Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
Pathologic conditions which feature SPINAL CORD damage or dysfunction, including disorders involving the meninges and perimeningeal spaces surrounding the spinal cord. Traumatic injuries, vascular diseases, infections, and inflammatory/autoimmune processes may affect the spinal cord.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Renewal or physiological repair of damaged nerve tissue.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60)
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
Dysfunction of the URINARY BLADDER due to disease of the central or peripheral nervous system pathways involved in the control of URINATION. This is often associated with SPINAL CORD DISEASES, but may also be caused by BRAIN DISEASES or PERIPHERAL NERVE DISEASES.
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
Chairs mounted on wheels and designed to be propelled by the occupant.
Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.
Injuries resulting in hemorrhage, usually manifested in the skin.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Injuries involving the vertebral column.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.
Neurons which activate MUSCLE CELLS.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.
A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.
A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.
Paired bundles of NERVE FIBERS entering and leaving the SPINAL CORD at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots are efferent, comprising the axons of spinal motor and PREGANGLIONIC AUTONOMIC FIBERS.
Injuries incurred during participation in competitive or non-competitive sports.
The physical activity of a human or an animal as a behavioral phenomenon.
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
Elements of limited time intervals, contributing to particular results or situations.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts.
Any operation on the spinal cord. (Stedman, 26th ed)
An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures.
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Passage of a CATHETER into the URINARY BLADDER or kidney.
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES.
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Procedure in which an anesthetic is injected directly into the spinal cord.
The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Use of electric potential or currents to elicit biological responses.
Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
X-ray visualization of the spinal cord following injection of contrast medium into the spinal arachnoid space.
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
Facilities which provide programs for rehabilitating the mentally or physically disabled individuals.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Narrowing of the spinal canal.
The development of bony substance in normally soft structures.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.
Act of eliciting a response from a person or organism through physical contact.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The mechanical laws of fluid dynamics as they apply to urine transport.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
A front limb of a quadruped. (The Random House College Dictionary, 1980)
A rare epidural hematoma in the spinal epidural space, usually due to a vascular malformation (CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS) or TRAUMA. Spontaneous spinal epidural hematoma is a neurologic emergency due to a rapidly evolving compressive MYELOPATHY.
Space between the dura mater and the walls of the vertebral canal.
A monosynaptic reflex elicited by stimulating a nerve, particularly the tibial nerve, with an electric shock.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
General or unspecified injuries involving the leg.
Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.
Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
Discharge of URINE, liquid waste processed by the KIDNEY, from the body.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
The spinal or vertebral column.
Injuries to the PERIPHERAL NERVES.
The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.
The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.
The observable response an animal makes to any situation.
The emission of SEMEN to the exterior, resulting from the contraction of muscles surrounding the male internal urogenital ducts.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
Longitudinal cavities in the spinal cord, most often in the cervical region, which may extend for multiple spinal levels. The cavities are lined by dense, gliogenous tissue and may be associated with SPINAL CORD NEOPLASMS; spinal cord traumatic injuries; and vascular malformations. Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile sense preserved (sensory dissociation). Lower extremity spasticity and incontinence may also develop. (From Adams et al., Principles of Neurology, 6th ed, p1269)
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
Penetrating wounds caused by a pointed object.
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.
Apparatus used to support, align, prevent, or correct deformities or to improve the function of movable parts of the body.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Manner or style of walking.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Any method of measuring the amount of work done by an organism, usually during PHYSICAL EXERTION. Ergometry also includes measures of power. Some instruments used in these determinations include the hand crank and the bicycle ergometer.
Amount of stimulation required before the sensation of pain is experienced.
The position or attitude of the body.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
A PREDNISOLONE derivative with similar anti-inflammatory action.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
The application of electronic, computerized control systems to mechanical devices designed to perform human functions. Formerly restricted to industry, but nowadays applied to artificial organs controlled by bionic (bioelectronic) devices, like automated insulin pumps and other prostheses.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
General or unspecified injuries to the chest area.
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
Pathological processes of the URINARY BLADDER.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Broken bones in the vertebral column.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.
Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
Former members of the armed services.
The inferior part of the lower extremity between the KNEE and the ANKLE.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.
One of three bones that make up the coxal bone of the pelvic girdle. In tetrapods, it is the part of the pelvis that projects backward on the ventral side, and in primates, it bears the weight of the sitting animal.
Persistent pain that is refractory to some or all forms of treatment.
Neural tracts connecting one part of the nervous system with another.
A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
Refers to animals in the period of time just after birth.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Medical devices which substitute for a nervous system function by electrically stimulating the nerves directly and monitoring the response to the electrical stimulation.
General or unspecified injuries involving organs in the abdominal cavity.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.
The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.
General or unspecified injuries involving the arm.
A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.
A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Stones in the URINARY BLADDER; also known as vesical calculi, bladder stones, or cystoliths.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.

Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade. (1/4276)

This study characterized gene transfer into both normal and injured adult rat dorsal spinal cord using first (E1-/E3-) or second (E1-/E2A125/E3-, temperature-sensitive; ts) generation of replication-defective adenoviral (Ad) vectors. A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence. In addition, the effect of gene transfer on nociception was also evaluated. Seven days after treatment, numerous LacZ-positive cells were observed after transfection with either viral vector. By 21 days after transfection, beta-galactosidase staining was reduced and suggestive of ongoing cytopathology in both Ad-treated groups, despite the fact that the immunogenicity of LacZ/Adts appeared less when compared with that elicited by the LacZ/Ad vector. In contrast, immunosuppressed animals showed a significant (P < or = 0.05) increase in the number of LacZ-positive cells not displaying cytopathology. In these animals, a concomitant reduction in numbers of macrophages/microglia and CD4 and CD8 lymphocytes was observed. Only animals that received LacZ/Adts and immunosuppression showed transgene expression after 60 days. Similar results were observed in animals in which the L4-L5 dorsal roots were lesioned before transfection. Gene transfer into the dorsal spinal cord did not affect nociception, independent of the adenovirus vector. These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.  (+info)

Complete compensation in skilled reaching success with associated impairments in limb synergies, after dorsal column lesion in the rat. (2/4276)

Each of the dorsal columns of the rat spinal cord conveys primary sensory information, by way of the medullary dorsal column nucleus, to the ventrobasal thalamus on the contralateral side; thus the dorsal columns are an important source of neural input to the sensorimotor cortex. Damage to the dorsal columns causes impairments in synergistic proximal or whole-body movements in cats and distal limb impairments in primates, particularly in multiarticulated finger movements and tactile foviation while handling objects, but the behavioral effects of afferent fiber lesions in the dorsal columns of rodents have not been described. Female Long-Evans rats were trained to reach with a forelimb for food pellets and subsequently received lesions of the dorsomedial spinal cord at the C2 level, ipsilateral to their preferred limb. Reaching success completely recovered within a few days of dorsal column lesion. Nevertheless, a detailed analysis of high-speed video recordings revealed that rotatory limb movements (aiming, pronation, supination, etc.) were irreversibly impaired. Compensation was achieved with whole-body and alternate limb movements. These results indicate the following: (1) in the absence of the dorsal columns, other sensorimotor pathways support endpoint success in reaching; (2) sensory input conveyed by the dorsal columns is important for both proximal and distal limb movements used for skilled reaching; and (3) detailed behavioral analyses in addition to endpoint measures are necessary to completely describe the effects of dorsal column lesions.  (+info)

Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (3/4276)

The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes.  (+info)

Disabling injuries of the cervical spine in Argentine rugby over the last 20 years. (4/4276)

OBJECTIVE: To investigate the incidence and risk factors of disabling injuries to the cervical spine in rugby in Argentina. METHODS: A retrospective review of all cases reported to the Medical Committee of the Argentine Rugby Union (UAR) and Rugby Amistad Foundation was carried out including a follow up by phone. Cumulative binomial distribution, chi 2 test, Fisher test, and comparison of proportions were used to analyse relative incidence and risk of injury by position and by phase of play (Epi Info 6, Version 6.04a). RESULTS: Eighteen cases of disabling injury to the cervical spine were recorded from 1977 to 1997 (0.9 cases per year). The forwards (14 cases) were more prone to disabling injury of the cervical spine than the backs (four cases) (p = 0.03). Hookers (9/18) were at highest risk of injury (p < 0.01). The most frequent cervical injuries occurred at the 4th, 5th, and 6th vertebrae. Seventeen of the injuries occurred during match play. Set scrums were responsible for most of the injuries (11/18) but this was not statistically significant (p = 0.44). The mean age of the injured players was 22. Tetraplegia was initially found in all cases. Physical rehabilitation has been limited to the proximal muscles of the upper limbs, except for two cases of complete recovery. One death, on the seventh day after injury, was reported. CONCLUSIONS: The forwards suffered a higher number of injuries than the backs and this difference was statistically significant. The chance of injury for hookers was statistically higher than for the rest of the players and it was particularly linked to scrummaging. However, the number of injuries incurred in scrums was not statistically different from the number incurred in other phases of play.  (+info)

Energy cost of propulsion in standard and ultralight wheelchairs in people with spinal cord injuries. (5/4276)

BACKGROUND AND PURPOSE: Wheelchair- and subject-related factors influence the efficiency of wheelchair propulsion. The purpose of this study was to compare wheelchair propulsion in ultralight and standard wheelchairs in people with different levels of spinal cord injury. SUBJECTS: Seventy-four subjects (mean age=26.2 years, SD=7.14, range=17-50) with spinal cord injury resulting in motor loss (30 with tetraplegia and 44 with paraplegia) were studied. METHOD: Each subject propelled standard and ultralight wheelchairs around an outdoor track at self-selected speeds, while data were collected at 4 predetermined intervals. Speed, distance traveled, and oxygen cost (VO2 mL/kg/m) were compared by wheelchair, group, and over time, using a Bonferroni correction. RESULTS: In the ultralight wheelchair, speed and distance traveled were greater for both subjects with paraplegia and subjects with tetraplegia, whereas VO2 was less only for subjects with paraplegia. Subjects with paraplegia propelled faster and farther than did subjects with tetraplegia. CONCLUSION AND DISCUSSION: The ultralight wheelchair improved the efficiency of propulsion in the tested subjects. Subjects with tetraplegia, especially at the C6 level, are limited in their ability to propel a wheelchair.  (+info)

Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans. (6/4276)

Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of approximately 1 l/min, heart rate increased from 66 +/- 4 to 86 +/- 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 +/- 3 to 110 +/- 8 beats/min. In contrast, blood pressure increased only in C (from 88 +/- 3 to 99 +/- 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI.  (+info)

M2 receptors in genito-urinary smooth muscle pathology. (7/4276)

In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats which had their major pelvic ganglion bilaterally removed (denervation, DEN) or from rats in which the spinal cord was injured (SCI) via compression. DEN induced both hypertrophy (505+/-51 mg bladder weight) and a supersensitivity of the bladders to carbachol (EC50=0.7+/-0.1 uM). Some of the SCI rats regained the ability to void spontaneously (SPV). The bladders of these animals weighed 184+/-17 mg, significantly less than the bladders of non voiding rats (NV, 644+/-92 mg). The potency of carbachol was greater in bladder strips from NV SCI animals (EC50=0.54+/-0.1 uM) than either bladder strips from SPV SCI (EC50=0.93+/-0.3 microM), DEN or control (EC50=1.2+/-0.1 microM) animals. Antagonist affinities in control bladders for antagonism of carbachol induced contractions were consistent with M3 mediated contractions. Antagonist affinities in DEN bladders for 4-diphenlacetoxy-N-methylpiperidine methiodide (4-DAMP, 8.5) and para fluoro hexahydrosilodifenidol (p-F-HHSiD, 6.6); were consistent with M2 mediated contractions, although the methoctramine affinity (6.5) was consistent with M3 mediated contractions. p-F-HHSiD inhibited carbachol induced contraction with an affinity consistent with M2 receptors in bladders from NV SCI (pKb=6.4) animals and M3 receptors in bladders from SPV SCI animals (pKb=7.9). Subtype selective immunoprecipitation of muscarinic receptors revealed an increase in total and an increase in M2 receptor density with no change in M3 receptor density in bladders from DEN and NV SCI animals compared to normal or sham operated controls. M3 receptor density was lower in bladders from SPV SCI animals while the M2 receptor density was not different from control. This increase in M2 receptor density is consistent with the change in affinity of the antagonists for inhibition of carbachol induced contractions and may indicate that M2 receptors or a combination of M2 and M3 receptors directly mediate smooth muscle contraction in bladders from DEN and NV SCI rats.  (+info)

Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury. (8/4276)

Upon noxious stimulation, substance P (SP) is released from primary afferent fibers into the spinal cord where it interacts with the SP receptor (SPR). The SPR is located throughout the dorsal horn and undergoes endocytosis after agonist binding, which provides a spatial image of SPR-containing neurons that undergo agonist interaction. Under normal conditions, SPR internalization occurs only in SPR+ cell bodies and dendrites in the superficial dorsal horn after noxious stimulation. After nerve transection and inflammation, SPR immunoreactivity increases, and both noxious as well as nonnoxious stimulation produces SPR internalization in the superficial and deep dorsal horn. We investigated the primary afferent fibers that contribute to enhanced SPR internalization in the spinal cord after nerve transection and inflammation. Internalization evoked by electrical stimulation of the sciatic nerve was examined in untreated animals, at 14 days after sciatic nerve transection or sham surgery and at 3 days after hindpaw inflammation. Electrical stimulation was delivered at intensities to excite Abeta fibers only, Abeta and Adelta fibers or A and C fibers as determined by the compound action potential recorded from the tibial nerve. Electrical stimuli were delivered at a constant rate of 10 Hz for a duration of 5 min. Transection of the sciatic nerve and inflammation produced a 33.7 and 32.5% increase in SPR and immunoreactivity in lamina I, respectively. Under normal conditions, stimulation of Adelta or C fibers evoked internalization that was confined to the superficial dorsal horn. After transection or inflammation, there was a 20-24% increase in the proportion of SPR+ lamina I neurons that exhibited internalization evoked by stimulation of Adelta fibers. The proportion of lamina I SPR+ neurons that exhibited internalization after stimulation of C-fibers was not altered by transection or inflammation because this was nearly maximal under normal conditions. Moreover, electrical stimulation sufficient to excite C fibers evoked SPR internalization in 22% of SPR+ lamina III neurons after nerve transection and in 32-36% of SPR+ neurons in lamina III and IV after inflammation. Stimulation of Abeta fibers alone never evoked internalization in the superficial or deep dorsal horn. These results indicate that activation of small-caliber afferent fibers contributes to the enhanced SPR internalization in the spinal cord after nerve transection and inflammation and suggest that recruitment of neurons that possess the SPR contributes to hyperalgesia.  (+info)

