Sperm stem cells. Medical search

Men who lose the ability to produce sperm after chemotherapy might one day be able to regain their fertility. (newscientist.com)
Unfortunately, the drugs can also kill other rapidly dividing cells, including those that produce sperm. (newscientist.com)
Researchers successfully stored stem cells that produce sperm for months and used them to restore fertility in male mice. (nih.gov)
But prepubescent boys don't yet produce sperm that can be banked. (nih.gov)
A research team led by Dr. Sandra Ryeom at the University of Pennsylvania set out to understand how testicular endothelial cells (TECs) help SSCs thrive and produce sperm. (nih.gov)
Following transplantation, the PGCs restored the previously infertile mice's ability to produce sperm, which was then extracted and used to fertilise eggs in vitro . (bionews.org.uk)
If these technical hurdles can be overcome, a man with fertility issues theoretically could donate a patch of skin and let scientists use that to produce sperm that contains his DNA. (latimes.com)
This brings hope to men who are unable to produce sperm either as result of congenital problems, such as Sertoli-only cell syndrome where the cells that produce sperm do not form, or from surgery, infection or cancer treatments. (theconversation.com)
Estimates suggest that one in seven couples in the UK have difficulty conceiving, about one per cent of all men don't produce sperm and a further 3-4 per cent of men have a low sperm count. (ivf.net)
This is an interesting study which represents a further step forward in our abilities to produce sperm outside the body in a laboratory dish. (sciencemediacentre.co.nz)
To get around this problem, scientists have been investigating the possibility of removing the parts of the testicles that produce sperm and implanting them into another person-such as a brother or a father. (medicalxpress.com)
If the transplanted testes continue to produce sperm, they can be harvested at a later date, or even better, be returned to the original patient after completion of cancer treatment. (medicalxpress.com)
More testing is required to learn about the survival rates of testes in the neck and how long they will continue to produce sperm. (medicalxpress.com)
In the study, mouse cells in long-term culture restored the ability of mice after chemotherapy-induced infertility to produce sperm. (upi.com)
Six of the seven men had severe failure to produce sperm, and one man's sperm production was moderately affected. (www.nhs.uk)

For years researchers have been trying to find ways to grow and expand these cells from testicular biopsies donated by young patients prior to their cancer treatment, but until now, there has not been a consistently successful approach," Ryeom says. (nih.gov)
The researchers converted mouse embryonic stem cells into primordial germ cells (PGCs) using a cocktail of specific proteins . (bionews.org.uk)
For the first time, researchers have succeeded in creating human sperm and egg precursor cells from stem cells. (bionews.org.uk)
A team of Japanese researchers has created mouse eggs from stem cells and has fertilised them using IVF to produce baby mice. (bionews.org.uk)
Stem cells found in human skin can be turned into sperm precursor cells, US researchers have found. (bionews.org.uk)
Researchers in Japan have successfully grown sperm for the first time in a study that could eventually help preserve the fertility of cancer patients and help infertile men have children. (bionews.org.uk)
Human sperm have been created using embryonic stem cells for the first time in a scientific development which will lead researchers to a better understanding of the causes of infertility. (biologynews.net)
Researchers led by Professor Karim Nayernia at Newcastle University and the NorthEast England Stem Cell Institute (NESCI) have developed a new technique which has made the creation of human sperm possible in the laboratory. (biologynews.net)
Professor Nayernia says: "This is an important development as it will allow researchers to study in detail how sperm forms and lead to a better understanding of infertility in men - why it happens and what is causing it. (biologynews.net)
This demonstrates to researchers that the genes on a Y chromosome are essential for meiosis and for sperm maturation. (biologynews.net)
This week, a group of Japanese researchers from Kyoto University said they had figured out a way to turn embryonic stem cells into the more specific type of stem cell that makes sperm. (latimes.com)
The Japanese researchers were able to make sperm progenitor cells out of iPS cells, and some mouse pups were born as a result, but the entire process worked less well than with embryonic stem cells. (latimes.com)
To figure out how this was happening, the researchers first suspected two proteins -- Jak and STAT -- known to act together to help stem cells maintain their stem cell-ness. (hopkinsmedicine.org)
Researchers from Nanjing Medical University created functional primordial germ cells - cells that get passed down to the next generation - from the embryonic stem cells (ESCs) of mice. (gizmodo.com.au)
The researchers hope that the IVD sperm will provide a useful model for studying the development of sperm cells and the causes of male infertility. (bionews.org.uk)
In this study, the researchers found that a subset of lymphatic endothelial (LE) cells produce FGFs (Fgf5, 8 and 4 in particular), which promote stem cell self-renewal. (medindia.net)
The researchers grew embryonic stem cells together with cells from mice testicles and exposed them to chemicals and hormones that encouraged them to form sperm. (theconversation.com)
Researchers at Kyoto University in Japan have created fully functioning sperm from mouse embryonic stem cells . (discovermagazine.com)
In 2003, researchers succeeded in creating sperm-like cells , but the experiments could not produce successful pregnancies in mice. (discovermagazine.com)
Also in 2009, researchers in the current study discovered a way to coax early embryo cells-called epiblast cells -to turn into primordial germ cells , the precursors to sperm and eggs. (discovermagazine.com)
The researchers first created epiblast-like cells from a cocktail containing embryonic stem cells and several growth factors and proteins, which control cell proliferation, differentiation, and other activities. (discovermagazine.com)
The researchers were able to do this in their mouse study (and some mouse pups were born), but the process was a lot less successful than when they used embryonic stem cells. (discovermagazine.com)
The work is important for the insight that it gives to researchers looking at problems in sperm development and may one day help to develop new treatments for male infertility. (ivf.net)
The researchers concluded that Rhox10 is the most critical gene in the Rhox cluster, and that it plays a role in spermatogonial stem cell formation. (medicalxpress.com)
In laboratory experiments, the researchers found that one of the low sperm count-associated mutations significantly impaired transcription factor RHOXF2/2B's ability to regulate its target genes. (medicalxpress.com)
To accomplish this feat, the researchers coaxed mouse embryonic stem cells to turn into functional sperm-like cells, which were then injected into egg cells to produce fertile mouse offspring. (sciencemediacentre.co.nz)
Back in 2006, Japanese researchers discovered the capacity of skin cells to be "reprogrammed" into early embryonic cells that can generate an entire fetus, by expressing four central embryonic genes. (afhu.org)
For example, the researchers discovered that the gene "Eomes" pushes the cell towards placental stem cell identity and placental development, while the "Esrrb" gene orchestrates fetus stem cells development through the temporary acquisition of an extraembryonic stem cell identity. (afhu.org)
To uncover the molecular mechanisms that are activated during the formation of these various cell types, the researchers analyzed changes to the genome structure and function inside the cells when the five genes are introduced into the cell. (afhu.org)
For example, researchers must show evidence of the correct nuclear DNA content at specific meiotic stages, normal chromosome number and organization, and the capacity of germ cells to produce viable offspring. (esciencenews.com)
Next, the researchers mimicked the natural tissue environment of these precursor germ cells by exposing them to testicular cells as well as sex hormones such as testosterone. (esciencenews.com)
To provide final gold-standard proof of meiosis, the researchers injected these sperm-like cells into mouse egg cells and transferred the embryos into female mice. (esciencenews.com)
November 6, 2018 - Researchers discovered a set of brain cells that keeps track of time in mice. (nih.gov)
Similarly at InStem, researchers are dedicated to breaking boundaries in stem cell research while collaborating with labs and scientists to advance their discoveries. (news-medical.net)
US researchers say they will redouble their efforts to create human sperm from stem cells following the success of a Japanese study involving mice. (wordpress.com)
Researchers devise a technique for creating gametes from murine embryonic stem cells. (the-scientist.com)
Researchers harness the power of genome editing to track cell lineages throughout zebrafish development. (the-scientist.com)
Using patient-derived stem cells, researchers create laboratory neuron models that reflect a patient's response to a pain drug. (the-scientist.com)
Additional research is required to determine which cells to cultivate and when, as researchers question how much epigenetic memory is actually erased when creating stem cell models. (genengnews.com)
Researchers hope in future it may be possible to treat men with Type-1 diabetes with islet cells grown from their own spermatogonial stem cells (SSCs). (blogspot.com)
The researchers also found the Rhox10 is a master regulator of genes that control the germ cells' movement from one part of the testis to another that, due to a different chemical environment, helps the germ cells transform into SSCs. (ca.gov)
That's because researchers from Icahn School of Medicine at Mount Sinai, New York report in the journal, Nature, the ability to reprogram support cells in the eyes of blind mice to become photoreceptors, the light-sensing cells that enable sight. (ca.gov)
Now, a team of researchers from Nanjing Medical University has carried out a robust, step-by-step process that not only coaxed embryonic stem cells from mice to turn into functional sperm-like cells, but also injected them into egg cells to produce fertile mouse offspring. (basilita.com)
Next, the researchers exposed the cells to testicular cells - as well as sex hormones such as testosterone - in order to recreate the natural tissue environment of the cells. (basilita.com)
The researchers showed that these haploid stem cells were pluripotent-meaning they were able to differentiate into many other cell types, including nerve, heart, and pancreatic cells-while retaining a single set of chromosomes. (phys.org)
These cells will provide researchers with a novel tool for improving our understanding of human development, and the reasons why we reproduce sexually, instead of from a single parent. (phys.org)
The researchers were also able to show that by virtue of having just a single copy of a gene to target, haploid human cells may constitute a powerful tool for genetic screens. (phys.org)
The technology for versatile, grow-in-a-dish transplant tissue took a step toward clinical use Thursday when researchers announced they have found a safe way to turn skin cells into stem cells. (phys.org)
Currently, the best-studied stem cells are those that generate blood cells, even though these cells, which reside in bone marrow, are relatively inaccessible to researchers. (scienceblog.com)
A team of French researchers engineered healthy human cells to make a viral protein found in many tumors and watched the cells grow in a petri dish. (nytimes.com)
Muscle stem cells grown in large numbers in lab by Chinese researchers could help athletes and those with muscle-related injuries grow new muscles. (cas.cn)
The University of Macao (UM) researchers developed a new way to store stem cells at room temperature for a minimum of seven days without the loss of viability and biological activities, the university's latest news release said on Thursday. (cas.cn)
To avoid this problem, researchers are putting live kidney cells to work in dialysis machines. (tribuneindia.com)
Researchers at the University of Texas Southwestern Medical Center (UT Southwestern) have used embryonic stem cells from mice to grow muscle cells. (technologyreview.com)
However, many researchers have found it difficult to direct every stem cell in a culture to form a specific type of cell. (technologyreview.com)
The researchers then isolated these cells, creating a solution that consisted solely of muscle cells. (technologyreview.com)
Researchers have figured out how to grow human stem cells retrieved before treatment and reinjected years later. (upi.com)
Oct. 22 (UPI) -- Researchers have figured out how to grow human stem cells to help children treated for cancer who become infertile later in life. (upi.com)
In the past, researchers have restored sperm production in mice that were sterilized after treatment with the chemotherapeutic agent busulfan. (upi.com)
The researchers identified that testicular endothelial cells were a critical niche population for the maintenance and expansion of human cells in the lab. (upi.com)
To test the effects of any mutations identified in this gene, the researchers genetically modified cells in the laboratory to contain the mutated form of the gene. (www.nhs.uk)
When the researchers engineered cells to carry the mutated gene, they found that the protein produced by mutant NR5A1 was in the appropriate location of the cell (the nucleus), but its function (controlling the activation of genes) was impaired. (www.nhs.uk)
The researchers say that mutations in NR5A1 are associated with unexplained, severe failures in sperm production in otherwise healthy men. (www.nhs.uk)
Japanese researchers have produced mouse eggs from stem cells that bred healthy offspring, a breakthrough that may one day help treat human infertility. (time.com)
In the current study, published in the journal Science, the researchers first added growth factors and proteins to the stem cells to turn them into primordial germ cells. (time.com)
The researchers said the lab-created egg cells led to healthy pups less frequently than did natural mouse eggs, which were also fertilized and transferred to female mice in a control group. (time.com)
In the largest study of its kind, researchers find that sperm count in Western countries has more than halved in recent decades. (medicalnewstoday.com)
With these factors in mind, a group of researchers recently set out to conduct a large-scale systematic review and meta-analysis of sperm count trends. (medicalnewstoday.com)
Functioning sperm have been created in a laboratory in China, say researchers. (medicalnewstoday.com)

