Spindle apparatus. Medical search

A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.

A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).

The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.

A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.

A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.

Skeletal muscle structures that function as the MECHANORECEPTORS responsible for the stretch or myotactic reflex (REFLEX, STRETCH). They are composed of a bundle of encapsulated SKELETAL MUSCLE FIBERS, i.e., the intrafusal fibers (nuclear bag 1 fibers, nuclear bag 2 fibers, and nuclear chain fibers) innervated by SENSORY NEURONS.

A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.

Large multiprotein complexes that bind the centromeres of the chromosomes to the microtubules of the mitotic spindle during metaphase in the cell cycle.

The phase of cell nucleus division following PROMETAPHASE, in which the CHROMOSOMES line up across the equatorial plane of the SPINDLE APPARATUS prior to separation.

A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.

Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.

Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.

A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.

In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis to power a variety of cellular functions. Dyneins fall into two major classes based upon structural and functional criteria.

The final phase of cell nucleus division following ANAPHASE, in which two daughter nuclei are formed, the CYTOPLASM completes division, and the CHROMOSOMES lose their distinctness and are transformed into CHROMATIN threads.

The cellular signaling system that halts the progression of cells through MITOSIS or MEIOSIS if a defect that will affect CHROMOSOME SEGREGATION is detected.

The process by which the CYTOPLASM of a cell is divided.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Proteins found in the microtubules.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Motor neurons which activate the contractile regions of intrafusal SKELETAL MUSCLE FIBERS, thus adjusting the sensitivity of the MUSCLE SPINDLES to stretch. Gamma motor neurons may be "static" or "dynamic" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length.

Self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

The first phase of cell nucleus division, in which the CHROMOSOMES become visible, the CELL NUCLEUS starts to lose its identity, the SPINDLE APPARATUS appears, and the CENTRIOLES migrate toward opposite poles.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

The phase of cell nucleus division following PROPHASE, when the breakdown of the NUCLEAR ENVELOPE occurs and the MITOTIC SPINDLE APPARATUS enters the nuclear region and attaches to the KINETOCHORES.

An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.

The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

The property of nonisotropic media, such as crystals, whereby a single incident beam of light traverses the medium as two beams, each plane-polarized, the planes being at right angles to each other. (Cline et al., Dictionary of Visual Science, 4th ed)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.

A monomeric GTP-binding protein involved in nucleocytoplasmic transport of proteins into the nucleus and RNA into the cytoplasm. This enzyme was formerly listed as EC 3.6.1.47.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The interval between two successive CELL DIVISIONS during which the CHROMOSOMES are not individually distinguishable. It is composed of the G phases (G1 PHASE; G0 PHASE; G2 PHASE) and S PHASE (when DNA replication occurs).

Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.

Drosophila oogenesis: versatile spn doctors. (1/4092)

Recent work on Drosophila oogenesis has uncovered connections between cell-cycle checkpoints and pattern formation. Genes of the spindle class, which encode double-strand break repair enzymes and RNA helicases, affect oocyte polarity and the decision whether to differentiate as an oocyte or a nurse cell. (+info)

C-myc overexpression and p53 loss cooperate to promote genomic instability. (2/4092)

p53 monitors genomic integrity at the G1 and G2/M cell cycle checkpoints. Cells lacking p53 may show gene amplification as well as the polyploidy or aneuploidy typical of many tumors. The pathways through which this develops, however, are not well defined. We demonstrate here that the combination of p53 inactivation and c-myc overexpression in diploid cells markedly accelerates the spontaneous development of tetraploidy. This is not seen with either N-myc or L-myc. Tetraploidy is accompanied by significantly higher levels of cyclin B and its associated cdc2 kinase activity. Mitotic spindle poisons accelerate the appearance of tetraploidy in cells either lacking functional p53 or overexpressing c-myc whereas the combination is additive. Restoration of p53 function in cells overexpressing c-myc causing rapid apoptosis, indicating that cells yet to become tetraploid have nonetheless suffered irreversible genomic and/or mitotic spindle damage. In the face of normal p53 function, such damage would either be repaired or trigger apoptotis. We propose that loss of p53 and overexpression of c-myc permits the emergence and survival of cells with increasingly severe damage and the eventual development of tetraploidy. (+info)

Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. (3/4092)

A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity. Point-of-execution experiments indicate Glc7p function is required in G2/M just before anaphase for the completion of mitosis. Loss of the spindle/kinetochore checkpoint in glc7-129 cells abolishes the G2/M cell cycle arrest with a concomitant increase in chromosome loss and reduced viability. These results support a role for Glc7p in regulating kinetochore attachment to the spindle, an event monitored by the spindle/kinetochore checkpoint. (+info)

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. (4/4092)

Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister chromatids but are defective in chromosome segregation. Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules. Ipl1p phosphorylates the kinetochore component Ndc10p in vitro and we propose that Ipl1p regulates kinetochore function via Ndc10p phosphorylation. Ipl1p localizes to the mitotic spindle and its levels are regulated during the cell cycle. This pattern of localization and regulation is similar to that of Ipl1p homologs in higher eukaryotes, such as the human aurora2 protein. Because aurora2 has been implicated in oncogenesis, defects in kinetochore function may contribute to genetic instability in human tumors. (+info)

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. (5/4092)

The product of the abnormal spindle (asp) gene was found to be an asymmetrically localized component of the centrosome during mitosis, required to focus the poles of the mitotic spindle in vivo. Removing Asp protein function from Drosophila melanogaster embryo extracts, either by mutation or immunodepletion, resulted in loss of their ability to restore microtubule-organizing center activity to salt-stripped centrosome preparations. This was corrected by addition of purified Asp protein. Thus, Asp appears to hold together the microtubule-nucleating gamma-tubulin ring complexes that organize the mitotic centrosome. (+info)

Influence of centriole behavior on the first spindle formation in zygotes of the brown alga Fucus distichus (Fucales, Phaeophyceae). (6/4092)

The influence of centrioles, derived from the sperm flagellar basal bodies, and the centrosomal material (MTOCs) on spindle formation in the brown alga Fucus distichus (oogamous) was studied by immunofluorescence microscopy using anti-centrin and anti-beta-tubulin antibodies. In contrast to a bipolar spindle, which is formed after normal fertilization, a multipolar spindle was formed in polyspermic zygote. The number of mitotic poles in polyspermic zygotes was double the number of sperm involved in fertilization. As an anti-centrin staining spot (centrioles) was located at these poles, the multipolar spindles in polyspermic zygotes were produced by the supplementary centrioles. When anucleate egg fragments were fertilized, chromosome condensation and mitosis did not occur in the sperm nucleus. Two anti-centrin staining spots could be detected, microtubules (MTs) radiated from nearby, but the mitotic spindle was never produced. When a single sperm fertilized multinucleate eggs (polygyny), abnormal spindles were also observed. In addition to two mitotic poles containing anti-centrin staining spots, extra mitotic poles without anti-centrin staining spots were also formed, and as a result multipolar spindles were formed. When karyogamy was blocked with colchicine, it became clear that the egg nucleus proceeded independently into mitosis accompanying chromosome condensation. A monoastral spindle could be frequently observed, and in rare cases a barrel-shaped spindle was formed. However, when a sperm nucleus was located near an egg nucleus, the two anti-centrin staining spots shifted to the egg nucleus from the sperm nucleus. In this case, a normal spindle was formed, the egg chromosomes arranged at the equator, and the associated MTs elongated from one pole of the egg spindle toward the sperm chromosomes which were scattered. From these results, it became clear that paternal centrioles derived from the sperm have a crucial role in spindle formation in the brown algae, such as they do during animal fertilization. However, paternal centrioles were not adequate for the functional centrosome during spindle formation. We speculated that centrosomal materials from the egg cytoplasm aggregate around the sperm centrioles and are needed for centrosomal activation. (+info)

