Spironolactone. Medical search

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Drugs that bind to and block the activation of MINERALOCORTICOID RECEPTORS by MINERALOCORTICOIDS such as ALDOSTERONE.

A synthetic pregnadiene compound with anti-aldosterone activity.

A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)

A synthetic pregnadiene derivative with anti-aldosterone activity.

Cytoplasmic proteins that specifically bind MINERALOCORTICOIDS and mediate their cellular effects. The receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of DNA.

Agents that promote the excretion of urine through their effects on kidney function.

Pregnane derivatives containing two double bonds anywhere within the ring structures.

A synthetic mineralocorticoid with anti-inflammatory activity.

A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)

A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.

A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.

Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.

A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.

Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)

A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.

A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).

Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.

A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.

A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Therapy with two or more separate preparations given for a combined effect.

A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

Excision of one or both adrenal glands. (From Dorland, 28th ed)

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.

Absence of hair from areas where it is normally present.

A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.

Loss of scalp and body hair involving microscopically inflammatory patchy areas.

A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.

Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.

Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.

Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)

Techniques for measuring blood pressure.

A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. (1/759)

BACKGROUND: Steroid-induced gene regulation in the endocrine tissues and vascular wall is achieved through the interaction of specific receptor proteins and promoters of target genes. In addition to these delayed steroid actions, rapid effects of steroids have been reported in various tissues that were clearly incompatible with the classic theory of genomic steroid action. METHODS AND RESULTS: Because high doses of 17beta-estradiol have been shown to modulate intracellular cAMP levels in vascular smooth muscle cells, steroid-induced stimulation of adenylate cyclase stimulation and phosphorylation of cAMP response element binding protein was investigated in porcine coronary artery vascular smooth muscle cells. Aldosterone induces a approximately 1.5- to 2.5-fold increase in intracellular cAMP levels (EC50 approximately 0.01 to 0.1 nmol/L) within 1 minute, whereas 17beta-estradiol and hydrocortisone act only at supraphysiological concentrations (10 micromol/L). Aldosterone-induced changes in intracellular cAMP are calcium dependent; they are not blocked by inhibitors of mineralocorticoid receptors, transcription, or protein synthesis. In addition, aldosterone induces a time-dependent phosphorylation of cAMP response element binding protein with potential transcriptional importance. CONCLUSIONS: A nongenomic modulation of vascular smooth muscle cells by aldosterone is consistent with the data that aldosterone, not estrogen, is the physiological stimulus for cAMP. (+info)

Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. (2/759)

There is increasing evidence for important cardiovascular effects of aldosterone via classical mineralocorticoid receptors in the heart. Administration of aldosterone with excess salt produces both cardiac hypertrophy and interstitial cardiac fibrosis in rats, and concomitant administration of potassium canrenoate at a dose that only modestly lowers blood pressure completely blocks the cardiac effects of aldosterone. In the present study, we examined the effect on left ventricular hypertrophy of adding a low dose of the mineralocorticoid receptor antagonist spironolactone (25 mg/d) to an angiotensin-converting enzyme inhibitor (enalapril maleate) in patients with essential hypertension. Eighteen untreated patients with moderate to severe essential hypertension based on the WHO/ISH guidelines participated in this study. Subjects were treated with either an angiotensin-converting enzyme inhibitor alone (group I: 10 patients, 4 men and 6 women, mean age 56 +/- 18 yr) or an angiotensin-converting enzyme inhibitor plus spironolactone (group II: 8 patients, 3 men and 5 women, mean age 59 +/- 14 yr) for 9 mo. Left ventricular mass index, various echocardiographic variables, mean blood pressure, plasma renin activity, and plasma aldosterone concentration before treatment were similar in the two groups. Blood pressure of both groups decreased significantly and similarly after antihypertensive treatment (group I, 136 +/- 9/82 +/- 9 mmHg; group II, 133 +/- 9/85 +/- 10 mmHg). Left ventricular mass index also decreased significantly in both groups (group I, -10.2 +/- 7.1%; group II, -18.1 +/- 6.9%). The extent of reduction was significantly greater in the spironolactone group (group II) (p < 0.05 vs. group I). In group II patients, spironolactone did not cause any side effects during the observation period. We conclude that spironolactone may have beneficial effects on left ventricular hypertrophy in patients with essential hypertension who are receiving an angiotensin-converting enzyme inhibitor. (+info)

Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats. (3/759)

Brain mineralocorticoid receptors appear to contribute to mineralocorticoid hypertension and may be involved in blood pressure control in normotensive rats. We examined the effect of blockade of central mineralocorticoid receptors with the use of a selective antagonist (RU28318) on cardiovascular and renal function in conscious normotensive rats. The contribution of renal innervation was evaluated in rats with bilaterally denervated kidneys. Young adult, male Wistar rats were trained for systolic blood pressure measurement by a tail sphygmographic method and accustomed to metabolic cages for collection of urine. One week before experimentation, an intracerebroventricular cannula was implanted. Systolic blood pressure was diminished 30 minutes after an intracerebroventricular dose of 10 ng of RU28318. The effect was maximal at 8 hours and was still present after 24 hours. Blood pressure returned to the basal level by 48 hours. During the period 0 to 8 hours after intracerebroventricular injection, rats treated with the antagonist showed an increase in diuresis and urinary electrolyte excretion. No significant effect on plasma renin activity, measured 8 and 30 hours after administration of RU28318, was observed. In denervated rats, the decrease in systolic blood pressure after administration of RU28318 was reduced. The difference was statistically significant compared with controls at 2 hours but not at 8 hours, and blood pressure returned to the basal value by 24 hours. The increases in diuresis and urinary electrolyte excretion induced by RU28318 were abolished in denervated rats. These results show that brain mineralocorticoid receptors are involved in blood pressure regulation and kidney function homeostasis in conscious normotensive rats. The renal nerves appear to participate in the brain mineralocorticoid receptor control of blood pressure. (+info)

Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. (4/759)

1. We have recently shown that neurones in the rostral region of the medial vestibular nucleus (MVN) develop a sustained increase in their intrinsic excitability within 4 h of a lesion of the vestibular receptors of the ipsilateral inner ear. This increased excitability may be important in the rapid recovery of resting activity in these neurones during 'vestibular compensation', the behavioural recovery that follows unilateral vestibular deafferentation. In this study we investigated the role of the acute stress that normally accompanies the symptoms of unilateral labyrinthectomy (UL), and in particular the role of glucocorticoid receptors (GRs), in the development of the increase in excitability in the rostral MVN cells after UL in the rat. 2. The compensatory increase in intrinsic excitability (CIE) of MVN neurones failed to occur in animals that were labyrinthectomized under urethane anaesthesia and kept at a stable level of anaesthesia for either 4 or 6 h after UL, so that they did not experience the stress normally associated with the vestibular deafferentation syndrome. In these animals, 'mimicking' the stress response by administration of the synthetic GR agonist dexamethasone at the time of UL, restored and somewhat potentiated CIE in the MVN cells. Administration of dexamethasone in itself had no effect on the intrinsic excitability of MVN cells in sham-operated animals. 3. In animals that awoke after labyrinthectomy, and which therefore experienced the full range of oculomotor and postural symptoms of UL, there was a high level of Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus over 1.5-3 h post-UL, indicating a strong activation of the stress axis. 4. The GR antagonist RU38486 administered at the time of UL abolished CIE in the rostral MVN cells, and significantly delayed behavioural recovery as indicated by the persistence of circular walking. The mineralocorticoid receptor (MR) antagonist spironolactone administered at the time of UL had no effect. 5. Vestibular compensation thus involves a novel form of 'metaplasticity' in the adult brain, in which the increase in intrinsic excitability of rostral MVN cells and the initial behavioural recovery are dependent both on the vestibular deafferentation and on the activation of glucocorticoid receptors, during the acute behavioural stress response that follows UL. These findings help elucidate the beneficial effects of neuroactive steroids on vestibular plasticity in various species including man, while the lack of such an effect in the guinea-pig may be due to the significant differences in the physiology of the stress axis in that species. (+info)

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. (5/759)

BACKGROUND AND METHODS: Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663 patients who had severe heart failure and a left ventricular ejection fraction of no more than 35 percent and who were being treated with an angiotensin-converting-enzyme inhibitor, a loop diuretic, and in most cases digoxin. A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. The primary end point was death from all causes. RESULTS: The trial was discontinued early, after a mean follow-up period of 24 months, because an interim analysis determined that spironolactone was efficacious. There were 386 deaths in the placebo group (46 percent) and 284 in the spironolactone group (35 percent; relative risk of death, 0.70; 95 percent confidence interval, 0.60 to 0.82; P<0.001). This 30 percent reduction in the risk of death among patients in the spironolactone group was attributed to a lower risk of both death from progressive heart failure and sudden death from cardiac causes. The frequency of hospitalization for worsening heart failure was 35 percent lower in the spironolactone group than in the placebo group (relative risk of hospitalization, 0.65; 95 percent confidence interval, 0.54 to 0.77; P<0.001). In addition, patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients. CONCLUSIONS: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure. (+info)

Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms. (6/759)

BACKGROUND: In vascular smooth muscle cells (VSMCs), Na+/H+ exchange (NHE) plays an important role in intracellular pH (pHi) regulation. Recently, nongenomic effect of aldosterone (ALDO) on NHE activity has been suggested in VSMCs. However, the nongenomic and genomic effects of ALDO on NHE and the intracellular signaling mechanisms for these effects have not fully been determined in VSMCs. METHODS: The effects of short- (3 hr) and long- (24 hr) term exposure to ALDO on NHE activity were examined in cultured VSMCs from rat thoracic aortae by using single-cell pHi measurement with the pH-sensitive dye 2'7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. The NHE activity was calculated from the initial rate of Na+-dependent pHi recovery after acid load. RESULTS: The NHE activity significantly increased after short- and long-term exposure of VSMCs to ALDO (10(-6) M). The inhibitors of gene transcription (actinomycin D) and of protein synthesis (cycloheximide) had no effect on the short-term ALDO effect, but inhibited the long-term ALDO effect. The antagonists of the mineralocorticoid receptor (MR) (spironolactone) and of the glucocorticoid receptor (GR) (RU38486) caused no effect on the short-term ALDO effect, but inhibited the long-term ALDO effect. Two protein kinase C (PKC) inhibitors (staurosporine A and calphostin C) and PKC down-regulation (24 hr pre-exposure to phobol 12-myristate 13-acetate, PMA) inhibited both the short- and long-term ALDO effects. Exposure of VSMCs to PMA for 3 hours mimicked the short-term effect of ALDO on NHE activity. ALDO significantly increased PKC activity in VSMCs. The short-term ALDO effect was inhibited by disruptors of microtubule (colchicine) and of filamentous-actin (cytochalasin B). Long-term exposure of ALDO caused a threefold increase in NHE (NHE-1) mRNA levels. CONCLUSIONS: The short-term effect of ALDO on NHE activity is not mediated through either MR or GR, occurs independent of gene transcription and protein synthesis, and occurs through a mechanism involving the structural elements of cytoskeleton. The long-term effect of ALDO on NHE activity occurs through both MR and GR and requires gene transcription and protein synthesis. Both short- and long-term effects of ALDO are mediated through PKC activation. Therefore, ALDO activates NHE by nongenomic and genomic mechanisms in VSMCs. (+info)

Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia. (7/759)

AIM: To determine if the diuretic spironolactone cross reacts with 17alpha-hydroxyprogesterone (17OHP) in an enzyme linked immunosorbent assay (ELISA) kit used for the mass screening of congenital adrenal hyperplasia. METHODS: Concentrations of 17OHP on a blood filter paper disc were measured using an ELISA kit (kit C-7: ENZAPLATE N-17alpha -OHP-7; Chiron, Tokyo, Japan). The cross reactivity of spironolactone and its metabolites with 17OHP was determined. The concentrations of spironolactone and its metabolites in blood were measured using HPLC (high performance liquid chromatography). RESULTS: Spironolactone cross reacted with 17OHP using kit C-7 (0.01%), by increasing 17OHP concentration in a dose dependent manner. The blood concentration of spironolactone and its metabolites was nearly 900 ng/ml, high enough to show an additive effect on the 17OHP concentration. About 12% of the false positive cases screened using the kit were due to the administration of spironolactone. CONCLUSIONS: Spironolactone interferes with 17OHP concentrations, leading to false positive test results for CAH. (+info)

Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. (8/759)

We tested the ability of captopril treatment (50 mg/kg/day p.o.), initiated 2 weeks before stroke or up to 5 days after stroke, to alter the onset of stroke and death after stroke in Kyoto Wistar stroke-prone spontaneously hypertensive rats (SHRsp). The benefits of blood pressure and aldosterone suppression during captopril treatment were assessed. SHRsp developed a 100% mortality rate with intracerebral hemorrhage by 16 weeks of age. Captopril treatment, started 2 weeks before or at the initiation of stroke, suppressed plasma aldosterone and equally prevented mortality to a mean age of >27 weeks. Treatment started 5 days after stroke extended the mean lifespan to >23 weeks. The re-elevation of plasma aldosterone (via osmotic pumps to levels in untreated SHRsp) during captopril treatment, before stroke, allowed stroke to develop. The initiation of the latter manipulation in pre- or poststroke captopril-treated SHRsp at a latter age (23 weeks) didn't alter the lifespan of SHRsp (death occurred at about 28 weeks). The antistroke effects of captopril treatment occurred without an antihypertensive effect, weren't altered by enhancing hypertension during treatment (with dexamethasone), and couldn't be duplicated by antihypertensive treatment with hydralazine. Spironolactone treatment didn't duplicate the effects of captopril. The suppression of plasma aldosterone may retard the onset of stroke in SHRsp during captopril treatment but likely other factors prolong life in pre- and poststroke SHRsp receiving long-term captopril treatment. The observation that spironolactone treatment couldn't duplicate the effects of captopril suggests that aldosterone may facilitate stroke through nongenomic receptor mechanisms. (+info)

Overdiek HW, Merkus FW (1987). "The metabolism and biopharmaceutics of spironolactone in man". Rev Drug Metab Drug Interact. 5 ... Cashman JR, Peña S (1989). "Canrenone formation via general-base-catalyzed elimination of 7 alpha-(methylthio)spironolactone S- ... Abshagen, U.; Rennekamp, H.; Luszpinski, G. (1976). "Pharmacokinetics of spironolactone in man". Naunyn-Schmiedeberg's Archives ... Spironolactone. Analytical Profiles of Drug Substances and Excipients. 29. pp. 261-320. doi:10.1016/S1075-6280(02)29009-6. ISBN ...

https://en.wikipedia.org/wiki/7α-Thiomethylspironolactone_sulfoxide

Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have ... relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and spironolactone for the rat prostate AR is about 3.0 to ... Doggrell SA, Brown L (2001). "The spironolactone renaissance". Expert Opin Investig Drugs. 10 (5): 943-54. doi:10.1517/ ... Other important metabolites of spironolactone include 7α-thiospironolactone (7α-TS; SC-24813), 6β-hydroxy-7α- ...

https://en.wikipedia.org/wiki/7α-Thiomethylspironolactone

Spironolactone (SC-9420; Aldactone), another spirolactone, followed and had both good oral bioavailability and potency, and was ...

https://en.wikipedia.org/wiki/SC-8109

... and spironolactone (Aldactone). Pravastatin is cleared by the kidneys, giving it a distinct advantage over other statins when a ...

https://en.wikipedia.org/wiki/Pravastatin

Spironolactone is described as a relatively weak antiandrogen. It is widely used in the treatment of acne, excessive hair ... Spironolactone is an antiandrogen as a secondary and originally unintended action. It works as an antiandrogen mainly by acting ... Spironolactone has been found to decrease the bioavailability of high doses of oral estradiol. Although widely employed, the ... Spironolactone (Aldactone), which is relatively safe and inexpensive, is the most frequently used antiandrogen in the United ...

https://en.wikipedia.org/wiki/Feminizing_hormone_therapy

Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have ... relative to that of spironolactone. The affinity of 7α-TS, 7α-TMS, and spironolactone for the rat prostate AR is about 3.0 to ... A study assessed the interaction of spironolactone and 7α-TS with sex hormone-binding globulin and found that they had very low ... Gardiner P, Schrode K, Quinlan D, Martin BK, Boreham DR, Rogers MS, Stubbs K, Smith M, Karim A (1989). "Spironolactone ...

https://en.wikipedia.org/wiki/7α-Thiospironolactone

Spironolactone (SC-9420; Aldactone) followed and had both good oral bioavailability and potency, and was the first synthetic ... Similarly to other spirolactones like canrenone and spironolactone, SC-5233 has some antiandrogenic activity and antagonizes ...

https://en.wikipedia.org/wiki/SC-5233

The steroidal antiandrogen spironolactone is first synthesized 1960: Spironolactone is first introduced for medical use, as an ... spironolactone, bicalutamide, and ketoconazole. Spironolactone and bicalutamide require combination with an aromatase inhibitor ... Spironolactone has been marketed in Italy in the form of a topical cream under the brand name Spiroderm for the treatment of ... However, spironolactone was introduced in 1959, although its antiandrogen effects were not recognized or taken advantage of ...

https://en.wikipedia.org/wiki/Antiandrogen

Spironolactone, an aldosterone antagonist. This has two actions, firstly, as a potassium-sparing diuretic, although its ...

https://en.wikipedia.org/wiki/Pimobendan

SC-9420 for spironolactone). The spirolactones include the marketed drugs spironolactone (SC-9420; Aldactone), canrenone (SC- ... Spironolactone is a derivative of SC-5233 with a 7α-acetylthio group (that is, SC-5233 is 7α-desthioacetylspironolactone). 7α- ... spironolactone as an antiandrogen, and drospirenone as a progestin). The spirolactones were developed by G. D. Searle & Company ...

https://en.wikipedia.org/wiki/Spirolactone

... or decreased renal function that may occur with spironolactone treatment. In women, unlike CPA and spironolactone, bicalutamide ... Unlike spironolactone, bicalutamide has no antimineralocorticoid activity, and for this reason, has no risk of hyperkalemia ( ... As such, although bicalutamide has not been compared head-to-head to CPA or spironolactone in the treatment of androgen- ... However, some of them, namely CPA and spironolactone, are still commonly used in the management of certain androgen-dependent ...

https://en.wikipedia.org/wiki/Comparison_of_bicalutamide_with_other_antiandrogens

Diuretics: hydrochlorothiazide, spironolactone, chlortalidone. ACE inhibitors: captopril, enalapril. Other drugs: digoxin, ...

https://en.wikipedia.org/wiki/Eosinophilic_myocarditis

Greenblatt DJ, Koch-Weser J (July 1973). "Adverse reactions to spironolactone. A report from the Boston Collaborative Drug ... In contrast to the SAA spironolactone, bicalutamide does not have antimineralocorticoid effects, and hence is not associated ... In women, unlike CPA and spironolactone, bicalutamide does not produce menstrual irregularity or amenorrhea and does not ...

https://en.wikipedia.org/wiki/Bicalutamide

The hormonal IUD is inserted in a similar procedure to the nonhormonal copper IUD, and can only be inserted by a qualified medical practitioner.[39] Before insertion, a pelvic exam is performed to examine the shape and position of the uterus. It is also recommended that patients be tested for gonorrhea and chlamydia prior to insertion, as a current STI at the time of insertion can increase the risk of pelvic infection.[61] However, if a person has been previously screened and there is no evidence of infection on examination insertion of the IUD does not need to be delayed.[62] During the insertion, the vagina is held open with a speculum, the same device used during a pap smear.[39] A grasping instrument is used to steady the cervix, the length of the uterus is measured for proper insertion, and the IUD is placed using a narrow tube through the opening of the cervix into the uterus.[39] A short length of monofilament plastic/nylon string hangs down from the cervix into the vagina. The string ...

https://en.wikipedia.org/wiki/Hormonal_IUDs

... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...

https://en.wikipedia.org/wiki/Schedule_H

The combined hormonal contraceptive vaginal ring is self-administered once a month. Leaving the ring in for three weeks slowly releases hormones into the body, mainly vaginally administered estrogens and/or progestogens (a group of hormones including progesterone) - the same hormones used in birth control pills.[4] These hormones work mostly by stopping ovulation and thickening the cervical mucus, creating a barrier preventing sperm from fertilizing an egg.[4] They could theoretically affect implantation but no evidence shows that they do.[5] Worn continuously for three weeks followed by a week off, each vaginal ring provides anywhere from one month (NuvaRing) to one year (Annovera and Progering) of birth control. For continuous-use contraception, users can also choose to wear the vaginal ring for the full four week cycle. This manner of contraception will eliminate monthly periods.[6] Throughout the additional week, the serum hormone levels will remain in the contraceptive range.[7] When ...

https://en.wikipedia.org/wiki/Vaginal_ring

... (also ethinyl estradiol/levonorgestrel) is a combined birth control pill made up of ethinylestradiol, an estrogen and levonorgestrel a progestin.[2] It is used for birth control, symptoms of menstruation, endometriosis, and as emergency contraception.[1][2] It is taken by mouth.[1] Side effects can include nausea, headache, blood clots, breast pain, depression, and liver problems.[2] Use is not recommended during pregnancy, the initial three weeks after childbirth, and in those at high risk of blood clots.[2] However, it may be started immediately after a miscarriage or abortion.[3] Smoking while using combined birth control pills is not recommended.[1] It works by stopping ovulation, making the mucus at the opening to the cervix thick, and making the uterus not suitable for implantation.[1] Ethinylestradiol/levonorgestrel has been approved for medical use in the United States at least since 1982.[1] It is on the World Health Organization's List of Essential ...

https://en.wikipedia.org/wiki/Ethinylestradiol/levonorgestrel

Dioscorides, ca. 40 A.D., described the contraceptive property of hemp seeds (Cannabis sativa) and rue (Ruta graveolens) in De Materia Medica, a text widely used into medieval times.[18] One test in rats (20 milligrams of the 80% ethanol extract) found that these reduced sperm count by more than half.[19] In medieval Persia (and in other traditions as cited) these herbs were used for male contraception, as well as Gossypium herbaceum (Malvaceae),[20] Cyperus longus (Cyperaceae), Vitex pseudonegundo (Verbenaceae), Chenopodium ambrosioides (Chenopodiaceae),[21][22] Aristolochia indica (Aristolochiaceae),[23] Punica granatum (Punicaceae),[24] and Sarcostemma acidum (Asclepiadaceae).[25] However, the compound isolated from Gossypium, as well as other cotton seeds and okra (gossypol) has been abandoned for contraceptive use because it was found to cause permanent infertility in ten to twenty percent of users.[26] In Indian traditional medicine, uses of the neem tree were described in Ayurvedic ...