Definition of acute spinal cord injury in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is acute spinal cord injury? Meaning of acute spinal cord injury as a legal term. What does acute spinal cord injury mean in law?
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing acute inflammatory cellular processes, ultimately provide protection for central nervous tissue from continuing injury following ischaemic or traumatic insult. Its clinical application within acute traumatic spinal cord injury would therefore seem very plausible, it having the potential to combat the pathophysiological secondary injury processes that can develop in the proceeding hours to days following the initial injury. As such it could offer invaluable assistance to lessen subsequent sensory, motor and autonomic dysfunction for an individual affected by this devastating condition. Yet research surrounding this interventions applicability in this field is somewhat lacking, the majority ...
GlobalDatas clinical trial report, Traumatic Spinal Cord Injury Global Clinical Trials Review, H2, 2014 provides data on the Traumatic Spinal Cord Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Traumatic Spinal Cord Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Traumatic Spinal Cord Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts ...
The extent of injury is defined by the American Spinal Injury Association (ASIA) Impairment Scale (modified from the Frankel classification), using the following categories:{ref1}{ref2} A = Complete:... more
TY - JOUR. T1 - Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system. AU - Lee, Minhyung. AU - Eun, Su Lee. AU - Young, Soo Kim. AU - Byung, Hyune Choi. AU - So, Ra Park. AU - Hyun, Seon Park. AU - Hyung, Chun Park. AU - Sung, Wan Kim. AU - Ha, Yoon. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2005/12. Y1 - 2005/12. N2 - Study Design. A spinal cord injury and in vitro neural hypoxia models were used to evaluate the hypoxia responsive gene expression. Objectives. To limit the risk of unwanted overexpression of therapeutic genes, we developed a hypoxia-inducible gene therapy system using the erythropoietin (Epo) enhancer and the RTP801 promoter. Summary of Background Data. Gene therapy is an emerging therapeutic technique to treat spinal cord injury. However, uncontrolled overexpression of therapeutic genes in nondisease tissues during gene therapy raises a doubt about its safety. Post-traumatic ischemia is an ...
Spinal Cord Injury Services are described in the National Spinal Cord Injury Pathways, launched in September 2012 which are on During 2014/15 the Provider shall agree with Commissioners a plan to progress towards full compliance with the National Spinal Cord Injury Pathways in respect of all Specialised SCI If used more widely, it is not expected that RT300 would lead to any major changes in infrastructure, but extra physiotherapy services (such as staff) may be needed. As if this wasnâ t enough, she represented Eksobionics at the Run In The Dark 5k event held by the Mark Pollock Trust at Battersea Park in November. What happens after a spinal cord injury? We are experts in securing the maximum amount of spinal cord injury compensation and getting rehabilitation support as quickly as possible. At Hobbs Rehabilitation, we offer a variety of services for treatment, management and rehabilitation of spinal cord injuries at any stage. The team are supported by a consultant who is ...
Spinal cord injuries can be life altering and devastating. Spinal cord injuries can occur as the result of a motor vehicle accident or other compensable accident, and may not always be apparent immediately following injury.. Traumatic spinal cord damage (damage caused by injury), can occur instantly or it can develop over time. A spinal cord injury typically results in full or partial loss of sensation and bodily function below the site of the injury. Some spinal cord injuries are obvious, as in paraplegia (loss of function involving the upper limbs) and quadriplegia (loss of function involving all four limbs), and some might be less obvious, at least initially, and may progress over time. A traumatic spinal cord injury might even be diagnosed as whiplash or other soft tissue injury early on. Damage to the spinal cord can be caused by compression, bruising, tearing or severing of the spinal cord, all of which can result from the forces involved in a motor vehicle accident, including whiplash ...
Director, Spinal Cord Injury Rehabilitation Program. People often ask me when or if there will ever be a cure for spinal cord injury. Although there are many differing opinions about this, I am confident there will be a cure in my lifetime. In the meantime, anyone with a spinal cord injury should have a long-term plan for their treatment and care.. The number of spinal cord injuries per year has remained fairly stable over the last two decades, with nearly 12,000 occurring each year mostly from sports injuries, car accidents and other forms of traumatic injury. Currently in the United States there are approximately 200,000 people are living with spinal cord injuries or spinal dysfunction. With todays advanced medical treatments, more spinal cord injury patients survive the trauma compared to just a few decades ago. This positive shift in mortality rate underlines the great importance of initial acute treatment and follow up rehabilitation.. Treatment for spinal cord injuries can be divided into ...
Obtenha sua edição digital de Pushin On: UAB Spinal Cord Injury Model System Digital Newsletter Volume 34 | Number 1 assinaturas e publicações online na Joomag. Compre, baixe e leia Pushin On: UAB Spinal Cord Injury Model System Digital Newsletter Volume 34 | Number 1 em seu iPad, iPhone, Android, Tablets, Kindle Fire, Windows 8, Internet, Mac e PCs apenas na Joomag - A Banca Digital.
TY - JOUR. T1 - MRI characterization of diffusion coefficients in a rat spinal cord injury model. AU - Ford, John C.. AU - Hackney, David B.. AU - Alsop, David C.. AU - Jara, Hernan. AU - Joseph, Peter M.. AU - Hand, Christopher M.. AU - Black, Perry. PY - 1994/5. Y1 - 1994/5. N2 - Apparent diffusion coefficients (ADC) were measured in a rat spinal cord weight‐drop injury model. After sacrifice, the spinal cords were fixed in situ and excised for MR imaging and ADC measurement. Diffusion is anisotropic in normal gray and white matter. There were significant decreases in ADCs measured along the longitudinal axis of the injured cord and increases in ADCs measured transverse to the cord. Injured segments demonstrated reductions in diffusion anisotropy in the white matter. Diffusion was completely isotropic at the epicenter of the weight‐drop injury. Significant decreases in longitudinal ADC and increases in transverse ADC were observed in portions of the cord which appeared normal on ...
Any type of spinal cord injury is one that can alter your life in many ways. For this reason, its important to do two things:. - Pay close attention to the health of your spinal cord.. - Receive immediate medical treatment if your spinal cord is injured in any way.. With an incomplete spinal cord injury, its difficult to know what the future will bring. However, there are several things you should know about this:. - Spinal cord injuries that do not cause complete paralysis are those with which there is a greater chance of additional recovery in the future.. - When a person still has sensation in the lower part of his or her body, there is a chance that he or she could experience some muscle recovery.. - The sooner muscles begin to work after an incomplete spinal cord injury, the better chance there is that the person will experience additional recovery, especially as it pertains to walking.. While these are some of the most important facts associated with an incomplete spinal cord injury, ...
Severe spinal cord injury is a very debilitating injury. This report presents information from the Australian Spinal Cord Injury Register on 381 cases from trauma and disease in 2004-05. During the year, 280 new cases of spinal cord injury from traumatic causes were registered in Australia, an age-adjusted incidence rate of 15.4 cases per million population. The most common clinical outcome of spinal cord injury was incomplete tetraplegia. Falling was the most common type of event leading to traumatic spinal cord injury at older ages. The Australian Spinal Cord Injury Register is a collaborative activity of the AIHW National Injury Surveillance Unit and all of the specialist spinal units in Australia.. ...
Bodily Function Control : Students with a spinal cord injury may have bodily control difficulties due to nerve damage in the spinal cord. Breathing Difficulty : Students with spinal cord injuries may have breathing difficulties due to an inability to breathe deeply. Climate Sensitivity : Students with spinal cord injury have difficulty with regulating body temperature in hot and cold weather which can cause muscle spasms, heat stroke and frost bite. Fatigue (Physical) : Students with spinal cord injuries may experience physical fatigue due to breathing issues, mobility issues, low blood pressure, or chronic pain. Motor Skill (Fine) : Spinal cord injuries can lead to decreased fine motor skill ranging from some lack of strength and control to full paralysis of fingers. Motor Skill (Gross Lower) : Students with a spinal cord injury may experience muscle spasms, especially in the heat. Motor Skill (Gross Upper) : Students with a spinal cord injury may have difficulty with muscle control or ...
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies. We propose to investigate the drug Minocycline (a metalloproteinase inhibitor) for the treatment of spinal cord injured patients aiming to limit neurological injury and improve neurological outcome. This drug influences several secondary injury mechanisms implicated in spinal cord injury and has been effective in improving outcome after spinal cord injury in animal models. We also propose to examine the safety and feasibility of spinal cord perfusion pressure augmentation with a protocol of IV fluids and inotrope medications versus standard maintenance of mean arterial pressure in subjects who exhibit a decrease in perfusion pressure to less than 75 mmHg. The purpose of this pilot study is 1) to evaluate the feasibility of a clinical trial protocol for Minocycline in patients with acute spinal cord injury, and 2) to ensure adequate drug dosing and ...
OBJECTIVE: To map the impact of spinal cord lesion (SCL) on medication. STUDY DESIGN: Registration of medication for 72 patients before SCL and at discharge from the Department for Spinal Cord Injuries. SETTING: Department for Spinal Cord Injuries, East Denmark. METHODS: The changes in medication for each Anatomical Therapeutic Chemical (ATC) Classification System group were registered for all patients, who were discharged from Department for Spinal Cord Injuries during 2010. The changes in medication per se were calculated for different parts of the population: non-traumatic, traumatic patients, men, women, paraplegia, tetraplegia, American Spinal Injury Association Impairment Scale (AIS) A, B or C, AIS D, age 0-45, 46-60 and 60+. In addition, comparisons of changes in medication were made between complementary parts of the population. RESULTS: The overall increase in medication after SCL was 3.29 times (P,0.001). Statistically significant increases were seen for most medicine categories. When ...
Health conditions in people with spinal cord injury are major determinants for disability, reduced well-being, and mortality. However, population-based evidence on the prevalence and treatment of health conditions in people with spinal cord injury is scarce.; To investigate health conditions in Swiss residents with spinal cord injury, specifically to analyse their prevalence, severity, co-occurrence, and treatment.; Cross-sectional data (n = 1,549) from the community survey of the Swiss Spinal Cord Injury (SwiSCI) cohort study, including Swiss residents with spinal cord injury aged over 16 years, were analysed. Nineteen health conditions and their self-reported treatment were assessed with the spinal cord injury Secondary Conditions Scale and the Self-Administered Comorbidity Questionnaire. Prevalence and severity were compared across demographics and spinal cord injury characteristics. Co-occurrence of health conditions was examined using a binary non-metric dissimilarity measure and ...
While the recommendations for spinesurgery in specific cases of acute traumatic spinal cord injury (SCI) are well recognized, there is considerable uncertainty regarding the role of the timing of surgical decompression of the spinal cord in the management of patients with SCI. Given this, we sought to critically review the literature regarding the pre-clinical and clinical evidence on the potential impact of timing of surgicaldecompression of the spinal cord on outcomes after traumatic SCI. The primary literature search was performed using MEDLINE, CINAHL, EMBASE, and Cochrane databases. A secondary search strategy incorporated articles referenced in prior meta-analyses and systematic and nonsystematic review articles. Two reviewers independently assessed every study with regard to eligibility, level of evidence, and studyquality. Of 198 abstracts of pre-clinical studies, 19 experimental studies using animal SCI models fulfilled our inclusion and exclusion criteria. Despite some discrepancies ...
spinal cord injuries - MedHelps spinal cord injuries Center for Information, Symptoms, Resources, Treatments and Tools for spinal cord injuries. Find spinal cord injuries information, treatments for spinal cord injuries and spinal cord injuries symptoms.
Study design: Retrospective analysis of medical records on spinal cord injury (SCI) patients with neuropathic bladder.Objective: To determine SCI patients compliance with the method of bladder management they used on discharge from inpatient rehabilitation.Setting: Ankara University Medical School, Department of Physical Medicine and Rehabilitation, Spinal Cord Injury Unit, which treats patients referred from throughout Turkey.Methods: The bladder management method of 50 new SCI patients was noted at admission, discharge and follow-up. Reasons for changing the initial method were documented. For analysis, patients were grouped by gender, level and completeness of injury. Compliance with bladder management method was compared between these groups by chi-square test.Results: The method of bladder management at admission was indwelling catheter (IC) for 86% of the patients. Most were switched to clean intermittent catheterisation (CIC) by rehabilitation discharge. Of 38 patients (76%) on CIC at discharge,
A spinal cord injury can entail anything from persistent nerve damage leading to tingling in the legs to permanent and full paralysis. Serious spinal cord injuries can require extensive physical and occupational therapy. Multiple complicated surgeries may also be needed. This can all lead to extensive medical bills and lost wages. The long and difficult road to recovery can impact every aspect of your life, from family to career and beyond. For some, a permanent and severe spinal cord injury can mean an end to any career or chance of employment in a field they may have spent years preparing for. If a spinal cord injury victim is paralyzed, expensive modifications to the home and vehicles may also be needed.. Resources: Spinal Cord Injury Statistics. ...
Few injuries result in more profound and long-term disability than traumatic spinal cord injury. This study describes the demographic and epidemiologic characteristics of traumatic spinal cord injury among Oklahoma residents reported to the statewide, population-based surveillance system in 1988-1990; initial acute hospital and rehabilitation...
For Friends and Family of the Newly Injured | Back to SCI Information How is acute spinal cord injury treated? Acute spinal cord injury refers to hours or days after spinal cord injury during which continued deterioration or tissue damage may occur. Shortly after an injury, the spinal cord often does not appear to be…
References. 1. White CC 4th, Domeier RM, Millin MG; Standards and Clinical Practice Committee, National Association of EMS Physicians. EMS spinal precautions and the use of the long backboard-Resource document to the position statement of the National Association of EMS Physicians and the American College of Surgeons Committee on Trauma. Prehosp Emerg Care, 2014 Apr-Jun; 18(2): 306-14.. 2. Devivo MJ. Epidemiology of traumatic spinal cord injury: Trends and future implications. Spinal Cord, 2012 May; 50(5): 365-72.. 3. Ropper AE, Neal MT, Theodore N. Acute management of traumatic cervical spinal cord injury. Pract Neurol, 2015 Aug; 15(4): 266-72.. 4. Hansebout RR, Kachur E. Acute traumatic spinal cord injury. UpToDate, 5. Theodore N, Hadley MN, Aarabi B, et al. Prehospital cervical spine immobilization after trauma. Neurosurgery, 2013 Mar; 72 Suppl 2: 22-34.. 6. Haut ER, Kalish BT, Efron DT, et al. Spine immobilization in penetrating ...
TY - JOUR. T1 - Effect of spinal cord injury on quality of life of affected soldiers in India. T2 - A cross-sectional study. AU - Kumar, Narinder. AU - Gupta, Bhawna. PY - 2016/4/1. Y1 - 2016/4/1. N2 - Study Design: A prospective cross-sectional study with convenience sampling approach was done to assess quality of life (QoL) in 100 soldiers and veterans affected by spinal cord injury (SCI). Purpose: SCI affects almost every aspect of the life of an affected individual. This study was done to measure the impact of SCI on QoL of affected soldiers and veterans using the WHOQOL-BREF questionnaire. Overview of Literature: The devastating effect of SCI on QoL is well known. However, this study is unique in that it includes soldiers and veterans, who constitute a large, but excluded, cohort in most demographic studies. Methods: A cross-sectional study was done at two SCI rehabilitation centres of the Indian armed forces. Data was collected by faceto- face interviews from 100 patients, which included ...
Jennifer Coker, MPH, has been a Research Associate at Craig Hospital since April 2012 and works primarily with the SCI Model Systems projects. She is Principal Investigator for the current SCI Model Systems module project, Utilization of Complementary and Integrative Healthcare to Treat Pain in Persons with Spinal Cord Injury and a Craig H Neilsen Foundation-funded project, A Bridge from Rehabilitation to Real-World: Reinventing Yourself after SCI.. Ms. Coker has worked in the field of traumatic spinal cord injury (SCI) since 1997. She obtained a Master of Public Health (MPH) from the Rollins School of Public Health at Emory University in May 2001 where she won the James W. Alley Award for Outstanding Service to Disadvantaged Populations. Ms. Coker is currently a PhD student in the Clinical Sciences program at the University of Colorado-Anschutz Medical Campus. She has presented research at national conferences of the American Spinal Injury Association, the American Association of Spinal ...
Management of the neurogenic bladder has the primary objectives of maintaining continence, ensuring low bladder pressure (to avoid renal damage) and avoiding or minimising infection. Options include intermittent urethral catheterisation, indwelling urethral or suprapubic catheterisation, timed voiding, use of external catheter (for men), drug treatment, augmentation cystoplasty and urinary diversion. [1] Long-term indwelling urethral catheterisation is common amongst people with cervical spinal cord injury; however, this carries a high risk of developing a catheter-related urinary tract infection and associated complications especially bypassing and leakage. [2, 3]. Carers and health professionals tend to assume that urethral catheter drainage is satisfactory in spinal cord injury patients if the catheter is draining clear urine, there is no blood in urethral meatus, and the patient does not develop features of autonomic dysreflexia. In male spinal cord injury patients, the balloon of a Foley ...
The Covid-19 pandemic has been an unprecedented time for all, with or without disability. Persons with spinal cord injury are more vulnerable than others, and were left to fear severe complications and poor disease outcome. When confronted with protective measures and a lockdown, the physical, psychological and social needs of those persons in a wheelchair cannot be overstated. Thats why this year focus Spinal Cord Injury Day 2020 will be on the prevention of Covid-19 for persons with spinal cord injury, with the slogan Covid-19 and SCI: Staying well.. According to World Health Organization (WHO) between 2,50,000 and 5,00,000 people suffer a spinal cord injury (SCI) around the world, every year. Most of the spinal cord injuries are due to the avoidable reasons such as road accidents, falls or violence. As per the statistics from USA, depending on the severity, SCI can cost an injured individual USD 334,000 to 1 million in the first year after injury. Costs in each subsequent year range from ...
Spinal cord injuries are either complete or incomplete. A complete spinal cord injury causes a total loss of function below the injury. For this reason, a complete SCI in the neck results in a loss of function of all limbs and the torso (quadriplegia/tetraplegia), while the same injury in the middle or lower back results in a loss of function of part of the torso and the legs (paraplegia). An incomplete SCI may result in pain to partial paralysis and anything in between. Unfortunately, medical advances in this area have been modest. Thanks to new rehabilitation techniques, a complete SCI may convert to an incomplete SCI, but whether the injury is complete or incomplete, the effect on quality of life is always significant.. The lawyers at Litwiniuk & Company have comprehensive experience negotiating on behalf of clients who have suffered spinal cord injuries. We know there will be extensive costs for medical treatment and rehabilitation, wheelchairs or other mobility aids, and even home ...
Movement is planned and coordinated by the brain and carried out by contracting muscles acting on specific joints. Motor commands initiated in the brain travel through descending pathways in the spinal cord to effector motor neurons before reaching target muscles. Damage to these pathways by spinal cord injury (SCI) can result in paralysis below the injury level. However, the planning and coordination centers of the brain, as well as peripheral nerves and the muscles that they act upon, remain functional. Neuroprosthetic devices can restore motor function following SCI by direct electrical stimulation of the neuromuscular system. Unfortunately, conventional neuroprosthetic techniques are limited by a myriad of factors that include, but are not limited to, a lack of characterization of non-linear input/output system dynamics, mechanical coupling, limited number of degrees of freedom, high power consumption, large device size, and rapid onset of muscle fatigue. Wireless multi-channel closed-loop
TY - JOUR. T1 - Does being female provide a neuroprotective advantage following spinal cord injury?. AU - Datto, Jeffrey P.. AU - Yang, Jackie. AU - Dietrich, W. Dalton. AU - Pearse, Damien D.. N1 - Publisher Copyright: © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.. PY - 2015/10/30. Y1 - 2015/10/30. N2 - It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration ...
