An encapsulated lymphatic organ through which venous blood filters.
Surgical procedure involving either partial or entire removal of the spleen.
A congenital or acquired condition in which the SPLEEN is not in its normal anatomical position but moves about in the ABDOMEN. This is due to laxity or absence of suspensory ligaments which normally provide peritoneal attachments to keep the SPLEEN in a fixed position. Clinical symptoms include ABDOMINAL PAIN, splenic torsion and ISCHEMIA.
Enlargement of the spleen.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Tumors or cancer of the SPLEEN.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Substances that are recognized by the immune system and induce an immune reaction.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
The measurement of an organ in volume, mass, or heaviness.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antibodies produced by a single clone of cells.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Surgical removal of the thymus gland. (Dorland, 28th ed)
Elements of limited time intervals, contributing to particular results or situations.
The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
An increased reactivity to specific antigens mediated not by antibodies but by cells.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
Lymphoid tissue on the mucosa of the small intestine.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.
Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)
Benzene derivatives which are substituted with three nitro groups in any position.
Progenitor cells from which all blood cells derive.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. It includes MACROPHAGES and their precursors; PHAGOCYTES; KUPFFER CELLS; HISTIOCYTES; DENDRITIC CELLS; LANGERHANS CELLS; and MICROGLIA. The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (From Illustrated Dictionary of Immunology, 2d ed.)
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.

Intensive investigation in management of Hodgkin's disease. (1/20402)

Ninety-eight patients with clinically localised Hodgkin's disease underwent laparotomy and splenectomy to determine the extent of microscopic spread. In 68 patients the procedure was carried out for untreated disease apparently confined above the diaphragm. Abdominal disease cannot be confidently excluded on the basis of non-invasive investigation at presentation. Clinical assessment of splenic disease was unreliable unless gross splenomegaly was present. Pedal lymphography was accurate in assessing para-aortic and iliac disease but of no value in assessing other intra-abdominal lymph node involvement, including that of the mesenteric lymph node. Trephine bone marrow biopsy findings were normal in all patients before surgery, and only one patient was found to have diseased bone marrow by Stryker-saw biopsy at operation. Liver disease was identified at operation in nine patients, some of whom were asymptomatic with clinically undetectable splenic and nodal disease. Detailed clinical staging failed to detect disease in one-third of patients who underwent laparotomy. These studies show that if radiotherapy is to remain the treatment of choice for disease truly localised to lymph nodes a detailed staging procedure, including laparotomy and splenectomy, remains essential. The value of this potentially curative treatment is considerably diminished in the patient who has been inadequately staged.  (+info)

Mercury and Mink. II. Experimental methyl mercury intoxication. (2/20402)

Adult female mink were fed rations containing 1.1, 1.8, 4.8, 8.3 and 15.0 ppm mercury as methyl mercury chloride over a 93 day period. Histopathological evidence of injury was present in all groups. Mink fed rations containing 1.8 to 15.0 ppm mercury developed clinical intoxication within the experimental period. The rapidity of onset of clinical intoxication was directly related to the mercury content of the ration. Mercury concentration in tissue of mink which died were similar, despite differences in mercury content of the diets and time of death. The average mercury concentration in the brain of mink which died was 11.9 ppm. The lesions of methyl mercury poisoning are described and criteria for diagnosis are discussed.  (+info)

Pathological changes in chickens, ducks and turkeys fed high levels of rapeseed oil. (3/20402)

Rations containing 25% of either regular rapeseed oil (36% erucic acid), Oro rapeseed oil (1.9% erucic acid), soybean oil or a mixture of lard and corn oil were fed to chickens, ducks and turkeys. The regular rapeseed oil ration caused growth depression, increased feed conversion and anemia in all species. All the ducks and some of the chickens fed the regular rapeseed oil ration died. These dead birds were affected with hydropericardium and ascites. No deaths in the turkeys could be attributed to the regular rapeseed oil ration but some turkeys fed this ration had degenerative foci characterized by infiltrations of histiocytic and giant cells in the myocardium. Severe fatty change in the heart, skeletal muscles, spleen and kidney was found at an early age in all birds fed the regular rapeseed oil ration. Less severe fatty change but no other lesions were found in birds fed the Oro rapeseed oil and soybean oil rations.  (+info)

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum. (4/20402)

Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.  (+info)

Suppression of Moloney sarcoma virus immunity following sensitization with attenuated virus. (5/20402)

Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of normal adult BALB/c mice with attenuated MSV-M resulted in an altered pattern of tumor immunity. Injection of active MSV-M into the presensitized animals resulted in tumor induction and rejection similar to that observed in normal animals, but rejection failed to produce protection against the secondary inoculation with MSV-M. After the second inoculation with active MSV-M, tumors appeared and progressed but ultimately were rejected. Over 80% of the mice died, 25% after the primary challenge and the remainder after the secondary challenge. At death, all mice had histological evidence of leukemia which was the probable cause of death. The animals that died following the secondary challenge also had evidence of disseminated MSV-M. Solid tumor nodules were found in skeletal muscle distant from the original site of inoculation, and active MSV-M was isolated from spleen and lungs. The possibility that the results were produced by specific suppression of MSV-Moloney leukemia virus immunity is discussed.  (+info)

Effect of portal-systemic anastomosis on renal haemodynamics in cirrhosis. (6/20402)

In 12 patients with portal hypertension and repeated bleedings from oesophageal varices the central haemodynamics, portal pressure, and mean renal blood flow (RBF) were investigated immediately before and two to seven months after portal-systemic shunt. Cardiac output increased significantly, whereas arterial pressure was unchanged after operation. RBF, which was initially less than in controls, did not change. As portal pressure decreased significantly, a direct portal-renal, neural, or humoral reflex mechanism does not explain the subnormal RBF in cirrhosis. As plasma volume was large and unchanged after operation a "diminished circulating plasma volume" is an unlikely explanation. Therefore, on the basis of the present observations, previously postulated causes of renal hypoperfusion in cirrhosis need revision.  (+info)

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (7/20402)

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

Systemic administration of rIL-12 synergistically enhances the therapeutic effect of a TNF gene-transduced cancer vaccine. (8/20402)

Interleukin-12 (IL-12) is a potent antitumor cytokine, which induces and enhances the activity of natural killer (NK) cells, lymphokine activated killer (LAK) cells and cytotoxic T lymphocytes (CTL). IL-12 also stimulates IFN-gamma production from both T cells and NK cells. In this study, we transfected methylcholanthrene-induced fibrosarcoma (MCA-D) with TNF gene and investigated the therapeutic effect of TNF gene-transduced cancer vaccine and whether the vaccination effect is enhanced by systemic administration of recombinant IL-12 (rIL-12), in a murine model. TNF gene-transduced cancer vaccine or systemic administration of rIL-12 showed slight or moderate inhibition of pre-established tumor. However, simultaneous application of the vaccine and rIL-12 resulted in complete eradication. The cytotoxicity of CTL against parental tumor cells was enhanced with the combination of the vaccine and rIL-12, and IFN-gamma production from spleen cells also increased synergistically. Our findings show that synergistic enhancement of CTL activity and IFN-gamma production could play an important role in the antitumor effect of combination therapy using TNF gene-transduced cancer vaccine and rIL-12.  (+info)

