VaccinesFurunculosis: A persistent skin infection marked by the presence of furuncles, often chronic and recurrent. In humans, the causative agent is various species of STAPHYLOCOCCUS. In salmonid fish (SALMONIDS), the pathogen is AEROMONAS SALMONICIDA.Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.Staphylococcus epidermidis: A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.Coagulase: Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.Staphylococcus haemolyticus: A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).Staphylococcal Skin Infections: Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Methicillin Resistance: Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.Phagocyte Bactericidal Dysfunction: Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas.Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.OsteomyelitisLysostaphin: A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique to an inter-peptide cross-bridge of the STAPHYLOCOCCUS AUREUS cell wall. EC 3.4.24.75.Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.Staphylococcus Phages: Viruses whose host is Staphylococcus.Skin Diseases, Infectious: Skin diseases caused by bacteria, fungi, parasites, or viruses.Nafcillin: A semi-synthetic antibiotic related to penicillin.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Bacteriophage Typing: A technique of bacterial typing which differentiates between bacteria or strains of bacteria by their susceptibility to one or more bacteriophages.Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.Prosthesis-Related Infections: Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).Staphylococcal Protein A: A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.Arthritis, Infectious: Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.Cross Infection: Any infection which a patient contracts in a health-care institution.Methicillin-Resistant Staphylococcus aureus: A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Teichoic Acids: Bacterial polysaccharides that are rich in phosphodiester linkages. They are the major components of the cell walls and membranes of many bacteria.Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Teicoplanin: Glycopeptide antibiotic complex from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.Acetamides: Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Nose: A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.Biofilms: Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Leukocidins: Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Blood Bactericidal Activity: The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.Superantigens: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Carrier State: The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.Bacterial Proteins: Proteins found in any species of bacterium.Streptococcal Infections: Infections with bacteria of the genus STREPTOCOCCUS.Enterotoxins: Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Time Factors: Elements of limited time intervals, contributing to particular results or situations.
Clindamycin plus gentamicin as expectant therapy for presumed mixed infections. (1/7250)
The prevalence of obligate anaerobes was studied prospectively in 60 patients with severe sepsis of intra-abdominal, soft tissue, female genital or oropulmonary origin. In addition, the efficacy of clindamycin (for anaerobes) plus gentamicin (for aerobic bacteria, especially coliforms) as initial empiric therapy in these patients was evaluated. Among 54 patients with cultural proof of infection, anaerobic pathogens were recovered from 52%. Nineteen patients had bacteremia; Bacteroides fragilis and Klebsiella pneumoniae were the most prevalent pathogens, being isolated in five patients each. Infection was eradicated in 56 of the 60 patients (93%). Mortality related to sepsis was 7% in the entire group, 16% in patients with bacteremia and 2% in patients without bacteremia. Eighty-five percent of aerobic isolates tested were susceptible in vitro to either gentamicin or clindamycin; 97% of anaerobic isolates were inhibited by 5 mug/ml of clindamycin. (+info)Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (2/7250)
BACKGROUND: Since the emergence of methicillin-resistant Staphylococcus aureus, the glycopeptide vancomycin has been the only uniformly effective treatment for staphylococcal infections. In 1997, two infections due to S. aureus with reduced susceptibility to vancomycin were identified in the United States. METHODS: We investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 microg per milliliter. To assess the carriage and transmission of these strains of S. aureus, we cultured samples from the patients and their contacts and evaluated the isolates. RESULTS: The first patient was a 59-year-old man in Michigan with diabetes mellitus and chronic renal failure. Peritonitis due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus peritonitis associated with dialysis. The removal of the peritoneal catheter plus treatment with rifampin and trimethoprim-sulfamethoxazole eradicated the infection. The second patient was a 66-year-old man with diabetes in New Jersey. A bloodstream infection due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus bacteremia. This infection was eradicated with vancomycin, gentamicin, and rifampin. Both patients died. The glycopeptide-intermediate S. aureus isolates differed by two bands on pulsed-field gel electrophoresis. On electron microscopy, the isolates from the infected patients had thicker extracellular matrixes than control methicillin-resistant S. aureus isolates. No carriage was documented among 177 contacts of the two patients. CONCLUSIONS: The emergence of S. aureus with intermediate resistance to glycopeptides emphasizes the importance of the prudent use of antibiotics, the laboratory capacity to identify resistant strains, and the use of infection-control precautions to prevent transmission. (+info)Alpha-toxin and gamma-toxin jointly promote Staphylococcus aureus virulence in murine septic arthritis. (3/7250)