TY - JOUR. T1 - Meta-Analysis of Pre-Clinical Studies of Early Decompression in Acute Spinal Cord Injury. T2 - A Battle of Time and Pressure. AU - Batchelor, Peter E.. AU - Wills, Taryn E.. AU - Skeers, Peta. AU - Battistuzzo, Camila R.. AU - Macleod, Malcolm R.. AU - Howells, David W.. AU - Sena, Emily S.. PY - 2013/8/23. Y1 - 2013/8/23. N2 - Background:The use of early decompression in the management of acute spinal cord injury (SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a small number of supportive clinical studies. Although the pre-clinical literature favours the concept of early decompression, translation is hindered by uncertainties regarding overall treatment efficacy and timing of decompression.Methods:We performed meta-analysis to examine the pre-clinical literature on acute decompression of the injured spinal cord. Three databases were utilised; PubMed, ISI Web of Science and Embase. Our inclusion criteria consisted of (i) the reporting of ...
This submission demonstrates the unique contribution made by my research to our understanding of physiological responses and their regulation during exercise and heat stress in individuals with traumatic spinal cord injury, and thus that I have met the conditions required for the award of PhD by Publication.This submission demonstrates the unique contribution made by my research to our understanding of physiological responses and their regulation during exercise and heat stress in individuals with traumatic spinal cord injury, and thus that I have met the conditions required for the award of PhD by Publication ...
Spinal Cord Injury Ring,This ring contains web pages that pertain exclusively to spinal cord injury, spinal cord injury resources, and spinal cord injury rehabilitation facilities.
Extensive oligodendrocyte death after acute traumatic spinal cord injuries (TSCI) leads to axon demyelination and subsequently may leave axons vulnerable to degeneration. Despite the present evidence showing spontaneous remyelination after TSCI the cellular origin of new myelin and the time course of the axon ensheatment/remyelination remained controversial issue. In this systematic review the trend of oligodendrocyte death after injury as well as the extent and the cellular origin of oligodendrogliogenesis were comprehensively evaluated. The study design was based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-guided systematic review. PubMed and EMBASE were searched with no temporal or linguistic restrictions. Also, hand-search was performed in the bibliographies of relevant articles. Non-interventional animal studies discussing different types of myelinating cells including oligodendrocytes, Schwann cells and oligodendrocyte progenitor cells (OPCs) were ...
Spinal cord injuries are typically categorized as either complete or incomplete. Complete spinal cord injuries are the severer of the two. These injuries may cause a complete loss of motor skills or sensations below the site of the injury. Incomplete spinal cord injuries are not as severe, but can still lead to years of pain and suffering. They are the cause of a variety of problems, including compromised motor skills and bodily functions below the injury.. Sadly, the negligent actions of a careless medical professional can lead to these life-altering injuries. If this is the case in your situation, an attorney at the Hankey Law Office, may be able to help you to seek justice and fair compensation. ...
WXXIs national health care series Second Opinion tells two personal stories about devastating spinal cord injuries.. Dr. Brad Berk, the CEO of the University of Rochester Medical Center shares the story of the bicycle accident that left him in a wheelchair, and Charlie Durkee also joins in the conversation, as he shares the trials he has faced since his accident which left him paralyzed at the age of 22. Second Opinion: Spinal Cord Injury airs Wednesday, January 19 at 3 p.m. on WXXI-TV/HD (DT21.1/cable 1011 and 11).. Each year, more than 11,000 Americans will experience a similar injury, often causing permanent disability or paralysis. Advances in research may someday make the repair of spinal cord injuries possible, but current treatments and rehabilitation allow many people to lead productive, independent lives.. Dr. Berk joins panelists Dr. David Chen, Medical Director of the Spinal Cord Injury Program at the Rehabilitation Institute of Chicago and Dr. Paul Maurer, a neurosurgeon at the ...
Spinal cord injury can be completely devastating and severely impacts the lives of everyone that surrounds the injured individual. Michael Lamson has practiced personal injury law for over 35 years and represents clients who have experienced spinal cord injury.. Spinal cord injury occurs when a body has sustained damage to the spinal column, causing paralysis, loss of motor control and sensation. A person with spinal injury can be paraplegic with loss of sensation/motor control of legs, or quadriplegic with loss of sensation/control of all limbs. Not only is a spinal cord injury permanently disabling, it also makes a person even more susceptible to serious health problems due to lack of control of essential body functions like breathing, control of bladder, body temperature and more.. Call Michael Lamson if you have experienced a spinal cord injury as the result of the following:. ...
Task-Specificity for Incomplete Spinal Cord Injury. T. George Hornby PhD, Principal Investigator. This study is a randomized controlled trial for patients with a motor incomplete spinal cord injury directed towards understanding the relative contributions of specificity of training to improve locomotor function. We are recruiting ambulatory individuals with a motor incomplete SCI of at least 1 year duration.. Contact: Chris Henderson. Email: [email protected] Phone: 317-329-2353. ...
The aim of this study was to determine the efficacy and the effects of functional electrical stimulated cycling (FES cycling) in patients with spinal cord injury during their rehabilitation in a special acute care unit. Thirty patients [10 with American Spinal Injury Association Impairment Scale (AIS) grade A, three with AIS grade B, 15 with AIS grade C, two with AIS grade D] aged 44±15.5 years and 2 (median) (interquartile range, 1.0-4.25) months after spinal cord injury were included in the study. The patients participated in a 20-min FES-cycling program 2 days per week for 4 weeks during their acute inpatient rehabilitation ...
Spinal cord injuries generally result from trauma to the spinal column. The force can fracture or dislocate vertebrae - the bone segments in the back. And spinal cord tissue is damaged. A wide range of symptoms can be experienced, depending on the severity and location. Some spinal injury victims can expect full recovery with rehabilitation. Other injuries are more serious and can result in paralysis. In either case, rehabilitation is important to treatment and repair. In addition to limiting mobility, spinal cord injuries can result in additional issues, such as respiratory problems. HealthSouth has all the resources needed for specialized spinal cord injury care. The team approach puts the right experts and therapies together for the best possible outcome, focused on:. ...
United Spinal Association and National Spinal Cord Injury Association (NSCIA), two leading nonprofits with more than 125 years of combined service to the
The spinal cord is a fibrous structure, which is housed in the bony confines of the spinal column. Spinal cord injury occurs almost exclusively as the result of major trauma. Motor vehicle accidents, diving injuries, falls, and gunshot wounds make up a large portion of these incidents. Review the neck injury: (general) section for important information concerning spinal cord injury. The spinal cord is protected by the bone structure, known as vertebrae. The vertebrae are stacked on top of one another and fastened by ligaments. Muscles overlay this framework and provide dynamic structural support. Common symptoms of spinal cord injury range from numbness, tingling, or weakness in an extremity, to total inability to move (paralysis). Severe spinal cord injury can result in respiratory arrest, particularly when the cord damage is high up toward the neck. The higher up the cord damage, the more it will involve ALL the extremities and interfere with normal bodily functions, such as blood ...
Mesenchymal Stem Cells in the Treatment of Patients with Chronic Spinal Cord Injury (ASIA A) with Residual Electrophysiological Function. Vocational Decision-Making and Rehabilitation Following Paediatric Traumatic Spinal Cord Injury: An Illustrative Case Study Analysis. Articles related to spinal cord injury are open access to read here.
The mission of The Spinal Cord Injury Zone is to archive important Spinal Cord Injury News and Spinal Cord Injury Information for education and awareness. The Spinal Cord Injury Zone website is a not-for-profit Spinal Cord Injury educational Knowledge Base ...
A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrowth of severed axons in the adult CNS, at present, the approaches by which this can be accomplished after complete cord transection are quite limited. In the present study, we modified a classic peripheral nerve grafting technique with the use of chondroitinase to facilitate the regeneration of axons across and beyond an extensive thoracic spinal cord transection lesion in adult rats. The novel combination treatment allows for remarkably lengthy regeneration of certain subtypes of brainstem and propriospinal axons across the injury site and is followed by markedly improved urinary function. Our studies provide evidence that an enhanced nerve grafting strategy represents a potential regenerative treatment after severe spinal cord injury. ...
Research suggests that combining therapies could result in important gains in restoring function and improving quality of life in persons with spinal cord injury (SCI). Locomotor training is an activity-dependent rehabilitation therapy that provides repetitive stepping facilitated by manual assistance and body weight support on a treadmill. Recent studies report improvements in walking and standing in individuals with motor incomplete SCI that have undergone intensive standardized locomotor training therapy. Extended release dalfampridine (also known as fampridine or 4-aminopyridine [4-AP]) is a broad spectrum potassium channel blocker that has been shown in animal studies to increase conduction of action potentials in demyelinated axons. Dalfampridine was recently approved by the U.S. Food and Drug Administration (FDA) as a treatment to improve walking in persons with multiple sclerosis (MS). Demyelination is also a prominent feature of incomplete SCI that contributes to the clinical ...
National Spinal Cord Injury Lawyers 40 Years of Experience Over $3 Billion Won for Our Clients Thousands of Lives Changed Spinal cord injuries are devastating injuries that can have lifelong effects. They require extensive medical care and can even lead to death. If you or someone you love has suffered a spinal cord injury because … Spinal Cord Injuries Read More
We specialize in the treatment of pediatric spinal cord injuries and dysfunction, including spina bifida; traumatic, complete and incomplete spinal cord injury; tethered cord; and more.
TY - JOUR. T1 - Effect of exercise on disorders of carbohydrate and lipid metabolism in adults with traumatic spinal cord injury. T2 - Systematic review of the evidence. AU - Carlson, Kathleen F.. AU - Wilt, Timothy J. AU - Taylor, Brent C. AU - Goldish, Gary D.. AU - Niewoehner, Catherine B. AU - Shamliyan, Tatyana A.. AU - Kane, Robert L. PY - 2009. Y1 - 2009. N2 - Background/Objective: Carbohydrate and lipid metabolism disorders may affect adults with spinal cord injuries (SCIs) differently than able-bodied individuals because of reduced physical activity in the SCI population. The objective of this study was to conduct a systematic review to determine the effectiveness of exercise to improve carbohydrate and lipid metabolism disorders in adults with chronic SCI. Methods: Studies were identified in MEDLINE (1996-2008), Cochrane Library, bibliographies of identified articles, and expert recommendations. English language articles were included if they evaluated adults with chronic SCI; ...
TY - JOUR. T1 - Methylprednisolone reduces excitatory amino acid release following experimental spinal cord injury. AU - Liu, Danxia. AU - McAdoo, David J.. PY - 1993/4/23. Y1 - 1993/4/23. N2 - Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory amino acids following experimental spinal cord injury in rats.. AB - Administration of methylprednisolone within several hours after injury to the spinal cord has been shown to reduce subsequent impairment in humans and experimental animals. Secondary damage following initial trauma is probably caused in part by the toxicity of released excitatory amino acids. We demonstrate here that methylprednisolone reduces the release of excitatory ...
TY - JOUR. T1 - Acute spinal cord injury. AU - Kirke Rogers, W.. AU - Todd, Michael. N1 - Publisher Copyright: © 2015 Elsevier Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Acute spinal cord injury (SCI) is a devastating event with high mortality and, among survivors, a high degree of morbidity due to both motor and sensory deficits. The damage that occurs with a SCI is recognized to be pathophysiologically biphasic: the initial insult to neural tissue can be followed by a secondary process of progressive ischemia that may worsen the severity of dysfunction. The extent of this secondary insult is potentially modifiable, and a variety of interventions have been studied in an attempt to improve motor and sensory outcomes. What follows is a brief review of some such procedural and pharmacologic interventions, including early decompressive surgery, use of methylprednisolone, and blood pressure and respiratory management, which have been ...
TY - JOUR. T1 - Prevention of venous thromboembolism in patients with spinal cord injury. T2 - Effects of sequential pneumatic compression and heparin. AU - Winemiller, Mark H.. AU - Stolp-Smith, Kathryn A.. AU - Silverstein, Marc D.. AU - Therneau, Terry M.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Objective: To estimate the incidence of and risk factors for venous thromboembolism in patients with acute traumatic spinal cord injury (SCI) and evaluate the effectiveness of sequential pneumatic compression devices (SCD), gradient elastic stockings (GES), and heparin in preventing thromboembolism. Design: Prentices case-cohort design. Setting: All patients admitted to our hospital between 1976 and 1995 with acute traumatic SCI. Main outcome measures: Demographic characteristics, venous thromboembolism risk factors, methods of surveillance and prophylaxis, and thromboembolic events during the first 6 weeks following injury. Results: Venous thromboembolism occurred in 84 of 428 patients (19.6%). Venous ...
The Acute Spinal Injury Unit, relocated from Conradie Hospital to Groote Schuur Hospital in mid-2003, admitted 162 patients in the first year of its existence. A large number of these injuries were the result of interpersonal violence, particularly gunshot wounds. Aim. To review patients with gunshot injuries to the spine, with reference to neurological injury, associated injuries, need for surgery and complications. Methods. A comprehensive database is maintained to collect data on all spinal injury admissions. These data, as well as case notes and X-rays, were reviewed for all gunshot spine patients admitted to the Acute Spinal Injury Unit over a year. Forty-nine patients were identified. Thirty-eight were male and 11 female with an average age of 27.5 years (range 15 - 51 ± 8.53). The average stay in the acute unit was 30 (4 - 109 ± 28) days. Results. The spinal injury was complete in 38 and incomplete in 8, with 3 having no neurological deficit. The level was cervical in 13, thoracic in 24 ...
A spinal cord injury can be a distressing occurrence that can have a severely detrimental effect on a persons life. Even relatively minor cases can cause a great deal of pain and discomfort, preventing movement and impairing the ability to perform even the simplest of tasks. With more severe cases, the effects can be especially devastating physically and financially. Spinal cord injuries are especially difficult and costly to treat, and the situation can be worsened by the inability to work or make a living. If the injury is caused by another party, the injured party may be eligible to file a claim for monetary compensation. This is where our lawyers can help. We have a staff of highly qualified legal professionals that have extensive experience dealing with spinal cord injury claims. With our assistance, you can get the legal service that you need to get the compensation you deserve. ...
Acute spinal cord injury (SCI) is when the spinal cord is damaged from an accident or other situation. An SCI may be a bruise (contusion), a partial tear, or a complete tear (transection) in the spinal cord.
Acute spinal cord injury (SCI) is when the spinal cord is damaged from an accident or other situation. An SCI may be a bruise (contusion), a partial tear, or a complete tear (transection) in the spinal cord.
Using the DPC database, we identified patients who had an emergency admission to the participating hospitals with a diagnosis of cervical SCI (ICD-10 code, S141) between July and December, 2007-2009. Patients who were transferred from other hospitals were excluded. Although we were unable to confirm the presence of a neurological deficit in each patient, miscoding is relatively unlikely because the DPC data are coded by physicians and subjected to an audit. The list of drugs used during hospitalisation was reviewed for each patient, and we identified patients who started high-dose methylprednisolone treatment for acute cervical SCI at admission and received a total of ≥5000 mg methylprednisolone infusion. In Japan, many elderly patients who sustain a cervical SCI are lean. For a 40 kg person, the total dosage amounted to 6168 mg in the NASCIS-2 protocol. Therefore, we set a cut-off value of 5000 mg. As a control group, we identified cervical SCI patients who did not receive methylprednisolone, ...
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High-dose methylprednisolone increases risks of complications in acute spinal cord injury I found this blog article in the Spinal News iPhone app. For more information about the Spinal News app and to download, click here:
With support from a Fiscal Year 2014 (FY14) Spinal Cord Injury Research Program (SCIRP) Clinical Trial Award, Dr. Wilson Z. Ray and his team sought to establish and validate clinical guidelines on the use of nerve transfers to improve upper extremity function in patients with cervical SCI. To achieve this, cervical SCI patients with no hand function enrolled in Dr. Rays trial and underwent nerve transfer surgery, followed by post-operative therapy. After successful surgery and completion of hand therapy, all 19 patients experienced improvements in hand and upper limb function. Notably, two patients with C4 SCIs experienced an increase in muscle power from 0 to 4 on the Medical Research Council (MRC) scale on the side that received nerve transfer. The MRC scale rates muscle power when subjected to normal resistance. A 0 is no muscle activation and no range of motion and 5 is full activation and full range of motion. Despite hand function not being completely restored for these patients, both ...
TY - JOUR. T1 - Alterations in recovery from spinal cord injury in rats treated with recombinant human bone morphogenetic protein-2 for posterolateral arthrodesis. AU - Dmitriev, Anton E.. AU - Castner, Suzanne. AU - Lehman, Ronald A.. AU - Ling, Geoffrey S.F.. AU - Symes, Aviva J.. N1 - Funding Information: This study was funded by a grant from the translational research program of the Blast Spinal Cord Injury Program, U.S. Department of Defense. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2011/8/17. Y1 - 2011/8/17. N2 - Background: Treatment of trauma-related spinal instability with use of recombinant human bonemorphogenetic protein-2 (rhBMP-2) may appear as a viable option, but little is known of the direct effects of rhBMP-2 on the injured spinal cord. In the current study, we investigated the acute and long-term effects of using rhBMP-2 in the posterolateral spine at the level of a spinal cord injury in rats. Methods: Fifty-two rats underwent a T10 dorsal hemisection ...
Having a spinal cord injury can effect every aspect of your life. Learn what a spinal cord injury is and how a spinal cord injury lawyer can help you.
Does physical exercise improve arterial structure and function in spinal cord-injured individuals? And response to letter to the editor by Jan T. Groothuis et al ...
Compared with our knowledge concerning the responses to exercise of able-bodied athletes there is relatively little known about the exercise responses of athletes who have a spinal cord injury (SCI). The purpose of this thesis was to examine the physiological characteristics of endurance trained wheelchair athletes; to assess the importance of various physiological factors to the endurance performance of wheelchair athletes; to describe and examine the physiological and metabolic responses and performances of wheelchair athletes to endurance and brief high intensity exercise; and to assess the influence of level of SCI or wheelchair racing class on these responses to exercise. The mean peak oxygen uptake (V02 pk) achieved by the group of 27 wheelchair athletes during wheelchair treadmill exercise was 2.11 ±0.53 I. min-1. When the athletes were grouped according to the paralympic racing classification system (TK2; TK3; TK4) the V02 pk values were 1.28 ±0.16 l. min-1,2.10 ±0.43 I. min-1 and ...
Supplemental_materials - The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review
NextSteps Chicago is a Spinal Cord Injury Rehabilitation Center, providing treatment and exercise therapy to help SCI clients regain function.
Our unique spinal cord injury rehabilitation program helps patients regain their independence and reach their maximum potential, letting their family worry less.
TY - JOUR. T1 - Low-Intensity Wheelchair Training in Inactive People with Long-Term Spinal Cord Injury. T2 - A Randomized Controlled Trial on Propulsion Technique. AU - van der Scheer, Jan W.. AU - de Groot, Sonja. AU - Vegter, Riemer J. K.. AU - Hartog, Johanneke. AU - Tepper, Marga. AU - Slootman, Hans. AU - Veeger, DirkJan H. E. J.. AU - van der Woude, Lucas H. V.. AU - ALLRISC Grp. PY - 2015/11. Y1 - 2015/11. N2 - Objective The objective of this study was to investigate the effects of a low-intensity wheelchair training on propulsion technique in inactive people with long-term spinal cord injury.Design Participants in this multicenter nonblinded randomized controlled trial were inactive manual wheelchair users with spinal cord injury for at least 10 yrs (N = 29), allocated to exercise (n = 14) or no exercise. The 16-wk training consisted of wheelchair treadmill propulsion at 30%-40% heart rate reserve or equivalent in rate of perceived exertion, twice a week, 30 mins per session. Propulsion ...