OBJECTIVE: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years.,br/, METHODS: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only.,br/, RESULTS: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm.,br/, CONCLUSION: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.,br/, ...
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TY - JOUR. T1 - Derivation of a brain tumor-selective monoclonal antibody from hybridoma between mouse myeloma and rat spleen cells immune to syngeneic glioma. AU - Saya, Hideyuki. AU - Masuko, Takashi. AU - Hashimoto, Yoshiyuki. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Fischer 344 (F344) rats hyperimmunized with syngeneic 9L/R, glioma cells produced antibody selective to glioma cells. Hybridomas prepared from the spleen cells of the immunized rat were cloned, and we obtained a hybridoma clone which produced monoclonal IgM antibody, termed FR77, that showed selectivity to glioma cells. Immunoperoxidase staining of cultured cells revealed that FR77 was reactive with 3 lines of rat glioma cells but not with normal F344 rat fibroblasts. Immuno-histochemical staining of F344 rat tissue sections with biotinylated FR77 demonstrated that FR77 could bind with glioma tissue developed by intracerebral injection of 9L/R, glioma cells but not to normal parts of the brain tissues and other normal tissues tested. ...
Limiting dilution analyses with the Poisson model were performed on normal mouse spleen cells alone or in the presence of added cells or soluble factors. When a constant number of T cells activated to sheep red blood cells were added to cultures of diluted spleen cells the mean frequency of response to sheep red blood cells was 5- to 30-fold greater than that of spleen cells diluted alone. Adding a constant number of B cells did not produce a significant change in the mean frequency of response of diluted spleen cells. Since a responding unit is thought to be composed of T cells and B cells, these results indicate that antigen-specific T cells normally limit the generation of responding units when normal spleen cells are subjected to limiting dilution analysis alone. Conversely, B cells appear to be in relative excess.. Culture medium supernatants from mixed cultures of T cells activated to histocompatibility antigens and target cells bearing the antigens to which the T cells have been activated ...
Spleen disorders are mainly a danger when left unaddressed. Although you can survive having you spleen removed (called a splenectomy), you might not be able to survive the causes of spleen disorders. That is why it is important to make an appointment with your doctor if you feel you may have a spleen condition. The purpose and function of the spleen. The spleen is a bodily organ that rests in the left side of the abdominal cavity, between the 9th to 12th ribs. The spleens central purpose is to get rid of old red blood cells, although it also functions as reservoir for blood in case you suddenly need it due to some sort of trauma.
Mugraby, L; Gery, I; and Sulitzeanu, D, Subpopulations of mouse spleen lymphocytes. Iii. Cellular inter- actions in the response to concanavalin a. (1975). Subject Strain Bibliography 1975. 1761 ...
The relative functional maturity of neonatal mouse spleen T- and B-cell populations was assessed by comparing the ability to respond to the thymic-independent antigen, DNP-Ficoll, or thymic-dependent SRBC by producing antibody in vitro. Although mouse spleen cells responded to DNP-Ficoll at an earlier age than they responded to SRBC or TNP-SRBC, the reason for the lag in the T-dependent response was confounded by the finding of high numbers of suppressor T lymphocytes in the neonatal spleen. Thus, small numbers of neonatal spleen T cells or thymocytes significantly decreased the in vitro antibody response of adult spleen cells. Although B lymphocytes appear to be functionally mature soon after birth, their acitivity may be modulated by an excess of suppressor T cells; e.g., the reconstitution of helper cell function in the neonatal spleen required anti-theta treatment before addition of adult helper cells. Suppressive activity attributable to T cells seems to play a dominant role in determining ...
The Spleen has a wide range of functions, from digestion to muscle tone to sensuality. The Spleen manufactures Qi from our food. The Spleens role is to transform and move foods, liquids, and thoughts in the body (i.e. digestion). For this reason the Spleen is called the source of postnatal energy (acquired Qi). It has a primary role in the lymphatic and immune systems. It keeps our tissues, muscles, and thoughts moist, supple, adaptable. The Spleen governs taste and true nourishment. It regulates bio-rhythms including menstruation. The Spleen stores Yi, consciousness of potentials, the ability to focus the mind sharply and keenly. A healthy spleen requires a stabile home environment. The Spleen harmonizes upper and lower parts of the body. Worry and over-thinking are the greatest causes of Spleen depletion.. The Spleen is the largest lymphatic organ, and plays an important part in the bodys immune system, by helping it to recognize foreign invaders. The spleen is responsible for the removal of ...
Question - Lesions on spleen, abdomen pain. Where can I find more information? . Ask a Doctor about diagnosis, treatment and medication for Flu, Ask a Gastroenterologist, Surgical
Header}} ==Introduction== [[File:Stage_22_image_085.jpg,thumb,300px,Developing Human Spleen ([[Carnegie stage 22,stage 22]])]] The {{spleen}} is located on the left side of the abdomen and has a role initially in blood and then immune system development. The spleens haematopoietic function (blood cell formation) is lost with embryo development and lymphoid precursor cells migrate into the developing organ. Mesoderm within the dorsal mesogastrium form a long strip of cells adjacent to the forming stomach above the developing pancreas. Vascularization of the spleen arises initially by branches from the dorsal aorta. The human spleen arises in week 5 within the dorsal mesentery as proliferating mesenchyme overlying the dorsal pancreatic endoderm. Cells required for its hemopoietic function arise from the yolk sac wall and near dorsal aorta. The spleen generates both red and white cells in the 2nd trimester. ,br> [[:Category:Spleen,Category:Spleen]] ,br> {{Heart Links}} ,br> {{Immune Links}} ,br> ...
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You will be placed under general anaesthesia and be completely asleep. A cannula (hollow tube) is placed into the abdomen by your surgeon and your abdomen will be inflated with carbon dioxide gas to create a space to operate. A laparoscope (a tiny telescope connected to a video camera) is put through one of the cannulas which projects a video picture of the internal organs and spleen on a television monitor. Several cannulas are placed in different locations on your abdomen to allow your surgeon to place instruments inside your belly to work and remove your spleen. A search for accessory (additional) spleens and then removal of these extra spleens will be done since 15% of people have small, extra spleens. After the spleen is cut from all that it is connected to, it is placed inside a special bag. The bag with the spleen inside is pulled up into one of the small, but largest incisions on your abdomen. The spleen is broken up into small pieces (morcelated) within the special bag and completely ...
I dont know about spleen, but I think Ill have to try out that neatloaf recipe. Of course, pig spleen could be another good gluten-free alternative to Special K for all we know, but then it would no longer be vegetarian. Ill just assume pig spleen is a better weather predictor than dinner ingredient and stick with the recipe as it is for now. ...
In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments.Whole embryonic day 15 (ED15) spleens, grafted under the kidney capsule of adult mice, were colonized by host-derived lymphocytes and DC and developed normal splenic architecture. Grafts were also able to form germinal centers in response to T-dependent antigen. Using this system we demonstrated that adult host-derived lymphotoxin (LT) a was sufficient for the development of ED15 LTa/ grafts. Grafting of ED15 LTa/ spleens into RAG/ hosts followed by transfer of LT a/ splenocytes revealed no requirement for lymphocyte-derived LT a in the induction of CCL21 or the development of T-zone stroma. These data suggest that interactions between adult lymphoid-tissue inducer-like cells and embryonic stromal cells initiated T-zone development. Furthermore,adult ...
TNF-α production in vitro by spleen mononuclear cells from IL-12 knockout mice (IL-12-/-) in comparison with cells from their wild-type littermates (IL-12+
