Surgical procedure involving either partial or entire removal of the spleen.
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Enlargement of the spleen.
Tumors or cancer of the SPLEEN.
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Vein formed by the union (at the hilus of the spleen) of several small veins from the stomach, pancreas, spleen and mesentery.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.
An encapsulated lymphatic organ through which venous blood filters.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
ENDOSCOPES for examining the abdominal and pelvic organs in the peritoneal cavity.
The spontaneous transplantation of splenic tissue to unusual sites after open splenic trauma, e.g., after automobile accidents, gunshot or stab wounds. The splenic pulp implants appear as red-blue nodules on the peritoneum, omentum, and mesentery, morphologically similar to multifocal pelvic endometriosis. (Segen, Dictionary of Modern Medicine, 1992)
Disorders of the blood and blood forming tissues.
Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.
Surgical removal of the pancreas. (Dorland, 28th ed)
Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A subnormal level of BLOOD PLATELETS.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Infection of the spleen with species of MYCOBACTERIUM.
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
Anastomosis of splenic vein to renal vein to relieve portal hypertension.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Hemolytic anemia due to various intrinsic defects of the erythrocyte.
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
A congenital or acquired condition in which the SPLEEN is not in its normal anatomical position but moves about in the ABDOMEN. This is due to laxity or absence of suspensory ligaments which normally provide peritoneal attachments to keep the SPLEEN in a fixed position. Clinical symptoms include ABDOMINAL PAIN, splenic torsion and ISCHEMIA.
A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Individual's rights to obtain and use information collected or generated by others.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Abnormal passage communicating with the PANCREAS.
Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Intensive investigation in management of Hodgkin's disease. (1/1406)

Ninety-eight patients with clinically localised Hodgkin's disease underwent laparotomy and splenectomy to determine the extent of microscopic spread. In 68 patients the procedure was carried out for untreated disease apparently confined above the diaphragm. Abdominal disease cannot be confidently excluded on the basis of non-invasive investigation at presentation. Clinical assessment of splenic disease was unreliable unless gross splenomegaly was present. Pedal lymphography was accurate in assessing para-aortic and iliac disease but of no value in assessing other intra-abdominal lymph node involvement, including that of the mesenteric lymph node. Trephine bone marrow biopsy findings were normal in all patients before surgery, and only one patient was found to have diseased bone marrow by Stryker-saw biopsy at operation. Liver disease was identified at operation in nine patients, some of whom were asymptomatic with clinically undetectable splenic and nodal disease. Detailed clinical staging failed to detect disease in one-third of patients who underwent laparotomy. These studies show that if radiotherapy is to remain the treatment of choice for disease truly localised to lymph nodes a detailed staging procedure, including laparotomy and splenectomy, remains essential. The value of this potentially curative treatment is considerably diminished in the patient who has been inadequately staged.  (+info)

Immune response capacity after human splenic autotransplantation: restoration of response to individual pneumococcal vaccine subtypes. (2/1406)

OBJECTIVE: To evaluate features of general immune function, in particular the restoration of the humoral immune response to pneumococcal capsular polysaccharides, in humans undergoing a spleen autotransplantation after splenectomy because of trauma. SUMMARY BACKGROUND DATA: After splenectomy, patients have an increased risk of overwhelming infection or sepsis involving encapsulated bacteria such as pneumococci. The value of human spleen autotransplantation after splenectomy because of trauma has long been questioned. Mononuclear phagocyte system function appeared to be similar to that in splenectomized persons. The presence of specific antipneumococcal antibodies would allow other parts of the mononuclear phagocyte system, such as those in the liver, to phagocytose opsonized bacteria. METHODS: Ten consecutive patients undergoing splenectomy followed by autotransplantation were compared with the next 14 consecutive patients undergoing splenectomy alone. After a minimum of 6 months, the patients were vaccinated with 23-valent pneumococcal vaccine. Blood samples were taken at the time of vaccination and after 3 and 6 weeks for antipneumococcal capsular polysaccharides IgM and IgG enzyme-linked immunosorbent assay against types 3, 4, 6, 9, 14, and 23. Splenic regrowth was evaluated by scintigraphy. RESULTS: Surprisingly, several of the nonautotransplanted patients showed scintigraphic activity, indicating the presence of either accessory spleens or traumatic seeding (splenosis). Significant antibody titer increases (more than twofold) were found for both IgM and IgG in the autotransplanted patients. Splenectomized-only patients showed no significant increase in Ig levels in patients without splenic regrowth and partial improvement in patients with splenosis/accessory spleens. CONCLUSIONS: Considering this significant antipneumococcal antibody increase, spleen autotransplants can be expected to permit an adequate humoral response to pneumococcal infections and presumably also to other TI-2 antigens, and to protect against overwhelming postsplenectomy infection or sepsis.  (+info)

Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle. (3/1406)

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 +/- 3 to 20 +/- 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 +/- 0.79 vs. 4.79 +/- 0.73 l. min-1. m-2) and muscle perfusion (4.07 +/- 0.44 vs. 5.18 +/- 0.36 ml. 100 g-1. min-1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 +/- 0.06 vs. 0.48 +/- 0.03 ml O2. 100 g-1. min-1). Nevertheless, tissue PO2 was preserved (27.4 +/- 1.3 vs. 29.9 +/- 1. 4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 +/- 2.2 vs. 13.9 +/- 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.  (+info)

Implementing a policy for pneumococcal prophylaxis in a haematology unit after splenectomy. (4/1406)

People who have had a splenectomy for any reason are 40 times more likely to have an overwhelming infection, especially pneumococcal infection, and 17 times more likely to suffer fatal sepsis. The incidence of such life threatening infections is reduced by prophylactic immunisation with polyvalent pneumococcal vaccine and long term antibiotic prophylaxis or instituting prompt antibiotic treatment in the event of fever. This haematology unit agreed a policy of immunisation and antibiotic prophylaxis in June 1988 for all patients undergoing elective splenectomy. The success of this policy was audited in July 1993 by a retrospective analysis of patients' case notes. Seventy four patients were identified as having had a splenectomy, 54 (73%) before June 1988, of whom only 13 (24%) had received both pneumococcal immunisation and antibiotic prophylaxis before implementation of the agreed policy. At the time of audit, 46/74 (62%) patients were recorded as having received immunisation and 64/74 (86%) as receiving antibiotic prophylaxis or a supply of antibiotics to take in the event of a fever. All but one of the 20 patients who had a splenectomy after June 1988, since implementation of the agreed policy, received immunisation and antibiotic prophylaxis. The authors conclude that establishment of a formal agreed policy for pneumococcal prophylaxis for patients undergoing splenectomy has improved the quality of care.  (+info)

Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group. (5/1406)

Controversy still exists on the optimal surgical resection for potentially curable gastric cancer. Much better long-term survival has been reported in retrospective/non-randomized studies with D2 resections that involve a radical extended regional lymphadenectomy than with the standard D1 resections. In this paper we report the long-term survival of patients entered into a randomized study, with follow-up to death or 3 years in 96% of patients and a median follow-up of 6.5 years. In this prospective trial D1 resection (removal of regional perigastric nodes) was compared with D2 resection (extended lymphadenectomy to include level 1 and 2 regional nodes). Central randomization followed a staging laparotomy. Out of 737 patients with histologically proven gastric adenocarcinoma registered, 337 patients were ineligible by staging laparotomy because of advanced disease and 400 were randomized. The 5-year survival rates were 35% for D1 resection and 33% for D2 resection (difference -2%, 95% CI = -12%-8%). There was no difference in the overall 5-year survival between the two arms (HR = 1.10, 95% CI 0.87-1.39, where HR > 1 implies a survival benefit to D1 surgery). Survival based on death from gastric cancer as the event was similar in the D1 and D2 groups (HR = 1.05, 95% CI 0.79-1.39) as was recurrence-free survival (HR = 1.03, 95% CI 0.82-1.29). In a multivariate analysis, clinical stages II and III, old age, male sex and removal of spleen and pancreas were independently associated with poor survival. These findings indicate that the classical Japanese D2 resection offers no survival advantage over D1 surgery. However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial.  (+info)

Western immunoblot analysis of the antigens of Haemobartonella felis with sera from experimentally infected cats. (6/1406)

Cats were experimentally infected with a Florida isolate of Haemobartonella felis in order to collect organisms and evaluate the immune response to H. felis. Cryopreserved organisms were thawed and injected intravenously into nonsplenectomized and splenectomized cats. Splenectomized animals were given 10 mg of methylprednisolone per ml at the time of inoculation. Blood films were evaluated daily for 1 week prior to infection and for up to 60 days postinfection (p. i.). Blood for H. felis purification was repeatedly collected from splenectomized animals at periods of peak parasitemias. Organisms were purified from infected blood by differential centrifugation, separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and transferred to nitrocellulose membranes for immunoblot analysis. Serum was collected from nonsplenectomized animals prior to and for up to 60 days p.i. and was used on immunoblots to identify antigens. The combination of splenectomy and corticosteroid treatment resulted in marked, cyclic parasitemias without concurrent severe anemia, providing an opportunity to harvest organisms in a manner that was not lethal to the animals. Several antigens (150, 52, 47, 45, and 14 kDa) were identified. An antigen with a molecular mass of approximately 14 kDa appeared to be one of the most immunodominant and was consistently recognized by immune sera collected at various times during the course of infection. These data suggest that one or more of these antigens might be useful for the serologic diagnosis of H. felis infections in cats.  (+info)

Total gastrectomy with simultaneous pancreaticosplenectomy or splenectomy in patients with advanced gastric carcinoma. (7/1406)

A splenectomy or distal pancreaticosplenectomy is often performed simultaneously with total gastrectomy in the treatment of gastric carcinoma to facilitate dissection of the lymph nodes around the splenic artery and splenic hilus. However, the negative impact of splenectomy and pancreaticosplenectomy has also been reported. A retrospective analysis was performed to evaluate the outcomes of distal pancreaticosplenectomy and total gastrectomy, splenectomy and total gastrectomy, and gastrectomy alone in the patients with advanced gastric carcinoma without distant metastasis. Prognostic factors were examined. No significant differences existed in 5-year survival in the patients who underwent gastrectomy with splenectomy, gastrectomy with distal pancreaticosplenectomy, or gastrectomy alone. Neither splenectomy, nor distal pancreaticosplenectomy were prognostic factors. However, distal pancreaticosplenectomy was an independent predictor of pancreatic fistula. In conclusion, the addition of distal pancreaticosplenectomy or splenectomy to total gastrectomy for gastric cancer increases the risk of severe complications, but does not improve survival.  (+info)

Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. (8/1406)

Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder in which patients with poor prognostic features, receiving conventional treatments, have a median survival of less than 3 years. In this retrospective multicenter study, we analyze the results and try to define the indications for allogeneic stem cell transplantation in AMM. From January 1979 to November 1997, 55 patients with a median age of 42 years were transplanted from HLA-matched related (n = 49) or alternative (n = 6) donors for AMM. A multivariate analysis was conducted to identify factors associated with posttransplant outcome. The median posttransplant follow-up was 36 months (range, 6 to 223). The 5-year probability of survival was 47% +/- 8% for the overall group, and 54% +/- 8% for patients receiving an unmanipulated HLA-matched related transplant. The 1-year probability of transplant-related mortality was 27% +/- 6%. Hemoglobin level +info)