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice. (7/4092)

NuMA is a nuclear matrix protein in interphase and relocates to the spindle poles in mitotis. Different NuMA constructs, in which either N- or C-terminal domains were deleted, and the full-length construct were expressed in Escherichia coli, and the NuMA polypeptides were purified to homogeneity and allowed to assemble in vitro. Electron microscopy showed that NuMA can build multiarm oligomers by interaction of the C-terminal globular domains. Each arm of the oligomer corresponds to a NuMA dimer. Oligomers with up to 10 or 12 arms have been observed for both full-length NuMA and for constructs that still contain the proximal part of the C-terminal tail domain. Other results from this laboratory have shown that transient overexpression of NuMA in HeLa cells induces a nuclear scaffold with a quasi-hexagonal organization that can fill the nuclei. Here we show that computer modelling of the three-dimensional packing of NuMA into such scaffolds can explain the different spacing of the hexagons seen when constructs with different coiled-coil lengths are used. Thus, the 12 arm oligomer, for which we have in vitro evidence, may be the structural unit from which the nuclear scaffold in transfected cells is built. (+info)

Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. (8/4092)

Alignment of the mitotic spindle with the axis of cell division is an essential process in Saccharomyces cerevisiae that is mediated by interactions between cytoplasmic microtubules and the cell cortex. We found that a cortical protein, the yeast formin Bni1p, was required for spindle orientation. Two striking abnormalities were observed in bni1Delta cells. First, the initial movement of the spindle pole body (SPB) toward the emerging bud was defective. This phenotype is similar to that previously observed in cells lacking the kinesin Kip3p and, in fact, BNI1 and KIP3 were found to be in the same genetic pathway. Second, abnormal pulling interactions between microtubules and the cortex appeared to cause preanaphase spindles in bni1Delta cells to transit back and forth between the mother and the bud. We therefore propose that Bni1p may localize or alter the function of cortical microtubule-binding sites in the bud. Additionally, we present evidence that other bipolar bud site determinants together with cortical actin are also required for spindle orientation. (+info)

Cells divide along the line connecting two centrosomes of the spindle apparatus. After formation, the spindle apparatus ... The cellular spindle apparatus includes the spindle microtubules, associated proteins, which include kinesin and dynein ... The spindle apparatus is vaguely ellipsoid in cross section and tapers at the ends. In the wide middle portion, known as the ... Media related to Spindle apparatus at Wikimedia Commons (CS1 maint: multiple names: authors list, Articles with short ...

https://en.wikipedia.org/wiki/Spindle_apparatus

meiotic spindle See spindle apparatus. melting The denaturation of a double-stranded nucleic acid into two single strands, ... mitotic recombination mitotic segregation mitotic spindle See spindle apparatus. mixoploidy The presence of more than one ... spectral karyotype (SKY) spindle apparatus spliceosome splicing See genetic engineering. split-gene ssDNA See single-stranded ... and the mitotic spindle forms. protein A linear polymeric macromolecule composed of a series of amino acids linked by peptide ...

https://en.wikipedia.org/wiki/Glossary_of_genetics_(M−Z)

Ptacin, JL; Lee, SF; Garner, EC; Toro, E; Eckart, M; Comolli, LR; Moerner, WE; Shapiro, L (Aug 2010). "A spindle-like apparatus ... "Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus". Cell Systems. 1 (2): 163-73. doi: ...

https://en.wikipedia.org/wiki/ParABS_system

During mitosis Par14 associates to the spindle apparatus. In vitro experiments demonstrated that Par14 may be involved in ...

https://en.wikipedia.org/wiki/Parvulin_14

The spindle apparatus rotates in the round cell and after several minutes the spindle position is stabilised preferentially ... It is at this rounding stage that the decision on the orientation of the cell division is made by the spindle apparatus. ... The cell then divides along the spindle apparatus orientation. The first insights into how cells could remember their long axis ... the rule emphasizes the cell shape as a default mechanism of spindle apparatus orientation. Hertwig's rule predicts cell ...

https://en.wikipedia.org/wiki/Hertwig_rule

meiotic spindle See spindle apparatus. melting The denaturation of a double-stranded nucleic acid into two single strands, ... mitotic recombination mitotic segregation mitotic spindle See spindle apparatus. mixoploidy The presence of more than one ... spectral karyotype (SKY) spindle apparatus spliceosome splicing See genetic engineering. split-gene ssDNA See single-stranded ... and the spindle apparatus begins to extend from the poles to the equator. dicentric (of a linear chromosome or chromosome ...

https://en.wikipedia.org/wiki/Glossary_of_genetics

This requires the spindle apparatus in these cells to be asymmetric. She discovered a role for proteins that control actin ... She found that human oocytes have a surprisingly slow and error-prone mechanism for assembling the meiotic spindle, increasing ... In studying how actin helps position the spindle, she discovered that vesicles carrying specific signals can change the ... Schuh, Melina; Ellenberg, Jan (23 December 2008). "A new model for asymmetric spindle positioning in mouse oocytes". Current ...

https://en.wikipedia.org/wiki/Melina_Schuh

The funnel locking-apparatus are small and oval to spindle-shaped. A single cartilaginous tubercle is present at the mantle ... In this posture, they rotate around their spindle-shaped digestive glands, the only internal organs of the squid clearly ...

https://en.wikipedia.org/wiki/Teuthowenia_megalops

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the ... 2003). "The mitotic-spindle-associated protein astrin is essential for progression through mitosis". J. Cell Sci. 115 (Pt 21): ... Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds ... 2007). "hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases" (PDF ...

https://en.wikipedia.org/wiki/Sperm-associated_antigen_5

The two centrosomes polymerize tubulin to help form a microtubule spindle apparatus. Motor proteins then push the centrosomes ... With respect to the symmetry of the spindle apparatus during metaphase, an approximately axially symmetric (centered) shape is ... Although centrosomes help organize microtubule assembly, they are not essential for the formation of the spindle apparatus, ... Finally, a third criterion is the location of the central spindle in case of closed pleuromitosis: "extranuclear" (spindle ...

https://en.wikipedia.org/wiki/Mitosis

This spindle apparatus consists of microtubules, microfilaments and a complex network of various proteins. During metaphase, ... the chromosomes line up using the spindle apparatus in the middle of the cell along the equatorial plate. The chromosomes move ... Both require vesicular secretions by the Golgi apparatus for resealing and formation of the cytoskeletal network in addition to ... Prophase is the initial phase when spindle fibers appear that function to move the chromosomes toward opposite poles. ...