Septic arthritis is a common and feared complication of staphylococcal infections. Staphylococcus aureus produces a number of potential virulence factors including certain adhesins and enterotoxins. In this study we have assessed the roles of cytolytic toxins in the development of septic arthritis by inoculating mice with S. aureus wild-type strain 8325-4 or isogenic mutants differing in the expression of alpha-, beta-, and gamma-toxin production patterns. Mice inoculated with either an alpha- or beta-toxin mutant showed degrees of inflammation, joint damage, and weight decrease similar to wild-type-inoculated mice. In contrast, mice inoculated with either double (alpha- and gamma-toxin-deficient)- or triple (alpha-, beta-, and gamma-toxin-deficient)-mutant S. aureus strains showed lower frequency and severity of arthritis, measured both clinically and histologically, than mice inoculated with the wild-type strain. We conclude that simultaneous production of alpha- and gamma-toxin is a virulence factor in S. aureus arthritis. (+info)Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. (4/7250)
Fifty-nine consecutive patients with definite Staphylococcus aureus infective endocarditis (IE) by the Duke criteria were prospectively identified at our hospital over a 3-year period. Twenty-seven (45.8%) of the 59 patients had hospital-acquired S. aureus bacteremia. The presumed source of infection was an intravascular device in 50.8% of patients. Transthoracic echocardiography (TTE) revealed evidence of IE in 20 patients (33.9%), whereas transesophageal echocardiography (TEE) revealed evidence of IE in 48 patients (81.4%). The outcome for patients was strongly associated with echocardiographic findings: 13 (68.4%) of 19 patients with vegetations visualized by TTE had an embolic event or died of their infection vs. five (16.7%) of 30 patients whose vegetations were visualized only by TEE (P < .01). Most patients with S. aureus IE developed their infection as a consequence of a nosocomial or intravascular device-related infection. TEE established the diagnosis of S. aureus IE in many instances when TTE was nondiagnostic. Visualization of vegetations by TTE may provide prognostic information for patients with S. aureus IE. (+info)Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (5/7250)
The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia. (+info)Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus. (6/7250)
The acquisition of iron by pathogenic bacteria is often a crucial step in establishing infection. To accomplish this, many bacteria, including Staphylococcus aureus, produce low-molecular-weight iron-chelating siderophores. However, the secretion and transport of these molecules in gram-positive organisms are poorly understood. The sequence, organization, and regulation of genes involved in siderophore transport are conserved among gram-negative bacteria. We used this information to identify a putative siderophore transport locus from an S. aureus genomic sequence database. This locus contains three predicted open reading frames with a high degree of homology to genes involved in siderophore uptake in several bacterial species, in particular the cbr locus of the plant pathogen Erwinia chrysanthemi. The first gene in the locus, which we have designated sir for staphylococcal iron regulated, encodes a putative lipoprotein with a molecular mass of 37 kDa. The open reading frame is preceded by a 19-bp region of dyad symmetry with homology for operator sequences controlling iron-regulated expression of genes in other bacteria. Fur titration experiments indicate that this region of dyad symmetry is sufficient for Fur-dependent regulation in Escherichia coli. The expression of this gene was repressed, in a dose-dependent manner, by the addition of iron to the S. aureus culture medium. sir-encoded proteins may be involved in iron acquisition in vivo and therefore may be targets for antimicrobial agents. (+info)Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospital. (7/7250)
The susceptibility of two collections of coagulase-negative staphylococci (CNS) isolated from clinical specimens for teicoplanin and vancomycin were compared. They comprised 91 and 101 isolates, collected in 1985 and 1994 respectively, from different departments of a teaching hospital. MICs of vancomycin and teicoplanin were determined by a modified Etest method. Additionally, a disc diffusion test was performed for teicoplanin. All isolates were susceptible to vancomycin (MIC < or = 4 mg/L). Two of the 91 isolates collected in 1985 were intermediate to teicoplanin (MIC between 8 and 32 mg/L), whereas in 1994 the number of intermediate isolates was 20 out of 101 (P < 0.01). The correlation between MICs, as determined by the modified Etest assay, and disc diffusion zones was poor (r = -0.35). Results show that resistance to teicoplanin in CNS has increased in the study hospital over a period of 9 years. This increase is likely to be correlated with the introduction of teicoplanin. Furthermore, a disc diffusion method does not appear to be the first method of choice for detection of strains of CNS with diminished susceptibility to teicoplanin. (+info)The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (8/7250)
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested. (+info)
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Staphylococcal infections - health.vic
The American Journal of Tropical Medicine and Hygiene | Fatal Staphylococcal Infection following Classic Dengue FeverStaphylococcal cassette chromosome mec (SCC mec) and arginine catabolic mobile element (ACME) in Staphylococcus epidermidis...Vancomycin for Staphylococcal Shunt Site Infections in Patients on Regular HaemodialysisNew Method for Simultaneously Detecting Staphylococcal and Botulinum Toxins in Food | Infection Control TodayMurine macrophage activation by staphylococcal exotoxins. | Infection and ImmunityStaphylococcal Infections in Children, California, USA, 1985-2009 - Volume 19, Number 1-January 2013 - Emerging Infectious...
