AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
SplenectomyHypersplenismSplenic DiseasesSplenomegalySplenic NeoplasmsPurpura, Thrombocytopenic, IdiopathicSplenic VeinSplenic ArterySplenic RuptureSpherocytosis, HereditarySpleenPlatelet CountPurpura, ThrombocytopenicLaparoscopyHypertension, PortalLaparoscopesSplenosisHematologic DiseasesEcchymosisPancreatectomySplenic InfarctionPostoperative ComplicationsThrombocytopeniaAnemia, Hemolytic, AutoimmuneTuberculosis, SplenicGaucher DiseaseSplenorenal Shunt, SurgicalPrimary MyelofibrosisAnemia, Hemolytic, CongenitalEsophageal and Gastric VaricesWandering SpleenFelty SyndromeWounds, NonpenetratingPortal VeinLeukemia, Hairy Cell
Splenectomy
Surgical procedure involving either partial or entire removal of the spleen.
Hypersplenism
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Splenic Diseases
Splenomegaly
Enlargement of the spleen.
Splenic Neoplasms
Tumors or cancer of the SPLEEN.
Purpura, Thrombocytopenic, Idiopathic
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Splenic Vein
Vein formed by the union (at the hilus of the spleen) of several small veins from the stomach, pancreas, spleen and mesentery.
Splenic Artery
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Splenic Rupture
Spherocytosis, Hereditary
A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.
Spleen
An encapsulated lymphatic organ through which venous blood filters.
Platelet Count
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Purpura, Thrombocytopenic
Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.
Laparoscopy
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Hypertension, Portal
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Laparoscopes
ENDOSCOPES for examining the abdominal and pelvic organs in the peritoneal cavity.
Splenosis
The spontaneous transplantation of splenic tissue to unusual sites after open splenic trauma, e.g., after automobile accidents, gunshot or stab wounds. The splenic pulp implants appear as red-blue nodules on the peritoneum, omentum, and mesentery, morphologically similar to multifocal pelvic endometriosis. (Segen, Dictionary of Modern Medicine, 1992)
Hematologic Diseases
Disorders of the blood and blood forming tissues.
Ecchymosis
Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.
Pancreatectomy
Surgical removal of the pancreas. (Dorland, 28th ed)
Splenic Infarction
Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Thrombocytopenia
A subnormal level of BLOOD PLATELETS.
Anemia, Hemolytic, Autoimmune
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Tuberculosis, Splenic
Infection of the spleen with species of MYCOBACTERIUM.
Gaucher Disease
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
Splenorenal Shunt, Surgical
Anastomosis of splenic vein to renal vein to relieve portal hypertension.
Primary Myelofibrosis
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Anemia, Hemolytic, Congenital
Hemolytic anemia due to various intrinsic defects of the erythrocyte.
Esophageal and Gastric Varices
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
Wandering Spleen
A congenital or acquired condition in which the SPLEEN is not in its normal anatomical position but moves about in the ABDOMEN. This is due to laxity or absence of suspensory ligaments which normally provide peritoneal attachments to keep the SPLEEN in a fixed position. Clinical symptoms include ABDOMINAL PAIN, splenic torsion and ISCHEMIA.
Felty Syndrome
A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.
Wounds, Nonpenetrating
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Portal Vein
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Leukemia, Hairy Cell
A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.

Intensive investigation in management of Hodgkin's disease. (1/1406)

Ninety-eight patients with clinically localised Hodgkin's disease underwent laparotomy and splenectomy to determine the extent of microscopic spread. In 68 patients the procedure was carried out for untreated disease apparently confined above the diaphragm. Abdominal disease cannot be confidently excluded on the basis of non-invasive investigation at presentation. Clinical assessment of splenic disease was unreliable unless gross splenomegaly was present. Pedal lymphography was accurate in assessing para-aortic and iliac disease but of no value in assessing other intra-abdominal lymph node involvement, including that of the mesenteric lymph node. Trephine bone marrow biopsy findings were normal in all patients before surgery, and only one patient was found to have diseased bone marrow by Stryker-saw biopsy at operation. Liver disease was identified at operation in nine patients, some of whom were asymptomatic with clinically undetectable splenic and nodal disease. Detailed clinical staging failed to detect disease in one-third of patients who underwent laparotomy. These studies show that if radiotherapy is to remain the treatment of choice for disease truly localised to lymph nodes a detailed staging procedure, including laparotomy and splenectomy, remains essential. The value of this potentially curative treatment is considerably diminished in the patient who has been inadequately staged.  (+info)

Immune response capacity after human splenic autotransplantation: restoration of response to individual pneumococcal vaccine subtypes. (2/1406)

OBJECTIVE: To evaluate features of general immune function, in particular the restoration of the humoral immune response to pneumococcal capsular polysaccharides, in humans undergoing a spleen autotransplantation after splenectomy because of trauma. SUMMARY BACKGROUND DATA: After splenectomy, patients have an increased risk of overwhelming infection or sepsis involving encapsulated bacteria such as pneumococci. The value of human spleen autotransplantation after splenectomy because of trauma has long been questioned. Mononuclear phagocyte system function appeared to be similar to that in splenectomized persons. The presence of specific antipneumococcal antibodies would allow other parts of the mononuclear phagocyte system, such as those in the liver, to phagocytose opsonized bacteria. METHODS: Ten consecutive patients undergoing splenectomy followed by autotransplantation were compared with the next 14 consecutive patients undergoing splenectomy alone. After a minimum of 6 months, the patients were vaccinated with 23-valent pneumococcal vaccine. Blood samples were taken at the time of vaccination and after 3 and 6 weeks for antipneumococcal capsular polysaccharides IgM and IgG enzyme-linked immunosorbent assay against types 3, 4, 6, 9, 14, and 23. Splenic regrowth was evaluated by scintigraphy. RESULTS: Surprisingly, several of the nonautotransplanted patients showed scintigraphic activity, indicating the presence of either accessory spleens or traumatic seeding (splenosis). Significant antibody titer increases (more than twofold) were found for both IgM and IgG in the autotransplanted patients. Splenectomized-only patients showed no significant increase in Ig levels in patients without splenic regrowth and partial improvement in patients with splenosis/accessory spleens. CONCLUSIONS: Considering this significant antipneumococcal antibody increase, spleen autotransplants can be expected to permit an adequate humoral response to pneumococcal infections and presumably also to other TI-2 antigens, and to protect against overwhelming postsplenectomy infection or sepsis.  (+info)

Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle. (3/1406)

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 +/- 3 to 20 +/- 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 +/- 0.79 vs. 4.79 +/- 0.73 l. min-1. m-2) and muscle perfusion (4.07 +/- 0.44 vs. 5.18 +/- 0.36 ml. 100 g-1. min-1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 +/- 0.06 vs. 0.48 +/- 0.03 ml O2. 100 g-1. min-1). Nevertheless, tissue PO2 was preserved (27.4 +/- 1.3 vs. 29.9 +/- 1. 4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 +/- 2.2 vs. 13.9 +/- 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.  (+info)

Implementing a policy for pneumococcal prophylaxis in a haematology unit after splenectomy. (4/1406)

People who have had a splenectomy for any reason are 40 times more likely to have an overwhelming infection, especially pneumococcal infection, and 17 times more likely to suffer fatal sepsis. The incidence of such life threatening infections is reduced by prophylactic immunisation with polyvalent pneumococcal vaccine and long term antibiotic prophylaxis or instituting prompt antibiotic treatment in the event of fever. This haematology unit agreed a policy of immunisation and antibiotic prophylaxis in June 1988 for all patients undergoing elective splenectomy. The success of this policy was audited in July 1993 by a retrospective analysis of patients' case notes. Seventy four patients were identified as having had a splenectomy, 54 (73%) before June 1988, of whom only 13 (24%) had received both pneumococcal immunisation and antibiotic prophylaxis before implementation of the agreed policy. At the time of audit, 46/74 (62%) patients were recorded as having received immunisation and 64/74 (86%) as receiving antibiotic prophylaxis or a supply of antibiotics to take in the event of a fever. All but one of the 20 patients who had a splenectomy after June 1988, since implementation of the agreed policy, received immunisation and antibiotic prophylaxis. The authors conclude that establishment of a formal agreed policy for pneumococcal prophylaxis for patients undergoing splenectomy has improved the quality of care.  (+info)

Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group. (5/1406)

Controversy still exists on the optimal surgical resection for potentially curable gastric cancer. Much better long-term survival has been reported in retrospective/non-randomized studies with D2 resections that involve a radical extended regional lymphadenectomy than with the standard D1 resections. In this paper we report the long-term survival of patients entered into a randomized study, with follow-up to death or 3 years in 96% of patients and a median follow-up of 6.5 years. In this prospective trial D1 resection (removal of regional perigastric nodes) was compared with D2 resection (extended lymphadenectomy to include level 1 and 2 regional nodes). Central randomization followed a staging laparotomy. Out of 737 patients with histologically proven gastric adenocarcinoma registered, 337 patients were ineligible by staging laparotomy because of advanced disease and 400 were randomized. The 5-year survival rates were 35% for D1 resection and 33% for D2 resection (difference -2%, 95% CI = -12%-8%). There was no difference in the overall 5-year survival between the two arms (HR = 1.10, 95% CI 0.87-1.39, where HR > 1 implies a survival benefit to D1 surgery). Survival based on death from gastric cancer as the event was similar in the D1 and D2 groups (HR = 1.05, 95% CI 0.79-1.39) as was recurrence-free survival (HR = 1.03, 95% CI 0.82-1.29). In a multivariate analysis, clinical stages II and III, old age, male sex and removal of spleen and pancreas were independently associated with poor survival. These findings indicate that the classical Japanese D2 resection offers no survival advantage over D1 surgery. However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial.  (+info)

Western immunoblot analysis of the antigens of Haemobartonella felis with sera from experimentally infected cats. (6/1406)

Cats were experimentally infected with a Florida isolate of Haemobartonella felis in order to collect organisms and evaluate the immune response to H. felis. Cryopreserved organisms were thawed and injected intravenously into nonsplenectomized and splenectomized cats. Splenectomized animals were given 10 mg of methylprednisolone per ml at the time of inoculation. Blood films were evaluated daily for 1 week prior to infection and for up to 60 days postinfection (p. i.). Blood for H. felis purification was repeatedly collected from splenectomized animals at periods of peak parasitemias. Organisms were purified from infected blood by differential centrifugation, separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and transferred to nitrocellulose membranes for immunoblot analysis. Serum was collected from nonsplenectomized animals prior to and for up to 60 days p.i. and was used on immunoblots to identify antigens. The combination of splenectomy and corticosteroid treatment resulted in marked, cyclic parasitemias without concurrent severe anemia, providing an opportunity to harvest organisms in a manner that was not lethal to the animals. Several antigens (150, 52, 47, 45, and 14 kDa) were identified. An antigen with a molecular mass of approximately 14 kDa appeared to be one of the most immunodominant and was consistently recognized by immune sera collected at various times during the course of infection. These data suggest that one or more of these antigens might be useful for the serologic diagnosis of H. felis infections in cats.  (+info)

Total gastrectomy with simultaneous pancreaticosplenectomy or splenectomy in patients with advanced gastric carcinoma. (7/1406)

A splenectomy or distal pancreaticosplenectomy is often performed simultaneously with total gastrectomy in the treatment of gastric carcinoma to facilitate dissection of the lymph nodes around the splenic artery and splenic hilus. However, the negative impact of splenectomy and pancreaticosplenectomy has also been reported. A retrospective analysis was performed to evaluate the outcomes of distal pancreaticosplenectomy and total gastrectomy, splenectomy and total gastrectomy, and gastrectomy alone in the patients with advanced gastric carcinoma without distant metastasis. Prognostic factors were examined. No significant differences existed in 5-year survival in the patients who underwent gastrectomy with splenectomy, gastrectomy with distal pancreaticosplenectomy, or gastrectomy alone. Neither splenectomy, nor distal pancreaticosplenectomy were prognostic factors. However, distal pancreaticosplenectomy was an independent predictor of pancreatic fistula. In conclusion, the addition of distal pancreaticosplenectomy or splenectomy to total gastrectomy for gastric cancer increases the risk of severe complications, but does not improve survival.  (+info)

Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. (8/1406)

Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder in which patients with poor prognostic features, receiving conventional treatments, have a median survival of less than 3 years. In this retrospective multicenter study, we analyze the results and try to define the indications for allogeneic stem cell transplantation in AMM. From January 1979 to November 1997, 55 patients with a median age of 42 years were transplanted from HLA-matched related (n = 49) or alternative (n = 6) donors for AMM. A multivariate analysis was conducted to identify factors associated with posttransplant outcome. The median posttransplant follow-up was 36 months (range, 6 to 223). The 5-year probability of survival was 47% +/- 8% for the overall group, and 54% +/- 8% for patients receiving an unmanipulated HLA-matched related transplant. The 1-year probability of transplant-related mortality was 27% +/- 6%. Hemoglobin level +info)