1. The intracellular distribution of nitrogen, DPNH cytochrome c reductase, succinic dehydrogenase, and cytochrome c oxidase has been studied in fractions derived by differential centrifugation from rat and guinea pig spleen homogenates.. 2. In the spleens of each species, the nuclear fraction accounted for 40 to 50 per cent of the total nitrogen content of the homogenate, and the mitochondrial, microsome, and supernatant fractions contained about 8, 12, and 30 per cent of the total nitrogen, respectively.. 3. Per mg. of nitrogen, DPNH cytochrome c reductase was concentrated in the mitochondria and microsomes of both rat and guinea pig spleens. Seventy per cent of the total DPNH cytochrome c reductase activity was recovered in these two fractions. The reductase activity associated with the nuclear fraction was lowered markedly by isolating nuclei from rat spleens with the sucrose-CaCl2 layering technique. The lowered activity was accompanied by the recovery of about 90 per cent of the homogenate ...
Spleen cells may develop into insulin-producing pancreatic islet cells in adult animals, a breakthrough finding that could yield a potential cure for
The spleen was felt by the ancient Greeks and Romans to play a significant role in human physiology. Aristotle thought that the spleen was on the left side of the body as a counterweight to the right-sided liver.1 He believed that the spleen was important in drawing off residual humors from the stomach. The close relation of the stomach and spleen and the presence of the short gastric vessels so important in present-day splenic mobilization likely encouraged this belief. The spleen was also felt to hinder a mans running, and Pliny reportedly claimed that professed runners in the race that bee troubled with the splene, have a devise to burne and waste it with a hot yron.2 The exceptional speed of giraffes was felt to be related to the erroneous belief that giraffes were asplenic. Early references to removal of the spleen to increase speed make it apparent that it has long been known that the spleen is not absolutely necessary to sustain life. Paracelsus believed that the spleen could be ...
References for Abcams Mouse spleen tissue lysate - total protein (ab7937). Please let us know if you have used this product in your publication
Facts about swollen spleen symptoms. Often few swollen spleen symptoms appear in people suffering from an enlarged or damaged spleen. A swollen spleen is not a disease, but rather is a symptom caused by other underlying problems or disorders. However, an enlarged or damaged spleen can become a life-threatening problem, so recognizing swollen spleen symptoms and their underlying causes is important. The spleen is a fist sized organ located under the ribcage on the left side of the body. It sits next to the stomach and is an easily injured organ.
Capacity of ICSBP−/− spleen cells to transfer Listeria resistance to RAG2−/− mice. Non adherent spleen cells of ICSBP+/+ (open diamonds) or ICSBP−/−
Dupuy dangeac, A; Reme, T; Pla, M; and Colombani, J, Accessory function of a small radioresistant spleen cell population in the generation of t-cell-mediated cytotoxicity. (1982). Subject Strain Bibliography 1982. 2379 ...
Female mice were injected with a suspension of 0, 2 ml of 10 per cent v/v sheep red blood cells (SRBC) and sacrificed on the 5th day for recording of spleen mass and assay of plaque-forming cells (PFCs) in the spleens. All PFCs from a pool of five spleens and the individual spleen masses were subjected to rigid statistical analysis to verify whether differences from the control groups were significant (P , 0, 05). Three doses of 4 mg cortisol administered at 24-hourly intervals were given at various times relative to the time of immunization to determine the optimum stage at which to inhibit the formation of PFCs. The greatest inhibitory effect was obtained when the first dose was given at -6 h, with a lesser though still significant depression of PFCs with the -30 h dose regimen. Earlier and later injections had relatively little effect. An attempt was made to determine the response to different dosage levels by injecting doubling doses of steroid starting at the -6 h period. A maximal effect ...
DTA-1 mAb abrogates suppression mediated by CD4+ CD25+ T cells. (A) CD4+ CD25- or CD4+ CD25+ T cells (gated as a or b, respectively) were purified by cell-sorter from BALB/c spleen cells. (B) CD4+ CD25+ T cells (open square and closed square) or CD4+ CD25- T cells (open circle and closed circle) purified from 2-month-old BALB/c mice, or these two populations mixed in equal amounts (open triangle and closed triangle), were stimulated for 3 days along with MMC-treated spleen cells as APC in the absence or presence of graded amounts of DTA-1 mAb. Incorporation of [3H] thymidine by proliferating lymphocytes during the last 6 hr of the culture was measured. (C) Spleen cell suspensions prepared from 2-month-old BALB/c mouse were stained with anti-CD4, anti-CD25 and DTA-1. Expression of GITR (DTA-1) on CD4+ CD25+ T cells or CD4+ CD25- T cells is shown in the histogram. The dotted lines represent control staining with an irrelevant Ab.. ...
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According to Knowlton, spleen lacerations or ruptures typically take place from injury (like a car accident or contact sports). These emergency situations cause a break in the spleens surface and can result in severe internal bleeding and signs of shock (fast heart rate, dizziness, pale skin, fatigue), said Knowlton. The Mayo Clinic reported that without emergency situation care, the internal bleeding might end up being deadly.. On the continuum of spleen breakage, a laceration refers to a lower-grade extent of injury, in which just a part of the spleen is harmed. A burst spleen is the highest grade of broken spleen injury, inning accordance with HealthTap, an online network of physicians who respond to health questions.. According to Medical News Today, symptoms of a lacerated or burst spleen consist of pain or tenderness to the touch in the upper left part of the abdomen, left shoulder, and left chest wall, along with confusion and lightheadedness. If you experience any of the symptoms ...
Splenic T cells exposed to concanavalin A (Con A), and subsequently to factors produced by rat spleen cells in response to Con A (Con A sup), acquire the ability to function as helper T (TH) cells in response to xenogeneic erythrocytes (RBC). Help is measured as the reconstitution of the plaque-forming cell response of a spleen cell population depleted of T cells by treatment with anti-Thy-1 serum and complement. We propose that precursor TH cells differentiate during the in vitro treatment into mature TH cells. As differentiation occurs under limiting dilution conditions, an estimation of the precursor frequency should in principle be possible. However, a single-hit Poisson distribution does not fit our data. Instead, we observe, dependent on the T cell concentration, three separate peaks of response. In many experiments, using sheep, horse, and chicken RBC as antigens, we reproducibly find these peaks at 40-190, 600-3,000, and 20,000-100,000 T cells, placed into limiting dilution cultures, ...
You see, after a major battle, there would be hordes of dead bodies all over the place. Lying in the sun like that, the bodies would get all bloated as the gases inside built up, until they would explode, leaving the ground strewn with organs and viscera. It was quite messy, and extremely unhygenic. To deter this, the doctors would wander the battlefield, looking at bodies for signs of puffiness. They would then stab the body in the abdomen, allowing the noxious humors a means of escape. It was obviously known the the reason for the bloating was that dread spirits were taking up residence in the body. Where else would these vile demons go but the spleen? Thus, the term venting the spleen was born. Their scientific principles were not entirely sound ...
You see, after a major battle, there would be hordes of dead bodies all over the place. Lying in the sun like that, the bodies would get all bloated as the gases inside built up, until they would explode, leaving the ground strewn with organs and viscera. It was quite messy, and extremely unhygenic. To deter this, the doctors would wander the battlefield, looking at bodies for signs of puffiness. They would then stab the body in the abdomen, allowing the noxious humors a means of escape. It was obviously known the the reason for the bloating was that dread spirits were taking up residence in the body. Where else would these vile demons go but the spleen? Thus, the term venting the spleen was born. Their scientific principles were not entirely sound ...
BioAssay record AID 196412 submitted by ChEMBL: Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 10 uM; ND is not determined.
Early detection of problems which concern the spleen is highly critical because when these are just being left untreated, these may probably lead to life-threatening situations. The treatment for pain relating to the spleen would vary immensely depending on the underlying pathology. Before your physician would prescribe you a specific treatment, your exact condition must first be determined. For instance, when the splenic pain is primarily felt due to an underlying infection may entirely be treated with antibiotics. When for instance this is caused by the presence of tumor near the spleen, surgery, chemotherapy and other common ways of treating cancer may help palliate or perhaps treat the condition. However, when it is all due to a ruptured spleen, a splenectomy, which is the surgical removal of the spleen, may be indicated. This surgical procedure poses several risks though. Since the spleen has been already removed, the person this time becomes more susceptible to infections. Thus, vaccines ...
