Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
The epithelium lining the seminiferous tubules composed of primary male germ cells (SPERMATOGONIA) and supporting SERTOLI CELLS. As SPERMATOGENESIS proceeds, the developing germ cells migrate toward the lumen. The adluminal compartment, the inner two thirds of the tubules, contains SPERMATOCYTES and the more advanced germ cells.
A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Contraceptive Agents, Male
The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
Follicle Stimulating Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Chromosomes, Human, Y
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Sertoli Cell-Only Syndrome
Meiotic Prophase I
Gene Expression Regulation, Developmental
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Seminal Plasma Proteins
Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.
Disorders of Sex Development
In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.
Cyclic AMP Response Element Modulator
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
Amino Acid Sequence
Reverse Transcriptase Polymerase Chain Reaction
In Situ Hybridization
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Sex Chromosome Disorders of Sex Development
A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).
Gene Expression Regulation
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Identification of a nuclear localization signal in activin/inhibin betaA subunit; intranuclear betaA in rat spermatogenic cells. (1/4031)Activin is a dimeric glycoprotein hormone that was initially characterized by its ability to stimulate pituitary FSH secretion and was subsequently recognized as a growth factor with diverse biological functions in a large variety of tissues. In the testis, activin has been implicated in the auto/paracrine regulation of spermatogenesis through its cognate cell membrane receptors on Sertoli and germ cells. In this study we provide evidence for intranuclear activin/inhibin betaA subunit and show its distribution in the rat seminiferous epithelium. We have shown by transient expression in HeLa cells of beta-galactosidase fusion proteins that the betaA subunit precursor contains a functional nuclear localization signal within the lysine-rich sequence corresponding to amino acids 231-244. In all stages of the rat seminiferous epithelial cycle, an intense immunohistochemical staining of nuclear betaA was demonstrated in intermediate or type B spermatogonia or primary spermatocytes in their initial stages of the first meiotic prophase, as well as in pachytene spermatocytes and elongating spermatids primarily in stages IX-XII. In some pachytene spermatocytes, the pattern of betaA immunoreactivity was consistent with the characteristic distribution of pachytene chromosomes. In the nuclei of round spermatids, betaA immunoreactivity was less intense, and in late spermatids it was localized in the residual cytoplasm, suggesting disposal of betaA before spermatozoal maturation. Immunoblot analysis of a protein extract from isolated testicular nuclei revealed a nuclear betaA species with a molecular mass of approximately 24 kDa, which is more than 1.5 times that of the mature activin betaA subunit present in activin dimers. These results suggest that activin/inhibin betaA may elicit its biological functions through two parallel signal transduction pathways, one involving the dimeric molecule and cell surface receptors and the other an alternately processed betaA sequence acting directly within the nucleus. According to our immunohistochemical data, betaA may play a significant role in the regulation of nuclear functions during meiosis and spermiogenesis. (+info)
Effects of spinal cord injury on spermatogenesis and the expression of messenger ribonucleic acid for Sertoli cell proteins in rat Sertoli cell-enriched testes. (2/4031)The study was an examination of the effects of spinal cord injury (SCI) on spermatogenesis and Sertoli cell functions in adult rats with Sertoli cell-enriched (SCE) testes. The effects of SCI on the seminiferous epithelium were characterized by abnormalities in the remaining spermatogenic cells during the first month after SCI. Three days after SCI, serum testosterone levels were 80% lower, while serum FSH and LH levels were 25% and 50% higher, respectively, than those of sham control SCE rats. At this time, the levels of mRNA for androgen receptor (AR), FSH receptor (FSH-R), and androgen-binding protein (ABP) were normal whereas those for transferrin (Trf) had decreased by 40%. Thereafter, serum testosterone levels increased, but they remained lower than those of the sham control rats 28 days after SCI; and serum FSH and LH levels returned to normal. The levels of mRNA for AR, ABP, and Trf exhibited a biphasic increase 7 days after SCI and remained elevated 28 days after SCI. FSH-R mRNA levels were also elevated 90 days after SCI. Unexpectedly, active spermatogenesis, including qualitatively complete spermatogenesis, persisted in > 40% of the tubules 90 days after SCI. These results suggest that the stem cells and/or undifferentiated spermatogonia in SCE testes are less susceptible to the deleterious effects of SCI than the normal testes and that they were able to proliferate and differentiate after SCI. The presence of elevated levels of mRNA for Sertoli cell FSH-R and AR, as well as of that for the Sertoli cell proteins, in the SCE testes during the chronic stage of SCI suggests a modification of Sertoli cell physiology. Such changes in Sertoli cell functions may provide a beneficial environment for the proliferation of the stem cells and differentiation of postmeiotic cells, thus resulting in the persistence of spermatogenesis in these testes. (+info)
hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis. (3/4031)MutS homologues have been identified in nearly all organisms examined to date. They play essential roles in maintaining mitotic genetic fidelity and meiotic segregation fidelity. MutS homologues appear to function as a molecular switch that signals genomic manipulation events. Here we describe the identification of the human homologue of the Saccharomyces cerevisiae MSH5, which is known to participate in meiotic segregation fidelity and crossing-over. The human MSH5 (hMSH5) was localized to chromosome 6p22-21 and appears to play a role in meiosis because expression is induced during spermatogenesis between the late primary spermatocytes and the elongated spermatid phase. hMSH5 interacts specifically with hMSH4, confirming the generality of functional heterodimeric interactions in the eukaryotic MutS homologue, which also includes hMSH2-hMSH3 and hMSH2-hMSH6. (+info)
The degenerative fate of germ cells not conforming to stage in the pubertal golden hamster testis. (4/4031)In the golden hamster (Mesocricetus auratus), pubertal establishment of spermatogenesis includes a defined period (d 26-30 of life) during which elongation of spermatids is selectively arrested. The resulting appearance of germ cell associations not conforming to stage and the phenomenon of desynchronisation-related germ cell degeneration are analysed both quantitatively and qualitatively by means of light and 'retrospective' electron microscopy. From d 26 onwards, the portion of tubules containing non-stage conforming germ cell associations gradually increases up to 37.5% of sectioned tubules on d 32. Concomitantly, the degree of desynchronisation rises to a maturational gap between spermatids and associated younger germ cells of 7 stages of the seminiferous epithelium cycle, i.e. of fully half a cycle. Beyond d 32, the frequency of desynchronised tubule segments decreases again. Some of the arrested round spermatids and, eventually, all belatedly elongating spermatids degenerate and are lost from the epithelium. Thus a regular maturation of advanced spermatids does not succeed under non-stage conforming conditions. Possibly it is not the desynchronisation between the associated germ cell generations and the spermatids by itself that impedes normal further development of the latter cells. Instead this may be due to the maturational delay of the stage-aberrant cells by several stages compared to the seminiferous epithelium as a whole and, especially, in relation to the stage-conditioned functional state of the neighbouring Sertoli cells. (+info)
The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction. (5/4031)Mice homozygous for tAE5, a recessive allele at the complex T-locus, are characterized by their unique short-tailed phenotype as well as by runting and low fertility. Histological and histochemical studies of the lymphoid and reproductive systems disclosed structural changes in the mutant spleen resembling those found in autoimmune conditions. Involution of the mutant thymus was greatly accelerated compared to normal. Necrotic changes occurred during spermiogenesis whereas ovarian structure was normal in mutants. The possible mechanisms of the mutant effects are discussed in the framework of other similar syndromes and the mode of action of alleles at the complex T-locus. (+info)
Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis. (6/4031)The Hsp90 chaperone protein maintains the activities of a remarkable variety of signal transducers, but its most critical functions in the context of the whole organism are unknown. Point mutations of Hsp83 (the Drosophila Hsp90 gene) obtained in two different screens are lethal as homozygotes. We report that eight transheterozygous mutant combinations produce viable adults. All exhibit the same developmental defects: sterile males and sterile or weakly fertile females. We also report that scratch, a previously identified male-sterile mutation, is an allele of Hsp82 with a P-element insertion in the intron that reduces expression. Thus, it is a simple reduction in Hsp90 function, rather than possible altered functions in the point mutants, that leads to male sterility. As shown by light and electron microscopy, all stages of spermatogenesis involving microtubule function are affected, from early mitotic divisions to later stages of sperm maturation, individualization, and motility. Aberrant microtubules are prominent in yeast cells carrying mutations in HSP82 (the yeast Hsp90 gene), confirming that Hsp90 function is connected to microtubule dynamics and that this connection is highly conserved. A small fraction of Hsp90 copurifies with taxol-stabilized microtubule proteins in Drosophila embryo extracts, but Hsp90 does not remain associated with microtubules through repeated temperature-induced assembly and disassembly reactions. If the spermatogenesis phenotypes are due to defects in microtubule dynamics, we suggest these are indirect, reflecting a role for Hsp90 in maintaining critical signal transduction pathways and microtubule effectors, rather than a direct role in the assembly and disassembly of microtubules themselves. (+info)
Y chromosome and male infertility. (7/4031)Recent genome analysis of the Y chromosome has increased the number of genes found on this chromosome markedly. Many of these genes in the part of the Y chromosome that does not undergo recombination with the X chromosome are members of gene families. Evolutionary considerations imply that genes on the Y chromosome will degenerate unless they have male advantageous or female deleterious functions. Spermatogenesis is an example of a male advantageous function and genes in three regions of the human Y chromosome have been promoted as candidate male fertility factors. (+info)
Role of heat shock protein HSP70-2 in spermatogenesis. (8/4031)The HSP70 heat-shock proteins are molecular chaperones that assist other proteins in their folding, transport and assembly into complexes. Most of these proteins are either constitutively expressed or their expression is induced by heat shock and other stresses. However, two members of the Hsp70 family (HSP70-2 and HSC70T in mice) are regulated developmentally and expressed specifically in spermatogenic cells. The HSP70-2 protein is synthesized during the meiotic phase of spermatogenesis and is abundant in pachytene spermatocytes. The knockout approach was used to determine whether HSP70-2 is a chaperone for proteins involved in meiosis. Male mice lacking HSP70-2 were infertile while females lacking HSP70-2 were fertile. Spermatogenic cell development was arrested in prophase of meiosis I at the G2-M-phase transition and late pachytene spermatocytes were eliminated by apoptosis, resulting in an absence of spermatids. HSP70-2 is required for Cdc2 to form a heterodimer with cyclin B1, suggesting that it is a chaperone necessary for the progression of meiosis in the germ cells of male mice. HSP70-2 is also associated with the synaptonemal complex and desynapsis is disrupted in male mice lacking this protein. Homologues of HSP70-2 are present in the testes of many animals, suggesting that the role of this spermatogenic cell chaperone is conserved across phyla. (+info)
Mammalian spermatogenesis consists of many cell types and biological processes and - Synthesis and Evaluation of Novel PI3K...
Mammalian spermatogenesis consists of many cell types and biological processes and serves as an excellent model for studying gene regulation at transcriptional and post-transcriptional levels. identified five major regulatory mechanisms termed transcript only, transcript degradation, translation repression, translation de-repression, and protein degradation based on changes in protein level relative to changes in mRNA level at the mitosis/meiosis transition and the meiosis/post-meiotic development transition. We found that post-transcriptional regulatory mechanisms are related to the generation of piRNAs and antisense transcripts. Our results provide a valuable inventory of proteins produced during mouse spermatogenesis and contribute to elucidating the mechanisms of the post-transcriptional regulation of gene expression in mammalian spermatogenesis. Spermatogenesis in animals is usually a complex yet tightly regulated developmental process that involves many cell types. Similar to other ...
asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis<...