Splenectomy and thrombosis: The case of thalassemia intermediaSplenectomy and thrombosis: The case of thalassemia intermedia
Background: Hypercoagulability in splenectomized patients with thalassemia intermedia (TI) has been extensively evaluated. However, clinical and laboratory characteristics of patients who eventually develop overt thromboembolic events (TEE) are poorly studied. Patients-Methods: Three Groups of TI patients (n = 73 each) were retrospectively identified from a registry involving six centers across the Middle East and Italy: Group I, all splenectomized patients with a documented TEE; Group II, age- and sex-matched splenectomized patients without TEE; and Group III, age- and sex-matched nonsplenectomized patients without TEE. Retrieved data included demographics, laboratory parameters, clinical complications, and received treatments that may influence TEE development, and reflected the period prior to TEE occurrence in Group I. Results: The mean age of Group I patients at development of TEE was 33.1 ± 11.7 years, with a male to female ratio of 33:40. TEE were predominantly venous (95percent) while ...
https://scholarworks.aub.edu.lb/handle/10938/16938
Journal of Paediatric Surgeons of BangladeshJournal of Paediatric Surgeons of Bangladesh
p,,strong,Background:,/strong, Total splenectomy, exposes children to the high risk of overwhelming postsplenectomy infections (OPSI). To avoid these adverse consequences, partial splenectomy has long been practiced for thalasseemia in children. It has been reported that the partial splenectomy keeps the child immunologically competent, hematologically stable with minimum blood transfusion and makes their life more comfortable in comparison to total splenectomy.,/p,,p,,strong,Objectives:,/strong, To compare the results of partial and total splenectomy.,/p,,p,,strong,Methodology:,/strong, This prospective interventional comperative study was done in the department of Pediatric Surgery, BSMMU from 2010 to 2012. Children who underwent partial splenectomy were considered as the case and who underwent total splenectomy as the control. Number of blood (RCC) transfusions (ml/ kg/year), Peripheral blood film (Hb%, WBC count, platelet count, Howell-Jolly body, serum bilirubin), volume of liver (ml), ...
https://banglajol.info/index.php/JPSB/gateway/plugin/WebFeedGatewayPlugin/rss
THE INTOXICATION OF SPLENECTOMIZED MICE BY FEEDING FRESH SPLEEN AND OTHER ORGANS | Journal of Experimental Medicine |...THE INTOXICATION OF SPLENECTOMIZED MICE BY FEEDING FRESH SPLEEN AND OTHER ORGANS | Journal of Experimental Medicine |...
The intoxication which is developed when splenectomized mice are fed with fresh spleen is more regular in occurrence when the feeding experiment is carried out four or five days after splenectomy than when it is done at later periods. The intoxication is easily recognizable even in its less severe forms by a lengthening of the coagulation time of the blood. An intoxication of the same character is produced when splenectomized mice are fed with the mucous membrane of the stomach and upper small intestine. Bone marrow and dried blood probably give the same reaction in a somewhat milder form. The other organs either give no intoxication at all when fed, or in certain instances the thyroid, adrenal, and salivary gland (mouse) give intoxications of a different character which affect intact mice and splenectomized animals equally. The spleen or the gastro-intestinal mucosa is equally effective in producing the intoxication, whether it be derived from heterologous or homologous species. Certain ...
https://rupress.org/jem/article-standard/22/3/347/8624/THE-INTOXICATION-OF-SPLENECTOMIZED-MICE-BY-FEEDING
THE INTOXICATION OF SPLENECTOMIZED MICE BY FEEDING FRESH SPLEEN AND OTHER ORGANS | JEMTHE INTOXICATION OF SPLENECTOMIZED MICE BY FEEDING FRESH SPLEEN AND OTHER ORGANS | JEM
The intoxication which is developed when splenectomized mice are fed with fresh spleen is more regular in occurrence when the feeding experiment is carried out four or five days after splenectomy than when it is done at later periods. The intoxication is easily recognizable even in its less severe forms by a lengthening of the coagulation time of the blood.. An intoxication of the same character is produced when splenectomized mice are fed with the mucous membrane of the stomach and upper small intestine. Bone marrow and dried blood probably give the same reaction in a somewhat milder form. The other organs either give no intoxication at all when fed, or in certain instances the thyroid, adrenal, and salivary gland (mouse) give intoxications of a different character which affect intact mice and splenectomized animals equally.. The spleen or the gastro-intestinal mucosa is equally effective in producing the intoxication, whether it be derived from heterologous or homologous species.. Certain ...
http://jem.rupress.org/content/22/3/347
Laparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertensionLaparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertension
|p| To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splenectomy and porto-azygos devascularization operation time was 2.56 + 0.62 hours. The intraoperative bleeding and anal exhaust time was 149.5 + 32.7ml 3.47 + 1.32 days, and the hospitalization time was 5.05 + 1.22 days. When the spleen volume was greater than or equal to 1.5 liters, the rate of open abdominal surgery increased significantly. After 1, 2, 3, and 4 years of follow-up, cumulative recurrence bleeding rates were 0, 5.20%, 9.98%, and 15.83%, respectively. Laparoscopic splenectomy and pericardial devascularization is safe, effective, and feasible, and it can be confirmed by enhanced spiral computed tomography (CT). Whether spleen volume greater than 1.5L is suited to laparoscopic
https://www.infona.pl/resource/bwmeta1.element.-psjd-doi-10_1515_med-2015-0073
Laparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertension - Open...Laparoscopic splenectomy and porto-azygos disconnection: clinical research in the treatment of portal hypertension - Open...
To investigate the safety and efficacy of laparoscopic splenectomy and portaazygous devascularization, we studied laparoscopic splenectomy and porto-azygos devascularization patients within the peri-operative period. Clinical data and curative effect are detailed alongside statistical analysis. The laparoscopic splenectomy and porto-azygos devascularization operation time was 2.56 + 0.62 hours. The intraoperative bleeding and anal exhaust time was 149.5 + 32.7ml 3.47 + 1.32 days, and the hospitalization time was 5.05 + 1.22 days. When the spleen volume was greater than or equal to 1.5 liters, the rate of open abdominal surgery increased significantly. After 1, 2, 3, and 4 years of follow-up, cumulative recurrence bleeding rates were 0, 5.20%, 9.98%, and 15.83%, respectively. Laparoscopic splenectomy and pericardial devascularization is safe, effective, and feasible, and it can be confirmed by enhanced spiral computed tomography (CT). Whether spleen volume greater than 1.5L is suited to ...
http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.-psjd-doi-10_1515_med-2015-0073
Effect of Splenectomy on Red Cell Production | Annals of Internal Medicine | American College of PhysiciansEffect of Splenectomy on Red Cell Production | Annals of Internal Medicine | American College of Physicians
In hereditary spherocytosis and in some cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production. In these conditions the immediate effect of splenectomy on red cell production is usually obscured by preoperative transfusions or by autotransfusions from the surgically manipulated spleen. The resulting increase in hemoglobin concentration would be expected to cause a prompt decrease in erythropoietic activity. In two recent cases, one of a patient with hereditary spherocytosis and the other of a patient ...
https://annals.org/aim/article-abstract/681843/effect-splenectomy-red-cell-production
Laparoscopic splenectomy: Consensus and debatable pointsLaparoscopic splenectomy: Consensus and debatable points
MOHAMMED N, Bani Hani. et al. Laparoscopic splenectomy: Consensus and debatable points. S. Afr. j. surg. [online]. 2010, vol.48, n.3, pp.81-84. ISSN 2078-5151.. INTRODUCTION: The emergence of minimally invasive techniques has broadened interest in splenectomy for a variety of haematological illnesses. Laparoscopic splenectomy (LS) is currently considered the gold standard for the treatment of various haematological disorders. PURPOSE: The literature was reviewed to highlight points of consensus and debatable points regarding best practice in LS, looking at issues such as bleeding and conversion, splenomegaly, splenic retrieval techniques, types of instruments used, hand-assisted LS (HALS), complications, approaches, accessory spleen and splenosis. Our goal was to share our experience with LS and compare it with other reports. BACKGROUND: LS has emerged as the standard of care for elective splenectomy for benign haematological diseases. However, doubts have been raised regarding the suitability ...
http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0038-23612010000300003&lng=es&nrm=iso
The value of prophylactic vaccinations and antibiotic treatment in pos | TRRMThe value of prophylactic vaccinations and antibiotic treatment in pos | TRRM
The value of prophylactic vaccinations and antibiotic treatment in post-splenectomy patients: a review AJ Jolanda LammersDepartment of Infectious diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The NetherlandsAbstract: Although spleen preservation surgery and non-operative management are first-line treatment options, total splenectomy is frequently performed. Splenectomy is performed for a number of indications including idiopathic thrombocytopenic purpura, high-energetic trauma, and hematological malignancy. Following splenectomy, patients are at risk for overwhelming post-splenectomy infection (OPSI), a syndrome that presents with mild symptoms at onset but irreversible multi-organ-failure occurs within hours to days. Since the spleen plays an important role in the immune response to polysaccharide antigens, encapsulated bacteria such as pneumococci are the most frequently described causative organisms of OPSI. Although the incidence of OPSI is low, the associated mortality
https://www.dovepress.com/the-value-of-prophylactic-vaccinations-and-antibiotic-treatment-in-pos-a10246
Nplate Approved for Chronic ITP, NEXUS Program Launched : Oncology TimesNplate Approved for Chronic ITP, NEXUS Program Launched : Oncology Times
The FDA has approved Nplate (romiplostim) for the treatment of thrombocytopenia in splenectomized and non-splenectomized adults with chronic immune thrombocytopenic purpura (ITP).. In two Phase III studies of the drug, which works by raising and sustaining platelet counts, the overall response rate for romiplostim was 79% in splenectomized patients and 88% in non-splenectomized patients. Platelet counts were raised and sustained in the six-month studies, and patients were able to reduce or discontinue their use of concomitant ITP medications and emergency medications.. Nplates manufacturer, Amgen, also announced that it is launching the Nplate NEXUS (Network of Experts Understanding and Supporting Nplate and Patients) Program, to provide comprehensive access, support, and education for chronic ITP patients and their caregivers, and health care providers. The program is part of the Risk Evaluation and Mitigation Strategy developed by Amgen in partnership with the FDA to assure safe use of ...
https://journals.lww.com/oncology-times/Fulltext/2008/10100/Nplate_Approved_for_Chronic_ITP,_NEXUS_Program.13.aspx
Influence of splenectomy on intravenously induced and spontaneous meta by B Boeryd and B HagmarInfluence of splenectomy on intravenously induced and spontaneous meta by B Boeryd and B Hagmar
Boeryd, B and Hagmar, B, Influence of splenectomy on intravenously induced and spontaneous metastases in mice. (1969). Subject Strain Bibliography 1969. 418 ...
https://mouseion.jax.org/ssbb1969/418/
GCSSG-SPNX: Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: JCOG0110 - Full Text View -...GCSSG-SPNX: Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: JCOG0110 - Full Text View -...
European clinical trials of gastrectomy showed that splenectomy is an important risk factor for post-operative morbidity and mortality. Retrospective comparisons suggested that splenectomy is associated with poor long term survival. However, Japanese studies revealed that 20 - 30 % of patients with non-early carcinoma in the proximal stomach have nodal metastasis in the splenic hilum and therefore, pancreas-preserving splenectomy is part of the standard operation in specialized centers where splenectomy is not considered a risk factor for operative mortality. There have been no prospective randomized trials to evaluate the survival benefit of splenectomy in total gastrectomy for proximal gastric cancer.. Comparison: Total gastrectomy with pancreas-preserving splenectomy versus total gastrectomy without splenectomy ...
https://www.clinicaltrials.gov/ct2/show/study/NCT00112099?view=results
Splenectomy in Patients with Hematological Disorders - Our ExperienceSplenectomy in Patients with Hematological Disorders - Our Experience
|p||p||bold|The aim of the study.|/bold| Retrospective analysis of indications for splenectomy in hematological diseases, positive effect of this operation and correlations between objective prognostic factors and good response to splenectomy in patients with different hematological indications for splenectomy.|/p||p||bold|Material and methods.|/bold| 98 adult patients with hematological disorders, who were splenectomised in the years 1994 - 2004. We evaluated the effects of splenectomy in patients with hematological diseases as defined by patient documentation from the 2|sup|nd|/sup| Department of General and Oncological Surgery, Department of Hematology and Hematological Ambulance and the questionnaires that patients completed by themselves.|/p||p||bold|Results.|/bold| The beneficial effect of splenectomy was observed in the majority of cases of idiopathic thrombocytopenic purpura (41 of 53 patients), acquired hemolytic anemia (2 of 3 patients) and hereditary spherocytosis (8 of 9
https://www.infona.pl/resource/bwmeta1.element.-psjd-doi-10_2478_v10035-007-0066-y
Use of intravenous anti-D in patients with refractory and relapsed imm by R. Sajid, Salman Adil et al.Use of intravenous anti-D in patients with refractory and relapsed imm by R. Sajid, Salman Adil et al.
Objective: To determine the response to IV anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi. Methods: A total of 23 patients with chronic ITP were treated with either anti-D or splenectomy as second line treatment. The patients were assessed for time to achieve a response to second line treatment, duration ofresponse and adverse events. Results: There were 12 patients in the anti-D group and 11 in the splenectomy group. The mean platelet count at presentation was 9,000/cumm. The mean age was 8.9 years and 13.0 years and the male to female ratio was 1:1 and 1:1.2 in anti-D and splenectomy group respectively. 54.5% of the patient in the anti-D group responded compared to 81.8% in the splenectomy group. Median time to achieve a response was 7 days in the anti-D group and 1 day in the splenectomy group. Mean time to relapse was 87.8 days in the anti-D group and 55.4 days in the splenectomy
https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/562/
Laparoscopic Splenectomy Surgery India,Price Splenectomy SurgeryLaparoscopic Splenectomy Surgery India,Price Splenectomy Surgery
Laparoscopic Splenectomy Surgery India,Price Splenectomy Surgery Delhi,Laparoscopic Splenectomy Surgery Cost In India Info On Cost Laparoscopic
https://wecareindia.com/laparoscopic-splenectomy-india/
Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. - Semantic ScholarSplenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. - Semantic Scholar
The Wiskott-Aldrich syndrome is an X-linked immunodeficiency disorder consisting of the triad of frequent infections, eczema, and profound thrombocytopenia. We evaluated the effects of splenectomy on hemostatic improvement and subsequent clinical course in 16 patients with the Wiskott-Aldrich syndrome. All 16 had an increase in platelet counts to at least 100,000 per cubic millimeter after splenectomy, with the mean increasing from 19,900 per cubic millimeter preoperatively to 262,700 per cubic millimeter after splenectomy. In addition, platelet size, which is characteristically small in this disease, also became normal. Survival after splenectomy correlated with the prophylactic use of antibiotics. Five of seven patients not taking prophylactic antibiotics died of sepis within 33 months of surgery. The mean survival of the nine patients maintained with prophylactic antibiotics, however, was at least 91.4 months, with six of these patients still alive an average of 11.0 years or more after splenectomy.
https://www.semanticscholar.org/paper/Splenectomy-in-the-management-of-the-thrombocytope-Lum-Tubergen/29586ccc4c09aa9e15a59672e1a63bfec19e45a2
Cost-effectiveness of a post-splenectomy registry for prevention of sepsis in the asplenic - DROCost-effectiveness of a post-splenectomy registry for prevention of sepsis in the asplenic - DRO
Method: The decision model compared a cohort of 1,000 people covered by a registry to a cohort of 1,000 people with no registry. The impact of the registry was assessed in terms of achieved rates of vaccination, chemoprophylaxis and education, consequent outcomes of overwhelming post-splenectomy infection (OPSI) and mortality (years of life lived). The cost-effectiveness of the registry compared with no registry was estimated in terms of additional cost per case of OPSI avoided and as additional cost per life year gained ...
http://dro.deakin.edu.au/view/DU:30009299
Current version of study NCT00336362 on ClinicalTrials.govCurrent version of study NCT00336362 on ClinicalTrials.gov