https://en.wikipedia.org/wiki/Male_contraceptive

Irregular bleeding and spotting: Many women will experience some type of irregular, unpredictable, prolonged, frequent, or infrequent bleeding when using Nexplanon or Implanon.[18] Some women also experience amenorrhea. For some women, prolonged bleeding will decline after the first three months of use. However, other women may experience this bleeding pattern through all three years of use. While these patterns are not dangerous, they are the most common reason that women give for discontinuing the use of the implant. After removal, bleeding patterns return to previous patterns in most women.[13][14][15][16]. Insertion complications: Some minor side effects such as bruising, skin irritation, or pain around the insertion site are common.[13] However, there are some rare complications that can occur, such as infection or expulsion.[13][19] In some cases, a serious complication occurs when the provider fails to insert, and the rod is left in the inserter. An Australian study reported 84 ...

https://en.wikipedia.org/wiki/Nexplanon

All contain an estrogen, ethinylestradiol or mestranol,[1][2] in varying amounts, and one of a number of different progestogens. (Regarding the estrogen, the inactive 3-methyl ether of ethinylestradiol, which must be metabolized by the liver into the active ethinylestradiol; 50 µg of mestranol is equivalent to only 35 µg of ethinylestradiol and should not be used when high-dose [50 µg ethinylestradiol] estrogen pills are needed; mestranol was the estrogen used in the first oral contraceptive, Enovid). They are usually taken for 21 days with then a seven-day gap during which a withdrawal bleed (often, but incorrectly, referred to as a menstrual period) occurs. These differ in the amount of estrogen given, and whether they are monophasic (the same dose of estrogen and progestogen during each of the 21 days) or multiphasic (varying doses). The introduction of extended-cycle monophasic pills (i.e. Seasonale) has shown that the withdrawal bleeding intervals can be decreased. ...

https://en.wikipedia.org/wiki/Oral_contraceptive_formulations

The first CIC to be studied was estradiol valerate/hydroxyprogesterone caproate (EV/OHPC) in 1963, and the second CIC to be studied was estradiol enantate/algestone acetophenide (E2-EN/DHPA) in 1964.[18][17] In 1967, E2-EN/DHPA was in the late stages of clinical development.[25][18] By 1969, the medication was available for medical use under the brand name Perlutal.[26] Within a few years, it was marketed under other brand names such as Topasel and Ova-Repos as well.[27][28][29][30] In addition, several other CICs had been introduced for medical use by 1972.[30] By 1976, two major CICs were in use: E2-EN/DHPA (brand names Perlutan, Topasel) in Spain and Latin America, and EV/OHPC (brand name Injectable No. 1) in China.[31] These CICs have been described as first-generation CICs.[31] Two second-generation CICs, estradiol cypionate/medroxyprogesterone acetate (EC/MPA; brand names Cyclofem and later Lunelle) and estradiol valerate/norethisterone enantate (EV/NETE; brand name Mesigyna), were ...

https://en.wikipedia.org/wiki/Combined_injectable_contraceptive

Some American legislators have unsuccessfully attempted to provide financial incentives to women on welfare who agree to use Norplant. For example, in Kansas, Republican Kerry Patrick introduced legislation that would grant welfare recipients a one-time payment of $500 to use Norplant, followed by a $50 bonus each year the implants remained in place."[30] Some judges have offered Norplant implants as a voluntary alternative to jail time for certain women convicted of child abuse or drug abuse during pregnancy. Two days after the 1990 FDA approval of Norplant, an editorial in The Philadelphia Inquirer suggested reducing the size of the black underclass by offering welfare mothers increased benefits if they agreed to use Norplant.[30][31] Eleven days later the Inquirer apologized for their "misguided and wrongheaded" editorial and for their suggestion of offering incentives for Norplant use.[30][32] Critics such as the ACLU argued that such uses are coercive and discriminatory, and compared such ...

https://en.wikipedia.org/wiki/Norplant

Irregular bleeding and spotting: Many women will experience some type of irregular, unpredictable, prolonged, frequent, or infrequent bleeding.[23] Some women also experience amenorrhea. For some women, prolonged bleeding will decline after the first three months of use. However, other women may experience this bleeding pattern through all five years of use. While these patterns are not dangerous, they are the most common reason that women give for discontinuing the use of the implant. After removal, bleeding patterns return to previous patterns in most women.[19][20][21] Insertion complications: Some minor side effects such as bruising, skin irritation, or pain around the insertion site are common.[19] However, there are some rare complications that can occur, such as infection or expulsion.[19][24] In some cases, a serious complication occurs when the provider fails to insert, and the rod is left in the inserter. An Australian study reported 84 pregnancies as a result of such failure.[22] ...

https://en.wikipedia.org/wiki/Etonogestrel_birth_control_implant

In addition, spironolactone, a steroidal antimineralocorticoid that was introduced for medical use in 1959, was discovered to ... Ober KP, Hennessy JF (November 1978). "Spironolactone therapy for hirsutism in a hyperandrogenic woman". Ann. Intern. Med. 89 ( ... "Anti-androgenic activity of spironolactone". Steroids. 14 (4): 449-50. doi:10.1016/S0039-128X(69)80007-3. PMID 5344274. ...

https://en.wikipedia.org/wiki/Benorterone

Other medications known to cause gynecomastia include methadone; aldosterone antagonists (spironolactone and eplerenone); HIV ... and spironolactone. Medications that are probably associated with gynecomastia include calcium channel blockers such as ...

https://en.wikipedia.org/wiki/Gynecomastia

Like spironolactone, it is typically only used by women. Ketoconazole may help in women.[failed verification] Hair ... There is tentative support for spironolactone in women. Due to its feminising side effects and risk of infertility it is not ... Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side ... Rathnayake, D.; Sinclair, R. (2010). "Use of spironolactone in dermatology". Skinmed. 8 (6): 328-332, quiz 332. PMID 21413648. ...

https://en.wikipedia.org/wiki/Management_of_hair_loss

Important antimineralocorticoids are spironolactone and eplerenone. List of corticosteroids Baker ME, Katsu Y (July 2020). " ...

https://en.wikipedia.org/wiki/Mineralocorticoid

Spironolactone is an effective treatment for acne in adult women. Unlike combined birth control pills, it is not approved by ... Spironolactone is an aldosterone antagonist and is a useful acne treatment due to its ability to additionally block the ... The effectiveness of spironolactone for acne appears to be dose-dependent. High-dose cyproterone acetate alone reportedly ... Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. ...

https://en.wikipedia.org/wiki/Acne

Spironolactone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Only take the spironolactone product prescribed by your doctor and do not switch to a different spironolactone product unless ... Continue to take spironolactone even if you feel well. Do not stop taking spironolactone without talking to your doctor. ... Before taking spironolactone,. *tell your doctor and pharmacist if you are allergic to spironolactone; any other medications; ...

https://medlineplus.gov/druginfo/meds/a682627.html

Spironolactone, a diuretic, is also a weak inhibitor of the androgen receptor and a weak inhibitor of testosterone synthesis. ... Drugs such as spironolactone act as antagonists of aldosterone and compete with it for its site of action in the distal tubule ... Spironolactone, a diuretic, is also a weak inhibitor of the androgen receptor and a weak inhibitor of testosterone synthesis. ... As with most antagonists, spironolactone has no direct action of its own but simply prevents the action of the hormone, thereby ...

https://www.britannica.com/science/spironolactone

... spironolactone which is a type of medicine called a potassium-sparing diuretic and furosemide is a type of medicine called a ... Lasilactone (spironolactone, furosemide). Lasilactone capsules contain two active ingredients, spironolactone which is a type ... Spironolactone works by blocking the actions of a hormone in the body called aldosterone. This hormone is produced by glands ... Spironolactone may increase the level of potassium in your blood. If this medicine is taken with other medicines that can ...

https://www.netdoctor.co.uk/medicines/heart-blood/a6990/lasilactone-spironolactone-furosemide/

... Used for congestive heart failure that was supposed to save lives, Spironolactone also caused dozens of deaths ... I was taking spironolactone for about a year to treat acne. I was diagnosed at 43 with breast cancer. I do not have a family ... MY DOCTOR PERSCRIBED SPIRONOLACTONE TO ME BUT HE DIDNT SAY WHAT FOR. NOW I AM HAVING SEVERE HOT FLASHES BECAUSE OF TH DRG ... I was on Spironolactone for about 10-12 years for severe acne and the side effects were tolerable up until almost 2 years ago ...

https://www.lawyersandsettlements.com/lawsuit/spironolactone.html

Spironolactone and Hydrochlorothiazide: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking spironolactone and hydrochlorothiazide,. *tell your doctor and pharmacist if you are allergic to spironolactone, ... Continue to take spironolactone and hydrochlorothiazide even if you feel well. Do not stop taking spironolactone and ... Take spironolactone and hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than ...

https://medlineplus.gov/druginfo/meds/a601111.html

Spironolactone-induced gynecomastia. Florim Cuculi, Alex Suter and Paul Erne. CMAJ February 27, 2007 176 (5) 620-620-a; DOI: ... Spironolactone is a well-known cause of gynecomastia and may act by displacing androgen from the androgen receptor and sexual- ... Pathophysiology of spironolactone-induced gynecomastia. Ann Intern Med 1977;87:398-403. ... His medications included phenprocoumon, enalapril, nebivolol, spironolactone (25 mg once a day), torasemide, digoxin, ...

https://www.cmaj.ca/content/176/5/620.2.full

Low-dose spironolactone is generally very well tolerated. Even higher doses of spironolactone, such as 100 mg/day, are well ... Spironolactone may be more effective than birth control pills in the treatment of acne, and the combination of spironolactone ... Spironolactone is also used to treat Bartters syndrome due to its ability to raise potassium levels. Spironolactone has ... Also, spironolactone is immunosuppressive in the treatment of sarcoidosis. Most of the side effects of spironolactone are dose- ...

https://en.wikipedia.org/wiki/Spironolactone

... spironolactone) is a prescription diuretic used to remove the excess fluid caused by congestive heart failure, cirrhosis of the ... Aldactone (spironolactone) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive ... How should I keep spironolactone stored?. Aldactone should be stored at room temperature, below 25 C (77 F). ... What preparations of spironolactone are available?. Tablets: 25, 50, and 100 mg ...

https://www.medicinenet.com/spironolactone/article.htm

Spironolactone prophylaxis in mountain sickness.. Br Med J 1980; 280 doi: https://doi.org/10.1136/bmj.280.6229.1453 (Published ...

http://www.bmj.com/content/280/6229/1453.1

Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see Precautions). Spironolactone should be ... Spironolactone may cause mild acidosis.. Gynecomastia may develop in association with the use of spironolactone; physicians ... Spironolactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7α- ... Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b926d89c-2759-4dba-8895-533f9c8ca5e2