https://en.wikipedia.org/wiki/Cleavage_furrow

The spindle apparatus of the second meiotic division appears at the time of ovulation. If no fertilization occurs, the oocyte ...

https://en.wikipedia.org/wiki/Ovulation

During the first division, chromosomes may lag behind and become lost from the spindle apparatus. Extra nuclei are occasionally ... During the second division the extra chromosomes tend to form their own spindle apparatus and divide. Megasporogenesis is ...

https://en.wikipedia.org/wiki/Hypericum_punctatum

... maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11. KIF15 is ... KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with ... Vanneste D, Takagi M, Imamoto N, Vernos I (November 2009). "The role of Hklp2 in the stabilization and maintenance of spindle ... Courtois A, Schuh M, Ellenberg J, Hiiragi T (August 2012). "The transition from meiotic to mitotic spindle assembly is gradual ...

https://en.wikipedia.org/wiki/KIF15

... microtubules and the spindle apparatus". European Journal of Cell Biology. 79 (4): 240-51. doi:10.1078/S0171-9335(04)70027-8. ... During interphase, CKIδ associates with the Golgi Apparatus and appears to regulate the budding of clathrin coated vesicles ... Bingham EW, Farrel HM (June 1974). "Casein kinase from the Golgi apparatus of lactating mammary gland". The Journal of ... and cytoplasm of eukaryotes and additionally in the mitotic spindle in mammalian cells. The family members have the highest ...

https://en.wikipedia.org/wiki/Casein_kinase_1

"Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus". J. ... Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact ... Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR (2002). "AKAP350 at the Golgi apparatus. ... "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6): 2771-81. doi:10.1091/mbc ...

https://en.wikipedia.org/wiki/AKAP9

"Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus". J. ... "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J ...

https://en.wikipedia.org/wiki/TACC3

... sister chromatid adhesion and rearrange the spindle apparatus. During meiosis, there are 2 sets of cell divisions, the second ... and mitotic/meiotic spindle defects that could result in insertions, deletions, abnormal segregation, DNA bridging, and ...

https://en.wikipedia.org/wiki/Meiomitosis

In the first meiotic division, the homologs are segregated to separate daughter cells by the spindle apparatus. The cells then ... Over time the MTOCs merge until two poles have formed, generating a barrel shaped spindle. In human oocytes spindle microtubule ... Unlike mitotic cells, human and mouse oocytes do not have centrosomes to produce the meiotic spindle. In mice, approximately 80 ... The microtubules that make up the spindle network disappear, and a new nuclear membrane surrounds each haploid set. The ...

https://en.wikipedia.org/wiki/Meiosis

CK1δ is involved in the regulation of microtubule polymerization and stability of the spindle apparatus and centrosomes during ... microtubules and the spindle apparatus". European Journal of Cell Biology. 79 (4): 240-51. doi:10.1078/S0171-9335(04)70027-8. ... Roof DM, Meluh PB, Rose MD (July 1992). "Kinesin-related proteins required for assembly of the mitotic spindle". The Journal of ... centrosomes or spindle poles. While the present NLS is not sufficient for nuclear localization of CK1δ, the presence of the ...

https://en.wikipedia.org/wiki/CSNK1D

Spindle checkpoint Kinetochore Spindle apparatus "Examining chromosome-microtubule attachment". Archived from the original on 3 ... Instead, the spindle must actively exert forces on one of the two kinetochores to relocate it to the proper, outer edge of the ... Such attachment errors are common during the early stages of spindle formation, but they are mostly corrected before the start ... During the division process, errors commonly occur in attaching the chromosomes to the spindle, estimated to affect 86 to 90 ...

https://en.wikipedia.org/wiki/Syntelic

During cytokinesis the spindle apparatus partitions and transports duplicated chromatids into the cytoplasm of the separating ... The central spindle (or spindle midzone) forms when non-kinetochore microtubule fibers are bundled between the spindle poles. A ... In short, the self-assembly of central spindle is initiated through the phosphoregulation of multiple central spindle ... where signals from two poles are somehow focused into a ring at the spindle. A second possibility, called the central spindle ...

https://en.wikipedia.org/wiki/Cytokinesis

... was recognized particularly for contributing to discovery of the attachment of chromosomes to the mitotic spindle apparatus. ... Brinkley is attempting to uncover the molecular basis of errors and defects in the nucleus and mitotic apparatus that cause ...

https://en.wikipedia.org/wiki/William_R._Brinkley

Tricellular junctions exert a pulling force on the spindle apparatus and serve as a geometrical clues to determine orientation ... In some Drosophila epithelia, during cell divisions tricellular junctions establish physical contact with spindle apparatus ...

https://en.wikipedia.org/wiki/Cell_junction

During mitosis, clathrin binds to the spindle apparatus, in complex with two other proteins: TACC3 and ch-TOG/CKAP5. Clathrin ... Royle SJ, Bright NA, Lagnado L (April 2005). "Clathrin is required for the function of the mitotic spindle". Nature. 434 (7037 ... August 2013). "Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding". The ... August 2013). "Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding". The ...

https://en.wikipedia.org/wiki/Clathrin

... are properly aligned to the spindle apparatus. Only then, SAC releases its inhibition of the anaphase promoting complex (APC), ... The spindle assembly checkpoint (SAC) is a molecular safe-guarding mechanism that governs proper chromosome segregation in ... Sun, S.-C.; Kim, N.-H. (14 November 2011). "Spindle assembly checkpoint and its regulators in meiosis". Human Reproduction ... The cohesin complex is responsible for keeping together sister chromatids and provides binding sites for spindle attachment. ...

https://en.wikipedia.org/wiki/Nondisjunction

... microtubules gather at opposite poles and begin to form the spindle apparatus at locations called foci. The mitotic spindle is ... The organization of the spindle apparatus is associated instead with foci at opposite poles of the cell or is mediated by ... as the meiotic prophase ends with the spindle apparatus beginning to form, and the nuclear membrane beginning to break down.: ... Plant cells do not have centrosomes and the chromosomes can nucleate microtubule assembly into the mitotic apparatus. In plant ...

https://en.wikipedia.org/wiki/Prophase

Yoshio Masui cell cycle Cdk1 cyclin DNA replication nuclear transport spindle apparatus condensin cohesin Lohka MJ, Masui Y ( ... 1985). "Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts". J. Cell ... it undergoes a series of structural changes and is eventually converted into a set of M phase chromosomes with bipolar spindles ... other than cyclin B is necessary for initiating chromosome segregation Discovery of a mechanism of spindle assembly that ...

https://en.wikipedia.org/wiki/Xenopus_egg_extract

In several site excavations ancient instruments were found, mainly spindle whorls apparatus (malacates), in the remains of some ... On the one hand, they have often been associated with spindle whorls, although there is little ethnographic documentation to ... Its most definite function, more than any of the remaining ceramic artifacts, always considered as spindle whorls. However, as ...

https://en.wikipedia.org/wiki/Ixcateopan_(archaeological_site)