Primary Objective: To determine the safety of PBSC mobilization with G-CSF, with or without HU pretreatment in adults with beta thalassemia major.. Secondary Objective: To determine the number of CD34+ stem/progenitor cells that are mobilized under these conditions, as well as the ability of these cells to be transduced with a recombinant lentivirus vector for beta-globin and engraft immunodeficient mice.. Study Design: The ability of G-CSF to safely and effectively mobilize PBSC in adults with beta thalassemia major will be assessed in 12 splenectomized and 12 non-splenectomized patients. Of the 12 splenectomized patients, 6 will be treated with HU and G-CSF, and 6 will be treated only with G-CSF. Likewise, of the 12 non-splenectomized patients, 6 will be treated with HU and G-CSF, and 6 will be treated only with G-CSF. G-CSF mobilized participants will undergo leukapheresis on 2 consecutive days, with a target yield of 2 million CD34+ cells per kg of body weight. Safety will be assessed by ...
https://www.clinicaltrials.gov/show/NCT00336362
Amgen - Investors - Press ReleaseAmgen - Investors - Press Release
Pivotal Phase 3 Romiplostim Study in Splenectomized Patients Meets Primary Endpoints Data Show Romiplostim Increased and Sustained Platelet Counts in Splenectomized Adult Patients with Immune Thrombocytopenic Purpura ATLANTA--(BUSINESS WIRE)--Dec. 8, 2007--Amgen Inc. (NASDAQ:AMGN) today announced results from a randomized, pivotal Phase 3 study that showed romiplostim (AMG 531) increased and sustained platelet counts in splenectomized (spleen removed) adult patients with chronic Immune Thrombocytopenic Purpura (ITP). Additionally, romiplostim-treated patients taking concurrent ITP medications such as corticosteroids were able to reduce or discontinue these medications. Adult ITP is a serious chronic autoimmune disorder characterized by low platelet counts in the blood, a condition known as thrombocytopenia. These Phase 3 data will be presented in a Plenary Session at the American Society of Hematology (ASH) 49th Annual Meeting in Atlanta, GA (Abstract #2).. The majority of available therapies ...
http://investors.amgen.com/phoenix.zhtml?c=61656&p=irol-newsArticle&ID=1085372
Splenectomy does not cure the thrombocytopenia of systemic lupus erythematosus<...
TY - JOUR. T1 - Splenectomy does not cure the thrombocytopenia of systemic lupus erythematosus. AU - Hall, S.. AU - McCormick, J. L.. AU - Greipp, P. R.. AU - Michet, C. J.. AU - McKenna, C. H.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Fourteen patients with systemic lupus erythematosus had splenectomies done between 1960 and 1982 for treatment of severe thrombocytopenia. Thrombocytopenia persisted or recurred within 1 month postoperatively in five patients and within 6 months in three others. Three patients had late recurrence (18, 30, and 54 months after splenectomy); in two cases it was probably related to withdrawal of immunosuppressive agents or corticosteroids. Median lowest platelet count before splenectomy and median platelet count at relapse or failure of splenectomy were both 8000/μL. Only two patients maintained normal platelet counts without need for corticosteroids or other treatment. These results differ from those in patients with idiopathic thrombocytopenic purpura. Other treatments ...
https://mayoclinic.pure.elsevier.com/en/publications/splenectomy-does-not-cure-the-thrombocytopenia-of-systemic-lupus-
Splenectomy for Hematologic Disease: A 10 Year Review - SAGES Abstract ArchivesSplenectomy for Hematologic Disease: A 10 Year Review - SAGES Abstract Archives
Background: Laparoscopic splenectomy (LS) has been established as a safe and effective alternative to open splenectomy (OS) for the treatment of appropriate patients with hematologic disease. The purpose of this study was to review our teaching institutions experience with splenectomy for hematologic disease.. Methods: Between 1996 and 2005 a total of 101 consecutive splenectomies were performed for both benign (53) and malignant (48) hematologic diseases by a single surgeon. These cases were reviewed for their post-operative outcomes, with particular attention to surgical approach (LS vs. OS), conversions, and complications. Results: 61% of patients underwent planned LS, with a 79% success rate. Patients with malignant disease were significantly older (p< 0.005), had larger spleens (p< 0.007), (40 cases of splenomegaly), more likely to undergo OS (p< 0.0009, 13 attempted LS, 62% success rate), and had longer length of stay (p< 0.02). However, there was no significant difference in OR time, ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/splenectomy-for-hematologic-disease-a-10-year-review/
Laparoscopic Splenectomy by Jeffrey C. Pence and Keith T. OldhamLaparoscopic Splenectomy by Jeffrey C. Pence and Keith T. Oldham
The elucidation of splenic function in health and disease has been continuously evolving since Aristotle dismissed the concept that it is essential for human existence more than 2000 years ago. The first recorded splenectomy was performed by Zaccarelli in 1549 for presumed malaria in a young woman who survived at least 6 years postoperatively [1]. The nonessential nature of the spleen was reinforced in subsequent animal experimentation following Reads successful splenectomy in a dog in 1638 [2]. Quittenbaum [3], in 1826, is credited with the initial well-documented splenectomy in a young woman with probable portal hypertension and splenomegaly. The patient expired postoperatively from exsanguination. Despite this dismal early outcome, splenectomy became an acceptable practice for idiopathic hypertrophy, malarial hypertrophy, splenic anemia, leukemia, cysts, and tuberculosis, with an associated mortality rate of 13% by 1908 [4].
https://corescholar.libraries.wright.edu/surg/670/
The spleen is an intraperitoneal organ that performs vital hematological and immunological functions | the effects of VD3...The spleen is an intraperitoneal organ that performs vital hematological and immunological functions | the effects of VD3...
The spleen is an intraperitoneal organ that performs vital hematological and immunological functions. which is defined as a generalized non-specific flu-like prodrome followed by rapid deterioration to full-blown fulminant septic Tmem1 shock within 24-48 hours of the onset [9]. Although there is no specific diagnostic criterion for OPSI, prompt identification followed by proper management can prevent further deterioration and fatality [25]. The prevalence of OPSI following splenectomy is 0.1-0.5%, with a mortality rate of up to 50% [26]. The period of?highest risk for infections is during the first 3 years post-splenectomy; however, the risk Saxagliptin (BMS-477118) remains elevated throughout an individuals lifespan, indicated by the reported occurrence of cases of fulminant infection 20 years after splenectomy?[6]. Children under 2-5 years of age, those who have had splenectomy post-trauma, individuals splenectomized for hematological malignancy or malignant conditions, and immunosuppressed or ...
http://naturalistes-st-lupicin.com/%EF%BB%BFthe-spleen-is-an-intraperitoneal-organ-that-performs-vital-hematological-and-immunological-functions/
Akademik Gastroenteroloji Dergisi
Overwhelming postsplenectomy infection is a rare but serious disease that can occur after splenectomy. It is important for physicians to be familiar with it since delayed diagnosis or inadequate treatment causes high mortality. The objective of this article is to heighten awareness of physicians regarding this disease through a case report. Here we present a 70-year-old male patient who had a splenectomy for myelofibrosis. He developed recurrent upper respiratory and skin infections after splenectomy. Eventually, he died due to severe multisystem infection and having sepsis for six months postoperatively despite aggressive resuscitation and treatment. Rapid identification of patients at risk for the disease and early treatment may be the only chance to reduce the high mortality rate of this disease.. ...
http://akademik.tgv.org.tr/makale.php?mid=593
Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus...Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus...
TY - JOUR. T1 - Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis. AU - Masuya, Masahiro. AU - Shiraki, Katsuya. AU - Sugimoto, Kazushi. AU - Yamamoto, Norihiko. AU - Yoneda, Misao. AU - Kanayama, Kazuki. AU - Nishikawa, Kenichiro. AU - Ino, Kazuko. AU - Tawara, Isao. AU - Ohishi, Kohshi. AU - Sakurai, Hiroyuki. AU - Usui, Masanobu. AU - Shiraishi, Taizo. AU - Isaji, Shuji. AU - Takei, Yoshiyuki. AU - Katayama, Naoyuki. N1 - Publisher Copyright: © 2014 The Japan Society of Hepatology.. PY - 2014/12/1. Y1 - 2014/12/1. N2 - Aim: The spleen is not believed to contribute to hematopoiesis in healthy adults. However, several reports have demonstrated that the spleen in adults contains a large number of hematopoietic stem/progenitor cells (HSC). Although splenectomy increases platelet and leukocyte counts, the effects of splenectomy on circulating HSC have not been elucidated. In this study, we evaluated ...
https://pure.fujita-hu.ac.jp/en/publications/splenectomy-increases-the-number-of-circulating-hematopoietic-ste
A case of isolated diffuse splenic haemangiomatosis in a dog | Veterinary Record Case Reports
This report describes a case of isolated diffuse haemangiomatosis in the spleen of a nine-month-old dog that presented with weakness, abdominal discomfort and severe splenomegaly. Histopathological examination following splenectomy showed the splenic parenchyma had almost been replaced by multiple dilated vascular lacunae, varying is size, and lined by a single layer of flattened, well differentiated, endothelial cells sustained by fine fibrocystic bundles. The cytoplasmic expression of CD34 and von Willebrand factor found in the endothelial cells confirmed the vascular nature of the lesion; the lack of expression of podoplanin, a specific marker for the lymphatic vessels, excluded the diagnosis of lymphangiomatosis. Diffuse splenic haemangiomatosis carries a benign prognosis and complete cure following splenectomy has been described in humans and was achieved in this case. However, the differential diagnosis must take into account the possibility of vascular malignant or tumour-like lesions ...
http://vetrecordcasereports.bmj.com/content/3/1/e000160
The Post Splenectomy Blood Picture - ProPathThe Post Splenectomy Blood Picture - ProPath
The diagnosis of a post-splenectomy/hyposplenic blood picture can be made reliably by identifying Howell Jolly bodies in routine Wright-Giemsa stained blood. These are round basophilic bodies in red blood cells that represent residual nuclear material from marrow nucleated red cell precursors that are usually culled out by the spleen (Fig 1, Table 1). These do not occur in individuals with normally functioning splenic tissue and their presence indicates either 1) an asplenic state or 2) hypofunctioning splenic tissue as might be seen in a patient with late-stage sickle cell anemia. Their presence in an individual with splenomegaly leads to a narrow differential diagnosis (Table 2) and their absence in a splenectomized individual indicates accessory splenic Heinz bodies and poikilocytosis typically increase in a splenectomized individual and care must be taken not to overdiagnose hemolysis in such an individual. Benign poikilocytosis can be quite dramatic in an asplenic individual with renal ...
https://propath.com/the-post-splenectomy-blood-picture/
Abdominal Venous Thrombosis Following Splenectomy: A Critical Review of our Standard Aftercare Protocol - Digital Poster...
Digitale Posterpräsentation der Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Thoraxchirurgie im Rahmen des DACH-Kongress 2015.
http://www.chirurgiekongress-poster.ch/posters/abdominal_venous_thrombosis_following_splenectomy_a_critical_review_of_our_standard_aftercare_proto/
Cause for polydipsia in dog following splenectomy? - Questions & Answers | VetInfo/QACause for polydipsia in dog following splenectomy? - Questions & Answers | VetInfo/QA
Please do not use our site to attempt to diagnose or treat your pet. Your veterinarian is the best source of health advice for an individual pet. Please do use our site to become better informed about the medical problems your pet may have. We will do our best to ensure that information presented is accurate and up-to-date. The most current information will be at the top of each page. Remember that veterinarians often disagree about the best treatments for pets. There are often several perfectly acceptable ways to treat the same condition. Just ask a lot of questions! For all emergency situations, please contact your local Emergency Pet Clinic or on-call Veterinarian. Answers are not provided in real time. We can not guarantee an answer to every question, nor can we provide timely responses to urgent questions in many instances. ...
https://www.vetinfo.com/vets/answers/cause-for-polydipsia-in-dog-following-splenectomy
Splenectomy facts, information, pictures | Encyclopedia.com articles about Splenectomy
Get information, facts, and pictures about Splenectomy at Encyclopedia.com. Make research projects and school reports about Splenectomy easy with credible articles from our FREE, online encyclopedia and dictionary.
https://www.encyclopedia.com/medicine/divisions-diagnostics-and-procedures/medicine/splenectomy
Asplenia Morning Report January 12, 2010 Lindsay Kruska. - ppt downloadAsplenia Morning Report January 12, 2010 Lindsay Kruska. - ppt download
26 References Hoffman. Hematology: Basic Principles and Practices, 5 th ed. Hoffman. Hematology: Basic Principles and Practices, 5 th ed. Keane. Nadas Pediatric Cardiology. 2 nd ed. Keane. Nadas Pediatric Cardiology. 2 nd ed. UTDOL. Jan 2010. UTDOL. Jan 2010. Patient knowledge of the risks of post-splenectomy sepsis. ANZ J Surg. 2008 Oct;78(10):867-70. Patient knowledge of the risks of post-splenectomy sepsis. ANZ J Surg. 2008 Oct;78(10):867-70. Evaluation of severe infection and survival after splenectomy. Am J Med. 2006 Mar;119(3):276.1-7. Evaluation of severe infection and survival after splenectomy. Am J Med. 2006 Mar;119(3):276.1-7. ...
http://slideplayer.com/slide/3352228/
Effects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly MiceEffects of Splenectomy on Spontaneously Chronic Pancreatitis in aly/aly Mice
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
https://www.hindawi.com/journals/jir/2010/614890/
Infectious DiseaseInfectious Disease
Infectious Disease is a chapter in the book, Gastroenterology, containing the following 23 pages: Diverticulitis, Spontaneous Bacterial Peritonitis, Campylobacter jejuni, Vibrio Cholera, Clostridium difficile, Escherichia coli, Salmonella, Typhoid Fever, Shigella, Yersinia enterocolitica, Entamoeba histolytica, Cryptosporidium parvum, Giardia lamblia, Norovirus, Rotavirus, Liver Abscess, Pancreatic Abscess, Helicobacter Pylori, Overwhelming Postsplenectomy Infection, Viral Gastroenteritis, Listeria monocytogenes, Enterohemorrhagic E. coli, Cyclospora.
http://www.fpnotebook.com/GI/ID/index.htm
Best Splenectomy Doctor in Delhi NCR, Splenectomy Doctors | CredihealthBest Splenectomy Doctor in Delhi NCR, Splenectomy Doctors | Credihealth
Find the best splenectomy doctors in Delhi NCR. Get guidance from medical experts to select splenectomy specialist in Delhi NCR from trusted hospitals - credihealth.com
https://www.credihealth.com/doctors/delhi-ncr/splenectomy
Management of immune thrombocytopenia: Korean experts recommendation in 2017Management of immune thrombocytopenia: Korean experts recommendation in 2017
Splenectomy: For decades, surgical splenectomy was the treatment of choice; however, recent data suggest that less than 30% of patients with ITP undergo splenectomy [32], despite long-term response rates of 60-70% [3334]. Risk of infection (5- to 30-fold increase in the first 90 days and 1- to 3-fold life-long increased risk of invasive bacterial infection and sepsis), risk of thrombosis (,30-fold compared to the general population) as well as reports of pulmonary hypertension and immediate post-operative complications may have contributed to decreased splenectomy rates [343536]. Therefore, it is recommended to delay splenectomy for at least 6 months to one year after diagnosis even if splenectomy is considered as a useful second-line treatment [3].. According to the 1996 and 2011 ASH guidelines, further treatment of patients, with platelet counts ,30×109/L in the absence of bleeding who have failed to respond to splenectomy, is not recommended. However, further treatment was recommended for ...
http://www.bloodresearch.or.kr/journal/view.html?uid=2095&vmd=Full
SPLENECTOMY, LAPAROSCOPIC | Zollingers Atlas of Surgical Operations, 10e | AccessSurgery | McGraw-Hill MedicalSPLENECTOMY, LAPAROSCOPIC | Zollingers Atlas of Surgical Operations, 10e | AccessSurgery | McGraw-Hill Medical
Patients for elective splenectomy are usually referred to the surgeon by hematologists or oncologists, because their treatment with blood products, corticosteroids, plasmaphoresis, gamma globulins, or chemotherapy can no longer safely control the primary disease. Accordingly, the patient may require transfusion of blood products to raise the hematocrit or platelet counts to safe levels for general anesthesia and coagulation during surgery. Packed red cells may be given in advance of planned surgery, whereas platelets, with their short life span, may be infused just prior to and during the procedure. When platelet transfusions are contraindicated, endogenous platelet counts are often temporarily boosted with a few days of increased corticosteroid therapy, immune globulin or Rho D immune globulin (winrho) prior to surgery. If steroids are used, then they must be continued during and immediately after surgery. The patient should have a type and screening blood test, and blood products must be ...
http://accesssurgery.mhmedical.com/content.aspx?bookid=1755§ionid=119130143
THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE | JEMTHE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE | JEM
Our studies give evidence of increase in the iron elimination in three of five dogs during a period of two weeks following splenectomy, but not in two other dogs. The occasional increased output of iron may have some relation to the anemia which occurs in the early weeks after splenectomy and which varies in degree in different animals.. No evidence was secured of an increase in the iron output at 1, 9, and 20 months after splenectomy.. From our own studies and from examination of the literature of the subject, we conclude that the spleen does not exercise a constant and important influence upon the iron metabolism of the body.. ...
http://jem.rupress.org/content/20/2/122
10 Ways To Increase Platelet Count: Instantly Brilliant Approaches