In Randomized Spironolactone Evaluation Study, patients with heart failure treated with a mean dose of 26 mg of spironolactone ... The Randomized Spironolactone Evaluation Study was a placebo controlled, double-blind study of the effect of spironolactone on ... Spironolactone tablets, USP contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7α- ... Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=99bbc053-0e41-4b4d-979a-db610908f2de

Prescriber Checkup » SPIRONOLACTONE SPIRONOLACTONE. Aldactone (spironolactone) is a potassium-sparing diuretic that blocks ...

https://projects.propublica.org/checkup/drugs/2044

... spironolactone) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive heart failure, ... Aldactone (spironolactone) Side Effects, Interactions, and Warnings. *What is Aldactone (spironolactone)?. *Important side ... Important side effects of Aldactone (spironolactone). *Aldactone (spironolactone) side effects list for healthcare ... Aldactone (spironolactone) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure ...

https://www.medicinenet.com/aldactone_spironolactone_side_effects_interactions/side-effects.htm

Epiduo rated 7.4/10 vs Spironolactone rated 7.6/10 in overall patient satisfaction. ... Compare Epiduo vs Spironolactone head-to-head for uses, ratings, cost, side effects, interactions and more. ... For Acne Im 42 and began taking spironolactone and using Differin for adult acne about a year ago. It took almost 8 months to ... Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat ...

https://www.drugs.com/compare/epiduo-vs-spironolactone

Spironolactone does not inhibit 5α-reductase. [...] The progestational activity of spironolactone is variable. The drug ... In accordance, replacement of spironolactone with canrenone in male patients has been found to reverse spironolactone-induced ... Keleştimur F, Everest H, Unlühizarci K, Bayram F, Sahin Y (March 2004). "A comparison between spironolactone and spironolactone ... Another study that directly compared the affinities of spironolactone and canrenone reported that spironolactone had 5-fold ...

https://en.wikipedia.org/wiki/Pharmacodynamics_of_spironolactone

Im 26 and a type1 diabetic, I have been taking Spironolactone for its anti-androg... ... Spironolactone or Finasteride?. This question is not really about hair loss even thought the Doc who is a Endocrinologist is ... Or are there better alternatives? Or should I continue on the 200mg Spironolactone and see if the symptoms go away? Thanks for ... Or are there better alternatives? Or should I continue on the 200mg Spironolactone and see if the symptoms go away? Thanks for ...

http://www.medhelp.org/posts/Hair-Loss-Alopecia/Spironolactone-or-Finasteride/show/1630062

A Moderate Drug Interaction exists between prednisone and spironolactone. View detailed information regarding this drug ... PredniSONE may reduce the effects of spironolactone in lowering blood pressure. The interaction is most likely to occur when ...

https://www.drugs.com/drug-interactions/prednisone-with-spironolactone-1936-0-2105-0.html

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. You may take this medicine with or without food, but it should be taken the same way (with or without food) each day. Shake the oral liquid well before each use. Measure it with a marked measuring spoon, oral syringe, or medicine cup. ...

https://www.mayoclinic.org/drugs-supplements/spironolactone-oral-route/proper-use/drg-20071534

... have removed specific mention of spironolactone from the recommendations. This may possibly reflect that spironolactone in the ... 4 We compared spironolactone with bendroflumethiazide in a randomized controlled study. Only spironolactone reduced arterial ... As spironolactone is not licensed in the UK, was there a difference between the prevalence of its use in the "Anglo" and ... Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertension. 2007; 49: 839-845. ...

http://hyper.ahajournals.org/content/50/3/e57

Learn about spironolactone and hydrochlorothiazide side effects, how to take spironolactone and... ... Before taking spironolactone and hydrochlorothiazide,. *tell your doctor and pharmacist if you are allergic to spironolactone, ... Continue to take spironolactone and hydrochlorothiazide even if you feel well. Do not stop taking spironolactone and ... Spironolactone and hydrochlorothiazide may cause side effects. Tell your doctor if any of these symptoms are severe or do not ...

http://www.lifescript.com/health/centers/hypertension/drugs/spironolactone_and_hydrochlorothiazide.aspx

Find treatment reviews for Spironolactone from other patients. Learn from their experiences about effectiveness, side effects ...

https://www.patientslikeme.com/treatment/spironolactone?brand=f

Since november I have been taking 100mg once a day of spironolactone used as off label acne medicine... Been reading it may be ... Since november I have been taking 100mg once a day of spironolactone used as off label acne medicine... Been reading it may be ...

https://community.babycenter.com/post/a41223073/spironolactone_pregnancy

WebMD provides information about interactions between Spironolactone-Hydrochlorothiazide Oral and potassium-sparing-diuretics- ... Drugs & MedicationsSPIRONOLACTONE-HCTZ. Drospirenone/Potassium Sparing Diuretics Interactions. This information is generalized ...

https://www.webmd.com/drugs/2/drug-3043/spironolactone-hydrochlorothiazide-oral/details/list-interaction-details/dmid-1582/dmtitle-potassium-sparing-diuretics-drospirenone/intrtype-drug

Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium, certain diuretics (such as amiloride, triamterene (Dyazide®, Dyrenium®, Maxzide®, Midamor®, Moduretic®), or other products containing spironolactone (Aldactone®). Check with your doctor immediately if blurred vision, difficulty reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor to check your eyes. This medicine may cause dizziness, drowsiness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent ...

https://www.mayoclinic.org/drugs-supplements/spironolactone-and-hydrochlorothiazide-oral-route/precautions/drg-20071484

... spironolactone of varying dosages, or spironolactone and steroids versus steroids alone when used to reduce hair growth and ... Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. *Brown J ... Authors conclusions: From the studies included in this review, there is some evidence to show that spironolactone is an ... Brown, J., Farquhar, C., Lee, O., Toomath, R., & Jepson, R. G. (2009). Spironolactone versus placebo or in combination with ...

https://www.mendeley.com/catalogue/99b2b7c5-5b74-3e01-bba8-87ff6cbf27b6/

Spironolactone) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ... relative to spironolactone were 1.10, 1.28, and 0.32, respectively. Relative to spironolactone, their binding affinities to the ... Changes in NYHA class were more favorable with spironolactone: In the spironolactone group, NYHA class at the end of the study ... Spironolactone. 1.30. 80 ng/mL at 2.6 hr. Approximately 1.4 hr (0.5) (β half-life). ...

https://www.rxlist.com/aldactone-drug.htm

... Systematic (IUPAC) name 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone Identifiers CAS ... Studies of spironolactone and the related compound potassium canrenoate (which, like spironolactone, metabolizes to canrenone) ... Spironolactone (marketed under the trade names Aldactone, Novo-Spiroton, Spiractin, Spirotone, Verospiron or Berlactone) is a ... On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. About one person in one ...

https://www.bionity.com/en/encyclopedia/Spironolactone.html

4. Spironolactone Spironolactone Top results for spironolactone - Trip Database or use your Google+ account Turning Research ... Spironolactone for heart failure with preserved ejection fraction. Full Text available with Trip Pro. Spironolactone for heart ... Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia Spironolactone and ... Gamechanger? Is Spironolactone the Magic Bullet for Resistant Hypertension? Gamechanger? Is Spironolactone the Magic Bullet for ...

https://www.tripdatabase.com/top/spironolactone

Find the most comprehensive real-world treatment information on Spironolactone-Hydrochlorothiazide at PatientsLikeMe. 14 ... bipolar I disorder or mild depression currently take Spironolactone-Hydrochlorothiazide. ...

https://www.patientslikeme.com/treatment/spironolactone-hydrochlorothiazide?sort=most-recent

Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your ... HCTZ-Spironolactone 25 mg-25 mg-GRE. slide 3 of 5, HCTZ-Spironolactone 25 mg-25 mg-GRE, ... HCTZ-Spironolactone 25 mg-25 mg-MYL. slide 4 of 5, HCTZ-Spironolactone 25 mg-25 mg-MYL, ... hydrochlorothiazide and spironolactone. Skip to the navigation Pronunciation: HYE dro KLOR oh THY a zide and spir ON oh LAK ...

https://www.cigna.com/healthwellness/hw/medications/hydrochlorothiazide-and-spironolactone-d03247a1

of a quite different type, spironolactone (Aldactone A), is used as an antagonist to the action of aldosterone in certain cases of hypertension. (britannica.com)
Aldactone (spironolactone) is classified as a potassium-sparing diuretic. (medicinenet.com)
Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body. (propublica.org)
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. (wikipedia.org)
What is Aldactone (spironolactone)? (medicinenet.com)
Aldactone ( spironolactone ) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure , cirrhosis of the liver , and kidney disease . (medicinenet.com)
Spironolactone (marketed under the trade names Aldactone , Novo-Spiroton , Spiractin , Spirotone , Verospiron or Berlactone ) is a diuretic and is used as an antiandrogen . (bionity.com)
Spironolactone was shown to have a significant mortality and morbidity benefit in the Randomized Aldactone Evaluation Study (RALES), which studied people with severe congestive heart failure (New York Heart Association functional class III or IV). (bionity.com)
Generic Aldactone (Spironolactone) is a drug used for blood pressure lowering as well as swelling reduction in numerous conditions including congestive heart failure, liver cirrhosis, hypokalemia, and others. (rxshop.md)
Generic Aldactone (Spironolactone) is a medication used for a variety of heart, kidney, and liver-related conditions in which fluid build-up and increased blood pressure occur. (rxshop.md)
How does Aldactone (Spironolactone) act? (rxshop.md)
How to use Generic Aldactone (Spironolactone)? (rxshop.md)
Spironolactone is the generic version of the brand name drug Aldactone. (sharecare.com)
Spironolactone (Aldactone) is a potassium-sparing diuretic that was approved many years ago. (aafp.org)
Based on earlier work suggesting a benefit of therapy, 2 the Randomized Aldactone Evaluation Study (RALES) was undertaken to evaluate the role of spironolactone when used in addition to standard therapy for CHF. (aafp.org)
Is aldactone (spironolactone) dangerous if I were to become pregnant while on it. (healthtap.com)
We evaluated the body among participants in the Time-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm who received spironolactone aldactone 75 mg spironolactone as a aldactone 75 mg spironolactone antihypertensive agent for allergic blood pressure and who had received BP measurements before and during spironolactone tell. (thedomains.com)
Because Aldactone 75 mg spironolactone lowers blood pressure, Dr Kluk has found that some patients feel light-headed when they first start treatment. (thedomains.com)
In the dose range of 25 mg to mg, aldactone 75 mg spironolactone worsen glucose tolerance and exert detrimental effects on the lipid profile. (thedomains.com)
During treatment, and truly aldactone 75 mg spironolactone that new agents will be employed that may reverse many of the features and potential complications of this syndrome and offer a happier and more productive life to all of you! (thedomains.com)
Aldactone spironolactone is a marketing-sparing diuretic water pill that prevents your rate from absorbing too much salt and adolescents aldactone 75 mg spironolactone potassium levels from getting too low. (thedomains.com)
Aldactone is available to treat heart aldactone 75 mg spironolactone, high risk pressure hypertension, or hypokalemia low blood levels in the advice. (thedomains.com)
Generic drug Spironolactone is considered just as safe and effective as its brand-name equivalents such as Aldactone and Spiractin. (internationaldrugmart.com)
Did you know that buying the generic drug Spironolactone from IDM is much cheaper than buying the Aldactone or Spiractin brand drug? (internationaldrugmart.com)