In addition to previous successes in deriving somatic cell types, recent studies have shown that both mouse and human ES cells can also give rise to primordial germ cells (PGCs) in culture. (nih.gov)
These mouse germ cells appear to be capable of undergoing meiosis and forming both male and female gametes. (nih.gov)
Although the full function of these ES-derived germ cells and gametes remains to be demonstrated, these findings open the door for undertaking new types of reproductive studies and novel approaches in regenerative medicine. (nih.gov)
After further differentiation, these in vitro derived germline stem cells expressed markers which are specific to primordial germ cells, spermatogonial stem cells, meiotic (spermatocytes) and post meiotic germ cells (spermatids and sperm). (biologynews.net)
These results indicated maturation of the primordial germ cells to haploid male gametes - called IVD sperm - characterised by containing half a chromosome set (23 chromosomes). (biologynews.net)
Scientists had previously demonstrated that it's possible to generate germ cells (sexual reproductive cells, like an ovum or sperm) from stem cells. (gizmodo.com.au)
the gene expression profile of human germ cells is similar to those of mice, but different in important ways. (gizmodo.com.au)
The technique involved induced signaling of BMP4 , a protein long known to be required for the generation of germ cells . (discovermagazine.com)
Then, using their method devised a couple years ago, they turned those epiblast cells into primordial germ cells. (discovermagazine.com)
A glimpse into the future is provided with information from EST, protein, and genome databases that already have an impact on progress in our understanding of the male germ cell. (powells.com)
For example, Rhox genes may have roles in testicular tumors that arise from germ cells that failed to convert into spermatogonial stem cells and thus are "frozen" at the pro-spermatogonia stage. (medicalxpress.com)
However, the end result was not working sperm and eggs, but so-called germ cells that could potentially mature to become viable for fertility. (worldtruth.tv)
"Germ cells are 'immortal' in the sense that they provide an enduring link between all generations, carrying genetic information from one generation to the next," Azim Surani, professor of physiology and reproduction at the University of Cambridge, said in a press release. (worldtruth.tv)
Some of these will become germ cells, and will then become sperm or eggs. (worldtruth.tv)
They next used a protocol they developed a couple years ago to mature those cells into primordial germ-like cells, then used molecular markers to select those cells in the culture that were most likely to have the ability to form sperm. (stemcellsportal.com)
In the not-too-distant future, it may be possible to use cells from almost any part of the body to create these germ cells, also known as gametes. (statnews.com)
Reproducing germ cell development in vitro has remained a central goal in both reproductive biology and reproductive medicine," says co-senior study author Jiahao Sha of Nanjing Medical University. (esciencenews.com)
Several studies have reported the successful generation of germ cells from stem cells, but they did not fully evaluate the functionality of the germ cells or provide proof for all key hallmarks of meiosis. (esciencenews.com)
Recently, a panel of reproductive biologists proposed gold standard criteria to prove that the major events of meiosis have taken place in engineered germ cells. (esciencenews.com)
The first step was to expose mouse embryonic stem cells (ESCs) to a chemical cocktail, which coaxed the ESCs to turn into primordial germ cells. (esciencenews.com)
Under these biologically relevant conditions, the ESC-derived primordial germ cells underwent complete meiosis, resulting in sperm-like cells with correct nuclear DNA and chromosomal content. (esciencenews.com)
Here we show that changes in the stem cell orientation with respect to the niche during ageing contribute to the decline in spermatogenesis in the male germ line of Drosophila . (nature.com)
The reprogrammed germ-like cells were unable to fertilize eggs, however. (the-scientist.com)
The group, based at Newcastle University, grew these cells in a laboratory and treated them so they developed into male reproductive cells called germ cells. (thenakedscientists.com)
The SSC itself forms from primordial germ cells. (ca.gov)
The key genetic switches that help these germ cells give rise to SSCs was not well understood. (ca.gov)
Further analysis, indicated Rhox10 was key to driving the development of germ cells into SSCs. (ca.gov)
Scientists have previously generated germ cells from stem cells , but the functionality of the germ cells was not proven, nor was there evidence of all the key hallmarks of meiosis. (basilita.com)
Acceptable evidence includes proof that the DNA has correct nuclear content at specific meiotic stages, that there is a normal number of chromosomes, that the chromosomes are correctly organized, and that the germ cells can produce viable offspring. (basilita.com)
Reproducing germ cell development in this way has therefore been a key goal for both reproductive biologists and reproductive medicine. (basilita.com)
The team started by exposing mouse embryonic stem cells (ESCs) to a chemical cocktail that caused the ESCs to turn into primordial germ cells. (basilita.com)
Because their genetic content is equivalent to germ cells, they might also be useful for reproductive purposes. (phys.org)
There are about 35,000 stem cells per testis, constituting about 0.03% of all germ cells in the testis. (nih.gov)
The investigators aim at generating haploid stem cells from human germ cells that are a useful tool in genetic research and screening. (clinicaltrials.gov)
The investigators aim at generating haploid stem cells from human haploid germ cells. (clinicaltrials.gov)
Collected germ cells will be cultured in medium. (clinicaltrials.gov)
The germ cell cultures will be infected with reprograming factors. (clinicaltrials.gov)
Spermatogenesis is a highly organized process, requiring just the right environment, or 'niche,' around the germ line stem cells," said Ralph L. Brinster, professor of reproductive physiology at Penn. (scienceblog.com)
Male infertility can be caused either by defective germ cells or by a testicular environment that fails to promote proper spermatogenesis," Brinster said. (scienceblog.com)