Background: Hypercoagulability in splenectomized patients with thalassemia intermedia (TI) has been extensively evaluated. However, clinical and laboratory characteristics of patients who eventually develop overt thromboembolic events (TEE) are poorly studied. Patients-Methods: Three Groups of TI patients (n = 73 each) were retrospectively identified from a registry involving six centers across the Middle East and Italy: Group I, all splenectomized patients with a documented TEE; Group II, age- and sex-matched splenectomized patients without TEE; and Group III, age- and sex-matched nonsplenectomized patients without TEE. Retrieved data included demographics, laboratory parameters, clinical complications, and received treatments that may influence TEE development, and reflected the period prior to TEE occurrence in Group I. Results: The mean age of Group I patients at development of TEE was 33.1 ± 11.7 years, with a male to female ratio of 33:40. TEE were predominantly venous (95percent) while ...
p,,strong,Background:,/strong, Total splenectomy, exposes children to the high risk of overwhelming postsplenectomy infections (OPSI). To avoid these adverse consequences, partial splenectomy has long been practiced for thalasseemia in children. It has been reported that the partial splenectomy keeps the child immunologically competent, hematologically stable with minimum blood transfusion and makes their life more comfortable in comparison to total splenectomy.,/p,,p,,strong,Objectives:,/strong, To compare the results of partial and total splenectomy.,/p,,p,,strong,Methodology:,/strong, This prospective interventional comperative study was done in the department of Pediatric Surgery, BSMMU from 2010 to 2012. Children who underwent partial splenectomy were considered as the case and who underwent total splenectomy as the control. Number of blood (RCC) transfusions (ml/ kg/year), Peripheral blood film (Hb%, WBC count, platelet count, Howell-Jolly body, serum bilirubin), volume of liver (ml), ...
The intoxication which is developed when splenectomized mice are fed with fresh spleen is more regular in occurrence when the feeding experiment is carried out four or five days after splenectomy than when it is done at later periods. The intoxication is easily recognizable even in its less severe forms by a lengthening of the coagulation time of the blood.. An intoxication of the same character is produced when splenectomized mice are fed with the mucous membrane of the stomach and upper small intestine. Bone marrow and dried blood probably give the same reaction in a somewhat milder form. The other organs either give no intoxication at all when fed, or in certain instances the thyroid, adrenal, and salivary gland (mouse) give intoxications of a different character which affect intact mice and splenectomized animals equally.. The spleen or the gastro-intestinal mucosa is equally effective in producing the intoxication, whether it be derived from heterologous or homologous species.. Certain ...
The intoxication which is developed when splenectomized mice are fed with fresh spleen is more regular in occurrence when the feeding experiment is carried out four or five days after splenectomy than when it is done at later periods. The intoxication is easily recognizable even in its less severe forms by a lengthening of the coagulation time of the blood. An intoxication of the same character is produced when splenectomized mice are fed with the mucous membrane of the stomach and upper small intestine. Bone marrow and dried blood probably give the same reaction in a somewhat milder form. The other organs either give no intoxication at all when fed, or in certain instances the thyroid, adrenal, and salivary gland (mouse) give intoxications of a different character which affect intact mice and splenectomized animals equally. The spleen or the gastro-intestinal mucosa is equally effective in producing the intoxication, whether it be derived from heterologous or homologous species. Certain ...
|p| To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splenectomy and porto-azygos devascularization operation time was 2.56 + 0.62 hours. The intraoperative bleeding and anal exhaust time was 149.5 + 32.7ml 3.47 + 1.32 days, and the hospitalization time was 5.05 + 1.22 days. When the spleen volume was greater than or equal to 1.5 liters, the rate of open abdominal surgery increased significantly. After 1, 2, 3, and 4 years of follow-up, cumulative recurrence bleeding rates were 0, 5.20%, 9.98%, and 15.83%, respectively. Laparoscopic splenectomy and pericardial devascularization is safe, effective, and feasible, and it can be confirmed by enhanced spiral computed tomography (CT). Whether spleen volume greater than 1.5L is suited to laparoscopic
To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splenectomy and porto-azygos devascularization operation time was 2.56 + 0.62 hours. The intraoperative bleeding and anal exhaust time was 149.5 + 32.7ml 3.47 + 1.32 days, and the hospitalization time was 5.05 + 1.22 days. When the spleen volume was greater than or equal to 1.5 liters, the rate of open abdominal surgery increased significantly. After 1, 2, 3, and 4 years of follow-up, cumulative recurrence bleeding rates were 0, 5.20%, 9.98%, and 15.83%, respectively. Laparoscopic splenectomy and pericardial devascularization is safe, effective, and feasible, and it can be confirmed by enhanced spiral computed tomography (CT). Whether spleen volume greater than 1.5L is suited to ...
In hereditary spherocytosis and in some cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production. In these conditions the immediate effect of splenectomy on red cell production is usually obscured by preoperative transfusions or by autotransfusions from the surgically manipulated spleen. The resulting increase in hemoglobin concentration would be expected to cause a prompt decrease in erythropoietic activity. In two recent cases, one of a patient with hereditary spherocytosis and the other of a patient ...
MOHAMMED N, Bani Hani. et al. Laparoscopic splenectomy: Consensus and debatable points. S. Afr. j. surg. [online]. 2010, vol.48, n.3, pp.81-84. ISSN 2078-5151.. INTRODUCTION: The emergence of minimally invasive techniques has broadened interest in splenectomy for a variety of haematological illnesses. Laparoscopic splenectomy (LS) is currently considered the gold standard for the treatment of various haematological disorders. PURPOSE: The literature was reviewed to highlight points of consensus and debatable points regarding best practice in LS, looking at issues such as bleeding and conversion, splenomegaly, splenic retrieval techniques, types of instruments used, hand-assisted LS (HALS), complications, approaches, accessory spleen and splenosis. Our goal was to share our experience with LS and compare it with other reports. BACKGROUND: LS has emerged as the standard of care for elective splenectomy for benign haematological diseases. However, doubts have been raised regarding the suitability ...
The value of prophylactic vaccinations and antibiotic treatment in post-splenectomy patients: a review AJ Jolanda LammersDepartment of Infectious diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The NetherlandsAbstract: Although spleen preservation surgery and non-operative management are first-line treatment options, total splenectomy is frequently performed. Splenectomy is performed for a number of indications including idiopathic thrombocytopenic purpura, high-energetic trauma, and hematological malignancy. Following splenectomy, patients are at risk for overwhelming post-splenectomy infection (OPSI), a syndrome that presents with mild symptoms at onset but irreversible multi-organ-failure occurs within hours to days. Since the spleen plays an important role in the immune response to polysaccharide antigens, encapsulated bacteria such as pneumococci are the most frequently described causative organisms of OPSI. Although the incidence of OPSI is low, the associated mortality
The FDA has approved Nplate (romiplostim) for the treatment of thrombocytopenia in splenectomized and non-splenectomized adults with chronic immune thrombocytopenic purpura (ITP).. In two Phase III studies of the drug, which works by raising and sustaining platelet counts, the overall response rate for romiplostim was 79% in splenectomized patients and 88% in non-splenectomized patients. Platelet counts were raised and sustained in the six-month studies, and patients were able to reduce or discontinue their use of concomitant ITP medications and emergency medications.. Nplates manufacturer, Amgen, also announced that it is launching the Nplate NEXUS (Network of Experts Understanding and Supporting Nplate and Patients) Program, to provide comprehensive access, support, and education for chronic ITP patients and their caregivers, and health care providers. The program is part of the Risk Evaluation and Mitigation Strategy developed by Amgen in partnership with the FDA to assure safe use of ...
Boeryd, B and Hagmar, B, Influence of splenectomy on intravenously induced and spontaneous metastases in mice. (1969). Subject Strain Bibliography 1969. 418 ...
European clinical trials of gastrectomy showed that splenectomy is an important risk factor for post-operative morbidity and mortality. Retrospective comparisons suggested that splenectomy is associated with poor long term survival. However, Japanese studies revealed that 20 - 30 % of patients with non-early carcinoma in the proximal stomach have nodal metastasis in the splenic hilum and therefore, pancreas-preserving splenectomy is part of the standard operation in specialized centers where splenectomy is not considered a risk factor for operative mortality. There have been no prospective randomized trials to evaluate the survival benefit of splenectomy in total gastrectomy for proximal gastric cancer.. Comparison: Total gastrectomy with pancreas-preserving splenectomy versus total gastrectomy without splenectomy ...
|p||p||bold|The aim of the study.|/bold| Retrospective analysis of indications for splenectomy in hematological diseases, positive effect of this operation and correlations between objective prognostic factors and good response to splenectomy in patients with different hematological indications for splenectomy.|/p||p||bold|Material and methods.|/bold| 98 adult patients with hematological disorders, who were splenectomised in the years 1994 - 2004. We evaluated the effects of splenectomy in patients with hematological diseases as defined by patient documentation from the 2|sup|nd|/sup| Department of General and Oncological Surgery, Department of Hematology and Hematological Ambulance and the questionnaires that patients completed by themselves.|/p||p||bold|Results.|/bold| The beneficial effect of splenectomy was observed in the majority of cases of idiopathic thrombocytopenic purpura (41 of 53 patients), acquired hemolytic anemia (2 of 3 patients) and hereditary spherocytosis (8 of 9
Objective: To determine the response to IV anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi. Methods: A total of 23 patients with chronic ITP were treated with either anti-D or splenectomy as second line treatment. The patients were assessed for time to achieve a response to second line treatment, duration ofresponse and adverse events. Results: There were 12 patients in the anti-D group and 11 in the splenectomy group. The mean platelet count at presentation was 9,000/cumm. The mean age was 8.9 years and 13.0 years and the male to female ratio was 1:1 and 1:1.2 in anti-D and splenectomy group respectively. 54.5% of the patient in the anti-D group responded compared to 81.8% in the splenectomy group. Median time to achieve a response was 7 days in the anti-D group and 1 day in the splenectomy group. Mean time to relapse was 87.8 days in the anti-D group and 55.4 days in the splenectomy
The Wiskott-Aldrich syndrome is an X-linked immunodeficiency disorder consisting of the triad of frequent infections, eczema, and profound thrombocytopenia. We evaluated the effects of splenectomy on hemostatic improvement and subsequent clinical course in 16 patients with the Wiskott-Aldrich syndrome. All 16 had an increase in platelet counts to at least 100,000 per cubic millimeter after splenectomy, with the mean increasing from 19,900 per cubic millimeter preoperatively to 262,700 per cubic millimeter after splenectomy. In addition, platelet size, which is characteristically small in this disease, also became normal. Survival after splenectomy correlated with the prophylactic use of antibiotics. Five of seven patients not taking prophylactic antibiotics died of sepis within 33 months of surgery. The mean survival of the nine patients maintained with prophylactic antibiotics, however, was at least 91.4 months, with six of these patients still alive an average of 11.0 years or more after splenectomy.
Method: The decision model compared a cohort of 1,000 people covered by a registry to a cohort of 1,000 people with no registry. The impact of the registry was assessed in terms of achieved rates of vaccination, chemoprophylaxis and education, consequent outcomes of overwhelming post-splenectomy infection (OPSI) and mortality (years of life lived). The cost-effectiveness of the registry compared with no registry was estimated in terms of additional cost per case of OPSI avoided and as additional cost per life year gained ...
Primary Objective: To determine the safety of PBSC mobilization with G-CSF, with or without HU pretreatment in adults with beta thalassemia major.. Secondary Objective: To determine the number of CD34+ stem/progenitor cells that are mobilized under these conditions, as well as the ability of these cells to be transduced with a recombinant lentivirus vector for beta-globin and engraft immunodeficient mice.. Study Design: The ability of G-CSF to safely and effectively mobilize PBSC in adults with beta thalassemia major will be assessed in 12 splenectomized and 12 non-splenectomized patients. Of the 12 splenectomized patients, 6 will be treated with HU and G-CSF, and 6 will be treated only with G-CSF. Likewise, of the 12 non-splenectomized patients, 6 will be treated with HU and G-CSF, and 6 will be treated only with G-CSF. G-CSF mobilized participants will undergo leukapheresis on 2 consecutive days, with a target yield of 2 million CD34+ cells per kg of body weight. Safety will be assessed by ...
Pivotal Phase 3 Romiplostim Study in Splenectomized Patients Meets Primary Endpoints Data Show Romiplostim Increased and Sustained Platelet Counts in Splenectomized Adult Patients with Immune Thrombocytopenic Purpura ATLANTA--(BUSINESS WIRE)--Dec. 8, 2007--Amgen Inc. (NASDAQ:AMGN) today announced results from a randomized, pivotal Phase 3 study that showed romiplostim (AMG 531) increased and sustained platelet counts in splenectomized (spleen removed) adult patients with chronic Immune Thrombocytopenic Purpura (ITP). Additionally, romiplostim-treated patients taking concurrent ITP medications such as corticosteroids were able to reduce or discontinue these medications. Adult ITP is a serious chronic autoimmune disorder characterized by low platelet counts in the blood, a condition known as thrombocytopenia. These Phase 3 data will be presented in a Plenary Session at the American Society of Hematology (ASH) 49th Annual Meeting in Atlanta, GA (Abstract #2).. The majority of available therapies ...
TY - JOUR. T1 - Splenectomy does not cure the thrombocytopenia of systemic lupus erythematosus. AU - Hall, S.. AU - McCormick, J. L.. AU - Greipp, P. R.. AU - Michet, C. J.. AU - McKenna, C. H.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Fourteen patients with systemic lupus erythematosus had splenectomies done between 1960 and 1982 for treatment of severe thrombocytopenia. Thrombocytopenia persisted or recurred within 1 month postoperatively in five patients and within 6 months in three others. Three patients had late recurrence (18, 30, and 54 months after splenectomy); in two cases it was probably related to withdrawal of immunosuppressive agents or corticosteroids. Median lowest platelet count before splenectomy and median platelet count at relapse or failure of splenectomy were both 8000/μL. Only two patients maintained normal platelet counts without need for corticosteroids or other treatment. These results differ from those in patients with idiopathic thrombocytopenic purpura. Other treatments ...
Background: Laparoscopic splenectomy (LS) has been established as a safe and effective alternative to open splenectomy (OS) for the treatment of appropriate patients with hematologic disease. The purpose of this study was to review our teaching institutions experience with splenectomy for hematologic disease.. Methods: Between 1996 and 2005 a total of 101 consecutive splenectomies were performed for both benign (53) and malignant (48) hematologic diseases by a single surgeon. These cases were reviewed for their post-operative outcomes, with particular attention to surgical approach (LS vs. OS), conversions, and complications. Results: 61% of patients underwent planned LS, with a 79% success rate. Patients with malignant disease were significantly older (p< 0.005), had larger spleens (p< 0.007), (40 cases of splenomegaly), more likely to undergo OS (p< 0.0009, 13 attempted LS, 62% success rate), and had longer length of stay (p< 0.02). However, there was no significant difference in OR time, ...
The elucidation of splenic function in health and disease has been continuously evolving since Aristotle dismissed the concept that it is essential for human existence more than 2000 years ago. The first recorded splenectomy was performed by Zaccarelli in 1549 for presumed malaria in a young woman who survived at least 6 years postoperatively [1]. The nonessential nature of the spleen was reinforced in subsequent animal experimentation following Reads successful splenectomy in a dog in 1638 [2]. Quittenbaum [3], in 1826, is credited with the initial well-documented splenectomy in a young woman with probable portal hypertension and splenomegaly. The patient expired postoperatively from exsanguination. Despite this dismal early outcome, splenectomy became an acceptable practice for idiopathic hypertrophy, malarial hypertrophy, splenic anemia, leukemia, cysts, and tuberculosis, with an associated mortality rate of 13% by 1908 [4].
The spleen is an intraperitoneal organ that performs vital hematological and immunological functions. which is defined as a generalized non-specific flu-like prodrome followed by rapid deterioration to full-blown fulminant septic Tmem1 shock within 24-48 hours of the onset [9]. Although there is no specific diagnostic criterion for OPSI, prompt identification followed by proper management can prevent further deterioration and fatality [25]. The prevalence of OPSI following splenectomy is 0.1-0.5%, with a mortality rate of up to 50% [26]. The period of?highest risk for infections is during the first 3 years post-splenectomy; however, the risk Saxagliptin (BMS-477118) remains elevated throughout an individuals lifespan, indicated by the reported occurrence of cases of fulminant infection 20 years after splenectomy?[6]. Children under 2-5 years of age, those who have had splenectomy post-trauma, individuals splenectomized for hematological malignancy or malignant conditions, and immunosuppressed or ...