Spironolactone , a diuretic, is also a weak inhibitor of the androgen receptor and a weak inhibitor of testosterone synthesis. (britannica.com)
Lasilactone capsules contain two active ingredients, spironolactone which is a type of medicine called a potassium-sparing diuretic and furosemide is a type of medicine called a loop diuretic. (netdoctor.co.uk)
NSAIDs: May reduce the diuretic, natriuretic and antihypertensive effect of spironolactone ( 7.3 ). (nih.gov)
On its own, spironolactone is only a weak diuretic because it primarily targets the distal nephron (collecting tubule), where only small amounts of sodium are reabsorbed, but it can be combined with other diuretics to increase efficacy. (wikipedia.org)
The classification of spironolactone as a "potassium-sparing diuretic" has been described as obsolete. (wikipedia.org)
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. (drugs.com)
Why twice as many of those receiving atenolol-diuretic with potassium regimen compared with amlodipine-perindopril regimen received spironolactone is not explained. (ahajournals.org)
On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. (bionity.com)
Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. (cigna.com)
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. (cancer.gov)
Spironolactone is a steroidal potassium-sparing diuretic used in the treatment of oedema, hypertension and hyperaldosteronism. (inchem.org)
This study is, by far, the most scientifically rigorous evaluation of spironolactone as add-on therapy having been performed as a double-blind, randomized, crossover evaluation of spironolactone 25-50 mg, bisoprolol 5-10 mg, doxazosin 4-8 mg, and placebo in patients uncontrolled on a standardized three-drug regimen of an ACEi or ARB, calcium channel blocker, and a diuretic. (lww.com)
Spironolactone, a diuretic, helps the kidneys better process liquid waste, which then reduces the amount of water your body retains. (sharecare.com)
Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. (bioportfolio.com)
Spironolactone counteracts secondary aldosteronism induced by the volume depletion and associated sodium loss caused by active diuretic therapy. (bioportfolio.com)
One of the diuretics, spironolactone, is called a potassium-sparing diuretic and helps the body to retain potassium. (medbroadcast.com)
Spironolactone is a diuretic designed to help eliminate excess fluid in pets. (lambertvetsupply.com)
This causes spironolactone to act as a mild diuretic. (mindandmuscle.net)
Spironolactone is a gentler diuretic that gets to the root cause of much of the water retention brought on by steroid use. (mindandmuscle.net)
The familiar diuretic spironolactone has taken on new life as a treatment for left-sided congestive heart failure. (aafp.org)
Spironolactone is a pottassium sparing diuretic . (healthtap.com)
Spironolactone is a weak diuretic and is used because it does not require pottassium supplementation unlike other diueretics. (healthtap.com)
Spironolactone is a diuretic and can be used to get rid of the body's extra fluid. (healthtap.com)
FARMVILLE, N.C. , Aug. 7, 2017 /PRNewswire/ -- CMP Pharma today announced that the US Food and Drug Administration (FDA) has granted final approval of the company's New Drug Application (NDA) for CaroSpir (Spironolactone Oral Suspension, 25 mg/5mL) , the first and only FDA-approved oral liquid dosage form of the potassium-sparing diuretic spironolactone. (medindia.net)
Pharmacokinetic plasma curves of altizide (ALT), spironolactone (SPI) and two of the main metabolites of spironolactone, 7 alpha-thiomethyl-spirolactone (7TM) and canrenone (CAN) have been established in 12 healthy human volunteers (6 men and 6 women) after unique oral administration of 1 or 2 tablets of a combination of the two diuretic compounds: altizide (15 mg per tablet) and spironolactone (25 mg per tablets). (sigmaaldrich.com)

Diuretics such as spironolactone and furosemide can therefore be used to lower high blood pressure. (netdoctor.co.uk)
tell your doctor and pharmacist if you are allergic to spironolactone, hydrochlorothiazide, thiazide diuretics (''water pills''), sulfa-based medications, penicillin, other medications, or any of the ingredients in spironolactone and hydrochlorothiazide tablets. (medlineplus.gov)
Spironolactone belongs to a class of medications known as potassium-sparing diuretics. (wikipedia.org)
While loop diuretics remain first-line for most people with heart failure, spironolactone has shown to reduce both morbidity and mortality in numerous studies and remains an important agent for treating fluid retention, edema, and symptoms of heart failure. (wikipedia.org)
In this Anglo-Scandinavian Cardiac Outcomes Trial subgroup it appears that less than half the subjects defined as being resistant had been exposed to diuretics and their response to spironolactone was not different. (ahajournals.org)
Unlike other diuretics, spironolactone does not cause potassium loss. (patientassistance.com)
Spironolactone and other diuretics can treat water retention from liver cirrhosis by flushing excess fluid from the body in the form of urine. (sharecare.com)
Spironolactone and hydrochlorothiazide both belong to the family of medications called diuretics (water pills). (medbroadcast.com)

I was prescribed Spironolactone for hypertension after taking for one month i had to stop because i developed Gynecomastia. (lawyersandsettlements.com)
Spironolactone is indicated for the treatment of hypertension, to lower blood pressure. (nih.gov)
Spironolactone is used primarily to treat heart failure, edematous conditions such as nephrotic syndrome or ascites in people with liver disease, essential hypertension, low blood levels of potassium, secondary hyperaldosteronism (such as occurs with liver cirrhosis), and Conn's syndrome (primary hyperaldosteronism). (wikipedia.org)
The recent article by Chapman 1 and the accompanying editorial by Goodfriend 2 provide an evidence base for an increased use of spironolactone in patients with resistant hypertension. (ahajournals.org)
We 3 have previously shown, albeit in a much smaller study, a significantly greater BP reduction to spironolactone 50 mg daily in resistant hypertension in individuals with potassium of under as opposed to over 4 mmol/L. (ahajournals.org)
Chapman et al remark that they provide unique support for the British Hypertension Society 2004 recommendations regarding the use of spironolactone as a fourth line agent. (ahajournals.org)
They should be aware that the current British Hypertension Society/NICE Guidelines, 5 issued June 2006, have removed specific mention of spironolactone from the recommendations. (ahajournals.org)
This may possibly reflect that spironolactone in the United Kingdom, unlike many other countries, is not licensed for the treatment of hypertension. (ahajournals.org)
Perhaps this study will help reinstate spironolactone to its rightful place in the management of hypertension. (ahajournals.org)
Effect of spironolactone on blood pressure in subjects with resistant hypertension. (ahajournals.org)
Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial. (tripdatabase.com)
Spironolactone is effective at reducing blood pressure in patients with uncontrolled resistant hypertension. (tripdatabase.com)
Spironolactone is effective for treating resistant hypertension Spironolactone is effective for treating resistant hypertension Discover Portal Discover Portal Spironolactone is effective for treating resistant hypertension Published on 1 December 2015 doi: This trial investigated which drug is best added to high blood pressure (hypertension) treatment if blood pressure has not come down to normal levels after taking three blood pressure lowering drugs. (tripdatabase.com)
A large number of studies have demonstrated the seemingly preferential benefit of spironolactone to reduce blood pressure (BP) when used as a fourth or fifth medication in patients with uncontrolled resistant hypertension. (lww.com)
The recently published findings of the PATHWAY-2 study firmly establish spironolactone as the most effective fourth drug in patients with uncontrolled resistant hypertension [3] . (lww.com)
Combined, the findings of the above studies, as well as many others, clearly establish spironolactone as the best fourth antihypertensive agent for treatment of resistant hypertension. (lww.com)
Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). (everydayhealth.com)
The purpose of this study is to determine if patiromer treatment in chronic kidney disease (CKD) subjects receiving spironolactone for the treatment of resistant hypertension will result i. (bioportfolio.com)
Patiromer to Enable Spironolactone Use in the Treatment of Patients with Resistant Hypertension and Chronic Kidney Disease: Rationale and Design of the AMBER Study. (bioportfolio.com)

Spironolactone tablets and suspension release the medication differently in your body and cannot be substituted for one another. (medlineplus.gov)
Your doctor may tell you not to take spironolactone if you are taking this medication. (medlineplus.gov)
I have a serious breast enlargement and entire body itching and also chronic kidney damage resulting from a medication that I am taking called Spironolactone, can you help? (lawyersandsettlements.com)
You should take this medication only after the appropriate dosages of spironolactone and hydrochlorothiazide are individually established by your doctor. (medlineplus.gov)
Spironolactone is the most commonly used medication in the treatment of hirsutism in the United States. (wikipedia.org)
In a randomized evaluation which studied people with severe congestive heart failure, people treated with spironolactone were found to have a relative risk of death of 0.70 or an overall 30% relative risk reduction compared to the placebo group, indicating a significant death and morbidity benefit of the medication. (wikipedia.org)
The pharmacodynamics of spironolactone, an antimineralocorticoid and antiandrogen medication, concern its mechanisms of action, including its biological targets and activities, as well as its physiological effects. (wikipedia.org)
Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide. (cigna.com)
In this particular post, she discussed a medication called spironolactone and how it drastically improved her skin. (popsugar.com)
After being prescribed spironolactone by Dr Mahto in 2017 , I've seen a vast improvement in my own skin and often consult the medication when my complexion flares up. (refinery29.com)
Like most medication, doses of spironolactone vary. (refinery29.com)
Like all medication, there are side-effects of spironolactone. (refinery29.com)
Spironolactone - hydrochlorothiazide may be taken with or without food, however, it should be taken the same way eachday so that levels of the medication in the body remain steady. (medbroadcast.com)
Please describe the medication: spironolactone? (healthtap.com)
If your physician has instructed or directed you to take Spironolactone medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. (internationaldrugmart.com)
Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Spironolactone, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)

calcium score (CCS) ≥ 30, detected through multi-detector computed tomography (MDCT) and expressed in Agatston units, were randomly assigned to a group receiving 25mg spironolactone per day for 12 months ( spironolactone group) and a control group not receiving this drug. (tripdatabase.com)

Mahmud A, Mahgoub M, Hall M, Feely J. Does aldosterone to renin ratio predict the antihypertensive effect of the aldosterone antagonist spironolactone? (ahajournals.org)
Canrenone is an antagonist of the MR similarly to spironolactone, but is slightly more potent in comparison. (wikipedia.org)
In accordance, 7α-TMS occurs at higher circulating concentrations than does canrenone in addition to having a higher relative affinity for the MR. Spironolactone is an antagonist of the AR, the biological target of androgens like testosterone and DHT. (wikipedia.org)
Spironolactone is an antiandrogen and aldosterone antagonist used to treat hirsutism. (mendeley.com)
Spironolactone is an antagonist of the Androgen Receptor (AR) as well as an inhibitor of Androgen production. (hairlosstalk.com)
Spironolactone is a mineralocorticoid receptor antagonist. (mindandmuscle.net)
If true, the use of a mineralocorticoid antagonist like spironolactone would reduce OSA severity in patients with resistant HTN, and thereby enhance the treatment of OSA. (ahajournals.org)
Spironolactone is a specialized antagonist of aldosterone. (aafp.org)