The mechanism of polyploidy induction by noscapine is suggested to involve either chromosome spindle apparatus damage or cell ... Schuler, M.; Muehlbauer, P.; Guzzie, P.; Eastmond, D.A. (1999). "Noscapine hydrochloride disrupts the mitotic spindle in ...

https://en.wikipedia.org/wiki/Noscapine

... forming what is called the spindle apparatus). This allows the microtubules to pull the chromosomes apart in the process of ...

https://en.wikipedia.org/wiki/Strømme_syndrome

The cell is spindle or cigar-shaped, somewhat pointed at the anterior end. It has a pellicle with parallel finely-ridged ... Next to the reservoir, lies Peranema's highly developed feeding apparatus, a cytostomal sac supported on one side by a pair of ... Nisbet, Brenda (February 1974). "An Ultrastructural Study of the Feeding Apparatus of Peranema trichophorum". Journal of ... consuming them with the help of a rigid feeding apparatus called a "rod-organ." Unlike the green euglenids, they lack both an ...

https://en.wikipedia.org/wiki/Peranema

Chaunacidae have been found to contain a specialized apparatus containing adductor muscles that can maintain its ventilatory ... spinosis which has simple as well as bifurcate dermal spindles). They also differ slightly in color. The inside of the mouth, ...

https://en.wikipedia.org/wiki/Sea_toad

U.S. Patent 462,418 - Method of and Apparatus for Electrical Conversion and Distribution - 1891 November 3 - Apparatus devised ... Eccentric weight to a spindle; Rotating terminal connected with spindle; Receptacle mounted to rotate about an axis inclined to ... Apparatus for Producing Ozone - 1896 September 22 - Primarily provides a simple, cheap, and effective apparatus for the ... Improved Process of and Apparatus for Production of High Vacua - 1921 March 24 GB185446 - Method of and Apparatus for Aerial ...

https://en.wikipedia.org/wiki/List_of_Nikola_Tesla_patents

... of which the spindles are made) cannot polymerise. The absence of microtubule attachment to kinetochores activates the spindle ... The perinuclear structural organization of the Golgi apparatus in eukaryotes is dependent on microtubule trafficking, but ... Microscopy of nocodazole-treated cells shows that they do enter mitosis but cannot form metaphase spindles because microtubules ... forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in ...

https://en.wikipedia.org/wiki/Nocodazole

In addition, work from the Kaverina group at Vanderbilt, as well as others, suggests that the Golgi apparatus can serve as an ... They are also involved in cell division (by mitosis and meiosis) and are the main constituents of mitotic spindles, which are ... It that has been shown to interact with γ-TuRC and increase microtubule density around the mitotic spindle origin. Some cell ... Astral microtubules interact with motor proteins at the cell membrane to pull the spindle and the entire cell apart once the ...

https://en.wikipedia.org/wiki/Microtubule

... also the spindle was allowed to slide to and fro endwise under tension of another spring, or weight, to follow the contour on ... Cutting with a fixed or revolving cutter while the work is rotated on a radial or non-radial path and the cutting apparatus ... mounted on the lathe spindle and allowing the headstock to rock under tension of a spring or weight, to follow the contour on ...

https://en.wikipedia.org/wiki/Ornamental_turning

Their interaction is necessary for Kinesin-5 localization to the mitotic spindle, for stabilizing the spindle, and for spindle ... Sawin KE, Mitchison TJ, Wordeman LG (1992). "Evidence for kinesin-related proteins in the mitotic apparatus using peptide ... spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4): 1580-90. doi:10.1091/mbc.E03-07-0544. PMC ... is a homotetramer which cross-links anti-parallel microtubules in the mitotic spindle to maintain spindle bipolarity. The motor ...

https://en.wikipedia.org/wiki/Kinesin-like_protein_KIF11

342, 343 in Light and Movement]. Diagram 1, an overhead view of the apparatus looking down on the horizontally running ... film ran around a series of spindles. The film, with a single row of perforations engaged by an electrically powered sprocket ... "Apparatus for Exhibiting Photographs of Moving Objects" in Mannoni et al., Light and Movement, n.p. Gomery, Douglas (1985). " ... "Apparatus for Exhibiting Photographs of Moving Objects". In the first Kinetograph application, Edison stated, "I have been able ...

https://en.wikipedia.org/wiki/Kinetoscope

... spindle cell melanoma and sarcomatoid squamous cell carcinoma. Urothelial tumors express CD10 (42-67%). CD10 expression is ... the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to ...

https://en.wikipedia.org/wiki/Neprilysin

The spindle of the shock absorber now became the upper suspension pivot, usually double-ended. One of the last mass-production ... Shock absorber U.S. Patent 933,076 Shock Absorbing Apparatus, Issued: September 7, 1909 Wikimedia Commons has media related to ... A lever arm was attached to the axle and inside the cylinder, this rotated a spindle carrying a vane or paddle. This vane had ... This type of shock absorber had a large cast body containing a cylinder and pistons attached to a similar spindle and lever arm ...

https://en.wikipedia.org/wiki/Lever_arm_shock_absorber

There are also artifacts made of wood (instruments, plates), copper (bracelets, weights, macanas), silver (spindles, plates, ... outright opposition to the military regime and the equipping of the University of São Paulo by the repressive state apparatus ...

https://en.wikipedia.org/wiki/Museum_of_Archeology_and_Ethnology_of_the_University_of_São_Paulo

Muscle spindles contain mechanoreceptors that detect stretch in muscles. Somatic sensory receptors near the surface of the skin ... receptor's adequate stimulus is the stimulus modality for which it possesses the adequate sensory transduction apparatus. ... Examples of such tonic receptors are pain receptors, joint capsule, and muscle spindle. A phasic receptor is a sensory receptor ...

https://en.wikipedia.org/wiki/Sensory_neuron

Orgel LE (Dec 1968). "Evolution of the genetic apparatus". Journal of Molecular Biology. 38 (3): 381-93. doi:10.1016/0022-2836( ... Diener TO (Aug 1971). "Potato spindle tuber "virus". IV. A replicating, low molecular weight RNA". Virology. 45 (2): 411-28. ...

https://en.wikipedia.org/wiki/RNA_world

Machines with horizontal spindle ISO 1701-2:2004 Part 2: Machines with vertical spindle ISO 1703:2005 Assembly tools for screws ... 1975 Porcelain laboratory apparatus - Requirements and methods of test ISO 1776:1985 Glass - Resistance to attack by ... Machines with horizontal spindle ISO 1984-2:2001 Part 2: Machines with vertical spindle ISO 1985:2015 Machine tools - Test ... Spindle gauges for ring-spinning and ring-doubling frames ISO/R 95:1972 Textile machinery and accessories - Rings for ring- ...

https://en.wikipedia.org/wiki/List_of_International_Organization_for_Standardization_standards,_1–1999

The HDD's spindle system relies on air density inside the disk enclosure to support the heads at their proper flying height ... July 1976} {US 3,849,800 Magnetic disk apparatus. Cuzner, Dodman, Heath, & Rigbey} Alcorn, Paul (March 19, 2018). "Need A 100TB ... In modern drives, there is one head for each magnetic platter surface on the spindle, mounted on a common arm. An actuator arm ... A typical HDD has two electric motors: a spindle motor that spins the disks and an actuator (motor) that positions the read/ ...