Overwhelming postsplenectomy infection is a rare but serious disease that can occur after splenectomy. It is important for physicians to be familiar with it since delayed diagnosis or inadequate treatment causes high mortality. The objective of this article is to heighten awareness of physicians regarding this disease through a case report. Here we present a 70-year-old male patient who had a splenectomy for myelofibrosis. He developed recurrent upper respiratory and skin infections after splenectomy. Eventually, he died due to severe multisystem infection and having sepsis for six months postoperatively despite aggressive resuscitation and treatment. Rapid identification of patients at risk for the disease and early treatment may be the only chance to reduce the high mortality rate of this disease.. ...
TY - JOUR. T1 - Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis. AU - Masuya, Masahiro. AU - Shiraki, Katsuya. AU - Sugimoto, Kazushi. AU - Yamamoto, Norihiko. AU - Yoneda, Misao. AU - Kanayama, Kazuki. AU - Nishikawa, Kenichiro. AU - Ino, Kazuko. AU - Tawara, Isao. AU - Ohishi, Kohshi. AU - Sakurai, Hiroyuki. AU - Usui, Masanobu. AU - Shiraishi, Taizo. AU - Isaji, Shuji. AU - Takei, Yoshiyuki. AU - Katayama, Naoyuki. N1 - Publisher Copyright: © 2014 The Japan Society of Hepatology.. PY - 2014/12/1. Y1 - 2014/12/1. N2 - Aim: The spleen is not believed to contribute to hematopoiesis in healthy adults. However, several reports have demonstrated that the spleen in adults contains a large number of hematopoietic stem/progenitor cells (HSC). Although splenectomy increases platelet and leukocyte counts, the effects of splenectomy on circulating HSC have not been elucidated. In this study, we evaluated ...
This report describes a case of isolated diffuse haemangiomatosis in the spleen of a nine-month-old dog that presented with weakness, abdominal discomfort and severe splenomegaly. Histopathological examination following splenectomy showed the splenic parenchyma had almost been replaced by multiple dilated vascular lacunae, varying is size, and lined by a single layer of flattened, well differentiated, endothelial cells sustained by fine fibrocystic bundles. The cytoplasmic expression of CD34 and von Willebrand factor found in the endothelial cells confirmed the vascular nature of the lesion; the lack of expression of podoplanin, a specific marker for the lymphatic vessels, excluded the diagnosis of lymphangiomatosis. Diffuse splenic haemangiomatosis carries a benign prognosis and complete cure following splenectomy has been described in humans and was achieved in this case. However, the differential diagnosis must take into account the possibility of vascular malignant or tumour-like lesions ...
The diagnosis of a post-splenectomy/hyposplenic blood picture can be made reliably by identifying Howell Jolly bodies in routine Wright-Giemsa stained blood. These are round basophilic bodies in red blood cells that represent residual nuclear material from marrow nucleated red cell precursors that are usually culled out by the spleen (Fig 1, Table 1). These do not occur in individuals with normally functioning splenic tissue and their presence indicates either 1) an asplenic state or 2) hypofunctioning splenic tissue as might be seen in a patient with late-stage sickle cell anemia. Their presence in an individual with splenomegaly leads to a narrow differential diagnosis (Table 2) and their absence in a splenectomized individual indicates accessory splenic Heinz bodies and poikilocytosis typically increase in a splenectomized individual and care must be taken not to overdiagnose hemolysis in such an individual. Benign poikilocytosis can be quite dramatic in an asplenic individual with renal ...
Digitale Posterpräsentation der Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie im Rahmen des DACH-Kongress 2015.
Please do not use our site to attempt to diagnose or treat your pet. Your veterinarian is the best source of health advice for an individual pet. Please do use our site to become better informed about the medical problems your pet may have. We will do our best to ensure that information presented is accurate and up-to-date. The most current information will be at the top of each page. Remember that veterinarians often disagree about the best treatments for pets. There are often several perfectly acceptable ways to treat the same condition. Just ask a lot of questions! For all emergency situations, please contact your local Emergency Pet Clinic or on-call Veterinarian. Answers are not provided in real time. We can not guarantee an answer to every question, nor can we provide timely responses to urgent questions in many instances. ...
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26 References Hoffman. Hematology: Basic Principles and Practices, 5 th ed. Hoffman. Hematology: Basic Principles and Practices, 5 th ed. Keane. Nadas Pediatric Cardiology. 2 nd ed. Keane. Nadas Pediatric Cardiology. 2 nd ed. UTDOL. Jan 2010. UTDOL. Jan 2010. Patient knowledge of the risks of post-splenectomy sepsis. ANZ J Surg. 2008 Oct;78(10):867-70. Patient knowledge of the risks of post-splenectomy sepsis. ANZ J Surg. 2008 Oct;78(10):867-70. Evaluation of severe infection and survival after splenectomy. Am J Med. 2006 Mar;119(3):276.1-7. Evaluation of severe infection and survival after splenectomy. Am J Med. 2006 Mar;119(3):276.1-7. ...
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
Infectious Disease is a chapter in the book, Gastroenterology, containing the following 23 pages: Diverticulitis, Spontaneous Bacterial Peritonitis, Campylobacter jejuni, Vibrio Cholera, Clostridium difficile, Escherichia coli, Salmonella, Typhoid Fever, Shigella, Yersinia enterocolitica, Entamoeba histolytica, Cryptosporidium parvum, Giardia lamblia, Norovirus, Rotavirus, Liver Abscess, Pancreatic Abscess, Helicobacter Pylori, Overwhelming Postsplenectomy Infection, Viral Gastroenteritis, Listeria monocytogenes, Enterohemorrhagic E. coli, Cyclospora.
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Splenectomy: For decades, surgical splenectomy was the treatment of choice; however, recent data suggest that less than 30% of patients with ITP undergo splenectomy [32], despite long-term response rates of 60-70% [3334]. Risk of infection (5- to 30-fold increase in the first 90 days and 1- to 3-fold life-long increased risk of invasive bacterial infection and sepsis), risk of thrombosis (,30-fold compared to the general population) as well as reports of pulmonary hypertension and immediate post-operative complications may have contributed to decreased splenectomy rates [343536]. Therefore, it is recommended to delay splenectomy for at least 6 months to one year after diagnosis even if splenectomy is considered as a useful second-line treatment [3].. According to the 1996 and 2011 ASH guidelines, further treatment of patients, with platelet counts ,30×109/L in the absence of bleeding who have failed to respond to splenectomy, is not recommended. However, further treatment was recommended for ...
Patients for elective splenectomy are usually referred to the surgeon by hematologists or oncologists, because their treatment with blood products, corticosteroids, plasmaphoresis, gamma globulins, or chemotherapy can no longer safely control the primary disease. Accordingly, the patient may require transfusion of blood products to raise the hematocrit or platelet counts to safe levels for general anesthesia and coagulation during surgery. Packed red cells may be given in advance of planned surgery, whereas platelets, with their short life span, may be infused just prior to and during the procedure. When platelet transfusions are contraindicated, endogenous platelet counts are often temporarily boosted with a few days of increased corticosteroid therapy, immune globulin or Rho D immune globulin (winrho) prior to surgery. If steroids are used, then they must be continued during and immediately after surgery. The patient should have a type and screening blood test, and blood products must be ...
Our studies give evidence of increase in the iron elimination in three of five dogs during a period of two weeks following splenectomy, but not in two other dogs. The occasional increased output of iron may have some relation to the anemia which occurs in the early weeks after splenectomy and which varies in degree in different animals.. No evidence was secured of an increase in the iron output at 1, 9, and 20 months after splenectomy.. From our own studies and from examination of the literature of the subject, we conclude that the spleen does not exercise a constant and important influence upon the iron metabolism of the body.. ...
Thrombocytopenia cases that are particularly resistant may require surgery called splenectomy, where the doctor removes the spleen from the body. Although the function of the spleen is not 100% understood, researchers show that it functions as a filter for the blood, and removes old red blood cells and platelets from the blood stream.. In some cases, the spleen becomes enlarged and stores more than the normal amount of what should only be taken from circulating platelets. This leads to thrombocytopenia. A splenectomy surgery is usually the most preferable low platelet count treatment option to cure the dysfunction; but, doctors generally tries first to use more conservative treatment options, considering that there is no way to undo splenectomy.. On average, splenectomies are successful for about 66 percent of the time. But, over time, it is still possible for thrombocytopenia to recur. People younger than 40 who have undergone splenectomy have a better chance to increase their number of ...
A splenectomy is the procedure done to remove the spleen. Before effective drugs became available for hairy cell leukemia, splenectomy was the first-line treatment for the disease.
TY - JOUR. T1 - Successful rescue of refractory, severe antibody mediated rejection with splenectomy. AU - Kaplan, Bruce. AU - Gangemi, Antonio. AU - Thielke, James. AU - Oberholzer, José. AU - Sankary, Howard. AU - Benedetti, Enrico. PY - 2007/1. Y1 - 2007/1. N2 - Antibody-mediated rejection (AMR) commonly occurs after transplantation of ABO-incompatible and sensitized renal transplant. Treatment regimens commonly include a combination of plasmapheresis (PL) and intravenous immunoglobulin (IVIG). However, some cases of AMR remain refractory to treatment. We report a case series of four patients with AMR refractory to standard therapy (ST) who resolved after splenectomy. Four living donor kidney transplant recipients were diagnosed with AMR. Two patients were ABO incompatible, one was cross-match positive and one had no obvious predisposing factors. After failure of therapy with corticosteroids, PL, IVIG, Thymoglobulin, and Rituximab (three patients) or Campath (one patient), AMR was treated ...
At the time of the publication of the guidelines (2010-2011), there were little data available on the long-term safety and efficacy of many second-line therapies for ITP, in particular, for the TPO-RA. In part because of this, splenectomy was recommended in the ASH guidelines as second-line therapy for ITP with the recommendation to try to delay splenectomy to 6 months to 1 year after diagnosis.3 The International Consensus group on ITP listed additional alternatives to splenectomy as acceptable second-line therapies, however.4 For decades, surgical splenectomy was the treatment of choice; however, recent data suggest that ,25% of patients with ITP undergo splenectomy,64 despite 5-year response rates of 60% to 70%.65,66 Risk of infection (5- to 30-fold increase in the first 90 days and 1- to 3-fold life-long increased risk of invasive bacterial infection and sepsis), risk of thrombosis (,30-fold compared with the general population), as well as reports of pulmonary hypertension and immediate ...
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With acquisition of an ever increasing number of more or less specific therapeutic agents, splenectomy in leukemia has been performed infrequently in more recent years. There remains, however, a small group of leukemic patients who may be substantially benefited by splenectomy.. The result of splenectomy in 34 new patients is presented with a critical review of results obtained in a total of 299 cases collected from the literature.. The criteria for splenectomy in leukemia and myelofibrosis are: (a) Ineffectiveness of other forms of therapy to control cytopenia, particularly anemia in the presence of a splenomegaly when the anemia, or cytopenia in general, is sufficiently severe to be a major element of illness. In such a state, splenectomy must be conditioned on evidence, by study of the bone marrow and by determination of the rate of turnover of red cells, that the production of red cells is at least normal, preferably if it is increased. (b) Intractable pain, referable to the size of the ...
Survival of patients with myelofibrosis who undergo splenectomy is adversely affected by older age, the need for transfusion, and leukocyte and circulating blast cell counts, according to a new analysis. 1
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Autologous splenic transplantation in post-traumatic splenectomy - Minerva Chirurgica 1999 January-February;54(1-2):31-6 - Minerva Medica - Journals
Stolfi, R L.; Stolfi, L M.; Fugmann, R A.; and Martin, D S., Augmented therapeutic results elicited by splenectomy in combined modality treatment of spontaneous murine breast cancer. (1977). Subject Strain Bibliography 1977. 1065 ...
Your surgeon or dermatologist cialis cheap Find. And Russia cheap Find cialis for medical advice. A single polyp found during laparoscopic splenectomy are usually caused by repetitive stress injuries.
Patients require at least 14 days to become fully immu- Splenic preservation is feasible in select patients with nized against encapsulated organisms (Streptococcus pneu- benign tumors order 100 mg epitol overnight delivery, small neuroendocrine tumors buy epitol 100 mg mastercard, or cystic neo- moniae cheap epitol 100 mg with visa, Haemophilus influenza type B, and Neisseria plasms without proximity or invasion of the spleen paren- chyma. Recent reports indicate that splenic preservation with division of the splenic artery and vein is safe in select patients. Also, if bleeding were Department of Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Dr. Port placement will be variable depending on should also have an open tray of instruments available for the patients body habitus. Once a camera is placed in the supraumbilical location, a secondary port is placed to allow General Considerations for exposure of the undersurface of the liver and palpation of any suspicious lesions. ...
TY - JOUR. T1 - Clinical and Hematologic Benefits of Partial Splenectomy for Congenital Hemolytic Anemias in Children. AU - Rice, Henry E.. AU - Oldham, Keith T.. AU - Hillery, Cheryl A.. AU - Skinner, Michael A.. AU - OHara, Sara M.. AU - Ware, Russell E.. PY - 2003/2. Y1 - 2003/2. N2 - Objective: To assess the role of partial splenectomy for symptomatic children with various congenital hemolytic anemias. Summary Background Data: The use of total splenectomy for symptomatic children with congenital hemolytic anemias is restricted by concern of postsplenectomy sepsis. A partial splenectomy is an alternative procedure, although its utility remains incompletely defined. Methods: This longitudinal cohort study followed 25 symptomatic children with various congenital anemias who underwent partial splenectomy. Sixteen children had hereditary spherocytosis (HS), and nine children had other erythrocyte disorders. Outcome measures were clinical and laboratory hemolysis, splenic phagocytic and immune ...
TY - JOUR. T1 - Massive hepatomegaly following splenectomy for myeloid metaplasia. AU - Grieco, Antonio. AU - Gambassi, Giovanni. AU - Manna, Raffaele. AU - Mancini, Rosalba. PY - 1988. Y1 - 1988. N2 - no abstract. AB - no abstract. KW - hepatomegaly. KW - myeloid metaplasia. KW - hepatomegaly. KW - myeloid metaplasia. UR - http://hdl.handle.net/10807/20968. M3 - Article. VL - 84. SP - 797. EP - 798. JO - American Journal of Medicine. JF - American Journal of Medicine. SN - 0002-9343. ER - ...
To the Editor.-A recent article1 on the incidence of residual splenic tissue following splenectomy for trauma described a 26% occurrence of splenosis. This is a
TY - JOUR. T1 - Palliative splenectomy in myelofibrosis with myeloid metaplasia. AU - Mesa, R. A.. AU - Tefferi, A.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Myelofibrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder in which the accumulation and growth of circulating myeloid progenitors in the spleen lead to pathologic enlargement of the organ with resulting mechanical discomfort, hypercatabolic symptoms, anemia, thrombocytopenia, and portal hypertension. Medical therapy and splenic irradiation may be of benefit in certain patients, yet many may still require splenectomy to palliate their symptoms. Although there is no clear survival advantage to splenectomy in MMM, the procedure can result in substantial palliation of symptoms. However, the surgical procedure is associated with an approximately 9% mortality rate, and the postsplenectomy occurrence of extreme thrombocytosis, hepatomegaly, and leukemic transformation is of major concern. The management of splenomegaly and the ...
Splenectomy is part of the therapeutic arsenal in those hematological diseases where the spleen constitutes the predominant organ of destruction of the formed elements of the blood; in most cases, they are patients with immune thrombocytopenic purpura and hereditary spherocytosis. Sutherland, in 1910 it was he who first proposed splenectomy in the treatment of hereditary spherocytosis and Kuznelson in 1916 for thrombocytopenic purpura . From the first laparoscopic cholecystectomy performed in 1985 and after it became the gold standard for the treatment of gallstones.from the nineties on; The development of videolaparoscopic surgery has been rapid in the last decade. As the number of procedures performed increased, the experience of the surgeons also increased, and with it, the acquisition of the necessary training to perform other procedures of greater complexity (advanced laparoscopic surgery). Laparoscopic splenectomy was first performed in 1991 by Delaitre and Maignien and has gained ...
Laparoscopic splenectomy is widely accepted as a preferred surgical technique. Single port laparoscopic surgery further improves cosmesis, pain control and recovery compared to standard multi-port laparoscopy.. We report on a single port accessory splenectomy in patient with symptomatic recurrence of autoimmune hemolytic anemia after prior splenectomy more that 30 years ago. Patient was maintained on prednisone 30 mg daily preoperatively. Preoperative imaging localized accessory spleen to left upper quadrant area. With the use of SILS™ Port (Covidien) accessory spleen was identified in splenic fossa and removed. The later represented globular mass of 35 grams, 4.6 x 4.3 cm in diameter. Procedure lasted 80 minutes. Estimated blood loss was 30 ml. Postoperatively patient did well and was discharged on postoperative day three requiring only four Lortab tablets during hospital stay. During follow up patient is doing well, currently off steroids with hematocrit stabilized at 34 per cent.. We ...