Spinal cord injury (SCI) remains the most common cause of paralysis, and there are no effective therapies for SCI patients. Neural stem cell (NSC)-derived exosomes can attenuate apoptosis and neuroinflammation after traumatic spinal cord injury, but the mechanisms underlying these effects remain unclear. Here, we examined the efficacy of miRNAs isolated from exosomes as treatments for SCI and characterized their mechanisms of action. Furthermore, we evaluated the effects of exosomes formed in the presence of insulin growth factor-1 (IFG-1, IGF-Exo), which promotes neural proliferation and regeneration, as well as normal exosomes (Nor-Exo) and compared control and H2O2-treated groups both in vitro and in vivo. Using microRNA sequencing and qRT-PCR, we identified miR-219a-2-3p, levels of which were higher in the IGF-Exo than Nor-Exo group and played crucial anti-inflammatory and anti-apoptosis roles. Additional experiments revealed that IGF-Exo inhibits
The University of Vermont Medical Center specializes in spinal cord injury and treats people with most levels of injury, including some with a dual diagnosis of a spinal cord injury and traumatic brain injury.
Exertional hypotension in thoracic spinal cord injury: case report.: Exertional hypotension is well described in quadraplegics, but there are few descriptions o
Approximately 250,000 - 400,000 people are currently living with spinal cord injuries in the United States, and about 11,000 new spinal cord injuries occur each year (30 injuries per day). A staggering 42 percent of these annual injuries are caused by motor vehicle accidents, and another 22 percent result from traumatic falls.. Sustaining a spinal cord injury can severely affect a persons quality of life, both physically and emotionally. A spinal cord injury often requires rehabilitation therapy, medication, surgery, prosthesis, and the use of a wheelchair and/or computer device to assist with daily routines. The costs of these treatments and technologies can be exorbitant, which is why it is so important to seek damages for any and all medical expenses that will arise throughout the victims lifetime with the help of a personal injury lawyer.. If you are a Kansas or Missouri resident who has sustained a spinal cord injury as a result of someone elses negligence, you may be eligible for ...
by Deanna Power About half a million people suffer spinal cord injuries each year, often due to car accidents. If you have sustained a spinal cord injury due to a traffic accident, you may be entitled to compensation through an auto insurance claim or a personal injury lawsuit. Personal Injury Claims and Recoverable Damages
The Rural Institute announces the funding of a new research project that explores how loneliness interacts with other factors to impact the mental and physical health of people with spinal cord injuries (SCI).. Loneliness and Its Relation to Health in People with Spinal Cord Injury is a three-year, national study funded by the Department of Defense.. This study represents the most comprehensive investigation of the impact of loneliness on the health of people with spinal cord injury conducted to date, says Dr. Rosemary Hughes, Senior Research Scientist at the Rural Institute. Hughes is partnering with Baylor College of Medicine, TIRR Memorial Hermann, and a Community Advisory Board of veterans and other adults with SCI in this research project. The team hopes to involve more than 350 research volunteers with SCI to contribute to the success of the study.. Our findings will have the potential to improve the understanding of factors associated with loneliness, support health care providers in ...
TY - JOUR. T1 - Meaning and components of quality of life among individuals with spinal cord injury in Yogyakarta Province, Indonesia. AU - Ferdiana, A.. AU - Post, M.W.M.. AU - King, N.. AU - Bültmann, U.. AU - Van Der Klink, J.J.L.. PY - 2018. Y1 - 2018. N2 - Purpose: Knowledge on the meaning of quality of life in individuals with spinal cord injury in developing countries is limited. This study aims to explore the meaning and components of quality of life for individuals with spinal cord injury in a rural area in Indonesia.Method: Data were obtained through semi-structured interviews with 12 individuals with paraplegia (8 males, 4 females) aged 24-67 years. Thematic analysis was used to identify themes that constitute meaning and components of quality of life.Results: Quality of life was not an easily understood concept, while life satisfaction and happiness were. Life satisfaction was associated with a persons feeling when achieving goals or dreams and related to fulfillment of needs. ...
Looking for an attorney in West Palm Beach, Florida to help with a Spinal Cord Injuries claim? Our directory enables you to easily compare the services and qualifications of West Palm Beach Spinal Cord Injuries lawyers near you.
Spinal cord injury lawyers in La Mesa at Liljegren Law Group can help if you have suffered a spinal cord injury. Call for a free consultation.
A. S. Burns et al., Type and Timing of Rehabilitation Following Acute and Subacute Spinal Cord Injury: A Systematic Review, Glob. Spine J., vol. 7, no. 3_suppl, p. 175S-194S, Sep. 2017. J. van Tuijl, Y. Janssen-Potten, and H. Seelen, Evaluation of upper extremity motor function tests in tetraplegics, Spinal Cord, vol. 40, no. 2, pp. 51-64, Feb. 2002. Paralyzed Veterans of America Consortium for Spinal Cord Medicine, Preservation of upper limb function following spinal cord injury: a clinical practice guideline for health-care professionals., J. Spinal Cord Med., vol. 28, no. 5, pp. 434-470, Sep. 2005. R. Rupp, S. C. Kleih, R. Leeb, J. del R. Millan, A. Kübler, and G. R. Müller-Putz, Brain-Computer Interfaces and Assistive Technology, in Brain-Computer-Interfaces in their ethical, social and cultural contexts, vol. 12, Dordrecht: Springer Netherlands, 2014, pp. ...
Our team of rehabilitation specialists develops individualized treatment programs for spinal cord injury patients to help them regain strength and movement to achieve maximum mobility and independence.
RSCBF - Regional Spinal Cord Blood Flow. Looking for abbreviations of RSCBF? It is Regional Spinal Cord Blood Flow. Regional Spinal Cord Blood Flow listed as RSCBF
In order to develop and maintain quality services for individuals with spinal cord injuries, rehabilitation staff and programs MUST specialize in treating SCI. This expertise is best acquired and maintained when staff members treat people with SCI on a regular basis. High quality rehabilitation programs are often located in facilities devoted exclusively to providing rehabilitation services, or in hospitals with designated SCI units. In-patient SCI rehabilitation programs have features which distinguish them from the hospital programs where most people receive initial treatment. Rehabilitation programs are designed to serve people with a wide variety of skills and must address complex social and community issues. A rehabilitation team comprised of specialized medical personnel is used to accomplish these goals. Teams should include social workers, occupational and physical therapists, recreational therapists, rehabilitation nurses, rehabilitation psychologists, vocational counselors, ...
Spinal cord injuries can be devastating. Contact our spinal cord injury lawyers if you or a loved one has been injured. Free consultation.
Commemorating International Yoga Day this year, Indian Spinal Injuries Centre, New Delhi today organized a first-of-its-kind wheelchair yoga session at the hospital premises, where 20 participants from different wakes of life took part. The innovative session was conceptualized and supervised by Ms. Pragya Ghildial Senior Yoga Therapist, Indian Spinal Injuries Centre, VasantKunj, Delhi.
TY - GEN. T1 - Closed-Loop Bladder Neuromodulation Therapy in Spinal Cord Injury Rat Model. AU - Raczkowska, Marlena N.. AU - Peh, Wendy Y.X.. AU - Teh, Yuni. AU - Alam, Monzurul. AU - Yen, Shih Cheng. AU - Thakor, Nitish V.. N1 - Funding Information: This work was funded by the National Research Foundation in Singapore (NRF-CRP10-2012-01) and the GSK Bioelectronics Innovation Challenge (code 100042784). 1Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore (NUS), Singapore 2 School of Medicine, Johns Hopkins University, Baltimore, USA † These authors share senior authorship. Publisher Copyright: © 2019 IEEE. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/5/16. Y1 - 2019/5/16. N2 - Poor bladder management is a common and potentially life-threatening dysfunction among spinal cord injury (SCI) patients. In this condition, sensation from the bladder and voluntary control of micturition are lost, which might result in high post-void ...
Erin Jones, UCF and Orlando Healths neurologic residency coordinator and UCF Doctor of Physical Therapy program alumni and clinical faculty, is part of two rehabilitation teams at Orlando Health that received multiple grants for the care of individuals with spinal cord injury.. The first team received a $20,000 grant from the Craig Neilsen Foundation to assist with the living expenses and medical supplies of 30 individuals with spinal cord injury in the Orlando area. The team also includes spinal cord network coordinator Bob Melia from Orlando Health.. The second team received a $16,000 grant from the Christopher Reeve Foundation to help with a free clinic run by a physical therapist specializing in wheelchair seating and mobility to prevent secondary complications from immobility. The team of spinal cord rehabilitation experts also include residency faculty and UCF DPT alumna and clinical faculty, Kristen Cezat, as well as Bob Melia, Orlando Health.. ...
Our past researches suggested that L. barbarum exhibits direct neuroprotective and immune regulatory effects on the central nervous system, which are highly related to the events involved in the spinal cord injury, but not yet been investigated. Immune responses play an important role in the development of the pathology after secondary injury, particularly the M1 and M2 types of macrophage, on which special emphasis was laid in this study. In our previous studies L. barbarum was administrated orally from 7 days before the injury to ensure a stabilized concentration in the blood. For clinical application, L. barbarum can only be administered after the injury. Therefore, both pre-injury and post-injury administration protocols were compared. In vivo and in vitro studies were conducted and analyzed immunohistochemically, including Western blotting. The lesion size in the pre-treated group was much larger than that in the post-treated group. To explain this difference, we first studied the effect of L.
Injuries to the head and spinal cord have the potential to cause serious health problems that last for the long term. Brain injuries, for their part, often lead to problems with memory, impairments in ones visual perceptional skills, reduced concentration, nausea, issues with motivation and an impaired ability to process information, among other issues.. Spinal cord injuries also tend to be quite serious in nature, with injured individuals often dealing with chronic pain, nerve damage, loss of movement or sensation, exaggerated reflex actions and loss of bladder control. In the most severe cases, injured parties may suffer from paralysis and other permanent disabilities.. Brain and spinal cord injuries have the potential to drastically reduce your overall quality of life, leaving you unable to earn a living and enjoy certain activities or hobbies. Any compensation you seek from the at-fault party or an insurance company should account for the long-term costs of treating your injuries-something ...
TY - JOUR. T1 - Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. AU - Seki, Satoshi. AU - Sasaki, Katsumi. AU - Igawa, Yasuhiko. AU - Nishizawa, Osamu. AU - Chancellor, Michael B.. AU - De Groat, William C.. AU - Yoshimura, Naoki. PY - 2004/1. Y1 - 2004/1. N2 - Purpose: We investigated the effects of intrathecal application of nerve growth factor (NGF) antibodies (NGF-Abs) and desensitization of C-fiber afferent pathways by capsaicin treatment on detrusor-sphincter dyssynergia (DSD) after spinal cord injury (SCI). Materials and Methods: In adult female rats SCI was induced by complete transection of the spinal cord at Th8 to 9. Ten days after spinalization vehicle or NGF-Ab (10 μg daily) was continuously administered at the level of the L6-S1 spinal cord through an implanted intrathecal catheter connected to an osmotic pump for 2 weeks. Another group of spinalized rats was treated with capsaicin ...
Medical News Today reports that Spinal Injuries Are More Frequent in Children With Seat Belt Injuries. If the link to the article is inactive, you can click here to access the Adobe Acrobat version of the article.. The article states, in part, that Ill-fitting seat belts raise the risk of serious injury to children involved in car accidents. And seat belt injuries should alert physicians to look for signs of more serious consequences, particularly spinal cord injury, which is not always immediately apparent. Unless physicians are diligent, spinal-cord injuries are hard to diagnose in children. In the event of a car accident, seat belt injuries such as bruising and tenderness should warrant a search for other injuries, including spinal-cord injury, vertebral fractures and intra-abdominal injuries. If spinal-cord injury is missed or not diagnosed early, the consequences can be devastating, said Harsh Grewal, M.D., in a report published in August issue of the Journal of Spinal Cord Medicine. ...
TY - JOUR. T1 - Prehospital Protocols Reducing Long Spinal Board Use Are Not Associated with a Change in Incidence of Spinal Cord Injury. AU - Castro-Marin, Franco. AU - Gaither, Joshua B.. AU - Rice, Amber D.. AU - N. Blust, Robyn. AU - Chikani, Vatsal. AU - Vossbrink, Anne. AU - Bobrow, Bentley J.. N1 - Publisher Copyright: © 2019, © 2019 National Association of EMS Physicians. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/5/3. Y1 - 2020/5/3. N2 - Introduction: Many emergency medical services (EMS) agencies have de-emphasized or eliminated the use of long spinal boards (LSB) for patients with possible spinal injury. We sought to determine if implementation of spinal motion restriction (SMR) protocols, which reduce LSB use, was associated with an increase in spinal cord injury (SCI). Methods: This retrospective observational study includes EMS encounters from January 1, 2013 to December 31, 2015 submitted by SMR-adopting ground-based agencies to a state EMS database ...
Spinal cord injuries are one of the most common traumas brought into veterinary hospitals.[86] Spinal injuries occur in two ... Brain and spinal cord injury[edit]. Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons ... Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury.[21][22][23] ... 2012). "Functional recovery after spinal cord injury in dogs treated with a combination of Matrigel and neural-induced adipose- ...
Spinal cord injury. *Multiple sclerosis. *Use of SSRI antidepressants[19]. *Use (or previous use) of antidopaminergic ...
Spinal cord injury. During spinal shock, the bladder is flaccid and unresponsive. It becomes overfilled, and urine dribbles ... by sympathetic nervous system fibers from the lumbar spinal cord and parasympathetic fibers from the sacral spinal cord.[4] ... a discoordination between the bladder and external urethral sphincter as a result of brain or spinal cord injury ... Bladder afferent signals ascend the spinal cord to the periaqueductal gray, where they project both to the pontine micturition ...
Spinal cord injury. *Multiple sclerosis. *Use of SSRI antidepressants or having used SSRI antidepressants in the past.[19] ...
Spinal Cord Injuries: Comprehensive Management and Research. Blackwell Science. .mw-parser-output cite.citation{font-style: ... "International Spinal Cord Society (ISCoS)). Retrieved 22 August 2012.. *^ Bailey, Steve (2008). Athlete First: A history of the ... Guttmann became the first editor of the journal, Paraplegia (now named Spinal Cord).[18] He suffered a heart attack in October ... Silver, John Russell (2003). History of the Treatment of Spinal Injuries. Springer. ISBN 978-0-306-48032-4.. ...
Disordered Cardiovascular Control After Spinal Cord Injury". In Verhaagen, Joost; McDonald, John W. (eds.). Spinal Cord Injury ... normally supported by the sympathetic nervous system due to injury to the central nervous system especially spinal cord injury ...
... spinal cord injury." Located in Miami, Florida, the University of Miami Medical Center includes Jackson Memorial Hospital and ...
Shriners Hospital for Children, Philadelphia (orthopaedics, spinal cord injury). *Transitional Infant Care (NICU Hospital), ... Shriners Hospitals for Children, Chicago (orthopaedics, spinal cord injury, cleft lip and palate) ...
stroke, multiple sclerosis, spinal cord injury. *complex neuropathic disorders *complex regional pain syndromes [CRPSs][5] ... C fibers synapse to second-order projection neurons in the spinal cord at the upper laminae of the dorsal horn in the ... C fibers cause central sensitization of the dorsal horn in the spinal cord in response to their hyperactivity.[5] The mechanism ... quadrant of the contralateral half of the spinal cord, forming the spinothalamic tract.[1] The spinothalamic tract is the main ...
"Spinal cord injury Causes - Mayo Clinic". Retrieved July 16, 2017. "Bridgestone Motorcycle Tires". www. ... Automotive and motorcycle accidents together are the leading cause of spinal cord injuries, about 35% percent. Tire issues such ... Automotive and motorcycle accidents together are the leading cause of spinal cord injuries, about 35% percent; this can include ... more minor injuries to the spinal cord up to more severe cases such paraplegic (2) or quad (4) plegic cases. Paralysis injuries ...
"Eric Westacott Foundation Raises Over $30,000 to Help Young Quadriplegic Boy , News". Spinal Cord Injury Zone. August 11, 2009 ... He suffered various injuries in the accident, including a severe spinal injury, severe neck injuries, and brain trauma, was ...
Spinal Cord Injury BC. Winter 2013. p. 30. "Duncan Campbell". BC Sports Hall of Fame. Retrieved 4 November 2019. "Rugby should ...
Wikstrom sustained an injury to his spinal cord while swimming in the Mississippi River and became a high-level quadriplegic at ... ISBN 978-0-9680667-8-2. "A limit, not an end". Spinal Cord Injury Zone. March 27, 2004 Home & Garden , A Charmed Corner , ...
Spinal cord injuries are classified as complete and incomplete by the American Spinal Injury Association (ASIA) classification ... Loss of upper-limb function in patients with following a spinal cord injury is a major barrier to regain autonomy. The ... Transfer of the brachio radialis to improve wrist extension in high spinal cord injury. Freehafer AA, Mast WA., J Bone Joint ... Tendons transfers to improve grasp after injuries of the cervical spinal cord.Freehafer AA, Vonhaam E, Allen V., J Bone Joint ...
Taylor, R. G.; Gleave, J. R. W. (1957). "Incomplete Spinal Cord Injuries". The Journal of Bone and Joint Surgery. British ... This is consistent with other work showing remote spinal cord injuries from ballistic impacts. Roberts et al. present both ... that a focusing effect from concave surfaces can concentrate the pressure wave on the spinal cord producing significant injury ... Distant injuries away from the main track in high velocity missile injuries are very important and almost always present in all ...
"Spinal Cord Injury Charity". Retrieved 31 August 2012. "Coulthard honoured with MBE". Formula One. 12 June 2010. Archived from ... a charity dedicated to raising awareness of spinal cord injuries. He was unable to finish the race, when his car was hit by ... Coulthard is an ambassador for the spinal injuries charity Wings For Life. Coulthard was appointed Member of the Order of the ... He did not return to the series after suffering a leg injury in a Formula Vauxhall race at Spa-Francorchamps. For 1991, ...
In people with a past history of spinal cord injuries *Autonomic dysreflexia ...
This pathologic phenomenon can also occur after brain injury and spinal cord injury. Within minutes after spinal cord injury, ... Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure ... "Mechanisms of chronic central neuropathic pain after spinal cord injury". Brain Res Rev. 60 (1): 202-13. doi:10.1016/j. ... "Na+-K+-ATPase inhibition and depolarization induce glutamate release via reverse Na+-dependent transport in spinal cord white ...
"IndyCar driver Robert Wickens has surgery; spinal cord injury still unknown". Indy Car. August 31, 2018. Retrieved September 1 ... "IndyCar driver Robert Wickens has surgery; spinal cord injury still unknown". ESPN. August 24, 2018. Retrieved August 25, 2018 ... Wickens issued a further statement clarifying that he was hopeful to be able to walk again, due to his spinal cord being ... On September 7, 2018, the Wickens family announced the full extent of Robert's injuries: a thoracic spinal fracture, a neck ...
CS1 maint: discouraged parameter (link) "Sam Schmidt Paralysis Foundation". National Spinal Cord Injury Association. Retrieved ...
Phil Klebine; Linda Lindsey (May 2007). "Sexual Function for Men with Spinal Cord Injury". Spinal Cord Injury Information ... Suh, Donald; Yang, Claire; Clowers, Diane (2003). "Nocturnal penile tumescence and effects of complete spinal cord injury: ... 2003) recognizes that in particular the spinal regulation of the cervical cord is critical for nocturnal erectile activity. ... of the spinal cord. A full bladder is known to mildly stimulate nerves in the same region. The possibility of a full bladder ...
Spinal cord injuries (SCIs) cause damage to the nervous system, which can result in neurological disfunction. The main barrier ... Vercelli A, Boido M (2015-01-01). "Chapter 15 - Spinal Cord Injury". In Zigmond MJ, Rowland LP, Coyle JR (eds.). Neurobiology ... Kubinová S, Syková E (January 2010). "Nanotechnology for treatment of stroke and spinal cord injury". Nanomedicine. 5 (1): 99- ... research has demonstrated that nano scaffolds may be an effective tool for repairing spinal cord injuries (SCIs). Such studies ...
On July 3, 2009, Fedor suffered a complete spinal cord injury (SCI) when he broke his neck after he dove off a cottage pier ... "Spinal Cord Injury Treatment The MetroHealth System". "Weighing the Risks of a New Implanted Device". Global ... The book was published by Coyote Crest in July 2019 on the tenth anniversary of his spinal cord injury. In 2011, Fedor founded ... Vanderhaven, Mimi (11 October 2018). "Life After Spinal Cord Injury". Kuntz, John (29 December 2012). " ...
"Spinal Cord Injury Hall Of Fame 2006 Nominees > Disability Activist Frederick Fay". National Spinal Cord Injury Association. ... At age 16, he sustained a cervical spinal cord injury, and started using a manual wheelchair for mobility. At 17, he launched ... He was also the leader of the National Paraplegia Foundation, now known as the United Spinal Association, and established and ... United Spinal Association. Retrieved 2019-02-26. Blaser, Arthur W. (September 2013). "Lives Worth Living: The Great Fight for ...
On July 12, 1998, Fisher suffered from a spinal cord injury after diving into shallow water near the Jersey Shore. She became a ... Parker-Hope, Tara (March 26, 2009). "Voices of Spinal Cord Injury". The New York Times blog. Retrieved May 3, 2010. "2011 MTHS ... "Discovery through Design's Rolling with Style Gala Adds a Whole New Spin to Fashion Week". National Spinal Cord Injury ... With other women, Fisher co-founded Discovery Through Design which has raised almost a million dollars for spinal cord research ...
Williams JA (2006). "Hedgehog and spinal cord injury". Expert Opinion on Therapeutic Targets. 9 (6): 1137-45. doi:10.1517/ ... On the other hand, mice mutants for SHH lack ventral spinal cord characteristics.In vitro blocking of SHH signaling using ... However, Gli2 mutant mice show abnormalities in the ventral spinal cord, with severe defects in the floor plate and ventral- ... It has been demonstrated that SHH attracts commissural axons at the ventral midline of the developing spinal cord. Specifically ...