Take spironolactone suspension consistently either with food or without food each time. (medlineplus.gov)
Take spironolactone at around the same time(s) every day. (medlineplus.gov)
Take spironolactone exactly as directed. (medlineplus.gov)
Continue to take spironolactone even if you feel well. (medlineplus.gov)
To help you remember to take spironolactone and hydrochlorothiazide, take it around the same time(s) every day. (medlineplus.gov)
Your doctor should decide whether you take spironolactone if you are pregnant. (everydayhealth.com)
Can I take Spironolactone(Oral) if I'm pregnant or breastfeeding? (everydayhealth.com)
Take Spironolactone with a full glass of water. (internationaldrugmart.com)

The combination of spironolactone and hydrochlorothiazide is used to treat high blood pressure. (medlineplus.gov)
The combination of spironolactone and hydrochlorothiazide comes as a tablet to take by mouth. (medlineplus.gov)
The combination of spironolactone and hydrochlorothiazide, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. (lifescript.com)
tell your doctor and pharmacist if you are allergic to spironolactone, hydrochlorothiazide, sulfa drugs, or any other drugs. (lifescript.com)
If you become pregnant while taking spironolactone and hydrochlorothiazide, call your doctor. (lifescript.com)
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking spironolactone and hydrochlorothiazide. (lifescript.com)
Spironolactone and hydrochlorothiazide may cause side effects. (lifescript.com)
What is the most important information I should know about hydrochlorothiazide and spironolactone? (cigna.com)
Do not use potassium supplements while you are taking hydrochlorothiazide and spironolactone. (cigna.com)
Do not use hydrochlorothiazide and spironolactone to treat any condition (including fluid retention) that has not been checked by your doctor. (cigna.com)
Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. (cigna.com)
What should I discuss with my doctor before taking hydrochlorothiazide and spironolactone? (cigna.com)
FDA pregnancy category C. It is not known whether hydrochlorothiazide and spironolactone will harm an unborn baby. (cigna.com)
Drinking alcohol can increase certain side effects of hydrochlorothiazide and spironolactone. (cardiosmart.org)
These products could cause your potassium levels to get too high while you are taking hydrochlorothiazide and spironolactone. (cardiosmart.org)
How should I take hydrochlorothiazide and spironolactone? (cardiosmart.org)
extended these findings in reporting that low doses of spironolactone (25-50 mg) provided substantial additional antihypertensive action in both African-American and white patients when added to existing multidrug regimens, including, in all cases, an angiotensin-converting enzyme inhibitor (ACEi) or an AT1 blocker (ARB), amlodipine, and hydrochlorothiazide [2] . (lww.com)
Each round, biconvex, compressed, ivory tablet, with a peppermint aroma, engraved '25' over '25' on one side and 'novo' on the other side, contains spironolactone 25 mg and hydrochlorothiazide 25 mg. (medbroadcast.com)
Each round, biconvex, compressed, white tablet, with a peppermint aroma, engraved '50' over '50' on one side and 'novo' on the other side, contains spironolactone 50 mg and hydrochlorothiazide 50 mg. (medbroadcast.com)
The recommended adult doses range from 1 tablet (containing 25 mg spironolactone and 25 mg hydrochlorothiazide) daily to 4 tablets (containing 50 mg spironolactone and 50 mg hydrochlorothiazide) daily, taken in single or divided doses as prescribed by the doctor. (medbroadcast.com)
Hydrochlorothiazide, assess volume status and correct if necessary, such as spironolactone, start with the lowest initial dose and titrate slowly. (thedomains.com)

High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects. (wikipedia.org)
However, a small clinical study found that high doses of spironolactone had neither progestogenic nor antiprogestogenic effects in women. (wikipedia.org)

What are the side effects of spironolactone? (medicinenet.com)
In any case, if one or both of these actions are clinically relevant, they might contribute to the menstrual irregularities and breast side effects of spironolactone. (wikipedia.org)
In addition to direct antagonism of the MRs, the antimineralocorticoid effects of spironolactone may also in part be mediated by direct inactivation of 11β-hydroxylase and aldosterone synthase (18-hydroxylase), enzymes involved in the biosynthesis of mineralocorticoids. (wikipedia.org)
The onset of action of the antimineralocorticoid effects of spironolactone is relatively slow, with the peak effect sometimes occurring 48 hours or more after the first dose. (wikipedia.org)
The above data clearly illustrate the antinociceptive effects of spironolactone and the need for further studies to fully elaborate its analgesic properties. (ahajournals.org)
We evaluated the effects of spironolactone in patients with heart failure and a preserved left ventricular ejection fraction. (nih.gov)
Next, we examined the effects of spironolactone and its major metabolite, canrenone (both 100 nM), on marinobufagenin stimulation of rat cardiac fibroblasts. (omicsonline.org)
Our data suggest that some of the antifibrotic effects of spironolactone may be attributed to antagonism of marinobufagenin signaling through the sodium-potassium-ATPase. (omicsonline.org)

Spironolactone inhibits the effects of mineralocorticoids, namely, aldosterone, by displacing them from MR in the cortical collecting duct of kidney nephrons. (wikipedia.org)
Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells (it actually works on Aldosterone receptors in the collecting duct). (bionity.com)
Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. (cancer.gov)
In the distal sections of the nephron, Spironolactone inhibits the retention of sodium and water by aldosterone and suppresses the potassium-releasing effect of aldosterone, reduces the synthesis of permeases in the aldosterone-dependent region of the collecting tubules and distal tubules. (rxshop.md)
Through its action in antagonizing the effect of aldosterone, spironolactone inhibits the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. (bioportfolio.com)
Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response. (nih.gov)
Topical Spironolactone[2] inhibits DHT activity in the scalp via the same two mechanisms as Ketoconazole[3] albeit with much greater potency: androgen receptor antagonism and inhibition of the CYP17A1 enzyme. (hairlosstalk.com)

Of note, a recent randomized, double-blinded study of spironolactone in patients with symptomatic heart failure with "preserved" ejection fraction (i.e. >45%) found no reduction in death from cardiovascular events, aborted cardiac arrest, or hospitalizations when spironolactone was compared to placebo. (wikipedia.org)
Selection criteria: All randomised controlled comparisons of spironolactone versus: placebo, steroids (oral contraceptive pill included), spironolactone of varying dosages, or spironolactone and steroids versus steroids alone when used to reduce hair growth and acne in women. (mendeley.com)
[2] Patients in the study arm of the trial (those receiving spironolactone) had a relative risk of death (when compared to the placebo group) equal to 0.70 or a 30% relative risk reduction . (bionity.com)
In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction of 45% or more to receive either spironolactone (15 to 45 mg daily) or placebo. (nih.gov)
Treatment with spironolactone was associated with increased serum creatinine levels and a doubling of the rate of hyperkalemia (18.7%, vs. 9.1% in the placebo group) but reduced hypokalemia. (nih.gov)
Point out that the rate of cardiovascular mortality, aborted cardiac arrest, or heart failure hospitalization was not significantly different than placebo, but that the rate of heart failure hospitalization was significantly reduced in the spironolactone group. (medpagetoday.com)
Through an average follow-up of 3.3 years, the rate of cardiovascular mortality, aborted cardiac arrest, or heart failure hospitalization was 18.6% in the spironolactone group and 20.4% in the placebo group (hazard ratio 0.89, 95% CI 0.77-1.04), according to Marc Pfeffer, MD, PhD , of Brigham and Women's Hospital in Boston. (medpagetoday.com)
They were randomized to placebo or spironolactone with a target dose of 30 mg daily. (medpagetoday.com)
Spironolactone was clearly superior to the other interventions in reducing home SBP by −8.70 mmHg compared with placebo, −4.40 mmHg compared with bisoprolol, and −4.03 mmHg compared with doxazosin. (lww.com)
The patients will be randomized to one of 2 groups of treatment (Spironolactone 25 mg or placebo). (clinicaltrials.gov)
Patients were randomly assigned to receive placebo or 25 mg of spironolactone daily in addition to their current regimen. (aafp.org)
A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. (nih.gov)

The clinical and hormonal response to 12-month therapy with the antiandrogen, spironolactone, in conjunction with near-physiologic doses of female gonadal steroids in 50 transsexual males, is presented. (springer.com)
The most important clinical studies using Spironolactone as an Antiandrogen drug either by oral supplementation or topically, are referred. (hairlosstalk.com)
Spironolactone has been shown to affect both gonadal and adrenal steroidogenesis, to elevate plasma gonadotrophin levels in children, and to act as an antiandrogen at the target tissue level. (annals.org)

Objectives: The objective was to investigate the effectiveness of spironolactone and/or in combination with steroids (oral contraceptive pill included) in reducing excess hair growth and/or acne in women. (mendeley.com)
Spironolactone was tested by oral administration in one study in rats. (inchem.org)
Optimizing the Trial Design for a Comparative Effectiveness Study of Spironolactone versus Oral Antibiotics for Women With Acne: A Delphi Consensus Panel. (harvard.edu)
What is Spironolactone(Oral) used for? (everydayhealth.com)
Use Spironolactone(Oral) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
I finally was referred to a dermatologist who diagnosed me with androgenic alopecia and she prescribed 0.25 mg of oral monoxidil in combination with spironolactone. (heralopecia.com)
I can't find a lot of stories online about oral minoxidil in combination with Spironolactone. (heralopecia.com)
I have been on oral Minoxidil and low dose spironolactone since April 2018 and was prescribed the same dose as you. (heralopecia.com)
Other what is the classification of spironolactone oral contraceptive failure with a single :agent leukotriene receptor blockade may be accom- panied by jet nebulizer. (musicaenlamochila.net)
About CaroSpir CaroSpir (spironolactone oral suspension) is indicated for treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema and to reduce the need for hospitalization for heart failure, and is usually administered in conjunction with other therapies. (medindia.net)
CAROSPIR oral suspension, 25 mg/5 mL, is not therapeutically equivalent to tablet forms of spironolactone. (medindia.net)
I read a dermatalogical journal online that revealed that when spironolactone is combined with an oral contraceptive the success rate jumps from 66% of women to 88% of women. (acne.org)

Do not stop taking spironolactone without talking to your doctor. (medlineplus.gov)
How Do I Stop Taking Spironolactone? (medications.com)
Ellen Marmur, a New York City dermatologist, posted a video to her feed on March 21 in which she recommends that her patients stop taking spironolactone, also called spiro. (vice.com)

What is the dosage for spironolactone? (medicinenet.com)
One of the dosage forms available for Spironolactone is Transdermal Gel. (wedgewoodpharmacy.com)
Spironolactone is also available in these dosage forms. (wedgewoodpharmacy.com)
What is the recommended dosage of Spironolactone? (internationaldrugmart.com)
The dosage of Spironolactone prescribed to each patient will vary. (internationaldrugmart.com)

Drugs such as spironolactone act as antagonists of aldosterone and compete with it for its site of action in the distal tubule. (britannica.com)
Which drugs or supplements interact with spironolactone? (medicinenet.com)
Individual study data indicates some superiority of spironolactone over other drugs but results cannot be generalised. (mendeley.com)
What other drugs could interact with Spironolactone? (internationaldrugmart.com)
It may be noted that drugs other than those listed above may also interact with Spironolactone. (internationaldrugmart.com)