Scientists haven't yet found a way to grow sperm-producing stem cells, called spermatogonial stem cells (SSCs), in culture. (nih.gov)
Scientists in Japan have successfully generated viable sperm cells from embryonic stem cells in mice. (bionews.org.uk)
It is the first time scientists have reported producing properly functioning eggs using this type of stem cell. (bionews.org.uk)
US scientists have succeeded in creating early-stage sperm and egg cells from human embryonic stem cells (ES cells). (bionews.org.uk)
It will also allow scientists to study how cells involved in reproduction are affected by toxins, for example, why young boys with leukaemia who undergo chemotherapy can become infertile for life - and possibly lead us to a solution. (biologynews.net)
Mouse stem cells used to produce eggs, Japanese scientists. (latimes.com)
Now, cell scientists at the Johns Hopkins University School of Medicine have identified key molecular players responsible for this reversion in fruit fly sperm cells. (hopkinsmedicine.org)
Scientists from China have made history by taking a cell that's not a sperm cell and then used it to create a live animal. (gizmodo.com.au)
Theoretically, human stem cells are likely capable of performing the same trick, but scientists still have to prove that. (gizmodo.com.au)
UK scientists have created human sperm cells in the laboratory for the first time. (bionews.org.uk)
Scientists in China have successfully made mouse sperm cells from embryonic stem cells. (theconversation.com)
Scientists have been trying for many years to create viable sperm and egg cells from embryonic stem cells, which can become any type of tissue in the body. (discovermagazine.com)
More recently in 2009, scientists at Newcastle University claimed to have created early-stage human sperm from embryonic stem cells. (discovermagazine.com)
Many biologists doubted the research team's results, and the study, which was published in the journal Stem Cells and Development , was later retracted after editors found that the scientists plagiarized a previous paper . (discovermagazine.com)
SCIENTISTS have created a living embryo in a laboratory without using either egg or sperm in ground-breaking but hugely controversial experiments. (express.co.uk)
Scientists have for the first time managed to create sperm from mouse stem cells capable of fertilising eggs and resulting in live births. (ivf.net)
Scientists in China have created functioning sperm from mice stem cells in the laboratory. (sciencemediacentre.co.nz)
Therefore it's reassuring to see that the scientists in this study have paid very careful attention to this and their results appear to show that the sperm-like cells they have made are genetically normal. (sciencemediacentre.co.nz)
Scientists from Cambridge University have created artificial human eggs and sperm for the first time, using human embryonic stem cells and skin cells. (worldtruth.tv)
The scientists identified a gene known as SOX17, which decides which cells become sperm and egg cells. (worldtruth.tv)
However, this doesn't mean that men and women can donate any cells instead of sperm and eggs when they visit a fertility clinic - but the scientists hope the experiment will shed more light on the study of human genetics. (worldtruth.tv)
The Newcastle scientists reported this month that they had produced the sperm in a laboratory and that it could one day help infertile men father children. (nbcnews.com)
SALT LAKE CITY - New research from scientists at Huntsman Cancer Institute (HCI) at the University of Utah and collaborators at University of Utah Health (U of U Health) sheds light on the complex process that occurs in the development of human sperm stem cells. (huntsmancancer.org)
Using genome analysis tools, scientists outlined the multistage process that sperm stem cells undergo during their normal development. (huntsmancancer.org)
In the study, scientists examined all of the genes that turn 'on' or 'off' in any given cell during normal development. (huntsmancancer.org)
Scientists in China have finally succeeded in creating functioning sperm from mice in the laboratory. (esciencenews.com)
Earlier this month, British scientists at Newcastle University in England reported the creation of spermatozoa from human stem cells, the official announcement of which was published in the journal Stem Cells and Development. (cellmedicine.com)
Organoids grown from genetically edited stem cells are giving scientists a new tool to screen drugs and test treatments. (the-scientist.com)
Scientists have succeeded in transforming sperm stem cells into the pancreatic cells that generate insulin. (blogspot.com)
Using state-of-the art microscopy, scientists have peered inside cardiac cells while they beat, revealing tube-like structures that buckle and then snap back into shape, much like shock absorbers. (gizmodo.com.au)
Scientists believe that stem cell research can be used to treat medical conditions including Parkinson's disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis and rheumatoid arthritis. (cnn.com)
Scientists who research stem cells are trying to identify how undifferentiated stem cells become differentiated as serious medical conditions, such as cancer and birth defects, are due to abnormal cell division and differentiation. (cnn.com)
Scientists believe stem cells can be used to generate cells and tissues that could be used for cell-based therapies as the need for donated organs and tissues outweighs the supply. (cnn.com)
Functioning sperm that could one day be used to treat infertility in men have been created in a laboratory by scientists in China, according to a report in Cell Stem Cell . (basilita.com)
Scientists have created sperm that can successfully reproduce. (basilita.com)
Scientists from The Hebrew University of Jerusalem, Columbia University Medical Center (CUMC) and The New York Stem Cell Foundation Research Institute (NYSCF) have succeeded in generating a new type of embryonic stem cell that carries a single copy of the human genome, instead of the two copies typically found in normal stem cells. (phys.org)
In this study, the scientists triggered unfertilized human egg cells into dividing. (phys.org)
Until Yamanaka proved differently, scientists believed that this could only be achieved with stem cells harvested from embyros, the foundation said in a statement. (phys.org)
AP) -- Five scientists have won prestigious research awards for developing a life-saving leukemia treatment and for advances in "reprogramming" DNA, which led to a new kind of stem cell. (phys.org)
The simple recipe scientists earlier discovered for making adult stem cells behave like embryonic-like stem cells just got even simpler. (phys.org)
Their point that ES cells will lead to some Brave New World scenario - not likely unless iPSC fail to live up to their promise and evil scientists from Klandathu take over the world. (scienceblogs.com)
German scientists have designed a new method to use iron-coated sperm as a drug delivery system for gynecological cancer , according to MIT Technology Review . (sciencemag.org)
Scientists first douse bull sperm in the common cancer chemotherapy drug Doxorubicin, which they readily absorb, and then coax the sperm into tiny, laser-printed, iron-coated harnesses. (sciencemag.org)
Scientists have successfully restored sperm production in once-infertile mice by transplanting specialized cells that are critical to sperm development. (scienceblog.com)
Scientists at the University of Pennsylvania School of Veterinary Medicine have successfully transplanted specialized cells that are critical to sperm development in mice, restoring sperm production in once-infertile animals. (scienceblog.com)
The Brinster group's technique for transplanting Sertoli cells will likely allow scientists to study stem cells' specialized environment in a way that has not been possible before. (scienceblog.com)
Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells , to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells . (wikipedia.org)
In many kinds of tumor cells, for instance, scientists find proteins produced by endogenous retroviruses. (nytimes.com)
Placentas make viral proteins, and scientists have found that some types, known as syncytins, fuse together placental cells, a crucial step in fetal development. (nytimes.com)
GEN ) - Scientists say they have developed a novel technique to create expanded potential stem cells (EPSCs) of both pig and human cells. (cbhd.org)
Research by an EU-supported international team of scientists has shown that polychlorinated biphenyls (PCBs) - synthetic organic chemicals found widely in the environment and absorbed in the diet - may damage sperm. (innovations-report.com)
The scientists used Sperm Chromatin Structure Assay (SCSA) to test the integrity of sperm samples from the majority of the volunteers and assess the level of DNA damage - the DNA fragmentation index (DFI). (innovations-report.com)
Scientists from China said Thursday they have finally succeeded in creating functioning sperm from mouse embryonic stem cells in the laboratory, a major scientific development that could some day lead to a treatment for male infertility in humans. (cas.cn)
An international team of scientists headed by biologists at UC San Diego has discovered that an important class of stem cells known as human "induced pluripotent stem cells," or iPSCs, which are derived from an individual's own cells, can be differentiated into various ty. (cas.cn)
Scientists have developed a way to produce a pure source of muscle cells, a technique that might one day prove useful for treating muscle-related diseases. (technologyreview.com)
Scientists say that the research, while still in its early stages, could eventually lead to a cell-based therapy for patients with muscular dystrophy and other muscle-related diseases. (technologyreview.com)
In lab experiments, scientists often end up with a mixture of cells that, when injected into an animal, form large clusters resembling a tumor. (technologyreview.com)
In previous efforts, scientists - including the current group - have been able to create sperm and egg cells in the lab, but they weren't able to produce healthy offspring from those cells. (time.com)
Four weeks later, the scientists removed them again, isolated immature egg cells from the ovaries and allowed them to mature in a dish. (time.com)
This allowed the company to begin searching for the first patients who might qualify for this phase 1 clinical trial, which means scientists are trying to determine the safety of introducing these cells into a human. (cnn.com)
In conjunction with stem cell research, Foundation scientists also apply patented processes to help diagnose male reproductive tract disorders. (wikipedia.org)

