Spinal Cord Vascular Diseases
Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD, such as the anterior and paired posterior spinal arteries or their many branches. Disease processes may include ATHEROSCLEROSIS; EMBOLISM; and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia).
Spinal Cord
Spinal Cord Injuries
Vascular Diseases
Spinal Cord Diseases
Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Peripheral spinal cord hypointensity on T2-weighted MR images: a reliable imaging sign of venous hypertensive myelopathy. (1/17)
BACKGROUND AND PURPOSE: MR findings reported in conjunction with spinal dural arteriovenous fistula (SDAVF) include cord swelling, increased T2 signal within the spinal cord, and parenchymal enhancement, each of which is nonspecific. Enlarged vessels on the cord surface, the most specific MR finding, is noted in only half of SDAVF patients. Nevertheless, we have frequently observed MR peripheral hypointensity of the spinal cord in SDAVF on T2-weighted images, which is not characteristic of nonvascular or nonhemorrhagic causes of myelopathy and which has not been described in association with SDAVF. We hypothesized that peripheral cord hypointensity might reliably suggest the diagnosis of SDAVF or other causes of venous hypertensive myelopathy. METHODS: We reviewed the MR findings in 11 consecutive cases of angiographically confirmed symptomatic SDAVF and in four cases of intracranial dural arteriovenous fistula with spinal drainage, a lesion that also causes spinal cord deficits mediated by venous hypertensive myelopathy. RESULTS: In each case, T2 hypointensity involving the cord periphery was present. This sign has not been previously described in association with either SDAVF or other causes of venous hypertensive myelopathy. It appears, however, to be a relatively constant imaging feature of SDAVF. CONCLUSION: In the absence of spinal hemorrhage, T2 hypointensity involving the periphery of the spinal cord suggests venous hypertensive myelopathy as a cause of spinal cord dysfunction. (+info)Neurovascular complications of marfan syndrome: a retrospective, hospital-based study. (2/17)
BACKGROUND AND PURPOSE: Small case series have associated Marfan syndrome with cerebral and spinal ischemia or hemorrhage. However, there has been no investigation of the frequency and etiology of neurovascular disorders in a large series of Marfan patients. METHODS: We conducted a retrospective, hospital-based study of all Marfan syndrome patients seen in an 8-year period. Records were reviewed in detail, and clinical characteristics of those with and without a neurovascular diagnosis compared. RESULTS: Of 513 patients, 18 (3.5%) had a neurovascular diagnosis, as follows: transient ischemic attack (11), cerebral infarction (2), spinal cord infarction (2), subdural hematoma (2), and spinal subarachnoid hemorrhage (1). A cardioembolic source was identified in 12 of 13 patients with cerebral ischemia, as follows: prosthetic heart valves (9), mitral valve prolapse (2), and atrial fibrillation (1). Chronic anticoagulant therapy was a likely cause in 2 of 3 patients with hemorrhagic events. Compared with other Marfan syndrome patients, those with neurovascular events were older (39.6 versus 31.7 years, P=0.04) and more likely to be in atrial fibrillation (22.2% versus 3.2%, P=<0.01), to have prosthetic heart valves (61.1% versus 7.7%, P=0.001), and to be taking anticoagulant therapy (72.2% versus 16.1%, P<0.001). Aortic disease, a putative factor in the etiology of neurovascular complications, was present in equal measure in Marfan patients with and without neurovascular complications (78% versus 65%, P=NS). CONCLUSIONS: Neurovascular complications of Marfan syndrome are rare during 8 years of follow-up, and generally are ischemic in nature. A high-risk cardiac source was identified in the majority. A significant association with vascular dissection was not established. (+info)Spinal tanycytic ependymoma with hematomyelia--case report--. (3/17)
A 58-year-old man presented with an extremely rare case of "pure type" spinal tanycytic ependymoma associated with hematomyelia manifesting as sensory disturbance of the bilateral hands and weakness of the right arm. Magnetic resonance imaging demonstrated a tumor in the spinal cord from C-2 to C-4 levels. The soft gelatinous tumor was subtotally resected and the adjacent chronic liquid hematoma was aspirated. The immunohistochemical and ultrastructural findings indicated a diagnosis of tanycytic ependymoma. (+info)Transient traumatic spinal venous hypertensive myelopathy. (4/17)
We present a case of a reversible spinal venous hypertensive myelopathy that occurred following a traumatic mediastinal hematoma. The mediastinal hematoma caused compression of the brachiocephalic vein, resulting in elevation of the venous pressures that ultimately resulted in dilation of the epidural venous plexus and spinal cord edema. The secondary neurologic deficits were the culmination of venous outflow obstruction at the level of the spinal cord that resolved on the resolution of the mediastinal hematoma. (+info)Usefulness of combined electrophysiological examinations for detection of neural dysfunction in cats with lumbar hematomyelia. (5/17)
We conducted combined electrophysiological examinations including F-wave, motor nerve conduction velocity (MNCV), spinal cord-evoked potential (SCEP), and needle electromyography (EMG) in two cats involved in traffic accidents that consequently developed hind limb paralysis caused by lumbar hematomyelia. F-wave could no longer be elicited within 3 days after the accident, and the MNCV and compound muscle action potential (CMAP) amplitude decreased in a time-dependent manner, with CMAP no longer being evoked after 7 or 8 days. EMG showed abnormalities such as fibrillation and positive sharp waves after 6 to 8 days. These results suggest that such combined electrophysiological examinations may provide objective, quantitative data for motor nerve dysfunction in cats with lumbar hematomyelia. (+info)Spinal arteriovenous shunts presenting as intracranial subarachnoid haemorrhage. (6/17)