Enlarged Spleen is a disease of the Spleen. Spleen is present under the rib cage in the upper left part of the Abdomen. Its normal size is about that of a fist. But as a result of diseases the Spleen gets enlarged. The Spleen is part of the immune system. It filters the blood and acts as a reservoir. It produces lymphocytes, a type of white ...
The immature B cells that successfully make it through this process (only about 10%) enter into the bloodstream and migrate to the spleen. The immature B cells have both IgM and IgG (BCRs) expressed on their surface at this point and once they enter into the spleen are called transitional type 1 (T1) B cells. In the spleen B cells, T cells, and follicular dendritic cells, form what is known as a primary follicle or sometimes the white pulp (See Figure 2). The T1 B cells are located outside of the follicle (extrafollicular) in an area known as the red pulp (as this is where all of the red cells are flowing through the spleen). At this point, the T1 B cells are exposed to more self cells and circulating proteins and if they respond strongly it would indicate autoreactivity and the cells are typically induced to become T3 B cells, which are anergic (which means they become non-responsive to antigen), and will likely die off.. If the T1 B cells survive through this they can then migrate into the ...
I will be having a splenectomy in July and Im very nervous and scared about it. I never have surgery in my life. I am 44 years old female and always keeping up my healthy life style but for some unknown reason. The CT scan shown that I have lesion growing inside my spleen from a spot to 3.1cm in 2 years. I have been having 7 CT, 1 PET/CT and 1 MRI in the past 2 years. After reveiwing the recent CT, my surgeon determined that he will have to make about 3-6 incision in additional of 3 holes for laporascopic procedure so that he can take the whole spleen out through that incision. He gave me 2 options, 1 is to make an incision above the belly or he can make it on the bikini area to hide the scar. My question is, from your surgeon point of view. would it be more difficult to remote the spleen from bikini area than from the above belly button? I just dont want to add a complication by having him removed the spleen from the bikini area. The second question is, what will be the closing method use to ...
Ive been having abdominal spasms, and just got the results from my CT scan--I have a benign cyst on my spleen. The nurse said no treatment is necessary as long as it doesnt get any bigger (which is f...
Jason Witten wondered if his season was over before it ever began when doctors told the Dallas Cowboys star tight end that he had a lacerated spleen.
A joke blog to tickle your spleen (or spleens, since approximately 10% of people have one or more accessory spleens. They may form near the hilum of the main spleen, the junction at which the splenic vessels enter and leave the organ. --Wikipedia). ...
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This method allows you to isolate different subclass mononuclear cells, like B-cells, T cells, CD4+ and CD8+ T, from mouse spleen. By conjugating cells with specific antibodies and subsequently magnetic beads isolation, using the technique from Miltenyi, this allows a high purity.
What you should know about spleen function. Spleen function is probably not the first thing that you think of in the morning when you wake up. The spleen, however, is an important bodily organ. It serves a very important function in terms of keeping your body healthy. The spleen is the warehouse where old blood cells are held until theyre called upon to perform important bodily tasks like healing lacerations.
Looking for spleen? Find out information about spleen. soft, purplish-red organ that lies under the diaphragm on the left side of the abdominal cavity. The spleen acts as a filter against foreign organisms that... Explanation of spleen
The anti-tumor effect of syngeneic spleen cells, xenogeneic immune RNA (l-RNA) and tumor antigen (TA) was studied in a chemically induced (N-methyl-N-nitro-sourethane) colon carcinoma model in BALB/c mice. When the mice were treated, sequentially, with these three elements by local injection under the tumor, complete tumor regression was observed in 25% of the animals. Complete tumor regression was observed in 17% of animals treated by injection of spleen cells pre-incubated with l-RNA in vitro followed by an injection of TA. When spleen cells were treated first with l-RNA and then with mitomycin-C, therapeutic benefit was obtained and the survival rate of mice treated with these spleen cells and TA was significantly higher than that of the control group (no treatment). The anti-tumor effect of this treatment was abrogated completely when spleen cells were treated with mitomycin-C prior to l-RNA incubation. When spleen cells were incubated with TA in vitro or after incubation with l-RNA and then ...
The spleen is the organ located above the stomach and under the ribs, which is responsible for fighting infection and balancing the fluids in the body. Spleen problems range from mild to severe and life-threatening. One of the most common spleen-related problems is splenomegaly, or an enlarged spleen --- may be caused by numerous factors, states, including mononucleosis, bacterial infections, malaria, liver cirrhosis, destruction of red blood cells or hemolytic anemia, blood cancers, pressure on your spleen veins and certain metabolic disorders.
Four different combinations of F1 hybrid mice [(C57BL/10 X B10.A)F1, (C57BL/10 X B10.BR)F1, B6D2F1, and AKD2F1] were injected intravenously with spleen cells from parental strains. The T-cell-mediated cytotoxic potential of spleen cells from the injected F1 mice was assessed from 4 to 21 d later by in vitro sensitization with trinitrophenyl-modified parental or syngeneic F1 spleen cells (TNP-self) or with allogeneic spleen cells. The cytotoxic potential of the F1 mice to TNP-self as well as to alloantigens was abolished or severely depressed throughout this period when the respective H-2k,a,d parental spleen cells were injected. In contrast, the cytotoxic potential was unaffected or only marginally reduced when H-2b parental cells were injected. The induction of depressed cytotoxic activity was shown to be a result of a population of parental radiosensitive T lymphocytes. The results should be discussed with respect to (a) the genetic and mechanistic parameters associated with the differential ...
Light microscopy of primate spleen showing white pulp (blue) and red pulp (pink). The spleen is part of the bodys immune system and classified as a lymphoid organ. It filters blood and serves to screen the blood for the presence of foreign antigens that may be a threat to the bodys health. The red pulp is formed like a sieve through which blood vessels pass. The white pulp is formed of lymphoid cells, mainly lymphocytes, which initiate an immune response if harmful agents in the blood are detected. The spleen also removes and destroys worn out red blood cells. Magnification x9 when printed at 10 cm. - Stock Image C024/0095
A joke blog to tickle your spleen (or spleens, since approximately 10% of people have one or more accessory spleens. They may form near the hilum of the main spleen, the junction at which the splenic vessels enter and leave the organ. --Wikipedia). ...
BioAssay record AID 409783 submitted by ChEMBL: Increase in 2-arachidonoylglycerol level in Swiss-Webster mouse spleen at 10 mg/kg, ip after 4 hrs relative to control.
The immunogenesis of the human fetus has been investigated by means of the formation of immunoglobulins in vitro, immunofluorescence, morphological studies, and analysis of the immunoglobulins in the serum. Twenty fetuses which were born alive but died soon after delivery, were studied; their ages ranged from 13 to 31 weeks. The results of the spleen cultures demonstrated the synthesis of IgG and IgM, which starts at about the twentieth week of gestation. In the serum, IgM could be detected at about the same period. The immunofluorescent staining of the spleen tissue showed that medium sized and large lymphoid cells as well as plasma cells, even with Russell bodies, were positive for either IgG or IgM. The peripheral blood was also found to contain a small number of medium sized IgG and IgM-positive cells. Both the spleen and the peripheral blood showed a considerable number of fluorescent small lymphocytes which exclusively contained IgM. The relatively high ratio of IgM to IgG production ...
For a recent practical I had to investigate different cell populations in a mouse spleen cell suspension which present MHC class II molecules. 2 antibodies were used-rabbit IG which is specifically anti-mouse Ig, and mouse Ig which specifically binds MHC class II ...