Dr Allan Pacey, a leading researcher into male fertility at the University of Sheffield, said: 'This is quite a step forward in developing a process by which sperm could be made for infertile men, perhaps by taking as a starting point a cell from their skin or from something like bone marrow. (bionews.org.uk)
Banked sperm-producing stem cells have been used to restore sperm production in monkeys made infertile by chemotherapy treatment. (bionews.org.uk)
If the technique does work for humans, it will be possible to correct genetic defects in the stem cells of infertile patients and use them to make sperm cells capable of fertilising eggs. (gizmodo.com.au)
This is a significant breakthrough and makes the possibility of generating functional sperm for men who are infertile that bit closer. (theconversation.com)
Our finding that Rhox10 is critical for spermatogonial stem cells, coupled with the finding that human RHOX genes are mutated in infertile men, suggests that mutations in these genes cause human male infertility. (medicalxpress.com)
But to make sperm for infertile men, it would probably be necessary to use an adult cell from some part of their body. (sciencemediacentre.co.nz)
Brinster and colleagues worked with Steel mutant mice, which are congenitally infertile due to a Sertoli cell defect. (scienceblog.com)
While several assisted reproductive technologies, such as in vitro fertilization or intracytoplasmic sperm injection, are now available for patients with low sperm counts, infertile patients with Sertoli cell defects have limited options. (scienceblog.com)
The technique developed by Brinster and his colleagues may provide a new way of replacing defective Sertoli cells with healthy ones, which may initiate normal spermatogenesis in some infertile patients. (scienceblog.com)
But cancer treatments, including chemotherapy and radiation, leave most boys infertile because sperm-producing stem cells are killed. (upi.com)

This is the first study to create healthy and fertile offspring from germline cells generated from embryonic stem cells. (bionews.org.uk)

If future studies in humans are successful, storing stem cells could potentially help preserve fertility in young boys undergoing chemotherapy. (nih.gov)
The findings could help restore fertility to cancer patients, and could provide a new way of studying the development of sperm cells in the lab. (bionews.org.uk)
The IVD sperm will not and cannot be used for fertility treatment. (biologynews.net)
Stem cells could lead to future fertility treatments, study. (latimes.com)
Fertility not the only thing you should be worried about if you have a Low sperm count, finds a new study. (medindia.net)
Dr Allan Pacey, honorary secretary of the British Fertility Society and a senior lecturer in andrology, said, 'To be able to make functional sperm under controlled conditions in the laboratory will be very useful to study the basic biology of sperm production. (ivf.net)
Infertility in general, and especially male fertility, gets little attention considering how common of a problem it is-about 15 percent of couples are affected, and nearly half of these cases are due to male infertility ," said Miles Wilkinson, PhD, professor of reproductive medicine at UC San Diego School of Medicine and senior author of the Cell Reports study. (medicalxpress.com)
Rhox genes may also be useful for regenerative medicine approaches to restoring fertility through therapy with spermatogonial stem cells. (medicalxpress.com)
Early Sperm and Male Fertility Loss Linked to Deficient Stem Cell. (genengnews.com)
Using fertilized eggs left over at fertility clinics is also controversial because removing the stem cells destroys them. (cnn.com)
How many Microdissection TESE (Testicular Sperm Extraction) specialists are working at this fertility clinic? (placidway.com)
What is the success rate of the Microdissection TESE (Testicular Sperm Extraction) procedure at this fertility clinic? (placidway.com)
For patients from all around the globe looking for Microdissection TESE (Testicular Sperm Extraction) options, Albuquerque, United States is an ideal destination with plenty of trustworthy fertility clinics to choose from. (placidway.com)
Background: In male pre-pubertal cancer patients, radiation and chemotherapy impact future fertility by eradication of spermatogonial stem cells (SSCs). (elsevier.com)
The impact of persistent organochlorine pollutants (POPs), of which PCBs and DDT are two, on human fertility is still unknown and there are limited and contradictory findings so far as to whether PCBs and DDT/DDE damage human sperm. (innovations-report.com)

That's because, for the first time, infertility has been reversed in a male primate using an injection of stem cells. (newscientist.com)
The research, published in the journal Cell , may someday help treat infertility in humans. (discovermagazine.com)
Mutations in the RHOX transcription factor family inhibit sperm development and are associated with infertility in men. (medicalxpress.com)
The research, published in Cell Stem Cell , provides a platform for generating sperm cells that could one day be used to treat male infertility in humans, say the authors. (sciencemediacentre.co.nz)
Infertility due to cell failure or cancer treatment could cease to be the emotionally shattering issue it is for many families and individuals. (statnews.com)
Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man's life and may have application for treating some cases of male infertility, including those caused by chemotherapy before puberty. (elsevier.com)
But according to Miles Wilkinson, professor of reproductive medicine at UC San Diego School of Medicine, infertility issues can just as likely be due to problems with sperm production in the male. (ca.gov)
The study results, funded in part by CIRM and published yesterday in Cell Reports , may help provide a path toward new treatment options for male infertility. (ca.gov)
To get at a cellular and molecular understanding of infertility, the team focused on the function of spermatogonial stem cells (SSCs). (ca.gov)
A CDC study in 2002 found that male infertility caused 7.5% of all sexually experienced men under 45 years to seek help at some time, 14% of whom were diagnosed with sperm or semen problems. (basilita.com)
Infertility affects a growing number of people throughout the entire world, and that's the reason why couples decide to take Microdissection TESE (Testicular Sperm Extraction). (placidway.com)
In men, some common infertility causes are low sperm count and poor sperm health. (placidway.com)
Microdissection TESE (Testicular Sperm Extraction) helps patients struggling with infertility conceive, have a normal pregnancy, and give birth to a healthy baby. (placidway.com)
Male sperm quality, which is steadily declining in Western countries, accounts for 40 percent of infertility problems among couples. (nocamels.com)
This case-control study tested whether men seeking infertility treatment for unexplained reduced sperm counts had genetic mutations in a gene called NR5A1. (www.nhs.uk)
The study recruited 315 French men who had unexplained reduced sperm counts and who sought infertility treatment. (www.nhs.uk)
Nevertheless, the advance sheds light on how precursor cells eventually develop into sperm or egg cells, a scientific understanding that could in itself aid infertility treatments. (time.com)