BACKGROUND: In approximately 5% of patients with intracranial subarachnoid haemorrhage (SAH), the cause is another than a ruptured aneurysm or perimesencephalic haemorrhage. One of these causes is a spinal arteriovenous shunt (SAVS). The aim of this study was to investigate the characteristics of patients with SAVS who present with intracranial SAH without symptoms and signs suggesting a spinal cause. METHODS: We systematically reviewed the literature and searched the SAH database of the University Medical Center Utrecht, The Netherlands, for patients with SAVS presenting with intracranial SAH and studied the characteristics of patients with SAVS whose clinical presentation mimicked intracranial SAH caused by rupture of a saccular aneurysm. RESULTS: Thirty-five patients were identified after a review of the literature. In our SAH database, comprising 2142 patients included in the period 1985-2004, we found one patient (0.05%, 95 % CI 0.006- 0.3%). SAH due to SAVS occurred at any age (4-72 years). The SAVS was located at the craniocervical junction in 14 patients, at the cervical level in 11, and at the thoracolumbar level in the remaining 11 patients. The majority of patients (n = 26, 72%) had no disabling deficits at discharge or follow-up. CONCLUSION: Rupture of a SAVS presenting as intracranial SAH is rare and can occur at any age. The SAVS can be located not only at the craniocervical junction or cervical level but also in the thoracolumbar region. Most patients with SAVS presenting as intracranial SAH have a good recovery. (+info)Hematomyelia caused by ruptured intramedullary spinal artery aneurysm associated with extramedullary spinal arteriovenous fistula--case report. (7/17)
A 53-year-old woman presented with a ruptured intramedullary aneurysmal dilatation fed by the anterior spinal artery associated with an arteriovenous malformation located in the ventral cervical spinal cord. She developed tetraparesis and respiratory dysfunction. The neurological deterioration was caused by hematomyelia due to the ruptured aneurysmal dilatation and progression of edema in the upper cervical spinal cord due to venous hypertension associated with additional hematoma in the medulla oblongata. Endovascular embolization of both C-1 and C-2 radicular arteries was performed with Guglielmi detachable coils, but components fed by small branches such as the radiculo-pial artery were not obliterated. Surgery was performed for extirpation of the arteriovenous malformation and cervical intramedullary hematoma, and excision of the aneurysmal dilatation through a transcondylar approach combined with vertebral artery transposition. Postoperatively, she overcame several complications such as pneumonia and endocarditis, and had only moderate weakness of the right upper and lower limbs. This case indicates that surgical intervention for high cervical intramedullary lesion may be very effective. (+info)Intramedullary cavernoma presenting with hematomyelia: report of two girls. (8/17)
(+info)Spinal Cord Vascular Diseases refer to conditions affecting the blood vessels of the spinal cord, including ischemia, infarction, and hemorrhage, which can lead to various neurological deficits depending on the severity and location of the vascular damage.
Spinal cord vascular diseases refer to a group of disorders that affect the blood vessels of the spinal cord. These conditions can result in insufficient blood supply to the spinal cord tissue, leading to ischemia (lack of oxygen) and infarction (tissue death). There are several types of spinal cord vascular diseases, including:
1. Spinal Cord Infarction: This is a rare condition that occurs due to the blockage or narrowing of the arteries supplying blood to the spinal cord. It can result in sudden onset of weakness, numbness, or paralysis in parts of the body served by the affected spinal cord region.
2. Spinal Cord Aneurysm: This is a localized dilation or bulging of a weakened area in the wall of a blood vessel that supplies the spinal cord. If an aneurysm ruptures, it can cause bleeding into the spinal cord tissue, leading to neurological deficits.
3. Spinal Cord Arteriovenous Malformations (AVMs): These are abnormal connections between the arteries and veins in the spinal cord. AVMs can lead to bleeding, ischemia, or both, resulting in various neurological symptoms.
4. Spinal Cord Dural Arteriovenous Fistulas (dAVFs): These are abnormal communications between the spinal artery and a vein located outside the dura mater (the protective covering of the spinal cord). dAVFs can cause venous congestion, leading to ischemia and neurological dysfunction.
5. Spinal Cord Vasculitis: This is an inflammation of the blood vessels in the spinal cord, which can lead to narrowing or blockage of the affected vessels. It can result in various neurological symptoms, such as weakness, numbness, or pain.
Treatment for spinal cord vascular diseases depends on the specific condition and its severity. Treatment options may include medications, surgery, endovascular procedures, or a combination of these approaches.
The spinal cord is a major part of the central nervous system, consisting of a thick bundle of nerve fibers and associated tissue that extends from the brainstem to the lower back, transmitting signals between the brain and the rest of the body for motor control, sensory perception, and autonomic functions.
The spinal cord is a major part of the nervous system, extending from the brainstem and continuing down to the lower back. It is a slender, tubular bundle of nerve fibers (axons) and support cells (glial cells) that carries signals between the brain and the rest of the body. The spinal cord primarily serves as a conduit for motor information, which travels from the brain to the muscles, and sensory information, which travels from the body to the brain. It also contains neurons that can independently process and respond to information within the spinal cord without direct input from the brain.
The spinal cord is protected by the bony vertebral column (spine) and is divided into 31 segments: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each segment corresponds to a specific region of the body and gives rise to pairs of spinal nerves that exit through the intervertebral foramina at each level.
The spinal cord is responsible for several vital functions, including:
1. Reflexes: Simple reflex actions, such as the withdrawal reflex when touching a hot surface, are mediated by the spinal cord without involving the brain.
2. Muscle control: The spinal cord carries motor signals from the brain to the muscles, enabling voluntary movement and muscle tone regulation.
3. Sensory perception: The spinal cord transmits sensory information, such as touch, temperature, pain, and vibration, from the body to the brain for processing and awareness.
4. Autonomic functions: The sympathetic and parasympathetic divisions of the autonomic nervous system originate in the thoracolumbar and sacral regions of the spinal cord, respectively, controlling involuntary physiological responses like heart rate, blood pressure, digestion, and respiration.
Damage to the spinal cord can result in various degrees of paralysis or loss of sensation below the level of injury, depending on the severity and location of the damage.
"Spinal cord injuries refer to damage to the spinal cord's nerve fibers, which can result in loss of muscle function, sensation, or autonomic nervous system regulation below the level of injury."