https://en.wikipedia.org/wiki/Hard_disk_drive

The new apparatus is more stable, wider, and longer than the older vaulting horse, approximately 1 m in length and 1 m in width ... moores and spindles) or by straddling their legs (Flares). Routines end when the gymnast performs a dismount, either by ... This apparatus is thus considered safer than the vaulting horse used in the past. With the addition of this new, safer vaulting ... Rope This apparatus may be made of hemp or a synthetic material which retains the qualities of lightness and suppleness. Its ...

https://en.wikipedia.org/wiki/Gymnastics

For example, with a hard and rigid rotor-spindle coated with a thin layer of a softer material (like a polyurethane rubber), a ... The first U.S. patent to disclose a vibrationally-driven motor may be "Method and Apparatus for Delivering Vibratory Energy" (U ... 3,184,842, Maropis, 1965). The Maropis patent describes a "vibratory apparatus wherein longitudinal vibrations in a resonant ...

https://en.wikipedia.org/wiki/Piezoelectric_motor

DELGADO, J. M. R., Johnston, V. S., Wallace, J. D., and Bradley, R. J.: Operant Conditioning of Amygdala Spindling in the Free ... JOHNSTON, V. S. Method and apparatus for generating composites of human faces U.S. Patent # 5,375,195, 1994. WANG, X. T. & ...

https://en.wikipedia.org/wiki/Victor_Johnston

Apparatus norms set by the FIG specify that the beam must be 125 cm (4 ft) high, 500 cm (16 ft) long, and 10 cm (3.9 in) wide. ... "spindles") or by straddling their legs ("flares"). Routines end when the gymnast performs a dismount, either by swinging his ... This new, safer apparatus led gymnasts to attempt more difficult vaults. On the men's side, the gymnasts who have won the most ... Of all gymnastics apparatuses-men's or women's-balance beam has proven the most difficult on which to win multiple Olympic and ...

https://en.wikipedia.org/wiki/Artistic_gymnastics

Mazia's research focused mainly on processes of mitosis , and was the first to isolate a spindle apparatus from a cell ... This discovery ended doubt of what the apparatus looked like, as well as opened a variety of new questions about the makeup of ... He never lost interest in the apparatus, and continued to research it throughout his career. Mazia's doctoral research worked ... research was done in conjunction with Katsuma Dan where they completed the first successful isolation of a mitotic apparatus ...

https://en.wikipedia.org/wiki/Daniel_Mazia

One part of this machine, called an "endless spindle" ("fusee sans fin") and consisting of great mechanical complexity, allowed ... It constituted the world's second publicly demonstrated apparatus for radio control, after Nikola Tesla's Patented " ... Endless Spindle (CS1: Julian-Gregorian uncertainty, CS1 Spanish-language sources (es), CS1 French-language sources (fr), ...

https://en.wikipedia.org/wiki/Leonardo_Torres_y_Quevedo

Chromosomes are contained within these spindles of the centrocone throughout the cell cycle. Brooks CF, Francia ME, Gissot M, ... "A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus". Journal of Cell Science. 119 ( ... Centrocones are located in the nuclear envelope and contain spindles that are used in mitosis. ... spindle pole)". Cellular Microbiology. 16 (1): 78-94. doi:10.1111/cmi.12185. PMC 3933516. PMID 24015880. v t e (Organelles, All ...

https://en.wikipedia.org/wiki/Centrocone

It is involved in establishing the stacked structure of the Golgi apparatus and linking the stacks into larger ribbons in ... Sütterlin C, Polishchuk R, Pecot M, Malhotra V (July 2005). "The Golgi-associated protein GRASP65 regulates spindle dynamics ... "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal ...

https://en.wikipedia.org/wiki/GRASP65

MTA1 localizes to the mitotic spindle apparatus and interacts with TPR in spindle assembly checkpoint regulation.. Liu, Jian; ... we reveal that MTA1 is dynamically localized to the spindle apparatus throughout the entire mitotic process. We also ... and unraveled a novel role of MTA1 in inhibiting spindle damage-induced spindle assembly checkpoint (SAC) activation in cancer ... Further investigation revealed that MTA1 interacts and colocalizes with Translocated Promoter Region (TPR) on spindle ...

https://pesquisa.bvsalud.org/perinatal/resource/pt/mdl-37467663

Spindle Apparatus / physiology * Sumoylation * Transcription, Genetic* * Transplantation, Heterologous * Ubiquitin-Activating ... A subset of these SUMOylation-dependent Myc switchers (SMS genes) is required for mitotic spindle function and to support the ...

https://pubmed.ncbi.nlm.nih.gov/22157079/

SSMISAS - mitotic spindle apparatus signal. Variable Name: SSMISAS. SAS Label: mitotic spindle apparatus signal. English Text: ... SSMISAP - mitotic spindle apparatus positive. Variable Name: SSMISAP. SAS Label: mitotic spindle apparatus positive. English ... Spindle Apparatus The spindle fibers between the poles are stained in mitotic cells, associated with cone-shaped decoration of ... mitotic spindle apparatus signal. Target: Both males and females 12 YEARS - 150 YEARS. Code or Value. Value Description. Count ...

https://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/SSANA_A.htm

Spindle Apparatus 纺锤体 emergency oxygen apparatus 应急供氧装置 ; 紧急供氧装置 ; 应急氧气设备 ; 应急供氧装配 ... apparatus /ˌæpəˈreɪtəs/ CET6 TEM4 * 1. N-VAR The apparatus of an organization or system is its structure and method of ... 名词定义中文名称：器官英文名称：apparatus定义：成对的(单成分)或几种(多成分)类型的分离牙形刺组合的复原。代表一个牙形动物

http://youdao.com/w/eng/apparatus/

In mice, the spindle is predominantly assembled at the oocyte center before its migration toward the cortex to achieve the ... Spindle positioning within the oocyte must be tightly regulated. ... Spindle Apparatus* Actions. * Search in PubMed * Search in MeSH ... Spindle positioning within the oocyte must be tightly regulated. In mice, the spindle is predominantly assembled at the oocyte ... The significance of the initial central positioning of the spindle is largely unknown. We show that initial spindle positioning ...

https://www.ncbi.nlm.nih.gov/pubmed/36800430

Defects in a cell cycle surveillance mechanism called the spindle checkpoint contribute to chromosome instability and ... Spindle Apparatus* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error. ... The spindle checkpoint, aneuploidy, and cancer Rajnish Bharadwaj et al. Oncogene. 2004. . ...

https://pubmed.ncbi.nlm.nih.gov/15021889

MeSH Terms: Humans; Mitosis*; Spindle Apparatus* Back. to Top National Institute of. Environmental Health Sciences. ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3364734