Spinal Cord Injury & Disorders Services. "Spinal Cord Injury & Disorders Home". Archived from the original on April 27, 2008. ... Mental illness Traumatic brain injury Spinal cord injury Blindness Burns Amputation Terminal Illness/Injury Polytrauma Other ... spinal cord injuries, Parkinson's disease [1], and palliative care. The VHA has initiatives in place to provide a "seamless ... Retirees from military service, veterans with service-connected injuries or conditions rated by VA, and Purple Heart recipients ...
Role in spinal cord injuriesEdit. Traumatic spinal cord damage causes a permanent loss of motor and sensory functions in the ... Transplantation of OECs into the spinal cord has become a possible therapy for spinal cord damage and other neural diseases in ... Multiple studies have shown that OECs may assist in treating spinal cord injury (SCI) due to their regenerate properties in the ... 4 Role in spinal cord injuries *4.1 Peptide-modified gellan gum and OECs ...
... spinal cord, brain, and lung injury; injury due to ischemia in the heart, brain, kidney, and gut; and stress-induced central ... the overproduction of cyclopentenone prostaglandins by the brain has been suggested to contribute to the neuron injury observed ... the DP1 receptor coupled to Gs alpha subunit-dependent increases in cellular cAMP levels and the suppression of cell injury in ... DP2 receptor coupled to Gi alpha subunit-dependent depression of cellular cAMP levels and causing the potentiation cell injury ...
"Spinal Cord Injury Update (Fall 1997): Dancing on Wheels". Northwest Regional Spinal Cord Injury System. Retrieved July 14, ...
Studies have also shown that hypoxic air treatment may increase the recovery speed and endurance of spinal cord injuries. There ... Smith, Schevlin (Dec 29, 2013). "Hypoxia May Help Walking Endurance in Spinal Cord Injury Victims". Retrieved 4 November 2014. ...
In 1983, NKA (previously known as substance K or neuromedin L) was isolated from porcine spinal cord and was also found to ... Donkin JJ, Turner RJ, Hassan I, Vink R (2007). "Substance P in traumatic brain injury". Progress in Brain Research. 161: 97-109 ... It is found in the brain and spinal cord and is associated with inflammatory processes and pain. ... which is a local inflammatory response to certain types of infection or injury.[28] Unfortunately, the reasons why NK1RAs have ...
Amplification in the spinal cord may be another way of producing hyperalgesia. ... in rats after spinal nerve injury and inflammation". Eur. J. Pharmacol. 510 (3): 223-8. doi:10.1016/j.ejphar.2005.01.033. PMID ... "Regulation of proinflammatory cytokines gene expression by nociceptin/orphanin FQ in the spinal cord and the cultured ... nociceptive fibers in a pattern consistent with that from inflammation switches on a form of amplification in the spinal cord, ...
"Index of CD34+ Cells and Mononuclear Cells in the Bone Marrow of Spinal Cord Injury Patients of Different Age Groups: A ... "Functional Recovery of Spinal Cord Injury Following Application of Intralesional Bone Marrow Mononuclear Cells Embedded in ... "Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese ... "Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics". Exp Cell Res ...
A main focus of neuroscience is the biology and physiology of the human brain and spinal cord. Some related clinical ... Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or ... Neurological (consciousness, awareness, brain, vision, cranial nerves, spinal cord and peripheral nerves) ... Sports medicine deals with the treatment and prevention and rehabilitation of sports/exercise injuries such as muscle spasms, ...
Spinal cord injury. Nuclear Medicine. Paediatrics. Maternity. History. Founded. May 2015. Links. ... "The Queen Elizabeth National Spinal Injuries Unit". *^ "Institute of Neurosciences". NHS Greater ... Attached to the institute is The Queen Elizabeth National Spinal Unit for Scotland which provides a spinal injuries service to ...
However, the sensitivity of the DRE for injuries of the spinal cord, pelvis, and bowel is poor, and false positive and negative ... including traumatic spinal cord injuries;. *traditionally, the digital rectal examination (DRE) was considered an essential ... The examination is warranted in cases where urethral injury or penetrating rectal injury is suspected;[11][12] ...
The spinal cord is made up of bundles of these axons. Glial cells such as Schwann cells in the periphery or, within the cord ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... Spinal cord and other tissuesEdit. The pons in the brainstem is a specific region that consists of myelinated axons much like ... The medulla oblongata is at the start of the spinal cord and is composed mainly of neuron tissue enveloped in oligodendrocytes ...
The use of reclining wheelchairs is particularly common among people with spinal cord injuries such as quadriplegia.[10] ... A wheelchair is a chair with wheels, used when walking is difficult or impossible due to illness, injury, or disability. ... Unlike wheelchairs they are only suitable for below knee injuries to a single leg. The user rests the injured leg on the ...
Spinal cord injury. During spinal shock, the bladder is flaccid and unresponsive. It becomes overfilled, and urine dribbles ... by sympathetic nervous system fibers from the lumbar spinal cord and parasympathetic fibers from the sacral spinal cord.[4] ... a discoordination between the bladder and external urethral sphincter as a result of brain or spinal cord injury ... Bladder afferent signals ascend the spinal cord to the periaqueductal gray, where they project both to the pontine micturition ...
"Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury". ... In 2009, Brilliant Blue G was used in scientific experiments to treat spinal injuries in laboratory rats.[23] It acts by ... Two groups of injured rats were tested, with one group given the dye as a treatment for the spinal injuries and the other group ... "Blue M&Ms 'mend spinal injuries'". Telegraph. 2009-07-28. Retrieved 2010-01-19.. ...
"Injury. 41 (4): 329-334. doi:10.1016/j.injury.2009.08.007.. *^ Ringleb, Stacie I.; Dhakal, Ajaya; Anderson, Claude D.; Bawab, ... Head injury. *Spinal cord injury. Demographic. *Geriatric trauma. *Pediatric trauma. Complications. *Posttraumatic stress ... Many different knee injuries can happen. Three percent of knee injuries are acute traumatic patellar dislocations.[25] Because ... as injury to these structures may occur during the injury or during the reduction process.[3] Subsequent imaging studies are ...
After stroke or spinal cord injury in humans, spastic hypertonia (spastic paralysis) often develops, whereby the stretch reflex ... Mammalian muscle spindle showing typical position in a muscle (left), neuronal connections in spinal cord (middle) and expanded ... and transmit this signal to the spinal cord. The Ia afferent signals are transmitted monosynaptically to many alpha motor ... of the muscle spindle respond to both changes in muscle length and velocity and transmit this activity to the spinal cord in ...
TIA is now defined as a transient episode of neurologic dysfunction caused by focal brain, spinal cord, or retinal ischemia, ... Brain injury may still occur in a TIA lasting only a few minutes. Having a TIA is a risk factor for eventually having a stroke. ... Jun Chen, Zao C. Xu, Xiao-Ming Xu, Animal Models of Acute Neurological Injuries, Humana Press; 1 edition, ISBN 978-1-60327-184- ... 2002). "The effect of severe traumatic brain injury on the family". Journal of Trauma. 52 (6): 1121-4. doi:10.1097/00005373- ...
The impulses travel along the sensory axon to the spinal cord where they form several kinds of synapses: *Some of the branches ... Type IV: (very small) High threshold pain receptors that communicate injury. Type II and Type III mechanoreceptors in ... Some of the branches of the I-a axons synapse with inhibitory interneurons in the spinal cord. These, in turn, synapse with ...
vocal cords. Laryngopharyngeal reflux (LPR). Vocal fold nodule. Vocal fold paresis. Vocal cord dysfunction. epiglottis. ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... The goal of spinal manipulation therapy (SMT) is to improve thoracic mobility in an effort to reduce the work on the lungs ... GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (October 2016). "Global, regional, and national incidence, ...
"Index of CD34+ Cells and Mononuclear Cells in the Bone Marrow of Spinal Cord Injury Patients of Different Age Groups: A ... "A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved ... Stem-cell therapy shows promise for horse soft-tissue injury, disease». DVM Newsmagazine, 2008-05-01. Skatīts: 2008-06-12. ...
Nerve injury *Spinal cord injury. *Brachial plexus injury. *Peripheral nerve injury. *Sciatic nerve injury ... Injury from internal causes such as reperfusion injury. By locationEdit. *Wound, an injury in which skin is torn, cut or ... Illness and injuries during spaceflight. Injury severity scoreEdit. The injury severity score (ISS) is a medical score to ... Repetitive strain injury or other strain injury. *Other injuries from external physical causes, such as radiation poisoning, ...
신뢰도 높고 척수손상환자의 신경학적 평가방법인 International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)의 평가에 의하면, ... "Geron comments on FDA hold on spinal cord injury trial.". 2009년 8월 27일.. ... stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury". 》 ...
"Immature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity". Journal of Cellular and Molecular ... a widely expressed activity-dependent neurotic factor that regulates plasticity and is unregulated following hypoxic injury. ... "Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord". ...
Neurotrauma : a comprehensive textbook on traumatic brain injury and spinal cord injury. Wang, Kevin K. W. New York: Oxford ... dendritic injury, neuronal cell body injury, demyelination, synaptic injury and astroglia injury, and microglia responses. ... close head injury [CHI], penetrating ballistic brain injury [PBBI], or blast overpressure wave brain injury [OBI]). (8) The ... Traumatic Brain Injury biomarkersEdit. Investigation of potential copyright issue. Please note this is about the text of this ...
A spinal cord injury or chronic fatigue syndrome might also occasionally cause this disorder.[2] Age may also be a cause of ... Soler JM, Previnaire JG, Plante P, Denys P, Chartier-Kastler E (December 2008). "Midodrine improves orgasm in spinal cord- ... "Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men". J. Sex. Med. 5 (10): 2419-30. doi: ...
Persons with spinal cord injury are at increased risk for urinary tract infection in part because of chronic use of catheter, ... Eves, FJ; Rivera, N (April 2010). "Prevention of urinary tract infections in persons with spinal cord injury in home health ... those with spinal cord injuries, and those who have urinary catheters.[73][74] Pregnancy is an exception and it is recommended ... "Cranberry is not effective for the prevention or treatment of urinary tract infections in individuals with spinal cord injury ...
A few people with ALS have symptoms that are limited to one spinal cord region for at least 12 to 24 months before spreading to ... Head injury[edit]. A 2015 review found that moderate to severe traumatic brain injury is a risk factor for ALS, but whether ... Typical or "classical" ALS involves neurons in the brain (upper motor neurons) and in the spinal cord (lower motor neurons).[27 ... Typical or "classical" ALS involves neurons in the brain (upper motor neurons) and in the spinal cord (lower motor neurons).[27 ...
This makes them at high risk for spinal cord injury, which could be exacerbated by movement of the person and could lead to ... "Cervical spinal fusion". WebMD. Retrieved 2008-03-07. Shantanu S Kulkarni, DO and Robert H Meier III, "Spinal Orthotics", ... Cervical collars are also used therapeutically to help realign the spinal cord and relieve pain, although they are usually not ... It is also used by emergency personnel for those who have had traumatic head or neck injuries, and can be used to treat chronic ...
... or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectly ... the structure or function of all or part of a living organism and that is not the result of any immediate external injury. ... The continuation of the spinal cord within the skull, forming the lowest part of the brainstem and containing control centres ...
In cerebral palsy, spinal cord injury, stroke and possibly multiple sclerosis, oligodendrocytes are thought to be damaged by ... Trauma to the body, e.g. spinal cord injury, can also cause demyelination. The immature oligodendrocytes, which increase in ... Oligodendrocytes are found only in the central nervous system, which comprises the brain and spinal cord. These cells were ... "Oligodendrocyte precursors originate from both the dorsal and the ventral parts of the spinal cord". Neuron. 15 (6): 1299-1310 ...
... for example when the tumor is wrapped around a vulnerable structure such as the spinal cord or a major organ or blood vessel.[ ... In the CNS for example, cranial nerve injury typically presents as a visual acuity loss 1-14 years post treatment.[25] In the ... When Dupuytren's disease is at the nodules and cords stage or fingers are at a minimal deformation stage of less than 10 ... "Gastroduodenal injury after radioembolization of hepatic tumors". The American Journal of Gastroenterology. 102 (6): 1216-20. ...
Spinal cord. *Myelitis: Poliomyelitis. *Demyelinating disease *Transverse myelitis. *Tropical spastic paraparesis. *Epidural ... A population susceptible to the development of sleep disorders is people who have experienced a traumatic brain injury (TBI). ... "Prevalence of sleep disturbances, disorders, and problems following traumatic brain injury: A meta-analysis". Sleep Medicine ...
Learn more about what happens after your spinal cord has been damaged. ... A spinal cord injury - damage to any part of the spinal cord or nerves at the end of the spinal canal (cauda equina) - often ... Common causes of spinal cord injuries. The most common causes of spinal cord injuries in the United States are:. *Motor vehicle ... Falls. A spinal cord injury after age 65 is most often caused by a fall. Overall, falls cause about 31% of spinal cord injuries ...
... information from Spinal Injuries Associaton about the different types of SCI, medical terminology and possible outcomes. ... SIA/LEARN/Understanding spinal cord injury. Understanding spinal cord injury. We know that the amount of information available ... What is spinal cord injury (SCI)?. The spinal cord is an extension of the brain and is made up of a thick bundle of nerves. The ... How will spinal cord injury affect my body?. The higher up you damage the spinal cord, the more movement and sensation will be ...
A spinal cord injury is when the spinal cord gets cut, bruised, stretched, or poked. It can change the way the body moves, ... What Is a Spinal Cord Injury?. A spinal cord injury is when the spinal cord gets cut, bruised, stretched, or poked. It can ... How Are Spinal Cord Injuries Diagnosed?. Right after the injury, doctors will do tests to look at the spinal cord, the spine ( ... How Are Spinal Cord Injuries Treated?. Treatment for a spinal cord injury depends on what muscles, sensations, and functions ...
Infectious Mononucleosis, Influenza, Insomnia, Irritable Bowel Syndrome, Juvenile Arthritis, Kaposis Sarcoma, Laryngitis, Lead Poisoning, Learning Disorders, Leukemia, etc…
Spinal cord injuries disrupt signals between your brain and body. This can cause problems like weakness and paralysis. Read ... Spinal cord injuries can be complete or incomplete. With a complete spinal cord injury, the cord cant send signals below the ... Spinal Cord Injuries (For Parents) (Nemours Foundation) * Spinal Cord Injury (Department of Health and Human Services, Office ... A spinal cord injury disrupts the signals. Spinal cord injuries usually begin with a blow that fractures (breaks) or dislocates ...
Models of spinal cord injury, mechanisms of secondary injury, treatment of the acute phase of spinal cord injury, as well as ... What causes spinal cord injuries?. The causes of spinal cord injury are varied. With industrialization, motor vehicle accidents ... Spinal cord injury research. Spinal cord injury research is an absolute priority of the National Institutes of Health. ... A complete spinal cord injury means that the spinal cord has absolutely no motor or sensory function below the affected area. ...
... as many as half a million people around the world suffer a spinal-cord injury every year, and theres no cure for the resulting ... Scientists at Lineage Cell Therapeutics hope to treat spinal cord injuries with an allogeneic therapy created from ... and spinal-cord injuries.. "Overall," points out Culley, "were indifferent to the technology we use. We just want a cell that ... "We manufacture oligodendrocyte progenitor cells and inject them in the area of the injury," explains CEO Brian Culley. "The ...
Patients with spinal cord injury usually have permanent and often devastating neurologic deficits and disability. ... is an insult to the spinal cord resulting in a change, either temporary or permanent, in its normal motor, sensory, or ... Spinal Cord Injuries) and Spinal Cord Injuries What to Read Next on Medscape. Related Conditions and Diseases. * Spinal Cord ... The epidemiology of spinal cord injury. Stover SL, DeLisa JA, Whiteneck GG, eds. Spinal Cord Injury. Gaithersburg, Md: Aspen; ...
Spinal Cord Injury , 1990 Case Definition ( ...
Acute spinal cord injury is a devastating disease with enormous repercussions, not only for the victims and their families but ... Spinal Cord Injury Mean Arterial Blood Pressure American Spinal Injury Association Acute Spinal Cord Injury Cervical Spinal ... Prusmack C, Rochman AS, Levi AD: The effect of age on survival following traumatic spinal cord injury. J Spinal Cord Med 2006, ... International standards for neurological and functional classification of spinal cord injury. Spinal Cord 1997, 35:266-274. ...
... research spinal cord injuries, and write a proposal to raise funds for and awareness of spinal cord injuries. ... children read a passage about the human spinal cord, ... research spinal cord injuries, and write a proposal to raise ... In this printable worksheet, children read a passage about the human spinal cord, ...
... at the Gladstone Institutes created a special type of neuron from human stem cells that could potentially repair spinal cord ... which contributes to paralysis following spinal cord injuries. "Interneurons can reroute after spinal cord injuries, which ... "Discovery offers new hope to repair spinal cord injuries." Medical News Today. MediLexicon, Intl., 26 Apr. 2017. Web.. 20 Aug. ... The researchers say their next step is to transplant the cells into mice with spinal cord injuries to see if the V2a ...
Helen Smith, consultant clinical psychologist at London Spinal Cord Injury Centre, said: "After a spinal cord injury or illness ... "Suffering a spinal cord injury is a sudden and traumatic event that takes considerable adapting to," said Dr Papathomas. " ... "The Very Alternative Guide to Spinal Cord Injury is one of the first books to deliver this information in an evidence-based way ... The Very Alternative Guide to Spinal Cord Injury has been well received by healthcare professionals. Many are set to use the ...
Spinal Cord Injuries Clinical Research Trial Listings in Musculoskeletal Trauma (Emergency, Injury, Surgery) Family Medicine on ... Spinal Cord Injuries Clinical Trials. A listing of Spinal Cord Injuries medical research trials actively recruiting patient ... Have you had a spinal cord injury over a year ago? Researchers at the University of Kentucky are inviting you to participate in ... Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs Rehabilitation Safety Issues: Safety issues need to be ...
Patients with spinal cord injury usually have permanent and often devastating neurologic deficits and disability. ... is an insult to the spinal cord resulting in a change, either temporary or permanent, in its normal motor, sensory, or ... See also Hypercalcemia and Spinal Cord Injury, Spinal Cord Injury and Aging, Rehabilitation of Persons With Spinal Cord ... Spinal Cord Injuries) and Spinal Cord Injuries What to Read Next on Medscape. Related Conditions and Diseases. * Spinal Cord ...
Spinal Cord Injuries Clinical Research Trial Listings in Musculoskeletal Trauma (Emergency, Injury, Surgery) Family Medicine on ... Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury Spinal. cord. injury. (SCI) affects ~42,000 Veterans. The VA ... Spinal Cord Injuries Clinical Trials. A listing of Spinal Cord Injuries medical research trials actively recruiting patient ... spinal. cord. injury. or multiple sclerosis, middle-age (45-64) is a period of great vulnerability for losses in function and ...
An acute traumatic lesion of the neural elements in the spinal canal, resulting in temporary or permanent sensory deficit, ...
... or lower extremity disabilities or spinal cord injury. ... upper extremity or grasping disabilities or spinal cord injury. ... science work station designed for use by individuals with lower extremity and mobility disabilities or spinal cord injury and ... is a motorized bed designed for use by individuals with obesity and severe physical disabilities or spinal cord injury. ... Trailer is a portable accessible restroom designed for use by individuals with mobility disabilities or spinal cord injury. ...
The mission of the Kentucky Congress on Spinal Cord Injury (KCSCI) is to gather individuals with SCI from around the ...
... can provide a ray of hope for a cure for patients with spinal cord injury (SCI). ... can provide a ray of hope for a cure for patients with spinal cord injury (SCI). ... The Central nervous system consists of the brain, the spinal cord, and the bodys nerve network. This complex system is based ... are unique because of the early intervention with mechanical loading after SCI that is within six months of their injury. Also ...
Purchase Ischemic and Traumatic Brain and Spinal Cord Injuries - 1st Edition. Print Book & E-Book. ISBN 9780128135969, ... 4. Molecular Aspects of Spinal Cord Injury. 5. Potential neuroprotective strategies for spinal cord injury. 6. Molecular ... Ischemic and Traumatic Brain and Spinal Cord Injuries 1st Edition. Mechanisms and Potential Therapies. Write a review ... spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates ...
A new mouse study finds that counteracting changes in gut bacteria that arise from spinal cord injury with probiotics could ... better recovery from spinal cord injury. So-called good bacteria, found in probiotics, could help aid recovery from spinal cord ... "could explain how post-injury disruption of the gut microbiome contributes to the pathology of spinal cord injuries and how ... "Probiotics may help spinal cord injury recovery." Medical News Today. MediLexicon, Intl., 17 Oct. 2016. Web.. 23 Aug. 2019. , ...
The goal is to make better recommendations to people with spinal cord injury, but the research will also translate into greater ... Researchers at the University of Michigan Health System are looking at how people with spinal cord injury burn calories and how ... About spinal cord injury. *About 250,000 Americans are living with a spinal cord injury - roughly two times the capacity of the ... director of Spinal Cord Injury Medicine at UMHS and director of the Spinal Cord Injury Research Center at the VA Ann Arbor ...