Spinal cord injuries (SCI) refer to damage to the spinal cord that results in a loss of function, such as mobility or feeling. This injury can be caused by direct trauma to the spine or by indirect damage resulting from disease or degeneration of surrounding bones, tissues, or blood vessels. The location and severity of the injury on the spinal cord will determine which parts of the body are affected and to what extent.
The effects of SCI can range from mild sensory changes to severe paralysis, including loss of motor function, autonomic dysfunction, and possible changes in sensation, strength, and reflexes below the level of injury. These injuries are typically classified as complete or incomplete, depending on whether there is any remaining function below the level of injury.
Immediate medical attention is crucial for spinal cord injuries to prevent further damage and improve the chances of recovery. Treatment usually involves immobilization of the spine, medications to reduce swelling and pressure, surgery to stabilize the spine, and rehabilitation to help regain lost function. Despite advances in treatment, SCI can have a significant impact on a person's quality of life and ability to perform daily activities.
'Vascular diseases' is a broad term referring to medical conditions affecting the blood vessels, including their structure, function, or circulation, encompassing arteries, veins, and capillaries, with examples such as peripheral artery disease, venous insufficiency, varicose veins, carotid artery stenosis, and aneurysms.
Vascular diseases are medical conditions that affect the circulatory system, specifically the blood vessels (arteries, veins, and capillaries). These diseases can include conditions such as:
1. Atherosclerosis: The buildup of fats, cholesterol, and other substances in and on the walls of the arteries, which can restrict blood flow.
2. Peripheral Artery Disease (PAD): A condition caused by atherosclerosis where there is narrowing or blockage of the peripheral arteries, most commonly in the legs. This can lead to pain, numbness, and cramping.
3. Coronary Artery Disease (CAD): Atherosclerosis of the coronary arteries that supply blood to the heart muscle. This can lead to chest pain, shortness of breath, or a heart attack.
4. Carotid Artery Disease: Atherosclerosis of the carotid arteries in the neck that supply blood to the brain. This can increase the risk of stroke.
5. Cerebrovascular Disease: Conditions that affect blood flow to the brain, including stroke and transient ischemic attack (TIA or "mini-stroke").
6. Aneurysm: A weakened area in the wall of a blood vessel that causes it to bulge outward and potentially rupture.
7. Deep Vein Thrombosis (DVT): A blood clot that forms in the deep veins, usually in the legs, which can cause pain, swelling, and increased risk of pulmonary embolism if the clot travels to the lungs.
8. Varicose Veins: Swollen, twisted, and often painful veins that have filled with an abnormal collection of blood, usually appearing in the legs.
9. Vasculitis: Inflammation of the blood vessels, which can cause damage and narrowing, leading to reduced blood flow.
10. Raynaud's Phenomenon: A condition where the small arteries that supply blood to the skin become narrowed, causing decreased blood flow, typically in response to cold temperatures or stress.
These are just a few examples of vascular conditions that fall under the umbrella term "cerebrovascular disease." Early diagnosis and treatment can significantly improve outcomes for many of these conditions.
'Spinal cord diseases' refer to a group of medical conditions that affect the spinal cord's structure, function, or both, leading to various neurological symptoms such as pain, sensory loss, motor dysfunction, and autonomic disturbances.
Spinal cord diseases refer to a group of conditions that affect the spinal cord, which is a part of the central nervous system responsible for transmitting messages between the brain and the rest of the body. These diseases can cause damage to the spinal cord, leading to various symptoms such as muscle weakness, numbness, pain, bladder and bowel dysfunction, and difficulty with movement and coordination.
Spinal cord diseases can be congenital or acquired, and they can result from a variety of causes, including infections, injuries, tumors, degenerative conditions, autoimmune disorders, and genetic factors. Some examples of spinal cord diseases include multiple sclerosis, spina bifida, spinal cord injury, herniated discs, spinal stenosis, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).
The treatment for spinal cord diseases varies depending on the underlying cause and severity of the condition. Treatment options may include medication, physical therapy, surgery, and rehabilitation. In some cases, the damage to the spinal cord may be irreversible, leading to permanent disability or paralysis.
Spinal cord compression is a pathological condition characterized by compromised integrity and function of the spinal cord due to direct pressure or indirect injury from surrounding tissues, bone elements, or neoplastic growths within or outside the spinal canal.
Spinal cord compression is a medical condition that refers to the narrowing of the spinal canal, which puts pressure on the spinal cord and the nerves that branch out from it. This can occur due to various reasons such as degenerative changes in the spine, herniated discs, bone spurs, tumors, or fractures. The compression can lead to a range of symptoms including pain, numbness, tingling, weakness, or loss of bladder and bowel control. In severe cases, it can cause paralysis. Treatment options depend on the underlying cause and may include physical therapy, medication, surgery, or radiation therapy.
Spinal Cord Neoplasms are defined as abnormal growths or tumors that develop within the spinal cord or its surrounding structures, which can be benign or malignant, and have the potential to cause various neurological deficits depending on their location and size.
Spinal cord neoplasms refer to abnormal growths or tumors within the spinal cord. These can be benign (non-cancerous) or malignant (cancerous). They originate from the cells within the spinal cord itself (primary tumors), or they may spread to the spinal cord from other parts of the body (metastatic tumors). Spinal cord neoplasms can cause various symptoms depending on their location and size, including back pain, neurological deficits, and even paralysis. Treatment options include surgery, radiation therapy, and chemotherapy.
Peripheral Vascular Diseases (PVD) are a group of disorders affecting the blood vessels outside of the heart and brain, characterized by the narrowing or blockage of arteries due to atherosclerosis, thrombosis, embolism, or inflammation, leading to impaired blood flow, ischemia, and potential tissue damage in the extremities, often resulting in pain, cramps, wounds, or gangrene.