Your doctor may start you on a low dose of spironolactone and gradually increase your dose. (medlineplus.gov)
The purpose of this study is to evaluate if the drug spironolactone - which is used to treat acne and male pattern hair growth in women - is effective in treating hidradenitis suppurativa in females and which dose of the drug works the best. (clinicaltrials.gov)
If a physician did choose to use spironolactone, he said, "we also show how it can be safely done by monitoring potassium and creatinine and using a low dose. (medpagetoday.com)
Following the initial visit, all 50 were begun on spironolactone and low-dose female hormone therapy. (springer.com)
Association Between High-Dose Spironolactone and Decongestion in Patients with Acute Heart Failure: An Observational Retrospective Study. (springer.com)
[1] reported in 2002 that a spironolactone dose of 1 mg/kg of body weight per day reduced 24-h ambulatory SBP and DBP by 24 and 10 mmHg, respectively, in 25 patients with uncontrolled BP on an average of three medications. (lww.com)
The effect of food on spironolactone absorption (two 100 mg spironolactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. (bioportfolio.com)
Spironolactone dose in heart failure with preserved ejection fraction: findings from TOPCAT. (harvard.edu)
The dose β2-agonists are therefore relax arteriolar what is the classification of spironolactone smooth muscle damage. (musicaenlamochila.net)
In patients requiring a dose greater than 100 mg, use another formulation of spironolactone. (medindia.net)
I definitely think you should tell your derm that you can tolerate a higher dose of spironolactone. (acne.org)
The undiminished dose of spironolactone was 25 mg interquartile vulture: 25 to 50 mg at both the best and end of the observation estrogen. (thedomains.com)
What if you miss a dose of Spironolactone? (internationaldrugmart.com)

or any of the ingredients in spironolactone tablets. (medlineplus.gov)
These highlights do not include all the information needed to use SPIRONOLACTONE TABLETS safely and effectively. (nih.gov)
See full prescribing information for SPIRONOLACTONE TABLETS. (nih.gov)
Generic versions are sold under the name of spironolactone tablets. (sharecare.com)
Spironolactone tablets come in three strengths: 25 mg., 50 mg. and 100 mg. (sharecare.com)
The purpose of this study is to determine which combination of the tablets ramipril, irbesartan or spironolactone is best to lower protein leakage from the kidney. (bioportfolio.com)
provides a stable, ready to use and consistent liquid treatment option for adult patients, including those who have difficulty swallowing, or who cannot swallow tablets ," said Gerald Sakowski , CEO at CMP Pharma, Inc. "Up until now, these patients have been prescribed a pharmacy compounded liquid form of spironolactone. (medindia.net)
Spironolactone is rapidly metabolized as it is shown by the mean Tmax of metabolites: 7TM and CAN Tmax are respectively 1.56 +/- 0.45 hours and 2.54 +/- 1.06 hours after administration of 1 tablet, or 1.58 +/- 0.42 hours and 2.67 +/- 1.13 hours after administration of 2 tablets. (sigmaaldrich.com)

What conditions does Spironolactone/HCTZ Tablet treat? (webmd.com)
List Spironolactone/HCTZ Tablet side effects by likelihood and severity. (webmd.com)

Spironolactone is a well-known cause of gynecomastia and may act by displacing androgen from the androgen receptor and sexual-hormone-binding globulin, and by causing increased metabolic clearance of testosterone and higher estradiol production. (cmaj.ca)
Thus, spironolactone does alter the peripheral metabolism of testosterone resulting in changes in the ratio of testosterone to estradiol, which could contribute to the production of gynecomastia. (annals.org)
If you follow enough trans women on Twitter, you might have seen a panic break out earlier this week over concerns that spironolactone, a testosterone blocker that many of us take as part of hormone replacement therapy that is also widely prescribed to the general population to treat hormonal acne , increases one's risk for developing COVID-19. (vice.com)
Spironolactone blocks testosterone action. (healthtap.com)

I was taking spironolactone for about a year to treat acne. (lawyersandsettlements.com)
I was on Spironolactone for about 10-12 years for severe acne and the side effects were tolerable up until almost 2 years ago then I started getting horrible acid reflux. (lawyersandsettlements.com)
For Acne I'm 42 and began taking spironolactone and using Differin for adult acne about a year ago. (drugs.com)
Since november I have been taking 100mg once a day of spironolactone used as off label acne medicine. (babycenter.com)
Authors' conclusions: From the studies included in this review, there is some evidence to show that spironolactone is an effective treatment to decrease the degree of hirsutism but there was no evidence for effectiveness for the treatment of acne vulgaris. (mendeley.com)
Can You Use Spironolactone to Treat Acne? (popsugar.com)
I also tapped into the knowledge of GP Dr. Ross Perry to find out if spironolactone is safe to use as an acne treatment. (popsugar.com)
She heard about spironolactone when researching polycystic ovarian syndrome (PCOS) , which is another common cause of acne. (popsugar.com)
As with any condition, if you're having persistent and severe acne and have explored other options, visit your dermatologist to ask about trying spironolactone to find out how it may work for you. (popsugar.com)
Defeated, but still not desperate enough to resort to trying birth control or Accutane, my dermatologist suggested spironolactone , a prescription blood pressure pill that also can clear up hormonal acne. (instyle.com)
Spironolactone is an 'off-label' drug which means it is not licensed in the UK for the treatment of acne," explains Dr Anjali Mahto , consultant dermatologist and author of The Skincare Bible: Your No-Nonsense Guide To Great Skin . (refinery29.com)
Spironolactone is used more widely in North America and produces good clinical results, especially for female adult acne or acne in the context of PCOS ( polycystic ovary syndrome )," adds Dr Mahto, who often prescribes the drug in clinic. (refinery29.com)
Here's everything you need to know before taking spironolactone to treat your hormonal acne. (refinery29.com)
Similar to other acne medications, spironolactone isn't usually instant. (refinery29.com)
Experts recommend pairing spironolactone with proven acne-fighting ingredients. (refinery29.com)
Temporal Trends and Clinician Variability in Potassium Monitoring of Healthy Young Women Treated for Acne With Spironolactone. (harvard.edu)
Long-term use of spironolactone for acne in women: A case series of 403 patients. (harvard.edu)
Comparative analysis of prescribing patterns of tetracycline class antibiotics and spironolactone between advanced practice providers and physicians in the treatment of acne vulgaris. (harvard.edu)
Will the acne get worse during pregnancy when my hormones are in a hyperdynamic state and I am not on spironolactone? (hormonehelpny.com)
Spironolactone usually should be continued for as long as acne is active. (hormonehelpny.com)
Spironolactone has been used by people with acne for a long time, for the same reason it's beneficial for hair loss. (hairlosstalk.com)
I recently stop using spironolactone that was prescribed for acne. (healthtap.com)
At 35 I still have severe acne have used accutan, spironolactone, differin (adapalene). (healthtap.com)
Spironolactone for Acne - How It Works And Should You Try It? (facingacne.com)
Have you ever considered using spironolactone for acne treatment ? (facingacne.com)
Hormones play a big part in acne, and spironolactone can help. (facingacne.com)
Spironolactone is an anti-androgen, which we will explain more about in a moment, but generally speaking, it can suppress the hormones that promote acne 1 . (facingacne.com)
This article will explain what causes acne and how spironolactone can help, who usually benefits the most from using spironolactone for acne, and some other acne treatment options if spironolactone isn't for you. (facingacne.com)
If you've tried almost every acne treatment out there and you've never heard of using spironolactone for acne, there's a good reason for that: it wasn't actually meant for acne. (facingacne.com)
These conditions are obviously very different from acne, so it makes sense if spironolactone hasn't exactly been on your radar. (facingacne.com)
Dermatologists discovered they could use spironolactone for acne because it doesn't just block aldosterone, it's also an anti-androgen. (facingacne.com)
Before visiting a new doctor, Lang did her own research and stumbled upon spironolactone while looking into polycystic ovarian syndrome or PCOS, which is a hormonal disorder known to cause acne. (thedomains.com)

Spironolactone controls high blood pressure, edema, heart failure, and hyperaldosteronism but does not cure these conditions. (medlineplus.gov)
Used for congestive heart failure that was supposed to save lives, Spironolactone also caused dozens of deaths from a side effect when doctors began prescribing it more widely. (lawyersandsettlements.com)
A major study five years ago found that adding spironolactone to the standard treatments cut the death rate by 30 percent in people with serious heart failure. (lawyersandsettlements.com)
Spironolactone is also indicated for patients with congestive heart failure taking digitalis when other therapies are considered inappropriate. (nih.gov)
The most common use of spironolactone is in the treatment of heart failure. (wikipedia.org)
According to a systematic review, in heart failure with preserved ejection fraction, treatment with spironolactone did not improve patient outcomes. (wikipedia.org)
Spironolactone for heart failure with preserved ejection fraction. (nih.gov)
In patients with heart failure and a preserved ejection fraction, treatment with spironolactone did not significantly reduce the incidence of the primary composite outcome of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure. (nih.gov)
The TOPCAT trial evaluating spironolactone in patients with heart failure and preserved ejection fraction did not meet its primary endpoint, but there was some evidence of benefit. (medpagetoday.com)
The rate of heart failure hospitalization was, however, significantly reduced in the spironolactone group (12% versus 14.2%, HR 0.83, 95% CI 0.69-0.99), with no differences in the other components of the primary endpoint, he reported at the American Heart Association meeting . (medpagetoday.com)
He said physicians will have to choose whether the reduction in heart failure hospitalization is enough to justify using spironolactone in these patients, in whom there are no proven treatments. (medpagetoday.com)
Allan Anderson, MD , a cardiologist at Scott & White Hospital in Texas, commented that "based on these results, spironolactone should be used cautiously in the [heart failure with preserved ejection fraction] population. (medpagetoday.com)
Mineralocorticoid receptor antagonists like spironolactone have been shown to be beneficial in heart failure with reduced ejection fraction, but that hasn't been translated into patients with reduced ejection fraction, Pfeffer said. (medpagetoday.com)
The TOPCAT trial , which was conducted at 270 centers in six countries, evaluated the use of spironolactone in a larger population of patients with heart failure and preserved ejection fraction -- 3,445 enrolled from the U.S., Canada, Brazil, Argentina, Russia, and the Republic of Georgia. (medpagetoday.com)
The overall clinical outcome was no different between the two groups, although heart failure hospitalizations were lower in the spironolactone group. (medpagetoday.com)
Spironolactone is a medicine used to treat people with various conditions, including high blood pressure, low potassium levels, heart failure, edema, liver disease, kidney disease, and hyperaldosteronism (a condition in which the body produces too much of the hormone aldosterone). (everydayhealth.com)
Spironolactone in Left-Sided Heart Failure: How Does It Fit In? (aafp.org)
A proof of concept trial examining spironolactone for heart failure prevention presented at HFSA 2019 found spironolactone use did reduce PIIINP or that its impact on PIIINP was mitigated by galectin-3. (hcplive.com)
Results of the Heart Omics and Aging (HOMAGE) Proof of Concept Trial of Spironolactone for the Prevention of Heart Failure are offering cardiologists more insight on the impact of spironolactone treatment on cardiovascular health . (hcplive.com)
The results of the study, which were presented during the Heart Failure Society of America 2019 Scientific Sessions in Philadelphia, revealed that spironolactone did not decrease Procollagen type III N-Terminal Peptide (PIIINP) or its effect on PIIINP was modified by galectin-3 (Gal-3). (hcplive.com)
This study, "Heart Omics and Aging (HOMAGE) Proof of Concept Trial of Spironolactone for the Prevention of Heart Failure," was presented at HFSA 2019. (hcplive.com)
Alongside spironolactone therapy, infectious blood pressure fell from Spironolactone sacks morbidity and mortality in clinical heart failure, 2 and early lowers blood pressure BP in healthy patients with and without hyperaldosteronism. (thedomains.com)
If you haven't heard of spironolactone, it's a prescription drug used to treat health issues like high blood pressure and heart failure. (thedomains.com)
Spironolactone is prescribed to treat fluid retention in people with congestive heart failure, liver cirrhosis, and nephrotic syndrome. (internationaldrugmart.com)
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. (nih.gov)
This 30 percent reduction in the risk of death among patients in the spironolactone group was attributed to a lower risk of both death from progressive heart failure and sudden death from cardiac causes. (nih.gov)
Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure. (nih.gov)