International Symposium on Staphylococci and Staphylococcal Infections | Microbiology Microbes Bacteria Information and Links -...Interim Guidelines for Prevention and Control of Staphylococcal Infection Associated with Reduced Susceptibility to VancomycinEffect of protein A on staphylococcal opsonization. | Infection and ImmunityStaphylococcusMicrobiologyPathogenesisIsolatesMRSASepsisStaphylococciStaph infectionsClinicalIncidenceHospitalsBacterialVirulenceInvasive infectionsDecadeSkinDiagnosisMurinePreventingBacteriaStaph InfectionsNosocomialBloodstream infectionsBoilsSoft tissueScalded skin synToxinsHumansTypes of staphylococcalGlobal Staphylococcal Infection Drugs marketAureus infectionsAntibioticSpeciesEnterotoxinCombat staphylococcal infectionsCoagulase-negative staphylococcalImpetigoSerious Staphylococcal InfectionMethicillin-resistantEndocarditisDiagnosis of staphylococcalSevereProstheticImmunityRisk of staphylococcalIncidence of staphylococcalTreatmentPeriprosthetic joint infectionsManagement of staphylococcalSymptomsMorbidityExotoxinsImmuneCatheterSSSS
- Among staphylococci, Staphylococcus aureus is regarded as the most virulent species, while S. epidermidis, once considered harmless, is emerging as an important agent of nosocomial infections, particularly in association with indwelling medical devices. (frontiersin.org)
- Staphylococcal infections are a group of infections caused by the bacterium Staphylococcus. (your.md)
- There are many types of staphylococci, but most infections are caused by Staphylococcus aureus (S. aureus). (your.md)
- Nuclear imaging provides a platform for identifying sites of bacterial infection in the clinic more rapidly than traditional diagnostic microbiology laboratory methods allow. (springeropen.com)
- First, our knowledge of S. aureus pathogenesis in humans is rather preliminary and it is difficult to predict how animal data will equate to human infection. (frontiersin.org)
- The emergence of methicillin- and vancomycin- resistance among clinical isolates of S. aureus has made treatment of staphylococcal infections difficult and has revived research on vaccination and other strategies to prevent and treat staphylococcal infections especially in patients who are at high risk. (frontiersin.org)
- Staphylococcal infections can be life-threatening and are frequently complicated by multi-antibiotic resistant strains including methicillin-resistant S. aureus (MRSA). (springeropen.com)
- It causes a wide range of infections including skin and soft tissue (such as impetigo or abscesses), deep bone and foreign body infections that can lead to sepsis and pneumonia [ 22 ]. (springeropen.com)
- Staphylococci are among the most important human pathogens and a major cause of morbidity and mortality worldwide, causing septicaemia, pneumonia, endocarditis, osteomyelitis and post-operative infections. (frontiersin.org)
- Nevertheless, infections due to staphylococci have remained a serious therapeutic problem. (annals.org)
- You may have heard them referred to as staph infections. (your.md)
- The spectrum of staph infections can range from a minor boil or skin abscess to life-threatening infections such as septicaemia (infection of the blood) or endocarditis (infection of the lining of the heart). (your.md)
- Staph infections are caused when bacteria get into a break or cut in the skin. (your.md)
- Who gets staph infections? (your.md)
- Staph infections most commonly affect the skin. (your.md)
- Finally, a deeper evaluation of the role of neutrophils and macrophages subtypes as well as their cooperation in promoting extravasation and activation of neutrophils and a better knowledge of the function of cytokines and T cells in promoting staphylococcal killing represent a critical step for planning of clinical trials and future vaccine development. (frontiersin.org)
- Management of infection is a major clinical problem. (springeropen.com)
- It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials, although only a few studies to document this impression have appeared in the literature. (annals.org)
- Are you sure you want to remove Staphylococcal infections in hospitals from your list? (openlibrary.org)
- Most of the acute bacterial infections of man respond promptly and predictably to the antimicrobial agents now available. (annals.org)
- Selective uptake into bacteria in in vivo experimental murine infection models exploits the ability of bacterial cells to internalise alternative sugars to mammalian cells. (springeropen.com)
- This offers a strategy that could be exploited for imaging bacterial infection sites independent of host inflammatory responses. (springeropen.com)
- The systematic use of genome-sequence databases, gene expression technology, x-ray crystallography and animal studies have increased our appreciation of the structure and function of these virulence factors and mechanisms underlying host-staphylococcal interactions. (frontiersin.org)
- In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
- Invasive infections are more serious and usually treated in hospital with antibiotic injections. (your.md)
- During the last decade staphylococcal infections have become a problem of increasing concern. (annals.org)
- Skin infections are most common and usually cause symptoms such as boils or abscesses - painful, pus-filled lumps on the surface or just under the skin. (your.md)
- In some cases an invasive infection can develop as a complication of a skin infection. (your.md)
- Skin infections are usually mild and can be treated using antibiotic tablets or creams. (your.md)
- Staphylococcal skin infections are common, particularly among children, teenagers and young adults. (your.md)
- Symptoms for the most common types of staphylococcal skin infections are outlined below. (your.md)
- Therefore, developing new radiopharmaceuticals that enable rapid diagnosis of staphylococcal infections is imperative. (springeropen.com)
- Whole body biodistribution and accumulation of [ 18 F]FDG-6-P at the sites of bioluminescent staphylococcal infection were established in a murine foreign body infection model. (springeropen.com)