Peripheral Vascular Diseases (PVD) refer to a group of medical conditions that affect the blood vessels outside of the heart and brain. These diseases are characterized by a narrowing or blockage of the peripheral arteries, which can lead to reduced blood flow to the limbs, particularly the legs.
The primary cause of PVD is atherosclerosis, a buildup of fats, cholesterol, and other substances in and on the walls of the arteries, forming plaques that restrict blood flow. Other risk factors include smoking, diabetes, hypertension, high cholesterol levels, and a family history of vascular disease.
Symptoms of PVD can vary depending on the severity of the condition but may include leg pain or cramping during exercise (claudication), numbness or tingling in the legs, coldness or discoloration of the feet, sores or wounds that heal slowly or not at all, and in severe cases, gangrene.
PVD can increase the risk of heart attack and stroke, so it is essential to diagnose and treat the condition as early as possible. Treatment options include lifestyle changes such as quitting smoking, exercising regularly, and maintaining a healthy diet, medications to control symptoms and reduce the risk of complications, and surgical procedures such as angioplasty or bypass surgery to restore blood flow.
Peter Staats
Erdek MA, Staats PS (2003). "Spinal cord stimulation for angina pectoris and peripheral vascular disease". Anesthesiol Clin ...
Spinal cord injury
SCI may occur in intervertebral disc disease, and spinal cord vascular disease. Spontaneous bleeding can occur within or ... A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms ... Anterior spinal artery syndrome also known as anterior spinal cord syndrome, due to damage to the front portion of the spinal ... At each level of the spinal column, spinal nerves branch off from either side of the spinal cord and exit between a pair of ...
Surfer's myelopathy
Acton, Ashton (2012-12-26). Spinal Cord Vascular Diseases-Advances in Research and Treatment: 2012 Edition: ScholarlyPaper. ... such as the anterior spinal artery, can become kinked, depriving the spinal cord of oxygen. Although the condition derives its ... Surfer's myelopathy is a rare, nontraumatic spinal cord injury caused by hyperextension of the back injury and resulting in ... Rehabilitation in spinal cord injury Hawkes, Christopher H.; Sethi, Kapil D.; Swift, Thomas R. (2016-03-29). Instant ...
Spinal cord stroke
Vuong, Shawn M.; Jeong, William J.; Morales, Humberto; Abruzzo, Todd A. (2016-10-01). "Vascular Diseases of the Spinal Cord: ... Unlike anterior spinal cord stroke, motor functions are not handicapped in posterior spinal cord stroke. In central spinal cord ... Spinal cord stroke is a rare type of stroke with compromised blood flow to any region of spinal cord owing to occlusion or ... It is possible that spinal cord ischaemia patients have a full recovery. Although the mortality rate after spinal cord ...
Neuro-Behçet's disease
As for the spinal cord involvement, pyramidal signs in the limbs, sensory level dysfunction, and, commonly, sphincter ... Because Non-parenchymal NBD targets vascular structures, the symptoms arise in the same area. The main clinical characteristic ... A related disorder to Neuro-Behçet's disease is neuro-Sweet disease. Sweet disease (or acute febrile neutrophilic dermatosis) ... The target areas of parenchymal NBD include brainstem, spinal cord, and cerebral regions. Sometimes it is hard to determine the ...
Neurosyphilis
It may present as stroke or spinal cord infarct. Signs and symptoms vary with vascular territory involved. The middle cerebral ... Lumbar puncture ("spinal tap") is used to acquire CSF. The Venereal Disease Research Laboratory test of the CSF is the ... Tabes dorsalis thought to be due to irreversible degeneration of nerve fibers in posterior columns of the spinal cord involving ... The extension of cellular immune response to the brainstem and spinal cord causes inflammation and necrosis of small meningeal ...
Ion N. Petrovici
Petrovici authored Vascular Diseases of the Brain and of the Spinal Cord in 1965. In 1969, he emigrated to Germany and began ... Petrovici published numerous papers on cerebrovascular disease, seizure disorders, therapy of the malignant brain tumours, ...
Sexual dysfunction
Diseases such as cardiovascular disease, multiple sclerosis, kidney failure, vascular disease, and spinal cord injury can cause ... ED from vascular disease is seen mainly amongst older individuals who have atherosclerosis. Vascular disease is common in ... as in sexual dysfunction after spinal cord injuries). Diseases such as diabetic neuropathy, multiple sclerosis, tumors, and, ... peripheral vascular disease, or hypertension. Any time blood flow to the penis is impaired, ED can occur. Drugs are also a ...
Familial Danish dementia
... and the spinal cord. "ADan amyloidosis - About the Disease". rarediseases.info.nih.gov. Retrieved 22 July 2023. Paul, Robert H ... ISBN 978-0-19-973196-1. Wahlund, Lars-Olof; Erkinjuntti, Timo; Gauthier, Serge (2009-02-12). Vascular Cognitive Impairment in ... ADan causes amyloid angiopathy in the cerebrum, choroid plexus, cerebellum, spinal cord, and retinas. Mutations in Cystatin C ... Differential diagnosis includes Begger syndrome and Refsum disease. Most people with this condition die when they reach their ...
Hemangioblastoma
Sometimes, these tumors occur in other sites such as the spinal cord and retina. They may be associated with other diseases ... Hemangioblastomas, or haemangioblastomas, are vascular tumors of the central nervous system that originate from the vascular ... brainstem or spinal cord. They are classed as grade I tumors under the World Health Organization's classification system. ... the brain stem or the spinal cord. Micrograph of cerebellar hemangioblastoma. HPS stain. Micrograph of cerebellar ...
Vascular myelopathy
... (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood ... "Vascular myelopathies-vascular malformations of the spinal cord: presentation and endovascular surgical management". Semin ... The anterior spinal artery has a less efficient supply of blood and is therefore more susceptible to vascular disease. Whilst ... Both the posterior and anterior spinal arteries run the entire length of the spinal cord and receive anastomotic (conjoined) ...