TY - JOUR. T1 - asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. AU - Anderson, Michael A.. AU - Jodoin, Jeanne N.. AU - Lee, Ethan. AU - Hales, Karen G.. AU - Hays, Thomas S.. AU - Lee, Laura A.. PY - 2009/6/1. Y1 - 2009/6/1. N2 - Spermatogenesis uses mitotic and meiotic cell cycles coordinated with growth and differentiation programs to generate functional sperm. Our analysis of a Drosophila mutant has revealed that asunder (asun), which encodes a conserved protein, is an essential regulator of spermatogenesis. asun spermatocytes arrest during prophase of meiosis I. Strikingly, arrested spermatocytes contain free centrosomes that fail to stably associate with the nucleus. Spermatocytes that overcome arrest exhibit severe defects in meiotic spindle assembly, chromosome segregation, and cytokinesis. Furthermore, the centriole-derived basal body is detached from the nucleus in asun postmeiotic spermatids, resulting in abnormalities later in ...
Mammalian spermatogenesis is certainly a complicated differentiation process that occurs in
Mammalian spermatogenesis is certainly a complicated differentiation process that occurs in many stages in the seminiferous tubules of the testes. attained from entire testes to end up being separated with a water lean. The STA-PUT technique, exhibited right here, uses a linear BSA gradient and basic sedimentation to individual spermatogenic cells centered on size and mass6-9. The STA-PUT technique offers many advantages over the additional two most broadly utilized strategies to individual spermatogenic cell types: FACS and elutriation10-13. The STA-PUT equipment needs just many items of specific glassware put together in a chilly space or huge refrigerator. Therefore, it is usually much less costly than using a cell sorter or an elutriator. The STA-PUT technique produces higher quantities of cells per cell type and testis than can become categorized by FACS in a similar period framework, although the chastity of each cell 158013-43-5 supplier populace is usually not really as high as those ...
Developmental Genetics of Secretory Vesicle Acidification During Caenorhabditis elegans Spermatogenesis | Genetics
Much prior work has shown that C. elegans spermatogenesis requires the proper morphogenesis and function of its MO secretory vesicles. While many mutants that affect the ultrastructure and cellular position of MO secretory vesicles are known (reviewed by LHernault 2006, 2009), little is known about how the affected proteins alter cell physiology. In this article, we show that morphogenesis of MO secretory vesicles is associated with a physiological transition when this compartment becomes acidified. This acidification is apparently synchronous and occurs coincident with spermatid budding from the residual body, which is when each FB-MO matures into a MO secretory vesicle (Figure 1, D and E). This acidification requires the V-ATPase, which is composed of a V0 sector that forms a pore in the membrane and a V1 sector that hydrolyzes ATP to provide the electromotive force for proton transport through V0 (reviewed by, e.g., Toei et al. 2010). spe-5 mutants do not show this MO acidification. In ...
HKU Scholars Hub: Nitric Oxide/Nitric Oxide Synthase, Spermatogenesis, and Tight Junction Dynamics
During spermatogenesis, preleptotene and leptotene spermatocytes, residing in the basal compartment of the seminiferous epithelium, must traverse the blood-testis barrier (BTB) to gain entry to the adluminal compartment for further development at late stage VIII and early stage IX of the epithelial cycle. As such, the timely opening and closing of the BTB is crucial to spermatogenesis. A compromise in this process can lead to infertility. Moreover, the BTB is unique in its relative localization in the seminiferous epithelium compared to the tight junctions (TJs) found in other epithelia. Sertoli cell TJs are situated near the basal lamina in the testis, closest to the basement membrane (a modified form of extracellular matrix [ECM]), unlike TJs found in other epithelia, which are found nearest the apical portion of an epithelium, farthest away from ECM. Needless to say, BTB function in the testis is maintained by intricate regulatory mechanisms. In addition to hormones and cytokines, nitric ...
5.2.1 Spermatogenesis (Animation) -At what point in life do spermatogonia begin to undergo meiosis? -How many spermatozoa result from a single primary spermatocyte? -What is spermiogenesis? -What are the structural components of a mature spermatozoon? -How long does it takes for a primary spermatocyte to become a mature spermatozoon? -What testicular hormone is required for maintenance of spermatogenesis? -How do chronically high levels of anabolic steroids such as testosterone suppress spermatogenesis ...
Martin Asser Hansen: Gene families and spermatogenesis
The title of my Ph.D. thesis was Bioinformatic Analysis of Gene Families in Mouse and Human Spermatogenesis. Initially we determined gene expression profiles during the development of spermatogenesis in newborn mice. I wrote a data integration system to incorporate data from differnt sources including Differential Display, DNA array, and in situ hybridization data. We were able to show that the first wave of spermatogenesis was constituted of three major clusters of expression originating from Sertoli cells, Pachytene germ cells, and spermatids - and that all genes expressed could be associated to one or more of these clusters. This made it possible to determine the germ cell composition of the growing testis from total RNA and work is still ongoing to utilize this to located disrupted germ cell populations that may be caused by hormone like agents such as phthalates, parabenes, and pesticides - leading to impaired testicular function ...
Difference Between Spermatogenesis and Spermiogenesis | Definition, Stages, Types | clickspay.ru
What is the difference between Spermatogenesis and Spermiogenesis? Spermiogenesis consists of a differentiation process while spermatogenesis consists of ..
AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis. - Semantic Scholar
Mammalian spermatogenesis is regulated by coordinated gene expression in a spatiotemporal manner. The spatiotemporal regulation of major sperm proteins plays important roles during normal development of the male gamete, of which the underlying molecular mechanisms are poorly understood. A-kinase anchoring protein 3 (AKAP3) is one of the major components of the fibrous sheath of the sperm tail that is formed during spermiogenesis. In the present study, we analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis. Results showed that the transcription of Akap3 precedes its protein synthesis by about 2 wk. Nascent AKAP3 was found to form protein complex with PKA and RNA binding proteins (RBPs), including PIWIL1, PABPC1, and NONO, as revealed by coimmunoprecipitation and protein mass spectrometry. RNA electrophoretic gel mobility shift assay showed that these RBPs bind sperm-specific mRNAs, of which proteins are synthesized
Spermatozoa Development - Embryology
de Rooij DG. (2017). The nature and dynamics of spermatogonial stem cells. Development , 144, 3022-3030. PMID: 28851723 DOI. Griswold MD. (2016). Spermatogenesis: The Commitment to Meiosis. Physiol. Rev. , 96, 1-17. PMID: 26537427 DOI. Talwar P & Hayatnagarkar S. (2015). Sperm function test. J Hum Reprod Sci , 8, 61-9. PMID: 26157295 DOI. Yoshida S. (2010). Stem cells in mammalian spermatogenesis. Dev. Growth Differ. , 52, 311-7. PMID: 20388168 DOI. Hogarth CA & Griswold MD. (2010). The key role of vitamin A in spermatogenesis. J. Clin. Invest. , 120, 956-62. PMID: 20364093 DOI. Ruwanpura SM, McLachlan RI & Meachem SJ. (2010). Hormonal regulation of male germ cell development. J. Endocrinol. , 205, 117-31. PMID: 20144980 DOI. Hermo L, Pelletier RM, Cyr DG & Smith CE. (2010). Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes. Microsc. Res. Tech. , 73, 241-78. PMID: 19941293 DOI. ...
Sperm morphogenesis in wild-type and fertilization-defective mutants of Caenorhabditis elegans. | JCB
Taking advantage of conditions that allow spermatogenesis in vitro, the timing and sequence of morphological changes leading from the primary spermatocyte to the spermatozoon is described by light and electron microscopy. Together with previous studies, this allows a detailed description of the nuclear, cytoplasmic, and membrane changes occurring during spermatozoan morphogenesis. By comparison with wild type, abnormalities in spermatogenesis leading to aberrant infertile spermatozoa are found in six fertilization-defective (fer) mutants. In fer-1 mutant males, spermatids appear normal, but during spermiogenesis membranous organelles (MO) fail to fuse with the sperm plasma membrane and a short, though motile. pseudopod is formed. In fer-2, fer-3, and fer-4 mutants, spermatids accumulate 48-nm tubules around their nuclei where the centriole and an RNA containing perinuclear halo would normally be. In all three mutants, spermatids still activate to spermatozoa with normal fusion of their MOs, but ...
SirT1 is required in the male germ cell for differentiation and fecundity in mice | Development
SirT1 whole body KO mice have been shown to lack pituitary hormones for reproduction, and fertility in females can be rescued by administration of these hormones (Kolthur-Seetharam et al., 2009; McBurney et al., 2003). The present study demonstrates that SirT1 is necessary in male germ cells for normal spermatogenesis. Mice lacking SirT1 in male germ cells displayed decreased sperm counts, and many of their spermatozoa have aberrant morphology and increased DNA lesions. These defects explain why male germ cell SirT1 KO mice sire only ∼15% of the progeny number that are sired by control mice. Our findings indicate that SirT1 plays an additional essential role in male germ cells.. Cells in the mid-to-late stages of meiosis I contain the highest levels of SirT1, whereas it is present at moderate levels in differentiating spermatogonia and haploid round spermatids. Without SirT1, the appearance of pachytene cells in seminiferous tubules is delayed, demonstrating that SirT1 is required for ...
What is Spermatogenesis? - Definition from FertilitySmarts
Spermatogenesis Definition - Spermatogenesis is the process of sperm development. Sperm, the male sex cells, are essential for reproduction, and any...
spe-10 Encodes a DHHC-CRD Zinc-Finger Membrane Protein Required for Endoplasmic Reticulum/Golgi Membrane Morphogenesis During...
The spe-10 gene encodes a novel, predicted four-pass integral membrane protein that contains a highly conserved DHHC-CRD motif (Bohm et al. 1997; Putilina et al. 1999). If a potential glycosylation site following TM4 is utilized, then the N-terminal region, the DHHC-CRD zinc-finger, and the C-terminal region should all face the lumen of the MO (Figure 6A). This orientation would allow the N-linked glycans to face the exterior of the cell surface when the MOs fuse to the plasma membrane. Northern hybridizations comparing oogenesis-specific and spermatogenesis-specific transcripts indicate that the spe-10 mRNA is found only in worms that are actively engaged in spermatogenesis (Figure 4B). SPE-10 localizes within the lysosome-like FB-MOs and segregates to spermatids as they bud from the residual body during C. elegans spermatogenesis (Figure 8). These results suggest that a lack of wild-type SPE-10 in the FB-MOs of spe-10 mutants probably causes the previously described sperm ultrastructural ...
NIOSHTIC-2 Publications Search - 00131435 - Assessment of disorders of spermatogenesis.
Methods of assessing spermatogenesis disorders are described. The biological basis of male infertility or sub fertility is not well understood, due to the lack of research on this topic and the primitive state of current diagnostic procedures. For most males afflicted with spermatogenesis disorders, there is no therapy or rehabilitative method. A careful and expert semen evaluation provides import
P8 Atherosclerosis-related disturbances of spermatogenesis: lessons from the ApoE-/-/LDL receptor-/- knockout mouse model and...
Generally, age-related testicular changes are associated with an increase of germ cell degeneration, decline of spermatogenesis and androgen decline resulting in a gradual decrease of sperm count. Unfortunately, an association of these findings to vascular atherosclerotic alterations has never been investigated systematically, although arterial lesions in testicular biopsies of azoospermic men have been described already 30 years ago.
Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells ...
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Human Spermatogenesis Associated 24 (SPATA24) Protein (His tag), Recombinant | ABIN3077430
Recombinant Spermatogenesis Associated 24 (SPATA24) Protein (His tag). Species: Human. Source: Escherichia coli (E. coli). Order product ABIN3077430.
HP1γ function is required for male germ cell survival and spermatogenesis | Epigenetics & Chromatin | Full Text
The similarity of the Cbx3hypo/hypospermatogenesis defect to Dnmt3L and Miwi2 mutants [21, 22] prompted us to investigate whether there were any changes in the expression of retrotransposon expression in the mutant testes. For this, we used a polyclonal antibody to the L1-encoded ORF1 protein . ORF1p is required for L1 transposition, and its levels of expression are increased in germ cells, as the L1 transposons become de-repressed [24, 25]. Using this antibody, we found that 45% of the tubules in Cbx3hypo/hypotestes that contained germ cells were positive by immunohistochemistry for ORF1 protein expression, compared with 5% in wild-type testes (see Additional file 6 and 7, Figure s6 and Figure s7). Again, this indicates that the Cbx3hypo/hypomutation may affect the same silencing pathway that is affected in the Dnmt3L and Miwi2 mutants [21, 22].. We next investigated whether the Cbx3 hypo mutation affects the expression of the other two HP1 isotypes, HP1α and HP1β. Accordingly, we stained ...