Thrombocytopenia cases that are particularly resistant may require surgery called splenectomy, where the doctor removes the spleen from the body. Although the function of the spleen is not 100% understood, researchers show that it functions as a filter for the blood, and removes old red blood cells and platelets from the blood stream.. In some cases, the spleen becomes enlarged and stores more than the normal amount of what should only be taken from circulating platelets. This leads to thrombocytopenia. A splenectomy surgery is usually the most preferable low platelet count treatment option to cure the dysfunction; but, doctors generally tries first to use more conservative treatment options, considering that there is no way to undo splenectomy.. On average, splenectomies are successful for about 66 percent of the time. But, over time, it is still possible for thrombocytopenia to recur. People younger than 40 who have undergone splenectomy have a better chance to increase their number of ...
https://www.thrombocyte.com/how-to-increase-platelet-count/
Splenectomy | Leukemia and Lymphoma Society of CanadaSplenectomy | Leukemia and Lymphoma Society of Canada
A splenectomy is the procedure done to remove the spleen. Before effective drugs became available for hairy cell leukemia, splenectomy was the first-line treatment for the disease.
http://www.llscanada.org/leukemia/hairy-cell-leukemia/treatment/splenectomy
Successful rescue of refractory, severe antibody mediated rejection with splenectomy<...
TY - JOUR. T1 - Successful rescue of refractory, severe antibody mediated rejection with splenectomy. AU - Kaplan, Bruce. AU - Gangemi, Antonio. AU - Thielke, James. AU - Oberholzer, José. AU - Sankary, Howard. AU - Benedetti, Enrico. PY - 2007/1. Y1 - 2007/1. N2 - Antibody-mediated rejection (AMR) commonly occurs after transplantation of ABO-incompatible and sensitized renal transplant. Treatment regimens commonly include a combination of plasmapheresis (PL) and intravenous immunoglobulin (IVIG). However, some cases of AMR remain refractory to treatment. We report a case series of four patients with AMR refractory to standard therapy (ST) who resolved after splenectomy. Four living donor kidney transplant recipients were diagnosed with AMR. Two patients were ABO incompatible, one was cross-match positive and one had no obvious predisposing factors. After failure of therapy with corticosteroids, PL, IVIG, Thymoglobulin, and Rituximab (three patients) or Campath (one patient), AMR was treated ...
https://asu.pure.elsevier.com/en/publications/successful-rescue-of-refractory-severe-antibody-mediated-rejectio
Clinical updates in adult immune thrombocytopenia | Blood JournalClinical updates in adult immune thrombocytopenia | Blood Journal
At the time of the publication of the guidelines (2010-2011), there were little data available on the long-term safety and efficacy of many second-line therapies for ITP, in particular, for the TPO-RA. In part because of this, splenectomy was recommended in the ASH guidelines as second-line therapy for ITP with the recommendation to try to delay splenectomy to 6 months to 1 year after diagnosis.3 The International Consensus group on ITP listed additional alternatives to splenectomy as acceptable second-line therapies, however.4 For decades, surgical splenectomy was the treatment of choice; however, recent data suggest that ,25% of patients with ITP undergo splenectomy,64 despite 5-year response rates of 60% to 70%.65,66 Risk of infection (5- to 30-fold increase in the first 90 days and 1- to 3-fold life-long increased risk of invasive bacterial infection and sepsis), risk of thrombosis (,30-fold compared with the general population), as well as reports of pulmonary hypertension and immediate ...
http://www.bloodjournal.org/content/129/21/2829?sso-checked=true
Splenectomy | Heartland Womens GroupSplenectomy | Heartland Womens Group
Learn more about Splenectomy at Heartland Womens Group DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
https://heartlandwomensgroup.com/hl/?/14866/
Plus itPlus it
With acquisition of an ever increasing number of more or less specific therapeutic agents, splenectomy in leukemia has been performed infrequently in more recent years. There remains, however, a small group of leukemic patients who may be substantially benefited by splenectomy.. The result of splenectomy in 34 new patients is presented with a critical review of results obtained in a total of 299 cases collected from the literature.. The criteria for splenectomy in leukemia and myelofibrosis are: (a) Ineffectiveness of other forms of therapy to control cytopenia, particularly anemia in the presence of a splenomegaly when the anemia, or cytopenia in general, is sufficiently severe to be a major element of illness. In such a state, splenectomy must be conditioned on evidence, by study of the bone marrow and by determination of the rate of turnover of red cells, that the production of red cells is at least normal, preferably if it is increased. (b) Intractable pain, referable to the size of the ...
http://cancerres.aacrjournals.org/content/26/3_Part_1/519
Risk Factors in Myelofibrosis Linked With Poor Outcome After Splenectomy | Cancer Network | The Oncology JournalRisk Factors in Myelofibrosis Linked With Poor Outcome After Splenectomy | Cancer Network | The Oncology Journal
Survival of patients with myelofibrosis who undergo splenectomy is adversely affected by older age, the need for transfusion, and leukocyte and circulating blast cell counts, according to a new analysis. 1
http://www.cancernetwork.com/hematologic-malignancies/risk-factors-myelofibrosis-linked-poor-outcome-after-splenectomy
Spleen Removal Laparoscopic Splenectomy - Alternatives - MedSelfEd Patient Education Videos and PicturesSpleen Removal Laparoscopic Splenectomy - Alternatives - MedSelfEd Patient Education Videos and Pictures
Preop.com Patient Education is a comprehensive guide to medical surgery procedures online including videos, slide shows, pictures and other media-flexible content
http://som.medselfed.com/asp/prodDisplay.asp?prodId=356&secId=3&partnerId=som&id=&cachedate=&emailId=&affId=&campId=&hideNav=¢erId=lap
Spleen Removal Laparoscopic Splenectomy - Your Body - MedSelfEd Patient Education Videos and PicturesSpleen Removal Laparoscopic Splenectomy - Your Body - MedSelfEd Patient Education Videos and Pictures
Preop.com Patient Education is a comprehensive guide to medical surgery procedures online including videos, slide shows, pictures and other media-flexible content
http://svi.medselfed.com/asp/prodDisplay.asp?prodId=356&partnerId=svi&id=&cachedate=&emailId=&affId=&campId=&hideNav=
Autologous splenic transplantation in post-traumatic splenectomy - Minerva Chirurgica 1999 January-February;54(1-2):31-6 -...
Autologous splenic transplantation in post-traumatic splenectomy - Minerva Chirurgica 1999 January-February;54(1-2):31-6 - Minerva Medica - Journals
https://www.minervamedica.it/en/journals/minerva-surgery/article.php?cod=R06Y1999N01A0031
Augmented therapeutic results elicited by splenectomy in combined moda by R L. Stolfi, L M. Stolfi et al.Augmented therapeutic results elicited by splenectomy in combined moda by R L. Stolfi, L M. Stolfi et al.
Stolfi, R L.; Stolfi, L M.; Fugmann, R A.; and Martin, D S., Augmented therapeutic results elicited by splenectomy in combined modality treatment of spontaneous murine breast cancer. (1977). Subject Strain Bibliography 1977. 1065 ...
https://mouseion.jax.org/ssbb1977/1065/
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Your surgeon or dermatologist cialis cheap Find. And Russia cheap Find cialis for medical advice. A single polyp found during laparoscopic splenectomy are usually caused by repetitive stress injuries.
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Clinical and Hematologic Benefits of Partial Splenectomy for Congenital Hemolytic Anemias in Children<...
TY - JOUR. T1 - Clinical and Hematologic Benefits of Partial Splenectomy for Congenital Hemolytic Anemias in Children. AU - Rice, Henry E.. AU - Oldham, Keith T.. AU - Hillery, Cheryl A.. AU - Skinner, Michael A.. AU - OHara, Sara M.. AU - Ware, Russell E.. PY - 2003/2. Y1 - 2003/2. N2 - Objective: To assess the role of partial splenectomy for symptomatic children with various congenital hemolytic anemias. Summary Background Data: The use of total splenectomy for symptomatic children with congenital hemolytic anemias is restricted by concern of postsplenectomy sepsis. A partial splenectomy is an alternative procedure, although its utility remains incompletely defined. Methods: This longitudinal cohort study followed 25 symptomatic children with various congenital anemias who underwent partial splenectomy. Sixteen children had hereditary spherocytosis (HS), and nine children had other erythrocyte disorders. Outcome measures were clinical and laboratory hemolysis, splenic phagocytic and immune ...
https://utsouthwestern.pure.elsevier.com/en/publications/clinical-and-hematologic-benefits-of-partial-splenectomy-for-cong
Massive hepatomegaly following splenectomy for myeloid metaplasia<...Massive hepatomegaly following splenectomy for myeloid metaplasia<...
TY - JOUR. T1 - Massive hepatomegaly following splenectomy for myeloid metaplasia. AU - Grieco, Antonio. AU - Gambassi, Giovanni. AU - Manna, Raffaele. AU - Mancini, Rosalba. PY - 1988. Y1 - 1988. N2 - no abstract. AB - no abstract. KW - hepatomegaly. KW - myeloid metaplasia. KW - hepatomegaly. KW - myeloid metaplasia. UR - http://hdl.handle.net/10807/20968. M3 - Article. VL - 84. SP - 797. EP - 798. JO - American Journal of Medicine. JF - American Journal of Medicine. SN - 0002-9343. ER - ...
https://publires.unicatt.it/it/publications/massive-hepatomegaly-following-splenectomy-for-myeloid-metaplasia-9
Splenosis Following Splenectomy | JAMA Surgery | The JAMA NetworkSplenosis Following Splenectomy | JAMA Surgery | The JAMA Network
To the Editor.-A recent article1 on the incidence of residual splenic tissue following splenectomy for trauma described a 26% occurrence of splenosis. This is a
https://jamanetwork.com/journals/jamasurgery/article-abstract/590237?redirect=true
Palliative splenectomy in myelofibrosis with myeloid metaplasia<...
TY - JOUR. T1 - Palliative splenectomy in myelofibrosis with myeloid metaplasia. AU - Mesa, R. A.. AU - Tefferi, A.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Myelofibrosis with myeloid metaplasia (MMM) is a chronic myeloproliferative disorder in which the accumulation and growth of circulating myeloid progenitors in the spleen lead to pathologic enlargement of the organ with resulting mechanical discomfort, hypercatabolic symptoms, anemia, thrombocytopenia, and portal hypertension. Medical therapy and splenic irradiation may be of benefit in certain patients, yet many may still require splenectomy to palliate their symptoms. Although there is no clear survival advantage to splenectomy in MMM, the procedure can result in substantial palliation of symptoms. However, the surgical procedure is associated with an approximately 9% mortality rate, and the postsplenectomy occurrence of extreme thrombocytosis, hepatomegaly, and leukemic transformation is of major concern. The management of splenomegaly and the ...
https://mayoclinic.pure.elsevier.com/en/publications/palliative-splenectomy-in-myelofibrosis-with-myeloid-metaplasia
Splenectomy - Notes ReadSplenectomy - Notes Read
Splenectomy is part of the therapeutic arsenal in those hematological diseases where the spleen constitutes the predominant organ of destruction of the formed elements of the blood; in most cases, they are patients with immune thrombocytopenic purpura and hereditary spherocytosis. Sutherland, in 1910 it was he who first proposed splenectomy in the treatment of hereditary spherocytosis and Kuznelson in 1916 for thrombocytopenic purpura . From the first laparoscopic cholecystectomy performed in 1985 and after it became the gold standard for the treatment of gallstones.from the nineties on; The development of videolaparoscopic surgery has been rapid in the last decade. As the number of procedures performed increased, the experience of the surgeons also increased, and with it, the acquisition of the necessary training to perform other procedures of greater complexity (advanced laparoscopic surgery). Laparoscopic splenectomy was first performed in 1991 by Delaitre and Maignien and has gained ...
https://notesread.com/splenectomy/
First Experience of Single Port Accessory Splenectomy in Patient with Autoimmune Hemolytic Anemia. - SAGES Abstract ArchivesFirst Experience of Single Port Accessory Splenectomy in Patient with Autoimmune Hemolytic Anemia. - SAGES Abstract Archives
Laparoscopic splenectomy is widely accepted as a preferred surgical technique. Single port laparoscopic surgery further improves cosmesis, pain control and recovery compared to standard multi-port laparoscopy.. We report on a single port accessory splenectomy in patient with symptomatic recurrence of autoimmune hemolytic anemia after prior splenectomy more that 30 years ago. Patient was maintained on prednisone 30 mg daily preoperatively. Preoperative imaging localized accessory spleen to left upper quadrant area. With the use of SILS™ Port (Covidien) accessory spleen was identified in splenic fossa and removed. The later represented globular mass of 35 grams, 4.6 x 4.3 cm in diameter. Procedure lasted 80 minutes. Estimated blood loss was 30 ml. Postoperatively patient did well and was discharged on postoperative day three requiring only four Lortab tablets during hospital stay. During follow up patient is doing well, currently off steroids with hematocrit stabilized at 34 per cent.. We ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/first-experience-of-single-port-accessory-splenectomy-in-patient-with-autoimmune-hemolytic-anemia/
An audit of splenectomies in a teaching hospital in North India. Are postsplenectomy guidelines being complied with? | Journal...An audit of splenectomies in a teaching hospital in North India. Are postsplenectomy guidelines being complied with? | Journal...
The asplenic state is a health risk increasingly being recognised by health professionals all over the world. Infection in patients with an absent or dysfunctional spleen remains largely preventable. Many measures have been proposed to reduce the risk of sepsis after splenectomy, which include chemoprophylaxis, immunoprophylaxis, and patient/clinician education.6. Other than the known susceptibility of splenectomised individuals to encapsulated bacteria (Streptococcus pneumoniae, N meningitides, and H influenziae),7 there is evidence to suggest that other organisms, such as Gram negative bacteria and Capnocytophaga canimorsus,2 in addition to intraerythrocytic parasites, such as babesia and plasmodium, can cause infections and carry considerable morbidity.8. The pneumococcal vaccine, first introduced in the 1970s, presently includes 23 serotypes responsible for approximately 88% of pneumococcal infections. However, the most virulent pneumococcal serotypes tend to be the least immunogenic, and ...
http://jcp.bmj.com/content/57/4/407
Spleen-preserving lymphadenectomy versus splenectomy in laparoscopic total gastrectomy for advanced gastric cancer<...
TY - JOUR. T1 - Spleen-preserving lymphadenectomy versus splenectomy in laparoscopic total gastrectomy for advanced gastric cancer. AU - Son, Sang Yong. AU - Shin, Dong Joon. AU - Park, Young Suk. AU - Oo, Aung Myint. AU - Jung, Do Hyun. AU - Lee, Chang Min. AU - Ahn, Sang Hoon. AU - Park, Do Joong. AU - Kim, Hyung Ho. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Background To investigate the optimal approach for laparoscopic splenic hilum lymph node dissection in proximal advanced gastric cancer, we compared the operative outcomes between laparoscopic spleen-preserving total gastrectomy (sp-LTG) and laparoscopic total gastrectomy with splenectomy (sr-LTG). Methods A retrospective case-cohort study was conducted between February 2006 and December 2012. The operative outcomes, the number of retrieved splenic hilum lymph node, complication, and patients survivals were analyzed. Results 112 patients who underwent laparoscopic total gastrectomy with or without splenectomy for advanced gastric cancer were ...
https://koreauniv.pure.elsevier.com/en/publications/spleen-preserving-lymphadenectomy-versus-splenectomy-in-laparosco
Agnogenic myeloid metaplasia: role of splenectomy | Postgraduate Medical JournalAgnogenic myeloid metaplasia: role of splenectomy | Postgraduate Medical Journal
The splenomegaly associated with myelofibrosis and agnogenic myeloid metaplasia should not be considered a manifestation of the fundamental proliferative process, nor should it be considered as necessarily compensatory for reduced marrow haematopoiesis.. In deserving cases splenectomy may cause an improvement in the patients general and haematopoietic status. Removal of the source of functional hypersplenism, causing haemolytic episodes and thrombocytopenia, results in marked amelioration in the clinical condition with reduction in the magnitude and frequency of replacement blood transfusion.. The massive size of the spleen associated with this condition may not only cause local pain and discomfort but may lead to traumatic or spontaneous rupture.. Consideration of two cases studied by the authors indicates that marked clinical improvement may be associated with splenectomy in selected cases of agnogenic myeloid metaplasia.. ...
http://pmj.bmj.com/content/45/522/261
Giant right ventricular outflow tract thrombus in hereditary spherocytosis: a case reportGiant right ventricular outflow tract thrombus in hereditary spherocytosis: a case report
Background: In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial infections associated with splenectomy is well known. Recently, hypercoagulation disorders have also been linked to splenectomy through loss of regulation of platelet activity, loss of filtering function and post-splenectomy thrombocytosis.. Case presentation: A 28 year-old smoking women who had previously undergone splenectomy due to hereditary spherocytosis with a moderate thrombocytosis (platelet count 553-635*109/L), presented with recurrent episodes of pulmonary embolisms. Further examination by multimodality cardiac imaging demonstrated a giant chronic thrombus in the right ventricular outflow tract, which eventually had to be surgically removed.. Conclusions: The present case highlights the increased risk of severe thromboembolic complications following therapeutic ...
http://bora.uib.no/handle/1956/12159