Adult stem cell
CD34+ hematopoietic Stem Cells have been clinically applied to treat various diseases including spinal cord injury, liver ... cirrhosis and Peripheral Vascular disease. Research has shown that CD34+ hematopoietic Stem Cells are relatively more numerous ... 5 July 2012). "Index of CD34+ Cells and Mononuclear Cells in the Bone Marrow of Spinal Cord Injury Patients of Different Age ... 2010). "Multiple injections of in vitro expanded autologous bone marrow stem cells for cervical level spinal cord injury - a ...
CD34
Injection of CD34+ hematopoietic stem cells has been clinically applied to treat various diseases including spinal cord injury ... liver cirrhosis and peripheral vascular disease. CD34 has been shown to interact with CRKL. It also interacts with L-selectin, ... "Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ...
Myelopathy
Disease that is vascular in nature is known as vascular myelopathy. In Asian populations, spinal cord compression often occurs ... spinal stenosis) ultimately causing compression of the spinal cord. When due to trauma, myelopathy is known as (acute) spinal ... The best way to visualize the spinal cord is magnetic resonance imaging (MRI). Apart from T1 and T2 MRI images, which are ... Myelopathy describes any neurologic deficit related to the spinal cord. The most common form of myelopathy in humans, cervical ...
Lumbar spinal stenosis
... but patients can have both vascular disease in the legs and spinal stenosis.[citation needed] Among people with lower-extremity ... Narrowing of spinal structures in the spinal cord such as the central canal, the lateral recesses, or the intervertebral ... This occurs as the spinal nerves or spinal cord become increasingly trapped in a smaller space within the canal. Determining ... in which case it is known as cervical spinal stenosis or thoracic spinal stenosis. Lumbar spinal stenosis can cause pain in the ...
Reticulon 4
... of this protein presents a great potential for the treatment of auto-immune mediated demyelinating diseases and spinal cord ... Moreover, vascular leakage, a major complication following stroke, was reduced following anti-Nogo-A antibody treatment. ... Schweigreiter R, Bandtlow CE (2006). "Nogo in the injured spinal cord". Journal of Neurotrauma. 23 (3-4): 384-96. doi:10.1089/ ... Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration". European Journal of ...
Timeline of Polish science and technology
... of the variable vascularity of the spinal cord was an important contribution to the development of modern clinical vascular ... He is known for Mikulicz' disease, Heineke-Mikulicz strictureplasty, Mikulicz's drain. Aleksander Możajski, Polish-Russian ... the discoverer of the variable vascularity of the spinal cord". Ann. Thorac. Surg. 80 (5): 1971-5. doi:10.1016/j.athoracsur. ... established the localization principle of long fibers in the spinal cord (1893), and with Sterling published an early paper ( ...
Hypertensive emergency
Other common causes of hypertensive crises are autonomic hyperactivity such as pheochromocytoma, collagen-vascular diseases, ... spinal cord disorders, glomerulonephritis, head trauma, neoplasias, preeclampsia and eclampsia, hyperthyroidism and ... of normal autoregulation and an abrupt rise in systemic vascular resistance are typical initial components of the disease ... As the left ventricle becomes unable to compensate for an acute rise in systemic vascular resistance, left ventricular failure ...
Sensory ataxia
... vascular and hereditary diseases. Spinazzi M, Angelini C, Patrini C (May 2010). "Subacute sensory ataxia and optic neuropathy ... of sensory large fiber peripheral neuropathies and conditions causing dysfunction of the dorsal columns of the spinal cord due ... Sghirlanzoni A, Pareyson D, Lauria G (June 2005). "Sensory neuron diseases". Lancet Neurol. 4 (6): 349-61. doi:10.1016/S1474- ...
List of ICD-9 codes 320-389: diseases of the nervous system and sense organs
... disease 335.8 Other 335.9 Unspecified 336 Other diseases of spinal cord 336.0 Syringomyelia and syringobulbia 336.1 Vascular ... Myelopathy in other diseases classified elsewhere 336.8 Other myelopathy 336.9 Unspecified diseases of spinal cord 337 ... classified elsewhere 334.8 Other 334.9 Unspecified 335 Anterior horn cell disease 335.0 Werdnig-Hoffmann disease 335.1 Spinal ... Polyneuropathy in collagen vascular disease 357.2* Polyneuropathy in diabetes (250.5†) 357.3* Polyneuropathy in malignant ...
Neurosurgery
... mitochondria disease, and any disorder that has neural deterioration in the brain or spinal cord. While pathology has been ... Some of these divisions of neurosurgery are: Vascular neurosurgery includes clipping of aneurysms and performing carotid ... Spinal cord trauma Traumatic injuries of peripheral nerves Tumors of the spine, spinal cord and peripheral nerves Intracerebral ... Some indications for spine surgery include spinal cord compression resulting from trauma, arthritis of the spinal discs, or ...
List of MeSH codes (C10)
... spinal cord injuries MeSH C10.228.854.770.500 - central cord syndrome MeSH C10.228.854.785 - spinal cord vascular diseases MeSH ... spinal cord compression MeSH C10.228.854.765 - spinal cord neoplasms MeSH C10.228.854.765.342 - epidural neoplasms MeSH C10.228 ... spinal cord ischemia MeSH C10.228.854.785.650.100 - anterior spinal artery syndrome MeSH C10.228.854.787 - spinocerebellar ... lewy body disease MeSH C10.228.140.079.862.500 - parkinson disease MeSH C10.228.140.079.862.800 - parkinson disease, secondary ...
Krembil Research Institute
Parkinson's disease, epilepsy, stroke, brain tumours, concussions, spinal cord injuries, neuro-ophthalmologic and other ocular ... spinal cord injuries, cerebral ischemia (stroke), vascular brain malformations, aneurysms, brain tumours and pain disorders. ... A. Lozano & S. Kennedy, 2003) Neural adult stem cell transplantation findings show promising results in repairing spinal cord ... nervous system as they develop treatments for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, ...