Regulation of Spermatogenesis by X-linked miRNAs - Wei Yan
Meiotic sex chromosome inactivation (MSCI) during spermatogenesis is characterized by transcriptional silencing of genes on both the X and Y chromosomes in mid...
Spermatogenesis | SpringerLink
Deficiencies in sperm function are usually the result of spermatogenic defects. Spermatogenesis is a biologically complex and essential process during which spermatogonia undergo meiotic recombination
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice | JCB
Recent studies have shown that TDRDs are critical regulators of spermatogenesis in mice (Pan et al., 2005; Chuma et al., 2006; Shoji et al., 2009; Vasileva et al., 2009). Based on their expression and the spermatogenic stages by which the phenotypes manifest in mutant animals, TDRDs can be classified into two groups: those that show expression from embryonic germ cells and are critical for progression of the meiotic prophase, and those that begin their expression in neonatal germ cells, show prominent expression from the pachytene stage onwards, and are essential for spermiogenesis. The first group includes TDRD1 and TDRD9 (Chuma et al., 2006; Shoji et al., 2009) and the second group includes TDRD4/RNF17 and TDRD6 (Pan et al., 2005; Vasileva et al., 2009). A key phenotype of the first group of mutants is the derepression of retrotransposons, especially the LINE-1 elements, and the consequent meiotic catastrophe (Chuma et al., 2006; Reuter et al., 2009; Shoji et al., 2009), whereas the second ...
pTestis - Phosphorylation in Testis
Spermatogenesis, the sperm-generating process, is a complex process involving mitosis of spermatogonia, meiosis of spermatocytes and spermiogenesis of spermatids. The protein expression levels have been well studied by high-throughput proteomic studies, however, the PTMs including phosphorylation have been less explored. Using advanced mass spectrometry, we successfully identified 17,971 phosphorylation sites of 4131 phosphoproteins from adult mouse testes. Gene ontology annotation reveals that those phosphoproteins mainly function in spermatogenesis, mitosis, transcription, translational regulation and RNA splicing. Substrate and kinase annotation reveals important roles of PLK family kinases in the testicular phosphoproteome. Using small molecule inhibitor of PLKs, we found that PLKs play important functions in the spermatocyte cell line GC2. This mouse testicular phosphoproteome can be a rich resource for the study of mechanisms of spermatogenesis ...
Important stages of spermatogenesis relative to the tra | Open-i
Important stages of spermatogenesis relative to the transcription. Here, we commence with the differentiation of prespermatogonial gonocytes in spermatogonia. S
Stage-dependent enzymatic activities in spermatogenesis of mice with the standard karyotype and of chromosomal variants with...
TY - JOUR. T1 - Stage-dependent enzymatic activities in spermatogenesis of mice with the standard karyotype and of chromosomal variants with impaired fertility. AU - Redi, C. A.. AU - Hilscher, B.. AU - Winking, H.. PY - 1983. Y1 - 1983. UR - http://www.scopus.com/inward/record.url?scp=0021064209&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0021064209&partnerID=8YFLogxK. M3 - Article. C2 - 6139043. AN - SCOPUS:0021064209. VL - 15. SP - 322. EP - 330. JO - Andrologia. JF - Andrologia. SN - 0303-4569. IS - 4. ER - ...
SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2)
SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2), Authors: Flavia R Mangone, Ana Carolina Pavanelli, Maria A. Nagai. Published in: Atlas Genet Cytogenet Oncol Haematol.
Difference Between Oogenesis and Spermatogenesis | Difference Between
Oogenesis vs Spermatogenesis Sex can be one of the most pleasurable things a couple can do. Some do it for fun while some do it for procreation. All of the
Download Spermatogenesis Methods And Protocols 2013
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Spermatogenesis Disorders ᐉ diagnostics, treatment in Reproductive Medical Center BOGOLIUBY, Lutsk
Spermatogenesis Disorders ❱❱❱ reasons, symptoms, treatment ✅ BOGOLIUBY MC - Medicine of international level! Lutsk ❤ Modern methods of diagnosis ✅ To make an appointment ☎ ❱❱❱ (099) 44-55-404 ☀ Lutsk, Bogoliuby
Spermatogenesis:new: SpermatogenesisMethods and ProtocolsSeries: Methods in Molecular Biology, Vol. 927 Barnard, Lori; Aston, Kenneth I. (Eds.)2013
Spermatogenesis arrest Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Spermatogenesis arrest information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Citation Machine: Spermatogenesis format citation generator for website
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your website in Spermatogenesis format for free.
Citation Machine: Spermatogenesis format citation generator for patent
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your patent in Spermatogenesis format for free.
Spermatogenesis Compile http://i.imgur.com/S2BCwjP.jpg Pages: Publisher: -- Edition: 2010 Language: English ISBN:
Sperm production, SEM - Stock Image C016/9765 - Science Photo Library
Sperm production. Coloured scanning electron micrograph (SEM) of sperm cells (spermatozoa) in the seminiferous tubules of the testis. This is the site of spermatogenesis (sperm production). Each sperm cell consists of a head (grey), which contains the genetic material that fertilises the female egg cell, and a tail (blue), which propels the sperm. The heads of the sperm are buried in Sertoli cells (pink), which nourish the developing sperm. - Stock Image C016/9765
Sperm production, SEM - Stock Image C003/0692 - Science Photo Library
Sperm production. Coloured scanning electron micrograph (SEM) of sperm cells (spermatozoa) in the seminiferous tubules of the testis. This is the site of spermatogenesis (sperm production). Each sperm cell consists of a head (green orange), which contains the genetic material that fertilises the female egg cell, and a tail (blue), which propels the sperm. The heads of the sperm are buried in Sertoli cells (yellow and orange), which nourish the developing sperm. - Stock Image C003/0692
New papers in MBE, GBE, and Evolution! - The Good Lab
We have published three new studies related to hybridization and speciation. Our study on the disruption of gene expression during spermatogenesis in mice led by postdoc Erica Larson has been accepted in Molecular Biology and Evolution. We present the most detailed assessment of hybrid gene expression across mouse spermatogenesis to date. Aided by novel FACS cell-specific expression data, we find evidence for disruption of X chromosome regulation at multiple stages of spermatogenesis.. Our study on the disruption of gene expression during placental development in hamsters led by recent PhD graduate Tom Brekke has been published in Evolution. In this work we present evidence for extensive disruption of genomic imprinting associated with placental and embryonic overgrowth in hybrid dwarf hamsters. Finally, a collaborative study examining the dynamics of mitochondrial introgression in chipmunks has been published in Genome Biology and Evolution. This work was led by lab postdoc Brice Sarver as part ...
CYP1A1 based on metabolism of xenobiotics by cytochrome P450 regulates chicken male germ cell differentiation | Springer for...
This study aimed to explore the regulatory mechanism of metabolism of xenobiotics by cytochrome P450 during the differentiation process of chicken embryonic stem cells (ESCs) into spermatogonial stem...
Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis |...
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.. Please dont hesitate to contact the Editorial Office if you have any questions or concerns.. ...
PPT - Figure S1 PowerPoint Presentation - ID:118047
Dsim\rux-PA. Dsec\rux-PA. Dere\rux-PA. Dyak\rux-PA. Dana\GF22065-PA. Dwil\GK19724-PA. Dvir\GJ16032-PA. Dpse\GA18118-PA. Dper\GL14959-PA. Dmoj\GI16487-PA. Dgri\GH17896-PA. Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex Slideshow 118047 by Melvin
Dynamic analysis of testicular histology of Meig1-defic | Open-i
Dynamic analysis of testicular histology of Meig1-deficient mice during the first wave of spermatogenesis. Representative testicular sections stained with Hemat
Our research explores sperm development, structure and function. Our overarching aim is to improve our understanding of the...
Our research explores sperm development, structure and function. Our overarching aim is to improve our understanding of the processes of sperm formation and function using a variety of laboratory techniques and models.
Covid-19 affects testicles, studies show
Another study recently published by the same group of researchers and also supported by FAPESP indicated that SARS-CoV-2 invades all types of testicular cells, causing lesions that can impair hormonal function and male fertility. Through a project coordinated by professors from the Faculty of Medicine of USP Paulo Saldiva and Marisa Dolhnikoff, minimally invasive autopsy techniques were used to extract testicular tissue samples from 11 men, aged between 32 and 88 years, who died at Hospital das Clinics of the Faculty of Medicine of USP due to severe covid-19.. The results of the analyzes indicated a series of testicular lesions that can be attributed to inflammatory alterations that reduce the production of sperm (spermatogenesis) and hormones. What immediately caught our attention in these patients who died as a result of covid-19 was the drastic reduction in spermatogenesis. Even the youngest, of childbearing age, had practically no sperm, says Amaro Nunes Duarte Neto, infectologist and ...
SPATA2L (spermatogenesis associated 2-like) - KOMP (Knockout Mouse Project)
The KOMP Repository Collection is located at the MMRRC at the University of California Davis. Question? Comments? Please contact us at [email protected], US 1-888-566-7643 or International +1-530-754-6677 ...
Ovary, testis, oogenesis and spermatogenesis - The A Level Biologist - Your Hub
This is your stop for learning resources, extra info and essential dates and documents. Ive scoured the world just to bring you, the A Level biologists, all you need to succeed and enjoy your Biology A Level.
Biology of Spermatogenesis and Spermatozoa in Mammals | Rent 9780387171432 | 0387171436
With our dedicated customer support team, 30-day no-questions-asked return policy, and our price match guarantee, you can rest easy knowing that were doing everything we can to save you time, money, and stress.. ...
Browsing Research in Reproduction and Contraception, Center for by Author Holdcraft, Robert W.
In a screen for RNA binding proteins expressed during murine spermatogenesis, we cloned a novel, ancient zinc finger protein possessing a region common to a small class of RNA binding proteins. Zfr (zinc ...
Browsing Research in Reproduction and Contraception, Center for by Subject Blotting, Western
In a screen for RNA binding proteins expressed during murine spermatogenesis, we cloned a novel, ancient zinc finger protein possessing a region common to a small class of RNA binding proteins. Zfr (zinc ...
Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest<...
TY - JOUR. T1 - Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest. AU - Takubo, Keiyo. AU - Ohmura, Masako. AU - Azuma, Masaki. AU - Nagamatsu, Go. AU - Yamada, Wakako. AU - Arai, Fumio. AU - Hirao, Atsushi. AU - Suda, Toshio. PY - 2008/2/7. Y1 - 2008/2/7. N2 - Mammalian spermatogenesis is maintained by stem cell capacity within undifferentiated spermatogonial subpopulation. Here, using a combination of surface markers, we describe a purification method for undifferentiated spermatogonia. Flow cytometric analysis revealed that this population is composed of Plzf-positive cells and exhibits quiescence and the side population phenotype, fulfilling general stem cell criteria. We then applied this method to analyze undifferentiated spermatogonia and stem cell activity of Atm-/- mice. Atm-/- testis shows progressive depletion of undifferentiated spermatogonia accompanied by cell-cycle arrest. In Atm-/- undifferentiated spermatogonia, a ...
TPR-containing protein involved in spermatogenesis | definition of TPR-containing protein involved in spermatogenesis by...
Looking for online definition of TPR-containing protein involved in spermatogenesis in the Medical Dictionary? TPR-containing protein involved in spermatogenesis explanation free. What is TPR-containing protein involved in spermatogenesis? Meaning of TPR-containing protein involved in spermatogenesis medical term. What does TPR-containing protein involved in spermatogenesis mean?
Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide...
Very recent publications in Gut and elsewhere1 2 suggest that gut microbiota affects fertility. The application of faecal microbiota transplantation (FMT) to modify fertility is an emerging novel area of interest.3 FMT from women with polycystic ovary syndrome (PCOS) leads to the disruption of ovarian function and a decrease in fertility which indicates that modification of gut microbiota may be a valuable approach in the management of PCOS.2 FMT of gut microbes, that developed under a high-fat diet, into mice on a normal diet leads to the disruption of spermatogenesis and a reduction of sperm motility,1 which highlights that restoring gut microbiota may be a means of improving disturbed male infertility caused by environmental factors.1 However, to date, there are no reports that address improvements of fertility following FMT. In a recent study,4 we found that busulfan damages spermatogenesis and sperm quality, and disturbs gut microbiota as found in many other studies.5 6 Alginate ...
Spermatogonial stem cell - Wikipedia
A spermatogonial stem cell (SSC) is a subtype of undifferentiated spermatogonium. During foetal development gonocytes develop from primordial germ cells and following this SSCs develop from gonocytes in the testis. SSCs are the early precursor for spermatozoa and are responsible for the continuation of spermatogenesis in adult mammals. The stem cells are capable of dividing into more SSCs which is vital for maintaining the stem cell pool. Alternatively they go on to differentiate into spermatocytes, spermatids and finally spermatozoa. One SSC is the precursor for multiple spermatozoa and therefore SSCs are much less numerous in the testes than cells undergoing spermatogenesis. In Humans Undifferentiated spermatogonia can be split into 2 groups; A Dark (Ad) and A Pale (Ap) Ad spermatogonia are reserve stem cells. These cells are capable of dividing to produce more SSCs but usually do not. Ap spermatogonia are actively dividing to maintain the stem cell pool. B1-B4 spermatogonia encompass the ...
Characterization of BRD4 during mammalian post-meiotic sperm developme by Jessica M. Bryant, Greg Donahue et al.
During spermiogenesis, the post-meiotic phase of mammalian spermatogenesis, transcription is progressively repressed as nuclei of haploid spermatids are compacted through a dramatic chromatin reorganization involving hyper-acetylation and replacement of most histones with protamines. Although BRDT functions in transcription and histone removal in spermatids, it is unknown whether other BET family proteins play a role. Immunofluorescence of spermatogenic cells revealed BRD4 in a ring around the nuclei of spermatids containing hyper-acetylated histones. The ring lies directly adjacent to the acroplaxome, the cytoskeletal base of the acrosome, previously linked to chromatin reorganization. The BRD4 ring does not form in acrosomal mutant mice. ChIP sequencing in spermatids revealed enrichment of BRD4 and acetylated histones at the promoters of active genes. BRD4 and BRDT show distinct and synergistic binding patterns, with a pronounced enrichment of BRD4 at spermatogenesis-specific genes. Direct association
Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures | BMC Research Notes...
Germ cell development involves formation of the spermatogenic or oogenic lineages from the bipotential primordial germ cells. Signaling mechanisms in the fetal testis and ovary determine whether germ cells enter the male or female developmental pathway, respectively. These signaling processes underpin an important phase of germ cell development, disruption of which can lead to failed germ cell function resulting in infertility or the formation of germ cell tumours. In this study we have developed a small molecule screening protocol combined with flow cytometry to identify signaling pathways that direct male-specific development of germ cells. Here we provide a detailed method for this screening protocol, which we have used to identify signaling pathways important for male germ cell development. This method will be of particular use in screening inhibitors of signaling pathways, endocrine disruptors or other chemicals for their ability to disrupt testis and germ cell development, thereby providing
Androgen receptor signalling in Vascular Endothelial cells is dispensable for spermatogenesis and male fertility | BMC Research...
Androgen signalling is essential both for male development and function of the male reproductive system in adulthood. Within the adult testis, Germ cells (GC) do not express androgen receptor (AR) suggesting androgen-mediated promotion of spermatogenesis must act via AR-expressing somatic cell-types. Several recent studies have exploited the Cre/lox system of conditional gene-targeting to ablate AR function from key somatic cell-types in order to establish the cell-specific role of AR in promotion of male fertility. In this study, we have used a similar approach to specifically ablate AR-signalling from Vascular Endothelial (VE) cells, with a view to defining the significance of androgen signalling within this cell-type on spermatogenesis. AR expression in VE cells of the testicular vasculature was confirmed using an antibody against AR. A Cre-inducible fluorescent reporter line was used to empirically establish the utility of a mouse line expressing Cre Recombinase driven by the Tie2-Promoter, for
CiNii 論文 - Disturbed Spermatogenesis in mice prenatally exposed to an endocrine disruptor,...
Bisphenol A (BPA), which has previously been shown to have estrogenic activity, was examined for its effect on spermatogenesis in offspring of mice that had been exposed to BPA during gestation. BPA (0, 1, 10, or 100 mg/kg body weight) was orally administered to pregnant mice from the 10th to the 17th day of gestation, and testes of 60- and 120-day-old male offspring were removed and processed for histological analysis. The results demonstrate that prenatal exposure to BPA brings about histopathological changes in the seminiferous epithelium of testes in mouse offspring, such as loss of the luminal space of the seminiferous tubules, accumulation of amorphous material in the tubes, reduction in the number of maturating elongate spermatids, and an aberrant distribution of spermatogenic cells within the epithelium. Electron microscopy suggested that disturbed spermiogenesis is one of the reasons for the reduction in the number of elongate spermatids, and that degeneration of somatic Sertoli cells ...
Effects of testosterone on spermatogenesis and luteinizing hormone release in Japanese quail - Fingerprint - Northwestern...
Dive into the research topics of Effects of testosterone on spermatogenesis and luteinizing hormone release in Japanese quail. Together they form a unique fingerprint. ...
Preparation of enriched mouse syncitia-free pachytene spermatocyte cell suspensions. - Semantic Scholar
Spermatogenesis comprises a complex succession of steps of mitosis, meiosis, and differentiation, starting with the commitment of diploid spermatogonial stem cells to differentiate and ending with the formation of haploid spermatozoa. Rodent models have been routinely used to study germ cell development and reproductive toxicology, since they present many similarities with their human counterpart while offering the advantage of recapitulating within a few weeks a process that normally takes years to occur. This article describes a method to isolate subpopulations of adult germ cells, more specifically pachytene spermatocytes, using two successive gradients, without using an elutriation centrifuge, a specialized device not available in many laboratories. Moreover, the method was designed to isolate enriched pachytene spermatocytes preparations devoid of contaminating syncitia, often formed in response to toxicants or environmental insults.
No kidding! Noisy streets can cause male infertility - Rediff.com Get Ahead
If this trend continues, humans in the future will not be able to have normal pregnancy and childbirth. | No kidding! Noisy streets can cause male infertility
Male reproductive biology of the southeastern crowned snake (Tantilla coronata) » Brill Online
The spermatogenic cycle of Tantilla coronata is post-nuptial. Spermatogenesis begins in May and reaches a peak in July and August. The sexual segment of the kidney has a cycle opposite that of the testis. Hypertrophy of the sexual segment occurs in the early spring (May) and summer july-September). Mating occurs during the period of sexual segment hypertrophy. The youngest males examined (approximately 1 2 months of age) begin spermatogenesis at the same time of year as adults, and the course of spermatogenesis appears similar to adults. It appears, however, that insufficient sperm are produced to permit successful mating following the first spermatogenic season. During the second spermatogenic season, enough sperm are produced to permit mating in the summer or following spring.
Research Festival | Intramural Research Program | National Institutes of Health
PDE8B, a cAMP-specific PDE, is highly expressed in testis.Genetic aberrations in cAMP-signaling predispose to endocrine tumors and fertility. Testes isolated from wild-type(WT) and Pde8b-/-(knock-out(KO)) mice at 6,9, and 12months(n=3-8/group).Pde8b-/- testis revealed regressive changes in seminiferous tubules(ST),containing increased atrophied tubules, 12 months (WT:0±0.001%vs.KO:11±0.012%),ST diameter significantly decreased(WT: 209.3±6.65um vs. KO: 169.6±4.22um). Atrophied tubules resembled Sertoli-cell only(SCO) syndrome. Sox9-immunostaining: significantly higher numbers of Sertoli cells(SC) in Pde8b-/-testes(KO:27.68±0.15vs.WT:19.20±0.05_Sox9+cells/tubule);SC in Pde8b-/- testes are maintained in immature state.Since spermatogonial differentiation/accumulation of spermatogonia in ST has been shown to induce germ cell death, hypothesized that germ-cell loss resulted from increased apoptosis due to accumulation of spermatogonia undergoing defective spermatogenesis.TUNEL to assess cell ...
Spermatogonium - Biology-Online Dictionary
Supplement In the early stages of spermatogenesis, the undifferentiated male germ cells (spermatogonia) divide mitotically and give rise to new spermatogonia. Some of the spermatogonia carry on the next stages to become spermatocytes, which in turn differentiate into mature sperm cells. In humans, the spermatogonia are found in the basal compartment of seminiferous tubules of the male reproductive system. ...
Annual Meetings and Symposia of the American Society of Andrology 1978-85 :: American Society of Andrology
THE EFFECT OF TESLAC IN THE TREATMENT OF IDIOPATHIC OLIGOSPERMIA Robert A. Vigersky, M.D. While a review of the treatment of idiopathic oligospermia is beyond the scope of this part of the syllabus, it is obvious from perusal of the recent literature that there is no reliable therapeutic modality available to the clinician to treat patients with this disorder. Most of the recent literature has focused on treatment approaches that raise the level of LH and FSH. While it is well known that the gonadotropins are important for spermatogenesis, other hormonal factors are also crucial. The ability of estrogens to modulate spermatogenesis has not been fully investigated in either animals or man. Several pieces of evidence suggest that estradiol (E~) may play a regulatory role in spermatogenesis. E~ inhibits spermatogenesis directly in the rat (1). It indirectly inhibits spermatogenesis by preventing the Leydig cell from maximally producing testosterone in response to a given amount of LH (2). ...
Transcriptional regulatory networks in spermatogonial stem cells - Brian Hermann
Spermatogonial stem cells (SSCs) are at the foundation of mammalian spermatogenesis, maintaining sperm production throughout adult life. The molecular mechanism...
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids |...
To date, IP6K1 is the only inositol polyphosphate metabolic enzyme shown to participate in mammalian gametogenesis. Another Ip6k1 mutant mouse strain generated by gene trapping technology introduced a retroviral insertion between exons 2 and 3 (coding exons 1 and 2), resulting in the loss of Ip6k1 transcript (http://www.informatics.jax.org/allele/key/36801). Preliminary histological analysis of these male mice revealed bilateral epididymal azoospermia and testicular degeneration, suggesting that they would display male sterility, similar to what we observe upon deletion of the terminal exon 6. Deletion of the other IP6K isoforms, IP6K2 and IP6K3, has no effect on spermatogenesis (Morrison et al., 2009; Fu et al., 2015; Moritoh et al., 2016), indicating that the different IP6K isoforms have non-overlapping functions in mammalian reproductive physiology. Treatment of mice with the pan-IP6K inhibitor TNP was shown to have no effect on male fertility, which was attributed to the inability of this ...
Long-Term Effects of Irradiation Before Adulthood: DISCUSSION(4) - Canadian Medicine
Intriguingly, effects of irradiation on the morphology of Sertoli cells were found in eight monkeys. Possibly, irradiation at the time these cells were not yet terminally differentiated and still proliferating, and/or the abnormal hormone levels induced by the disappearance of most of the germ cells, altered some of the Sertoli cells. The appearance of these aberrant cells was hyperplastic-like, but no evidence for tumor formation was seen.. In rodent studies, no effects of irradiation on tubular width and Sertoli cell morphology have been reported. Unlike in the LBNF1 rat, no arrest of spermatogenesis was seen in the monkey, because the repopulated tubules generally showed full spermatogenesis. However, the present study was carried out at a very long time after irradiation, and a transient disturbance in spermatogenesis at an earlier interval after irradiation may have taken place.. The nonaffected concentrations of testosterone indicate that Leydig cell function in the monkeys was not ...