Effective application of Ligasure in laparoscopic splenectomy for splenic abscess in an old woman - case report | BMC...Effective application of Ligasure in laparoscopic splenectomy for splenic abscess in an old woman - case report | BMC...
The laparoscopic intra-operative findings were splenic infarction, abscess in the lower part of the spleen and widespread inflammatory adhesions between spleen, greater omentum and parietal peritoneum. We performed laparoscopic splenectomy using Ligasure as device for dissection and vessels sealing. The estimated blood loss was 230 mL. The postoperative course was uneventful, no blood transfusion was needed and the patient was discharged on the 12th postoperative day. Histopathological examination confirmed infarction of the spleen and the presence of multiple abscesses. ...
https://bmcgeriatr.biomedcentral.com/articles/10.1186/1471-2318-9-S1-A51
Splenic preservation versus splenectomy in laparoscopic distal pancreatectomy: a propensity score-matched study | SpringerLinkSplenic preservation versus splenectomy in laparoscopic distal pancreatectomy: a propensity score-matched study | SpringerLink
The laparoscopic approach in distal pancreatectomy is associated with higher rates of splenic preservation compared to open surgery. Although favorable pos
https://rd.springer.com/article/10.1007%2Fs00464-019-06901-z
OpenEmory | Search ResultsOpenEmory | Search Results
Purpose: The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). Methods: The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy. Results: The analysis included 130 children, with 62.3% (n = 81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1 g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p , 0.001). For children with SCD, there was no change in hemoglobin. Laparoscopy was not associated with differences ...
https://open.library.emory.edu/publications/search/?keywords=surgeri&keywords=cell&keywords=surgic&author=Dutta,%20Sanjeev
Anterior Versus Posterolateral Approach for Total Laparoscopic Splenectomy: A Comparative Study [Abstract]Anterior Versus Posterolateral Approach for Total Laparoscopic Splenectomy: A Comparative Study [Abstract]
Abstract. Objective: Although the anterior approach is normally used for elective laparoscopic splenectomy (LS), the posterolateral approach may be superior. We have retrospectively compared the effectiveness and safety of these approaches in patients with non-severe splenomegaly scheduled for elective total LS.. Methods: Patients with surgical spleen disorders scheduled for elective LS between March 2005 and June 2011 underwent laparoscopic splenic mobilization via the posterolateral or anterior approach. Main outcome measures included operation time, intraoperative blood loss, frequency of postoperative pancreatic leakage, and length of hospital stay.. Results: During the study period, 203 patients underwent LS, 58 (28.6%) via the posterolateral and 145 (71.4%) via the anterior approach. Three patients (1.5%) required conversion to laparotomy due to extensive perisplenic adhesions. The posterolateral approach was associated with significantly shorter operation time (65.0 ± 12.3 min vs. 95.0 ...
http://www.medsci.org/v10p0222
Chapter 57. Infections in Asplenic Children | Pediatric Practice: Infectious Disease | AccessPediatrics | McGraw-Hill MedicalChapter 57. Infections in Asplenic Children | Pediatric Practice: Infectious Disease | AccessPediatrics | McGraw-Hill Medical
A child may be asplenic for anatomic or functional reasons. Anatomic reasons include: (1) congenital asplenia, which can be isolated, or part of Ivemark syndrome, which is associated with cardiovascular defects and heterotaxy and (2) splenectomy. Splenectomy may be performed for various reasons. In children, the most common reasons are trauma-associated splenic rupture, malignancy, hypersplenism, and splenomegaly associated with persistent anemia and/or thrombocytopenia.2 Functional asplenia results from having an anatomically intact but poorly working spleen. There are various conditions that can cause functional asplenia, including sickle cell disease (Table 57-1). Some of the mechanisms leading to functional asplenia include infarction, infiltration, and impaired phagocyte function.2-4 ...
http://accesspediatrics.mhmedical.com/content.aspx?bookid=453§ionid=40249732
Best of Five 139
BOF: 139. A patient who is known to have hereditary spherocytosis and has mild jaundice and gallstones is awaiting splenectomy. In this patient you would like to make sure that Pneumococcal immunisation is administered:. a) 24 hours prior to splenectomy. b) 2-3 weeks prior to splenectomy. c) 2-3 months prior to splenectomy. d) 72 hours prior to splenectomy. e) 6 weeks prior to splenectomy. ...
http://ydr.org.uk/best_of_five_139.htm
Home | Lisie HospitalHome | Lisie Hospital
BILIARY TRACT. Laparoscopic cholecystectomy. Open cholecystectomy. CBD exploration. Choledochoduodenostomy. Hepatico jejunostomy for biliary stricture. Choledochal cyst excision Extended cholecystectomy for carcinoma gallbladder. Liver resections for Cholangiocarcinoma. PANCREAS. Pancreatic necrosectomy for acute pancreatitis. Freys procedure for chronic pancreatitis. Lateral pancreaticojejunostomy for chronic pancreatitis. Cystogastrostomy. Cystojejunostomy. Whipples procedure for pancreatic cancer. Central pancreatectomy. Distal pancreatectomy. Surgery for pancreatic trauma. SPLEEN. Laparoscopic splenectomy. Open splenectomy. Surgery for splenic trauma. LIVER. Surgery for hydatid cyst. Deroofing of liver cyst. Hepatectomy for liver tumors. Debridement of liver abscess. Surgery for liver trauma. PORTAL HYPERTENSION. Proximal splenorenal shunt. Distal splenorenal shunt. Side to side splenorenal shunt. Mesocaval shunt. Devascularisation. Splenectomy. ESOPHAGUS. Emergency management of corrosive ...
http://lisiehospital.org/departments/depatdetails/gacCTPXiAQ0594aHYTUaiD2TTVLzfJagalrqS-_9FZBQ3gV9ZOwfcrsj80bxoQwRufGnvzuoxokcBTwne5j_Og==
Permanent large granular lymphocytosis in the blood of splenectomized individuals without concomitant increase of in vitro...
TY - JOUR. T1 - Permanent large granular lymphocytosis in the blood of splenectomized individuals without concomitant increase of in vitro natural killer cell cytotoxicity. AU - Kelemen, E.. AU - Gergely, P.. AU - Lehoczky, D.. AU - Triska, E.. AU - Demeter, J.. AU - Vargha, P.. PY - 1986. Y1 - 1986. N2 - Increased numbers of circulating lymphocytes and large granular lymphocytes (LGL) were observed in 115 individuals splenectomized for haematological disease (74 cases) or for trauma (41 cases). LGL lymphocytosis was present in 78.4% of haematologically indicated and in 85.4% of traumatic splenectomies. A 70.5% of these values was above the 97.5 percentile upper tolerance limit of healthy controls (200 cases). In addition, 175 haematological controls were investigated. Forty per cent or more of circulating lymphocytes exhibited LGL morphology in nearly half of repeatedly investigated splenectomized persons. The increase in LGL is not attributable to lymphocytosis. It becomes apparent, and ...
https://hungary.pure.elsevier.com/en/publications/permanent-large-granular-lymphocytosis-in-the-blood-of-splenectom
The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen | BMC Infectious Diseases | Full TextThe role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen | BMC Infectious Diseases | Full Text
Asplenic individuals are susceptible for overwhelming infection with Streptococcus pneumoniae, carrying a high mortality. Although Toll-like receptor (TLR)-2 is considered the major receptor for Gram-positive bacteria in innate immunity, it does not play a major role in host defense against pneumococcal pneumonia. We wanted to investigate if in absence of an intact spleen as a first line of defense, the role of TLR2 during pneumococcal pneumonia becomes more significant, thereby explaining its insignificant role during infections in immune competent hosts. We intranasally infected splenectomized wildtype (WT), TLR2 knock-out (KO) and TLR2/4 double KO mice with either serotype 2 or 3 S. pneumoniae. There were no differences between asplenic WT and TLR2KO mice of bacterial loads in lung homogenates and blood, cytokine and chemokine levels in the lungs, and lung pathology scores. TLR2/4 double KO mice were not impaired in bacterial control as well, which indicates that besides the interaction between S.
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-12-139
Surgeons Practicing Laparoscopic Nissen Fundoplication, Nephrectomy, Splenectomy and Colorectal surgery on the live tissue.Surgeons Practicing Laparoscopic Nissen Fundoplication, Nephrectomy, Splenectomy and Colorectal surgery on the live tissue.
Today the surgeons performed the Laparoscopic splenectomy using the lateral Approach. The anterior approach is not used much these days.  Dissection for a ...
https://www.laparoscopyhospital.com/alumni/preview.php?eid=72&p=132&search=
Hypersplenism, Information about HypersplenismHypersplenism, Information about Hypersplenism
Hypersplenism is a disorder that causes the spleen to rapidly and prematurelydestroy blood cells.. The spleen is located in the upper left area of the abdomen. One of its majorfunctions is to remove blood cells from the bodys bloodstream. In hypersplenism, the spleens normal function accelerates, and it begins to remove cellsthat may still be normal in function. Sometimes, the spleen will temporarilyhold onto up to 90% of the bodys platelets and 45% of the red blood cells.Hypersplenism may occur as a primary disease, leading to other complications,or as a secondary disease, resulting from an underlying disease or disorder.Hypersplenism is sometimes referred to as enlarged spleen (splenomegaly). Anenlarged spleen is one of the symptoms of hypersplenism. What differentiateshypersplenism is its premature destruction of blood cells.. Hypersplenism may be caused by a variety of disorders. Sometimes, it is brought on by a problem within the spleen itself and is referred to as primary hypersplenism. ...
http://www.faqs.org/health/topics/46/Hypersplenism.html
Hairy cell leukemia | Splenectomy. Surgery: Treatment in Switzerland, top hospitals from BookingHealth.comHairy cell leukemia | Splenectomy. Surgery: Treatment in Switzerland, top hospitals from BookingHealth.com
Hairy cell leukemia | Splenectomy. Surgery: Treatment in Switzerland ✈. Prices on BookingHealth.com - booking treatment online
https://bookinghealth.com/programs/treatment/surgery/hairy-cell-leukemia-splenectomy/switzerland
Advances in ITP - therapy and quality of life - a patient survey.Advances in ITP - therapy and quality of life - a patient survey.
Current guidelines recommend glucocorticoids and splenectomy as standard 1(st) and 2(nd) line treatments for chronic immune thrombocytopenia (ITP). We sought to find out how German ITP-patients are treated with respect to these guidelines. Members of a patient support association ≥18 years with a self-reported history of chronic ITP,12 months were surveyed with a web-based questionnaire. 122 questionnaires were evaluated. 70% of patients had chronic ITP for more than 5 years and 20% an average platelet count of ≤30·10(9)/L. 41% of the patients reported haematomas or petechiae more than once or twice and up to 12 times or more per year and 17% oropharyngeal and nasal bleeds. 11% had been admitted to hospital during the last 12 months. 88% had received or currently receive glucocorticoids, 27% were splenectomised. IVIG had been given to 55%, rituximab to 22%, anti-D to 12%, ciclosporin to 7%, while complementary and alternative medical treatments had been used by 36%. 50 women responded to ...
https://epub.ub.uni-muenchen.de/15586/index.html
Asian Journal of Transfusion Science (AJTS): Table of ContentsAsian Journal of Transfusion Science (AJTS): Table of Contents
Background: This study was designed to perform serial assessment of alterations in platelet (PLT) count, morphology and biochemical markers of PLT activation during storage of platelet concentrates (PCs) and to correlate morphological changes with these activation markers. Materials and Methods: Our study included the platelet-rich plasma (PRP)-PC and buffy coat reduced PC (BC-PC) prepared from whole blood (WB) donations and the apheresis platelets (AP-PC). Routinely evaluated in vitro PLT parameters were followed. Morphology score (MS) was performed using the light microscopy, glucose and lactate concentration and soluble P-selectin (sP-selectin) level were determined using commercial kits. Results: The fall in mean pH from day 0 to the last day of storage was significant (P , 0.001) in all the groups. Glucose utilization was less in PRP-PC prepared from WB donations at Blood Donation Centre [PRP-PC (BDC)] when compared to PRP-PC prepared from WB donations at mobile blood drives [PRP-PC (M)] ...
http://www.ajts.org/showBackIssue.asp?issn=0973-6247
A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model<...
TY - JOUR. T1 - A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model. AU - Yamaguchi, Y.. AU - Halperin, E. C.. AU - Harland, R. C.. AU - Wyble, C.. AU - Bollinger, R. R.. PY - 1989/12/1. Y1 - 1989/12/1. UR - http://www.scopus.com/inward/record.url?scp=0024909116&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024909116&partnerID=8YFLogxK. M3 - Article. C2 - 2662528. AN - SCOPUS:0024909116. VL - 21. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 3. ER - ...
https://arizona.pure.elsevier.com/en/publications/a-synergistic-effect-of-total-lymphoid-irradiation-cyclosporine-a
AsplenicAsplenic
This page includes the following topics and synonyms: Asplenic, Asplenia, Functional Asplenia, Asplenism, Hyposplenism, Hyposplenic, Postsplenectomy.
http://www.fpnotebook.com/GI/Spleen/Asplnc.htm
Plus itPlus it
The effect of Nembutal on the circulating and tissue blood volumes and hematocrits was calculated by means of independent determinations of plasma and red cell volumes. Nembutal produced an increase in circulating blood volume accompanied by a reduction in the venous hematocrit. The blood volumes of liver, kidney, spleen and intestine rose following the administration of Nembutal, while the hematocrits of liver, lung, intestine and muscle declined, and that of kidney rose. The administration of Nembutal to splenectomized mice produces similar changes. The relationship of these alterations to changes in periphero-vascular tone are discussed.. ...
http://ajplegacy.physiology.org/content/197/2/399
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http://yui.saikyoh.jp/cgi-bin/yybbs/yybbs.cgi?page=35&bl=0&list=thread
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
OBJECTIVE: To investigate the role and mechanism of splenic myeloid-derived suppressor cells (MDSCs) in sepsis-induced adrenal injury (SAI). METHODS: Thirty male C57 mice aged 6-8 weeks were randomly divided into normal control group (n = 5), sham operation group (Sham group, n = 5), sepsis model group [cecal ligation and perforation (CLP) group, n = 10] and sepsis+splenectomy group (CLPS group, n = 10). The sepsis model of mice was reproduced by CLP method. In Sham group, only the cecum was opened and separated, then closed, without CLP. In CLPS group, the spleen was removed before CLP. In normal control group, no challenge was given. After 24 hours, the rats were sacrificed by anesthesia, and peripheral blood, spleen, bone marrow, and bilateral adrenal glands were harvested. The pathological of adrenal gland was assessed by hematoxylin-eosin (HE) staining under optical microscope. The ratio of MDSCs in peripheral blood, spleen and bone marrow was determined by flow cytometry. The expressions ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:%22Ba%C3%A7o/citologia%22
Pleural nodules in a patient with a colonic tumour | ThoraxPleural nodules in a patient with a colonic tumour | Thorax
From the question on page 395 Clinical and CT findings suggested a differential diagnosis between pleural metastasis and splenosis. Histopathology revealed normal splenic tissue, allowing the diagnosis of pleural splenosis.. Thoracic splenosis (TS) is a benign acquired condition involving the autotransplantation of splenic tissue into the pleural cavity. It frequently results from left upper abdominal trauma with concomitant splenic damage and left diaphragmatic tear. Splenic tissue gains access to the left pleural space and derives its blood supply from the pleura, chest wall or diaphragm. TS is usually asymptomatic and found incidentally by imaging examinations performed for other reasons. It rarely causes chest pain or haemoptysis.1-5 The average interval between trauma and TS diagnosis is ∼20 years.. Splenic implants are sessile or pedunculated reddish-blue nodules of normal splenic tissue with diameters ranging from a few millimetres to several centimetres.2 They may occur on the parietal ...
http://thorax.bmj.com/content/69/4/395
Makale » DergiParkMakale » DergiPark
ejgm71760, journal = {European Journal of General Medicine}, issn = {1304-3889}, address = {Sağlık Bilimleri Araştırmaları Derneği}, year = {2015}, volume = {9}, pages = {33 - 35}, doi = {}, title = {LAPAROSCOPİC SPLENECTOMY FOR SPLENIC CYST HYDATIC; CASE REPORT}, language = {en}, key = {cite}, author = {SÖZEN, SELİM and ÖZDAŞ, SABRİ and AKDOĞAN, NEVZAT and AZİRET, MEHMET} } @ { ejgm71760, journal = {European Journal of General Medicine}, issn = {1304-3889}, address = {Sağlık Bilimleri Araştırmaları Derneği}, year = {2015}, volume = {9}, pages = {33 - 35}, doi = {}, title = {LAPAROSCOPİC SPLENECTOMY FOR SPLENIC CYST HYDATIC; CASE REPORT}, language = {tr}, key = {cite}, author = {SÖZEN, SELİM and ÖZDAŞ, SABRİ and AKDOĞAN, NEVZAT and AZİRET, MEHMET ...
http://dergipark.gov.tr/ejgm/issue/5297/71760
Omental Infarct at Site of Distal Pancreatectomy and Splenectomy - Pancreas Case Studies - CTisus CT ScanningOmental Infarct at Site of Distal Pancreatectomy and Splenectomy - Pancreas Case Studies - CTisus CT Scanning
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
http://ctisus.com/responsive/teachingfiles/pancreas/391240
Surgeonsblog: Two Spleen...Surgeonsblog: Two Spleen...