Neuromodulation (medicine)
... peripheral vascular disease and angina. The general process for spinal cord stimulation involves a temporary trailing of ... Spinal cord stimulation is a form of invasive neuromodulation therapy in common use since the 1980s. Its principal use is as a ... All forms of spinal cord stimulation have been shown to have varying degrees of efficacy to address a variety of ... DBS therapy, unlike spinal cord stimulation, has a variety of central nervous system targets, depending on the target pathology ...
Uppsala University Hospital
Urology diseases Vascular surgery "Årsredovisning och korta fakta". www.akademiska.se (in Swedish). Retrieved 2019-08-12. ... rehabilitation Prosthesis Rehabilitation of spinal cord injuries Surgical treatment and radio therapy for cancer Thoracic ... hepatology Gynecological endocrinology and infertility Immune deficiency diseases Neuro Centre, neurology, neurophysiology ... Geriatrics Gastroenterology Haematology Hepatology Hospital Physics Immunology and Transfusion Medicine Infectious Diseases ...
AVM
... may refer to: Acute viral meningitis, inflammation of the protective membranes covering the brain and spinal cord, caused ... a fatal neurological disease ActionScript Virtual Machine, a component of Adobe Flash Player Adaptive Vehicle Make, a United ... by a viral infection Arteriovenous malformation, a congenital disorder of the veins and arteries that make up the vascular ...
Cerebrolysin
... cerebral palsy and spinal cord injury though research is still preliminary. In trials studying the use of cerebrolysin after ... research indicate a possible improvement in cognitive function using cerebrolysin for vascular dementia and Alzheimer's disease ... a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered ... Cui S, Chen N, Yang M, Guo J, Zhou M, Zhu C, He L (November 2019). "Cerebrolysin for vascular dementia". The Cochrane Database ...
Netrin
"Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord". Proceedings of the ... This finding has implications in the future treatment of vascular disease in the placenta. In adults, netrin has been ... Mice with mutations in the netrin-1 gene were observed to be lacking in forebrain and spinal cord commissural axons. Netrin-1 ... Also, the migration of adult neural progenitor cell and adult spinal cord progenitor cells to the spine is netrin 1 dependent. ...
Pathophysiology of Parkinson's disease
The activated motor neurons then transmit their signals, via action potential, to motor neurons in the spinal cord. However, ... breakdown resulting in vascular leakiness. The first major proposed cause of neuronal death in Parkinson's disease is the ... Disruption of the autophagy mechanism can lead to several different types of diseases like Parkinson's disease. Autophagy ... but is believed to be disrupted in Parkinson's disease and Alzheimer's disease. This then causes cells to stop growing and ...
Fucosidosis
... heart Intellectual disability Seizures Abnormal bone formation of many bones Progressive deterioration of brain and spinal cord ... The disease itself is extremely rare (less than 100 documented cases) only affecting 1:2,000,000, with most cases occurring in ... In the more severe forms (type 1), "patients have no vascular lesions, but have rapid psychomotor regression, severe and ... Fucosidosis is now considered to be a single disorder and "represents a disease spectrum with a wide variety of expression." ...
Arteriovenous Malformations and Fistulas (AVM/AVF) of the Spinal Cord: Practice Essentials, Background, History of the Procedure
... and interwoven vascular structures that perfuse the spinal parenchyma. Spinal cord vascular malformations (arterial and venous ... represent a heterogenous group of blood vessel disorders that affect the spinal cord parenchyma either directly or indirectly. ... The spinal cord is composed of neuronal pathways, glial tissue, ... Vascular diseases of the spinal cord. Neurol Clin. 2013 Feb. 31 ... Spinal cord vascular shunts: spinal cord vascular malformations and dural arteriovenous fistulas. Neurosurg Focus. 2009 Jan. 26 ...
Peter Staats - Wikipedia
Spinal Cord Hemorrhage: Background, Pathophysiology, Epidemiology
It most commonly is caused by trauma, vascular malformations, or bleeding diatheses and can be intramedullary, subarachnoid, ... Vascular Diseases of the Spinal Cord: Infarction, Hemorrhage, and Venous Congestive Myelopathy. Semin Ultrasound CT MR. 2016 ... Vascular supply and venous drainage of the spinal cord. The cross-sectional blood supply of the spinal cord can be divided into ... 1] Spinal cord hemorrhage is most commonly caused by trauma, vascular malformations, or bleeding diatheses. Spinal cord ...
Spinal Cord Ischemia | Harvard Catalyst Profiles | Harvard Catalyst
Spinal Cord Diseases [C10.228.854]. *Spinal Cord Vascular Diseases [C10.228.854.785]. *Spinal Cord Ischemia [C10.228.854.785. ... Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries ... "Spinal Cord Ischemia" by people in Harvard Catalyst Profiles by year, and whether "Spinal Cord Ischemia" was a major or minor ... Preoperative Spinal Drain Placement is Associated with Reduced Risk of Spinal Cord Ischemia in Patients Undergoing Thoracic ...
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Vascular Disease. Respiratory Diseases. Diseases Affecting the Brain. Spinal Cord Disorders. Diseases of the Autonomic and ... Endocrine Disease. Hematologic Disorders. Skin and Musculoskeletal Diseases. Infectious Diseases. Cancer. Diseases Related to ... Ischemic Heart Disease. Valvular Heart Disease. Congenital Heart Disease. Abnormalities of Cardiac Conduction and Cardiac ... Psychiatric Disease, Substance Abuse, and Drug Overdose. Pregnancy-Associated Diseases. Pediatric Diseases. Geriatric Disorders ...
Foix-Alajouanine Syndrome Medication: Corticosteroids, Anticoagulants, Hematologic, Antibiotics, Other
... cervical cord involvement is rare. Findings include necrosis of the affected cord regions. ... malformation of the spinal cord predominantly affecting the lower thoracic and/or lumbosacral levels; ... Diseases & Conditions Epidural Hematoma * 2002248456-overviewProcedures. Procedures Vascular Malformations of the Spinal Cord ... Photomicrograph of the cervical spinal cord region showing a thickened subarachnoid vein with a thrombotic occlusion ( ...