There is an 80s revival happening in music these days. No, this isnt necessarily news unto self. After all, bands like Metric have been enjoying massive success with a sound as rooted in the modern day as it is in the past.. Ottawa-based band Silvergun & Spleen are set to release their full-length debut Semi Truck next Tuesday (September 11). Owing as much to the 80s as any of their contemporaries twice their age, the bands blend of electro-pop is pretty damn infectious.. Silvergun & Spleen are comprised of siblings Marie-Eve Mallet and Veronique Mallet along with John Lenherr and bassist Chris Page-Manson.. Last week, S&S vocalist-guitarist Marie-Eve took the time to chat with The Musicnerd Chronicles last about the groups new record and why the 80s werent so bad in hindsight.. How do you feel the band has grown since the release of your 2011 EP Through My Skeleton? Mallet: I think some of the most noticeable differences that we see is around the fact that we were more willing to ...
An accessory spleen is a small splenic nodule extra to the spleen usually formed in early embryogenesis. Accessory spleens are ... "Spleen Diseases" from MedlinePlus "Finally, the Spleen Gets Some Respect" - The New York Times Normal range of spleen size for ... In humans, the spleen is purple in color and is in the left upper quadrant of the abdomen. The spleen is underneath the left ... An easy way to remember the anatomy of the spleen is the 1×3×5×7×9×10×11 rule. The spleen is 1 by 3 by 5 inches (3 by 8 by 13 ...
"Spleen United". " - Discography Spleen United". Hitlisten. Hung Medien. Retrieved 6 August 2011. "Guld og platin ... Official site Copenhagen Records page for Spleen United Myspace profile Facebook profile Spleen United discography at Discogs v ... Spleen United is a Danish electronic rock band consisting of the brothers Bjarke (Vocals/Guitar) and Gaute Niemann (Bass/ Synth ... From 16 to 17 April 2010, Spleen United held a non-stop 24-hour improv session - from sunset to sunset. They put up a mini-site ...
... (born Richard Shaw) is a character in the BBC situation comedy Lead Balloon, played by comedian Jack Dee. Spleen is ... Spleen is upset but tries not to let his feelings show. However, Marty returns and decides to continue writing with Spleen. ... Spleen often makes fun and insults his American writer Marty, and Marty returns the gesture. However, it is made clear that the ... For example, when Spleen has an argument with Michael, the café owner, or with Magda, his Eastern-European cleaner, Marty ...
... (EC, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase ... Spleen+exonuclease at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Articles with ... Bernardi A, Bernardi G (1971). "Spleen acid nuclease". In Boyer PD (ed.). The Enzymes. Vol. 4 (3rd ed.). New York: Academic ...
... (or pelvic spleen) is a rare medical disease caused by the loss or weakening of the ligaments that help to ... Although symptoms include an enlargement in the size of the spleen, or a change from the spleen's original position to another ... The usual treatment is splenopexy, fixation of the spleen, but if there is no blood flow after unwinding the spleen through ... Wandering spleen (splenoptosis) predisposes the spleen to complications such as torsion, splenic infarction, pancreatic ...
... is a pain felt from the left upper quadrant of the abdomen or epigastrium where the human spleen is located or ... Some patients also report pleuritic left-sided chest pain in the setting of a ruptured spleen. Caution should be used early in ... Articles with short description, Short description matches Wikidata, Spleen (anatomy)). ... which also causes spleen pain, from blunt trauma, resulting in life-threatening internal bleeding. Many conditions can cause ...
Splenectomy - Surgical removal of the spleen Accessory spleen - Small nodule found apart from the main body of the spleen ... Spleen transplantation is the transfer of spleen or its fragments from one individual to another. It is under research for ... the spleen harbors primitive hematopoietic progenitor cells. Spleen transplantation has been performed on humans with mixed ... Recently, evidence has been obtained for a tolerogenic effect of a spleen transplant in miniature swine.[citation needed] Also ...
An accessory spleen is a small nodule of splenic tissue found apart from the main body of the spleen. Accessory spleens are ... Polysplenia is the presence of multiple accessory spleens rather than one normal spleen. Accessory spleens may be formed during ... The most common locations for accessory spleens are the hilum of the spleen and adjacent to the tail of the pancreas. They may ... Histologic section of an accessory spleen Ultrasonography of an accessory spleen. If splenectomy is performed for conditions in ...
Look up spleen in Wiktionary, the free dictionary. The spleen is an organ in the human body. Spleen may also refer to: Spleen, ... "Spleen", a song by Staind from Dysfunction Splean This disambiguation page lists articles associated with the title Spleen. If ... poem by Baudelaire Spleen (Chinese medicine), an element of body function A French rapper/musician who sometimes performs with ...
"Chateau Chasse-Spleen". Downton Abbey, Season 6, Episode 6. Carson brings some Chateau Chasse-Spleen to a bed ridden Robert ... A second wine is produced under the label L'Héritage de Chasse-Spleen and another titled l'Oratoire de Chasse-Spleen. Long ... and of the two second wines L'Héritage de Chasse-Spleen and l'Oratoire de Chasse-Spleen, there is produced approximately 14,000 ... "Quel remede pour chasser le spleen", or alternately attributed to the poem Spleen whose author Charles Baudelaire once visited ...
The Spleen's function (i.e., the Spleen-qì) is said to be strongest between 9 and 11am. When the Spleen is functioning well, ... As a zàng, the Spleen is considered to be a yin organ. Its associated yang organ is the Stomach. Both Spleen and Stomach are ... The Spleen is especially weakened by the Pathogenic Factor ''Dampness''. "TCM: Understanding The Role Of The Spleen". www. ... Wu, Xie-Ning (1998-02-15). "Current concept of Spleen-Stomach theory and Spleen deficiency syndrome in TCM". World Journal of ...
... constitute the frame-work of the spleen. The spleen therefore consists of a number of small spaces or areolae, formed by the ... Spleen Trabecula This article incorporates text in the public domain from page 1283 of the 20th edition of Gray's Anatomy (1918 ... The fibroelastic coat of the spleen invests the organ, and at the hilum is reflected inward upon the vessels in the form of ... v t e Portal: Anatomy (Wikipedia articles incorporating text from the 20th edition of Gray's Anatomy (1918), Spleen (anatomy), ...
... at the Dead Can Dance official website Spleen and Ideal at MusicBrainz (list of releases) (EngvarB from July ... "Dead Can Dance , Spleen and Ideal". 25 November 2019. Retrieved 27 January 2022. "Dead Can Dance , Spleen and ... "Dead Can Dance , Spleen and Ideal". 25 November 2019. Retrieved 27 January 2022. Raggett, Ned. "Spleen and Ideal ... Spleen and Ideal is the second studio album by Australian band Dead Can Dance. It was released on 25 November 1985 by 4AD. The ...
... , also known as Paris Spleen or Petits Poèmes en prose, is a collection of 50 short prose poems by Charles ... Le Spleen de Paris: Full online downloadable text Lo Spleen di Parigi: Italian translation online Baudelaire, Charles (1970) [ ... In Le Spleen de Paris, the concept of artist and poet intermingle. Baudelaire saw poetry as a form of art, and thus in many of ... Le Spleen de Paris represents a definitive break from traditional poetic forms. The text is composed of "prose poems" which ...
"Spleen", published posthumously in 1869. The final line is "Où coule au lieu de sang l'eau verte du Léthé" which one translator ... "Spleen." Charles Baudelaire's Fleurs De Mal / Flowers of Evil, Fleurs de Mal. 1869. Accessed ...
The tissue distribution, measured in terms of AUC0→4h values, follows kidney > spleen> liver > heart > lung> brain. Using ...
ISBN 978-1-119-05817-5. Salústio, Dina (1998). A louca de Serrano (in Portuguese). Edições Spleen. Salústio, Dina (2020-04-20 ...
Baudelaire, Charles (2021) [1869]. Paris Spleen. New York: Contra Mundum Press. p. 142. ISBN 9781940625454. Benoît, Christian ( ... in Paris Spleen "L. In Praise of Dogs" Nestor Roqueplan, the Goncourt brothers, Paul de Kock, Alexandre Dumas fils, and Henri ...
Spleen appears. Ureteric buds appear. Gestational age: 6 weeks and 0 days until 6 weeks and 6 days old. 43-49 days from last ...
His resulting injuries commonly leave him uttering some variation of the phrase, "AHHHH! MY SPLEEN!" He also is quite often ...
"Screen Spleen." The Chronicle Review, March 18, 2013 Jesper Juul's website. Jesper Juul's CV. The Ludologist Blog. Website for ... Ayoub, Nina C. "Screen Spleen". The Chronicle Review March 18, 2013. "Game Studies 1/1". Retrieved 2014-02-18. "2010 IGF Nuovo ...
Same spleen. Same pancreas. Same number of lobes in each lung. Pericardium attached to diaphragm. More rounded apex of the ...
Montville, Leigh (19 April 1993). "Spleen For Green". Sports Illustrated. Retrieved 31 December 2013. Mary Ellen Egan (11 ...
1946 Les Joueurs; Femme en Vert; Grenades; Masque 1947 La Pianiste; Christ I; Duo; Spleen 1949 Arlequin; La Fenetre; L'Oiseau ... 1950 Nu; La Table; La Printemps Hollandais; Grand Spleen 1951 Baladins; Tete de Femme; Clown Bleu; Christ II; La Pendule 1952 ...
"Spleen for Green". Sports Illustrated. April 19, 1993. Retrieved 2009-04-21. Rusty Burson; Glenn Hart (1 March 2011). The Lone ...