In doing elective open splenectomy, I liked to wear a headlight. It gets dark up there behind the ribs. Delivering the spleen into the midline, light isnt a problem. Its in the cleaning up after: that empty space where the spleen used to be is high up and back there a ways. Getting it up and out involves dividing the filmy but firm attachments between the lateral surfaces of the spleen and the peritoneal gutter in which it lies. In a dry field, it may be done sharply: long-handled scissors, or extended-length cautery with a nice bend in the tip. When the area is full of blood, you tend to do it dickless (in the sense of not dicking around. And what the heck, this is already an NC-17 blog, right?) Reach in -- in large people, it can be up to the elbow -- paddle the spleen with your fingers, like playing a sticky piano, to sense how bad it is; diggle your fingertips into the peritoneal attachments until it breaks free. Once the spleen is out, one of my favorite -- if simple -- maneuvers is the ...
http://surgeonsblog.blogspot.com/2007/06/two-spleen.html
Should medical treatment options be exhausted before splenectomy is performed in adult ITP patients? A debate | SpringerLinkShould medical treatment options be exhausted before splenectomy is performed in adult ITP patients? A debate | SpringerLink
Patients with primary immune thrombocytopenia (ITP) may require treatment to reduce the risk of serious bleeding if platelets remain consistently below 30 × 109/L. While approximately 70-80% of patien
https://link.springer.com/article/10.1007%2Fs00277-010-1066-2
Abdominal Multiple Splenosis Mimicking Liver and Colon Tumors: A Case Report and Review of the LiteratureAbdominal Multiple Splenosis Mimicking Liver and Colon Tumors: A Case Report and Review of the Literature
As we all know, for malignant tumors, contrast CT imaging often shows quick-in and quick-out property. The abdominal masses of this patient were diagnosed as malignant tumors by contrast CT imaging because at artery phase the density of mass margin increased quickly while at venous phase the density decreased quickly, which shows the characteristic of malignant tumors. Therefore, we performed the operation. Unfortunately, finally we recognized that we misdiagnosed the disease which was actually ectopic spleen tissues.. As a matter of fact, we did not realize this disease prior to operation because we never heard of it. As a result, we performed the operation, and we figured out actually the tumors of liver and colon were spleen tissues. Then we reviewed some literatures, and acquired that this condition is splenosis, which often occurs in patients who ever underwent splenectomy7,8.. Intraabdominal splenosis is a generally asymptomatic entity incidentally diagnosed after the completion of CT scan ...
http://www.medsci.org/v09p0174.htm
Rene G. Garcia Attorney: March 2013Rene G. Garcia Attorney: March 2013
Laparoscopic splenectomy is done using an instrument called a laparoscope. This is a slender tool with a light and camera on the end. The surgeon makes three or four small cuts in your abdomen, and inserts the laparoscope through one of them. This allows the doctor to look into the abdominal area and locate your spleen. Different medical instruments are passed through the other openings. One of them is used to deliver carbon dioxide gas into your abdominal area, which pushes nearby organs out of the way and gives your surgeon more room to work. The surgeon disconnects the spleen from surrounding structures and the bodys blood supply, and then removes it through the largest surgical opening. The surgical openings are closed using stitches or sutures ...
https://renegarciaattorney.blogspot.com/2013/03/
A postal survey was sent to major providers of tertiary sys - need pass top
It could be speculated that different pathological mechanisms underlie widespread significant brain perfusion decrements in temporal, parietal and frontal regions. Otherwise, a standard radical surgery is still tadalafil price the treatment of choice. To determine the prevalence and characters of tadalafil generic anomalous coronary artery, including the associations of myocardial ischemia. Because of 75 years of apartheid, the new government is faced with a formidable array of problems, both in health care and in the economic domain.. Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype. Preparation, characterization and biological evaluation of cationic 99Tc/99mTc-dioxime complexes. Evaluation of an automatic measuring device for determining certain constituents tadalafil 20mg lowest price of the urinary status The real value lies in use of data for program planning, resource allocation, program design, and evaluation. This is the first ...
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How can I rebuild my abdominal muscles after a splenectomy? - Answered by top doctors on HealthTapHow can I rebuild my abdominal muscles after a splenectomy? - Answered by top doctors on HealthTap
Dr. Hoepfner responded: Exercise. Usually after you have healed, gradual return to full activities and exercises will usually improve your abdominal muscles. Walking, |a href=/topics/bicycling track_data={
https://www.healthtap.com/user_questions/25260-how-can-i-rebuild-my-abdominal-muscles-after-a-splenectomy
Belajar pola candlestick reversal lvl trading binary forex paling akurat dan lengkap - opsi biner Malaysia 2020 terpercaya
Belajar pola candlestick reversal lvl trading binary forex paling akurat dan lengkap. Olymp Trade tutorial deutsch, opsi biner Malaysia 2020 terpercaya
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Dr. Moms Office: 2011Dr. Moms Office: 2011
3) Under the best circumstances, if no further treatment is possible Mr. Jobs will suffer from progressive liver failure slip off into a painless coma and not wake up. That was the condition he was approaching when the first transplantation was done. Depending on the amount of liver function that he has left this time can be estimated from weeks to months although without some new treatment, and based solely on statistical data, I would be surprised but not amazed to find that he made it to the end of the year. It all really depends on how rapid the tumors in his liver, & elsewhere grow and impair his functioning. What I have been waiting for, fearfully, was that he would suffer a catastrophic complication of his treatment, i.e. rapid liver failure due to ischemia of the liver, overwhelming infection as a result of the immunosuppression needed to prevent rejection of his transplanted liver and would die unexpectedly in a spectacular fashion (Sorry if that sounds callous but thats what we ...
http://mydrmom.blogspot.com/2011/
Dr. Moms Office: 8/21/11 - 8/28/11Dr. Moms Office: 8/21/11 - 8/28/11
3) Under the best circumstances, if no further treatment is possible Mr. Jobs will suffer from progressive liver failure slip off into a painless coma and not wake up. That was the condition he was approaching when the first transplantation was done. Depending on the amount of liver function that he has left this time can be estimated from weeks to months although without some new treatment, and based solely on statistical data, I would be surprised but not amazed to find that he made it to the end of the year. It all really depends on how rapid the tumors in his liver, & elsewhere grow and impair his functioning. What I have been waiting for, fearfully, was that he would suffer a catastrophic complication of his treatment, i.e. rapid liver failure due to ischemia of the liver, overwhelming infection as a result of the immunosuppression needed to prevent rejection of his transplanted liver and would die unexpectedly in a spectacular fashion (Sorry if that sounds callous but thats what we ...
http://mydrmom.blogspot.com/2011_08_21_archive.html
Causes of multiple organ failure - Doctor answersCauses of multiple organ failure - Doctor answers
Causes of multiple organ failure - Help docs! Im trying to find out what causes multiple organ failure? Low blood supply. Low blood supply to the body will cause all organs to malfunction and fail if not corrected. Low blood supply can be caused by heart failure, low blood volume (bleeding, dehydration) and overwhelming infection, among others.
https://www.healthtap.com/topics/causes-of-multiple-organ-failure
Pattericos Pontifications » Return of the mythical death panels? (Bumped and Updated)
If a youngish person is in good health, an urgent life-threatening situation is likely to be trauma or overwhelming infection, like meningitis. In either case, virtually everybody would do whatever they could. Otherwise healthy people can recover from devastating trauma, etc., and you will not know how it turns out until it does.. If a 20 year old gets leukemia they will be treated to the max initially because many leukemias have impressive cure rates. Now, if that person is now 23 and has relapsed multiple times and has failed 2 bone marrow transplants, the desire/will/ability to keep going will be an issue to discuss.. The problem with checklists is that they are…checklists, a list of things to go through by rote, not because you expect anything of usefulness. Now, I know fighter pilots have their checklists, and I imagine the consequences of missing something are great motivations to stay alert, but often a checklist means you can do it with your mind not really paying attention (mine ...
http://patterico.com/2010/12/27/return-of-the-mythical-death-panels/
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites | ScienceIdentification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites | Science
We next compared the relative contributions of the spleen and the bone marrow in response to MI by using mice in which only one of the two tissues can contribute monocytes. First, we evaluated Ccr2-/- mice, because the chemokine receptor mediates monocyte mobilization from the bone marrow (9, 21), but not from the spleen (table S4). The number of blood monocytes comparably increased-and the number of splenic monocytes comparably decreased-after MI in both wild-type and Ccr2-/- mice (Fig. 3E). The released monocytes in Ccr2-/- mice did not accumulate in the ischemic myocardium, because infiltration depends on the chemokine CCR2 [table S4 and (7)]. Second, we evaluated animals splenectomized by a procedure that preserves the bone marrow and blood monocyte pools (fig. S7). After MI, blood monocyte numbers increased in control, but not splenectomized, animals (Fig. 3F). Analysis of the ischemic myocardium revealed a massive influx of Ly-6Chigh monocytes in mice containing the spleen. However, this ...
https://science.sciencemag.org/content/325/5940/612?ijkey=64a9dd9a3631573697b00871ec4544fb8de6fd82&keytype2=tf_ipsecsha
Spleen Disorders - Information on Spleen Problems
Spleen disorders are mainly a danger when left unaddressed. Although you can survive having you spleen removed (called a splenectomy), you might not be able to survive the causes of spleen disorders. That is why it is important to make an appointment with your doctor if you feel you may have a spleen condition. The purpose and function of the spleen. The spleen is a bodily organ that rests in the left side of the abdominal cavity, between the 9th to 12th ribs. The spleens central purpose is to get rid of old red blood cells, although it also functions as reservoir for blood in case you suddenly need it due to some sort of trauma.
http://www.spleendisorders.net
Symptoms causes treatment of disease: SpleenSymptoms causes treatment of disease: Spleen
Early detection of problems which concern the spleen is highly critical because when these are just being left untreated, these may probably lead to life-threatening situations. The treatment for pain relating to the spleen would vary immensely depending on the underlying pathology. Before your physician would prescribe you a specific treatment, your exact condition must first be determined. For instance, when the splenic pain is primarily felt due to an underlying infection may entirely be treated with antibiotics. When for instance this is caused by the presence of tumor near the spleen, surgery, chemotherapy and other common ways of treating cancer may help palliate or perhaps treat the condition. However, when it is all due to a ruptured spleen, a splenectomy, which is the surgical removal of the spleen, may be indicated. This surgical procedure poses several risks though. Since the spleen has been already removed, the person this time becomes more susceptible to infections. Thus, vaccines ...
http://symptoms-causes-treatment.blogspot.com/2013/10/spleen.html
SplenectomySplenectomy
... may also lead to chronic neutrophilia. Splenectomy patients typically have Howell-Jolly bodies and less commonly ... An increase in blood leukocytes can occur following a splenectomy. The post-splenectomy platelet count may rise to abnormally ... A splenectomy also results in a greatly diminished frequency of memory B cells. A 28-year follow-up of 740 World War II ... A splenectomy is the surgical procedure that partially or completely removes the spleen. The spleen is an important organ in ...
https://en.wikipedia.org/wiki/Splenectomy
Overwhelming post-splenectomy infectionOverwhelming post-splenectomy infection
An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following ... Most infections occur in the first few years following splenectomy, but the risk of OPSI is lifelong. The risk is greatest for ... The spleen is necessary for protection against encapsulated bacteria (see Mechanism) and as such when removed by splenectomy it ... Greater risk is associated with splenectomy for hematological conditions such as sickle cell anemia, thalassemia and tumours ...
https://en.wikipedia.org/wiki/Overwhelming_post-splenectomy_infection
Francis de Havilland HallFrancis de Havilland Hall
Hall, F. D.; Spencer, W. G. (1909). "Splenectomy for (?) Splenic Anæmia". Proceedings of the Royal Society of Medicine. 2 (Clin ...
https://en.wikipedia.org/wiki/Francis_de_Havilland_Hall
AspleniaAsplenia
New York, NY: McGraw-Hill Education "Splenectomy and Infection" (PDF). Splenectomy Trust. March 2002. Archived from the ... Following splenectomy due to splenic rupture from trauma or because of tumor After splenectomy with the goal of interfering ... "Splenectomy wallet card". HSC Public Health Agency. Belfast. Archived from the original on 2 August 2019. Retrieved 1 August ... This can lead to results similar to those seen in patients who have undergone a splenectomy e.g. becoming infected with ...
https://en.wikipedia.org/wiki/Asplenia
LymphocytosisLymphocytosis
Juneja, S; Januszewicz, E; Wolf, M; Cooper, I (1995). "Post-splenectomy lymphocytosis". Clinical and Laboratory Haematology. 17 ... such as tuberculosis or brucellosis chronic lymphocytic leukemia acute lymphoblastic leukemia lymphoma post-splenectomy state ...
https://en.wikipedia.org/wiki/Lymphocytosis
Portal vein thrombosisPortal vein thrombosis
Cadili A, de Gara C (May 2008). "Complications of splenectomy". The American Journal of Medicine. 121 (5): 371-5. doi:10.1016/j ...
https://en.wikipedia.org/wiki/Portal_vein_thrombosis
Jan KubišJan Kubiš
A splenectomy was performed. The chest wound, left lung, and diaphragm were all debrided and the wounds closed. Himmler ordered ...
https://en.wikipedia.org/wiki/Jan_Kubiš
Sugiura procedureSugiura procedure
A splenectomy is initially performed and is followed by devascularization of the distal esophagus through the diaphragm hiatus ... Splenectomy is then performed. The abdominal esophagus is devascularized from the stomach. The posterior gastric vagus nerve ... The abdominal operation consists of a splenectomy, devascularization of the abdominal esophagus and cardia, and a selective ... The procedure also involves a splenectomy. The operation was originally developed to treat bleeding esophageal varices ( ...
https://en.wikipedia.org/wiki/Sugiura_procedure
Beta thalassemiaBeta thalassemia
Patients with thalassemia major are more inclined to have a splenectomy. The use of splenectomies have been declining in recent ... Splenectomy is also associated with increased risk of infections and increased morbidity due to vascular disease, as the spleen ... If it is unnecessary to remove the entire spleen a partial splenectomy may occur; this method preserves some of the immune ... Those undergoing splenectomy should receive an appropriate pneumococcal vaccine at least one week (preferably three weeks) ...
https://en.wikipedia.org/wiki/Beta_thalassemia
AutosplenectomyAutosplenectomy
"Splenectomy Results - Mayo Clinic". www.mayoclinic.org. Retrieved 2016-03-03. "What Is the Spleen? Functions & Info , ... "Splenectomy Risks - Mayo Clinic". www.mayoclinic.org. Retrieved 2016-03-02. Brigden, Malcolm L. (February 2001). "Detection, ... Lack of a spleen, called asplenia, can occur by autosplenectomy or the surgical counterpart, splenectomy. Asplenia can increase ... Di Sabatino, Antonio (April 6, 2011). "Post-splenectomy and hyposplenic states". Lancet. 378 (9785): 86-97. doi:10.1016/s0140- ...
https://en.wikipedia.org/wiki/Autosplenectomy
SpleenSpleen
A splenectomy (removal of the spleen) results in a greatly diminished frequency of memory B cells. A 28-year follow-up of 740 ... 1977). "Splenectomy and Subsequent Mortality in Veterans of the 1939-45 War". The Lancet. 310 (8029): 127-29. doi:10.1016/S0140 ... Splenosis is a condition where displaced pieces of splenic tissue (often following trauma or splenectomy) autotransplant in the ... Di Sabatino, A; Carsetti, R; Corazza, GR (Jul 2, 2011). "Post-splenectomy and hyposplenic states". Lancet. 378 (9785): 86-97. ...
https://en.wikipedia.org/wiki/Spleen
Blunt splenic traumaBlunt splenic trauma
Treatment has traditionally been splenectomy. Splenectomy involves ligation of three splenic attachments (splenorenal ligament ... However, splenectomy is avoided if possible, particularly in children, to avoid the resulting permanent susceptibility to ... When surgery is needed, the spleen can be surgically repaired in a few cases, but splenectomy is still the primary surgical ... 2], Suah A, Williams B. Exploratory Laparotomy and Splenectomy for Ruptured Spleen Following Blunt Force Trauma. J Med Ins. ...
https://en.wikipedia.org/wiki/Blunt_splenic_trauma
Hereditary pyropoikilocytosisHereditary pyropoikilocytosis
Splenectomy is curative when this occurs. HPP has been associated with a defect of the erythrocyte membrane protein spectrin ... Splenectomy is a possible treatment[citation needed] Erythrocyte Poikilocytosis List of hematologic conditions " ...
https://en.wikipedia.org/wiki/Hereditary_pyropoikilocytosis
Feltys syndromeFelty's syndrome
Splenectomy may improve neutropenia in severe disease. Use of rituximab and leflunomide have been proposed. Use of gold therapy ... Hanrahan, Edward M., Jr.; Miller, Sydney R. (8 October 1932). "Effect of splenectomy on Felty's syndrome". Journal of the ...