The asplenic state is a health risk increasingly being recognised by health professionals all over the world. Infection in patients with an absent or dysfunctional spleen remains largely preventable. Many measures have been proposed to reduce the risk of sepsis after splenectomy, which include chemoprophylaxis, immunoprophylaxis, and patient/clinician education.6. Other than the known susceptibility of splenectomised individuals to encapsulated bacteria (Streptococcus pneumoniae, N meningitides, and H influenziae),7 there is evidence to suggest that other organisms, such as Gram negative bacteria and Capnocytophaga canimorsus,2 in addition to intraerythrocytic parasites, such as babesia and plasmodium, can cause infections and carry considerable morbidity.8. The pneumococcal vaccine, first introduced in the 1970s, presently includes 23 serotypes responsible for approximately 88% of pneumococcal infections. However, the most virulent pneumococcal serotypes tend to be the least immunogenic, and ...
TY - JOUR. T1 - Spleen-preserving lymphadenectomy versus splenectomy in laparoscopic total gastrectomy for advanced gastric cancer. AU - Son, Sang Yong. AU - Shin, Dong Joon. AU - Park, Young Suk. AU - Oo, Aung Myint. AU - Jung, Do Hyun. AU - Lee, Chang Min. AU - Ahn, Sang Hoon. AU - Park, Do Joong. AU - Kim, Hyung Ho. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Background To investigate the optimal approach for laparoscopic splenic hilum lymph node dissection in proximal advanced gastric cancer, we compared the operative outcomes between laparoscopic spleen-preserving total gastrectomy (sp-LTG) and laparoscopic total gastrectomy with splenectomy (sr-LTG). Methods A retrospective case-cohort study was conducted between February 2006 and December 2012. The operative outcomes, the number of retrieved splenic hilum lymph node, complication, and patients survivals were analyzed. Results 112 patients who underwent laparoscopic total gastrectomy with or without splenectomy for advanced gastric cancer were ...
The splenomegaly associated with myelofibrosis and agnogenic myeloid metaplasia should not be considered a manifestation of the fundamental proliferative process, nor should it be considered as necessarily compensatory for reduced marrow haematopoiesis.. In deserving cases splenectomy may cause an improvement in the patients general and haematopoietic status. Removal of the source of functional hypersplenism, causing haemolytic episodes and thrombocytopenia, results in marked amelioration in the clinical condition with reduction in the magnitude and frequency of replacement blood transfusion.. The massive size of the spleen associated with this condition may not only cause local pain and discomfort but may lead to traumatic or spontaneous rupture.. Consideration of two cases studied by the authors indicates that marked clinical improvement may be associated with splenectomy in selected cases of agnogenic myeloid metaplasia.. ...
Background: In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial infections associated with splenectomy is well known. Recently, hypercoagulation disorders have also been linked to splenectomy through loss of regulation of platelet activity, loss of filtering function and post-splenectomy thrombocytosis.. Case presentation: A 28 year-old smoking women who had previously undergone splenectomy due to hereditary spherocytosis with a moderate thrombocytosis (platelet count 553-635*109/L), presented with recurrent episodes of pulmonary embolisms. Further examination by multimodality cardiac imaging demonstrated a giant chronic thrombus in the right ventricular outflow tract, which eventually had to be surgically removed.. Conclusions: The present case highlights the increased risk of severe thromboembolic complications following therapeutic ...
The laparoscopic intra-operative findings were splenic infarction, abscess in the lower part of the spleen and widespread inflammatory adhesions between spleen, greater omentum and parietal peritoneum. We performed laparoscopic splenectomy using Ligasure as device for dissection and vessels sealing. The estimated blood loss was 230 mL. The postoperative course was uneventful, no blood transfusion was needed and the patient was discharged on the 12th postoperative day. Histopathological examination confirmed infarction of the spleen and the presence of multiple abscesses. ...
The laparoscopic approach in distal pancreatectomy is associated with higher rates of splenic preservation compared to open surgery. Although favorable pos
Purpose: The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). Methods: The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy. Results: The analysis included 130 children, with 62.3% (n = 81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1 g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p , 0.001). For children with SCD, there was no change in hemoglobin. Laparoscopy was not associated with differences ...
Abstract. Objective: Although the anterior approach is normally used for elective laparoscopic splenectomy (LS), the posterolateral approach may be superior. We have retrospectively compared the effectiveness and safety of these approaches in patients with non-severe splenomegaly scheduled for elective total LS.. Methods: Patients with surgical spleen disorders scheduled for elective LS between March 2005 and June 2011 underwent laparoscopic splenic mobilization via the posterolateral or anterior approach. Main outcome measures included operation time, intraoperative blood loss, frequency of postoperative pancreatic leakage, and length of hospital stay.. Results: During the study period, 203 patients underwent LS, 58 (28.6%) via the posterolateral and 145 (71.4%) via the anterior approach. Three patients (1.5%) required conversion to laparotomy due to extensive perisplenic adhesions. The posterolateral approach was associated with significantly shorter operation time (65.0 ± 12.3 min vs. 95.0 ...
A child may be asplenic for anatomic or functional reasons. Anatomic reasons include: (1) congenital asplenia, which can be isolated, or part of Ivemark syndrome, which is associated with cardiovascular defects and heterotaxy and (2) splenectomy. Splenectomy may be performed for various reasons. In children, the most common reasons are trauma-associated splenic rupture, malignancy, hypersplenism, and splenomegaly associated with persistent anemia and/or thrombocytopenia.2 Functional asplenia results from having an anatomically intact but poorly working spleen. There are various conditions that can cause functional asplenia, including sickle cell disease (Table 57-1). Some of the mechanisms leading to functional asplenia include infarction, infiltration, and impaired phagocyte function.2-4 ...
BOF: 139. A patient who is known to have hereditary spherocytosis and has mild jaundice and gallstones is awaiting splenectomy. In this patient you would like to make sure that Pneumococcal immunisation is administered:. a) 24 hours prior to splenectomy. b) 2-3 weeks prior to splenectomy. c) 2-3 months prior to splenectomy. d) 72 hours prior to splenectomy. e) 6 weeks prior to splenectomy. ...
BILIARY TRACT. Laparoscopic cholecystectomy. Open cholecystectomy. CBD exploration. Choledochoduodenostomy. Hepatico jejunostomy for biliary stricture. Choledochal cyst excision Extended cholecystectomy for carcinoma gallbladder. Liver resections for Cholangiocarcinoma. PANCREAS. Pancreatic necrosectomy for acute pancreatitis. Freys procedure for chronic pancreatitis. Lateral pancreaticojejunostomy for chronic pancreatitis. Cystogastrostomy. Cystojejunostomy. Whipples procedure for pancreatic cancer. Central pancreatectomy. Distal pancreatectomy. Surgery for pancreatic trauma. SPLEEN. Laparoscopic splenectomy. Open splenectomy. Surgery for splenic trauma. LIVER. Surgery for hydatid cyst. Deroofing of liver cyst. Hepatectomy for liver tumors. Debridement of liver abscess. Surgery for liver trauma. PORTAL HYPERTENSION. Proximal splenorenal shunt. Distal splenorenal shunt. Side to side splenorenal shunt. Mesocaval shunt. Devascularisation. Splenectomy. ESOPHAGUS. Emergency management of corrosive ...
TY - JOUR. T1 - Permanent large granular lymphocytosis in the blood of splenectomized individuals without concomitant increase of in vitro natural killer cell cytotoxicity. AU - Kelemen, E.. AU - Gergely, P.. AU - Lehoczky, D.. AU - Triska, E.. AU - Demeter, J.. AU - Vargha, P.. PY - 1986. Y1 - 1986. N2 - Increased numbers of circulating lymphocytes and large granular lymphocytes (LGL) were observed in 115 individuals splenectomized for haematological disease (74 cases) or for trauma (41 cases). LGL lymphocytosis was present in 78.4% of haematologically indicated and in 85.4% of traumatic splenectomies. A 70.5% of these values was above the 97.5 percentile upper tolerance limit of healthy controls (200 cases). In addition, 175 haematological controls were investigated. Forty per cent or more of circulating lymphocytes exhibited LGL morphology in nearly half of repeatedly investigated splenectomized persons. The increase in LGL is not attributable to lymphocytosis. It becomes apparent, and ...
Asplenic individuals are susceptible for overwhelming infection with Streptococcus pneumoniae, carrying a high mortality. Although Toll-like receptor (TLR)-2 is considered the major receptor for Gram-positive bacteria in innate immunity, it does not play a major role in host defense against pneumococcal pneumonia. We wanted to investigate if in absence of an intact spleen as a first line of defense, the role of TLR2 during pneumococcal pneumonia becomes more significant, thereby explaining its insignificant role during infections in immune competent hosts. We intranasally infected splenectomized wildtype (WT), TLR2 knock-out (KO) and TLR2/4 double KO mice with either serotype 2 or 3 S. pneumoniae. There were no differences between asplenic WT and TLR2KO mice of bacterial loads in lung homogenates and blood, cytokine and chemokine levels in the lungs, and lung pathology scores. TLR2/4 double KO mice were not impaired in bacterial control as well, which indicates that besides the interaction between S.
Today the surgeons performed the Laparoscopic splenectomy using the lateral Approach. The anterior approach is not used much these days.  Dissection for a ...
Hypersplenism is a disorder that causes the spleen to rapidly and prematurelydestroy blood cells.. The spleen is located in the upper left area of the abdomen. One of its majorfunctions is to remove blood cells from the bodys bloodstream. In hypersplenism, the spleens normal function accelerates, and it begins to remove cellsthat may still be normal in function. Sometimes, the spleen will temporarilyhold onto up to 90% of the bodys platelets and 45% of the red blood cells.Hypersplenism may occur as a primary disease, leading to other complications,or as a secondary disease, resulting from an underlying disease or disorder.Hypersplenism is sometimes referred to as enlarged spleen (splenomegaly). Anenlarged spleen is one of the symptoms of hypersplenism. What differentiateshypersplenism is its premature destruction of blood cells.. Hypersplenism may be caused by a variety of disorders. Sometimes, it is brought on by a problem within the spleen itself and is referred to as primary hypersplenism. ...
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Current guidelines recommend glucocorticoids and splenectomy as standard 1(st) and 2(nd) line treatments for chronic immune thrombocytopenia (ITP). We sought to find out how German ITP-patients are treated with respect to these guidelines. Members of a patient support association ≥18 years with a self-reported history of chronic ITP,12 months were surveyed with a web-based questionnaire. 122 questionnaires were evaluated. 70% of patients had chronic ITP for more than 5 years and 20% an average platelet count of ≤30·10(9)/L. 41% of the patients reported haematomas or petechiae more than once or twice and up to 12 times or more per year and 17% oropharyngeal and nasal bleeds. 11% had been admitted to hospital during the last 12 months. 88% had received or currently receive glucocorticoids, 27% were splenectomised. IVIG had been given to 55%, rituximab to 22%, anti-D to 12%, ciclosporin to 7%, while complementary and alternative medical treatments had been used by 36%. 50 women responded to ...
Background: This study was designed to perform serial assessment of alterations in platelet (PLT) count, morphology and biochemical markers of PLT activation during storage of platelet concentrates (PCs) and to correlate morphological changes with these activation markers. Materials and Methods: Our study included the platelet-rich plasma (PRP)-PC and buffy coat reduced PC (BC-PC) prepared from whole blood (WB) donations and the apheresis platelets (AP-PC). Routinely evaluated in vitro PLT parameters were followed. Morphology score (MS) was performed using the light microscopy, glucose and lactate concentration and soluble P-selectin (sP-selectin) level were determined using commercial kits. Results: The fall in mean pH from day 0 to the last day of storage was significant (P , 0.001) in all the groups. Glucose utilization was less in PRP-PC prepared from WB donations at Blood Donation Centre [PRP-PC (BDC)] when compared to PRP-PC prepared from WB donations at mobile blood drives [PRP-PC (M)] ...
TY - JOUR. T1 - A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model. AU - Yamaguchi, Y.. AU - Halperin, E. C.. AU - Harland, R. C.. AU - Wyble, C.. AU - Bollinger, R. R.. PY - 1989/12/1. Y1 - 1989/12/1. UR - http://www.scopus.com/inward/record.url?scp=0024909116&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024909116&partnerID=8YFLogxK. M3 - Article. C2 - 2662528. AN - SCOPUS:0024909116. VL - 21. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 3. ER - ...
This page includes the following topics and synonyms: Asplenic, Asplenia, Functional Asplenia, Asplenism, Hyposplenism, Hyposplenic, Postsplenectomy.
The effect of Nembutal on the circulating and tissue blood volumes and hematocrits was calculated by means of independent determinations of plasma and red cell volumes. Nembutal produced an increase in circulating blood volume accompanied by a reduction in the venous hematocrit. The blood volumes of liver, kidney, spleen and intestine rose following the administration of Nembutal, while the hematocrits of liver, lung, intestine and muscle declined, and that of kidney rose. The administration of Nembutal to splenectomized mice produces similar changes. The relationship of these alterations to changes in periphero-vascular tone are discussed.. ...
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OBJECTIVE: To investigate the role and mechanism of splenic myeloid-derived suppressor cells (MDSCs) in sepsis-induced adrenal injury (SAI). METHODS: Thirty male C57 mice aged 6-8 weeks were randomly divided into normal control group (n = 5), sham operation group (Sham group, n = 5), sepsis model group [cecal ligation and perforation (CLP) group, n = 10] and sepsis+splenectomy group (CLPS group, n = 10). The sepsis model of mice was reproduced by CLP method. In Sham group, only the cecum was opened and separated, then closed, without CLP. In CLPS group, the spleen was removed before CLP. In normal control group, no challenge was given. After 24 hours, the rats were sacrificed by anesthesia, and peripheral blood, spleen, bone marrow, and bilateral adrenal glands were harvested. The pathological of adrenal gland was assessed by hematoxylin-eosin (HE) staining under optical microscope. The ratio of MDSCs in peripheral blood, spleen and bone marrow was determined by flow cytometry. The expressions ...
From the question on page 395 Clinical and CT findings suggested a differential diagnosis between pleural metastasis and splenosis. Histopathology revealed normal splenic tissue, allowing the diagnosis of pleural splenosis.. Thoracic splenosis (TS) is a benign acquired condition involving the autotransplantation of splenic tissue into the pleural cavity. It frequently results from left upper abdominal trauma with concomitant splenic damage and left diaphragmatic tear. Splenic tissue gains access to the left pleural space and derives its blood supply from the pleura, chest wall or diaphragm. TS is usually asymptomatic and found incidentally by imaging examinations performed for other reasons. It rarely causes chest pain or haemoptysis.1-5 The average interval between trauma and TS diagnosis is ∼20 years.. Splenic implants are sessile or pedunculated reddish-blue nodules of normal splenic tissue with diameters ranging from a few millimetres to several centimetres.2 They may occur on the parietal ...
ejgm71760, journal = {European Journal of General Medicine}, issn = {1304-3889}, address = {Sağlık Bilimleri Araştırmaları Derneği}, year = {2015}, volume = {9}, pages = {33 - 35}, doi = {}, title = {LAPAROSCOPİC SPLENECTOMY FOR SPLENIC CYST HYDATIC; CASE REPORT}, language = {en}, key = {cite}, author = {SÖZEN, SELİM and ÖZDAŞ, SABRİ and AKDOĞAN, NEVZAT and AZİRET, MEHMET} } @ { ejgm71760, journal = {European Journal of General Medicine}, issn = {1304-3889}, address = {Sağlık Bilimleri Araştırmaları Derneği}, year = {2015}, volume = {9}, pages = {33 - 35}, doi = {}, title = {LAPAROSCOPİC SPLENECTOMY FOR SPLENIC CYST HYDATIC; CASE REPORT}, language = {tr}, key = {cite}, author = {SÖZEN, SELİM and ÖZDAŞ, SABRİ and AKDOĞAN, NEVZAT and AZİRET, MEHMET ...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
In doing elective open splenectomy, I liked to wear a headlight. It gets dark up there behind the ribs. Delivering the spleen into the midline, light isnt a problem. Its in the cleaning up after: that empty space where the spleen used to be is high up and back there a ways. Getting it up and out involves dividing the filmy but firm attachments between the lateral surfaces of the spleen and the peritoneal gutter in which it lies. In a dry field, it may be done sharply: long-handled scissors, or extended-length cautery with a nice bend in the tip. When the area is full of blood, you tend to do it dickless (in the sense of not dicking around. And what the heck, this is already an NC-17 blog, right?) Reach in -- in large people, it can be up to the elbow -- paddle the spleen with your fingers, like playing a sticky piano, to sense how bad it is; diggle your fingertips into the peritoneal attachments until it breaks free. Once the spleen is out, one of my favorite -- if simple -- maneuvers is the ...
Patients with primary immune thrombocytopenia (ITP) may require treatment to reduce the risk of serious bleeding if platelets remain consistently below 30 × 109/L. While approximately 70-80% of patien
As we all know, for malignant tumors, contrast CT imaging often shows quick-in and quick-out property. The abdominal masses of this patient were diagnosed as malignant tumors by contrast CT imaging because at artery phase the density of mass margin increased quickly while at venous phase the density decreased quickly, which shows the characteristic of malignant tumors. Therefore, we performed the operation. Unfortunately, finally we recognized that we misdiagnosed the disease which was actually ectopic spleen tissues.. As a matter of fact, we did not realize this disease prior to operation because we never heard of it. As a result, we performed the operation, and we figured out actually the tumors of liver and colon were spleen tissues. Then we reviewed some literatures, and acquired that this condition is splenosis, which often occurs in patients who ever underwent splenectomy7,8.. Intraabdominal splenosis is a generally asymptomatic entity incidentally diagnosed after the completion of CT scan ...