- Read more about preventing staphylococcal infections . (your.md)
- Some people carry staph bacteria on their skin or in their noses, but they do not get an infection. (medlineplus.gov)
- But if they get a cut or wound, the bacteria can enter the body and cause an infection. (medlineplus.gov)
- A localized staph infection is confined to a ring of dead and dying white blood cells and bacteria. (encyclopedia.com)
- Vaccines aimed at preventing S. aureus infection in bovine mastitis have been studied for many years, but have so far been unsuccessful due to the complexity of the bacteria, and the lack of suitable vaccine delivery vehicles. (biomedcentral.com)
- About 15-40 per cent of healthy humans are carriers of S. aureus, that is, they have the bacteria on their skin without any active infection or disease (colonisation). (bestonlinemd.com)
- Staphylococcal aureus bacteria are classified as Gram-positive cocci based on their appearance under a microscope. (bestonlinemd.com)
- In staphylococcal intoxications there may be no viable bacteria to culture and the diagnosis may be made retrospectively on the basis of a blood test demonstrating an immune response (seroconversion) to toxins following a compatible illness. (bestonlinemd.com)
- An easy remedy for nasal infections than can completely eradicate the presence of the bacteria in less than 7 days. (aspeneducationgroup.com)
- Following lung infection with PVL+ Staph (USA300), hC5aR-KI mice fail to clear the bacteria as efficiently as wild type animals, and their bronchoalveolar lavage fluid contains significantly elevated inflammatory cells. (grantome.com)
- Staph infections are caused when bacteria get into a break or cut in the skin. (your.md)
- Biofilm products actively suppress proinflammatory microbicidal responses,asevident bymacrophagepolarizationtoward ananti-inflammatory phenotype and the recruitment of myeloid-derived suppressor cells.With the rise in prosthetic hip and knee arthroplasty procedures, together with the recalcitrance of biofilm infections to antibiotic therapy, it is imperative to better understand themechanism of crosstalk between biofilm-associated bacteria and host immune cells. (nebraska.edu)
- Penicillin V oral tablet is used to treat certain infections caused by bacteria. (healthline.com)
- This kills off the bacteria that are causing your infection. (healthline.com)
- Staphylococcal enterotoxin B (SEB) is 1 of 7 originally identified enterotoxins produced by certain strains of the coagulase-positive S aureus bacteria, a gram-positive cocci that form clumps. (medscape.com)
- However, in bullous impetigo, the exfoliative toxins are restricted to the area of infection, and bacteria can be cultured from the blister contents. (medscape.com)
- The purpose of this study is to show whether Veronate, a donor-selected staphylococcal human immune globulin intravenous (IGIV), can prevent an infection in the blood caused by staphylococcal bacteria in premature babies weighing between 500 and 1250 grams at birth. (clinicaltrials.gov)
- Moreover, in the case of human medicine, the costs associated with the treatment of infections caused by antimicrobial-resistant bacteria represent a serious public health burden in hospital and community settings [ 10 ]. (intechopen.com)
- The most common cause of epiglottitis is infection with the bacteria called Haemophilus influenzae type b. (encyclopedia.com)
- Popping pimples can cause an infection because bacteria can enter the wound, or it can rupture the pustule inside the skin. (medicalnewstoday.com)
- In current diagnostic criteria for implant-associated bone- and joint infections, phenotypically identical low-virulence bacteria in two intraoperative cultures are usually required. (jbji.net)
- However, it is known that given the right circumstances, even if the staph infection arises from organisms present on one's body, if another person has direct contact with the infectious staph bacteria and has a break in the skin or mucous membranes, the organisms and potentially the disease can be contagious. (medicinenet.com)
- This is because many staph infections arise from bacteria that are already present on the skin and/or mucous membranes. (medicinenet.com)
- What are Staphylococcal (staph) infections? (medlineplus.gov)
- What causes staph infections? (medlineplus.gov)
- Who is at risk for staph infections? (medlineplus.gov)
- What are the symptoms of staph infections? (medlineplus.gov)
- How are staph infections diagnosed? (medlineplus.gov)
- To check for other types of staph infections, providers may do a culture , with a skin scraping, tissue sample, stool sample, or throat or nasal swabs. (medlineplus.gov)
- What are the treatments for staph infections? (medlineplus.gov)
- Treatment for staph infections is antibiotics . (medlineplus.gov)
- Can staph infections be prevented? (medlineplus.gov)
- Staphylococcal (staph) infections are communicable infections caused by staph organisms and often characterized by the formation of abscesses. (encyclopedia.com)
- A small fraction of localized staph infections enter the bloodstream and spread through the body. (encyclopedia.com)
- Discover a Simple 3-Step Program to Permanently Eradicate Mrsa & Staph Infections Without Using Antibiotics. (aspeneducationgroup.com)
- You may have heard them referred to as staph infections. (your.md)
- The spectrum of staph infections can range from a minor boil or skin abscess to life-threatening infections such as septicaemia (infection of the blood) or endocarditis (infection of the lining of the heart). (your.md)
- Who gets staph infections? (your.md)
- Staph infections most commonly affect the skin. (your.md)
- Staph infections may also cause impetigo, which is a highly contagious skin infection. (medicalnewstoday.com)
- Because many people carry several types and/or species of staph on their bodies, some researchers question whether or not some staph infections are truly contagious or if they arise from overgrowth of these organisms usually present on a person's skin and/or mucous membranes. (medicinenet.com)