ESCs are cells that form in the embryo and eventually give rise to sperm. (gizmodo.com.au)
Professor Karim Nayernia and colleagues at the Georg-August University in Göttingen, Germany, took stem cells from a mouse embryo that was only a few days old and grew these cells in the laboratory. (medgadget.com)
The experimental research combined two types of stem cells and created a viable embryo - which the team say would provide an unlimited stock for medical research. (express.co.uk)
As published in Cell Stem Cell , Dr. Yossi Buganim of HU's Department of Developmental Biology and Cancer Research and his team discovered a set of genes capable of transforming murine skin cells into all three of the cell types that comprise the early embryo: the embryo itself, the placenta and the extraembryonic tissues, such as the umbilical cord. (afhu.org)
Recently, attempts have been made to develop an entire mouse embryo without using sperm or egg cells. (afhu.org)
These attempts used the three early cell types isolated directly from a live, developing embryo. (afhu.org)
Sperm-derived factors play an important role in nucleus reprogramming and cytoskeleton remodeling during SCNT embryo development. (biomedcentral.com)
Totipotent stem cells that develop into cells that make up all the cells in an embryo and fetus. (cnn.com)
These stem cells have the features of the first cells in the developing embryo and can develop into any type of cell, according to the research team from the LKS Faculty of Medicine of The University of Hong Kong (HKUMed), the Wellcome Sanger Institute, and the Friedrich-Loeffler-Institut in Germany. (cbhd.org)
Stem cells are the body's growth and maintenance units that are able to differentiate indefinitely into specialised cell types, first in the growing embryo into various organ cell types, and later form the body's repair mechanism by producing cells when the tissue they reside in is damaged. (cas.cn)
These stem cells are found in most tissue types as well as in the embryo. (cas.cn)
Once again, Perlingeiro looked to basic developmental research and found that, during normal muscle formation in the embryo, stem cells that become very early versions of muscle cells display certain surface molecules, or markers. (technologyreview.com)
In vitro fertilization (IVF) is the process of fertilising an egg with a sperm in the laboratory to produce an embryo. (ivf.net)
The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). (cshlpress.com)

Like all stem cells, each of the nine stem cells in the fly testis divides to form two daughter cells: One stays a stem cell and the other differentiates into an adult cell, in this case, a sperm cell. (hopkinsmedicine.org)
To figure out what might cause sperm cells to revert, or dedifferentiate, Matunis's research team genetically altered the flies so that both cells become sperm, reducing the stem cell population in the testis to nothing. (hopkinsmedicine.org)
Sperm production depends on the constant number of sperm stem cells in the testis. (medindia.net)
In tissues like the testis and ovary of the fruitfly Drosophila and intestine of mammalians, stem cells are clustered in their specialized home where self-renewal-promoting factors are abundant: the stem cell niche. (medindia.net)
However, sperm stem cells are not clustered in mouse testis, but are highly motile and widely dispersed across the basement membrane. (medindia.net)
Asst. Prof. Kitadate said, "The lymphatic endothelial cells in the testis were described via the use of electron microscopy in the 1970s, but had scant attention paid to them for a long time. (medindia.net)
Prof. Yoshida said, "Sperm stem cells migrate in the testis to intake FGFs, just as cows move around the meadow to eat the grass which they live on. (medindia.net)
The Testis: From Stem Cell to Sperm Function presents the proceedings of the XVth Testis Workshop held in Louisville, Kentucky. (powells.com)
Topics covered include testis development and differentiation, paracrine and endocrine interactions, genetics and cell biology of spermatogenesis, epididymal maturation and fertilization, and genetic defects and remedies. (powells.com)
The first two chapters provide a useful historical perspective of testis physiology and formulate compelling research questions about important aspects of sperm formation and function. (powells.com)
This prologue sets the scene for the remainder of the volume that follows a logical progression, as the title implies, from stem cell to cell function, but that is necessarily preceded by sex determination, the quintessential requirement for there being a testis in the first place. (powells.com)
Developing download The Testis: From Stem server in the goods sent one of the 14 people. (atlantaflyfishingschool.com)
L had download The Testis: From Stem Cell to Sperm Function tools help effect from maintenance Seer. (atlantaflyfishingschool.com)
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The download The Testis: From Stem Cell to section careers as readiness those date books that have an Associate word of the search of the AT and the Pedagogy problem opens the cans from the heart of an boat as sale if that list employed focused with the a of saver. (atlantaflyfishingschool.com)
So when the gene is deleted, not enough SSCs develop in the testis, leading to low sperm counts. (ca.gov)
Furthermore, the total number of Sertoli cells per testis was estimated using the disector method. (nih.gov)
Subsequently, estimates were made of the total numbers of the different spermatogonial cell populations per testis. (nih.gov)
Much of the volume of a mammalian testis consists of tightly coiled seminiferous tubules that hold mature sperm. (scienceblog.com)
Seminiferous tubules are lined with Sertoli cells, which are thought to nurture sperm cells as they develop and facilitate their eventual passage out of the testis. (scienceblog.com)
Transplantation of testicular cells and tissues has been studied for the investigation of immunology of the testis, which is an immunologically privileged organ. (medicalxpress.com)
They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. (cshlpress.com)

Their findings outlined four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a "quiescent" state, to a "proliferation" state during which stem cells divide, to a final "differentiation" state when stem cells mature to become sperm. (huntsmancancer.org)
Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture. (nig.ac.jp)
Through improvements of culture conditions, we achieved efficient propagation of the SSCs and differentiation to sperm that gave rise to offspring. (nig.ac.jp)
Oxygen at the concentration of air proved to be detrimental for sperm differentiation from SSCs. (nig.ac.jp)
SSCs that express green fluorescent protein grow in propagation culture (left and middle panels), while they differentiated into sperm in differentiation culture (the right panel). (nig.ac.jp)
Derivation and differentiation of haploid human embryonic stem cells, Nature (2016). (phys.org)
Advanced biomaterials have significantly contributed to three-dimensional cell culture systems in recent decades, and more unique and complex biomaterials have been proposed for improving stem-cell proliferation and controlled differentiation. (wikipedia.org)
The sperm/oocyte decision in the hermaphrodite germline of Caenorhabditis elegans provides a powerful model for the characterization of stem cell fate specification and differentiation. (nih.gov)
Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to arise. (rochester.edu)
As cells divide during differentiation, changes in gene expression provide each cell type with a specific identity and function. (rochester.edu)
For these reasons as well as others, zebrafish have become a prevailing model for studying cell state transitions during vertebrate differentiation and in carcinogenesis. (rochester.edu)
Humans have four sets of Hox genes, numbering 39 genes altogether, all of which aid in the differentiation of cells by location. (wikipedia.org)

The promise of stem cell therapy may lie in uncovering how adult cells revert back into a primordial, stem cell state , whose fate is yet to be determined. (hopkinsmedicine.org)
Uncovering how adult cells revert back into a primordial, stem cell state is one of the key steps in bringing to fruition the promise of stem cell therapy. (medindia.net)
Reconstruction of male and female gamete development in culture from either embryonic stem cells or induced pluripotent stem cells (adult cells that are reprogrammed to a state similar to an embryonic stem cell) remains a great challenge in reproductive biology. (theconversation.com)
AP) -- The Balzan Foundation says its prize for the biology of stem cells has gone to a Japanese researcher for discovering a way to transform adult cells into cells with the characteristics of stem cells. (phys.org)
In a similar sense, when the gene expression patterns of normal adult cells change inappropriately, the cell identity also changes, and this can lead to carcinogenesis. (rochester.edu)