As many as 500.000 people suffer spinal cord injury each year, with survival rates worse in low-income and middle-income ... 500,000 suffer from spinal cord injuries. Geneva, December 2, 2013. As many as 500.000 people suffer spinal cord injury each ... care and lived experience of people with spinal cord injury. The WHO experts said up to 90 per cent of spinal cord injury cases ... The International perspectives on spinal cord injuries report developed in association with the International Spinal Cord ...
Depending where the injury is and how severe it is, it can lead to partial or complete loss of feeling and control in just the ... Traumatic spinal cord injury (SCI) means there is damage to the nerves that run through the backbone (spine). ... Condition: Traumatic spinal cord injury (SCI) means there is damage to the nerves that run through the backbone (spine). ... Recovery depends on how severe the injury is. Most improvement is seen in the first 6 months after the injury. ...
Traumatic spinal cord injuries are increasing with the population, and incidence is higher in older individuals, according to a ... "We find that spinal cord injury as a result of falls is a major public health issue in the older patients, and we need to find ... Traumatic spinal cord injuries are increasing with the population, and incidence is higher in older individuals, according to a ... People with traumatic spinal cord injury are often disabled for life, and require lifelong rehabilitation. That impacts their ...
Spinal cord injury and pregnancy. Spine 1991;16:596-8. Verduyn WH. Spinal cord injured women, pregnancy and delivery. ... Recent demographic and injury trends in people served by the Model Spinal Cord Injury Care Systems. Arch Phys Med Rehabil 1999; ... Approximately 11,000 new spinal cord injuries (SCIs) are reported per year in the United States. More than 50% occur in persons ... Obstetric Management of Patients with Spinal Cord Injuries. ABSTRACT: Effective rehabilitation and modern reproductive ...
... work that they hope will one day help people with similar injuries. ... Dogs with spinal cord injuries may soon benefit from an experimental drug being tested by researchers at UCSF and Texas A&M ... Statistics on Human Spinal Cord Injuries. *About 265,000 Americans are living with spinal cord injuries. ... Instead, it aims to mitigate damage secondary to the spinal cord injury. Most spinal cord injuries trigger a cascade of ...
Severe sepsis or pneumonia frequently follows treatment with high-dose methylprednisolone that is frequently used in spinal ... Drugs & Diseases , Emergency Medicine , Spinal Cord Injuries Q&A What causes sepsis in spinal cord injury (SCI)?. Updated: Nov ... The epidemiology of spinal cord injury. Stover SL, DeLisa JA, Whiteneck GG, eds. Spinal Cord Injury. Gaithersburg, Md: Aspen; ... National Spinal Cord Injury Statistical Center (NSCIS). Spinal cord injury facts and figures at a glance. February 2011. [Full ...
The Healthsouth Spinal Cord Injury Handbook for Patients and Their Families. Birmingham, AL: Healthsouth Corporation, 1998. ... Journey to Well: Learning to Live After Spinal Cord Injury. Newcastle, CA: Altarfire Publishing, 1998. ... Spinal Cord and Head Injuries. NOAH: New York Online Access to Health. [Online] ( ... The National Spinal Cord Injury Association. 8300 Colesville Road, Silver Springs, MD 20910. (301) 588-6959. http://www.erols. ...
  • A Washington University research study seeks participants with cervical spinal cord injury. (
  • SCIWORA is most commonly seen in children with a predilection for the cervical spinal cord due to the increased mobility of the cervical spine, the inherent ligamentous laxity, and the large head-to-body ratio during childhood. (
  • Current treatment strategies of acute cervical spinal cord injuries remain limited. (
  • Specific Aim: Measure the efficacy of nerve transfer surgery in the treatment of patients with complete cervical spinal cord injuries with no hand function. (
  • To understand the effects of early surgical decompression following spinal cord injury , Dr. Fehlings and colleagues conducted a prospective, nonrandomized, multicenter study involving 313 patients with acute cervical spinal cord injury, 182 of whom underwent early surgery at less than 24 hours after injury (mean, 14.2 hours) and 131 of whom underwent late surgery (mean, 48.3 hours). (
  • American Spinal Injury Association. (
  • SATURN is a prospective cohort study of patients with moderately-severe to severe spinal cord injury, defined as American Spinal Injury Association Impairment Scale A and B, who are treated with open-label NeuroAiD for 6 months in addition to standard care and followed for 24 months. (
  • In accordance with its internal focus on scientific rigor, Asubio recently discussed its endpoint development activities at a peer-attended symposium at the American Spinal Injury Association ( ASIA ) annual meeting. (
  • She has presented research at national conferences of the American Spinal Injury Association, the American Association of Spinal Cord Injury Psychologists and Social Workers (now the Academy of SCI Professionals), the American Public Health Association, and the American Psychological Association. (
  • Multivariate analysis indicated that the odds of ≥2 grade improvement in American Spinal Injury Association (ASIA) Impairment Scale was 2.8 times higher among patients who received early surgery as compared to those who underwent late surgery (OR = 2.83). (
  • American Spinal Injury Association (ASIA) method for classifying spinal cord injury (SCI) by neurologic level. (
  • The International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), published by the American Spinal Injury Association (ASIA), is widely used to document sensory and motor impairments following SCI. (
  • Numbness or paralysis may occur immediately or come on gradually as bleeding or swelling occurs in or around the spinal cord. (
  • There are approximately 10,000 new injuries in the United States each year with more than 200,000 people suffering from either paralysis of the arms or legs or both secondary to spinal cord injury. (
  • Improvement in the quality of care over the last few decades has dramatically improved the outlook and survival for patients with such injuries - but as yet there are no cures to treat all aspects of the injury including paralysis. (
  • ANN ARBOR--An injection of nanoparticles can prevent the body's immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis. (
  • That spectrum includes everything from paralysis to a loss of sensation for many of the 12,000 new spinal injury patients each year in the United States. (
  • Damage to V2a interneurons can sever connections between the brain and the limbs, which contributes to paralysis following spinal cord injuries. (
  • About 120 dogs a year that develop sudden onset hind limb paralysis after such injuries are brought to the Small Animal Hospital of Texas A&M University, where they receive surgical and medical treatment similar to that for human spinal cord injury. (
  • The injured dogs offer a great opportunity to take the next step on this treatment because their injuries more closely mimic spontaneous human spinal cord injury and, as is the case with humans, no existing treatment has substantially reduced paralysis. (
  • One of the most common features of spinal cord injury is paralysis. (
  • The spinal cord is the control center for the nerves, which run like spaghetti all the way out to the tips of the fingers and the tips of the toes," noted Mackinnon, the director of the School of Medicine's Center for Nerve Injury and Paralysis, in a statement. (
  • We at Spinal Research want to see the day when spinal cord injury does not mean a lifetime of paralysis. (
  • A spinal cord injury closer to the neck will typically cause paralysis throughout a larger part of the body than one in the lower back area. (
  • In rats whose spinal cords were completely cut - the worst kind of paralysis injury - scientists from Case Western Reserve University and the Cleveland Clinic were able to prod nerve fibers to gradually grow across gaps the width of a pencil and reconnect. (
  • In the most serious cases, a spinal cord injury can mean permanent paralysis. (
  • Note: Spinal cord injuries, paralysis and other catastrophic injuries are areas of personal injury practice. (
  • If you have been injured and paralyzed due to the negligence of another person or entity, it is vital to hire a spine injury attorney who is experienced in matters of paralysis. (
  • Typically, the athlete has some degree of paralysis below the point of injury. (
  • These results open the exciting possibilities not only to treat hypotension in people with chronic spinal-cord injuries but also in a very early phase after an injury which could increase the overall recovery, including treating the paralysis," said EPFL neuroscientist Grégoire Courtine. (
  • Transcranial magnetic stimulation has been under study as a treatment for depression and for some after-effects of stroke , while other forms of electrical stimulation have been studied in paralysis after spinal cord injury. (
  • Who's whoPorter is the first of six Baltimore police officers charged in Gray's death to stand trial.Dr. Matthew Ammerman testified that Gray suffered a "catastrophic and complete" spinal cord injury with paralysis and death occurring in milliseconds. (
  • In the meantime, treatments and rehabilitation allow many people with spinal cord injuries to lead productive, independent lives. (
  • Many of the consequences associated with spinal cord injury do not result from the condition itself, but from inadequate medical care and rehabilitation services, and from barriers in the physical, social and policy environments that exclude people with spinal cord injury from participation in their communities, it added. (
  • The study, which analyzed data from 63,109 patients with acute traumatic spinal cord injury from 1993 to 2012, will help target specific populations for preventive measures, said lead author Nitin B. Jain, M.D., M.S.P.H, associate professor of Physical Medicine and Rehabilitation. (
  • People with traumatic spinal cord injury are often disabled for life, and require lifelong rehabilitation. (
  • The study of the epidemiology of a disabling condition like spinal cord injury will help us define an action plan for future rehabilitation services. (
  • ABSTRACT: Effective rehabilitation and modern reproductive technology may increase the number of women considering pregnancy who have spinal cord injuries (SCIs). (
  • After a spinal cord injury, you'll need spinal cord injury rehabilitation to optimize recovery and perhaps adapt to a new way of life. (
  • Mayo Clinic's spinal cord injury rehabilitation team treats people with all causes of traumatic or nontrauma spinal cord injuries, including spinal cord tumors , spinal cord or vertebral infections, transverse myelitis , Guillain-Barre syndrome , multiple sclerosis , myelopathies, spinal cord infarctions and aneurysms . (
  • She is Principal Investigator for the current SCI Model Systems module project, "Utilization of Complementary and Integrative Healthcare to Treat Pain in Persons with Spinal Cord Injury" and a Craig H Neilsen Foundation-funded project, "A Bridge from Rehabilitation to Real-World: Reinventing Yourself after SCI. (
  • Craig Hospital in Denver, Colorado is a world-renowned rehabilitation hospital that specializes in the neuro-rehabilitation and research of patients with spinal cord injury (SCI) and traumatic brain injury (TBI). (
  • Ana Lucas-Osma, a research associate at the University of Alberta's Faculty of Rehabilitation Medicine, suffered a T7 spinal cord injury in Spain when she was 18. (
  • You also may expect to undergo intense rehabilitation treatment for your spinal cord injury. (
  • In the present book, twelve typical literatures about spinal cord injury published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on spinal cord stimulation, incomplete spinal cord injury, central cord syndrome, prehospital treatment, spinal cord injury without radiographic abnormality and rehabilitation, etc. (
  • 28-73422 ) to learn more about our spinal cord injury rehabilitation program or to refer a patient. (
  • Information is available to you throughout the UPMC Rehabilitation Institute's spinal cord injury webpages, as well as in documents from both inpatient and outpatient health care professionals. (
  • These injuries can range from the minor to the severe, and each requires a different level of medical treatment and rehabilitation. (
  • Regardless of whether your spinal cord injury resulted from traumatic or non-traumatic means, at TIRR Memorial Hermann, the rehabilitation process remains relatively the same. (
  • Brain and Spinal Cord Injury Rehabilitation puts most families in crushing debt. (
  • Comprehensive follow-up study of spinal cord dysfunction and its resultant disabilities final report to the National Advisory Council on Vocational Rehabilitation and the Vocationa. (
  • Virginia model regional center system for spinal cord injury rehabilitation final report. (
  • The Institute for Rehabilitation and Research Texas Regional Spinal Cord Injury Center. (
  • Virginia model regional center system for spinal cord injury rehabilitation executive summary. (
  • Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. (
  • The Center provides comprehensive surgical, nonsurgical, and rehabilitation care to individuals with spinal trauma, as well as spinal cord injury. (
  • In addition, rehabilitation specialists provide all therapies designed to enhance maximum recovery from spinal cord injury and return to the community. (
  • Dr. Jerry Mysiw, a physician in physical medicine at Ohio State's Dodd Hall rehabilitation facility and medical director for the study, says spinal cord injuries are devastating and affect every aspect of a patient's life. (
  • LAS CRUCES - Rehabilitation Hospital of Southern New Mexico has earned The Joint Commission's Gold Seal of Approval for Spinal Cord Injury Certification. (
  • This program provides a coordinated, outcome-driven, integrated rehabilitation program addressing the complicated needs of adults with spinal cord injury. (
  • With a complete spinal cord injury, the cord can't send signals below the level of the injury. (
  • A complete spinal cord injury means that the spinal cord has absolutely no motor or sensory function below the affected area. (
  • Definition of complete spinal cord injury. (
  • Patients will be selected based on their baseline cervical motor level of sensori motor complete spinal cord injury ( ASIA Impairment Scale A, with a C4 to C7 level of cord injury) and will be stratified according to the baseline cervical motor level. (
  • Rob Summers has a complete spinal injury that doctors said would prevent him from walking. (
  • We've shown for the very first time that we can promote long-distance regeneration in the adult spinal cord, across a complete spinal cord lesion. (
  • In a "complete" spinal injury, all functions below the injured area are lost, whether or not the spinal cord is severed. (
  • Anyone who experiences significant trauma to his or her head or neck needs immediate medical evaluation for the possibility of a spinal injury. (
  • Damage to the spinal cord can be caused by a trauma like an accident, or as a result of infection or disease. (
  • With industrialization, motor vehicle accidents (MVA) have become the leading cause of spinal trauma. (
  • Spinal immobilization in patients with penetrating trauma is not recommended. (
  • The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells--call it an "EpiPen" for trauma to the central nervous system, which includes the brain and spinal cord. (
  • Trauma centers must first sign on to participate in the study, and then attending trauma physicians and nurses will identify eligible patients when they arrive at a facility with a spinal cord injury. (
  • They say they found that trauma-induced spinal cord compression on MRIs predict a poorer neurological recovery. (
  • Spinal trauma. (
  • trauma&alt=sh. (
  • The primary injury refers to the initial physical trauma to the spine. (
  • Trauma can cause impact of bone, disc, and/or ligament against the tissues by narrowing the spinal canal or even dramatically changing its alignment. (
  • While complete transection, or severing of the cord, is rare, the spinal cord can be badly damaged with even the slightest trauma delivered directly to it. (
  • Damage to the spinal cord can be seen on an MRI immediately following trauma. (
  • The secondary injury is the cascade of events in the body after the initial trauma-the body's attempt to deal with the injury. (
  • There is a surge of chemicals released by the body in response to trauma that causes inflammation, decreased spinal cord blood flow, and cell death. (
  • The answer would probably be "Yes," since MRI is never the first-line imaging modality in the setting of acute spinal trauma. (
  • A spinal cord injury (SCI) can happen with trauma or disease to the spinal column. (
  • Each year, as many as 11,000 spinal cord injuries occur in the U.S. Most of these injuries are caused by trauma to the vertebral column. (
  • This study provides exciting new insights into the complications of spinal cord trauma and gives us the possibility of identifying both imaging biomarkers and therapeutic targets. (
  • Members of the Department of Neurosurgery have developed extensive expertise and are nationally recognized in the management of spinal trauma. (
  • Our Program is structured to address the complex physical and psychological needs of a person with spinal cord injury as a result of trauma or tumor. (
  • In the majority of cases the damage results from physical trauma such as car accidents, gunshot wounds, falls, or sports injuries, but it can also result from nontraumatic causes such as infection, insufficient blood flow, and tumors. (
  • The lowest normal part of your spinal cord is referred to as the neurological level of your injury. (
  • Your health care team will perform a series of tests to determine the neurological level and completeness of your injury. (
  • The clinician uses the patient's neurological exam, age, magnetic resonance imaging (MRI) appearance of the spinal cord, and other clinical data to guide the patient and his family on the expected outcome for a specific injury. (
  • Ditunno JF Jr, Young W, Donovan WH, Creasey G. The international standards booklet for neurological and functional classification of spinal cord injury. (
  • Safety Issues: Safety issues need to be watched are: occurrence of known and unknown undesirable incidences, moving up injury levels, loss of previously preserved neurological functions, vital physical signs, and worsening of EKG and lab results. (
  • The 3G Arrow Rear Wheel Drive Power Wheelchair with TrueTrack is a powered wheelchair designed for use by individuals with mobility, neurological, or lower extremity disabilities or spinal cord injury. (
  • The 3rd Hand Small Electronics Mount is an extension arm for wheelchair accessories designed for use by individuals with mobility or neurological disabilities or spinal cord injury. (
  • PARAMUS, N.J. , April 23, 2012 /PRNewswire/ -- Today, Asubio announced the initiation of a landmark Phase 2 clinical trial of SUN13837, an investigational medication being developed to improve neurological function in patients with newly diagnosed acute spinal cord injury. (
  • This randomized, placebo-controlled study will determine whether subjects receiving SUN13837 are more likely to improve by two or more motor levels from baseline on either their right or left side as determined using the International Standards for Neurological Classification of Spinal Cord Injury Scale. (
  • They examined whether there is an association between the degree of spinal cord injury compression in the period just after traumatic injury and clinical neurological outcome. (
  • In 1990, a multi-center trial of methylprednisolone showed that the steroid improved neurological function in a subset of patients who were given the drug within the first eight hours of injury. (
  • Similar approaches could be taken for patients with traumatic brain injury, stroke and neurological disorders which also may alter the clock, the researchers note. (
  • At study, entry subjects were one or more years following injury, had completed a detailed health questionnaire, and underwent pulmonary function testing and a neurological exam. (
  • Preclinical animal studies consistently have shown that surgical decompression following spinal cord injury attenuates secondary injuries and improves neurological outcomes, Dr. Fehlings said. (
  • If it isn't recognized, a more severe injury may occur. (
  • Spinal fractures occur when an injury is sustained to the spine resulting in a break or disruption of the spinal vertebrae or the attached ligaments. (
  • How do spinal cord injuries usually occur? (
  • Injury can occur at any level of the spinal cord and can be complete injury, with a total loss of sensation and muscle function, or incomplete, meaning some nervous signals are able to travel past the injured area of the cord. (
  • An SCI may occur if your spinal column presses down on or pinches your spinal cord. (
  • Unlike diffuse brain injuries, which occur throughout the brain, focal brain injuries are confined to one area of the brain. (
  • The trial design described below took into account the concomitant injuries that co-occur with acute complete thoracic SCI, the need for a nerve harvest and second spinal surgery, and the need for reliable baseline data. (
  • This paper demonstrates for the first time that these changes already occur within 40 days of acute spinal cord injury. (
  • Ultimately, the goal is to promote growth and sustain it long enough for recovery of movement to occur in spinal cord injury patients," he concludes. (
  • Just over half of injuries affect the cervical spine, while 15% occur in each of the thoracic spine, border between the thoracic and lumbar spine, and lumbar spine alone. (
  • But a new study finds a surprising benefit of maintaining a healthy gut: better recovery from spinal cord injury. (
  • So-called good bacteria, found in probiotics, could help aid recovery from spinal cord injury. (
  • Damage to your spinal cord in your back will result in paraplegia. (
  • Depending where the injury is and how severe it is, it can lead to partial or complete loss of feeling and control in just the legs (paraplegia) or both the arms and legs (tetraplegia). (
  • Spinal Cord Injuries Australia (SCIA) is a non-government organisation which provides advocacy and services to people with spinal cord injury (paraplegia, quadriplegia) and similar conditions. (
  • Paraplegia occurs when the legs are affected by the spinal cord damage (in thoracic, lumbar, or sacral injuries), and tetraplegia occurs when all four limbs are affected (cervical damage). (
  • Long-term treatments include helping people live with changes caused by the injury. (
  • Other treatments are being studied to see how they can help people with a spinal cord injury. (
  • What Are the Treatments for Spinal Cord Injury (SCI)? (