- Injecting drug users, those with skin injuries or disorders, intravenous catheters, surgical incisions, and those with a weakened immune system due either to disease or a result of immune suppressing medications all have an increased risk of developing staph infections. (medicinenet.com)
- The incubation period for staph infections unfortunately is variable and considered to be indefinite. (medicinenet.com)
- However, for most staph infections, the incubation period commonly ranges from about four to 10 days. (medicinenet.com)
- The most common staph infections (for example, boils , impetigo , and MRSA ) occur in the skin. (medicinenet.com)
- Staph infections may occur in individuals of any age group. (medicinenet.com)
- They are the leading cause of primary infections originating in hospitals (nosocomial infections) in the United States . (encyclopedia.com)
- Antibiotic-resistant staphylococci are the leading cause of nosocomial infections in many hospitals around the world. (nih.gov)
- Since the late 1970s, methicillin-resistant S. aureus (MRSA) strains have been identified in Victoria as a major cause of nosocomial infections and outbreaks. (vic.gov.au)
- However, alcohol-based hand hygiene programs have been successfully associated with a reduction in the rates of nosocomial infections. (vic.gov.au)
- Through regular cleansing of hands, healthcare workers (HCWs) reduce the risk to transmitting nosocomial pathogens between patients and thus reduce the risk of exogenously-acquired infection. (biomedcentral.com)
- This organism is responsible for both nosocomial and community-based infections that range from relatively minor skin and soft tissue infections primarily to life-threatening systemic infections. (mhmedical.com)
- Staphylococcal species are a leading cause of community- and nosocomial-acquired infections, where the placement of foreign materials increases infection risk. (nebraska.edu)
- This perception is, however, changing as many species have emerged as important causes of nosocomial infections, particularly in relation to foreign-device-related infections and infections in immunocompromised patients [ 1 , 13 ]. (intechopen.com)
- Administration of vancomycin to treat bloodstream infections requires intravenous delivery. (ama-assn.org)
- In this study, CNS recovered from patients with bloodstream infections (BSIs) or prosthetic-device-associated infections (PDAIs) were compared in terms of biofilm formation, antimicrobial resistance, clonal distribution, and carriage of adhesin and toxin genes. (microbiologyresearch.org)
- Rates of MRSA bloodstream infections in hospitalized patients fell nearly 50% from 1997-2007 since hospitals began using prevention measures. (medicinenet.com)
- Skin infections can look like pimples or boils. (medlineplus.gov)
- Skin infections are most common and usually cause symptoms such as boils or abscesses - painful, pus-filled lumps on the surface or just under the skin. (your.md)
- Often, normal staph can result in minor epidermal infection like pimples or boils if the bacterium enters the epidermis through a sore or an open cut. (staphinfectionatoz.com)
- S. aureus commonly causes infections in the skin and soft tissue, bones, joints, and the respiratory system. (cancertherapyadvisor.com)
- Although the reasons for this decline are unknown, possibilities include changes in the Staphylococcal organism itself, changes in outpatient management of MRSA skin and soft tissue infections, and effectiveness of local health department educational efforts. (cdc.gov)
- Necrotizing cellulitis, myositis, and necrotizing fasciitis are types of necrotizing soft-tissue infections (NSTIs). (oncologynurseadvisor.com)
- Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTI) , oxacillin is an effective and recommended option for treatment of surgical site infections occurring after surgery of the trunk or extremity (away from the axilla or perineum). (drugs.com)
- Additionally, it can cause various skin and soft tissue infections, particularly when skin or mucosal barriers have been breached. (wikipedia.org)
- Rare in adults and most common in newborns and other children under the age of five, scalded skin syndrome originates with a localized skin infection. (encyclopedia.com)
- Any S. aureus infection can cause the staphylococcal scalded skin syndrome, a cutaneous reaction to exotoxin absorbed into the bloodstream. (wikipedia.org)
- Several bullous lesions affected his hands and feet (Figure 1 ) without formal argument for a necrotizing fasciitis or a staphylococcal scalded skin syndrome. (hindawi.com)
- Staphylococcal scalded skin syndrome (SSSS), which usually affects children less than five years old or rarely, adults with kidney failure. (bestonlinemd.com)
- Severity of staphylococcal scalded skin syndrome varies from a few blisters localized to the site of infection to a severe exfoliation affecting almost the entire body. (medscape.com)
- Two types of staphylococcal scalded skin syndrome are thought to exist: a localized form, in which there is only patchy involvement of the epidermis, and a generalized form, in which significant areas of are involved, remote from the initial site of infection. (medscape.com)
- [ 3 , 4 , 5 ] The relative quantity of DG-1 in the skin differs with age and may partially explain the increased frequency of staphylococcal scalded skin syndrome in children younger than 5 years. (medscape.com)
- The decrease in frequency of staphylococcal scalded skin syndrome (SSSS) in adults is thought to be explained by the presence of antibodies specific for exotoxins and also improved renal clearance of toxins that are produced. (medscape.com)
- Initial studies suggested that phage lytic group II S aureus (subtypes 3A, 3B, 3C, 55 and 71) were solely responsible for exfoliative toxin production, but it is now known that all phage groups are able to produce exfoliative toxin and cause staphylococcal scalded skin syndrome. (medscape.com)
- Staphylococcal scalded skin syndrome differs from bullous impetigo . (medscape.com)
- In staphylococcal scalded skin syndrome, the exfoliative toxins are spread hematogenously from a localized source potentially causing epidermal damage at distant sites. (medscape.com)