Spironolactone is in a class of medications called aldosterone receptor antagonists. (medlineplus.gov)
As with most antagonists, spironolactone has no direct action of its own but simply prevents the action of the hormone, thereby correcting the excess sodium reabsorption. (britannica.com)

This effect may contribute to the drug interactions of spironolactone. (wikipedia.org)

I took spironolactone for 2 months in 2018. (lawyersandsettlements.com)

in these persons the antihypertensive effect of spironolactone may exceed that of complex combined regimens of other antihypertensives. (bionity.com)

More people need to be warned of these harsh side effects about Spironolactone. (lawyersandsettlements.com)
See the full spironolactone side effects document. (drugs.com)
Therapy with spironolactone is often associated with estrogenlike side-effects, including impotence and gynecomastia in men and menstrual irregularity in women. (annals.org)
Several possible mechanisms by which spironolactone could cause these side-effects have been identified. (annals.org)
This conference presents a discussion of how these effects might interact to produce the endocrine side effects associated with spironolactone therapy. (annals.org)

Likely due to increased activation of the estrogen and/or progesterone receptors, spironolactone has very weak but significant antigonadotropic effects. (wikipedia.org)
Aside from its primary mechanisms of action of antimineralocorticoid and antiandrogenic action, spironolactone has been found in preclinical research to interact very weakly with the progesterone and estrogen receptors and to have very weak mixed progestogenic and antiprogestogenic activity as well as very weak mixed estrogenic and antiestrogenic activity. (wikipedia.org)
2 Spironolactone also attenuates microglia activation, as well as causes downregulation of N-Methyl-D-aspartate (NMDA) receptors in the dorsal root ganglions. (ahajournals.org)
4 This synergistic effect of spironolactone is mediated by its antagonistic effect on mineralocorticoid receptors. (ahajournals.org)
Relative to spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. (bioportfolio.com)
Spironolactone blocks androgen receptors. (healthtap.com)

Digoxin: Spironolactone can interfere with radioimmunologic assays of digoxin exposure ( 7.4 ). (nih.gov)
Interaction of spironolactone and digoxin in dogs. (aspetjournals.org)

progesterone abnormally high during or after spironolactone? (medications.com)

Spironolactone has caused tumors in laboratory animals. (medlineplus.gov)
In animal studies, spironolactone caused certain types of tumors. (cigna.com)
Spironolactone has caused tumors in animals but it is not known whether this could occur in people. (uofmhealth.org)
In vivo, spironolactone treatment reduced the size and CSC content of tumors. (nih.gov)

The major active forms of spironolactone include 7α-thiomethylspironolactone (7α-TMS) and canrenone (7α-desthioacetyl-δ6-spironolactone), while more minor metabolites of spironolactone include 7α-thiospironolactone (7α-TS), 6β-hydroxy-7α-thiomethylspironolactone (6β-OH-7α-TMS), and a number of others. (wikipedia.org)
Conversely, the affinity of canrenone for the AR was found to be 0.84% of that of DHT in another study, relative to 67% for spironolactone. (wikipedia.org)
However, another study found the affinity of canrenone for the AR to be 2.5 to 14%, relative to 4.1 to 31% in the case of spironolactone. (wikipedia.org)
Another study that directly compared the affinities of spironolactone and canrenone reported that spironolactone had 5-fold higher affinity for the AR than canrenone (5% and 1% of that of DHT, respectively). (wikipedia.org)
Studies of spironolactone and the related compound potassium canrenoate (which, like spironolactone, metabolizes to canrenone) in rats for one to two year periods show an increase in carcinogenesis in the thyroid gland, testes, liver, breasts, and myelocytic leukocytes. (bionity.com)
Both spironolactone and canrenone prevented the stimulation of collagen production by 1 nM marinobufagenin but not 100 nM marinobufagenin, as assessed by proline incorporation and procollagen 1 expression, as well as signaling through the sodium-potassium-ATPase, as evidenced by protein kinase C isoform delta translocation and extracellular signal regulated kinase 1/2 activation. (omicsonline.org)
Both spironolactone and canrenone also altered ouabain binding to cultured porcine cells in a manner consistent with competitive inhibition. (omicsonline.org)

I am on Tri-Sprintec and 100mg of spironolactone. (acne.org)

Here we show that spironolactone, apart from inhibiting cancerous cell growth, is also highly toxic to CSCs. (nih.gov)

Treatment with spironolactone reduces the severity of OSA in patients with resistant HTN, supporting the hypothesis that aldosterone excess worsens OSA. (ahajournals.org)
Participants - Cases were residents of Ontario aged 66 years or above receiving chronic treatment with spironolactone and admitted to hospital with hyperkalaemia within 14 days of receiving a prescription for either trimethoprim-sulfamethoxazole, amoxicillin, norfloxacin, or nitrofurantoin. (ices.on.ca)

Objectives - To characterise the risk of admission to hospital for hyperkalaemia in elderly patients treated with trimethoprim-sulfamethoxazole in combination with spironolactone. (ices.on.ca)

What are the warnings and precautions for Spironolactone? (medindia.net)

Treatment of hirsutism with spironolactone. (springer.com)
Spironolactone is the most commonly used drug in the treatment of hirsutism in the United States. (hairlosstalk.com)
I have read that treatment of hirsutism with spironolactone can show positive results within about six months. (hormonehelpny.com)
Hirsutism (increased hair growth on a woman) usually improves considerably with spironolactone. (hormonehelpny.com)

Previously we have found that the antihypertensive drug spironolactone impairs DNA damage response in cancer cells. (nih.gov)

Sixteen subjects were randomized in open-label fashion to either spironolactone 25-50 mg daily or routine care (addition/titration of antihypertensive medications). (ahajournals.org)

Local inhibition of androgen activity is exactly what Topical Spironolactone does. (hairlosstalk.com)
Is there Data supporting Topical Spironolactone? (hairlosstalk.com)
From that perspective, Topical Spironolactone is a rock star among the myriad of questionable treatments out there. (hairlosstalk.com)
A medical research supply company out of China that supplies quite a few ingredients to major companies around the world is now offering a topical spironolactone formula for hair loss sufferers. (hairlosstalk.com)

Can a regular doctor prescribe spironolactone or only dermatologists? (healthtap.com)

Order Cheap medications at the Best Prices spironolactone buy . (spiritofbaraka.com)

It is recommended that alternatives to spironolactone be considered if serum creatinine is greater than 2.5 mg/dL (221 μmol/L) in males or greater than 2 mg/dL (176.8 μmol/L) in females, if glomerular filtration rate is below 30 mL/min or with a serum potassium of greater than 5.0 mEq/L given the potential for adverse events detailed elsewhere in this article. (wikipedia.org)
Similarly, spironolactone decreases diabetes mellitus-associated hyperalgesia by mitigating diabetes mellitus-associated elevations in nitric oxide levels in the serum. (ahajournals.org)
This study was also informative in reporting that the antihypertensive benefit of spironolactone was not limited to patients with apparent hyperaldosteronism in that the degree of BP reduction was similar regardless of serum or 24-h urinary aldosterone levels. (lww.com)
Spironolactone has not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. (bioportfolio.com)
Additionally, investigators pointed out that spironolactone use increase serum K+ and decreased eGFR without symptoms or clinical impact. (hcplive.com)

Spironolactone Altizide Pfizer may be available in the countries listed below. (drugs.com)

Sulfur-containing products are the predominant metabolites and are thought to be primarily responsible, together with spironolactone, for the therapeutic effects of the drug. (bioportfolio.com)

Allergy to furosemide or spironolactone. (netdoctor.co.uk)
My toy poodle required 4 mg. of Spironolactone 2xs/day & 2 mg. of Furosemide 2xs/day. (1800petmeds.com)
Furosemide is scored, spironolactone is not. (1800petmeds.com)

The pharmacological activity of spironolactone metabolites in man is not known. (bioportfolio.com)
Spironolactone and its metabolites are more than 90% bound to plasma proteins. (bioportfolio.com)

However, the use of spironolactone in patients with chronic kidney disease can be restricted by hyperkalaemia. (tripdatabase.com)
Hyperkalaemia is the most common side-effect of exposure to spironolactone in humans, and a number of endocrine effects have been observed, the most common of which is gynaecomastia in men. (inchem.org)
The population attributable fraction was 59.7%, suggesting that approximately 60% of all cases of hyperkalaemia in older patients taking spironolactone and treated with an antibiotic for a urinary tract infection could be avoided if trimethoprim-sulfamethoxazole was not prescribed. (ices.on.ca)
Conclusions - Among older patients receiving spironolactone, treatment with trimethoprim-sulfamethoxazole was associated with a major increase in the risk of admission to hospital for hyperkalaemia. (ices.on.ca)

Anatomy1

Diseases11

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes2

Disciplines and Occupations1

Technology, Industry, Agriculture1

Health Care1

Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. (1/759)

Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. (2/759)

Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats. (3/759)

Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. (4/759)

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. (5/759)

Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms. (6/759)

Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia. (7/759)

Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. (8/759)

Spironolactone

Mineralocorticoid Receptor Antagonists

Canrenone

Aldosterone

Hyperkalemia

Canrenoic Acid

Receptors, Mineralocorticoid

Diuretics

Pregnadienes

Fludrocortisone

Bendroflumethiazide

Triamterene

Hyperaldosteronism

Gynecomastia

Mineralocorticoids

Heart Failure

Potassium

Hypokalemia

Renin

Endomyocardial Fibrosis

Sodium Chloride Symporter Inhibitors

Hirsutism

Angiotensin-Converting Enzyme Inhibitors

Chlorthalidone

Mifepristone

Hypertension

Blood Pressure

Digoxin

Metolazone

Hydrochlorothiazide

Drug Therapy, Combination

Chlorothiazide

Double-Blind Method

Furosemide

Fibrosis

Angiotensin II Type 1 Receptor Blockers

11-beta-Hydroxysteroid Dehydrogenase Type 2

Adrenalectomy

Dihydralazine

Amiloride

Procollagen

Sodium Potassium Chloride Symporter Inhibitors

Alopecia

Endocrinology

Alopecia Areata

Hair

5-alpha Reductase Inhibitors

Protective Devices

Syringes

Blood Pressure Determination

Pressure

Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. (1/759)

Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. (2/759)

Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats. (3/759)

Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. (4/759)

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. (5/759)

Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms. (6/759)

Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia. (7/759)

Effect of poststroke captopril treatment on mortality associated with hemorrhagic stroke in stroke-prone rats. (8/759)

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