  • Guidelines related to spinal cord injuries treatments are focused on avoidance of secondary injury from compressive lesions and hemodynamic instability. (
  • Much of the controversy in the treatment of these injuries stems from insufficient knowledge about the pathophysiology of the disease as well as the timing of certain treatments such as surgery. (
  • No treatments available today can regenerate nerve cells in the adult brain and spinal cord, where neuron regrowth is extremely limited. (
  • One of the initial treatments is to immobilize the spine to prevent further injury. (
  • We are really hopeful that we can develop treatments that can have an impact for people living with spinal-cord injuries. (
  • Treatments targeting the injured spinal cord have entered clinical trials. (
  • Some of these treatments could be planned concurrently with neurosurgical approaches that are themselves beneficial to decrease secondary damage (e.g., decompression/reconstructive spinal surgery). (
  • Clearly this would have no utility in clinical situations, where treatments cannot be made in anticipation of spinal cord injury," says Basbaum. (
  • Research into potential treatments includes stem cell implantation, engineered materials for tissue support, epidural spinal stimulation, and wearable robotic exoskeletons. (
  • Right after the injury, doctors will do tests to look at the spinal cord, the spine (the bones that make up the backbone and protect the spinal cord), and the surrounding bones and tissues. (
  • Spinal cord injuries usually begin with a blow that fractures (breaks) or dislocates your vertebrae, the bone disks that make up your spine. (
  • Some injuries affect only the spinal column without disturbing the nerve elements - while other, more severe injuries to the spine can result in temporary or permanent damage to the spinal cord and/or exiting nerve roots. (
  • Treatment for patients with spinal cord injury often involves stabilizing the injured spine. (
  • As part of the surgical treatment the spine may be re-aligned or bone may be removed from the spinal canal to decompress the spinal cord. (
  • Cervical spine injury is highly dependent on the mechanism of injury following blunt and penetrating assault. (
  • AANS Guidelines for the Management of Acute Cervical Spine and Spinal Cord Injuries. (
  • Timely, appropriate pre-hospital management: quick recognition of suspected spinal cord injury, rapid evaluation and initiation of injury management, including immobilization of the spine. (
  • Traumatic spinal cord injury (SCI) means there is damage to the nerves that run through the backbone (spine). (
  • The nerves are able to communicate with the brain because they´re attached to the part of the spine that´s above the injury. (
  • It's very important to caution that this applies only to those with spinal injuries far enough down on the spine that there are remnants of nerves that are still functional above the injury that can be tapped into," stated Dr. J. Marc Simard , a professor of neurosurgery, pathology and physiology at the University of Maryland School of Medicine in Baltimore in a article by U.S. News . (
  • As long as the nerves are connected to the support of the spine, then the nerves and related muscles stay healthy even long after injury. (
  • Spinal Cord Injury without Radiographic Abnormality" (SCIWORA) is a term that denotes objective clinical signs of posttraumatic spinal cord injury without evidence of fracture or malalignment on plain radiographs and computed tomography (CT) of the spine. (
  • The acronym SCIWORA (Spinal Cord Injury without Radiographic Abnormality) was first defined in 1982 by Pang and Wilberger Jr. in a series of 24 children who suffered traumatic myelopathy with no radiographic evidence of fractures, dislocations, or malalignment of the spine [ 1 ]. (
  • Pang and Pollack described SCIWORA as a syndrome in which there are clinical signs of traumatic spinal cord injury (SCI) without overt traumatic vertebral column disruption as displayed by spine X-rays, computed tomographic (CT) scans, myelograms, and dynamic flexion/extension X-rays [ 2 ]. (
  • The spinal cord is a bundle of nerves and other tissue that the vertebrae of the spine contains and protects. (
  • A spinal Cord Injury is an amazingly genuine kind of injury when spine that breaks or separates vertebrae. (
  • These vertebrae function to stabilize the spine and protect the spinal cord. (
  • For Professionals › News And Research › Spine Summit 2016 › Early Surgical Decompression Improves Outcomes From Spinal C. (
  • Early decompression should be considered as a treatment option for adults with traumatic spinal cord injuries, particularly in people with severe injury, said Michael G. Fehlings, MD, PhD , at Spine Summit 2016 held March 16-19 in Orlando, Florida. (
  • 1 "The concept that I want to emphasize is that 'time is spine,' and that timing does matter," said Dr. Fehlings, who is Professor of Neurosurgery and Co-Director of the Spine Program at the University of Toronto in Ontario and Chair of AOSpine North America and the AOSpine International Spinal Cord Injury Knowledge Forum. (
  • The evidence supporting early surgery is mirrored by survey result from nearly 1,000 spine surgeons, the majority of whom (≥80%) preferred to decompress the spinal cord within 24 hours of injury, Dr. Fehlings explained. (
  • The severity of the loss of sensation and movement depends on the location of the injury on the spine. (
  • Following spine and wrist surgeries there, she traveled to Chicago for several months of spinal cord therapy. (
  • But now, U-M researchers have designed nanoparticles that intercept immune cells on their way to the spinal cord, redirecting them away from the injury. (
  • When the researchers transplanted the cells into mouse spinal cords, the interneurons sprouted and integrated with existing cells. (
  • In addition to the more overt effects of traumatic spinal cord injuries, the researchers say they have secondary effects, including loss of bowel control, which can cause disruption to the gut microbiome. (
  • With all of their background knowledge on the effects of the gut microbiome, the researchers hypothesized that changes in the gut microbiome could affect spinal cord injury recovery. (
  • The researchers say these immune cells - called regulatory T cells - could prevent extra damage to the spinal cord after injury. (
  • Researchers at the University of Michigan Health System are looking at how people with spinal cord injury burn calories and how that is affected by their muscle mass and body weight. (
  • For the study researchers evaluated the records of 22 patients who were admitted to the hospital with spinal cord injury and who were assessed with both MRI and computed tomography at admission and at a follow-up examination about 10 months later. (
  • In conclusion researchers say MRI should be done whenever feasible in all patients with an acute spinal cord injury to evaluate the extent of spinal cord compression. (
  • Dogs with spinal cord injuries may soon benefit from an experimental drug being tested by researchers at the University of California, San Francisco (UCSF) and Texas A&M College of Veterinary Medicine & Biomedical Sciences - work that they hope will one day help people with similar injuries. (
  • NEW YORK (Reuters Health) - A sensorimotor neural interface successfully restored touch sensation in a patient with quadriplegia resulting from spinal cord injury (SCI), researchers report. (
  • New software sifts through the information gathered in long forgotten studies and finds new avenues for researchers to pursue-like a new advance in treating spinal injuries. (
  • Spinal cord injury researchers are facing a crisis of their own. (
  • Before Ferguson had thought to use it for probing spinal cord injuries, Carlsson and others researchers had successfully employed TDA to find a unique mutation in breast cancers hiding in data sets that had been publicly available for more than a decade. (
  • We hope this book can demonstrate advances in spinal cord injury as well as give references to the researchers, students and other related people. (
  • The researchers studied rats in the immediate aftermath of a moderate injury to the thoracic, or middle, spinal cord. (
  • This content was published on Oct 31, 2018 Oct 31, 2018 Researchers in Switzerland have helped three paraplegic patients walk through electrical stimulation of the spinal cord using a wireless implant. (
  • Precisely timed nerve stimulation in patients with spinal cord injuries improved their ability to use their hands, at least temporarily, researchers reported. (
  • The corticospinal tract conducts nerve signals from the brain's motor cortex to the spinal cord and plays a major role in voluntary movement, the researchers noted. (
  • The researchers then implanted into each rat a small pump that delivered a steady stream of sialidase directly to the injury over the course of two weeks, hoping that bathing the injured nerves in the enzyme would help their recovery and promote regrowth. (
  • The study, reported in the November 15 issue of the Proceedings of the National Academy of Sciences, builds on earlier findings in which the researchers were able to induce cell growth by manipulating the nervous system before a spinal cord injury, but not after. (
  • Previously, the researchers had shown in animal studies that an injury made to the peripheral branch prior to a spinal cord injury provided the essential communication signal that enabled the CNS branch to grow. (
  • Another challenge the researchers faced was stimulating CNS cells to grow beyond the injury site and into healthy tissue, which is essential to help regain function. (
  • In the new study, researchers evaluated the effect of two peripheral nerve lesions (injuries) in animals with spinal cord injury. (
  • The researchers found that the two "priming lesions" not only promoted significant spinal cord regeneration within the area of the spinal cord injury, but more important, the regenerating axons grew back into normal areas of the spinal cord, where the hope is that functional connections can be reestablished. (
  • The time between injury and treatment can be critical in determining the extent and severity of complications and the possible extent of expected recovery. (
  • It is our opinion that early recognition of spinal cord injury and careful management in an intensive care setting can prevent many of the medical complications that are the major source of morbidity and mortality in these patients. (
  • People with spinal cord injury also risk developing secondary conditions that can be debilitating and even life-threatening, such as deep vein thrombosis, urinary tract infections, pressure ulcers and respiratory complications. (
  • Furlan JC, Fehlings MG. Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management. (
  • People who survive a spinal cord injury will most likely have medical complications such as chronic pain and bladder and bowel dysfunction, along with an increased susceptibility to respiratory and heart problems. (
  • Respiratory complications, primarily as a result of pneumonia , are a leading cause of death in people with spinal cord injury. (
  • A spinal cord injury (SCI) survivor will experience a lifetime of ongoing treatment of different types and medical complications of varying degrees according to the severity of their injury. (
  • And with good reason - skin breakdown remains one of the leading complications spinal cord injury (SCI) survivors have. (
  • National Spinal Cord Injury Statistical Center (NSCIS). (
  • The spinal cord is an extension of the brain and is made up of a thick bundle of nerves. (
  • When the spinal cord is damaged, the communication between our brain and the rest of our body is disrupted, resulting in a loss of movement and sensation from below the level of injury. (
  • The spinal cord is a cable that goes from the brain down to the lower back. (
  • V2a interneurons relay signals from the brain to the spinal cord, where they ultimately connect with motor neurons that project out to the arms and legs. (
  • Most of these trials involve stem cell-derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells. (
  • The Central nervous system consists of the brain, the spinal cord, and the body's nerve network. (
  • Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. (
  • Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. (
  • A typology of alcohol use patterns among persons with recent traumatic brain injury or spinal cord injury: implications for treatment matching. (
  • The spinal cord is one long, thin bundle of nerves that spans the length of the back carrying nervous impulses to and from various parts of the body to the brain. (
  • The participant has a very severe spinal cord injury that could have blocked this signal traveling from the hand to the brain. (
  • Dr. Andrew Jackson, professor of neural interfaces at Newcastle University, in Newcastle-upon-Tyne, U.K., told Reuters Health by email, "The study rests on a surprising finding: touch stimuli that are imperceptible to a spinal cord-injured participant can nevertheless be 'decoded' from brain activity in the motor cortex. (
  • Previous brain imaging studies have suggested such signals can reach the brain even after injury, but this is the first study to reveal them in the activity of individual brain cells. (
  • What was thought to have been a boondoggle turns out to have great value," says Adam Ferguson , a principal investigator at UCSF's Brain and Spinal Injury Center and one of the paper's authors. (
  • They reasoned that such an approach might allow people with spinal-cord injuries to stand and walk, using electrical stimulation to replace the signals that once came from the brain. (
  • Prevailing wisdom has long held that spinal-cord injuries represent severed connections between the brain and the extremities. (
  • Patients who have injuries at the C6 and C7 vertebra generally have no hand function, but can move the shoulder, elbow, and some parts of the wrist as the nerves connect to the brain and are found above the injury point. (
  • The problem is that these nerves no longer 'talk' to the brain because the spinal cord injury blocks the signals. (
  • Many of our reflex movements are controlled by the spinal cord but regulated by the brain. (
  • When the spinal cord is damaged, information from the brain can no longer regulate reflex activity. (
  • The spinal cord is responsible for sending messages from the brain to all parts of the body. (
  • Below C6 have lost communication with the spinal cord and brain. (
  • Silver's and Lee's research is 'exceptionally rigorous,' and the pair's findings have 'potential clinical importance,' said neuroscientist Phillip Popovich, director of Ohio State University's Center for Brain and Spinal Cord Repair . (
  • It could also have implications for stroke and traumatic brain injury patients, the authors say. (
  • Invoking the names of Jack Jablonski and Gabe Rodreick, young Minnesotans who suffered spinal cord injuries, two state legislators are proposing an $8 million grant program for spinal cord and brain injury research. (
  • The spinal cord is a bundle of nerves that carries messages between the brain and the rest of the body. (
  • In most cases, the brain tissue is damaged at the site where the injury occurred. (
  • There are several different types of focal brain injuries. (
  • A closed injury occurs when pieces of the skull press into the brain, while an open injury occurs when something pierces the skull and enters brain tissue. (
  • Signs and symptoms of focal brain injury vary widely, depending upon which area of the brain is damaged. (
  • For example, if the area of the brain responsible for speech is damaged, than speech will be affected to some degree depending upon the severity of the injury. (
  • Focal brain injuries can be categorized as mild, moderate , or severe. (
  • Yes, a car crash can cause a traumatic brain injury (TBI) in many ways. (
  • A traumatic brain injury (TBI) occurs when there is a "bump, blow, or jolt to the head" that causes issues with the functions of the. (
  • Can a Fall Cause Traumatic Brain Injury? (
  • The rate and extent of damage to the spinal cord and brain following spinal cord injury have long been a mystery. (
  • A spinal cord injury changes the functional state and structure of the spinal cord and the brain. (
  • The assumption was that it took years for patients with a spinal cord injury to also display anatomical changes in the spinal cord and brain above the injury site. (
  • Research suggests that we can retrain spinal cords to recognize movements and not work directly through the brain. (
  • Sexual function in humans is controlled by parts of the central nervous system (CNS), particularly the brain and spinal cord. (
  • Key to the research is an important difference in the properties of the nerve fibers of the central nervous system (CNS), which consists of the brain and spinal cord, and those of the peripheral nervous system (PNS), which is the network of nerve fibers that extends throughout the body. (
  • Axons are the long, fragile, fibers that conduct impulses between nerve cells in the brain, spinal cord and limbs. (
  • Instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. (
  • Your spinal cord is protected by vertebrae that make up your spinal column. (
  • Injury to the vertebrae does not always mean the spinal cord has been damaged. (
  • Likewise, damage to the spinal cord itself can happen without fractures or dislocations of the vertebrae. (
  • For example, an injury at C2 or C3 (the second and third vertebrae in the spinal column), affects the respiratory muscles and the ability to breathe. (
  • A lower injury, in the lumbar vertebrae, may affect nerve and muscle control to the bladder, bowel, and legs. (
  • At each level of the spinal column, spinal nerves branch off from either side of the spinal cord and exit between a pair of vertebrae, to innervate a specific part of the body. (
  • A careful neurologic assessment, including motor function, sensory evaluation, deep tendon reflexes, and perineal evaluation, is critical and required to establish the presence or absence of spinal cord injury and to classify the lesion according to a specific cord syndrome. (
  • In the absence of spinal shock, motor weakness with intact reflexes indicates spinal cord injury, whereas motor weakness with absent reflexes indicates a nerve root lesion. (
  • Finally, rehabilitative approaches based on the presence of functional networks (i.e., central pattern generator) below the lesion combined with the above neurobiological approaches may produce significant functional recovery of some sensorimotor functions, such as locomotion, by ensuring an optimal function of endogenous spinal networks and establishing new dynamic interactions with supralesional structures. (
  • The repair of the spinal cord requires a good knowledge of the mechanisms of the lesion itself, of axonal growth, of anatomical and functional organization of the spinal cord, as well as of other structures of the CNS. (
  • Figure 1 schematically represents (left) a spinal lesion that usually results in a cavitation with various degrees of local damage. (
  • A PNS injury at the time of spinal cord damage will only promote growth of nerve fibers into the spinal cord lesion, but not into the tissue beyond it. (
  • One lesion was made at the time of the cord injury and a second was made a week later. (
  • There is a window of opportunity just after the injury when the potential for growth through and beyond the lesion is greatest. (
  • Instead, it aims to mitigate damage secondary to the spinal cord injury. (
  • Spinal cord injury is traditionally discussed in two phases: primary and secondary injury. (
  • In the seconds, hours, days, and weeks afterward, several factors play a role in the severity of the secondary injury. (
  • Treatment of spinal cord injury aims to reduce the effects of primary and secondary injury. (
  • Secondary injuries include vasogenic edema, neurogenic shock, loss of autoregulation, and cytotoxic edema, among a host of other negative effects. (
  • The damage can also be divided into primary and secondary injury: the cell death that occurs immediately in the original injury, and biochemical cascades that are initiated by the original insult and cause further tissue damage. (
  • Co-author Joe Robinson added his own experiences of living with a spinal cord injury and complemented the publication with inventive illustrations and photographs. (
  • After living with a spinal cord injury for 10 years, Mark Pascoe knows he needs to work hard to keep his weight down. (
  • About 250,000 Americans are living with a spinal cord injury - roughly two times the capacity of the U-M football stadium. (
  • In the U.S., there are over 250,000 people living with a spinal cord injury. (
  • The scientists studied 13 patients with acute spinal cord injuries every three months for a year using novel MRI (magnetic resonance imaging) protocols. (
  • If you have injured the spinal cord in your back, you will have injured either thoracic nerves (1-12) or lumber nerves (1-5). (
  • When injuries are at the C5 level and below, diaphragm function is preserved, but breathing tends to be rapid and shallow and people have trouble coughing and clearing secretions from their lungs because of weak thoracic muscles. (
  • The most common sites of injury are the cervical and thoracic areas. (
  • In studies of contusion SCI in the rat using mitogen-expanded cells, we have shown that SC transplantation at seven days after injury significantly fosters axon regeneration and myelination, improves host tissue preservation, 4 and reduces cavitation 4,14 in a thoracic SCI paradigm and increases numbers of preserved NeuN positive neurons rostral and caudal to the injury/graft site 17 after cervical SCI. (
  • Using mitogen expanded human SCs, placed as cellular cables in SCID mice and athymic female nude rats, the human SCs survive and are capable of enhancing axonal regeneration and forming myelin after transplantation in animals with sciatic nerve transection 19,20 or thoracic spinal cord transection. (
  • The primary end-point was to evaluate the safety through a one year follow-up when ahSCs were administered at one of three doses within 72 days of injury to participants with complete thoracic SCI. (
  • Injuries can be cervical 1-8 (C1-C8), thoracic 1-12 (T1-T12), lumbar 1-5 (L1-L5), or sacral (S1-S5). (
  • Vitale MG, Goss JM, Matsumoto H, Roye DP Jr. Epidemiology of pediatric spinal cord injury in the United States: years 1997 and 2000. (
  • SCIWORA (spinal cord injury without radiographic abnormality) in infants and children. (
  • Pang D. Spinal cord injury without radiographic abnormality in children, 2 decades later. (
  • NSCISC supports and directs the collection, management and analysis of the world's largest and longest spinal cord injury research database. (
  • Many scientists are optimistic that advances in research will someday make the repair of spinal cord injuries possible. (
  • Progress and adaptation is possible, but it is important to remember that there is not yet any repair for spinal cord injury, but research into this continues. (
  • In this printable worksheet, children read a passage about the human spinal cord, research spinal cord injuries, and write a proposal to raise funds for and awareness of spinal cord injuries. (