- Staphylococcal scalded skin syndrome differs from the more severe toxic epidermal necrolysis (TEN) , in that the cleavage site in staphylococcal scalded skin syndrome is intraepidermal, as opposed to TEN, which involves necrosis of the full epidermal layer (at the level of the basement membrane). (medscape.com)
- Staphylococcal scalded skin syndrome (SSSS) is most common in children and neonates. (medscape.com)
- Staphylococcal scalded skin syndrome is rarer in adults, but it has been described in adults with renal failure, immunologic deficiency, and other chronic illness. (medscape.com)
- Staphylococcal toxins are a common cause of food poisoning, as they can be produced in improperly-stored food. (wikipedia.org)
- Researchers from Washington, D.C. have developed a new method that may allow for rapid simultaneous detection of staphylococcal and botulinum toxins in food. (infectioncontroltoday.com)
- We investigated the ability of staphylococcal enterotoxins A and B, exfoliative toxins A and B, and toxic shock syndrome toxin 1 to activate macrophages. (asm.org)
- Staphylococcal enterotoxin A, toxic shock syndrome toxin 1, and both exfoliative toxins triggered C3HeB/FeJ macrophages to secrete tumor necrosis factor alpha, but enterotoxin B induced only marginal amounts of tumor necrosis factor. (asm.org)
- Staphylococcal toxins can also cause food poisoning. (bestonlinemd.com)
- Similarly, individuals who develop toxic shock syndrome have staph-produced toxins that are secreted from the infection site into the body. (medicinenet.com)
- Staphylococcal enterotoxin B (SEB) and botulinum toxin A (BotA) are common causes of food poisoning in humans and pose high risk as potential biological warfare agents. (infectioncontroltoday.com)
- Staphylococcal infection in the lung of immunocompetent mice usually evokes a strong innate immune response dominated by infiltration of neutrophils and macrophages, mimicking the course of infection in humans ( 4 , 7 , 8 ). (jimmunol.org)
- In humans, S. aureus is responsible for a variety of conditions, ranging from superficial skin infections to life-threatening diseases [ 6 ]. (intechopen.com)
- Symptoms for the most common types of staphylococcal skin infections are outlined below. (your.md)
- The global Staphylococcal Infection Drugs market is fragmented and rely on strategies such as mergers & acquisitions, product development, geographical expansion, and sourcing strategies to enhance their market share. (advancemarketanalytics.com)
- Research Analyst at AMA estimates that United States Players will contribute to the maximum growth of Global Staphylococcal Infection Drugs market throughout the predicted period. (advancemarketanalytics.com)
- AdvanceMarketAnalytics has segmented the market of Global Staphylococcal Infection Drugs market by Type, Application and Region. (advancemarketanalytics.com)
- Global Staphylococcal Infection Drugs Market 2019 by Company, Regions, Type and Application, Forecast to 2024 is an inclusive, professional analysis which demonstrates Staphylococcal Infection Drugs market data. (dispatchcorrespondent.com)
- S. aureus infections are common in people with frequent skin injury, particularly if the skin is dry. (bestonlinemd.com)
- aureus ) infections in mice. (nature.com)
- Taken together, these results suggest that decreased MRSA transmission played a substantial role in reducing overall S. aureus infections at VAMCs. (medscape.com)
- Up to 50,000 deaths each year in the USA are linked with S. aureus infections. (wikipedia.org)
- S. aureus infections can spread through contact with pus from an infected wound, skin-to-skin contact with an infected person, and contact with objects used by an infected person such as towels, sheets, clothing, or athletic equipment. (wikipedia.org)
- Daptomycin is a phosphatidylglycerol specific, calcium dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. (bioportfolio.com)
- Due to widespread antibiotic resistance, it is better to prevent staphylococcal infections where possible. (bestonlinemd.com)
- How to treat internal infections using a naturally occurring powerful antibiotic with a proven success rate. (aspeneducationgroup.com)
- The receptors for human C5a anaphylatoxin, C5aR and C5L2, were recently shown to act as binding sites for both PVL and ?HL/HlgCB, and we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
- Based on this finding, we hypothesize that small molecule antagonists of the C5a receptor will be useful in treating Staphylococcal infections as an adjunct to antibiotic therapy. (grantome.com)
- Skin infections are usually mild and can be treated using antibiotic tablets or creams. (your.md)
- Invasive infections are more serious and usually treated in hospital with antibiotic injections. (your.md)
- These findings hold implication for the development of therapeutics in treating antibiotic-resistant S. aureus infection. (jimmunol.org)
- S. saprophyticus, another coagulase-negative species that is part of the normal vaginal flora, is predominantly implicated in uncomplicated lower genitourinary tract infections in young sexually active women. (wikipedia.org)
- In recent years, several other staphylococcal species have been implicated in human infections, notably S. lugdunensis, S. schleiferi, and S. caprae. (wikipedia.org)
- No amplification products were observed with template DNA from nonstaphylococcal species, and the efficiency of amplification of staphylococcal targets was not adversely affected by the presence of DNA from other bacterial species in the same sample. (asm.org)
- similar infections to S. aureus in some circumstances (for example, immunosuppression), particularly the species S. lugdunensis . (vic.gov.au)
- After repeat testing, if species identification and vancomycin test results are consistent, immediately contact the state health department (SHD) and CDC's Hospital Infections Program, National Center for Infectious Diseases, telephone (404) 639-6400, to report the occurrence of a 'presumptive' staphylococcal strain with reduced susceptibility to vancomycin and to obtain epidemiologic and laboratory assistance. (cdc.gov)