4. Antibody to mitotic spindle apparatus.. Webb J; Maule P; Wells JV. J Rheumatol; 1985 Jun; 12(3):623-4. PubMed ID: 3876438. [ ... 6. Two major autoantigen-antibody systems of the mitotic spindle apparatus.. Andrade LE; Chan EK; Peebles CL; Tan EM. Arthritis ... Anti-mitotic spindle associated antibody].. Obayashi H; Fujinami A; Ohta M. Nihon Rinsho; 2010 Jun; 68 Suppl 6():670-2. PubMed ... Anti-mitotic spindle associated antibody].. Obayashi H; Wada T; Fukui I; Nakayama A. Nihon Rinsho; 1999 Nov; 57 Suppl():528-31 ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=7799375&mod=related&page=1&outid=&proj=

Researchers led by Melina Schuh found a cause for unstable spindles in human oocytes which could lead to therapeutic approaches ... the spindle apparatus - ensures that a maturing oocyte retains the correct number of chromosomes. It consists of spindle fibers ... Unstable spindles due to a missing motor protein. To find out what makes human spindles so unstable, the team compared the ... "We already know that human oocytes frequently assemble spindles with unstable poles. Such unstable spindles misarrange ...

https://www.mpg.de/18248331/0210-bich-A-missing-motor_-causes-our-eggs-to-fail-17216463-x

... studies of the organization and dynamics of structures such as the mitotic spindle and secretory apparatus; and analysis of ...

https://grants.nih.gov/grants/guide/pa-files/PA-98-077.html

Spindle Apparatus Medicine & Life Sciences 100% * Methyltransferases Medicine & Life Sciences 89% * RNA Medicine & Life ... Misu might mediate its function at the spindle by recruiting nucleolar and spindle-associated protein (NuSAP), an essential ... Misu might mediate its function at the spindle by recruiting nucleolar and spindle-associated protein (NuSAP), an essential ... Misu might mediate its function at the spindle by recruiting nucleolar and spindle-associated protein (NuSAP), an essential ...

https://researchportal.bath.ac.uk/en/publications/the-nucleolar-rna-methyltransferase-misu-nsun2-is-required-for-mi

During the metaphase, the spindle apparatus becomes well-defined and the chromosomes get arranged at the equatorial plate. ... mitotic spindle Answer: Answer: centriole. Prophase is the first phase of mitosis. It begins with the division of the centriole ... 2. Equatorial plate of the mitotic spindle is formed during the _______.. anaphase metaphase. late prophase early prophase ...

https://www.syvum.com/cgi/online/serve.cgi/squizzes/biology/mitosis.html?question_hide

... to the genetic material or kinetochores and spindle apparatus. ... of long fibers with mitotic spindle and chromosome migration. ... That is, fibers may directly or indirectly interact with the spindle mechanism involved in chromosomal separation during cell ...

https://www.atsdr.cdc.gov/hac/asbestospanel/appendix_e.html

Non liposomal vincristine sulfate stabilizes the spindle apparatus, preventing chromosome segregation, triggering metaphase ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27dcad60-3a01-48e8-9cf6-46ed03d20bf7

The contributors describe how sister chromatids attach to one another and to the spindle apparatus; how the spindle ... Emergent Properties of the Metaphase Spindle. Simone Reber and Anthony A. Hyman. Chromosome Dynamics during Mitosis. Tatsuya ...

https://www.cshlpress.com/default.tpl?action=full&cart=1570740509180773024&--eqskudatarq=1045&typ=ps&newtitle=Mitosis

Meiotic Spindle Meiotic Spindle Apparatus Mitotic Apparatus Mitotic Spindle Mitotic Spindle Apparatus Spindle Apparatus, ... Mitotic Spindle Apparatus Narrower Concept UI. M0579332. Terms. Mitotic Spindle Apparatus Preferred Term Term UI T026726. Date ... Spindle Apparatus [A11.284.430.214.190.750.820] * Spindle Poles [A11.284.430.214.190.750.820.500] ... It is similar in structure and function to the MITOTIC SPINDLE APPARATUS that forms during MITOSIS.. Terms. Meiotic Spindle ...

https://meshb.nlm.nih.gov/record/ui?ui=D008941

18.5: The Mitotic Spindle The mitotic spindle-or spindle apparatus-is a eukaryotic, cytoskeletal structure made up of long ... For example, kinesin-5 motors at the spindle midzone attach to and slide apart two microtubules extending from opposite spindle ... this process promotes spindle bipolarity and elongation by pushing the spindle poles away from each other. ... Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where ...

https://www.jove.com/science-education/12056/the-mitotic-spindle?language=Spanish

Spindle Apparatus A11.284.430.214.190.750.820.500 Spindle Poles A11.284.430.214.190.750.820.500.500 Centrosome A11.284.430.214. ... Golgi Apparatus A11.284.430.214.190.875.336.850 trans-Golgi Network A11.284.430.214.190.875.393 Lipid Droplets A11.284.430.214. ... Muscle Spindles A08.675.650.915.750.600 Neuroepithelial Cells A08.675.650.915.750.600.350 Hair Cells, Auditory A08.675.650.915. ... Muscle Spindles A08.800.950.750.600 Neuroepithelial Cells A08.800.950.750.600.350 Hair Cells, Auditory A08.800.950.750.600.350. ...

https://www.nlm.nih.gov/mesh/2019/download/2019New_Mesh_Tree_Hierarchy.txt

Spindle Apparatus/metabolism*. *Spindle Apparatus/ultrastructure. *Tubulin/genetics. *Tubulin/metabolism. *Tumor Suppressor ... The cilia protein IFT88 is required for spindle orientation in mitosis. Authors. Delaval, B., Bright, A., Lawson, N.D., and ... Delaval, B., Bright, A., Lawson, N.D., and Doxsey, S. (2011) The cilia protein IFT88 is required for spindle orientation in ... Several IFT proteins also localize to spindle poles in mitosis, indicating uncharacterized functions for these proteins in ...

https://zfin.org/ZDB-PUB-110429-11

2. The spindle support apparatus for a cylindrical workpiece according to claim 1, wherein two of said split liners are ... 8. The spindle support apparatus for cylindrical workpieces of claim 1 wherein the two half-cylinder structures of the split ... 9. The spindle support apparatus for cylindrical workpieces of claim 1 wherein an annular rubber ring is disposed between said ... 1 and the spindle, the friction force generated when the split lining body. 1 and the spindle 10 are clamped can be increased ...

https://patents.google.com/patent/CN107984278B/en

... all three components will be mixed together by the electrically excited spindle of our lightning fast mixing apparatus. It ...

http://franklinfountain.com/july-12/

... one in nuclear transport and another in organizing the chromosome segregation apparatus, called the spindle, during mitosis. ... In mitosis, particularly, we showed that the chromosomes use Ran to orient the spindle. It was a complete change of thinking ... Theyre the reason for the event but not an active participant. Understanding how Ran contributes to spindle assembly changed ... physical relationship between nucleoporins-proteins found at pores around the nucleus-and the mitotic spindle (work published ...

https://www.nichd.nih.gov/newsroom/news/090319-dasso

"The centrosome and mitotic spindle apparatus in cancer and senescence", Cell Cycle, vol. 9, no. 22, pp. 4469-4473, 2010. ...

https://www.uni-ulm.de/nawi/cme/forschung/publikationsverzeichnis/?tx_publications_pi1%5BcurrentPage%5D=9&cHash=8fa8daee69a63038de23335d6e283a01