  • Hopefully, this technology could lead to new therapeutic strategies not only for patients with spinal cord injury but for those with various inflammatory diseases," said Jonghyuck Park, a U-M research fellow working with Shea. (
  • The Very Alternative Guide to Spinal Cord Injury is one of the first books to deliver this information in an evidence-based way and translates the research carried out at Loughborough University into a usable product that's going to have an impact on people's lives worldwide. (
  • A listing of Spinal Cord Injuries medical research trials actively recruiting patient volunteers. (
  • Research by University of Iowa professor, Richard Shields, Ph.D. can provide a ray of hope for a cure for patients with spinal cord injury (SCI). (
  • The goal is to make better recommendations to people with spinal cord injury, but the research will also translate into greater understanding of obesity in the general population as well. (
  • As a result, their body weight is comprised of much more fat and less muscle or bone than you would see in an able-bodied individual," says David Gater, M.D., Ph.D., director of Spinal Cord Injury Medicine at UMHS and director of the Spinal Cord Injury Research Center at the VA Ann Arbor Healthcare System. (
  • This research will allow us to develop a table or compendium of physical activity energy expenditures so a person with spinal cord injury can take a look at the table and figure out how many calories they're going to burn doing this activity for a certain period of time," Gater says. (
  • While Gater and his patients hope this research will lead to advances in spinal cord injury care, there's also potential for it to help with the overall obesity problem. (
  • Because of the unique impact of spinal cord injury on not just muscle mass but also whole body physiology, our research will have tremendous implications in able-bodied research, particularly as it relates to obesity and insulin sensitivity," Gater says. (
  • The 'International perspectives on spinal cord injuries' report developed in association with the International Spinal Cord Society and Swiss Paraplegic Research, will be launched tomorrow (December 3) to mark the International Day of Persons with Disabilities. (
  • The surprise awakening of Summers's nerve connections is part of a string of advances that has invigorated research into spinal-cord injuries. (
  • Emerson's mum knows just how important Spinal Research is not only for her and her family but for everyone who suffers from a spinal cord injury. (
  • Join us at Spinal Research and make a pledge to make a difference to families like Emerson's. (
  • The University of Alberta and the University of California, San Francisco are teaming up to launch the world's first Open Data Commons for preclinical Spinal Cord Injury research (ODC-SCI). (
  • The ODC-SCI will improve spinal cord injury research and treatment worldwide by reducing data bias and equipping scientists by making data more accessible. (
  • Students, academics, teachers and other people attending or interested in spinal-cord injury research. (
  • The findings 'look really, really impressive,' said Susan Howley, executive vice president and research director of the Christopher and Dana Reeve Foundation , a national spinal cord injury research and advocacy group named for the late 'Superman' actor and his wife. (
  • Newswise - In the hours and days following a spinal cord injury, the gears that control the body's internal clocks fall profoundly out of sync, impacting body temperature, hormone fluctuation, immunity and the timing of a host of other bodily processes, according to new CU Boulder research. (
  • Previous research has shown that in the aftermath of spinal cord injury people often have trouble regulating their body temperature and experience suppressed immunity. (
  • Inge Steuer and Pierre A. Guertin, "Spinal Cord Injury Research in Mice: 2008 Review," TheScientificWorldJOURNAL , vol. 9, pp. 490-498, 2009. (
  • Research update spinal cord injury : treatment update, the systems approach. (
  • Building on earlier research that uses targeted electrical stimulation of the spinal cord via a wireless implant to help paraplegics walk again , scientists from the federal technology institute in Lausanne (EPFL) and the University of Calgary carried out experiments to deliver electrical stimulation in the region containing the neural circuits that regulate blood pressure. (
  • This content was published on Nov 9, 2016 Nov 9, 2016 Swiss scientists have helped monkeys with spinal cord injuries regain control of non-functioning limbs in research which might one day lead to. (
  • Now, a joint research effort by UCL, the University of Zurich and University Hospital Balgrist has found evidence that patients already have irreversible tissue loss in the spinal cord within 40 days of injury. (
  • It is thus important to pursue research on all aspects of spinal cord injury, hoping that understanding basic mechanisms involved in spinal cord injury will continue to establish therapeutic strategies designed to alleviate such sensorimotor deficits and favor a better social reintegration of SCI patients. (
  • Martin Oudega also was a member of the International Center for Spinal Cord Injury at the Hugo W. Moser Research Institute of Kennedy Krieger. (
  • Spinal cord injury and male infertility-a review of current literature, knowledge gaps, and future research. (
  • At TIRR Memorial Hermann, we were one of the first facilities in the United States to establish a Spinal Cord Injury Center, and we are nationally recognized for our expertise in the management of all levels of spinal cord injury. (
  • Your ability to control your limbs after a spinal cord injury depends on two factors: the place of the injury along your spinal cord and the severity of injury to the spinal cord. (
  • While a partial or incomplete spinal cord injury means that the spinal cord transmits some information to move the limbs or provides some sensory information from the skin. (
  • We're able to perceive pain and move our limbs because of messages sent through the spinal cord. (
  • The preclinical evidence supports the concept that potential drug benefits will be due to 1) neuroprotection by limiting the degree of primary mechanical damage at the injury site, 2) augmentation of axonal outgrowth in the otherwise unfavorable post-injury microenvironment, and 3) facilitation of functional neural plasticity within surviving and newly formed neural circuits. (
  • Most spinal cord injuries trigger a cascade of chemical reactions in the spinal cord that collectively damage nearby cells and pathways, contributing to functional deficits including hind limb function. (
  • These results demonstrate that even a small contingent of spared spinal fibers can be leveraged for functional benefit. (
  • Hypothesis: Peripheral nerve transfers in patients with spinal cord injuries will improve hand function and provide improvement in patient quality of life and functional independence. (
  • The objectives of this study are to determine the nature of COX-2 expression in normal and traumatized rat spinal cord, and to determine the effects of selective COX-2 inhibition on functional recovery following spinal cord injury. (
  • Finally, using the highly selective COX-2 inhibitor, 1-[(4-methylsufonyl)phenyl]-3-tri-fluro-methyl-5-[(4-flur o)phenyl]prazole (SC58125), the effect of COX-2 inhibition on functional outcome following a spinal cord injury was determined. (
  • These data demonstrate that COX-2 mRNA and protein expression are induced by spinal cord injury, and that selective inhibition of COX-2 improves functional outcome following experimental spinal cord injury. (
  • This is the first functional study showing behavioral improvement below a spinal cord injury by the delivery of sialidase," says Ronald Schnaar, Ph.D ., a professor of pharmacology and molecular sciences at Johns Hopkins. (
  • The positive is that we have shown functional recovery in a relevant animal model of spinal cord injury," says Schnaar. (
  • A team of scientists at UCSF has made a critical discovery that may help in the development of techniques to promote functional recovery after a spinal cord injury. (
  • Spinal cord injury patients who are intubated have to be carefully monitored for VAP and treated with antibiotics if symptoms appear. (
  • What are the symptoms of a spinal cord injury? (
  • Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury. (
  • As the period of shock lessens, other symptoms appear, depending on the location of the injury. (
  • Generally, the higher up the level of the injury to the spinal cord, the more severe the symptoms. (
  • Be prepared to call your spinal care injury provider, , or other emergency services if you or the person with the spinal cord injury has the symptoms of autonomic dysreflexia , which causes sudden very high blood pressure . (
  • The causes of spinal cord injury are varied. (
  • Despite the advent of novel medical therapies for the treatment of these injuries, many patients with spinal cord injury remain severely incapacitated and dependent on their families and/or specialized nursing care. (
  • We discuss the diagnosis and management of these injuries as well as novel therapies on the horizon. (
  • Several clinical trials are testing cell replacement therapies to treat spinal cord injuries. (
  • Therapies to treat spinal cord injury are typically directed at one or more steps in this cascade. (
  • Unfortunately, there are no effective therapies for unstable blood pressure after spinal-cord injuries. (
  • Traumatic spinal cord injuries are increasing with the population, and incidence is higher in older individuals, according to a Vanderbilt study that was published in the June 9 issue of the Journal of the American Medical Association . (
  • Scientists at Lineage Cell Therapeutics hope to treat spinal cord injuries with an allogeneic therapy created from oligodendrocyte progenitor cells. (
  • Culley's team is running clinical trials of its technology in cancer, dry age-related macular degeneration, and spinal-cord injuries. (
  • This symposium aims at summarizing some of the scientific bases for current or planned clinical trials in patients with spinal cord injury (SCI). (
  • We wanted to take this further and look at the animal model most relevant to human spinal cord injury," says Schnaar. (
  • Advances in acute treatment of spinal cord injury include more sophisticated prehospital care, prompt recognition of the signs of spinal cord injury, safer transportation methods and active resuscitation both in the field and in the emergency department. (
  • Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. (
  • Directed by board-certified physiatrist specializing in the treatment of spinal cord injury. (
  • Psychologists and clinical neuropsychologists specialized in the treatment of spinal cord injury. (
  • An "incomplete" spinal cord injury involves preservation of motor or sensory function below the level of injury in the spinal cord. (
  • If all feeling (sensory) and all ability to control movement (motor function) are lost below the spinal cord injury, your injury is called complete. (
  • If you have some motor or sensory function below the affected area, your injury is called incomplete. (
  • Spinal cord injury (SCI) is an insult to the spinal cord resulting in a change, either temporary or permanent, in the cord's normal motor, sensory, or autonomic function. (
  • A careful evaluation of the injury and testing of sensory reflexes may be sufficient for a physician to rule out a spinal cord injury, but if the patient seems weak, confused or complains of neck pain, for example, the following emergency tests may be arranged. (
  • While the patient was unable to perceive mechanical sensory stimuli below spinal level C6, sensory stimuli to the hand robustly modulated neural activity in the contralateral primary motor cortex (M1). (
  • The spinal line is the significant piece of the focal sensory system of body or primary pathway for data that associates the mind and fringe sensory system. (
  • The neurologic level of injury is the lowest (most caudal) level with normal sensory and motor function. (
  • If you provide the right kind of sensory information into the spinal cord, it will recognize it and say, 'Oh, I know what that is. (
  • The diagnosis of such injuries relies upon radiological studies including x-rays, CAT scans and sometime magnetic resonance imaging studies (MRI) to visualize the damage. (
  • Diagnosis Spinal cord injuries are intense. (
  • Spinal Cord Injury Creates Unique Challenges in Diagnosis and Management of Catheter-Associated Urinary Tract Infection. (
  • Different parts of the spinal cord control different body parts. (
  • Improvements in the treatment of the chronic stages of the disease include the surgical management of syringomyelia, late post-traumatic deformity, and pain control has also been achieved.Increased survival for patients with spinal cord injury has focused the health care industry to develop strategies to enhance the quality of life via improvements, which range from lighter wheel chairs to development of fertility programs for the spinal cord injured patient. (
  • Most people with spinal cord injury experience chronic pain, and an estimated 20-30 per cent show clinically significant signs of depression. (
  • Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury. (
  • To assess the relationship between comorbid medical conditions and other health-related factors to mortality in chronic spinal cord injury (SCI). (
  • SYDNEY, Australia, Nov. 27 -- Patients with chronic neuropathic pain from spinal cord injuries experienced significant relief from the anticonvulsant and anxiolytic drug Lyrica (pregabalin), investigators here reported. (
  • They conducted a 12-week, multicenter study of paraplegic or quadriplegic patients with chronic neuropathic pain associated with their spinal cord injuries. (
  • A spinal cord injury - damage to any part of the spinal cord or nerves at the end of the spinal canal (cauda equina) - often causes permanent changes in strength, sensation and other body functions below the site of the injury. (
  • The higher up you damage the spinal cord, the more movement and sensation will be lost. (
  • Damage to the spinal cord in your neck will result in tetraplegia. (
  • That leads to the rapid death of neurons, damage to the insulating sheaths around nerve fibers that allow them to send signals, and the formation of a scar that blocks the regeneration of the spinal cord's nerve cells. (
  • On the flip side, injured mice that were given daily probiotic doses showed less spinal damage and were able to regain more hindlimb movement. (
  • A spinal cord injury is damage to the spinal cord. (
  • A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. (
  • In the event that you are experiencing any side effects of spinal string damage, it is essential to look for prompt restorative consideration. (
  • It can appear if nerve signs can go through the spinal line, or if a damage is obstructing the transmission. (
  • People often think of the effects of spinal cord injury in terms of the physical tissue damage itself," said senior author Linda Watkins, a distinguished professor of Behavioral Neuroscience at CU Boulder. (
  • You may also need tests such as MRI, CT, or X-ray, to show any damage to your spinal cord. (
  • You may be given contrast material to help show the damage to your spinal cord better. (
  • Movement of your spinal column may cause more damage to your spinal cord. (
  • We also show patients that they can still have a good quality of life even with spinal cord and nerve damage. (
  • Cell transplantation is a leading candidate therapy to repair tissue damage in the traumatically injured spinal cord. (
  • Whereas they do not repair all damage and do not migrate into intact parenchyma, they mediate their effects in the injury epicenter in this modified milieu. (
  • the level of injury, the severity of damage, and the individual's gender. (
  • The extent to which sexual function is impaired, however, depends on a variety of factors including the level of injury, the severity of damage to the spinal cord, and whether the individual is male or female. (
  • Separate areas of the spinal cord control muscle movements and sensations. (
  • Some study participants saw improvements in blood pressure, bowel and bladder control and sexual function - abilities that people with spinal-cord injuries often value more than the use of their legs. (
  • Neuroscientists Jerry Silver, left, and Yu-Shang Lee have developed a nerve-grafting method that enables rats with completely severed spinal cords to regain bladder control. (
  • Before the scientists can attempt the bladder repair in humans, they must show their method can re-grow nerves over longer distances in animals larger than rats, and that the fibers can overcome the entrenched obstacles of scarring in old spinal injuries, not just in fresh ones. (
  • Spinal cord injury patients who learn to effectively keep their bladder emptied at regular intervals greatly decrease the likelihood of bladder and kidney infection as well as pressure sore infections from bladder overflow on to the skin. (
  • Malignant spinal cord compression: a hospice emergency. (
  • Surgery can relieve spinal cord compression. (
  • They found evidence of spinal cord compression on MRI, but not CT, predicted a poorer recovery. (
  • Acute care appropriate to the level and severity of injury, degree of instability and presence of neural compression. (
  • Although the role of operative treatment in SCIWORA can be controversial, surgical alternatives such as decompression and fusion should be considered in selected patients with clinical and MRI evidence of persistent spinal cord compression and instability. (
  • Spinal cord compression occurs when a mass places pressure anywhere on the spinal cord down to the lower back. (
  • The Very Alternative Guide To Spinal Cord Injury 's 96 pages are packed with off-the-wall illustrations, photography and first-hand stories from people that have been through the life-changing experience. (
  • However, the people that deem it to be controversial are usually not people with a spinal injury. (
  • Our book was about providing something for spinal injured people first and foremost. (
  • The mission of the Kentucky Congress on Spinal Cord Injury (KCSCI) is to gather individuals with SCI from around the commonwealth to join in the discussion of critical issues that are important to them and to help draft agendas to be used to legislate changes in our commonwealth for people with SCI. (
  • Stephen Strittmatter, founder of ReNetX Bio and professor of neurology and neuroscience at Yale University, talks through his work to regrow nerve fibers in people with spinal cord injuries. (
  • As the nation fights a growing obesity epidemic, the problem is even more dramatic for people with spinal cord injury. (
  • And that means even when people with spinal cord injury exercise, they burn significantly fewer calories. (
  • Gater's team is looking at glucose tolerance, body composition and cardiovascular risk factors in people with spinal cord injury. (
  • About 60 percent of people with spinal cord injuries are overweight or obese. (
  • As many as 500.000 people suffer spinal cord injury each year, with survival rates worse in low-income and middle-income countries, according to a new study. (
  • People with spinal cord injuries are two to five times more likely to die prematurely, with worse survival rates in low- and middle-income countries, stated the 'International perspectives on spinal cord injuries' report which summarizes the best available evidence on the causes, prevention, care and lived experience of people with spinal cord injury. (
  • Correct understanding of spinal cord injury and positive attitudes towards people living with it. (
  • Injury to the spinal cord is a serious and potentially debilitating event that occurs in around 5 per 100,000 people in the Western world, mostly as a result of road traffic accidents. (
  • Now he was part of a pioneering experiment to test the power of electrical stimulation in people with spinal-cord injuries. (
  • The results have bolstered hopes for an improved quality of life, even for people who were paralysed years or decades ago, and the findings are upending conventional wisdom about spinal-cord injuries. (
  • For people suffering from a spinal cord injury, it is much more than just not being able to walk. (
  • People with these injuries need immediate ventilatory support. (
  • People with spinal cord injuries are at triple the usual risk for blood clots. (
  • Some people lead full and productive lives after a spinal cord injury. (
  • For many people with serious spinal cord injuries, lifetime medical expenses can reach into the millions. (
  • According to the National Spinal Cord Injury Association , an estimated 450,000 people in the U.S. currently live with a spinal cord injury (SCI). (
  • Our team is made up of spinal cord injury specialists, therapists, nurses, case managers and social workers dedicated to expert care of people with a spinal cord injury. (
  • People who have had a spinal cord injury (SCI) don't always have the ability to cough forcefully. (
  • An innovative training device being used at The Ohio State University Medical Center may lead to improved mobility and quality of life for people with spinal cord injuries. (
  • Since a spinal cord injury (SCI) affects virtually every system of the human body, many people who sustain SCI have serious concerns about how their injuries have affected their ability to participate in and enjoy a sexual relationship. (
  • the SCIA online Resource Library provides a wide variety of resources for people with spinal cord injuries and their families, containing articles and contact details of medical, support and advisory services. (
  • A regional information team also provides individual support and advice for people with spinal cord injury in coastal and inland NSW. (
  • In the United States, about 12,000 people a year survive a spinal cord injury. (
  • Your spinal cord is made up of nerves and nerve fibers. (
  • Electrical stimulation seems to help to amplify the messages being sent across the injury, and to re-establish these links. (
  • A team of Swiss and Canadian scientists have developed a targeted electrical stimulation treatment for patients with spinal-cord injuries that allows them to regain control of their blood pressure. (
  • Once damaged, nerves in the spinal cord normally cannot grow back and the only drug approved for treating these injuries does not enable nerve regrowth. (
  • Spinal cord regeneration hearing before the Subcommittee on Health and the Environment of the Committee on Interstate and Foreign Commerce, House of Representatives, Ninety-sixth C. (
  • Schwann cells (SCs), glial cells normally present in peripheral nerve, are responsible for axon regeneration after nerve injury. (
  • Based on their clear role in successful axon regeneration, the idea arose to test whether purified populations of SCs could mediate re-growth of axons and myelin in the damaged spinal cord, where they are not present normally. (
  • The traditional scientific approach in efforts to enhance CNS regeneration is to manipulate the biochemical environment of the cells at the site of the spinal cord injury, according to Basbaum. (