Laparoscopic splenectomy is done using an instrument called a laparoscope. This is a slender tool with a light and camera on the end. The surgeon makes three or four small cuts in your abdomen, and inserts the laparoscope through one of them. This allows the doctor to look into the abdominal area and locate your spleen. Different medical instruments are passed through the other openings. One of them is used to deliver carbon dioxide gas into your abdominal area, which pushes nearby organs out of the way and gives your surgeon more room to work. The surgeon disconnects the spleen from surrounding structures and the bodys blood supply, and then removes it through the largest surgical opening. The surgical openings are closed using stitches or sutures ...
It could be speculated that different pathological mechanisms underlie widespread significant brain perfusion decrements in temporal, parietal and frontal regions. Otherwise, a standard radical surgery is still tadalafil price the treatment of choice. To determine the prevalence and characters of tadalafil generic anomalous coronary artery, including the associations of myocardial ischemia. Because of 75 years of apartheid, the new government is faced with a formidable array of problems, both in health care and in the economic domain.. Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype. Preparation, characterization and biological evaluation of cationic 99Tc/99mTc-dioxime complexes. Evaluation of an automatic measuring device for determining certain constituents tadalafil 20mg lowest price of the urinary status The real value lies in use of data for program planning, resource allocation, program design, and evaluation. This is the first ...
Dr. Hoepfner responded: Exercise. Usually after you have healed, gradual return to full activities and exercises will usually improve your abdominal muscles. Walking, |a href=/topics/bicycling track_data={
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3) Under the best circumstances, if no further treatment is possible Mr. Jobs will suffer from progressive liver failure slip off into a painless coma and not wake up. That was the condition he was approaching when the first transplantation was done. Depending on the amount of liver function that he has left this time can be estimated from weeks to months although without some new treatment, and based solely on statistical data, I would be surprised but not amazed to find that he made it to the end of the year. It all really depends on how rapid the tumors in his liver, & elsewhere grow and impair his functioning. What I have been waiting for, fearfully, was that he would suffer a catastrophic complication of his treatment, i.e. rapid liver failure due to ischemia of the liver, overwhelming infection as a result of the immunosuppression needed to prevent rejection of his transplanted liver and would die unexpectedly in a spectacular fashion (Sorry if that sounds callous but thats what we ...
3) Under the best circumstances, if no further treatment is possible Mr. Jobs will suffer from progressive liver failure slip off into a painless coma and not wake up. That was the condition he was approaching when the first transplantation was done. Depending on the amount of liver function that he has left this time can be estimated from weeks to months although without some new treatment, and based solely on statistical data, I would be surprised but not amazed to find that he made it to the end of the year. It all really depends on how rapid the tumors in his liver, & elsewhere grow and impair his functioning. What I have been waiting for, fearfully, was that he would suffer a catastrophic complication of his treatment, i.e. rapid liver failure due to ischemia of the liver, overwhelming infection as a result of the immunosuppression needed to prevent rejection of his transplanted liver and would die unexpectedly in a spectacular fashion (Sorry if that sounds callous but thats what we ...
Causes of multiple organ failure - Help docs! Im trying to find out what causes multiple organ failure? Low blood supply. Low blood supply to the body will cause all organs to malfunction and fail if not corrected. Low blood supply can be caused by heart failure, low blood volume (bleeding, dehydration) and overwhelming infection, among others.
If a youngish person is in good health, an urgent life-threatening situation is likely to be trauma or overwhelming infection, like meningitis. In either case, virtually everybody would do whatever they could. Otherwise healthy people can recover from devastating trauma, etc., and you will not know how it turns out until it does.. If a 20 year old gets leukemia they will be treated to the max initially because many leukemias have impressive cure rates. Now, if that person is now 23 and has relapsed multiple times and has failed 2 bone marrow transplants, the desire/will/ability to keep going will be an issue to discuss.. The problem with checklists is that they are…checklists, a list of things to go through by rote, not because you expect anything of usefulness. Now, I know fighter pilots have their checklists, and I imagine the consequences of missing something are great motivations to stay alert, but often a checklist means you can do it with your mind not really paying attention (mine ...
We next compared the relative contributions of the spleen and the bone marrow in response to MI by using mice in which only one of the two tissues can contribute monocytes. First, we evaluated Ccr2-/- mice, because the chemokine receptor mediates monocyte mobilization from the bone marrow (9, 21), but not from the spleen (table S4). The number of blood monocytes comparably increased-and the number of splenic monocytes comparably decreased-after MI in both wild-type and Ccr2-/- mice (Fig. 3E). The released monocytes in Ccr2-/- mice did not accumulate in the ischemic myocardium, because infiltration depends on the chemokine CCR2 [table S4 and (7)]. Second, we evaluated animals splenectomized by a procedure that preserves the bone marrow and blood monocyte pools (fig. S7). After MI, blood monocyte numbers increased in control, but not splenectomized, animals (Fig. 3F). Analysis of the ischemic myocardium revealed a massive influx of Ly-6Chigh monocytes in mice containing the spleen. However, this ...
Spleen disorders are mainly a danger when left unaddressed. Although you can survive having you spleen removed (called a splenectomy), you might not be able to survive the causes of spleen disorders. That is why it is important to make an appointment with your doctor if you feel you may have a spleen condition. The purpose and function of the spleen. The spleen is a bodily organ that rests in the left side of the abdominal cavity, between the 9th to 12th ribs. The spleens central purpose is to get rid of old red blood cells, although it also functions as reservoir for blood in case you suddenly need it due to some sort of trauma.
Early detection of problems which concern the spleen is highly critical because when these are just being left untreated, these may probably lead to life-threatening situations. The treatment for pain relating to the spleen would vary immensely depending on the underlying pathology. Before your physician would prescribe you a specific treatment, your exact condition must first be determined. For instance, when the splenic pain is primarily felt due to an underlying infection may entirely be treated with antibiotics. When for instance this is caused by the presence of tumor near the spleen, surgery, chemotherapy and other common ways of treating cancer may help palliate or perhaps treat the condition. However, when it is all due to a ruptured spleen, a splenectomy, which is the surgical removal of the spleen, may be indicated. This surgical procedure poses several risks though. Since the spleen has been already removed, the person this time becomes more susceptible to infections. Thus, vaccines ...
Hall, F. D.; Spencer, W. G. (1909). "Splenectomy for (?) Splenic Anæmia". Proceedings of the Royal Society of Medicine. 2 (Clin ...
New York, NY: McGraw-Hill Education "Splenectomy and Infection" (PDF). Splenectomy Trust. March 2002. Archived from the ... Following splenectomy due to splenic rupture from trauma or because of tumor After splenectomy with the goal of interfering ... "Splenectomy wallet card". HSC Public Health Agency. Belfast. Archived from the original on 2 August 2019. Retrieved 1 August ... This can lead to results similar to those seen in patients who have undergone a splenectomy e.g. becoming infected with ...
Juneja, S; Januszewicz, E; Wolf, M; Cooper, I (1995). "Post-splenectomy lymphocytosis". Clinical and Laboratory Haematology. 17 ... such as tuberculosis or brucellosis chronic lymphocytic leukemia acute lymphoblastic leukemia lymphoma post-splenectomy state ...
A splenectomy was performed. The chest wound, left lung, and diaphragm were all debrided and the wounds closed. Himmler ordered ...
A splenectomy is initially performed and is followed by devascularization of the distal esophagus through the diaphragm hiatus ... Splenectomy is then performed. The abdominal esophagus is devascularized from the stomach. The posterior gastric vagus nerve ... The abdominal operation consists of a splenectomy, devascularization of the abdominal esophagus and cardia, and a selective ... The procedure also involves a splenectomy. The operation was originally developed to treat bleeding esophageal varices ( ...
Casaccia, M; Palombo, D; Fornaro, R; Razzore, A; Soriero, D; Frascio, M (2018). "Laparoscopic "double-port" splenectomy. A new ...
Patients with thalassemia major are more inclined to have a splenectomy. The use of splenectomies have been declining in recent ... Splenectomy is also associated with increased risk of infections and increased morbidity due to vascular disease, as the spleen ... Those undergoing splenectomy should receive an appropriate pneumococcal vaccine at least 1 week (preferably 3 weeks) before the ... If it is unnecessary to remove the entire spleen a partial splenectomy may occur; this method preserves some of the immune ...
"Splenectomy Risks - Mayo Clinic". www.mayoclinic.org. Retrieved 2016-03-02. Brigden, Malcolm L. "Detection, Education and ... "Splenectomy Results - Mayo Clinic". www.mayoclinic.org. Retrieved 2016-03-03. "What Is the Spleen? Functions & Info , ... Lack of a spleen, called asplenia, can occur by autosplenectomy or the surgical counterpart, splenectomy. Asplenia can increase ... Di Sabatino, Antonio (April 6, 2011). "Post-splenectomy and hyposplenic states". Lancet. 378 (9785): 86-97. doi:10.1016/s0140- ...
A splenectomy (removal of the spleen) results in a greatly diminished frequency of memory B cells. A 28-year follow-up of 740 ... 1977). "Splenectomy and Subsequent Mortality in Veterans of the 1939-45 War". The Lancet. 310 (8029): 127-29. doi:10.1016/S0140 ... Splenosis is a condition where displaced pieces of splenic tissue (often following trauma or splenectomy) autotransplant in the ... Di Sabatino, A; Carsetti, R; Corazza, GR (Jul 2, 2011). "Post-splenectomy and hyposplenic states". Lancet. 378 (9785): 86-97. ...
His arm was broken and he suffered several internal injuries; he eventually underwent a splenectomy. While he was hospitalized ...
Treatment has traditionally been splenectomy. Splenectomy involves ligation of three splenic attachments (splenorenal ligament ... However, splenectomy is avoided if possible, particularly in children, to avoid the resulting permanent susceptibility to ... When surgery is needed, the spleen can be surgically repaired in a few cases, but splenectomy is still the primary surgical ... 2], Suah A, Williams B. Exploratory Laparotomy and Splenectomy for Ruptured Spleen Following Blunt Force Trauma. J Med Ins. ...
Splenectomy is curative when this occurs. HPP has been associated with a defect of the erythrocyte membrane protein spectrin ... Splenectomy is a possible treatment[citation needed] Erythrocyte Poikilocytosis List of hematologic conditions " ...
Splenectomy Accessory spleen or Polysplenia Wu; et al. (January 2011). "Graft-versus-host disease after intestinal and ... Splenic tissue can be deliberately autotransplanted after splenectomy, as some tissue will still be viable, to attempt to ...
If ineffective, splenectomy should be considered.[citation needed] If refractory to both these therapies, other options include ...
Poulin EC, Thibault C (October 1993). "The anatomical basis for laparoscopic splenectomy". Can J Surg. 36 (5): 484-8. PMID ... and the variations of suspensory ligament of the spleen it is essential in the case of open surgery or laparoscopic splenectomy ...
Unlike hereditary spherocytosis, splenectomy is contraindicated. Bruce LJ, Robinson HC, Guizouarn H, et al. (2005). "Monovalent ...
Splenectomy may improve neutropenia in severe disease. Use of rituximab and leflunomide have been proposed. Use of gold therapy ...
Patients with severe haemolytic anemia may require splenectomy. Hereditary elliptocytosis Sickle-cell disease List of ...
McBride JA, Dacie JV, Shapley R (February 1968). "The effect of splenectomy on the leucocyte count". British Journal of ...
He undergoes a splenectomy and makes a recovery. To celebrate Shane and Angel's first anniversary, the couple and Dylan take a ...
This abscess develops after surgical operations like splenectomy. Presents with cough, increased respiratory rate with shallow ...
Splenectomy is the surgical removal of the spleen. Autosplenectomy is where certain diseases destroy the spleen's function. ...
Splenectomy is unlikely to reduce B cell burden; peripheral blood B cell counts rose significantly in three patients who ...
Splenectomy may be warranted for persistent pseudocysts due to the high risk of subsequent rupture. Although it can occur ... It can also be used prior to splenectomy for the prevention of blood loss. Chapman, J; Bhimji, SS (2018), "article-29380", ... Surgical removal of the spleen (splenectomy) is only required if complications ensue; surgical removal predisposes to ... only seldom requires splenectomy. Case report and literature review". Ann Ital Chir. 78 (6): 529-32. PMID 18510036. Suzuki Y, ...
Nancy suffers internal bleeding and requires a splenectomy. The Chief of Staff at the hospital (who just happens to be Nancy's ...
Removal of the spleen (splenectomy) could theoretically help to reduce the need for blood transfusions in people with ... Sharma, A; Easow Mathew, M; Puri, L (17 September 2019). "Splenectomy for people with thalassaemia major or intermedia". The ...
... can also be caused by appendicitis and splenectomy. Primary neutrophilia can additionally be a result of leukocyte ...
Splenectomy is indicated for moderate to severe cases, but not mild cases. To decrease the risk of sepsis, post-splenectomy ... sepsis caused by encapsulated organisms is a possible complication of splenectomy. The option of partial splenectomy may be ... Treatment options include: Splenectomy: As in non-hereditary spherocytosis, acute symptoms of anemia and hyperbilirubinemia ... Partial splenectomy: Since the spleen is important for protecting against encapsulated organisms, ...
Splenectomy can produce long-term remissions in patients whose spleens seem to be heavily involved, but its success rate is ... Splenectomies are also performed for patients whose persistently enlarged spleens cause significant discomfort or in patients ... More than half of people respond partially to splenectomy. In terms of B-cell development, the prolymphocytes are less ...
A splenectomy or partial gastrectomy may also be required. A cystotomy is a surgical opening of the urinary bladder. It is ...
Splenectomy may also lead to chronic neutrophilia. Splenectomy patients typically have Howell-Jolly bodies and less commonly ... An increase in blood leukocytes can occur following a splenectomy. The post-splenectomy platelet count may rise to abnormally ... A splenectomy also results in a greatly diminished frequency of memory B cells. A 28-year follow-up of 740 World War II ... A splenectomy is the surgical procedure that partially or completely removes the spleen. The spleen acts as a blood filter. ...
An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following ... Most infections occur in the first few years following splenectomy, but the risk of OPSI is lifelong. OPSI is almost always ... Sinwar, Prabhu (December 2014). "Overwhelming post splenectomy infection syndrome - Review study". International Journal of ...
Splenectomy is used to treat a wide variety of diseases and conditions. Your doctor may recommend splenectomy if you have one ... Open splenectomy. During open splenectomy, the surgeon makes an incision in the middle of your abdomen and moves aside muscle ... Splenectomy is generally a safe procedure. But as with any surgery, splenectomy carries the potential risk of complications, ... Laparoscopic splenectomy. During laparoscopic splenectomy, the surgeon makes four small incisions in your abdomen. He or she ...
Splenectomy is the procedure performed to remove the spleen. It may be done for various indications, some of which are detailed ... Types of splenectomy. Splenectomy is performed in different ways:. *Open splenectomy using a midline or subcostal incision, ... Consequences of splenectomy. The spleen plays various roles in immunity and red cell recycling. As a result, splenectomy ... In most situations, total splenectomy is the rule. Partial splenectomy is performed only in certain specific conditions such as ...
Post-splenectomy complications can occur after surgery to remove the spleen. Complications may include: ... Splenectomy - post-surgery syndrome; Overwhelming post-splenectomy infection; OPSI; Splenectomy - reactive thrombocytosis ...
A splenectomy is surgery to remove an injured spleen. ... What Is a Splenectomy?. A splenectomy (splih-NEK-tuh-mee) is ... When Are Splenectomies Done?. To treat some spleen injuries and problems, doctors may do a splenectomy. For example:. *More ... What Happens During a Splenectomy?. A child will get general anesthesia before a splenectomy to sleep through the procedure and ... An open splenectomy is similar to laparoscopic surgery but requires a larger cut in the skin. Doctors might use this option if ...
Make research projects and school reports about Splenectomy easy with credible articles from our FREE, online encyclopedia and ... Splenectomy Gale Encyclopedia of Cancer COPYRIGHT 2002 The Gale Group Inc.. Splenectomy. Definition. Splenectomy is the ... Splenectomy Gale Encyclopedia of Medicine, 3rd ed. COPYRIGHT 2006 Thomson Gale. Splenectomy. Definition. Splenectomy is the ... Complete splenectomy REMOVAL OF ENLARGED SPLEEN. Splenectomy is performed under general anesthesia. The most common technique ...
Splenectomy is the surgical removal of the spleen. The spleen is an organ in the upper left part of the abdomen. It lies ... Cadili A, de Gara C. Complications of splenectomy. Am J Med. 2008;121(5):371-375. ... Splenectomy. The Cleveland Clinic website. Available at: https://my.clevelandclinic.org/health/articles/splenectomy-spleen- ...
Choosing Florida Hospital Tampa for Splenectomy. Florida Hospital Tampa is a trusted resource for a full range of medical ... Learn more about Splenectomy at Florida Hospital Tampa by contacting us below. ...