Testis-expressed sequence 12 protein elisa and antibody
Shop Testis-expressed sequence 12 protein ELISA Kit, Recombinant Protein and Testis-expressed sequence 12 protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice
ER-resident proteins destined for degradation are dislocated into the cytosol by components of the ER quality control machinery for proteasomal degradation. Dislocation substrates are ubiquitylated in the cytosol by E2 ubiquitin-conjugating/E3 ligase complexes. UBE2J1 is one of the well-characterized E2 enzymes that participate in this process. However, the physiological function of Ube2j1 is poorly defined. We find that Ube2j1−/− mice have reduced viability and fail to thrive early after birth. Male Ube2j1−/− mice are sterile due to a defect in late spermatogenesis. Ultrastructural analysis shows that removal of the cytoplasm is incomplete in Ube2j1−/− elongating spermatids, compromising the release of mature elongate spermatids into the lumen of the seminiferous tubule. Our findings identify an essential function for the ubiquitin-proteasome-system in spermiogenesis and define a novel, non-redundant physiological function for the dislocation step of ER quality control ...
M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis
The formation of the sex vesicle, or XY body, during male meiosis and pairing of the sex chromosomes are thought to be essential for successful spermatogenesis. Despite its cytological discovery a century ago, the mechanism of XY body formation, particularly heterochromatinization of the sex chromos …
AUA 2019 Annual Meeting
Presentation Authors: Russell Hayden*, Anna Mielnik, Peter Schlegel, Darius Paduch, New York, NY. Introduction: Chromatin-modifying complexes (CPCs) play a critical role in epigenetic gene regulation and are thought to implement global genetic programs. Several long non-coding RNAs (lncRNAs) have been found to interact with CPCs to help guide these complexes to appropriate gene targets, the most notable examples being Xist and HOTAIR. In this study, we attempted to identify CPC associated lncRNAs that were differentially expressed among men with Sertoli Cell Only Syndrome (SCO) and men with normal spermatogenesis.. Methods: Testis biopsies were obtained during testicular sperm extraction for infertility. RNA-seq was performed on testis biopsies from 11 men with SCO and 10 with normal spermatogenesis using the Illumina HiSeq2000 platform. Reads were mapped using the STAR Aligner v2.5 against human genome hg38. Raw counts were normalized with Limma v3.6. Differentially expressed lncRNAs were then ...
Most recent papers with the keyword spermatogenesis histone variants | Read by QxMD
Histone phosphorylation is sometimes associated with mitosis and meiosis. We have recently identified a phosphorylation of the 127th threonine on TH2A (pTH2A), a germ cell-specific H2A variant, in condensed spermatids and mitotic early preimplantation embryos of mice. Here, we further report the existence of pTH2A at the centromeres in metaphase I spermatocytes and oocytes. Moreover, we identified Haspin, a known kinase for the 3rd threonine on H3, is responsible for pTH2A in vivo. In contrast to the severe meiotic defect in oocytes treated with a Haspin inhibitor, pTH2A-deficient mice, in which the 127th threonine was replaced by alanine, maintained the fertility and exhibited no obvious defect in both oocytes and spermatogenesis ...
5-HT Receptors - Effect of NF-κB and JNK Inhibitor
has been found in Jordan folk medicine to treat male infertility. a reduction in serum testosterone concentration, impaired sperm parameters, and a reduction in being pregnant guidelines. Testicular histology of treated rats demonstrated structural changes such as for example hypoplasia of germ cells, decrease in the width of germinal epithelium, arrest of spermatogenesis at spermatid stage (past due maturation arrest) and decrease in the amount of Leydig cells. Gene manifestation degrees of two SSCs markers (GFR1 and CSF1) in charge of self-renewal had been relatively counter-balanced. To conclude, whole vegetable and leaves aqueous components transformed the gene manifestation of two SSCs markers resulting in the imbalance between spermatogonia self-renewal and differentiation leading to past due maturation arrest. (L.) Weber former mate F.H. Wigg. (Compositae) have already been traditionally found in Jordan folk medication to take care of infertility. However, a recently available study has ...
Developmental expression patterns of testicular olfactory receptor genes during mouse spermatogenesis
A subset of olfactory receptors (ORs) is expressed in mammalian male germ cells. Recent studies on human and mouse sperm have suggested that calcium signaling via a testicular OR regulates sperm flagellar motility. However, it remains to be determined at what stages testicular ORs are expressed duri
IDEALS @ Illinois: Expression and function of basigin during early pregnancy and spermatogenesis
Basigin (BSG) is a multifunctional glycoprotein that plays an important role in both female and male reproduction since female knockout (KO) mice are infertile and male KO mice are sterile. The aim of the present study was to determine 1) whether BSG is required for proliferation of the uterine luminal epithelium during early pregnancy in preparation for implantation; 2) whether BSG is required for HESCs decidualization; and 3) whether BSG is essential for the interactions between gametes and Sertoli cells during spermatogenesis. BSG protein was expressed in the uterine epithelium at estrus in βERKO mice but not in αERKO mice. However, a higher level of Bsg mRNA was observed in the uteri of αERKO mice as compared with wild type (WT) and βERKO mice. In the mouse, estrogen alone induces the proliferation of both luminal and glandular epithelial cells during early pregnancy. On day 1 of pregnancy, the expression levels of ERα and a well-known estrogen responsive gene, MUC1, appeared to be ...
What is sertoli cell? - Lifeeasy Biology: Questions and Answers
Sertoli cell is associated with developing germ cells in seminiferous tubule of the testis.. These cells protect the developing sperm besides maintaining, nourishing, and regulating the process of spermatogenesis (process by which male gametes form).. Process of Spermatogenesis : diploid spermatogonium (undifferentiated male germ cell) , spermatocyte , spermatid (immature male sex cell) , mature sperm ...
Expression of h-y antigen during spermatogenesis. by G C. Koo, L R. Mittl et al.
Koo, G C.; Mittl, L R.; and Goldberg, C L., Expression of h-y antigen during spermatogenesis. (1979). Subject Strain Bibliography 1979. 717 ...
Spermatogenesis and sperm structure in some meloidogyne spp heteroderoidea meloidogynidae and a comparison with those in some...
Shepherd A.M.; Clark S.A., 1983: Spermatogenesis and sperm structure in some meloidogyne spp heteroderoidea meloidogynidae and a comparison with those in some cyst nematodes heteroderoidea heteroderidae
Publications | College of Agriculture and Veterinary Sciences
The cycle of spermatogenesis/seminiferous cycle was investigated in the goat testis using both light and electron microscopy techniques. Using the various cell associations and the accompanying changes in spermatid shape and location, the cycle was divided into eight (8) successive stages. The cycle began with the accomplishment of spermiation (stage 1) and ended with apical migration and close attachment of late maturation phase spermatids at the Sertoli cell apex accompanied by adluminal retention of residual bodies with dense staining inclusions (stage 8). The early stages of the cycle (stages 1-4) were therefore characterized by the presence of only one generation of spermatids, the second one appearing only after the division of secondary spermatocytes in stage 4. Consequently, stages 5-8 had two generations of spermatids; Golgi or cap phase as well as maturation phase spermatids. Although stages 5 to 7 appeared as distinct entities, stages 6 and 7 were rather short-lived and considered as ...
Pharos : Target Details - Q9BWX1
May play a role in spermatogenesis. Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Differentiating the Male Germ Line | Science Signaling
The TATA box-binding protein (TBP) is a conserved transcription factor that binds to the core promoter, and TBP-associated factors, or TAFs, represent one of several classes of coactivators that participate in transcription activation. The presence of varied TAFs allows for plasticity in function for transcribing specific genes. For example, several testis-specific TAFs function in regulating gene expression in Drosophila spermatogenesis. Chen et al. now find that in the male germ line, tissue-specific TAFs regulate gene expression by counteracting the repressive effect of Polycomb protein complexes to allow terminal differentiation. The testis TAFs sequester Polycomb-containing complexes to the nucleolus, which suggests that subnuclear localization functions in regulating transcription.. X. Chen, M. Hiller, Y. Sancak, M. T. Fuller, Tissue-specific TAFs counteract polycomb to turn on terminal differentiation. Science 310, 869-872 (2005). [Abstract] [Full Text]. ...
A Lack of This One Mineral Can Cause Male Infertility
Men, listen up! If you are suffering from impotence, low sperm count, or infertility, and think you have tried everything, you should pay attention. Your b
Efecto del Nogal sobre el Peso, Glucosa en la Sangre y Hormonas Sexuales de Ratas Macho Diabéticas
INTRODUCTION. Diabetes is the most common endocrine disorder characterized by hyperglycemia and Carbohydrate, fat and protein metabolism disorder (Williams & Pickup, 2004). According to the census of World Health Organization (WHO) in 2008, nearly 246 million people suffer from diabetes. It is estimated that this figure reach 380 million by 2050. About 90% of the diabetic patients have sexual dysfunctions in the form of reduction in sexual derive and fertility (Pereira et al., 2007).. Testis function is, at first, controlled by hypophysis hormones. The follicle-stimulating hormone (FSH) regulates spermatogenesis whereas; luteinizing hormone (LH) controls the performance of interstitial cells (Ward et al., 1991). FSH is a crucial factor in the development of testis, performance of sustentacular cells, and protection of normal spermatogenesis. Also, the hypophysis of diabetic rats is affected by the reduction in response along with reduction in FSH and LH levels (Seethalakshmi et al., 1987). These ...
A variant of Runx2 that differs from the bone isoform in its splicing is expressed in spermatogenic cells [PeerJ]
Background. Members of the Runx gene family encode transcription factors that bind to DNA in a sequence-specific manner. Among the three Runx proteins, Runx2 comprises 607 amino acid (aa) residues, is expressed in bone, and plays crucial roles in osteoblast differentiation and bone development. We examined whether the Runx2 gene is also expressed in testes. Methods. Murine testes from 1-, 2-, 3-, 4-, and 10-week-old male mice of the C57BL/6J strain and W∕Wv strain were used throughout the study. Northern Blot Analyses were performed using extracts form the murine testes. Sequencing of cDNA clones and 5′-rapid amplification of cDNA ends were performed to determine the full length of the transcripts, which revealed that the testicular Runx2 comprises 106 aa residues coding novel protein. Generating an antiserum using the amino-terminal 15 aa of Runx2 (Met1 to Gly15) as an antigen, immunoblot analyses were performed to detect the predicted polypeptide of 106 aa residues with the initiating Met1. With
Journal: Journal of hazardous materials / Source: 2011 v.187 no.1-3 / Text Availability: Citation in PubAg - PubAg Search...
This study was aimed to evaluate the effect on spermatogenesis of a 62kDa protein (Rp) isolated from 50% ethanolic extract of the root of Ricinus communis in mice. A dose response study in mice revealed that 25mg/kg body weight/day was the most effective dose. Swiss strain mature male mice of 30 days old were divided into two group namely control and Rp treated (25mg/kg body weight/day). The study ...
Cell proliferation, tumorogenicity, and apoptosis sub-cluster 2
Lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid], a well-known antispermatogenic drug, was studied for the first time in pubertal mice to assess its possible effects on spermatogenesis. Male CD1 mice were orally treated on Postnatal Day (PND) 28 with a single dose of LND (100 mg/kg body weight) and sacrificed on PND30, PND42 ...
Nonsteroidal Gonadal Factors - Physiological Roles and Possibilities in Contraceptive Development | Oxfam GB | Oxfams Online...