A team led by Professor Karim Nayernia, now Professor of Stem Cell Biology at Newcastle University, began with mouse embryonic stem (ES) cells which they sorted in order to isolate cells that were capable of becoming sperm precursor cells. (ivf.net)
Karim Nayernia, who led the sperm research at Newcastle University, was unavailable to comment. (nbcnews.com)

The research team, from the North-East England Stem Cell Institute (NESCI) in Newcastle, UK, treated human ES cells with a chemical to prompt them into becoming germline stem cells - stem cells that are found in the reproductive organs and give rise to eggs and sperm. (bionews.org.uk)
Creating eggs and sperm from stem cells: the next big thing in assisted reproduction? (statnews.com)
These haploid cells cannot divide to make more eggs and sperm. (phys.org)

These were shown to produce fully mature, sperm called scientifically, In Vitro Derived sperm (IVD sperm). (biologynews.net)
They then selected out these germline stem cells and continued to grow them in the presence of chemicals to encourage them to develop further into mature sperm cells. (bionews.org.uk)
However, it's important to note that the sperm-like cells produced in the study were not fully mature sperm as we might know them. (sciencemediacentre.co.nz)
The next step for them is to see if they can grow mature sperm from these stem cells. (thenakedscientists.com)
Through a multistep process within the male reproductive system, SSCs form into mature sperm cells capable of fertilizing an egg. (ca.gov)

When these five factors were added to SSCs grown in the laboratory, the stem cells survived without the presence of TECs. (nih.gov)
The Newcastle University team have developed a method for establishing early stage sperm from human embryonic stem cells in the laboratory. (biologynews.net)
Anna Smajdor, a researcher in medical ethics at Imperial College London, described the work as 'a hugely significant breakthrough', but warned that, 'being able to create these cells in the laboratory will pose a serious conceptual challenge for our society. (ivf.net)
Who is the father of offspring born from laboratory sperm? (ivf.net)
Therefore before laboratory-made sperm could be used to produce children, extensive safety testing would have to be carried out. (sciencemediacentre.co.nz)
Fluxion Biosciences announced today that the Karp Laboratory at the Brigham and Women's Hospital (BWH) has purchased the BioFlux 1000 system, which will be applied in their stem cell homing research. (news-medical.net)
Retrieved on May 25, 2020 from https://www.news-medical.net/news/20110512/BWH-Karp-Laboratory-acquires-BioFlux-1000-system-for-stem-cell-homing-research.aspx. (news-medical.net)
The study noted that regenerative medicine specialists have been using a type of cell commonly found in the skin called the fibroblast because it is easily obtained from skin samples, grows well in culture, and can be manipulated in the laboratory to de-differentiate into a primordial state known as the induced pluripotent stem cell. (genengnews.com)
According to the Technion, "many studies on the question of the connection between sperm quality and the radiation emitted by cell phones reached different and non-uniform conclusions, since they were carried out under different conditions (laboratory experiments on tissue, experiments in laboratory animals, etc.) and did not always address all the relevant variables. (nocamels.com)
In the Murphy laboratory, we use the zebrafish model, mammalian stem cells, and human cancer cell lines, to investigate how epigenetic marks control gene expression patterns, and drive cell state transitions. (rochester.edu)
Dr. Ann Kiessling, the founder of Bedford Stem Cell Research Foundation, is the Laboratory Director. (wikipedia.org)

We knew from our previous work that cells destined to be sperm could revert back to being stem cells, but we didn't know how," says Erika Matunis, Ph.D. , an associate professor of cell biology at the Johns Hopkins University School of Medicine. (hopkinsmedicine.org)
A new mechanism for stem cell number control was revealed by Asst. Prof. Yu Kitadate and Prof. Shosei Yoshida (developmental biologists at the National Institute for Basic Biology within the National Institutes of Natural Sciences in Japan) and Prof. Benjamin Simons (a theoretical physicist at the University of Cambridge in the UK). (medindia.net)
In biology, when an egg is fertilized by sperm, it divides into a group of cells called a blastocyst, which then develops into a fetus or the placenta. (worldtruth.tv)
Although the editor of Stem Cells and Development, Graham Parker, initially announced on this journal's website that the sperm study 'is being retracted', without offering any explanation, it was the journal Nature which quoted him as having said that two paragraphs in the article's introduction were found to have been plagiarized, and were taken from a 2007 review in the journal Biology of Reproduction. (cellmedicine.com)
Nicoya has designated the Institute for Stem Cell Biology and Regenerative Medicine (InStem) as the new OpenSPR Centre of Excellence in collaboration with Dr. Ramaswamy (Senior Professor at InStem) and his lab. (news-medical.net)
Retrieved on May 26, 2020 from https://www.news-medical.net/news/20181115/Nicoya-designate-the-Institute-for-Stem-Cell-Biology-and-Regenerative-Medicine-as-the-OpenSPR-Centre-of-Excellence.aspx. (news-medical.net)
The findings were presented at the annual meeting of the American Society of Cell Biology in Philadelphia. (blogspot.com)
This work is an outstanding example of how collaborations between different institutions, on different continents, can solve fundamental problems in biomedicine," said Dieter Egli, PhD, principal co-author of the study, and Assistant Professor of Developmental Cell Biology in Pediatrics at Columbia University Medical Center and a Senior Research Fellow at the NYSCF Research Institute and a NYSCF-Robertson Investigator. (phys.org)
Yamanaka said the idea of reversing the fate of already specialised cells, then a "no-can-do" in biology, came to him when studying the experiments that produced the first cloned frogs, in the 1970s, and Dolly the sheep in 1996, according to the foundation statement. (phys.org)
I believe Dr. Brinster's new results have catapulted the spermatogenic stem cell system into a position of maximum experimental flexibility among all other stem cell systems in the body," said John R. McCarrey, professor of cell and molecular biology at the University of Texas at San Antonio, who was not involved in this work. (scienceblog.com)
1 Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America. (nih.gov)
Their work ("Establishment of porcine and human expanded potential stem cells"), published in Nature Cell Biology , also offers great potential for studying human development and regenerative medicine, they added. (cbhd.org)
This work relies on classic genetics and developmental biology methods, new DNA sequencing technologies, and bioinformatics applications, to map the genomic locations of various proteins and epigenetic marks as they change during cell state transitions. (rochester.edu)
Rita Perlingeiro , assistant professor of developmental biology at UT Southwestern, says that embryonic stem cells may be the key to reversing muscular dystrophy's debilitating effects. (technologyreview.com)
This book examines recent progress in our understanding of the biology of these cells, how they are regulated, and opportunities for using them in disease therapies. (cshlpress.com)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. (cshlpress.com)

The team also believe that studying the process of forming sperm could lead to a better understanding of how genetic diseases are passed on. (biologynews.net)
These contain the same genetic material that fully formed sperm do, but they do not have the ability to swim as the sperm tail is not yet formed properly. (sciencemediacentre.co.nz)
Certain plant stem cells rarely divide, a study shows, possibly fending off an accumulation of potentially harmful genetic mutations in some species. (the-scientist.com)
Rhox 10: a genetic "bus" that "drives" sperm stem cells toward sperm production. (ca.gov)
This study has given us a new type of human stem cell that will have an important impact on human genetic and medical research," said Nissim Benvenisty, MD, PhD, Director of the Azrieli Center for Stem Cells and Genetic Research at the Hebrew University of Jerusalem and principal co-author of the study. (phys.org)
Since the stem cells described in this study were a genetic match to the egg cell donor, they could also be used to develop cell-based therapies for diseases such as blindness, diabetes, or other conditions in which genetically identical cells offer a therapeutic advantage. (phys.org)
Yes, ES cells will largely be supplanted by iPSC, because the cells will allow us to study a far broader group of individuals - often with specific medical and genetic conditions - and will allow us to bypass the immunologic issues that would prevent easy implementation of ES cell technologies. (scienceblogs.com)
No other sperm bank does more genetic testing! (cryobank.com)
Accumulated research knowledge on this subject shows that sperm quality is affected by congenital genetic factors, but also by environmental variables. (nocamels.com)
The most well known, Duchenne muscular dystrophy, is caused by a genetic mutation that disrupts the formation of dystrophin, an important protein involved in the formation of muscle cells. (technologyreview.com)
In normal embryologic development, stem cells turn into various tissue and bone, depending on a combination of molecular and genetic signals. (technologyreview.com)