... similar to the size of microtubules that form the mitotic spindle and may be incorporated into the mitotic spindle apparatus. ... Centrosome fragmentation, mitotic spindle disruption and aneuploidy are characteristics of cancer cells and may lead to an ... Induction of mitotic spindle aberrations by occupationally relevant doses of single-walled carbon nanotubes. ... Our results show significant disruption of the mitotic spindle by SWCNT at occupationally relevant doses. ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=+%27ultrafine%2A%27+OR+%28%27nano%2A%27+AND+%27particle%2A%27%29+OR+%27nanotech%2A%27+OR+%27nanomaterial%2A%27+OR+%27nanoparticle%2A%27+OR+%27nanotube%2A%27+&f1=%2A&Startyear=&terms=3&Adv=1&ct=&B1=Search&Limit=25000&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=155&RecNo=1543&View=f&

Drosophila γ-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus ... Rebollo, E., Sampaio, P., Januschke, J., Llamazares, S., et al. (2007). Functionally Unequal Centrosomes Drive Spindle ...

https://www.ibmc.up.pt/research/publications?s=title&%3Bf%5Bag%5D=C&%3Bf%5Bauthor%5D=2099&o=asc&f%5Bauthor%5D=4590

Heald has done groundbreaking research on the mechanisms of cell division, focusing on the mitotic spindle apparatus, which ... She is using her Pioneer Award to study how cells determine the size of their component organelles, such as the spindle. Heald ...

http://commonfund.nih.gov/pioneer/awardrecipients06

mitotic spindle orientation, H pattern, cell division, cell line, mitosis, mitotic spindle apparatus, microtubules ... Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation ... mitotic spindle orientation, cell microenvironment geometry, cortical cues, spindle pole, symmetric/ asymmetric orientation ... Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL ...

https://cytoo.com/micropattern-products/chips/cytoochips%E2%84%A2-h-s-fn-x18

At later stages, germ plasm masses continue to use components of the cell division machinery, such as the spindles, centrosomes ... Since in each subsequent spindle apparatus covers half the cortex as in the previous one, this predicts the accumulation of ... When spindle microtubules originating from opposing asters overlap at the spindle midzone, they signal furrow formation along ... suggesting that segregation might rely on the spindle apparatus as proposed in Xenopus. germ plasm segregation [92, 99], as ...

https://www.intechopen.com/chapters/49857

Spindle Flyers, Spinning Rings to Canada was 25449 US Dollars. Discover more data with NationMaster! ... Re-Import of Electric Brazing, Soldering Machines and Apparatus Except Soldering Irons and Guns to Canada ... How does Canada rank in Re-Import of Spinning Spindles, Spindle Flyers, Spinning Rings?. #. 5 Countries. US Dollars. Last. YoY ... Since 2014, Canada Re-Import of Spinning Spindles, Spindle Flyers, Spinning Rings jumped by 35.3% year on year. With $25,448.86 ...

https://www.nationmaster.com/nmx/timeseries/canada-re-import-of-spinning-spindles-spindle-flyers-spinning-rings

15. Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations. (nih.gov)
The nanotube bundles are similar to the size of microtubules that form the mitotic spindle and may be incorporated into the mitotic spindle apparatus. (cdc.gov)
It is similar in structure and function to the MITOTIC SPINDLE APPARATUS that forms during MITOSIS. (bvsalud.org)
Application of collagen triple helix repeat containing-1 and mitotic spindle apparatus antibody in small cell lung cancer diagnosis. (bvsalud.org)
This gene encodes a protein associated with the mitotic spindle apparatus. (utsouthwestern.edu)

The mitotic spindle-or spindle apparatus-is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. (jove.com)
It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules. (bvsalud.org)
Chromosome attachment to spindle microtubules (MTs) is mediated by kinetochores, which are large multiprotein complexes assembled on centromeres located at the constriction point of sister chromatids. (pberghei.eu)
Its most fundamental function is to connect centromeric DNA to dynamic spindle microtubules. (ox.ac.uk)
During metaphase it inhibits the assemblage of microtubules hence spindle formation does not occur. (github.io)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
Here we summarize the most recent advancements made towards understanding kinesin functions in the dynamic organization of microtubule arrays, including cortical microtubules and mitotic pre-prophase band, spindle apparatus and phragmoplast, and the regulation of plant physiological activities. (chinbullbotany.com)

Finally, they are arranged at the opposite poles of the spindle. (syvum.com)
Several IFT proteins also localize to spindle poles in mitosis, indicating uncharacterized functions for these proteins in dividing cells. (zfin.org)
In mitosis, IFT88 is part of a dynein1-driven complex that transports peripheral microtubule clusters containing microtubule-nucleating proteins to spindle poles to ensure proper formation of astral microtubule arrays and thus proper spindle orientation. (zfin.org)
To investigate mitotic spindle aberrations at concentrations anticipated in exposed workers, primary and immortalized human airway epithelial cells were exposed to SWCNT for 24-72 hours.We have now demonstrated fragmented centrosomes, multiple mitotic spindle poles and aneuploid chromosome number at doses equivalent to the permissible exposure limit. (cdc.gov)
Each sister chromatid has its own kinetochore, oriented to facilitate movement to opposite poles of the spindle apparatus. (pberghei.eu)
A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. (mc1-r.com)

Our results show significant disruption of the mitotic spindle by SWCNT at occupationally relevant doses. (cdc.gov)
Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)

Centromere -- The constricted region of a nuclear chromosome, to which the spindle fibers, the microtubule apparatuses that control chromosome movement during mitosis and meiosis, attach during division. (nih.gov)
The alkaloid drug, colchicine, extracted from the corm of the autumn crocus (Colchicum autumnale), arrests mitosis in metaphase by interfering with the formation of spindle fibrils, thereby retarding the division of the centromeres and preventing division of the centrioles. (github.io)
During mitosis it does not interfere with the replication of chromosome but prevents the formation of spindle fibres. (github.io)

hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo. (mc1-r.com)
This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. (nih.gov)

These results indicates that kinetochores establish connection with spindle from the beginning of endomitosis and maintain the connection throughout endomitosis. (pberghei.eu)
In addition, the EB1-decorated spindle MTs are associated laterally with kinetochores ( see below). (pberghei.eu)

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. (jove.com)
During anaphase, the spindle elongates and the sister chromatids separate, resulting in segregation of the two genomes during telophase. (pberghei.eu)

The low density and small size of these biologically persistent particles makes respiratory exposures to workers likely during the production or use of commercial products.We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to 96, 48 and 24 micrograms/centimeter squared single-walled carbon nanotube s (SWCNT). (cdc.gov)

The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. (utsouthwestern.edu)

Centrosome fragmentation, mitotic spindle disruption and aneuploidy are characteristics of cancer cells and may lead to an increased risk of cancer. (cdc.gov)

During the metaphase, the spindle apparatus becomes well-defined and the chromosomes get arranged at the equatorial plate. (syvum.com)
At concentrations of 0.1-1 ug/ml colchicine, a natural plant product, can cause the mitotic arrest of dividing cells at metaphase through disrupting the spindle apparatus. (github.io)
Colchicines prevent spindle formation during mitotic metaphase. (github.io)