Buy Nonsteroidal Gonadal Factors - Physiological Roles and Possibilities in Contraceptive Development, Oxfam, Hodgen, Gary; Rosenwaks, Zev; Spieler, Jeffrey, Books, Health Family Lifestyle
RFA-HD-06-014: Contraceptive Development Research Centers Program (U54)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Contraceptive Development Research Centers Program (U54) RFA-HD-06-014. NICHD
Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Ontogenetic testicular development and spermatogenesis in rays: the Cownose Ray, Rhinoptera bonasus, as a model | SpringerLink
An understanding of testicular anatomy, development, and seasonality has implications for studies of morphology, behavior, physiology, and bioenergetics of males. Ontogenetic testicular development an
NSL3 could also have important endocrine or paracrine roles in other tissues. Although defective spermatogenesis found in INSL3 or LGR8 null mice could be the secondary effects of cryptorchidism, Leydig cell-derived INSL3 could play a paracrine role in the testis because LGR8 is also expressed in the testis. In females, INSL3 is expressed in the luteal cells of the ovary through the estrous cycle and during pregnancy  ...
DAZL - Wikipedia
Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene. The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. DAZL has been shown to interact with DAZ1. GRCh38: Ensembl release 89: ENSG00000092345 - Ensembl, May 2017 Human PubMed Reference:. Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, ...
The Natural History of Endocrine Function and Spermatogenesis in Klinefelter Syndrome: What the Data Show - Fertility Sterility...
Efforts are underway to try and increase identification of Klinefelter males as soon as possible to allow intervention at an earlier stage, although it is unknown if that will necessarily change the course of the disorder. While this may certainly turn out to be important for the learning difficulties that are part of the Klinefelter phenotype, it is unclear at this time whether early therapeutic involvement in terms of androgen replacement or fertility is helpful or hurtful to the individual. This contribution will briefly summarize what is understood about testicular function and anatomy as regards both the androgenic and spermatogenic compartments.. ...
mice to man
Surrogate Fathers New Scientist 31 Jan 98. ONE of the worlds leading reproductive biologists has applied for funding to transplant cells from human testes into those of mice. The aim is to create mice that produce human sperm. The first time you say to anyone that we want to produce human sperm in mice, they look at you with frank horror, says Roger Short of the Royal Womens Hospital in Melbourne. But once people overcome their initial gut reaction, he claims, many accept the proposal. Developments in IVF now mean that many women with fertility problems can conceive. But men who produce little or no sperm have scant hope of becoming fathers. In many cases, says Short, the cause may be a mutation in one of the genes on the Y chromosome that control spermatogenesis-the producfion of sperm from germ cells, which are known as spermatogonial stem cells. Being able to study human spermatogenesis in a laboratory animal may help researchers to work out why the process fails in many infertile men. ...
The long-term maintenance of sperm production in mammals
A research team led by Professor and Janeway Distinguished Chair Robert Braun, Ph.D., and Associate Research Scientist Manju Sharma, Ph.D., found a rare subpopulation of spermatogonial cells expressing a specific protein, EOMES, that appear to represent the elusive long-lived spermatogonial stem cells that support continued spermatogenesis.
"Spermatogenesis". Spermatogenesis. Retrieved 12 January 2022. Harrison, RG; Weiner, JS (1949). "Vascular patterns of the ... Spermatogenesis - male reproductive physiology Spermatogenesis animation (Articles with short description, Short description is ... Prolactin also appears to be important for spermatogenesis. Disorders of spermatogenesis may cause oligospermia, which is semen ... Exposure to pesticides also affects spermatogenesis. Hormonal control of spermatogenesis varies among species. In humans the ...
... is known as the interruption of germinal cells of specific cellular type, which elicits an altered ... It is known that spermatogenesis is under the control of androgens, but germ cells (that will become gametes), do not express a ... Spermatogenesis is controlled by androgens, namely testosterone and follicle-stimulating hormone (FSH), these are the most ... This hormone is the main androgenic steroid in the process of spermatogenesis and is regulated by a hormone known as ...
Spermatogenesis associated 13
... is a protein that in humans is encoded by the SPATA13 gene. GRCm38: Ensembl release 89: ... "Entrez Gene: Spermatogenesis associated 13". Retrieved 2018-04-26. Kawasaki Y, Sagara M, Shibata Y, Shirouzu M, Yokoyama S, ...
In vitro spermatogenesis
Song, Hye-Won; Wilkinson, Miles F. (2012-10-01). "In vitro spermatogenesis". Spermatogenesis. 2 (4): 238-244. doi:10.4161/spmg. ... Finally, in vitro spermatogenesis using animal or human cells can be used to assess the effects and toxicity of drugs before in ... In vitro spermatogenesis is the process of creating male gametes (spermatozoa) outside of the body in a culture system. The ... While rodent spermatogenesis is not identical to its human counterpart, especially due to the high evolution rate of the male ...
Gilbert SF (2000). "Spermatogenesis". Developmental Biology (6th ed.). Gilbert SF (2000). "Oogenesis". Developmental Biology ( ...
Immortalised cell line
Kaur G, Dufour JM (January 2012). "Cell lines: Valuable tools or useless artifacts". Spermatogenesis. 2 (1): 1-5. doi:10.4161/ ...
Spermatogenesis in testes is a process in which spermatogonia differentiates into spermatocytes through mitosis and meiosis, ... Fish can present cystic or semi-cystic spermatogenesis[definition needed] in relation to the release phase of germ cells in ... During spermiogenesis, the last stage of spermatogenesis, the haploid spermatids develop into spermatozoa. In the ovaries, ... Nishimura, Hitoshi; L'Hernault, Steven W. (25 September 2017). "Spermatogenesis". Current Biology. 27 (18): R988-R994. doi: ...
... complex proteins during spermatogenesis". Spermatogenesis. 5 (1): e979061. doi:10.4161/21565562.2014.979061. PMC 4581071. PMID ...
... is the final stage of spermatogenesis, during which the spermatids develop into mature spermatozoa. At the ... Spermatogenesis. 1 (1): 14-35. doi:10.4161/spmg.1.1.14525. PMC 3158646. PMID 21866274. Fraser, L. R. (September 1998). " ...
In spermatogenesis, the fusome partitioning is symmetric and the fusome is still present during the meiotic divisions. 1.2 ... Fuller, M.T. (1993). Spermatogenesis. In The Development of Drosophila, M. Bate and A. Martinez-Arias, eds. (Cold Spring Harbor ...
Spermatogenesis. Methods in Molecular Biology. Vol. 927. pp. 77-87. doi:10.1007/978-1-62703-038-0_8. ISBN 978-1-62703-037-3. ...
... complex proteins during spermatogenesis". Spermatogenesis. 5 (1): e979061. doi:10.4161/21565562.2014.979061. PMC 4581071. PMID ... Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. ...
"Comparative testicular structure and spermatogenesis in bony fishes". Spermatogenesis. e983400 (3): e983400. doi:10.4161/ ...
... whereas in other stages of spermatogenesis the reciprocal exchange type of HRR is more frequent. During mouse spermatogenesis, ... The spermatogenesis process has been elucidated throughout the years by researchers who divided the process into multiple ... The spermatogenesis process in mammals as a whole, involving cellular transformation, mitosis, and meiosis, has been well ... The release of FSH into the testes will enhance spermatogenesis and lead to the development of Sertoli cells, which act as ...
Spermatogenesis. Methods in Molecular Biology (Clifton, N.J.). Vol. 927. pp. 519-529. doi:10.1007/978-1-62703-038-0_44. ISBN ...
Therefore, once spermatogenesis has begun, no more Sertoli cells are created, and their population within the seminiferous ... Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis ... Because its main function is to nourish developing sperm cells through the stages of spermatogenesis, the Sertoli cell has also ... Anamnionts (fish and amphibians) employ cystic spermatogenesis in order to produce sperm cells. In the Amniota, Sertoli cells ...
Vangompel MJ, Xu EY (Jan 2011). "The roles of the DAZ family in spermatogenesis: More than just translation?". Spermatogenesis ... "Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis". Fertility and Sterility. 83 (2): 513-5. ...
... complex proteins during spermatogenesis". Spermatogenesis. 5 (1): e979061. doi:10.4161/21565562.2014.979061. PMC 4581071. PMID ...
DAZ protein family
DAZ is not absolutely required for spermatogenesis as some DAZ deleted men are still able to father children. DAZ pushes ESCs ... BOULE and DAZL are important for both oogenesis and spermatogenesis. BOULE and DAZL are both located on autosomes as single ... One DAZ homologue is expressed in nearly every stage of spermatogenesis, from Primordial Germ Cells (PGCs) to mature ... Vangompel MJ, Xu EY (January 2011). "The roles of the DAZ family in spermatogenesis: More than just translation?". ...
They found that Taf7l has dual functionality during spermatogenesis. In early stage spermatocytes, for example in primary ... TAF7l localizes in a different compartment relative to TBP during early spermatogenesis, implying a TBP-independent function ... Proteomics of Spermatogenesis. Springer Science & Business Media. p. 327. ISBN 9780387276557. GRCh38: Ensembl release 89: ...
It may detect signs of testicular dysgenesis, which is often related to an impaired spermatogenesis and to a higher risk of ... Cheng, C. Yan; Wong, Elissa W.P.; Yan, Helen H.N.; Mruk, Dolores D. (February 2010). "Regulation of spermatogenesis in the ... These deletions affect protein production that is vital for spermatogenesis. Studies have shown that this is an inherited trait ... A 1 degree increase in temperature will reduce 14% of spermatogenesis. Researchers in Calcutta conducted a study between 1981 ...
Fice HE, Robaire B (July 2019). "Telomere Dynamics Throughout Spermatogenesis". Genes. 10 (7): 525. doi:10.3390/genes10070525. ...
27 (93): 147-9. Painter T.S. (1922). "The spermatogenesis of man". Anat. Res. 23: 129. Painter T.S. (1923). "Studies in ... mammalian spermatogenesis II". J. Exp. Zoology. 37 (3): 291-336. doi:10.1002/jez.1400370303. Wright, Pearce (11 December 2001 ...
The Spermatogenesis of Batrachoseps. Polymorphous spermatogonia, auxocytes, and spermatocytes. Journal of Morphology. DOI: ...
C.Y. Cheng (24 October 2009). Molecular Mechanisms in Spermatogenesis. Springer Science & Business Media. pp. 259-. ISBN 978-0- ...
Painter, Theophilus S. (April 1923). "Studies in mammalian spermatogenesis. II. The spermatogenesis of man". Journal of ... Painter T.S. "The spermatogenesis of man" p. 129 in "Abstracts". The Anatomical Record. 23 (1): 89-132. January 1922. doi: ... von Winiwarter H (1912). "Études sur la spermatogenese humaine" [Human spermatogenesis studies]. Arch. Biologie (in French). 27 ...
Washington NL, Ward S (June 2006). "FER-1 regulates Ca2+ -mediated membrane fusion during C. elegans spermatogenesis". Journal ... Riddle DL, Blumenthal T, Meyer BJ, Priess JR (1997). Organelle Morphogenesis During Spermatogenesis. Cold Spring Harbor ... factor involved in fusion of vesicles called membraneous organelles with the sperm plasma membrane during spermatogenesis in C ...
Spermatogenesis continues after birth. In the third to fifth months of life, some of the fetal spermatogonia residing along the ... Spermatogenesis arrests at this stage until puberty. Most normal-appearing undescended testes are also normal by microscopic ... The inhibition of spermatogenesis by ordinary intra-abdominal temperature is so potent that continual suspension of normal ... At least one contributing mechanism for reduced spermatogenesis in cryptorchid testes is temperature. The temperature of testes ...
Spermatogenesis is enhanced at temperatures slightly less than core body temperature. The spermatogenesis is less efficient at ... In all cases, the loss in testes volume corresponds with a loss of spermatogenesis. The testicles of calves, lambs, roosters, ... The testes grow in response to the start of spermatogenesis. Size depends on lytic function, sperm production (amount of ... The classic hypothesis is that cooler temperature of the testes allows for more efficient fertile spermatogenesis. There are no ...