... and management of splenic injuries may require splenectomy or, rarely, splenorrhaphy. ... Background Open splenectomy is performed in two major clinical scenarios: trauma and hematologic disease. The spleen is one of ... Casaccia M, Sormani MP, Palombo D, Dellepiane C, Ibatici A. Laparoscopic Splenectomy Versus Open Splenectomy In Massive and ... Combined Laparoscopic Splenectomy and Esophagogastric Devascularization versus Open Splenectomy and Esophagogastric ...
Hand‐assisted laparoscopic splenectomy for sclerosing angiomatoid nodular transformation of the spleen complicated by chronic ... We also performed hand‐assisted laparoscopic splenectomy to ensure easy handling of the splenomegaly. The resected specimen ... Keywords: Disseminated intravascular coagulation; laparoscopic splenectomy; sclerosing angiomatoid nodular transformation ... angiomatoid nodular transformation with hemangiomatous features may cause coagulation disorders for which splenectomy should be ...
... The main point to remember is that if you ever become unwell with fever ... Although it used to be said that serious infection was more likely in the first two years after splenectomy, you need to ... Surgeons are sometimes forced to remove the spleen (splenectomy) to control the bleeding that results from its injury. ...
Post Splenectomy Diaphragmatic Hernia. Laura E Grimmer, MD, Michael L Brunt, MD. Washington University ... lateral diaphragmatic hernia occurring ten years after a difficult splenectomy for lymphoma. We performed a laparoscopic ...
Splenectomy is surgery to remove the spleen. The spleen gets rid of old and damaged red blood cells. Red blood cells may be ... Splenectomy. Topic Overview. Splenectomy is surgery to remove the spleen. The spleen gets rid of old and damaged red blood ...
... there has not yet been a single prospective randomized study to support any advantage of laparoscopic over open splenectomy (OS ... Since the first laparoscopic splenectomy (LS) performed by Delaître in 1991, numerous case series have shown the feasibility of ... Children requiring splenectomy for hematologic conditions differ from adults by a greater susceptibility to post-splenectomy ... Splenectomy for malignant hematologic diseases. Splenectomy for malignant diseases mostly is performed for diagnosis or staging ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
... robotic-assisted splenectomy, short gastrics, skeletonization, spleen, splenic flexure mobilization, splenic nodules, splenic ...
2006). Such comparison was not found in the literature in relation to splenectomy in dogs, although splenectomy is commonly ... Longer operative time observed in laparoscopic splen-ectomy when compared to conventional splenectomy was consistent with the ... Laparoscopic splenectomy. Surg. Endosc. 16:851-854. [ Links ]. Cerón J.J., Eckersall P.D. & Martinez-Subiela S. 2005. Acute ... Splenectomy in the dog by ligation of the splenic and short gastric arteries. Vet. Surg. 18:110-113. [ Links ]. ...
... Topic Overview. Splenectomy is surgery to remove the spleen. The spleen gets rid of old and damaged red blood ...
I want to live in India, but Ive had a splenectomy.. It would be wise to carry a warning card to alert health workers to your ... Following splenectomy you will be at increased risk of infection for the rest of your life. ... I had a splenectomy in 1980 and am now considering going to live in India. ...
... Heng-Xiao Wang,1 Shuang-Qin Yi,2 Jun Li,1 Hayato ... Heng-Xiao Wang, Shuang-Qin Yi, Jun Li, et al., "Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice," ...
... Heng-Xiao Wang,1 Shuang-Qin Yi,2 Jun Li,1 Hayato ... and 40 weeks old compared to aly/aly mice without splenectomy. This indicated that a splenectomy can suppress inflammation ... Immunohistological Changes after Splenectomy. In 20-week-old splenectomized aly/aly mice, a slight expression of CD4+ cells in ... Figure 2: Histopathological analysis of effects of splenectomy (sp) on pancreatitis developing in aly/aly mice at the ages of ...
Thromboembolism has been reported as a complication following splenectomy for various hereditary chronic hemolytic anemias … ... disease and chronic pulmonary hypertension in an adult patient with pyruvate kinase deficiency who underwent splenectomy as a ... Recurrent thromboembolic disease following splenectomy for pyruvate kinase deficiency Am J Hematol. 2001 Jul;67(3):197-9. doi: ... Our patient presented at age 37 with recurrent pulmonary emboli, 36 years after splenectomy for severe hemolytic anemia. Work- ...
The indication for splenectomy, age at the time of splenectomy, interval between splenectomy and diagnosis of CETPH, and ... Ideally, to address the relationship between splenectomy and CTEPH, a group of patients with splenectomy and no other ... The prevalence of splenectomy was calculated for both groups and the 95% confidence intervals were determined. The χ2 test was ... Five thousands splenectomies are performed every year in France.14 It can therefore be estimated that the prevalence of ...
Splenectomy - post-surgery syndrome; Overwhelming post-splenectomy infection; OPSI; Splenectomy - reactive thrombocytosis ... Post-splenectomy syndrome. Definition. Post-splenectomy syndrome can occur after surgery to remove the spleen. It consists of a ...
... who have undergone splenectomy that their natural defense against acute bacterial infection is decreased. Any fever, ... Splenectomy for immune thrombocytopenic purpura: surgery for the 21st century. Am J Hematol. 2008 Feb. 83(2):93-6. [Medline]. ... Laparoscopic splenectomy is a better treatment for adult ITP than steroids--it should be used earlier in patient management. ... Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet. 1977 Jul 16. 2(8029):127-9. [Medline]. ...
Procedure: Distal pancreatectomy with partial splenectomy Distal pancreatectomy with partial splenectomy. Other Name: ... Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors. The safety and scientific validity of this study is the ... Splenectomy results in measurable changes in the cellular components of the blood. If thrombocytosis occurs as a result of ... Splenectomy results in measurable changes in the cellular components of the blood. If thrombocytosis occurs as a result of ...
Although splenectomy has been employed for management of ITP in these patients, the possibility that splenectomy may worsen an ... Splenectomy was not associated with mortality in another cohort of 473 patients with CVID, of which 39 underwent splenectomy ... Safety of splenectomy. Complications associated with splenectomy can be divided into perioperative/short-term and long-term ... Rituximab can delay the need for splenectomy,85 and many would advocate a trial of rituximab before splenectomy or TPO-RA ...
To study the safety and efficacy of Laparoscopic Splenectomy (LS) for Immune Thrombocytopenic Purpura (ITP). MATERIAL AND ... Splenectomy / adverse effects, methods*. Surgical Procedures, Elective. Treatment Outcome. From MEDLINE®/PubMed®, a database of ... OBJECTIVE: To study the safety and efficacy of Laparoscopic Splenectomy (LS) for Immune Thrombocytopenic Purpura (ITP). ... 16865623 - Predictive factors for successful laparoscopic splenectomy in immune thrombocytopenic p.... 10442593 - The role of ...
A splenectomy (say splih-NEK-tuh-mee) is surgery to take out the spleen. You may have your spleen taken out because a disease ... Splenectomy. Surgery Overview. A splenectomy (say "splih-NEK-tuh-mee") is surgery to take out the spleen. You may have your ...
  • Open splenectomy using a midline or subcostal incision, depending on the need of the surgeon's need for exposure of the organ, and the etiology. (news-medical.net)
  • An open splenectomy is similar to laparoscopic surgery but requires a larger cut in the skin. (kidshealth.org)
  • Before open splenectomy, a Foley catheter should be placed. (medscape.com)
  • Open splenectomy requires a laparotomy set with abdominal retractors and good lighting. (medscape.com)
  • Chen J, Ma R, Yang S, Lin S, He S, Cai X. Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases: a meta-analysis. (medscape.com)
  • Hassan ME, Al Ali K. Massive splenomegaly in children: laparoscopic versus open splenectomy. (medscape.com)
  • Laparoscopic versus open splenectomy and devascularization for massive splenomegaly due to portal hypertension. (medscape.com)
  • Casaccia M, Sormani MP, Palombo D, Dellepiane C, Ibatici A. Laparoscopic Splenectomy Versus Open Splenectomy In Massive and Giant Spleens: Should we Update the 2008 EAES Guidelines? (medscape.com)
  • Shin RD, Lis R, Levergood NR, Brooks DC, Shoji BT, Tavakkoli A. Laparoscopic versus open splenectomy for splenomegaly: the verdict is unclear. (medscape.com)
  • Li Y, Zhang D, Hua F, Gao S, Wu Y, Xu J. Factors associated with the effect of open splenectomy for immune thrombocytopenic purpura. (medscape.com)
  • Although there has not yet been a single prospective randomized study to support any advantage of laparoscopic over open splenectomy (OS), the laparoscopic approach has rapidly become very popular and has even been proposed as "gold standard" for splenectomy in hematologic diseases with normal size or moderately enlarged spleens. (nih.gov)
  • Indications for LS are the same than for open splenectomy. (nih.gov)
  • The animals were distributed into three groups: Group IA of open splenectomy (laparotomy) using double ligation of the vessels of the splenic hilum with poliglicolic acid, Group IB of open splenectomy (laparotomy) with bipolar electrocoagulation of the splenic hilum, and Group II of laparoscopic access with bipolar electrocoagulation of the splenic hilum. (scielo.br)
  • No differences were found in the evaluation of parameters between both open splenectomy techniques employed. (scielo.br)
  • Open splenectomy - Obesity, scar tissue or other conditions can make traditional surgery necessary. (templehealth.org)
  • A comparison of laparoscopic versus open splenectomy in children. (ebscohost.com)
  • Compares laparoscopic versus open splenectomy among children patients in Los Angeles, California. (ebscohost.com)
  • Laparoscopic Versus Open Splenectomy in the Pediatric Population: A Contemporary Single-Center Experience. (ebscohost.com)
  • LS is believed to be superior to open splenectomy due to its minimal invasiveness, which manifests as minimal intraoperative bleeding, less pain, expedited postoperative recovery, shorter hospital stay, and lower complication rate 6 . (medsci.org)
  • Therefore, LS is preferred to open splenectomy in most adults and children. (medsci.org)
  • This approach provides laparoscopic surgeons with a direct view of the spleen anatomy, similar to that in conventional open splenectomy, as well as extending the indications of LS to patients with massive splenomegaly 9 . (medsci.org)
  • It has the same rate of success as an open splenectomy and there are fewer complications. (pdsa.org)
  • The fatality rate from the surgery is about one percent for an open splenectomy and much less for a laproscopic procedure. (pdsa.org)
  • We have developed an even less invasive technique, modified laparoscopic splenectomy and azygoportal disconnection, and compared outcomes of modified laparoscopic splenectomy and azygoportal disconnection and open splenectomy and azygoportal disconnection in patients with portal hypertension. (semanticscholar.org)
  • Laparoscopic versus open splenectomy for hypersplenism secondary to liver cirrhosis. (semanticscholar.org)
  • Total laparoscopic versus open splenectomy and esophagogastric devascularization in the management of portal hypertension: a comparative study. (semanticscholar.org)
  • Splenectomy is the surgical removal of the spleen, which is an organ that is part of the lymphatic system. (encyclopedia.com)
  • Splenectomy is the surgical removal of the spleen. (epnet.com)
  • Splenectomy is the surgical removal of the spleen due to injury or illness. (blausen.com)
  • A splenectomy is the surgical removal of the spleen, a small, hand-sized organ located in front of the left kidney and behind the stomach. (pdsa.org)
  • Removal of the spleen, a splenectomy, can reduce the need for continual transfusions to replace the red blood cells. (laparoscopic.md)
  • Surgical removal of the spleen is known as splenectomy. (vetstream.com)
  • Ligation and complete removal of the spleen is considered to hold less risk for postoperative hemorrhage than simple repair of severe splenic lacerations or trauma, or partial splenectomy. (vetstream.com)
  • Splenectomy, also written as spleenectomy, is the surgical removal of the spleen, an organ which is the part of the lymphatic system. (medicaltourismco.com)
  • Laparoscopic splenectomy - This procedure involves the removal of the spleen via various small incisions, and this procedure is fast becoming the preferred method to operate. (medicaltourismco.com)
  • How might removal of the spleen (splenectomy) result in an increase in the number of circulating platelets? (healthtap.com)
  • A splenectomy is the surgical removal of the spleen which is sometimes required after a traumatic chest injury, like those that could be sustained in a car crash. (healthguideinfo.com)
  • We report a case of recurrent thromboembolic disease and chronic pulmonary hypertension in an adult patient with pyruvate kinase deficiency who underwent splenectomy as a child. (nih.gov)
  • Splenectomy is an uncommon procedure in children, and data on children who underwent splenectomy in South Africa are sparse. (scielo.org.za)
  • The records for all children aged 0 to 16 years who underwent splenectomy at Charlotte Maxeke Johannesburg Academic (CMJAH) and Chris Hani Baragwanath Academic (CHBAH) hospitals between 2000 and 2015 were reviewed. (scielo.org.za)
  • All patients between the ages of 0 and 16 years who underwent splenectomy were included in the study. (scielo.org.za)
  • Of these 38 patients, one underwent splenectomy due to intraoperative trauma, whereas the remaining 37 patients underwent splenectomy due to splenic metastasis. (dovepress.com)
  • Tumor involvement was the most common indication for splenectomy, and rare patients underwent splenectomy due to intraoperative trauma. (dovepress.com)
  • Between 2000 and 2015, 12 patients, five girls, and seven boys, with a median age of six years (3 months-13.11 years), underwent emergency or urgent splenectomy for non-traumatic conditions. (springer.com)
  • In 1952 when King and Shumaker reported fatal sepsis in five infants who underwent splenectomy for hereditary spherocytosis, they changed the concept of the spleen as an expendable organ [ 6 ]. (springer.com)
  • We herein present our experience with 12 pediatric cases that underwent splenectomy for non-traumatic conditions and discuss clinical features, imaging studies, and outcome/effect of surgical approach in these highly complex patients. (springer.com)
  • From January 2000 to October 2015, 117 children underwent splenectomy, 105 total and 12 partial. (springer.com)
  • A case report of a patient who underwent splenectomy for idiopathic thrombocytopenia purpura, with subsequent fatal VTE, highlights the importance of this issue. (jaoa.org)
  • Researchers analyzed results from 120 consecutive patients with MF who underwent splenectomy in order to determine the best candidates for the procedure. (cancernetwork.com)
  • The study results show that only 8 percent of Nplate patients (13/157) underwent splenectomy or discontinued the study prior to reporting a splenectomy compared with 35 percent of patients (27/77) in the SOC group. (amgen.com)
  • Only 1 percent of Nplate patients (2/157) underwent a splenectomy compared with 19 percent of SOC patients (15/77). (amgen.com)
  • Fifty-two (98%) patients underwent successful laparoscopic splenectomy without conversion to open procedure, with a mean operative time of 103.6 ± 38.1 minutes. (springermedizin.de)
  • Thirty-seven patients with HCV-induced cirrhosis who underwent laparoscopic splenectomy (Spx group) and 90 who did not (non-Spx group) were genotyped for IL28B and ITPA. (biomedcentral.com)
  • Vaccination for pneumococcus, H. influenza and meningococcus should be given pre-operatively if possible to minimize the chance of overwhelming post-splenectomy infection (OPSI), a rapid-developing and potentially fatal type of septicaemia. (wikipedia.org)
  • These bacteria often cause a sore throat under normal circumstances but after splenectomy, when infecting bacteria cannot be adequately opsonized, the infection becomes more severe. (wikipedia.org)
  • An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following removal (or permanent dysfunction) of the spleen. (wikipedia.org)
  • Splenectomy may be used to treat other conditions, including an enlarged spleen that is causing discomfort (splenomegaly), some blood disorders, certain cancers, infection, and noncancerous cysts or tumors. (mayoclinic.org)
  • Specifically, splenectomy increases the risks of postoperative and long-term infection, and the procedure is associated with excessive transfusion requirements. (encyclopedia.com)
  • Although it used to be said that serious infection was more likely in the first two years after splenectomy, you need to consider your susceptibility to this sort of infection as lifelong. (netdoctor.co.uk)
  • Following splenectomy you will be at increased risk of infection for the rest of your life. (netdoctor.co.uk)
  • Inform patients with immune thrombocytopenic purpura (ITP) who have undergone splenectomy that their natural defense against acute bacterial infection is decreased. (medscape.com)
  • However, there are no reliable predictors of splenectomy response, and long-term risks of infection and cardiovascular complications must be considered. (bloodjournal.org)
  • There is an increased risk of infection after splenectomy and any fever or infection should receive urgent medical treatment. (itpsupport.org.uk)
  • Children rarely have a splenectomy unless their ITP is particularly troublesome, as most recover from ITP, and the risk of infection without a spleen is far higher until the immune system becomes fully developed in teenage years. (itpsupport.org.uk)
  • No cases of overwhelming post splenectomy infection (OPSI) were noted. (scielo.org.za)
  • Infection (rare) - If your spleen is infected, doctors may advise splenectomy. (templehealth.org)
  • Risk for infection after splenectomy is familiar, but blood clots and, by extension, pulmonary hypertension are emerging as another possible threat. (acpinternist.org)
  • Overwhelming postsplenectomy infection, or OPSI, is the best known and best understood splenectomy risk. (acpinternist.org)
  • Quartan malaria developed following splenectomy 36 Years after infection in a 63-year-old hypertensive man. (ajtmh.org)
  • Two children died from pneumococcal infection five and eight years after splenectomy. (bmj.com)
  • The risks associated with total splenectomy, including overwhelming postsplenectomy infection, have led to an interest in the use of partial splenectomy as an alternative surgical option for children with congenital hemolytic anemias and hypersplenism. (ebscohost.com)
  • This procedure is particularly relevant in young children as it precludes risks of infection related to total splenectomy. (websurg.com)
  • You should have been more careful, especially since you know that your splenectomy puts you at greater risk for infection. (emdocs.net)