Spleen of Ramos; Fifteenth Pick; Squizzle, Goblin Nabizzle; Zombie Cheerleading Squad; Two-Way Myr; Bone Flute 2: Electric ...
Montville, Leigh (April 19, 1993). "Spleen for Green". Sports Illustrated. Retrieved May 12, 2011. Willes, Ed (2004). The Rebel ...
"Chateau Chasse-Spleen". Archived from the original on 2007-12-23. Retrieved 2007-12-16. Kissack, Chris, " ...
Spleen: white pulp depletion. Preventive measures to reduce the chances of infection include getting vaccinated, staying at ...
Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c ...
Spleen removal is surgery to remove a diseased or damaged spleen. This surgery is called splenectomy. ... The spleen is in the upper part of the belly, on the left side underneath the ribcage. The spleen helps the body fight germs ... Spleen removal is surgery to remove a diseased or damaged spleen. This surgery is called splenectomy. ... During open spleen removal:. *The surgeon makes a cut (incision) in the middle of the belly or on the left side of the belly ...
Immunoplasts in the periarteriolar sheath of the spleen. Image courtesy of Sherif R. Zaki, M.D., Ph.D. ... Immunoblasts in the Periarteriolar Sheath of the Spleen. ...
Spongy inner tissue within the spleen contains many tiny blood vessels and hollow sinuses that store blood. The spleen can ... The spleen is not a vital organ - its functions are useful but not essential for life. Red bone marrow, the liver, and lymph ... The spleen is a brown, flat, oval-shaped lymphatic organ that filters and stores blood to protect the body from infections and ... The spleen may enlarge during certain infections due to an increase in the number of white blood cells, captured pathogens and ...
Role of the spleen in the immunology of parasitic diseases : proceedings of the meeting held in Geneva, 12-14 June 1978  ... Biometric study of spleen and liver weights in Africans and Europeans with special reference to endemic malaria / by Jan Bruce- ... Ultrasound assessment of normal splenic length and spleen-to-kidney ratio in children  ...
What Does the Spleen Do?. The spleen acts as a filter. It weeds out old and damaged cells and helps control the amount of blood ... What Are the Spleen and Lymphatic System?. The spleen is located in the upper left part of the belly under the ribcage. It ... The spleen is part of the lymphatic system, which is an extensive drainage network. The lymphatic (lim-FAT-ik) system works to ... The spleen also helps get rid of germs. It contains white blood cells called lymphocytes and macrophages. These cells work to ...
Nurse calls this hospitals IT help desk at 2 a.m. about problems shes having with patient orders -- and shes way too busy to be more specific.
Spleen and Lymphatic System. What Are the Spleen and Lymphatic System?. The spleen is located in the upper left part of the ... What Does the Spleen Do?. The spleen acts as a filter. It weeds out old and damaged cells and helps control the amount of blood ... The spleen is part of the lymphatic system, which is an extensive drainage network. The lymphatic (lim-FAT-ik) system works to ... The spleen also helps get rid of germs. It contains white blood cells called lymphocytes and macrophages. These cells work to ...
Spontaneous rupture of the malarial spleen: two case reports and review of the literature. Crit Care. 2000;4:309-13. DOIPubMed ... An enlarged spleen is found in 50% to 80% of malaria patients (1), while only 25 cases of splenic rupture have been reported ... Spleen Abscess as Malaria Complication. Volume 12, Number 3-March 2006. Article Views: 336. Data is collected weekly and does ... After splenectomy, the spleens length was found to be 48 cm, and its weight was 6 kg. On histologic examination, splenic ...
Other disease blood/lymph/spleen. Known as: ANNEN SYKDOM I BLOD/LYMFE/MILT, Altra mal sangue/linfatici/milza, Out doencas ...
Spleen, White pulp - Atrophy in a female F344/N rat from a subchronic study. Overall area and cellularity of the white pulp ( ... Spleen - Atrophy in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). In addition to white ... Spleen - Atrophy in a female B6C3F1/N mouse from a subchronic study. Both red pulp (arrow) and white pulp (follicles, ... Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, ...
Spleen - A large dark-red oval organ on the left side of the body between the stomach and the diaphragm; produces cells ... Spleen. A large dark-red oval organ on the left side of the body between the stomach and the diaphragm; produces cells involved ...
Ben Swift ruptured his spleen after crashing on a training ride with teammate Geraint Thomas. ... They have stopped the bleed in the spleen. But just need to keep monitoring it. Along with that I have facial wounds and road ... The Brit added that his "spleen has been stabilized" and that he looks forward to competing at Milan-San Remo, a 185-mile ... The crash ruptured Swifts spleen and he required immediate surgery.. *Swift is stable now and recovering at a hospital in the ...
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Paris Spleen The Gentlemans Club EP. Chris Estey December 31, 2005. no Comments Tacoma band Paris Spleen, whose name suitably ...
Orlando Cop Found Guilty Of Battery After Rupturing Mans Spleen September 16, 2016. September 16, 2016. Asa J 802 Views ... ruptured spleen, Sgt. William Faulkner, spleen, surveillance video, video ...
An enlarged spleen (splenomegaly) can be caused by conditions such as viral or bacterial infections, cancers, inflammatory ... An enlarged spleen can cause liver disease, lupus, and mono.. *The spleen is an important organ in the immune system. It is a ... Enlarged Spleen (Splenomegaly) - Patient Experience Tell us about your experience with enlarged spleen (splenomegaly). ... Enlarged Spleen (Splenomegaly) - Symptoms What were the symptoms of your enlarged spleen? ...
... Liam Delahunty ldelahunty at Thu Dec 19 16:19:00 CST 2002 *Previous message: Semi- ...
People who dont have a spleen or who have a spleen that doesnt work well are at risk for serious infection. When infection ... The spleen plays an important role in your heath by helping your body fight infection. ... Summary of details regarding how spleen health impacts children treated for cancer, including tips for managing fever and ... When Your Spleen Doesnt Function Home. » Cancer Resources » Late Effects of Treatment for Childrens Cancer » When Your Spleen ...
You had surgery to remove your spleen. This operation is called splenectomy. Now that youre going home, follow your health ... After your spleen is removed, you will be more likely to get infections:. *For the first week after surgery, check your ... If your spleen was removed for a blood disorder or lymphoma, you may need more treatments. This depends on your medical ... Most people live a normal active life without a spleen. But there is always a risk of getting an infection. This is because the ...
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... and spleen (B) on CT images. from publication: Computed Tomography-Based Texture Features for the Risk Stratification of Portal ... FIGURE 2 , The delineation of the region of interest of the liver (A) and spleen (B) on CT images. ... The delineation of the region of interest of the liver (A) and spleen (B) on CT images. ... 1648839126503/The-delineation-of-the-region-of-interest-of-the-liver-A-and-spleen-B-on-CT-images.png alt=, The delineation of ...
Pig Spleen Total Protein from ZYAGEN. Cat Number: PT-701. UK & Europe Distribution. ... Pig Spleen Total Protein , PT-701 Zyagen Pig Total Protein Pig Spleen Total Protein , PT-701. (No reviews yet) Write a Review ... Pig Spleen Total Protein , PT-701 , Zyagen. Protein lysate is isolated from freshly harvested mammary gland. Tissues are ... Pig Spleen gDNA , PG-701 , ZyagenZyagen offers a pure and intact high molecular size control gDNA of 32 different plant species ...
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... for the Spleen, we generally emphasize Spleen-Qi and Spleen-Yang deficiency. ... When we study the pathology of the Internal Organs, for the Spleen, we generally emphasize Spleen-Qi deficiency and Spleen-Yang ... The Spleen controls yun hua, i.e. transportation and transformation of food essences. Yun Hua is impaired not only when Spleen- ... Spleen-Yin includes Blood and Ying and for this reason Spleen-Yin deficiency may cause bleeding such as in the stools, vomit or ...
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Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole ... Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole. *PDB DOI: 10.2210/pdb3FQH/pdb ... Spleen tyrosine kinase is considered an attractive drug target for the treatment of allergic and antibody mediated autoimmune ... Spleen tyrosine kinase is considered an attractive drug target for the treatment of allergic and antibody mediated autoimmune ...
SPLEEN → EARTH → SINGING → INTELLECT → TRANSFORMING → DIGESTION. Perhaps your acupuncturist mentioned something about spleen qi ... In Traditional Chinese Medicine, "spleen" refers to the functions of your spleen, pancreas, and the lymphatic system of the ... Fill your Spleen quota up every day by breathing in all that the Earth provides us. Reconnect with your center, your essence, ... Our Spleens, when out of balance, give way to ruminating, cyclic overthinking, and worry. When youre lying awake at night and ...