Higher temperatures affect spermatogenesis. Temperature control is accomplished by the smooth muscles of the scrotum moving the ...
Nanoparticles and Spermatogenesis
This review examines the effects of nanoparticles on spermatogenesis at the clinical, cellular and molecular levels. ... Nanoparticles and Spermatogenesis: How do Nanoparticles Affect Spermatogenesis and Penetrate the Blood-testis Barrier. ... How do nanoparticles affect spermatogenesis? *. Although the toxicological data of how nanoparticles (NPs) affect ... Although spermatogenesis is a very important process for male fertility, the acrosome, equator region and midpiece, which are ...
Defective Spermatogenesis: Martin et al. Respond
Spermatogenesis - Male reproductive physiology | health.am
Spermatogenesis. The spermatogonia, the primitive germ cells next to the basal lamina of the seminiferous tubules, mature into ... During spermatogenesis, cohorts of germ cells at the same point in development are linked by cytoplasmic bridges and pass ... Spermatogenesis is a complex process by which primitive, totipotent stem cells divide to either renew themselves or produce ... Several cycles of spermatogenesis coexist within the germinal epithelium at any one time. The duration of an entire ...
Male Reproductive System | Spermatogenesis | Pearson+ Channels
SPATA21 (spermatogenesis associated 21)
Androgens and spermatogenesis - PubMed
In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular ... Androgens and spermatogenesis Sophie Christin-Maitre et al. Ann Endocrinol (Paris). 2022 Jun. ... In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular ... Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice. Singh J ...
QUT - Male chlamydia infections: the key role of macrophages in testicular dissemination and disrupted spermatogenesis
The key cell types (Macrophages, Leydig, Sertoli and Germ cells) each play a specific role in regulating spermatogenesis ( ... Male chlamydia infections: the key role of macrophages in testicular dissemination and disrupted spermatogenesis. ... Male chlamydia infections: the key role of macrophages in testicular dissemination and disrupted spermatogenesis ... and significantly disrupt spermatogenesis. This has profound effects on male fertility, including reduced sperm motility and ...
Sohlh1 - Spermatogenesis and oogenesis-specific basic helix-loop-helix 1 - Rattus norvegicus (Rat) - Sohlh1 gene & protein
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1. MOUSE ... spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1. MUSCR ... Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1. MICOH ... tr,D4A4L1,D4A4L1_RAT Spermatogenesis and oogenesis-specific basic helix-loop-helix 1 OS=Rattus norvegicus OX=10116 GN=Sohlh1 PE ...
Cancer - ALTE16C1: Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult...
Fluoride Action Network | Exposure to high fluoride concentration in drinking water will affect spermatogenesis and...
Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats. ... These changes along with lower protein levels affected spermatogenesis. Steroidogenesis was also altered since the ... were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats ...
Research Brief 63: Stage-specific Actions of Cadmium During Spermatogenesis (Superfund Research Program)
Spermatogenesis also involves several cell types found only in the testis, such as the Sertoli cell, which produces a number of ... Spermatogenesis is an essential part of human reproduction. This dynamic process produces millions of sperm per day in a ... In the spiny dogfish shark spermatogenesis occurs in enclosed follicle-like structures called spermatocysts, which are not only ... However, the complexity of spermatogenesis makes it a difficult process to study cause-effect relationships. Many individual ...
Spermatogenesis and Spermatozoa in Stygocapitella subterranea (Annelida, Parergodrilidae), an Enigmatic Supralittoral...
Spermatogenesis conforms to the general pattern typical of Annelida. Spermatids develop on large cytophores comprising at least ... An ultrastructural study of the spermatogenesis and spermatozoa was undertaken to elucidate whether these similarities might ... An ultrastructural study of the spermatogenesis and spermatozoa of Stygocapitella subterranea was undertaken to elucidate ... Spermatogenesis, spermatozoa, seminal receptacles and the transformations of sperm after mating were examined for the first ...
Serotonin reuptake inhibitor citalopram inhibits gnrh synthesis and spermatogenesis in the male zebrafish<...
Prasad, P., Ogawa, S., & Parhar, I. (2015). Serotonin reuptake inhibitor citalopram inhibits gnrh synthesis and spermatogenesis ... Prasad, P, Ogawa, S & Parhar, I 2015, Serotonin reuptake inhibitor citalopram inhibits gnrh synthesis and spermatogenesis in ... Serotonin reuptake inhibitor citalopram inhibits gnrh synthesis and spermatogenesis in the male zebrafish. In: Biology of ... Serotonin reuptake inhibitor citalopram inhibits gnrh synthesis and spermatogenesis in the male zebrafish. / Prasad, Parvathy; ...
Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to...
Spermatogenesis is a complex process where spermatogonia develop into haploid, mobile sperm cells. The genes guiding this ... In species with XY sex chromosomes, the outcome of this trade-off is found to vary across the stages of spermatogenesis but ... Here we characterize avian spermatogenesis at single cell resolution from testis of collared and pied flycatchers. We find ... We conclude that the high throughput of bird spermatogenesis, at least partly, is explained by relaxed developmental constraint ...
Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin...
Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin ... Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin ... Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin ...
Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut-testis axis | Gut
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes. Gut 2020;69:1608-19. ... The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids. Cell Rep 2018;25:1650-67 ... Role of retinoid signaling in the regulation of spermatogenesis. Cytogenet Genome Res 2004;105:189-202.doi:10.1159/000078189 ... Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut-testis axis ...
NRF1 coordinates with DNA methylation to regulate spermatogenesis - PubMed
Spermatogenesis is a highly coordinated process that requires tightly regulated gene expression programmed by transcription ... NRF1 coordinates with DNA methylation to regulate spermatogenesis Junpeng Wang 1 , Chao Tang 1 , Qian Wang 1 , Jun Su 1 , Ting ... NRF1 coordinates with DNA methylation to regulate spermatogenesis Junpeng Wang et al. FASEB J. 2017 Nov. ... YY1 and CP2c in Unidirectional Spermatogenesis and Stemness. Cheon YP, Choi D, Lee SH, Kim CG. Cheon YP, et al. Dev Reprod. ...
NANOS3 suppresses premature spermatogonial differentiation to expand progenitors and fine-tunes spermatogenesis in mice |...
5E,F). The timing of each step of spermatogenesis is fixed and precisely regulated (França et al., 1998; Gewiss et al., 2019; ... NANOS3 suppresses premature spermatogonial differentiation to expand progenitors and fine-tunes spermatogenesis in mice Hiroki ... To eliminate Nanos3-Rfp during spermatogenesis, we used Nanos3-Cre mice (Suzuki et al., 2008). Although NANOS3 is expressed in ... Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium ...
About Spermatogenesis Spermatogenesis produces mature male gametes, commonly called sperm but specifically known as spermatozoa ... The process of spermatogenesis. Spermatogenesis begins with mitosis of the diploid spermatogonia (Pic.2). Because these cells ... Hormonal control of spermatogenesis. In humans the mechanism is not completely understood; however it isknown that initiation ... The spermatogenesis occurs in the seminiferous tubules that form the bulk of each testis (Pic.1 ).The process begins at puberty ...
Spermatogenesis | Colorado PROFILES
"Spermatogenesis" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Spermatogenesis" by people in this website by year, and ... Below are the most recent publications written about "Spermatogenesis" by people in Profiles. ... A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. ...
Meiosis and spermatogenesis - Zoomable
Luteinizing Hormone Deficiency: Practice Essentials, Background, Causes
Understanding spermatogenesis is a prerequisite for treatment | Reproductive Biology and Endocrinology | Full Text
The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the ... The profound knowledge of the complicate process of spermatogenesis and all cells or cell systems involved with is the ... Identification of the border line between normal and disturbed spermatogenesis substantiate the diagnosis of impaired male ... intratesticular and extratesticular regulation of spermatogenesis. Normal germ cells must be discriminated from malformed, ...
Percutaneous epididymal sperm aspiration: a diagnostic tool for the prediction of complete spermatogenesis.
NEK1 facilitates cohesin removal during mammalian spermatogenesis - Fingerprint - Albert Einstein College of Medicine
PENGARUH PEMBERIAN MADU TERHADAP STAGING SPERMATOGENESIS DAN SEL LEYDIG PADA MENCIT (Mus musculus) YANG DIINFEKSI Toxoplasma...
Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the...
Spermatogenesis. Testis. Rats. RESUMO OBJETIVO:Determinar se a torção testicular causa efeitos tardios sobre a espermatogênese ... CONCLUSIONS: Testicular torsion does not cause long-term effects on the spermatogenesis of the contralateral testis in pubertal ... using specific spermatogenesis parameters to elucidate the conflicting results in the literature. METHODS: Seventy-four ... To determine whether the testicular torsion causes long-term effects on the spermatogenesis of the contralateral testis, and ...