- Staphylococcal species account for more than 50% of periprosthetic joint infections (PJI) and antimicrobial therapy with rifampin-based combination regimens has been shown effective. (biomedcentral.com)
- More than 30 staphylococcal species are pathogenic. (mhmedical.com)
- Latex kits designed to detect both protein A and clumping factor also distinguish S. aureus from other staphylococcal species. (mhmedical.com)
- Investigators have recently used molecular techniques to classify 3 closely related staphylococcal species- S intermedius , S pseudintermedius , and S delphini -as the S intermedius group. (todaysveterinarypractice.com)
- Phylogenetic separation of staphylococcal species and subspecies. (intechopen.com)
- Reactive arthritis occurs in 1% of people following infections with Campylobacter species. (wikipedia.org)
- Hemolytic uremic syndrome (HUS) may occur due to infection with Shiga toxin -producing Escherichia coli or Shigella species. (wikipedia.org)
- Here we demonstrate the rapid, simultaneous dose-dependent detection of staphylococcal enterotoxin B and botulinum toxin A, as measured using the Naval Research Laboratory array sensor say the researchers. (infectioncontroltoday.com)
- 2005. Biosensor detection of botulinum toxoid A and staphylococcal enterotoxin B in food. (infectioncontroltoday.com)
- The current study developed an Escherichia coli protein expression system that produced a recombinant staphylococcal enterotoxin A (rSEA) encapsulated into biodegradable microparticles generated by polylactic-co-glycolic acid (PLGA) dissolved in methylene chloride and stabilized with polyvinyl acetate. (biomedcentral.com)
- have investigated a double-mutant staphylococcal enterotoxin C (SEC) [ 15 ], that was devoid of superantigenic activity, as an intranasal vaccine for protection against S. aureus challenge in mice. (biomedcentral.com)
- Staphylococcal enterotoxin B (SEB) is the toxin most commonly associated with classic food poisoning . (medscape.com)
- Staphylococcal enterotoxin B (SEB) consists of 239 amino acid residues and has a molecular weight of 28 kd. (medscape.com)
- Staphylococcal enterotoxin B (SEB) is a relatively stable compound that is easily soluble in water. (medscape.com)
- Many of the effects of staphylococcal enterotoxin B (SEB) are mediated stimulation of T lymphocytes by the host's immune system. (medscape.com)
- Immunotherapeutic strategies to combat staphylococcal infections. (nih.gov)
- Taken together, these investigations will provide preclinical evidence for the therapeutic use of small molecule C5aR antagonists in man to combat staphylococcal infections. (grantome.com)
- Coagulase-negative staphylococcal infections are more likely to be healthcare associated. (vic.gov.au)
- Should first-line empiric treatment strategies cover coagulase-negative staphylococcal infections in severely malnourished or HIV-infected children in Kenya? (lshtm.ac.uk)
- Are Phenotypic Criteria Adequate In Coagulase-Negative Staphylococcal Orthopaedic Implant-Associated Infections? (jbji.net)
- Tevell S, Baig S, Nilsdotter-Augustinsson Å, Stegger M, Söderquist B. Same Organism, Different Phenotype - Are Phenotypic Criteria Adequate In Coagulase-Negative Staphylococcal Orthopaedic Implant-Associated Infections? (jbji.net)
- For impetigo due to staphylococcal infection, exclude until appropriate treatment has commenced. (vic.gov.au)
- However, anyone can develop a serious staphylococcal infection, including fit young people. (vic.gov.au)
- Infection (PJI) caused by methicillin-susceptible and methicillin-resistant staphylococci will be included and followed during 2 years. (bioportfolio.com)
- Methicillin-resistant staphylococci possess the mecA gene , carried on the mobile genetic element staphylococcal chromosome cassette mec (SCCmec), which encodes for an altered penicillin-binding protein (PBP2a). (todaysveterinarypractice.com)
- Objectives Despite significant medical advances, infective endocarditis (IE) remains an infection associated with high morbidity and mortality. (ebscohost.com)
- The diagnosis of staphylococcal skin infections should be confirmed by a positive laboratory culture of a swab from the infected site or blood culture. (bestonlinemd.com)
- is a life-threatening infection characterized by severe headache, sore throat, fever as high as 105 ° F (40.6 ° C), and a sunburn-like rash that spreads from the face to the rest of the body. (encyclopedia.com)
- We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. (hindawi.com)
- So, we concluded it as a puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement. (hindawi.com)
- Even though the number of fatalities related to dengue is unknown, several reports warn about the potential occurrence of severe infections and even death. (ajtmh.org)
- The autopsy revealed a severe disseminated staphylococcal disease and confirmed dengue infection. (ajtmh.org)
- Over the last few years, several studies have been done to elucidate the structures and pathogenetic mechanisms by which staphylococci are able to cause severe and irreducible infections associated with biomaterials ( 4 , 13 , 22 ). (asm.org)
- Fulminant staphylococcal infection indicates an explosive, intense, and severe infection occurring in a patient whose previous condition and antecedent would never have caused any anticipation of life-threatening development. (asmscience.org)
- Staph-related infections can range from being not severe and requiring no treatment to severe and potentially fatal. (soundhealthdoctor.com)
- However, it is currently unclear whether children who are highly susceptible to infection because of severe acute malnutrition (SAM) or HIV should be treated with antimicrobials specifically to cover CoNS. (lshtm.ac.uk)
- Epiglottitis is an infection of the epiglottis, which can lead to severe airway obstruction. (encyclopedia.com)
- Some bacterial infections cause severe abdominal pain and may persist for several weeks. (wikipedia.org)
- However, in poor countries treatment for severe infections is often out of reach and persistent diarrhea is common. (wikipedia.org)
- Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. (springer.com)