Magnetic Resonance Imaging of the Brain and Spine, Fourth edition, Two-Volume Set, edited by Scott W. Atlas
Neoplastic Disease of the Spine and Spinal Cord *Spinal Trauma *Vascular Disorders of the Spine and Spinal Cord *Spinal ... Spine and Spinal Cord. *Congenital Anomalies of the Spine and Spinal Cord: Embryology and Malformations *Degenerative Disease ... Psychiatric Disease *MR Spectroscopy and the Biochemical Basis of Neurological Disease *Contrast Agents and Molecular MR. Index ... Normal Aging, Dementia, and Neurodegenerative Disease. Volume Two. Skull Base. *The Skull Base *The Sella Turcica and ...
Walking abnormalities: MedlinePlus Medical Encyclopedia
Problems with the joints, (such as arthritis), bones (such as deformities), circulation (such as peripheral vascular disease), ... Problems with the joints, (such as arthritis), bones (such as deformities), circulation (such as peripheral vascular disease), ... Diseases or injuries to the nerves, muscles, brain, spinal cord, or inner ear can affect normal walking. ... Problems with the joints, (such as arthritis), bones (such as deformities), circulation (such as peripheral vascular disease), ...
Finley Goold Online Presentations Channel
Spinal Cord - EMCrit Project
Acute Myelopathy: Vascular and Infectious Diseases. Neurol Clin. 2021 May;39(2):489-512. doi: 10.1016/j.ncl.2021.01.011 [PubMed ... Neck hyperextension cervical spinal cord injury (spinal cord contusion).. *Syrinx (dilation of the central canal of the spinal ... defining the level of a spinal cord lesion. *Sensory spinal cord level: *Light touch is perceived by both the spinothalamic ... The cauda equina is composed of nerve roots L2-L5 and S1-S5, which exit the spinal cord below the end of the spinal cord ( ...
Posterior Myelopathy (Posterior Spinal Artery Syndrome) - MedFriendly.com
Posterior myelopathy is considered a type of vascular myelopathy or vascular disease of the spinal cord. Vascular refers to the ... In the spinal cord, the posterior horn is a horn-shaped area of gray matter (tissue), which ... matter regions supplied by the posterior spinal artery. White matter is a group of white nerve fibers that conduct nerve ...
Neurosurgery - Wikipedia
Neuropathology is a specialty within the study of pathology focused on the disease of the brain, spinal cord, and neural tissue ... Vascular neurosurgery includes clipping of aneurysms and performing carotid endarterectomy (CEA).. *Stereotactic neurosurgery, ... Some indications for spine surgery include spinal cord compression resulting from trauma, arthritis of the spinal discs, or ... mitochondria disease, and any disorder that has neural deterioration in the brain or spinal cord.[34][35] ...
Edward Lebowitz | Stanford Medicine
This encompasses spinal cord and spine disease, degenerative and demyelinating diseases of the central nervous system, strokes ... Professor of Surgery (Vascular Surgery) Clinical Focus Vascular Surgery, Peripheral Arterial Disease, Aortic Aneurysms, Carotid ... animal models of arterial disease, arterial remodeling and flow changes in spinal cord injury, genetic regulation of arterial ... Professor of Surgery (Vascular), Emeritus Clinical Focus Vascular Surgery Research Interests I am interested in thrombosis and ...
Nervous System Problems
Briefly discusses what happens when diseases or injuries affect the nervous system. Covers emergency symptoms like loss of ... Blood supply problems (vascular disorders).. *Injuries (trauma), especially injuries to the head and spinal cord. ... If you have a condition such as diabetes, HIV, cancer, or heart disease, you may need to pay closer attention to certain ... The brain and spinal cord (central nervous system). *The nerve cells that control how you feel pain, touch, or temperature ( ...
Plus it
... abnormalities is widely available and it is known from previously published articles that selective spinal cord tract disease ... or vascular disease. Because in such cases it is uncommon to obtain pathologic correlation and because we seldom determine the ... abnormal cord signal and spinal cord atrophy) found in the more severely affected patients. It is surprising and somewhat ... be applied to normal-appearing cord tissue to show decreased MTRs in affected spinal cords? Although these and other issues are ...
Table 2 - Lineage 2 West Nile Virus as Cause of Fatal Neurologic Disease in Horses, South Africa - Volume 15, Number 6-June...
Lesions in gray matter and meninges of lumbar spinal cord (pericentral canal gliosis, edema, gray matter gliosis with ... Subtle lesions on brain and cerebellum sections (e.g., gliosis and spongiosis in white matter and vascular leukostasis). ... Marked white matter lesions in peripheral lateral and ventromedial spinal cord white matter, mild perivascular round cell ... less-marked lesions in rest of spinal cord and white matter of midbrain. ...
EMF-Portal | Literature search results
Biorphen, Vazculep (phenylephrine IV) dosing, indications, interactions, adverse effects, and more
... especially in patients with peripheral vascular disease. Patients with spinal cord injury or other autonomic dysfunction may ... Disease-associated maternal and/or embryofetal risk. *Untreated hypotension associated with spinal anesthesia for cesarean ... myocardial disease, or severe coronary artery disease; may also increase pulmonary arterial pressure and precipitate angina in ... End-stage renal disease (ESRD): Dose-response data indicate increased responsiveness to phenylephrine ...
Textbook of the Neurogenic Bladder, Second Edition, by Nyle C. Brady, Raymond Weil
Tumors of the spinal cord *Tethered cord syndrome Traumatic injuries of the central nervous system *Spinal cord injury and ... Lyme s disease). Vascular pathologies and tumors of the brain *Cerebrovascular accidents, intracranial tumors, and urologic ... Fertility issues in men with spinal cord injury * Pregnancy in spinal cord injury Prognosis and follow-up *Evolution and follow ... Disc prolapse and tumors of the spinal cord *Intervertebral disc prolapse *The cauda equina syndrome * ...