Spleen pain can be perceived on the left side of the abdomen. The pain is generally perceived on the upper left side of the... ... Spleen Pain Location, Signs and Symptoms, Treatment methods, Causes. ...
Bovine Spleen. Have questions about a product?. Contact us to learn more about Meridians molecular or immunoassay reagent ... Home » Life Science » Products » Antibodies & Antigens » Autoimmune » Bovine Spleen ...
Been Venting your Spleen? Thats Probably Why You Are Tired Ever hear that old phrase about "venting your spleen"? When I was ...
  • Hematoma or infarction of the spleen might be followed by the development of a splenic abscess, a clinical condition that has been reported in only 1 patient, to our knowledge ( 4 ). (
  • An enlarged spleen is found in 50% to 80% of malaria patients ( 1 ), while only 25 cases of splenic rupture have been reported since 1960 (0%-2% in natural occurring infection) ( 5 ). (
  • Indeed, splenic hematoma or infarction, together with the humoral and cellular immunodepression due to malaria, might well be predisposing factors for bacterial (e.g., salmonellae) colonization of the spleen from the gut, as likely happened in this patient, although cultures of the pus, blood, or intraabdominal fluid were not performed. (
  • Certain infections, diseases affecting blood cells, increased splenic blood flow, and diseases invading the spleen are some common reasons for the spleen to enlarge. (
  • In Traditional Chinese Medicine, "spleen" refers to the functions of your spleen, pancreas, and the lymphatic system of the body. (
  • Conditions related to the liver/biliary tract, pancreas, and spleen frequently are chronic in nature and difficult to diagnose. (
  • This week, as you examine the pre- and post-operative care of patients with conditions related to the liver/biliary tract, pancreas, and spleen, you explore strategies for assessment, diagnosis, and treatment. (
  • The liver/biliary tract, pancreas, and spleen often are associated with chronic conditions, which may result in long-term symptoms for patients. (
  • For this Assignment, as you examine this week's i-Human patient case study, consider how you might evaluate and treat pre- and post-operative patients who present with health conditions related to the liver/biliary tract, pancreas, and spleen. (
  • With the liver/biliary track, pancreas, and spleen in mind, consider how to assess, diagnose, and treat patients in pre- and post-operative care. (
  • Develop a treatment plan for the patient that includes health promotion and patient education strategies for medical and surgical patients with conditions of the liver/biliary tract, pancreas, and spleen. (
  • A total pancreatectomy is an operation to remove the entire pancreas and the spleen. (
  • Red bone marrow, the liver, and lymph nodes can complete the filtration and blood recycling functions of the spleen in its absence. (
  • Survivors who received high doses of radiation to the spleen or who have currently active chronic graft-versus-host disease (as a result of a bone marrow or stem cell transplant) are at risk for having a spleen that doesn't function well. (
  • West Nile Virus RNA was detected in samples from the spleen/lymph node, skin, and fat associated with the tibia bone, as well as 1 of 2 muscle specimens, 1 of 4 tendon specimens, and 1 of 2 bone marrow specimens. (
  • We identified West Nile Virus RNA in spleen/lymph node homogenate, skin, fat, muscle, tendon, and bone marrow samples obtained postmortem from a donor associated with transmission of West Nile Virus through solid organ transplantation. (
  • Possible problems with liver, spleen, and bone marrow. (
  • It is found in the particular India field system of the liver, spleen and bone marrow, and has a terminal half life of 7 to 12 hours. (
  • The spleen is a brown, flat, oval-shaped lymphatic organ that filters and stores blood to protect the body from infections and blood loss. (
  • The spleen is not a vital organ - its functions are useful but not essential for life. (
  • Because it is not a vital organ and is so soft, spongy, and vascular, damage to the spleen is almost always treated by its complete removal. (
  • The spleen is an important organ in the immune system. (
  • In fact, some people say that this is a well-known contradiction: the Stomach is a Yang organ but it suffers from Yin deficiency while the Spleen is a Yin organ but it suffers from Yang deficiency. (
  • In addition, the last half-month of each season is also a Spleen time regardless of the organ system, thus Spleen/Spleen now. (
  • The spleen is an organ of the hematological system and has a role in immune response, storage of red blood cells and hematopoiesis. (
  • The spleen is a wedge-shaped organ lying mainly in the left upper quadrant (left hypochondrium and partly in the epigastrium) and is protected by the left 9to 11 ribs. (
  • The spleen is a fist-sized organ located on the lower left side of the rib cage. (
  • The coprimary end points were the percent change in spleen volume and percent-predicted diffusing capacity of the lung for carbon monoxide (DL CO ). (
  • these herbs are primarily used for stagnation involving the spleen and stomach, constrained liver qi, and stagnant lung qi. (
  • The condition can result in an enlarged spleen or liver, difficulty breathing, lung infections, and unusual bruising or bleeding, among other symptoms. (
  • According to the release, FDA based its approval on results from two clinical trials (ASCEND and ASCEND-Ped), which demonstrated clinically relevant improvement in lung function (as measured by diffusing capacity of the lung for carbon monoxide) and platelet count as well as reduced liver and spleen volumes. (
  • Protected by our ribs, the spleen is located between the stomach and the diaphragm in the left hypochondriac region of the abdominal body cavity. (
  • Some individuals with a very enlarged spleen may complain of early satiety ( anorexia ) and gastric reflux symptoms because of the stomach displacement and pressure on the stomach as a result of the enlarged spleen. (
  • Doctor Wang Lun Ti (Ming dynasty) said that Stomach-Fire may injure Spleen-Yin. (
  • Dr Hong Guang Huai makes an important differentiation between Stomach-Yin and Spleen-Yin deficiency. (
  • He says that in Stomach-Yin deficiency there is a deficiency of fluids while in Spleen-Yin deficiency there is a deficiency of Ying and Blood. (
  • It is thought to enter the large intestine , spleen and stomach channels and exhibits acrid , bitter (ku) and cold (han) taste/temperature properties. (
  • For stomach and spleen qi deficiency with dampness that has potentially generated mild interior-heat - diarrhea, abdominal pain, poor appetite, epigastric pain. (
  • Portal hypertension is the increased blood pressure in the portal vein, which carries blood from the stomach, intestines and spleen to the liver. (
  • The functions of the spleen normally include clearance of invading organisms in the blood (bacteria) from the circulation, production of antibodies for the immune system, and removal of abnormal blood cells. (
  • Chasse Spleen is a perennial favourite in the Irish market and regularly produces robust wines withchunky dark fruit and, ethereal spicy notes. (
  • Abscess or cyst in the spleen. (
  • The mass was found to consist almost entirely a very large abscess on the spleen ( Figure ), which contained ≈5 L of pus. (
  • Recently, an abscess of the spleen caused by Salmonella enterica serovar Enteritidis has been reported as a complication of P . falciparum malaria ( 4 ) and, to our knowledge, is the only case in the literature definitely related to Plasmodium infection. (
  • 1990. Spleen, lymph nodes, and thymus. (
  • This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets. (
  • Aids kidneys, liver, spleen and intestines. (
  • the presence of two of the three following diagnostic criteria of the fatty liver disease: increased hepatic echogenicity compared to the spleen or the kidneys, blurring of liver vasculature and deep attenuation of the ultrasonographic signal. (
  • To diagnose mono, doctors do an exam to check for things like swollen tonsils and an enlarged liver or spleen, common signs of the infection. (
  • This paper reports on the clinical picture of a patient with fatal malignant melanoma and hepatic and spleen metastases. (
  • What Are the Spleen and Lymphatic System? (
  • The spleen is part of the lymphatic system , which is an extensive drainage network. (
  • White pulp regions of the spleen are made of lymphatic tissue containing macrophages, T lymphocytes, and B lymphocytes that destroy pathogens in the blood and produce antibodies. (
  • The spleen may enlarge during certain infections due to an increase in the number of white blood cells, captured pathogens and antibodies inside the spleen. (
  • The causes of splenomegaly vary widely and range from malignancy (cancers), infections, congestion (increased blood flow), infiltration of the spleen from other diseases, inflammatory conditions, and blood cell diseases. (