https://en.wikipedia.org/wiki/Felty's_syndrome
Warm antibody autoimmune hemolytic anemiaWarm antibody autoimmune hemolytic anemia
If ineffective, splenectomy should be considered.[citation needed] If refractory to both these therapies, other options include ...
https://en.wikipedia.org/wiki/Warm_antibody_autoimmune_hemolytic_anemia
Phrenicocolic ligamentPhrenicocolic ligament
Poulin EC, Thibault C (October 1993). "The anatomical basis for laparoscopic splenectomy". Can J Surg. 36 (5): 484-8. PMID ... and the variations of suspensory ligament of the spleen it is essential in the case of open surgery or laparoscopic splenectomy ...
https://en.wikipedia.org/wiki/Phrenicocolic_ligament
Hereditary stomatocytosisHereditary stomatocytosis
Unlike hereditary spherocytosis, splenectomy is contraindicated. Andolfo I, Russo R, Gambale A, Iolascon A (January 2018). " ...
https://en.wikipedia.org/wiki/Hereditary_stomatocytosis
Southeast Asian ovalocytosisSoutheast Asian ovalocytosis
Patients with severe haemolytic anemia may require splenectomy.[citation needed] Hereditary elliptocytosis Sickle-cell disease ...
https://en.wikipedia.org/wiki/Southeast_Asian_ovalocytosis
White blood cellWhite blood cell
McBride JA, Dacie JV, Shapley R (February 1968). "The effect of splenectomy on the leucocyte count". British Journal of ...
https://en.wikipedia.org/wiki/White_blood_cell
Shane ParrishShane Parrish
He undergoes a splenectomy and makes a recovery. To celebrate Shane and Angel's first anniversary, the couple and Dylan take a ...
https://en.wikipedia.org/wiki/Shane_Parrish
Subphrenic abscessSubphrenic abscess
This abscess develops after surgical operations like splenectomy. Presents with cough, increased respiratory rate with shallow ...
https://en.wikipedia.org/wiki/Subphrenic_abscess
List of -ectomiesList of -ectomies
Splenectomy is the surgical removal of the spleen. Autosplenectomy is where certain diseases destroy the spleen's function. ...
https://en.wikipedia.org/wiki/List_of_-ectomies
Autoimmune hemolytic anemiaAutoimmune hemolytic anemia
In this case, splenectomy may be considered, as well as other immunosuppressive drugs. Infection is a serious concern in ... Splenectomy is less efficacious in cold agglutinin disease. Special considerations are required when treating people with AIHA ... splenectomy can be done. Other third line options, that are less studied, include azathioprine, cyclophosphamide, cyclosporine ...
https://en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia
BENTA diseaseBENTA disease
Splenectomy is unlikely to reduce B cell burden; peripheral blood B cell counts rose significantly in three patients who ...
https://en.wikipedia.org/wiki/BENTA_disease
Splenic infarctionSplenic infarction
Splenectomy may be warranted for persistent pseudocysts due to the high risk of subsequent rupture. Although it can occur ... It can also be used prior to splenectomy for the prevention of blood loss. Chapman, J; Bhimji, SS (2018), "article-29380", ... Surgical removal of the spleen (splenectomy) is only required if complications ensue; surgical removal predisposes to ... only seldom requires splenectomy. Case report and literature review". Ann Ital Chir. 78 (6): 529-32. PMID 18510036. Suzuki Y, ...
https://en.wikipedia.org/wiki/Splenic_infarction
Trauma (American TV series)Trauma (American TV series)
Nancy suffers internal bleeding and requires a splenectomy. The Chief of Staff at the hospital (who just happens to be Nancy's ...
https://en.wikipedia.org/wiki/Trauma_(American_TV_series)
Management of thalassemiaManagement of thalassemia
Removal of the spleen (splenectomy) could theoretically help to reduce the need for blood transfusions in people with ... Sharma, A; Easow Mathew, M; Puri, L (17 September 2019). "Splenectomy for people with thalassaemia major or intermedia". The ...
https://en.wikipedia.org/wiki/Management_of_thalassemia
NeutrophiliaNeutrophilia
... can also be caused by appendicitis and splenectomy. Primary neutrophilia can additionally be a result of leukocyte ...
https://en.wikipedia.org/wiki/Neutrophilia
Hairy cell leukemiaHairy cell leukemia
Splenectomy can produce long-term remissions in patients whose spleens seem to be heavily involved, but its success rate is ... Splenectomies are also performed for patients whose persistently enlarged spleens cause significant discomfort or in patients ... More than half of people respond partially to splenectomy. In terms of B-cell development, the prolymphocytes are less ...
https://en.wikipedia.org/wiki/Hairy_cell_leukemia
Jessie MarmorstonJessie Marmorston
"Effect of Splenectomy on a Latent Infection, Eperythrozoon Coccoides, in White Mice" (1935) "The Effect of Splenectomy on ... Marmorston, Jessie (1935). "Effect of Splenectomy on a Latent Infection, Eperythrozoon Coccoides, in White Mice". The Journal ... Marmorston, Jessie (1937-07-01). "The Effect of Splenectomy on Tuberculous Infection in Mice". American Review of Tuberculosis ...
https://en.wikipedia.org/wiki/Jessie_Marmorston
Splenomegaly Workup: Approach Considerations, Findings in Hypersplenism, Splenectomy and Splenic BiopsySplenomegaly Workup: Approach Considerations, Findings in Hypersplenism, Splenectomy and Splenic Biopsy
Splenectomy. Splenectomy may be considered in certain individuals to determine the etiology of splenomegaly, though early ... Hand-assisted laparoscopic splenectomy for splenomegaly: a comparative study with conventional laparoscopic splenectomy. Chin ... Splenectomy in hematologic disorders. The ever-changing indications. Ann Surg. 1988 May. 207(5):581-9. [QxMD MEDLINE Link]. [ ... Laparoscopic splenectomy in patients with hematologic diseases. Ann Surg. 1996 Jul. 224(1):19-28. [QxMD MEDLINE Link]. [Full ...
https://emedicine.medscape.com/article/206208-workup
Post-splenectomy complications: MedlinePlus Medical EncyclopediaPost-splenectomy complications: MedlinePlus Medical Encyclopedia
Post-splenectomy complications can occur after surgery to remove the spleen. Complications may include: ... Splenectomy - post-surgery syndrome; Overwhelming post-splenectomy infection; OPSI; Splenectomy - reactive thrombocytosis ...
https://medlineplus.gov/ency/article/001290.htm
Evans Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, SplenectomyEvans Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Splenectomy
Splenectomy. Splenectomy does not have a clearly established role in the treatment of Evans syndrome, but it may be considered ... Splenectomy may improve the CBC and reduce steroid dependence; however, relapses are common and, in most cases, occur within 1- ... Prior to splenectomy, all patients should be immunized against S pneumoniae, Haemophilus influenzae type b, and Neisseria ... 28] A retrospective study by Sulpizio et al indicated that the 1-year remission rate following splenectomy is greater in ...
https://www.medscape.com/answers/955266-181207/which-specialist-consultations-are-beneficial-to-patients-with-evans-syndrome
Hereditary Spherocytosis Treatment & Management: Approach Considerations, Splenectomy, ConsultationsHereditary Spherocytosis Treatment & Management: Approach Considerations, Splenectomy, Consultations
Splenectomy is the definitive treatment for HS. [4] Except in the unusual autosomal recessive variant of HS, splenectomy ... Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. ... Splenectomy. Generally, the treatment of HS involves presplenectomy care, splenectomy, and management of postsplenectomy ... This is especially true for those who have not undergone splenectomy. After splenectomy, all patients should have immunizations ...
https://emedicine.medscape.com/article/206107-treatment
Laparoscopic Splenectomy (Discharge Care)Laparoscopic Splenectomy (Discharge Care)
Care guide for Laparoscopic Splenectomy (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment ... Laparoscopic Splenectomy. Medically reviewed by Drugs.com. Last updated on Dec 2, 2022. ... Laparoscopic splenectomy is surgery to take out all or part of your spleen. ...
https://www.drugs.com/cg/laparoscopic-splenectomy-discharge-care.html
JCI - Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of ErythrocytesJCI - Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes
Splenectomy led to an increased survival of IgG-coated cells and a sixfold increase in IgG C1-fixing sites was necessary in ... Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes. John P. Atkinson, Alan D. ... Corticosteroids and splenectomy constitute two important therapeutic modalities in the treatment of autoimmune hemolytic anemia ... These experiments clearly demonstrate that both corticosteroid therapy and splenectomy act to decrease the in vivo clearance of ...
https://www.jci.org/articles/view/107325
Laparoscopic splenectomy in the armamentarium of the colorectal surgeon - a video vignetteLaparoscopic splenectomy in the armamentarium of the colorectal surgeon - a video vignette
... Colorectal Dis. 2019 Nov;21(11):1342 ...
https://pubmed.ncbi.nlm.nih.gov/31373154/
Splenectomy | Temple HealthSplenectomy | Temple Health
Splenectomy is the surgical removal of your spleen - a blood-filtering organ in your abdomen. Learn more from Temple Health ... Splenectomy. A splenectomy is the surgical removal of your spleen - a blood-filtering abdominal organ. Your spleen stores red ... Infection (rare) - If your spleen is infected, doctors may advise splenectomy.. Splenectomy can remove diseased organs and ... Splenectomy can treat immune disorders, organ abnormalities, cancer and conditions such as:. *Immune thrombocytopenia purpura ( ...
https://www.templehealth.org/services/treatments/splenectomy
Laparoscopic Splenectomy With Balloon Occlusion of the Splenic Artery from the SAGES Video LibraryLaparoscopic Splenectomy With Balloon Occlusion of the Splenic Artery from the SAGES Video Library
Laparoscopic Splenectomy With Balloon Occlusion of the Splenic ...
https://www.sages.org/video/laparoscopic-splenectomy-with-balloon-occlusion-of-the-splenic-artery/
Defective activation of neutrophils after splenectomy. | Journal of Clinical PathologyDefective activation of neutrophils after splenectomy. | Journal of Clinical Pathology
The mean distance migrated by normal neutrophils in the presence of serum from the patients after splenectomy was significantly ... Neutrophil chemotaxis and phagocytosis in the presence of serum from 20 patients who had undergone splenectomy and from 15 ... of neutrophils phagocytosing a yeast was also significantly reduced in the presence of serum from patients after splenectomy (p ...
https://jcp.bmj.com/content/38/10/1175
Elective Splenectomy for Hematologic Diseases, JAMA Surgery | 10.1001/jamasurg.2014.310 | DeepDyveElective Splenectomy for Hematologic Diseases, JAMA Surgery | 10.1001/jamasurg.2014.310 | DeepDyve
higher rate of complications in patients with malignant dis- Laparoscopic splenectomy is associated with better out- ease, but ... splenectomy was associated with better outcomes Surgical Quality Improvement Program database to evaluate than open splenectomy ... PhD Splenectomy remains a common procedure for the manage- Bagrodia et al. Bagrodia and colleagues found a significantly ment ... irrespective of the indication for clinical and pathologic vari- splenectomy. ables associated with 30-day Bagrodia and ...
https://www.deepdyve.com/lp/american-medical-association/elective-splenectomy-for-hematologic-diseases-eoHAzzF1cH
Platelet Disorder Support Association - for People with ITP - OK to use Mirena after a splenectomy? - PDSA Discussion GroupPlatelet Disorder Support Association - for People with ITP - OK to use Mirena after a splenectomy? - PDSA Discussion Group
My ITP has been under control since my splenectomy in August of 2009 and Ive been taking birth control pills since 2008. Im ... Also, anyone with ITP should use BC with caution because there is an added clotting risk which goes up after splenectomy.. Id ... My ITP has been under control since my splenectomy in August of 2009 and Ive been taking birth control pills since 2008. Im ... Re: OK to use Mirena after a splenectomy? 11 years 6 months ago #15220 ...
https://pdsa.org/discussion-group/9-secret-womens-business-o/15190-ok-to-use-mirena-after-a-splenectomy.html
Splenectomy | Anaheim Surgical AssociatesSplenectomy | Anaheim Surgical Associates
When only part of the spleen is removed, the procedure is called a "partial splenectomy." Without intervention, certain ... A splenectomy is the surgical removal of the spleen, an organ that helps to regulate the composition of the blood, and plays an ... diseases can cause the spleen to shrivel up and stop functioning; this is referred to as "auto-splenectomy." ... Splenectomy. A splenectomy is the surgical removal of the spleen, an organ that helps to regulate the composition of the blood ...
https://www.anaheimsurgical.com/splenectomy.php
Pharmaceutical Distribution Errors Result internal Bleeding and Avoidable Splenectomy - Pittsburgh Medical Malpractice...Pharmaceutical Distribution Errors Result internal Bleeding and Avoidable Splenectomy - Pittsburgh Medical Malpractice...
Pharmaceutical Distribution Errors Result internal Bleeding and Avoidable Splenectomy. April 28, 2016 ... As a result, she was forced to undergo an unnecessary splenectomy. Rosen Louik & Perry were contacted by the client. We were ...
https://www.caringlawyers.com/verdicts-settlements/pharmaceutical-distribution-errors-result-in-internal-bleeding-and-avoidable-splenectomy/
Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: a case report and literature...Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: a case report and literature...
More than 18 months after the splenectomy, the patient has had no evidence of recurrent gastric cancer. When solitary ... We diagnosed splenic metastasis of gastric cancer, and performed a splenectomy. Histological examination confirmed moderately ... metastasis to the spleen is suspected during the postoperative follow-up of a patient with gastric cancer, a splenectomy is a ... An OPSI can result in sepsis and meningitis after splenectomy, and 3.2% of patients who have undergone a splenectomy acquire an ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3434-y
Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use...
This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and ... This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and ... This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and ... This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and ...
https://moh-it.pure.elsevier.com/en/publications/management-of-non-neuronopathic-gaucher-disease-with-special-refe
Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related...
Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time ... Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time ... Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time ... Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time ...
https://kyushu-u.pure.elsevier.com/en/publications/hepatic-vein-waveform-and-splenomegaly-predict-improvement-of-pro
β-Thalassemia | Genetics in Medicineβ-Thalassemia | Genetics in Medicine
Splenectomy. Splenectomy should be taken into consideration in only a certain few circumstances because of the observation of ... Splenectomy and thrombosis: the case of thalassemia intermedia. J Thromb Haemost 2010;8:2152-2158. ... Because patients with TI are at high risk for thrombosis, exacerbated by splenectomy, it is important to be aware of thrombotic ... The main indications for splenectomy in TM are an increased blood requirement (annual blood requirement ,200-220 ml/kg/year) ...
https://www.nature.com/articles/gim2016173?error=cookies_not_supported&code=562a06f9-5f16-4e80-9466-584939d4d29d
Splenectomy | FewnSplenectomy | Fewn
Splenectomy by Fewn, released 01 March 2009
https://fewn.awkwardcore.com/track/splenectomy?action=download
Splenectomy - TheGIConnectionSplenectomy - TheGIConnection
First in Human Study With NG-641, a Tumour Selective Transgene Expressing Adenoviral Vector - Full Text View - ClinicalTrials...First in Human Study With NG-641, a Tumour Selective Transgene Expressing Adenoviral Vector - Full Text View - ClinicalTrials...
Splenectomy. *Active infection within 1 week of the anticipated first dose of study drug that required antibiotics (or other ...
https://www.clinicaltrials.gov/ct2/show/NCT04053283
IMSEAR at SEARO: Effect of splenectomy on lymphopoiesis.
Effect of splenectomy on lymphopoiesis. Indian Journal of Medical Sciences. 1958 Oct; 12(10): 805-7. ...
https://imsear.searo.who.int/handle/123456789/67031
Laparoscopic splenectomy - LAPAROSKOPiKLaparoscopic splenectomy - LAPAROSKOPiK
Laparoscopic splenectomy. Surgical operation video by Metin ERTEM, MD. FACS , LAPAROSKOPiK ...
http://www.laparoskopik.com/laparoskopik-egitim-videolari/dalak-kategorisi/laparoscopic-splenectomy/
Splenectomy | Orange County SurgeonsSplenectomy | Orange County Surgeons
Surgical Procedures of Splenectomy on orangecountysurgeons.org A splenectomy is the surgical removal of the spleen in the upper ... What is a Splenectomy?. A splenectomy is the surgical removal of the spleen in the upper left area of the abdomen. This ... Anesthesia with a Splenectomy:. A splenectomy is performed under general anesthesia, which means that the patient is asleep and ... Conditions Treated with a Splenectomy:. A splenectomy is utilized to remove a spleen that is diseased or damaged. It is used in ...
https://orangecountysurgeons.org/surgical-procedure/splenectomy-659
Splenectomy Archives - Medivisuals Inc. | Medivisuals Inc.Splenectomy Archives - Medivisuals Inc. | Medivisuals Inc.
Get the latest updates on MediVisuals products, services, and recent case studies delivered straight to your inbox ...
https://medivisuals.com/product-tag/splenectomy/
Meetings - The ASCO PostMeetings - The ASCO Post
Keith McCrae, MD, on Splenectomy in Immune Thrombocytopenia Keith McCrae, MD, of the Cleveland Clinic, offers his thoughts on ... abstract 232, "Long-Term Complications After Splenectomy in Adult Chronic Immune Thrombocytopenia With a Minimum Follow-up of ...
https://ascopost.com/Meetings/?m=2014+ASH+Annual+Meeting
Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19-Associated Hospitalization Among Immunocompetent...Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19-Associated Hospitalization Among Immunocompetent...
... splenectomy; or another condition that causes moderate or severe immunosuppression. ...
https://www.cdc.gov/mmwr/volumes/71/wr/mm715152e2.htm