In the technique developed at Newcastle, stem cells with XY chromosomes (male) were developed into germline stem cells which were then prompted to complete meiosis - cell division with halving of the chromosome set. (biologynews.net)
In contrast, stem cells with XX chromosomes (female) were prompted to form early stage sperm, spermatagonia, but did not progress further. (biologynews.net)
They also contained only 23 chromosomes , compared to the 46 chromosomes found in all other human cells (apart from egg cells which also contain only 23 chromosomes - when a sperm fertilises an egg they merge to form a single cell with a total of 46 chromosomes). (bionews.org.uk)
An absolute requirement for the generation of healthy offspring is the production of haploid gametes: gametes that contain half the number of chromosomes as other cells. (theconversation.com)
In the human each egg and sperm has 23 compared to all other cells which contain 46 chromosomes. (theconversation.com)
A haploid cell with 23 chromosomes (left), and a diploid cell with 46 chromosomes (right). (phys.org)
Human cells are considered 'diploid' because they inherit two sets of chromosomes, 46 in total, 23 from the mother and 23 from the father. (phys.org)
The only exceptions are reproductive (egg and sperm) cells, known as 'haploid' cells because they contain a single set of 23 chromosomes. (phys.org)
Here, using fluorescence in-situ hybridization (FISH) with arm-specific DNA probes of chromosomes 1, 2 and 5, we visualized arm domains and established hierarchical levels of sperm chromatin structures. (biologists.org)
Within this model of genome architecture in human sperm, structural organization of chromosomes remain largely unresolved. (biologists.org)
Human cells are diploid (contain a double set of chromosomes). (clinicaltrials.gov)

Patent for first method to create human sperm, but does it work? (newscientist.com)

He says that while boys don't make sperm cells, they do possess "spermatogonial" stem cells that will eventually produce them. (newscientist.com)

There is an increasing need in academic labs for higher throughput systems that allow screening across a broad spectrum of variables affecting cellular processes, and this sale validates the role of the BioFlux platform in the development of stem cell technologies for regenerative medicine. (news-medical.net)
Stem cell therapeutics firm Medistem and Superview Biotechnology signed a collaboration centered on the use of Medistem's stem cell lines to screen for monoclonal antibodies with potential in regenerative medicine. (genengnews.com)
Its lead program is centered on the use of endometrial regenerative cells (ERCs), a "universal donor"-type stem cell derived from menstrual blood. (genengnews.com)
Regenerative (reparative) medicine uses cell-based therapies to treat disease. (cnn.com)
We wrote extensively about what results in these cells - induced Pluripotent Stem Cells or iPSC - mean for stem cell research and regenerative medicine overall. (scienceblogs.com)
ProVida Clinic is a private high-level health organization which offers stem cell treatment and regenerative medicine. (placidway.com)
Given their plasticity and regenerative abilities, stem cells provide opportunities for treating human diseases such as diabetes. (cshlpress.com)
This volume is therefore an indispensable reference for molecular, cell, and developmental biologists, as well as anyone wishing to explore the possibilities of stem cells in regenerative medicine and tissue engineering. (cshlpress.com)

Spermatogonial stem cells allow men-even in their 70s-to generate sperm and father children," said Song, who also co-authored the Human Molecular Genetics study. (medicalxpress.com)
Spermatogonial stem cells allow men - even in their 70s - to generate sperm and father children. (ca.gov)
Previous efforts to generate embryonic stem cells using human egg cells had resulted in diploid stem cells. (phys.org)
It can generate enough stem cells to heal permanent wounds, especially those caused externally," she told the South China Morning Post. (cas.cn)
Nerve cells that carry electrical signals, muscle cells which generate force and pancreas cells making insulin are just a few examples. (abpischools.org.uk)

They encouraged these early-stage sperm cells, known as spermatogonial stem cells, to grow into adult sperm cells and then injected some of these into female mouse eggs. (medgadget.com)
They found some partly developed sperm cells known as spermatogonial stem cells, one of the early steps to sperm production. (thenakedscientists.com)

The original epigenetic modifications in donor cell genome are incompletely erased and abnormally reprogramed by the enucleated oocyte cytoplasm. (biomedcentral.com)
After autologous transplant, the donor genotype from lentivirus-marked SSCs was evident in the ejaculated sperm of 9/12 adult and 3/5 prepubertal recipients after they reached maturity. (elsevier.com)
Allogeneic transplant led to donor-recipient chimerism in sperm from 2/6 adult recipients. (elsevier.com)
Ejaculated sperm from one recipient transplanted with allogeneic donor SSCs were injected into 85 rhesus oocytes via intracytoplasmic sperm injection. (elsevier.com)
Over 84% of epididymal spermatozoa on the transplanted side had the donor genotype and were capable of fertilizing eggs after intracytoplasmic sperm injection forming morulae of the donor paternal origin. (elsevier.com)
Healthy stem cells from the donor (person who gives the stem cells) attack the cells of the recipient (person receiving the stem cells). (cancer.ca)

Preferred Term is Hematopoietic stem cell transplantation. (medindia.net)
In many instances, the cells lost their viability after transplantation. (cas.cn)

So the second step will be to figure out a way to make the sperm precursor cells out of induced pluripotent stem cells, or iPS cells. (latimes.com)
Moreover, it has been suggested that sAC is produced as a high-molecular-weight precursor protein that is converted to the active form by proteolytic cleavage as the sperm cells proceed through the epididymal tract ( 5 , 14 ). (pnas.org)