  • Spleen tyrosine kinase is considered an attractive drug target for the treatment of allergic and antibody mediated autoimmune diseases. (
  • Low molecular-weight peptides within spleen extract have also been shown to enhance the activity of natural killer cells for additional protection from potentially fatal diseases. (
  • The spleen plays an important role in your heath by helping your body fight infection. (
  • People who don't have a spleen or who have a spleen that doesn't work well are at risk for serious infection. (
  • These people, as well as those who had their spleen removed, are at risk for serious infection. (
  • If you had your spleen removed or are at risk for having a spleen that doesn't work well, talk with your doctor about these ways to help prevent getting an infection. (
  • When we study the pathology of the Internal Organs, for the Spleen, we generally emphasize Spleen-Qi deficiency and Spleen-Yang deficiency. (
  • All this is true, but in this article, I want to discuss the aetiology, pathology, diagnosis and treatment of Spleen-Yin deficiency. (
  • Although we nowadays emphasize Spleen-Yang deficiency, some of the old classics did often mention Spleen-Yin deficiency. (
  • Modern doctors interpret "Spleen-Qi not immersed" as Spleen-Yin deficiency. (
  • The Spleen may be deficient in Yang or Yin: in Spleen-Yin deficiency, there is a deficiency of Spleen-Blood and Empty Heat arises. (
  • The aetiology of Spleen-Yin deficiency is clearly dietary. (
  • However, besides the dietary causes, Spleen-Yin deficiency may also be caused by emotional stress related to worry and pensiveness and by excessive physical work that depletes the Spleen. (
  • Spleen-Yin includes Blood and Ying and for this reason Spleen-Yin deficiency may cause bleeding such as in the stools, vomit or under the skin. (
  • Please note the sign of dry lips as this is quite a key sign of Spleen-Yin deficiency. (
  • Chinese journals often include symptoms and signs of Empty Heat with Spleen-Yin deficiency and they say that this pattern causes the flaring up of the pathological Minister Fire. (
  • In chronic, long-standing cases, Spleen-Yin deficiency can indeed give rise to Empty Heat but, in very many cases, there is just Yin deficiency without Empty Heat (see Fig. 1 and Plates 1 and 2 above). (
  • Dr Mao Jiong divides the clinical manifestations of Spleen-Yin deficiency into three groups and this may help the diagnostic process. (
  • As mentioned above, dry lips is quite a key, distinctive sign of Spleen-Yin deficiency. (
  • Perhaps your acupuncturist mentioned something about spleen qi deficiency or weakness at your last appointment. (
  • Low appetite, apathy towards eating due to spleen qi deficiency. (
  • Changes in spleen structure, frequently encountered during malaria, may result either in a simple asymptomatic enlargement or in serious complications such as hematoma, rupture, or infarction ( 1 - 3 ). (
  • Spleen infarction is rarer than rupture and may go unnoticed. (
  • The report is the first recorded case of acute respiratory distress syndrome (ARDS) that required venovenous extracorporeal membrane oxygenation and was complicated by spontaneous spleen rupture. (
  • An enlarged spleen can rupture, causing pain and bleeding inside the belly, and needs emergency surgery. (
  • Hypersplenism (overactive spleen). (
  • in patients with hypersplenism, as much as 90% of the total platelet mass can be found in the spleen. (
  • The spleen helps the body fight germs and infections. (
  • After the spleen is removed, a person is more likely to develop infections. (
  • This is because the spleen is part of the body's immune system, helping fight infections. (
  • Spleen extract may be employed for conditions including hyposplenia (low spleen function), celiac disease, rheumatoid arthritis, and many infections, or for strengthening immune response. (
  • For example, hematologists (doctors who specialize in treating blood disorders ), oncologists ( cancer specialists), and gastroenterologists ( liver and digestive tract specialists) all commonly take care of patients who may have enlarged spleen as a response to another condition. (
  • In order to keep our digestive health strong and the spleen system strong, we need to feed it foods and drinks it can easily digest and utilize to transform and transport it to the relevant areas of our body. (
  • Looking to get your digestive health and spleen system functioning well again? (
  • IMSEAR at SEARO: Wandering spleen. (
  • Wandering spleen. (
  • Dutta K, Kar M, Mandal R. Wandering spleen. (
  • When Spleen Qi is deficient, the body not only doesn't build sufficient Blood or Qi but also doesn't supply them adequately to the organs or tissues. (
  • The Spleen rules the muscles, flesh and limbs, keeps the Organs in place and the Blood in vessels, opens to the mouth and manifests in the lips. (
  • One must nourish Yin, strengthen the Spleen, nourish Ying and "lift" fluids. (
  • Pure Spleen is an excellent source of spleen-specific nutrients to nourish the spleen and strengthen immune function. (
  • In many conditions, the spleen enlarges as a result of performing its normal physiologic function in response to another medical condition, for example, cirrhosis. (
  • Yun Hua is impaired not only when Spleen-Yang si deficient but also when Spleen-Yin is deficient, hence the lack of appetite. (
  • After being rushed to the hospital with a spleen laceration, Dahl decided to have his spleen removed three days later in order to return to the field this season. (
  • Blood clot (thrombosis) in the blood vessels of the spleen. (
  • Spongy inner tissue within the spleen contains many tiny blood vessels and hollow sinuses that store blood. (
  • The spleen can release its stored blood into circulation to replace blood lost during a traumatic injury. (
  • Many platelets are also stored with the blood in the spleen to help form blood clots to prevent further blood loss. (
  • The red pulp regions contain many net-like reticular fibers that filter worn-out red blood cells from the blood flowing through the spleen. (
  • These cells work to attack and destroy germs and remove them from the blood that passes through the spleen. (
  • The body also uses the spleen as a place to store blood and iron for future use. (
  • He began working on THE BLOOD-HUNGRY SPLEEN while teaching a sixth-grade life-science course. (
  • If your spleen was removed for a blood disorder or lymphoma, you may need more treatments. (
  • His disease progressed in early 2021, with increased spleen volume and progressive thrombocytopenia. (
  • This application protocol describes the flow cytometric analysis of macrophages after spleen dissociation from healthy C57BL/6 mice. (
  • It is mainly produced in the spleen and liver but can also occur elsewhere in the body by macrophages and renal tubular cells 2 . (
  • In intestinal schistosomiasis, there is progressive enlargement of the liver and spleen and intestinal damage. (
  • A tough connective tissue capsule surrounds the soft inner tissue of the spleen. (
  • Premium Pure Spleen is bovine-sourced from New Zealand-raised grass-fed cattle, free from pesticides, antibiotics, growth hormones, and bovine spongiform encephalopathy (BSE), then freeze-dried to retain freshness and potency. (
  • Tang Zong Hai, author of "Xue Zheng Lun" bemoaned the fact that, since Li Dong Yuan (author of "Pi Wei Lun"), doctors paid attention to Spleen-Yang but not Spleen-Yin. (
  • Around the vessels and sinuses of the spleen are regions of red pulp and white pulp with a marginal zone in between. (
  • Spleen, White pulp - Atrophy in a female F344/N rat from a subchronic study. (
  • Atrophy can affect the white pulp and/or red pulp compartments of the spleen. (
  • Splenomegaly is not always abnormal, and spleen size may not necessarily say much about its function. (
  • An enlarged spleen (splenomegaly) may be easier to palpate during a careful abdominal examination. (
  • With regard to Splenomegaly Related Score, a patient-reported outcome measurement that evaluates patient symptoms associated with an enlarged spleen, findings showed no meaningful difference between olipudase alfa and placebo (-8 point vs -9.3 points, respectively). (
  • tomography of the spleen: how to interpret the hypodense lesion. (
  • Immune cells were also skewed in the gut and spleen towards myeloid cells. (
  • The Spleen hates to be Damp, as this interferes with its ability to transform and transport food and fluids. (
  • Otherwise, many symptoms associated with an enlarged spleen are related to the underlying cause of the enlargement. (
  • The impact left the 31-year-old sprinter with facial wounds, road rash, and a ruptured spleen, although scans showed no signs of broken bones. (
  • As this occurs on all levels, Spleen Qi not only controls food and fluid metabolism but also cell respiration and other similar metabolic functions. (
  • I successfully treated all of these conditions with diet and herbs that focused mainly on strengthening the Spleen along with any other presenting patterns. (
  • When you're lying awake at night and your mind is racing, you can bet your Spleen is weak. (