Pedretti's Occupational Therapy - Elsevier eBook on VitalSource (Access Card), 8th Edition - 9780323339339
Huntingtons Disease Section 4: Multiple Sclerosis Section 5: Parkinsons Disease 36. Spinal Cord Injury 37. Neurogenic and ... Cerebral Vascular Accident/Stroke 34. Traumatic Brain Injury 35. Degenerative Diseases of the Central Nervous System Section 1 ... UPDATED! Completely revised Spinal Cord Injury chapter addresses restoration of available musculature; self-care; independent ... Cardiac and Pulmonary Diseases 45. Oncology 46. Special Needs of the Older Adult 47. HIV Infection and AIDS 48. Polytrauma and ...
Class Notes
... complex vascular malformations and occlusive cerebrovascular disorders including Moyamoya disease. He has also spearheaded ... several early phase clinical trials of stem cell transplantation for chronic stroke and subacute spinal cord injury. Dr. ... Cerebrovascular Diseases, the Journal of Stroke and Cerebrovascular Diseases, Indian Journal of Neurosurgery and World ... congenital heart disease, and neoplasia. His work on hypertension, which affects one billion people worldwide, has demonstrated ...
Institute for Cell Engineering | Johns Hopkins Medicine
... focus on a wide range of conditions including Parkinsons disease, ALS, diabetes, heart failure, cancer, stroke and spinal cord ... Our four basic research programs, Immunobiology, Neuroregeneration, Stem Cell Biology and Vascular Biology, ... stroke and spinal cord injury among many more. ... such as Parkinsons disease and Alzheimers disease as well as ... Our four basic research programs focus on a wide range of conditions including Parkinsons disease, ALS, cancer, diabetes, ...
Leave the Brain Out of It: Spinal Stimulation Could Offer an Alternative to Treat Parkinson's Motor Symptoms | Parkinson's...
Spinal cord stimulation could expand the benefits of deep brain stimulation on Parkinsons disease motor symptoms to more ... Image of spinal cord and nervous system courtesy of NIH. Deep brain stimulation is a game changer for many Parkinsons disease ... If successful, this procedure would be an alternative for patients who may not be able to have DBS because of vascular problems ... Spinal cord stimulation is already used to treat chronic pain. Researchers are fine-tuning the application to work on the ...
National Ambulatory Medical Care Survey, 1996
Pulmonary Diseases RHU - Rheumatology SCI - Spinal Cord Injury SM - Sleep Medicine SO - Surgical Oncology TRS - Traumatic ... Vascular Disorders, Cerebral/Peripheral 0505 Agents Used to Treat Shock/Hypotension 0506 Antihypertensive Agents 0507 Diuretics ... Diseases of the Nervous System 2350-2399 Diseases of the Eye 2400-2449 Diseases of the Ear 2450-2499 Diseases of the ... Diseases of the Digestive System 2650-2699 Diseases of the Genitourinary System 2700-2799 Diseases of the Skin and Subcutaneous ...
Global Vascular Boot Market Analysis, Size & Forecast 2033
Global Vascular Boot Market revenue is currently valued at US$ 1.1 billion by 2023 and is expected to reach US$ 1.5 billion by ... spinal cord injury, peripheral vascular disease and many more. Therefore, such advantageous benefit provided by vascular boot ... The increased number of spinal cord surgeries performed due to the increased rate of spinal cord injuries supplements the ... spinal cord injury, peripheral vascular disease and many more, together with increasing healthcare expenditure is boosting the ...
RFA-NS-24-006: Community-Engaged Health Equity Research in Neuroscience Initiative (R01 CT Not Allowed)
... vascular cognitive impairment, epilepsy, migraine, nervous system infections, spinal cord injury, headache, Parkinsons disease ... These disorders include traumatic brain injury, Alzheimers disease and related dementias, Parkinsons disease, pain, epilepsy ... Research areas include but are not limited to stroke and other cerebrovascular diseases, Alzheimers disease and related ... Disparities in neurological diseases can not be explained by biological risk factors alone and social determinants of health ( ...
SSA - POMS: DI 28040.130 - Development Guidelines for Medical Improvement Not Expected (MINE) or MINE-Equivalent Impairments -...
Central nervous system vascular accident, Parkinsonian syndrome, cerebral palsy, spinal cord or nerve root lesions, Multiple ... Chronic kidney disease, with chronic hemodialysis or peritoneal dialysis and chronic kidney disease, with impairment of kidney ... Ischemic heart disease with chest pain of cardiac origin If there has been no surgical intervention and the individual reports ... degenerative disease such as Huntingtons chorea, Friedrichs ataxia, and spino-cerebellar degeneration, with manifestations as ...
Motor Neurons News, Research
Study offers clues about the biology of cells in the spinal cord that die off in ALS New research offers clues about the ... biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. ... Study provides insights into the coordinated dance of nerve and vascular cells Nerve cells need a lot of energy and oxygen. ... Spinal cord stimulation technology instantly improves arm and hand mobility in stroke patients A neurotechnology that ...
Paralysis - dogs - Lort Smith Animal Hospital
Spinal cord and nerve injury can be due to trauma, vascular disease such as a blood clot, some infectious and inflammatory ... There are many possible causes of paralysis, but is usually associated with an injury of the spinal cord or nerves supplying ... Remember that animals with paralysis may have a spinal cord injury and should be handled very gently. ... diseases, degenerative diseases and some cancers. Severe weakness may mimic paralysis. This is most likely to occur in older ...
Paget's Disease Of Bone
Overview of Pagets disease, and how to treat it in a natural way. ... the patients may experience collapse of the vertebra or vascular changes that may have an effect on the spinal cord resulting ... Pagets Disease Of Bone. Pagets disease, whose name has been derived from the famous British surgeon Sir James Paget, is a ... In addition, a very unusual type of Pagets disease is found in children, which is known as juvenile Pagets disease. ...