Spleen Removal or Splenectomy in Orange County, CaliforniaSpleen Removal or Splenectomy in Orange County, California
A splenectomy is a surgery to remove the entire or partial spleen, a delicate, fist-sized organ that sits under the left rib ... Overwhelming infection that occurs after splenectomy is called OPSI or Overwhelming Post-Splenectomy Infection. OPSI is a ... Da Vinci Splenectomy is performed using the da Vinci Surgical System. It is a state-of-the-art surgical platform that provides ... WHAT ARE THE ADVANTAGES OF LAPAROSCOPIC SPLENECTOMY?. Results may vary depending on your overall condition and health. Usual ...
https://ocroboticsurgery.com/procedures/spleen-removal/
The Lancet, 20 July 1996, Volume 348, Issue 9021, Pages 139-206The Lancet, 20 July 1996, Volume 348, Issue 9021, Pages 139-206
Lymphadenectomy and pancreatico-splenectomy in gastric cancer surgery. *Takeshi Sano,. *Iain G Martin ...
https://www.thelancet.com/journals/lancet/issue/vol348no9021/PIIS0140-6736
Partial splenectomyLaparoscopic SplenectomySurgerySplenicRecovery from a splenectomyUndergoneInfectionYear after splenectomyGeneral anesthesiaComplicationsSplenomegalyRequire splenectomyUndergo splenectomyElective SplenectomyHematopoietic stem cell transIndicationsHemolyticSepsisMinimally invasiveProcedureGastrectomyCorticosteroidOrgansTherapiesBook an appointmentSignificantlyOrganPrognosisPatientsBacteriaThalassemiaTreatmentAbstractPatientRemovalRemoveIncludeIdiopathicAutoimmuneRuptureHospitalCancersErythrocytesSymptomsSurvivalInfections
Partial splenectomy6
  • An interesting alternative approach in pediatric patients has been the use of partial splenectomy to retain splenic immunologic function while at the same time reducing the rate of hemolysis. (medscape.com)
  • In children with HS who underwent total or partial splenectomy, a review found that the hemoglobin concentration increased from 10.1 ± 1.8 g/dL at baseline to 12.8 ± 1.6 g/dL at 52 weeks postoperatively. (medscape.com)
  • When part of the spleen is removed the procedure is called a partial splenectomy. (anaheimsurgical.com)
  • A partial splenectomy is performed when only a portion of the spleen is removed. (africainfoline.com)
  • Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. (childrensmercy.org)
  • Partial splenectomy for massive splenomegaly secondary to Gaucher's disease. (bmj.com)
Laparoscopic Splenectomy8
  • Laparoscopic splenectomy is surgery to take out all or part of your spleen. (drugs.com)
  • Laparoscopic splenectomy - Once you are placed under general anesthesia, your doctor places an inflatable cannula (tube) into your abdomen to make room to operate. (templehealth.org)
  • higher rate of complications in patients with malignant dis- Laparoscopic splenectomy is associated with better out- ease, but the operative approach was not a predictor of mor- comes than open splenectomy and has become the standard bidity or mortality. (deepdyve.com)
  • higher rate of complications in patients with malignant dis- Laparoscopic splenectomy is associated with better out- ease, but the operative approach was not a. (deepdyve.com)
  • Most patients can have a laparoscopic splenectomy. (ocroboticsurgery.com)
  • After a laparoscopic splenectomy, you can expect to spend 1-2 days in the hospital. (somersetsurgicalassociates.com)
  • Laparoscopic splenectomy (LS) is the gold standard procedure to remove the spleen in elective patient, but remains a very delicate procedure due to fragility of parenchyma and capsule of the spleen and its close connections with stomach, pancreas and colon. (drtahermithi.com)
  • Laparoscopic splenectomy first started in the early nineties, but due to the lack of an acceptable conversion rate, it was not accepted by most of the laparoscopic surgeons. (drtahermithi.com)
Surgery9
  • Post-splenectomy complications can occur after surgery to remove the spleen. (medlineplus.gov)
  • Open splenectomy - Obesity, scar tissue or other conditions can make traditional surgery necessary. (templehealth.org)
  • data from the American College of Surgeons National Surgi- In this issue of JAMA Surgery, Bagrodia and colleagues cal Quality Improvement Program, reported that laparo- report their use of the American College of Surgeons National scopic splenectomy was associated with better outcomes Surgical Quality Improvement Program database to evaluate than open splenectomy, irrespective of the indication for clinical and pathologic vari- splenectomy. (deepdyve.com)
  • One or more large cysts or tumors on the spleen, even if they are benign, may necessitate a splenectomy since it may be impossible to remove them without this surgery. (anaheimsurgical.com)
  • Splenectomies may be performed as open surgery or laparoscopically, if the spleen has not become too enlarged. (anaheimsurgical.com)
  • A splenectomy is surgery that removes the entire spleen, a delicate organ that sits beneath the left rib cage near the stomach and is the size of a fist. (africainfoline.com)
  • There are only few Surgeons in Lagos doing Splenectomy surgery. (africainfoline.com)
  • You need to get detailed second opinion from experienced Surgeon in Lagos before deciding on Splenectomy surgery. (africainfoline.com)
  • Surgery to remove the spleen (splenectomy) cures the anemia but doesn't correct the abnormal cell shape. (health32.com)
Splenic2
  • In dogs, the most common indications for splenectomy include splenic tumors, splenic torsion, which is twisting of the blood vessels supplying the spleen, and trauma to the spleen. (petplace.com)
  • We diagnosed splenic metastasis of gastric cancer, and performed a splenectomy. (biomedcentral.com)
Recovery from a splenectomy2
  • Recovery from a splenectomy varies depending on the patient's overall physical condition. (anaheimsurgical.com)
  • Statistics show that health risks after recovery from a splenectomy are greater during the first two post-surgical years and that children who have had the procedure are at greater risks than adults. (anaheimsurgical.com)
Undergone3
  • Neutrophil chemotaxis and phagocytosis in the presence of serum from 20 patients who had undergone splenectomy and from 15 healthy volunteers was studied. (bmj.com)
  • Methods: All consecutive Japanese patients with hepatic cirrhosis due to hepatitis C who had undergone elective splenectomy in Kyushu University Hospital between January 2008 and December 2009 were included in this retrospective study. (elsevier.com)
  • Children who have undergone splenectomy may develop impaired immunologic function and heightened risk of overwhelming postsplenectomy infection. (aku.edu)
Infection5
  • Infection (rare) - If your spleen is infected, doctors may advise splenectomy. (templehealth.org)
  • If an abscess develops on the spleen, a splenectomy may be performed to remove the source of infection. (anaheimsurgical.com)
  • Possible risks following a splenectomy include bleeding, infection and a negative reaction to the anesthesia. (orangecountysurgeons.org)
  • If you develop a serious infection in your spleen or need treatment for certain cancers, you may need a surgical procedure known as a splenectomy. (somersetsurgicalassociates.com)
  • Children should wait until age 5 to have splenectomy because of the infection risk. (health32.com)
Year after splenectomy2
  • Conclusion: Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. (elsevier.com)
  • Although most presented during the first year after splenectomy, many (62%) sepsis events occurred later, suggesting that postsplenectomy immunologic dysfunction persists beyond one year. (aku.edu)
General anesthesia2
  • A splenectomy is performed under general anesthesia, which means that the patient is asleep and completely unaware during the procedure. (orangecountysurgeons.org)
  • Your Somerset Surgical Associates, LLC, surgeon provides general anesthesia during a splenectomy to help you sleep comfortably and be pain-free. (somersetsurgicalassociates.com)
Complications4
  • 8 g/dL) and symptoms and complications of HS should undergo splenectomy. (medscape.com)
  • Elective Splenectomy for Hematologic Diseases Arcelus, Juan I. 2014-10-01 00:00:00 Research Original Investigation Morbidity and Mortality Following Elective Splenectomy Invited Commentary Can We Predict Complications? (deepdyve.com)
  • Research Original Investigation Morbidity and Mortality Following Elective Splenectomy Invited Commentary Can We Predict Complications? (deepdyve.com)
  • Keith McCrae, MD, of the Cleveland Clinic, offers his thoughts on abstract 232, "Long-Term Complications After Splenectomy in Adult Chronic Immune Thrombocytopenia With a Minimum Follow-up of 10 Years. (ascopost.com)
Splenomegaly2
  • Splenectomy may be considered in certain individuals to determine the etiology of splenomegaly, though early diagnostic splenectomy is rarely indicated. (medscape.com)
  • HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C. (elsevier.com)
Require splenectomy2
  • Also, hereditary (genetic) conditions that affect the shape of red blood cells, conditions known as spherocystosis, sickle cell disease or thalassemia, may require splenectomy. (ocroboticsurgery.com)
  • As a result, males may be more likely to have extramedullary hematopoiesis and thus more likely to require splenectomy or to develop spinal cord compression, an uncommon but serious complication of paraspinal extramedullary hematopoiesis. (medscape.com)
Undergo splenectomy1
  • A longitudinal study was conducted for 5 years to observe the growth profile of Thalassemia children who had to undergo splenectomy. (jpai.in)
Elective Splenectomy1
  • ables associated with 30-day Bagrodia and coworkers do not provide information on morbidity and mortality af- the influence of other factors such as spleen weight or sur- Related article page 1022 ter elective splenectomy for geon experience. (deepdyve.com)
Hematopoietic stem cell trans1
  • Additional therapies include splenectomy, administration of immunomodulatory agents, and hematopoietic stem cell transplantation. (medscape.com)
Indications1
  • Indications for splenectomy are not always clear. (medscape.com)
Hemolytic1
  • Corticosteroids and splenectomy constitute two important therapeutic modalities in the treatment of autoimmune hemolytic anemia. (jci.org)
Sepsis4
  • Fatal sepsis caused by capsulated organisms (eg, Streptococcus pneumoniae, Haemophilus influenzae ) is a recognized complication in children who have had a splenectomy. (medscape.com)
  • Incidence and risk factors for sepsis after childhood splenectomy" by Arin L. Madenci, Lindsey B. Armstrong et al. (aku.edu)
  • Among 195 children who underwent splenectomy, 7% (n = 13) were hospitalized with sepsis, with an incidence of 1.8 (95% CI = 1.0-3.1) events per 100 person-years. (aku.edu)
  • After adjusting for underlying diagnosis, older age at splenectomy (HR = 0.90 per year, 95% CI = 0.81-0.99) was associated with decreased hazard of sepsis. (aku.edu)
Minimally invasive1
  • At Somerset Surgical Associates, LLC, the experienced surgeons offer a minimally invasive splenectomy to remove damaged spleens before they rupture. (somersetsurgicalassociates.com)
Procedure2
  • Juan I. Arcelus, MD, PhD Splenectomy remains a common procedure for the manage- Bagrodia et al. (deepdyve.com)
  • In these cases, the splenectomy is an emergency surgical procedure because the internal bleeding caused by a ruptured spleen may be life-threatening. (anaheimsurgical.com)
Gastrectomy1
  • The metastasis occurred 1 year after gastrectomy, and a splenectomy resulted in a curative resection. (biomedcentral.com)
Corticosteroid2
  • These experiments clearly demonstrate that both corticosteroid therapy and splenectomy act to decrease the in vivo clearance of IgG-sensitized cells: only corticosteroids alter the clearance of IgM-sensitized erythrocytes. (jci.org)
  • In non-responders or those patients who have relapsed to the initial corticosteroid treatment, splenectomy is recommended. (bvsalud.org)
Organs2
Therapies1
  • If medical therapies fail, a splenectomy might prevent the need for blood transfusion. (templehealth.org)
Book an appointment2
  • Call the office in Somerville, New Jersey, to find out if you're a candidate for a splenectomy or book an appointment online today. (somersetsurgicalassociates.com)
  • Call Somerset Surgical Associates, LLC, to schedule a splenectomy consultation or book an appointment online today. (somersetsurgicalassociates.com)
Significantly5
  • RBC survival improves significantly after splenectomy but does not become absolutely normal. (medscape.com)
  • The mean distance migrated by normal neutrophils in the presence of serum from the patients after splenectomy was significantly less than that when normal serum was used (p less than 0.005). (bmj.com)
  • The percentage of neutrophils phagocytosing a yeast was also significantly reduced in the presence of serum from patients after splenectomy (p less than 0.02). (bmj.com)
  • Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. (elsevier.com)
  • Tumor volume was significantly larger in splenectomy group (p=0.013). (elsevier.com)
Organ3
  • Once your dog is stable for anesthesia, a splenectomy is done to remove the affected organ. (petplace.com)
  • A splenectomy is the surgical removal of your spleen - a blood-filtering abdominal organ. (templehealth.org)
  • A splenectomy is the surgical removal of the spleen, an organ that helps to regulate the composition of the blood and plays an important role in fighting infections. (anaheimsurgical.com)
Prognosis2
  • The prognosis for a positive end result following a splenectomy is good. (orangecountysurgeons.org)
  • The prognosis (outlook) after splenectomy is for a normal life and a normal life expectancy. (medicinenet.com)
Patients13
  • Vaccination against pneumococcus and H influenzae must be administered to patients prior to splenectomy and, indeed, probably to all patients with severe HS. (medscape.com)
  • From the literature, we reviewed 19 patients who received a curative splenectomy for isolated metastasis from gastric cancer. (biomedcentral.com)
  • Aim: Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial. (elsevier.com)
  • Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. (elsevier.com)
  • Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. (elsevier.com)
  • Find detailed reviews from past patients who has done Splenectomy in Lagos. (africainfoline.com)
  • Reviews from past patients for Splenectomy in Lagos are here. (africainfoline.com)
  • Find The Best Splenectomy Hospital in Lagos based on Rating and Reviews from past patients. (africainfoline.com)
  • Thalassaemia patients attending King Abdulaziz University Hospital were sequentially approached for en- rolment. (who.int)
  • Long-term follow up of autoimmune thrombocytopenic purpura (ATP) patients submitted to splenectomy. (bvsalud.org)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
  • Thrombopoietin agonist receptors (TAR) such as Eltrombopag and Romiplostim, are recommended for splenectomized patients at risk of bleeding and have relapsed or for patients who have splenectomy as a contraindication and have not responded to other treatments. (bvsalud.org)
  • Patients with true ITP refractory to splenectomy and short-term treatment with adrenocortical steroids may respond to Vincristine but the medicinal product is not recommended as primary treatment of this disorder. (heethealthcare.co.in)
Bacteria1
  • Splenectomy for children with HS should not be performed until the child is older than 6 years, to reduce the risk of infections with encapsulated bacteria. (medscape.com)
Thalassemia1
  • Some diseases, such as sickle cell disease, thalassemia and lupus, may result in the need for a splenectomy. (anaheimsurgical.com)
Treatment3
  • Splenectomy is the definitive treatment for HS. (medscape.com)
  • When solitary metastasis to the spleen is suspected during the postoperative follow-up of a patient with gastric cancer, a splenectomy is a potentially effective treatment. (biomedcentral.com)
  • The treatment of hereditary spherocytosis is to remove the spleen (splenectomy). (medicinenet.com)
Abstract1
  • abstract = "The purpose of this study was to investigate whether splenectomy influences the tumor growth and metastatic pattern in an orthotopic syngeneic murine pancreatic cancer model. (elsevier.com)
Patient2
  • More than 18 months after the splenectomy, the patient has had no evidence of recurrent gastric cancer. (biomedcentral.com)
  • An urgent laparotomy and splenectomy were also done after the patient developed severe abdominal compartment syndrome. (ajmc.com)
Removal2
  • Splenectomy is the medical term for the surgical removal of the spleen. (petplace.com)
  • A splenectomy is the surgical removal of the spleen in the upper left area of the abdomen. (orangecountysurgeons.org)
Remove1
Include1
  • Children who are candidates for splenectomy include those with severe HS requiring RBC transfusions and those with moderate HS who manifest growth failure or other signs and symptoms of anemia. (medscape.com)
Idiopathic1
  • Initial application - (idiopathic thrombocytopenic purpura - post-splenectomy) only from a haematologist. (pharmac.govt.nz)
Autoimmune1
  • Two things: Even after a splenectomy, you still have an autoimmune disorder (ITP antibodies) and/or the predisposition to acquire another one. (pdsa.org)
Rupture1
  • When the spleen enlarges it is more prone to rupture and a splenectomy may have to be performed. (anaheimsurgical.com)
Hospital1
Cancers1
  • Blood cancers, such as leukemia and lymphoma, as well as malignancies detected in the spleen itself, may necessitate a splenectomy. (anaheimsurgical.com)
Erythrocytes1
  • an atomic force microscopy study by Li et al found that after splenectomy, erythrocytes were larger but still spheroidal-shaped, with a disorganized membrane ultrastructure and reduced surface particle size. (medscape.com)
Symptoms1
  • [ 4 ] Except in the unusual autosomal recessive variant of HS, splenectomy usually eliminates hemolysis and the associated signs and symptoms. (medscape.com)
Survival1
  • Splenectomy led to an increased survival of IgG-coated cells and a sixfold increase in IgG C1-fixing sites was necessary in order to obtain similar rates of clearance in splenectomized and control animals. (jci.org)
Infections1
  • The increased tendency to infections after a splenectomy requires certain precautions. (anaheimsurgical.com)
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