Reproduction - Spermatogenesis | CU Experts | CU Boulder
SpermTestisFertilityImpairment of spermatogenesisTestosteroneImpact on spermatogenesisMammalian spermatogenesisRatsMaturation of spermatozoaLeydigArrestAndrogenTesticularChromosomePolarityOogenesisSpermatidsOccursSertoliProteinsSpermatogenicSeverelyAlterationsMaleVivoProcessHormoneHumansEffectsPeer-reviewedRolesDefineSearchVitaminDescribeFunctionCellsLevels
- The position of the testes or scrotum is crucial because spermatogenesis requires a lower temperature than the normal body temperature of 37 °C (98.6 °F) in order to obtain viable sperm cells. (vedantu.com)
- Any drug that does harm to the spermatogonia, Sertoli cells or Leydig cells can influence the processes of spermatogenesis and sperm maturation. (oncotarget.com)
- Drugs that induce deleterious changes to the microenvironment of the testes or epididymis may also affect spermatogenesis and sperm maturation, leading to adverse effects on fertility. (oncotarget.com)
- A unique type of meiosis forms sperm (spermatogenesis) and egg cells (oogenesis), respectively. (thenextgalaxy.com)
- The purpose of spermatogenesis to convert the diploid cells into four haploid sperm cells. (thenextgalaxy.com)
- Research into spermatogenesis and sperm biology seeks to better understand factors influencing and controlling male fertility and infertility. (tamu.edu)
- Faculty in Veterinary Physiology and Pharmacology investigate genetic, epigenetic, and environmental influences on spermatogenesis and sperm biology, and the long-term effects on pregnancy and the developing offspring of paternal preconception exposures mediated through the sperm. (tamu.edu)
- This androgen-binding protein causes high local concentrations of testosterone near the sperm, an essential factor in the development of normal spermatogenesis. (medscape.com)
- Treatment with M. pruriens significantly inhibited lipid peroxidation, elevated spermatogenesis, and improved sperm motility. (nih.gov)
- Count of different generations of sperm cells at middle stage i.e. stage VII of the cycle of spermatogenesis along with programmed cell death by genomic analysis were observed. (ijfans.org)
- Results: Dose of ethyl acetate fraction (5 mg/ 100 g body weight) focused significant negative deviation in spermatogenesis, androgenesis and decreased germ cells numbers at different generations with decreased seminiferous tubular diameter along with increased numbers of programmed death of sperm cells in Wistar strain male rats. (ijfans.org)
- Effect of high altitude exposure on spermatogenesis and epididymal sperm count in male rats. (bvsalud.org)
- Advantages you can expect are a strong and long-lasting erection during the whole sex, stronger libido and increased desire for intercourse, increased amount of testosterone produced, stimulation of spermatogenesis, better sperm activity and sperm quality! (activemodepotency.com)
- Tobacco constituents can have a negative impact on the endocrine system, affecting therefore ovulation in the case of women and spermatogenesis in the case of men, giving therefore rise to poor-quality eggs and sperm. (invitra.com)
- We aim to uncover the direct evidence involving the gut-testis axis in the aetiology of impaired spermatogenesis. (bmj.com)
- This in turn provides a unique mechanism to modulate junction remodeling in the testis to support germ cell transport across the epithelium in particular the BTB during the epithelial cycle of spermatogenesis. (popcouncil.org)
- These contrasting data with G-AR-/y mice suggest AR might have different roles in the various cells within testis to contribute to normal spermatogenesis and male fertility in mice. (elsevier.com)
- Importin α genes have distinct expression patterns in mouse testis, implying they may have unique roles during mammalian spermatogenesis. (mdc-berlin.de)
- Bojer on testosterone biosynthesis in testis and spermatogenesis in Wistar rats. (semanticscholar.org)
- It is considered a common cause for infertility as it elevates the temperature of the testis and this disturbs spermatogenesis and decreases its volume [7,8]. (who.int)
- The heart of much of the testis is severely impaired spermatogenesis is more often found other concomitant sexual discontinuations because of its effect on dapox- as a culturally specific pattern of urinary extravasation is not a feminising genitoplasty, in situ. (gatech.edu)
- At this workshop, experts in testis physiology, toxicology, and tissue engineering discussed approaches for creating improved in vitro environments that would be more conducive to maintaining spermatogenesis and steroidogenesis and could provide more predictive models for testicular toxicity testing. (ainhibitor.com)
- We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. (oncotarget.com)
- Together, these data provide in vivo evidence showing male mice without AR in germ cells can still have normal spermatogenesis and fertility, suggesting the essential roles of AR during spermatogenesis might come from indirect cell- cell communication in a paracrine fashion. (elsevier.com)
- We then compared the consequences of AR loss in the spermatogenesis and fertility of G-AR-/y mice with two other testicular cell-specific AR-/y mice and total AR knockout male mice. (elsevier.com)
- IMSEAR at SEARO: Effect of some steroids on spermatogenesis & fertility of rats. (who.int)
- Here we use a loss-of-function approach to specifically determine the role of importin α7 in spermatogenesis and male fertility. (mdc-berlin.de)
- Our work uncovers the essential role of importin α7 in spermatogenesis and hence in male fertility. (mdc-berlin.de)
- The p53 family of transcription factors, including p53, p63, and p73, are critical for many physiological processes, including female fertility, but little is known about their functions in spermatogenesis. (uni-konstanz.de)
- The results show that in P mice C. longa treatment causes reversible suppression of spermatogenesis and fertility, thereby suggesting the potential of this plant in the regulation of male fertility. (contraceptionjournal.org)
- News about the potential impact of COVID-19 on spermatogenesis and findings related to pregnancy in patients with breast cancer helped make fertility this week's top trending clinical topic. (medscape.com)
- From encouraging news about pregnancy among patients with breast cancer to worrisome findings regarding spermatogenesis in men with COVID-19, fertility was a subject of much interest and became this week's top trending clinical topic. (medscape.com)
- Spermatogenesis and male fertility are dependent on FSH, LH, and high levels of testosterone within the testicles. (limelight.moe)
-  As such, bicalutamide and other NSAAs may uniquely have the potential to preserve testicular function and spermatogenesis and thus male fertility relative to alternative therapies. (limelight.moe)
Impairment of spermatogenesis2
- Thus, TBT had significantly retarded the reproductive activity and substantially reduced the biochemical constituents ultimately led to impairment of spermatogenesis in the mud crab S. serrata. (tubitak.gov.tr)
- Here, we report that deficiency of the TAp73 isoform, but not p53 or ΔNp73, results in male infertility because of severe impairment of spermatogenesis. (uni-konstanz.de)
-  This is particularly so considering that bicalutamide increases circulating testosterone levels, and by extension gonadal testosterone production, by up to two-fold in males,  and that only a small fraction of normal intratesticular testosterone levels, and by extension androgen action, appears to be necessary to maintain spermatogenesis. (limelight.moe)
- Treatment of an infertile man with testosterone does [not] improve spermatogenesis, since exogenous administrated testosterone and its metabolite estrogen will suppress both GnRH production by the hypothalamus and luteinizing hormone production by the pituitary gland and subsequently suppress testicular testosterone production. (limelight.moe)
- Suppression of testosterone production by the leydig cells will result in a deficient spermatogenesis, as can be seen in men taking anabolic-androgenic steroids. (limelight.moe)
- However, for this to fructify, it requires the use of testosterone antagonist to nullify the negative feedback effect of circulating testosterone on the release of FSH and LH, thus augmenting the secretion of testosterone and spermatogenesis. (limelight.moe)
Impact on spermatogenesis2
- Bioaccumulation of tributyltin and its impact on spermatogenesis in mu" by REVATHI PERANANDAM, IYAPPARAJ PALANISAMY et al. (tubitak.gov.tr)
- Recent studies show that gut microbiota can have an impact on spermatogenesis. (bmj.com)
- Mammalian spermatogenesis is a complex developmental process. (elsevier.com)
- This Study aimed to investigate the efficiency of aqueous extraction of Alhagi maurorum leaves against oxidative stress induced by Carbon tetrachloride (CCl 4 ) on spermatogenesis and the level of glutathione, superoxide dismutase, malondialdehyde in adult rats. (vetmedmosul.com)
Maturation of spermatozoa1
- The process of spermatogenesis, which is responsible for the formation and maturation of spermatozoa, is violated. (activemodepotency.com)
- It was found that 13-cis-retinoic acid induced almost complete cessation of spermatogenesis and produced alterations in the cytoplasm of Leydig cells. (who.int)
- The results provide clear in vivo evidence that androgen/AR signaling in Sertoli cells plays a direct important role in spermatogenesis and in Leydig cells plays an autocrine regulatory role to modulate Leydig cell steroidogenic function. (elsevier.com)
- We previously described the autosomal recessive mouse morc(TgN(Tyr)1Az) (microrchidia) mutation, a serendipitous transgenic insertional mutation which causes arrest of spermatogenesis prior to the pachytene stage of meiosis prophase I. We now report the molecular characterization of the morc locus and positional cloning of a gene disrupted by the morc(TgN(Tyr)1AZ) mutation. (elsevier.com)
- Using a Cre-Lox conditional knockout strategy, we generated a germ cell-specific androgen receptor (AR) knockout mouse (GAR-/y) with normal spermatogenesis. (elsevier.com)
- Notably, the abnormal metabolic effects of vitamin A were transferable to the testicular cells through the circulating blood, which contributed to abnormal spermatogenesis, as confirmed by FMT. (bmj.com)
- From the above results, it can be concluded that administration of cisplatin suppresses the spermatogenesis and steroidogenesis by inhibiting the activity levels of testicular steroidogenic marker enzymes (3? (rjptonline.org)
- This phenomenon occurs during spermatogenesis, resulting in three copies of the chromosome 21. (bvsalud.org)
- Cell polarity proteins and spermatogenesis" by Ying Gao, Xiang Xiao et al. (popcouncil.org)
- 2016. "Cell polarity proteins and spermatogenesis," Seminars in Cell & Developmental Biology 59: 62-70. (popcouncil.org)
- However, this phenomenon would cease to exist without spermatogenesis and oogenesis. (thenextgalaxy.com)
- Oogenesis is relatively similar to spermatogenesis. (thenextgalaxy.com)
- While the spermatogenesis process, spermatids tend to appear in a tail by developing microtubules under one of the centrioles, which eventually becomes the basal body. (vedantu.com)
- the affected tubules showed loosening of germinal epithelium, intraepithelial vacuolation and mixing of spermatids of different stages of spermatogenesis. (contraceptionjournal.org)
- Spermatogenesis occurs in several systems inside the male reproductive system. (vedantu.com)
- The process of spermatogenesis occurs through meiosis. (thenextgalaxy.com)
- Sertoli cells, under the influence of androgens, also secrete inhibin, a polypeptide, which may help to locally regulate spermatogenesis. (medscape.com)
- Spermatogenesis is driven by an ordered series of events, which rely on trafficking of specific proteins between nucleus and cytoplasm. (mdc-berlin.de)
- There are various causes of suppressed spermatogenesis or spermatogenic failure, including genetic defects [ 2 , 3 ], but acquired factors also play an important role. (oncotarget.com)
- These results indicate that triclabendazole severely disrupts spermatogenesis in the liver fluke from 48 h pt in vivo. (qub.ac.uk)
- Patient who shows alterations of the spermatogenesis and/or benign prostatic hyperplasia. (who.int)
- The effect of retinoids on spermatogenesis in adult male gerbils [Gerbillus cheesemani] was studied using light and electron microscopy. (who.int)
- The significance of spermatogenesis is that it releases mature male gametes. (vedantu.com)
- Spermatocytogenesis is the first one amongst the spermatogenesis process stages, and seems to be the male form of gametocytogenesis, in which spermatocytes with half the regular complement of genetic material are produced. (vedantu.com)
- Reduced, suppressed, or completely lacking spermatogenesis is a common factor associated with male infertility [ 1 ]. (oncotarget.com)
- a) Give a schematic representation showing the events of spermatogenesis in human male. (sarthaks.com)
- Our work provides previously unidentified in vivo evidence that TAp73 has a unique role in spermatogenesis that ensures the maintenance of mitotic cells and normal spermiogenesis. (uni-konstanz.de)
- The whole spermatogenesis process in humans is predicted to take place between 74 days (as per tritium-labeled biopsies) and 120 days (according to DNA clock measurements). (vedantu.com)
- Let us study the spermatogenesis process stages while we describe the process of spermatogenesis. (vedantu.com)
- a) Explain the process of spermatogenesis in humans. (sarthaks.com)
- This mineral also contributes to normal thyroid function, normal spermatogenesis (the process of formation of spermatoza). (itreallyworksvitamins.com)
- Systematic intake of the supplement will give you a number of benefits, ranging from a strong and long-lasting erection to supporting the process of spermatogenesis. (activemodepotency.com)
- Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. (oncotarget.com)
- a) Name the hormone that initiates spermatogenesis in humans. (sarthaks.com)
- The entire spermatogenesis steps can be divided up into multiple stages, each of which corresponds to a different cell type in humans. (vedantu.com)
- Schematically represent and explain the events of spermatogenesis in humans. (sarthaks.com)
- The effects of tributyltin (TBT) on the spermatogenesis of mud crab Scylla serrata were studied. (tubitak.gov.tr)
- The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. (oncotarget.com)
- However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. (oncotarget.com)
- Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. (oncotarget.com)
- Thus, our studies establish novel roles for Thm1 and Thm2 in adipogenesis, skeletal development, and spermatogenesis and provide novel models to study molecular mechanisms underlying ciliopathies. (ku.edu)
- To understand the importance of spermatogenesis let us first define spermatogenesis. (vedantu.com)
- La resonancia conception, RACC1: manuscript magnética describe presencia de estructura de aspecto tubular bilobulada compuesta por dos imágenes nodulares, las design, literature search, data collection, data or software cuales se ubican adyacentes a la pared vesical en su aspecto posterior, lateral y superior derecho de 27,4 × 15,4 × 11,0 mm. management. (bvsalud.org)
- The abnormal vitamin A metabolism contributed to damaged spermatogenesis in a gut microbiota dependent manner by using faecal microbiota transplantation. (bmj.com)
- a) Describe the events of spermatogenesis with the help of a schematic representation. (sarthaks.com)
- So there clearly is an important function for the ubiquitin ligase, at least during spermatogenesis," Ludwig added. (the-scientist.com)
- Violin plots show distribution of expression levels for Spermatogenesis-associated protein 1 (SMED30028825) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
- Expression of Spermatogenesis-associated protein 1 (SMED30028825) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
- Results We show that patients homozygous for a SCAPER mutation lack SCAPER expression in spermatogonia (SPG) and are azoospermic due to early defects in spermatogenesis, leading to the complete absence of meiotic cells. (bgu.ac.il)
- An inverse association between ACE2 receptor levels and spermatogenesis was noted. (medscape.com)