- pathogens in infections primarily associated with prosthetic devices. (mhmedical.com)
- Indwelling medical devices and prosthetic implants are targets for staphylococcal cell adherence and biofilm formation. (nebraska.edu)
- Gries, CM & Kielian, T 2017, ' Staphylococcal biofilms and immune polarization during prosthetic joint infection ', Journal of the American Academy of Orthopaedic Surgeons , vol. 25, pp. (nebraska.edu)
- In conclusion, this Research Topic focuses on the role of staphylococcal virulence factors in adhesion, invasion and biofilm formation on one hand and on their interaction with innate immunity on the other. (frontiersin.org)
- Thank you for sharing this Infection and Immunity article. (asm.org)
- Message Body (Your Name) thought you would be interested in this article in Infection and Immunity. (asm.org)
- Is there any immunity after staphylococcal infection? (healthtap.com)
- People with diabetes or weakened immunity are particularly prone to developing this infection. (advancemarketanalytics.com)
- Unsolved problems of these biomaterials are related to the risk of staphylococcal biofilm infections and to the low osteoconductivity of contemporary bioresorbable composite implants. (utupub.fi)
- It is generally believed that the incidence of staphylococcal infection has increased since the introduction of antimicrobials, although only a few studies to document this impression have appeared in the literature. (annals.org)
- Overall incidence is higher in developing countries and wherever the incidence of staphylococcal infections is higher. (medscape.com)
- Combined therapy with clindamycin and rifampin is a safe, well tolerated and effective regimen for the treatment of staphylococcal periprosthetic infection. (biomedcentral.com)
- Duration of staph treatment actually depends on the kind of infection and disease the person has. (soundhealthdoctor.com)
- Market Study Report, LLC, has added the latest research on ' Staphylococcal Infection Treatment market', which offers a concise outline of the market valuation, industry size, SWOT analysis, revenue approximation, and the regional outlook of this business vertical. (algosonline.com)
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- The study includes a substantially viable evaluation of the current status of the Staphylococcal Infection Treatment market and also the market size adhering to the parameters of valuation and the volume. (algosonline.com)
- What are the pointers that are enumerated in the Staphylococcal Infection Treatment market research report? (algosonline.com)
- The price trends prevailing in the Staphylococcal Infection Treatment market as well as the estimated growth trends for this vertical. (algosonline.com)
- Periprosthetic joint infections (PJI) cause significant morbidity and a considerable claim on the health care resource utilization. (biomedcentral.com)
- The present study evaluates the safety and efficacy of clindamycin in combination with rifampin for the management of staphylococcal PJI. (biomedcentral.com)
- PURPOSE: Rifampin combination therapy plays an important role in the management of staphylococcal periprosthetic joint infection (PJI). (uzh.ch)
- The symptoms of a Staph Infection include a collection of pus, such as a boil or furuncle, or abscess. (wikipedia.org)
- What are the symptoms of staphylococcal infection? (healthtap.com)
- Which are the symptoms of localized staphylococcal infections? (healthtap.com)
- Symptoms such as mild sticky eyelids, thicker margins of the eyelid, and missing eyelashes occur due to Staphylococcal blepharitis. (news-medical.net)
- Read more about the symptoms of staphylococcal infections . (your.md)
- The symptoms of staphylococcal infections vary depending on the type of infection you have. (your.md)
- 1. Visual alerts for patients at the entrance to ambulatory facilities instructing patients and accompanying persons to inform staff of symptoms of a respiratory tract infection when they first register for care and to practice respiratory hygiene and cough etiquette. (aappublications.org)
- Staphylococcal food poisoning produces symptoms of nausea , vomiting , diarrhea , and dehydration . (medicinenet.com)
- In spite of the reduction in peritonitis and catheter-related infection rates in patients undergoing peritoneal dialysis, these infections remain major sources of morbidity and transfer to haemodialysis. (ebscohost.com)
- CoNS infections are associated with increased morbidity including neurodevelopmental impairment. (pubmedcentralcanada.ca)
- Murine macrophage activation by staphylococcal exotoxins. (asm.org)
- These results suggest that macrophages respond differently to several staphylococcal exotoxins. (asm.org)
- Staphylococcal and streptococcal superantigen exotoxins. (biomedsearch.com)
- Staphylococcal infections are frequent but are usually contained by immune mechanisms at the site of entry. (vic.gov.au)
- Even though infections can affect healthy individuals, people with a weak immune system (for example, patients undergoing chemotherapy) are more prone to these infections. (news-medical.net)
- This review describes the current understanding of how staphylococcal biofilms evade immune-mediated clearance to establish persistent infections. (nebraska.edu)
- 68 Ga-DOTA-Siglec-9 PET detected inflammation induced by S. epidermidis and S. aureus catheter-related bone infections (SUV ratio +58.1% and +41.7%, respectively). (utu.fi)
- PET/CT imaging with novel 68 Ga-DOTA-Siglec-9 tracer was able to detect inflammatory tissue response induced by catheter implantation and staphylococcal infections. (utu.fi)
- The third experiment (Study III) demonstrated that positron emission tomography (PET) imaging with the novel 68Ga labelled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) CD33 related sialic-acid immunoglobulin like lectins (Siglec-9) tracer was able to detect inflammatory response to S. epidermidis and S. aureus peri-implant infections in an intraosseous polytetrafluoroethylene catheter model. (utupub.fi)
- [ 8 ] Some recent reports show an increase in hospitalizations and prescriptions for staphylococcal disease, including SSSS, in England. (medscape.com)