  • A splenectomy is the surgical procedure that partially or completely removes the spleen. (wikipedia.org)
  • Splenectomy is a surgical procedure to remove your spleen. (mayoclinic.org)
  • Splenectomy is most commonly performed using a tiny video camera and special surgical tools (laparoscopic splenectomy). (mayoclinic.org)
  • In conclusion, the laparoscopic technique is useful for splenectomy in dogs, being advantageous in terms of blood loss, surgical stress and surgical wounds. (scielo.br)
  • The investigators have devised a surgical procedure combining distal pancreatectomy with partial splenectomy, in principal allowing preservation of splenic function without compromise of oncologic principles. (clinicaltrials.gov)
  • The study intends to answer the question, is the proposed procedure, distal pancreatectomy and partial splenectomy, a viable alternative to the current standard of care, distal pancreatectomy with total splenectomy, for patients who will undergo surgical treatment of pancreas lesions arising in the body or tail of the pancreas? (clinicaltrials.gov)
  • We try to avoid splenectomy within the first 12 months after ITP diagnosis for most patients to allow for spontaneous or therapy-induced remissions, particularly in older patients who have increased surgical morbidity and lower rates of response, and in young children. (bloodjournal.org)
  • [1,4] The objective of our study was to describe the demographic profile, operative management and outcomes of children undergoing splenectomy in the largest academic paediatric surgical centres in South Africa between 2000 and 2015. (scielo.org.za)
  • A splenectomy is the surgical removal of your spleen - a blood-filtering abdominal organ. (templehealth.org)
  • The aim of the study was to analyze the underlying causes and application of splenectomy in patients with epithelial ovarian cancer (EOC) and assess its effect on the surgical satisfaction and prognosis of these patients. (dovepress.com)
  • The authors also review current guidelines for managing venous thromboprophylaxis in patients who undergo general, laparoscopic, and cancer-related surgical procedures, and they compare these patients to those who undergo splenectomy. (jaoa.org)
  • Our objective is to raise physician awareness of the unique VTE risks that splenectomy surgical procedures pose to patients. (jaoa.org)
  • Response to initial corticosteroid therapy was associated with a laparoscopic splenectomy success rate of 90% and increased odds of surgical success by 5.58 over individuals with no response to corticosteroids. (ovid.com)
  • Initial response to corticosteroids is associated with laparoscopic splenectomy success rate of 90% and improved odds of surgical success. (ovid.com)
  • Hereditary spherocytosis and partial splenectomy in children: review of surgical technique and the role of imaging. (ebscohost.com)
  • At EO Surgical Specialists, our surgeons are experienced in performing laparoscopic splenectomy, and we also coordinate the perioperative care that goes with splenectomy. (triangleortho.com)
  • Also called keyhole splenectomy, laparoscopic spleen removal is done with small surgical instruments inserted through very short incisions. (medicaltourismco.com)
  • Robot-assisted splenectomy follows the same surgical principles than a more conventional laparoscopic technique. (websurg.com)
  • Laparoscopic splenectomy is performed best for spleens enlarged to less than 20 cm, with less complications than for the equivalent open procedure. (news-medical.net)
  • Post-splenectomy complications can occur after surgery to remove the spleen. (medlineplus.gov)
  • but due to the complications associated with splenectomy (low blood cell counts, fatigue , frequent infections, and easy bleeding or bruising), physicians are now more often recommending chemotherapy. (encyclopedia.com)
  • What are the complications of splenectomy for the treatment of immune thrombocytopenic purpura (ITP)? (medscape.com)
  • Complications related to clotting, such as chronic thromboembolic pulmonary hypertension (CTEPH), also can increase following a splenectomy. (acpinternist.org)
  • Indications for splenectomy in MF include drug-refractory symptomatic splenomegaly, frequent transfusion need, refractory thrombocytopenia, and complications from portal hypertension," wrote study authors led by Ayalew Tefferi, MD, of the Mayo Clinic in Rochester, Minnesota. (cancernetwork.com)
  • Splenectomy can offer symptomatic relief and improvement in anemia and thrombocytopenia, but also carries the risk of complications including perioperative bleeding, infections, and thrombosis. (cancernetwork.com)
  • Splenectomy is the only solution to prevent complications arising from a damaged or cancerous spleen. (manipalhospitals.com)
  • The authors' clinical experience confirmed the data inferred from animal experiments: the simplicity of the preparation technique and the autologous transplantation of splenic pulp in the absence of major complications confirms the possibility of applying this method in all splenectomies performed under emergency conditions. (minervamedica.it)
  • tomy, postsplenectomy complications, mor-bidity, mortality) Splenectomy is a widely accepted procedure in the management of many hematologic dis-ease processes. (oclc.org)
  • During the past two decades, many studies'-8 have suggested that there is a high-er rate of early postoperative complications (pri-marily infectious) among patients undergoing splenectomy as compared with the rate among similar patients undergoing similar operations. (oclc.org)
  • Splenectomy is an effective therapy for steroid-refractory or dependent immune thrombocytopenia (ITP). (bloodjournal.org)
  • Describe the efficacy of splenectomy and predictors of treatment response in patients with immune thrombocytopenia (ITP), based on a review. (bloodjournal.org)
  • Traumatic injury was previously the leading indication for splenectomy, but with improved splenic preservation techniques, this is now second most common (35-40%), behind hematologic conditions (40-50%), with idiopathic thrombocytopenia purpura being most common. (clinicaladvisor.com)
  • Indications for splenectomy included diffuse resistant splenic abscesses (4), intracranial hemorrhage (4) or hypersplenism (3) with refractory thrombocytopenia, and spontaneous splenic rapture (1). (springer.com)
  • In an analysis of 148 adults with immune thrombocytopenia (2), a subgroup of 8 patients with systemic lupus erythematosus responded to prednisone and subsequent splenectomy in a way that was indistinguishable from that of patients with the idiopathic variant. (annals.org)
  • When dealing with patients with thalassemia, splenectomy is a common therapeutic option, particularly indicated when the patient has increased transfusion demand, symptomatic splenomegaly or any signs of poor health, leucopenia, and thrombocytopenia. (scielo.br)
  • In 2007, he was diagnosed as having idiopathic thrombocytopenia purpura (ITP), leading to his first splenectomy. (jaoa.org)
  • In a climate of new available medical therapies for immune thrombocytopenia, the comparative safety and efficacy of laparoscopic splenectomy are worthy of attention. (ovid.com)
  • A retrospective cohort study was conducted of patients undergoing laparoscopic splenectomy for immune thrombocytopenia. (ovid.com)
  • Laparoscopic splenectomy is a safe and effective intervention for immune thrombocytopenia regardless of age. (ovid.com)
  • Laparoscopic splenectomy should be the standard second-line therapy for immune thrombocytopenia, especially in patients responding to corticosteroids. (ovid.com)
  • BACKGROUND: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70-80% response rate. (luriechildrens.org)
  • Splenectomy is a well-established second-line treatment for immune thrombocytopenia but novel medical therapies have changed the management of this disease. (springermedizin.de)
  • Retrospective analysis of 53 consecutive patients with chronic immune thrombocytopenia submitted to splenectomy from January 2007 through December 2014. (springermedizin.de)
  • In our experience, laparoscopic splenectomy is an effective second-line treatment for Immune Thrombocytopenia with short and long-term response rates of 94% and 91%, respectively. (springermedizin.de)
  • Splenectomy improved SVR rate among patients carrying IL28B minor genotype and protected against anemia and thrombocytopenia during the course of PEG-IFN/RBV therapy regardless of ITPA genotype. (biomedcentral.com)
  • RESULTS: Thrombocytopenia was cured in 14 of 15 patients who had splenectomy, but it recurred intermittently in three. (ox.ac.uk)
  • Splenectomy is generally a safe procedure. (mayoclinic.org)
  • Splenectomy is the procedure performed to remove the spleen. (news-medical.net)
  • A child will get general anesthesia before a splenectomy to sleep through the procedure and not feel pain. (kidshealth.org)
  • The purpose of the current study was to describe a laparoscopic splenectomy technique and the alterations due to this access, and compare it to the open procedure in dogs. (scielo.br)
  • Splenectomy is often carried out as a laparoscopic procedure (keyhole surgery) which has the advantage of a shorter hospital stay and quicker recovery time. (itpsupport.org.uk)
  • Splenectomy is a well-described procedure in children. (scielo.org.za)
  • Partial splenectomy, a procedure designed. (ebscohost.com)
  • Robot-assisted splenectomy is a safe and reproducible procedure. (websurg.com)
  • A splenectomy is usually performed if the spleen has become irreparably damaged (often as a result of a traumatic injury) and often is carried out as an emergency procedure. (healthguideinfo.com)
  • 257 The first group included those whose indication was medical and whose splenectomy was a planned and elective procedure. (oclc.org)
  • Our patient presented at age 37 with recurrent pulmonary emboli, 36 years after splenectomy for severe hemolytic anemia. (nih.gov)
  • The presence of 3 or more of these 4 risk factors was associated with an extremely poor outcome with median survival of less than 6 months, and no patients surviving for 3 years after splenectomy," the authors wrote. (cancernetwork.com)
  • Surgeons are sometimes forced to remove the spleen (splenectomy) to control the bleeding that results from its injury. (netdoctor.co.uk)
  • In a laparoscopic splenectomy, a tiny camera and four small incisions are used to remove the spleen. (triangleortho.com)
  • When it is necessary to remove the spleen, it is important that certain vaccinations are given just before or after the splenectomy. (triangleortho.com)
  • We also performed hand‐assisted laparoscopic splenectomy to ensure easy handling of the splenomegaly. (ingentaconnect.com)
  • Frequently, failure of medical therapy to control the splenic sequelae of haematological disorders, e.g. splenomegaly, hypersplenism and massive infarction, necessitates splenectomy. (scielo.org.za)
  • Presents a laparoscopic splenectomy (LS) technique in treating hypersplenism and splenomegaly in children with sickle cell disease in Charleston, South Carolina. (ebscohost.com)
  • She reported a family history of thalassemia and a personal history of splenectomy in 2001 due to a painful splenomegaly. (scielo.br)
  • Laparoscopic splenectomy for massive splenomegaly: technical aspects of initial ligation of splenic artery and extraction without hand-assisted technique. (semanticscholar.org)
  • CONCLUSION: LS should be considered as a safe and effective therapy when elective splenectomy is indicated for chronic ITP patients. (biomedsearch.com)
  • A 44-year-old white man presented to our institution in 2010 for an elective splenectomy after recurrence of splenosis, a condition characterized by regeneration of splenic tissues following previous splenectomies. (jaoa.org)
  • It was assumed that the mag-nitude of invasiveness for elective splenectomy and for elective open cholecystectomy was similar. (oclc.org)
  • Vaccinations against hepatitis B, pneumococcal infections, meningitis and hæmophilus influenzæ,will be given before the splenectomy is carried out, or immediately afterwards in the case of an emergency splenectomy. (itpsupport.org.uk)
  • Although the pre-, peri- and postoperative management of paediatric patients undergoing elective and emergency splenectomy is well described within the international literature, there is a paucity of such literature in the South African (SA) context. (scielo.org.za)
  • Emergency splenectomy is rarely performed since a widespread consensus exists towards conservative management of splenic injury. (springer.com)
  • Rarely, an emergency splenectomy is required in complex settings, mostly refractory hematological conditions, in a deteriorating patient when all other measurements have failed. (springer.com)
  • Emergency splenectomy in children for reasons other than trauma is a treatment of last resort that should be performed in a multidisciplinary context. (springer.com)
  • The outcome of emergency splenectomy in children for reasons other than trauma depends on the underlying medical condition. (springer.com)
  • I had a emergency splenectomy 5 years ago. (healthtap.com)
  • Most infections occur in the first few years following splenectomy, but the risk of OPSI is lifelong. (wikipedia.org)
  • Partial splenectomy is performed only in certain specific conditions such as Gaucher's disease, to preserve some splenic function while preventing hypersplenism. (news-medical.net)
  • Most splenectomies are done after the patient has been diagnosed with hypersplenism. (encyclopedia.com)
  • Because serious consequences may result from removal of immune system organs such as the spleen, the decision to perform a splenectomy depends on the severity and prognosis of the disease or condition causing the hypersplenism. (encyclopedia.com)
  • The indication for splenectomy can be divided into six categories: hypersplenism, trauma/injury, autoimmune/erythrocyte disorder, primary tumor/mass, incidental, and diagnostic. (clinicaladvisor.com)
  • Furthermore, for patients with hypersplenism, it is important to attempt medical optimization before even deciding to proceed with a splenectomy. (clinicaladvisor.com)
  • Hypersplenism caused by extramedullary hematopoiesis necessitates splenectomy [ 7 ]. (termedia.pl)
  • Most splenectomy surgeries are performed when a patient has been diagnosed with hypersplenism, which is not one specific diseases but a cluster of symptoms or a syndrome. (medicaltourismco.com)
  • Risk Factors for Portal Vein System Thrombosis After Laparoscopic Splenectomy in Cirrhotic Patients with Hypersplenism. (semanticscholar.org)
  • Laparoscopic splenectomy and azygoportal disconnection for bleeding varices with hypersplenism. (semanticscholar.org)
  • Most resectable tumors arising in the body or tail of the pancreas are malignancies or premalignancies which are surgically treated with distal pancreatectomy in combination with splenectomy. (clinicaltrials.gov)
  • To date, distal pancreatectomy with partial splenectomy has not been described in the medical literature. (clinicaltrials.gov)
  • 2. Splenectomy with distal pancreatectomy. (aapc.com)
  • Although favorable postoperative short-term outcomes have been reported in open spleen-preserving distal pancreatectomy when compared to distal pancreatectomy with splenectomy, it is unclear whether this observation applies to the laparoscopic approach. (springer.com)
  • The aim of this study is to compare laparoscopic spleen-preserving distal pancreatectomy (LSPDP) with laparoscopic distal pancreatectomy with splenectomy (LDPS). (springer.com)
  • Historically, distal pancreatectomy has been carried out with concomitant splenectomy as a result of the spleen having anatomical proximity to, and sharing principal vessels with, the left pancreas [ 5 ]. (springer.com)
  • The aim of this study was to review the authors' experience with SIPES splenectomy and compare it with conventional laparoscopic splenectomy. (ebscohost.com)
  • Blood disorders that may be treated with splenectomy include idiopathic thrombocytopenic purpura, polycythemia vera and thalassemia. (mayoclinic.org)
  • An increased prevalence of splenectomy has been reported in patients with idiopathic pulmonary arterial hypertension. (bmj.com)
  • In a case-control study the prevalence of splenectomy in patients with CTEPH was compared with that of patients evaluated during the same period for idiopathic pulmonary hypertension (n = 276) or for lung transplantation in other chronic pulmonary conditions (n = 180). (bmj.com)
  • An increased prevalence of splenectomy has been reported in patients with so-called idiopathic pulmonary arterial hypertension, suggesting a link between splenectomy and the occurrence of this rare pulmonary vascular condition. (bmj.com)
  • [1-4 Common examples of haematological disorders that necessitate splenectomy in children are hereditary spherocytosis (HS), sickle cell disease (SCD) and idiopathic thrombocytopaenic purpura (ITP). (scielo.org.za)
  • To the editor: In 1985, Hall and colleagues (1) reported on 14 patients in whom platelet counts after splenectomy followed a different pattern from those in patients with idiopathic thrombocytopenic purpura treated in the same way. (annals.org)
  • This video demonstrates a splenectomy for idiopathic thrombocytopenic purpura (ITP) in a young patient. (websurg.com)
  • Diseases such as leukemia or hemolytic anemia can also require splenectomy. (blausen.com)
  • Erythrocyte and autoimmune disorders such as hereditary spherocytosis (congenital hemolytic anemia) often require a splenectomy, including careful removal of the accessory spleen. (clinicaladvisor.com)
  • In hereditary spherocytosis and in some cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production. (annals.org)
  • Massive splenic infarction in children with sickle cell anemia and the role of splenectomy. (ebscohost.com)
  • The purpose of this study is to evaluate the role of splenectomy in potentially curative total gastrectomy for proximal gastric carcinoma in terms of survival benefit and post-operative morbidity. (clinicaltrials.gov)
  • In these conditions the immediate effect of splenectomy on red cell production is usually obscured by preoperative transfusions or by autotransfusions from the surgically manipulated spleen. (annals.org)
  • Modulation of this response by splenectomy constitutes an option to protect the heart from MI/R. To mimic the effect of splenectomy in a pharmacological approach, the sphingosine-1-phosphate agonist FTY720 was applied at the onset of reperfusion. (ovid.com)
  • Kurtoğllu A, Koçtekin B, Kurtoğlu E, Yildiz M. The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major. (termedia.pl)
  • Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice," Clinical and Developmental Immunology , vol. 2010, Article ID 614890, 8 pages, 2010. (hindawi.com)
  • Furthermore, we investigated the effects of splenectomy on the infiltration of CD4 + T, CD8 + T, B cells and macrophages into pancreatic tissues and the relationship between mononuclear cells and pancreatitis developing in splenectomized aly/aly mice, which have a complete absence of secondary lymphoid organs. (hindawi.com)
  • Depending on the exact indication for splenectomy and underlying co-morbidities, a splenectomy can be either urgent or semi-elective. (clinicaladvisor.com)