At later stages, germ plasm masses continue to use components of the cell division machinery, such as the spindles, centrosomes, and/or subcellular organelles to segregate asymmetrically during cell division and subsequently induce germ cell fate. (intechopen.com)

Actin filaments (F-actin) are linear polymers of globular actin (G-actin) subunits and occur as microfilaments in the cytoskeleton and as thin filaments, which are part of the contractile apparatus, in muscle and nonmuscle cells (see contractile bundles). (mechanobio.info)

The apparatus consists of a stainless steel shaft fixed in a rectangular frame. (qualityengineers.co.in)

The NDC80 complex is the major component of the kinetochore and mediates its attachment to spindle MTs. (pberghei.eu)
Leading Manufacturer of epicyclic gear train apparatus, static and dynamic balancing apparatus, coriollis component of acceleration apparatus, michell tilting pad bearing apparatus, slip and creep measurement apparatus and digital compression testing machine from Ambala. (qualityengineers.co.in)
The set-up is designed to study Coriollis Component of Acceleration Apparatus of a slider crank mechanism. (qualityengineers.co.in)

Similarly as Ndc80, the SPC24, SPC25, and AKiT1 displayed lateral localization to spindle MTs throughout the endomitosis (of male gamete formation) via IFA and U-ExM analysis. (pberghei.eu)

Owing to our domain expertise and the assistance of a dedicated workforce, we are engaged in offering best quality Static and Dynamic Balancing Apparatus at the most affordable market price. (qualityengineers.co.in)

The present disclosure relates to an apparatus and method for holographic recording and reproducing. (justia.com)
It is desirable to provide an apparatus and method for holographic recording and reproducing, the apparatus and method capable of increasing the amount of data recorded on a holographic recording medium. (justia.com)

Recently, attention has been given to holographic memories, serving as recording and reproducing apparatuses capable of achieving high recording density, recording data at high transfer rate, and reproducing recorded data at high rate. (justia.com)
When recorded data is reproduced from a hologram recorded by a holographic recording and reproducing apparatus, shift selectivity is very narrow. (justia.com)

These include several splicing factors for which knockdown generates mitotic spindle defects. (nih.gov)

The quality controllers rigorously check the apparatus on the in-house quality check points. (qualityengineers.co.in)

This apparatus is manufactured from high quality raw material, which is procured from high known vendors. (qualityengineers.co.in)

It has been proposed that the APC/C might fulfil other functions, including assembly of the mitotic spindle. (nih.gov)
A member of the National Academy of Sciences, she is recognized for her work on biological size control and her use of cytoplasmic extracts prepared from eggs of the African clawed frog Xenopus laevis to study how the mitotic spindle forms and scales to different sizes. (nih.gov)
[ 22 ] RHAMM protein is associated with the formation of the mitotic spindle apparatus. (medscape.com)
1. Uncommon patterns of antinuclear antibodies recognizing mitotic spindle apparatus antigens and clinical associations. (nih.gov)
2. Anti-Mitotic Spindle Apparatus Antoantibodies: Prevalence and Disease Association in Chinese Population. (nih.gov)
3. [Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]. (nih.gov)
6. Autoantibodies to mitotic apparatus: association with other autoantibodies and their clinical significance. (nih.gov)
7. The clinical associations of mitotic spindle autoantibodies in a South Australian cohort. (nih.gov)
12. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. (nih.gov)
15. [Detection of autoantibody to mitotic spindle associated antigen (MSA) in sera from patients with positive mycoplasma pneumoniae particle agglutination (PA) test]. (nih.gov)
17. Two major autoantigen-antibody systems of the mitotic spindle apparatus. (nih.gov)
After 24 hr of exposure to either SWCNT or vanadium pentoxide, fragmented centrosomes, multiple mitotic spindle poles, anaphase bridges, and aneuploid chromosome number were observed. (cdc.gov)
Our results are the first to report disruption of the mitotic spindle by SWCNT. (cdc.gov)
The nanotube bundles are similar to the size of microtubules that form the mitotic spindle and may be incorporated into the mitotic spindle apparatus. (cdc.gov)
Heald has done groundbreaking research on the mechanisms of cell division, focusing on the mitotic spindle apparatus, which functions to segregate duplicated chromosomes equally to the two daughter cells. (nih.gov)
It is similar in structure and function to the MITOTIC SPINDLE APPARATUS that forms during MITOSIS . (nih.gov)

She is using her Pioneer Award to study how cells determine the size of their component organelles, such as the spindle. (nih.gov)

Anatomy14

Organisms1

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes20

Information Science2

Drosophila oogenesis: versatile spn doctors. (1/4092)

C-myc overexpression and p53 loss cooperate to promote genomic instability. (2/4092)

Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. (3/4092)

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. (4/4092)

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. (5/4092)

Influence of centriole behavior on the first spindle formation in zygotes of the brown alga Fucus distichus (Fucales, Phaeophyceae). (6/4092)

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice. (7/4092)

Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. (8/4092)

Spindle Apparatus

Nuclear Matrix-Associated Proteins

Mitosis

Microtubules

Centrosome

Chromosome Segregation

Tubulin

Meiosis

Muscle Spindles

Golgi Apparatus

Cell Cycle Proteins

Fluorescent Antibody Technique

HeLa Cells

Molecular Sequence Data

Anaphase

Kinetochores

Metaphase

Kinesin

Microtubule-Associated Proteins

Nocodazole

Mad2 Proteins

Aurora Kinases

Chromosomes

Dyneins

Telophase

M Phase Cell Cycle Checkpoints

Cytokinesis

Microscopy, Fluorescence

Oocytes

Protein-Serine-Threonine Kinases

Microtubule-Organizing Center

Saccharomyces cerevisiae Proteins

Microtubule Proteins

Mutation

Microscopy, Electron

Nuclear Proteins

Motor Neurons, Gamma

Centrioles

Cell Cycle

Prophase

Saccharomyces cerevisiae

Prometaphase

Organoids

Centromere

Cell Polarity

Birefringence

Protein Transport

Cdc20 Proteins

ran GTP-Binding Protein

Amino Acid Sequence

Interphase

Xenopus Proteins

Drosophila oogenesis: versatile spn doctors. (1/4092)

C-myc overexpression and p53 loss cooperate to promote genomic instability. (2/4092)

Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. (3/4092)

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. (4/4092)

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. (5/4092)

Influence of centriole behavior on the first spindle formation in zygotes of the brown alga Fucus distichus (Fucales, Phaeophyceae). (6/4092)

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice. (7/4092)

Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. (8/4092)

Spindle apparatus

Glossary of genetics (M−Z)

ParABS system

Parvulin 14

Hertwig rule

Glossary of genetics

Melina Schuh

Teuthowenia megalops

Sperm-associated antigen 5

Mitosis

Cleavage furrow

Ovulation

Hypericum punctatum

KIF15

Casein kinase 1

AKAP9

TACC3

Meiomitosis

Meiosis

CSNK1D

apparatus】什么意思英语apparatus的翻译音标读音用法例句在线翻译