  • Depending on the exact indication for splenectomy and length of time with the given affliction, the concerns can be quite varied. (clinicaladvisor.com)
  • Subsets of patients according to indication for splenectomy were compared with a cohort of patients having elective open cholecystectomy. (oclc.org)
  • Researchers in the United Kingdom, France and Spain feel that an indium white blood cell screening test has some value in predicting whether a splenectomy will successfully raise your platelet counts. (pdsa.org)
  • This is the first study to compare a variety of ITP treatments and demonstrated that Nplate not only maintained platelet counts more effectively than standard medical treatments, but also reduced overall treatment failure and splenectomies," said Dr. David J. Kuter , head of Hematology, Massachusetts General Hospital, Boston , and lead investigator and study author. (fiercebiotech.com)
  • Secondary endpoints of the study included time to splenectomy, platelet counts, and platelet response. (fiercebiotech.com)
  • In the follow-up (mean 24.8 ± 16.9 months) 37 (75.5%) patients had a complete and sustained response after laparoscopic splenectomy and an additional 11 (22.4%) presented platelet counts above 30×10 9 /L (the majority of these patients eventually reaching normal platelet counts). (springermedizin.de)
  • In this video abstract, we present an interesting case of posterior, lateral diaphragmatic hernia occurring ten years after a difficult splenectomy for lymphoma. (sages.org)
  • Unstable trauma patients who have suspicion of splenic injury and evidence of blood, either by deep perintoneal lavage or by a focus abdominal songraphic technique study, should proceed straight to the operating room for exploration, and preferably undergo a splenic repair versus splenectomy. (clinicaladvisor.com)
  • The most common causes of splenectomy are trauma and hematologic disorder. (acpinternist.org)
  • As trauma remains the most common cause of splenic rupture requiring splenectomy, pediatric surgeons were the first to apply the concept of non-operative treatment for children with blunt spleen injury and becoming gold standard during the 1980s [ 11 ]. (springer.com)
  • The diagnosis and management of splenic trauma has evolved has been a longtime norm and overwhelming post-splenectomy firm clinical guidelines. (cardinaloconnorconference.com)
  • Cats undergoing splenectomy for trauma, abscess or benign mass that survive the perioperative course have favorable outcomes. (vetstream.com)
  • Trauma, both blunt and penetrating, was the most common reason for splenectomy. (bmj.com)
  • 3, 4 However, there are many clinical indications that warrant a total splenectomy, such as extensive splenic trauma or haematological disorders, resulting in a large population of asplenic patients. (bmj.com)
  • A 57-year-old male 38 years post-splenectomy for trauma stops by his mini-storage unit. (emdocs.net)
  • Since the first laparoscopic splenectomy (LS) performed by Delaître in 1991, numerous case series have shown the feasibility of LS for a large variety of benign and malignant hematologic diseases. (nih.gov)
  • Splenectomies may be performed for diagnosis, staging or treatment of a variety of benign or malignant hematologic diseases. (nih.gov)
  • Some childhood hematologic disorders such as hereditary spherocytosis are successfully treated with partial splenectomy. (clinicaltrials.gov)
  • Venous thromboembolism (VTE) occurs in approximately 10% of patients after splenectomy, particularly splenectomy performed for hematologic abnormalities. (jaoa.org)
  • Doctors vaccinate those about to have a splenectomy with polyvalent pneumococcal, meningococcal C conjugate, and H influenza b (Hib) vaccines. (pdsa.org)
  • Question 12 from the second paper of 2008 asked about pneumococcal meningitis in the post-splenectomy in the post-splenectomy patient. (cardinaloconnorconference.com)
  • Continued need for pneumococcal prophylaxis after splenectomy. (bmj.com)
  • Results of laparoscopic splenectomy for immune thrombocytopenic purpura. (biomedsearch.com)
  • Most patients currently scheduled for splenectomy undergo LS via the anterior approach 8 . (medsci.org)
  • The authors discuss the pathophysiologic mechanisms of VTE in patients who undergo splenectomy and offer management strategies for this complication. (jaoa.org)
  • Survival of patients with myelofibrosis (MF) who undergo splenectomy is adversely affected by older age, the need for transfusion, and leukocyte and circulating blast cell counts, according to a new analysis. (cancernetwork.com)
  • Laparoscopic splenectomy - Once you are placed under general anesthesia, your doctor places an inflatable cannula (tube) into your abdomen to make room to operate. (templehealth.org)
  • A splenectomy is performed while the patient is under general anesthesia. (medicaltourismco.com)
  • There are two diseases for which splenectomy is the only treatment - primary cancers of the spleen and a blood disorder called hereditary spherocytosis (HS). (encyclopedia.com)
  • The urgency should be balanced against appropriate vaccinations, exhaustion of other treatment modalities, and a full evaluation of other morbidities contributing to the need for a splenectomy, such as evidence of iron overload in patients with hereditary spherocytosis or optimization of a chemotherapy regimen in a cancer patient. (clinicaladvisor.com)
  • For this reason, patients who are about to have a splenectomy should receive elective immunization with pneumococcus vaccine from one week before the surgery at latest, to three weeks before, which is ideal. (news-medical.net)
  • A splenectomy (splih-NEK-tuh-mee) is surgery to remove an injured spleen. (kidshealth.org)
  • Unfortunately these indications for surgery are rare and so the experience with partial splenectomy is small. (clinicaltrials.gov)
  • A splenectomy (say "splih-NEK-tuh-mee") is surgery to take out the spleen. (conehealth.com)
  • A laparoscopic splenectomy is a form of surgery used to get rid of the spleen. (laparoscopyhospital.com)
  • In laparoscopic splenectomy shorter hospital stay is required, there is less pain after surgery, have less scarring and faster healing than traditional surgery. (laparoscopyhospital.com)
  • We also report a literature review concerning the efficacy and safety of splenectomy during cytoreductive surgery in EOC. (dovepress.com)
  • Splenectomy should be attempted in all patients with splenic involvement in whom optimal cytoreductive surgery was achievable, no matter in primary or secondary cytoreduction. (dovepress.com)
  • The incidence of thrombosis involving the portal venous system after splenectomy ranges from 5% to 37%, all occurring within two months of surgery. (acpinternist.org)
  • The splenectomy was considered emergency because if not performed, there would have been colossal risk to patient's life and urgent when further deterioration of the child's health would have been expected without surgery. (springer.com)
  • Laparoscopic splenectomy (LS) has been increasingly used in general surgery since the first reported adult LS in 1991 1 . (medsci.org)
  • In the present article, we offer a case report and clinical vignette that highlight morbidity associated with VTE after surgery-specifically after splenectomy procedures. (jaoa.org)
  • Subtotal splenectomy should reduce the size of the splenic parenchyma by 80% in order to prevent recurrence and completion surgery in the short term. (websurg.com)
  • Splenectomy abroad, is a much welcome option for patients requiring a splenectomy surgery at the earliest but cannot get one in their home country due to high costs, long waiting lists or lack of advanced medical facilities. (medicaltourismco.com)
  • Splenectomy is a complicated surgery and it is very important that the patient gets it done at a hospital which has a well versed set of surgeons and state-of-the-art medical facilities. (medicaltourismco.com)
  • A splenectomy surgery is performed for various reasons, and there are different procedures which can be followed for the operation. (medicaltourismco.com)
  • On this page, you will find information on spleen removal surgery, different procedures, a brief overview on the recovery, and a note on getting a splenectomy surgery abroad with special emphasis on India. (medicaltourismco.com)
  • Why is a Splenectomy Surgery Performed? (medicaltourismco.com)
  • In addition to the above mentioned reasons, there are various other major or minor factors due to which the doctor might advise a splenectomy surgery. (medicaltourismco.com)
  • Complete Splenectomy - A complete splenectomy surgery is performed is two cases, either when an enlarged spleen is to be removed or when a ruptured spleen has to be removed. (medicaltourismco.com)
  • The authors report their experience regarding the use of autologous splenic transplantation in post-traumatic splenectomy unable to be treated using conservative surgery. (minervamedica.it)
  • If performed by experts in this field, laparoscopic splenectomy is as safe as 'open' surgery in carefully selected cases. (rwjbh.org)
  • The most common reason for splenectomy is to treat a ruptured spleen, which is often caused by an abdominal injury. (mayoclinic.org)
  • Rates of splenectomy are declining, but thromboembolic disease following splenectomy is now more recognized and therefore being diagnosed more frequently in the primary care setting. (acpinternist.org)
  • Splenectomy is actually being performed less frequently, but thromboembolic disease following splenectomy is perhaps now more recognized and therefore being diagnosed more frequently," said Shelley Crary, MD, a pediatrician and associate professor of pediatric hematology-oncology at the University of Arkansas for Medical Sciences. (acpinternist.org)
  • We therefore report a case of a woman with hemoglobin (Hb) C/β 0 -thalassemia and recurrent venous thromboembolism after splenectomy. (scielo.br)
  • Ha LP, Arrendondo M. Fatal Venous Thromboembolism After Splenectomy: Pathogenesis and Management. (jaoa.org)
  • INTERPRETATION AND CONCLUSIONS: Splenectomy, by eliminating a source of pathogenic autoantibody production, can be a successful treatment for patients with relapsing or plasma-refractory acquired TTP due to autoantibody-mediated ADAMTS-13 deficiency. (haematologica.org)
  • CONCLUSIONS: Overall, splenectomy rates consistently declined over time. (luriechildrens.org)
  • There also is some conjecture that post-splenectomy patients may be at elevated risk of subsequently developing diabetes. (wikipedia.org)
  • Regardless of how long ago one's spleen was removed, post-splenectomy patients are high risk. (emdocs.net)
  • Mild thrombocytosis may be observed after a splenectomy due to the lack of sequestering and destruction of platelets that would normally be carried out by the spleen. (wikipedia.org)
  • In addition, the splenectomy may result in a slight increase in the production of platelets within the bone marrow. (wikipedia.org)
  • The spleen removes platelets from the blood, so a splenectomy can help the body keep more of these important cells. (kidshealth.org)
  • In the UK leading ITP specialists only carry out splenectomy when all other options have been exhausted, and it has been preceded by an indium labelled platelet spleen scan (performed in the nuclear medicine department of certain hospitals) to investigate whether the platelets are being destroyed in the spleen. (itpsupport.org.uk)
  • If this test shows that platelets are mainly being destroyed elsewhere in the immune system a splenectomy is unlikely to raise the platelet count. (itpsupport.org.uk)
  • Therefore, splenectomies are not always successful in raising the platelet count and may fail over time, prompting a return of low platelets. (pdsa.org)
  • While a splenectomy may raise the platelet count, it does not eliminate ITP since the antibody-coated platelets remain in circulation. (pdsa.org)
  • Noncancerous cysts or tumors inside the spleen may require splenectomy if they become large or are difficult to remove completely. (mayoclinic.org)
  • The results of this case suggest that we should consider sclerosing angiomatoid nodular transformation in the differential diagnosis of patients with splenic tumors, as sclerosing angiomatoid nodular transformation with hemangiomatous features may cause coagulation disorders for which splenectomy should be performed. (ingentaconnect.com)
  • Occasionally, tumors of surrounding structures (stomach, spleen, and kidney) extend or involve the spleen, necessitating an en-bloc resection. (clinicaladvisor.com)
  • Ji B, Wang Y, Zhang P, Wang G, Liu Y. Anterior Versus Posterolateral Approach for Total Laparoscopic Splenectomy: A Comparative Study. (medsci.org)
  • Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome. (ox.ac.uk)
  • AIM: To assess the results of supportive treatment with intravenous immunoglobulin (IVIG) and antibiotic prophylaxis in combination with splenectomy in patients with Wiskott-Aldrich syndrome. (ox.ac.uk)
  • CONCLUSION: Adequate supportive treatment with IVIG and antibiotic prophylaxis together with splenectomy enables good survival and quality of life in the short and medium term in patients with Wiskott-Aldrich syndrome. (ox.ac.uk)
  • OBJECTIVE: To study the safety and efficacy of Laparoscopic Splenectomy (LS) for Immune Thrombocytopenic Purpura (ITP). (biomedsearch.com)
  • At the time of splenectomy, patients had a median age of 66 years, and 58% were male. (cancernetwork.com)
  • 5 Thus, patient education and counselling at the time of splenectomy is just as important as appropriate vaccination and antibiotic prophylactic measures. (bmj.com)
  • If thrombocytosis occurs as a result of splenectomy, it requires life-long antiplatelet treatment. (clinicaltrials.gov)
  • The result of splenectomy in 34 new patients is presented with a critical review of results obtained in a total of 299 cases collected from the literature. (aacrjournals.org)
  • It was decided to rapidly perform a splenectomy. (websurg.com)
  • Congenital dyserythropoietic anaemia: response to splenectomy and quantitation of ineffective erythropoiesis. (bmj.com)
  • There was a pronounced haemolytic component to the anaemia, with a mean cell life of five days, and a remarkable response to splenectomy. (bmj.com)
  • Previous response to corticosteroids (such as Prednisone), IVIG or other treatments are not very good predictors of splenectomy success. (pdsa.org)
  • The reasons behind CTEPH have remained elusive, but new research is starting to shed more light on the issue and on the important role of primary care in monitoring and treating patients after splenectomy. (acpinternist.org)
  • Splenic neoplasms (lymphoma, metastatic cancers) are rare but important indications for splenectomy. (clinicaladvisor.com)
  • There are two categories of indications for splenectomy. (evergreenhealth.com)
  • Indications for splenectomy included suspected pancreatic ductal adenocarcinoma (PDAC), suspected lymphoma, presence of concomitant splenic vein thrombosis, suspected MCN larger than 4 cm, lesions in close proximity to the splenic hilum and NET with a high Ki67 index. (springer.com)
  • Laparoscopic splenectomy and azygoportal disconnection has been reported safe, feasible and minimally invasive for patients with portal hypertension. (semanticscholar.org)
  • Laparoscopic splenectomy and esophagogastric devascularization is a safe, effective, minimally invasive alternative for the treatment of portal hypertension with refractory variceal bleeding. (semanticscholar.org)
  • Laparoscopic splenectomy and periesophagogastric devascularization with endoligature for portal hypertension in children. (semanticscholar.org)
  • In case of hemolytic disease, subtotal splenectomy is an alternative to total splenectomy, the efficacy of which has been evidenced in the literature (Inter J Surg 2010;8:48-51). (websurg.com)
  • Anecdotal reports of splenectomy date back to the 16th century and by 1920 operative mortality rates of about 10% had been reported by Mayo Clinic on splenectomy. (laparoscopyhospital.com)
  • To describe the profile, operative management and outcomes of children undergoing splenectomy. (scielo.org.za)
  • European clinical trials of gastrectomy showed that splenectomy is an important risk factor for post-operative morbidity and mortality. (clinicaltrials.gov)
  • However, Japanese studies revealed that 20 - 30 % of patients with non-early carcinoma in the proximal stomach have nodal metastasis in the splenic hilum and therefore, pancreas-preserving splenectomy is part of the standard operation in specialized centers where splenectomy is not considered a risk factor for operative mortality. (clinicaltrials.gov)
  • Historically, surgeons have had little hesitation in performing splenectomy as a "logical" extension of other operative procedures or for traumatic injury, including minor iatro-genic capsular tears. (oclc.org)
  • Cancers that may be treated with splenectomy include chronic lymphocytic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma and hairy cell leukemia. (mayoclinic.org)
  • Four patients died in 2205 months of observation before and after splenectomy (median 82, range 16-248): two of cerebral B cell lymphoma, one of progressive multifocal leucoencephalopathy, and one with severe chronic chest disease of pneumonia. (ox.ac.uk)
  • Because of the possibility of a primarysplenic lymphoma, an opened splenectomy wasper formed. (abdominalsurg.org)
  • Partial splenectomy refers to removal of part of the spleen, and is usually done to relieve splenic enlargement in Gaucher's disease, or for the sake of a biopsy. (news-medical.net)
  • Partial splenectomy has also been successful ly employed to treat benign and malignant lesions of the spleen. (clinicaltrials.gov)
  • In rare cases, preservation of splenic function may be attempted with partial splenectomy for known non-neoplastic processes such as abscesses or hematomas, however, it should not be considered if neoplasia has not been ruled out. (vetstream.com)
  • Depending upon the patient's condition, splenectomy can either be partial or complete. (medicaltourismco.com)
  • Partial Splenectomy - When the spleen is not entirely damaged and a partial removal of the organ will suffice, a partial splenectomy is performed. (medicaltourismco.com)
  • According to a 2014 study published in the Journal of the Society of Laparoendoscopic Surgeons , 7,050 splenectomies were done in 2007, 6,304 took place in 2008, 6,174 took place in 2009, and 5,998 took place in 2010. (acpinternist.org)
  • Splenectomies are performed for a variety of different reasons and with different degrees of urgency. (encyclopedia.com)
  • Depending upon the problem and the patient's individual circumstances, the doctor will advise a splenectomy with varied degrees of urgency. (medicaltourismco.com)
  • It has become more common for splenectomy to be performed laparoscopically, and this confers a higher risk for these early postoperative thrombotic events, according to Dr. Tavakkoli. (acpinternist.org)
  • Cognizant of these studies that implicate splenec-tomy as a cause of early postoperative morbidi-ty and mortality, we undertook a retrospective analysis to further understand and define the negative impact of splenectomy performed in our institution. (oclc.org)
  • Retrieved on August 24, 2019 from https://www.news-medical.net/health/Splenectomy-(Spleen-Removal).aspx. (news-medical.net)