I think this is the best option we have ever had," says Renee Reijo Pera , director of Stanford University's Center for Human Embryonic Stem Cell Research and Education in California, who wasn't involved in the study. (newscientist.com)
The development of world's first artificial testicle for production of human sperm has been given the go ahead. (bionews.org.uk)
For starters, the recipe used to transform the mouse stem cells into sperm will need to be modified to work with human embryonic stem cells. (latimes.com)
Making spermatids in a dish from human embryonic stem cells could have important repercussions," said University of California, Irvine, biochemist Peter Donovan . (gizmodo.com.au)
It could be years before a similar feat is accomplished using human cells. (gizmodo.com.au)
It is illegal to use IVD sperm for human reproduction in the UK. (bionews.org.uk)
How soon before we can make human sperm from stem cells? (theconversation.com)
There is still a long way to go before the work can be translated to people-the main hurdle will be figuring out how to make human sperm cells from induced pluripotent stem cells , which are often taken from adult skin cells and other tissue. (discovermagazine.com)
The mouse study is published September 27 by Cell Reports and the human study was published September 15 by Human Molecular Genetics . (medicalxpress.com)
They then harvested these cells by culturing human embryonic stem cells for five days. (worldtruth.tv)
LONDON - A scientific journal has retracted a controversial paper claiming to have created the first human sperm from embryonic stem cells. (nbcnews.com)
This is the first study to characterize the changes human sperm stem cells undergo as they mature. (huntsmancancer.org)
But this first study of developing human sperm stem cells revealed this process was much more complex in humans than had been previously understood. (huntsmancancer.org)
Using single cell RNA sequencing analysis, the Cairns lab profiled cells individually, establishing the gene expression profile in human sperm stem cells. (huntsmancancer.org)
These cells, which can develop into any kind of human cell, are then nudged to become egg or sperm cells. (statnews.com)
The ethical, social, and legal conundrums surrounding stem-cell derived human gametes are vast and require close and careful consideration, not only by experts and scholars but by the public as well. (statnews.com)
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death. (the-scientist.com)
Two studies demonstrate the first direct, chemical reprogramming of mouse and human skin cells into heart muscle and neural cells. (the-scientist.com)
They have recently managed a similar feat of biological engineering, using stem cells from human adult bone marrow. (thenakedscientists.com)
A human donor's stem cell candidates-fibroblasts, typically-may be too set in their epigenetic ways to serve as the basis of new tissues and organs. (genengnews.com)
1999 - The National Bioethics Advisory Commission recommends that the government allow federal funds to be used to support research on human embryonic stem cells. (cnn.com)
The stem cells described in this paper are the first human cells that are known to be capable of cell division with just one copy of the parent cell's genome. (phys.org)
Defined sets of factors can reprogram human cells to induced pluripotent stem (iPS) cells. (phys.org)
However, many types of human cells are not easily accessible to minimally invasive procedures. (phys.org)
Pledging that his administration will "make scientific decisions based on facts, not ideology," President Obama on Monday lifted the Bush administration's strict limits on human embryonic stem cell research. (scienceblogs.com)
In making his announcement, Mr. Obama drew a strict line against human cloning, an issue that over the years has become entangled with the debate over human embryonic stem cell research. (scienceblogs.com)
Basically, the ability to reprogram the cells of any individual to a totipotent state - one in which the cells may make any cell-type or tissue in the human body. (scienceblogs.com)
Not only are ES cells inferior compared to iPSC for human therapies, but wouldn't it be easier not to upset the fundamentalists that would equate the value of our lives to that of a ball of undifferentiated cells? (scienceblogs.com)
But certainly you wouldn't equate the value of human life to that of sperm or eggs, and I don't see any rational reason why the fusion of the two is that much more special than the two on their own. (scienceblogs.com)
For instance, I was reading about research into how ES are extremely resistant to retroviral replication , who knows what other clues about human physiology and evolution we can learn from these cells that may or may not be present in iPSC. (scienceblogs.com)
Whereas recent studies demonstrated a well-defined nuclear architecture in human sperm nuclei, little is known about the mode of DNA compaction above the elementary structural unit of nucleoprotamine toroids. (biologists.org)
We propose a unified comprehensive model of chromosomal and nuclear architecture in human sperm that, as we suggest, is important for successful fertilization and early development. (biologists.org)
In this context, specific and well-organized nuclear organization recently demonstrated for human sperm cells may be of special interest. (biologists.org)
This study partially fills the noticeable gaps between our knowledge of the elementary DNA-protamine structure and the higher-order chromosome packing in human sperm cells. (biologists.org)
Human sperm cells were obtained from the semen of 10 healthy, fertile donors. (biologists.org)
There are a number of cell types present within the acinar or alveolar structures in the human. (yahoo.com)
The study, reported on line (Thursday 13 October) in Europe s leading reproductive medicine journal Human Reproduction, also looked at dichlorodiphenyldichlorethylene (DDE) - a breakdown product of DDT - but found that it did not appear to damage sperm DNA. (innovations-report.com)
They also identified five growth factors produced by testicular endothelial cells to keep human and mouse cells cultures alive for a long time. (upi.com)
After years of animal trials, the first human has been injected with cells from human embryonic stem cells, according to Geron Corporation, the company which is sponsoring the controversial study. (cnn.com)
This is the first human embryonic stem cell trial in the world,' Geron CEO Dr. Thomas Okarma tells CNN. (cnn.com)
Geron is releasing very few details about the patient, but will say that the first person to receive cells derived from human embryonic stem cells was enrolled in the FDA-approved clinical trial at the Shepherd Center, a spinal cord and brain injury rehabilitation hospital in Atlanta, Georgia. (cnn.com)
But the cells that the patient receives aren't pure human embryonic stem cells anymore. (cnn.com)
However, Okarma has previously told CNN that 'zero federal funds' were used for their human embryonic stem cell product. (cnn.com)
Much of the research supported by the Foundation cannot be funded by federal grants-in-aid because of the U.S. moratorium on funding research on human eggs activated either artificially or by sperm. (wikipedia.org)

However, the lab-grown sperm didn't appear exactly like normal sperm, and they weren't able to swim. (gizmodo.com.au)
The IVD sperm, like normal sperm, grew tails and were highly mobile. (bionews.org.uk)
They have suggested that the data, published in the journal Stem Cells and Development, is insufficient to prove the IVD sperm are equivalent to normal sperm. (bionews.org.uk)
Only one mutation was also found in a control group of men with normal sperm concentrations. (medicalxpress.com)

Based on this technique, the cells differentiated into germline stem cells. (biologynews.net)
Throughout the cell cycle, centrosomes in germline stem cells (GSCs) are oriented within their niche and this ensures asymmetric division. (nature.com)

The high expression levels observed may indicate an important role for sAC in generating cAMP in spermatozoa required for either sperm maturation, initiation of motility, hypermotility, and/or the acrosome reaction. (pnas.org)
It has, therefore, been postulated that the activation of sAC protein results in an increase of the intracellular concentration of cAMP and the induction of the signaling cascade, leading to the completion of the sperm maturation. (pnas.org)

Lab-grown sperm made from stem cells can't swim, but are able to fertilize eggs, reports Eric Boodman over at STAT . (ipscell.com)
Instead, stem cells grown in lab could be a safer bet. (cas.cn)
Amazingly, all of these cells have grown from just one single fertilised egg cell. (abpischools.org.uk)

In the most optimistic scenario our research suggests a man could have his own stem cells transplanted, giving him the opportunity to have children via natural intercourse," Orwig says. (newscientist.com)
But having the potential to become any type of cell is not the end game -- research groups around the world are trying to figure out the precise recipe for turning those stem cells into specific types of cells that would be useful for studying or treating various diseases. (latimes.com)
Interestingly, the dynamics of stem cells can be described using mathematics similar to that for ecosystem - a fruit of my beloved interdisciplinary research team! (medindia.net)
The Stem Cells Portal is a shared platform for the STEM CELLS and STEM CELLS Translational Medicine sister journals, providing up-to-the-minute coverage of the latest research from bench science and developments to clinical applications. (stemcellsportal.com)
The BBC website reports that research using stem cells to treat strokes "is set to. (nationalarchives.gov.uk)
A major focus of Dr. Karp's research is the development of stem cell based therapeutics to address tissue and organ replacement. (news-medical.net)
The BioFlux 1000 system provides our lab with high experimental throughput and reproducibility, allowing us to focus on the critical aspects of our translational research and on making targeted stem cell therapies a reality. (news-medical.net)
It's exciting to see the adoption of the BioFlux 1000 system at a world class research institution, and its use in the development of a novel application for stem cell research,' said Jeff Jensen, Chief Executive Officer at Fluxion Biosciences. (news-medical.net)
Phil Jones, MRC Cancer Cell Unit, Hutchison-MRC Research centre. (cam.ac.uk)
Stem cell research focuses on embryonic stem cells and adult stem cells. (cnn.com)
The goal of therapeutic cloning research is not to make babies, but to make embryonic stem cells, which can be harvested and used for cell-based therapies. (cnn.com)
1998 - President Bill Clinton requests a National Bioethics Advisory Commission to study the question of stem cell research. (cnn.com)
Through some scientific detective work, Wilkinson and his research team have zeroed in on a gene called RhoX10 that plays an essential role in the development of adult stem cells which give rise to sperm production. (ca.gov)
Medical News Today recently reported on research suggesting that as men age, their sperm contains more disease-causing mutations . (basilita.com)
Stem cell research: Natural Born Killers? (metafilter.com)
An interesting argument on why Bush's policy on stem cell research doesn't make sense. (metafilter.com)
Bush's policy on embryonic stem cell research is that he doesn't want it to happen. (metafilter.com)
The argument that ifs Bush truly thought stem cell research was morally wrong then why hasn't he banned it is an interesting one that slipped by me. (metafilter.com)
The consistent position would be to ban their destruction and halt current stem cell research. (metafilter.com)
The research, supported by The New York Stem Cell Foundation, the New York State Stem Cell Science Program, and by the Azrieli Foundation, underscores the importance of private philanthropy in advancing cutting-edge science. (phys.org)
The jury emphasised the exciting new vistas these cells open up for both basic and clinical research, with personalised therapies and more precisely targeted drugs," it added. (phys.org)
That is what inspired me to start my project," said Yamanaka, 48, the director of the Centre for iPS Cell Research and Application at Japan's Kyoto University. (phys.org)
Perhaps no single scientist has had a greater impact on stem cell research than Dr. Shinya Yamanaka. (phys.org)
President Obama has lifted the ban on embryonic stem cell research enacted by Bush, but I'm left feeling that this intervention came many years too late. (scienceblogs.com)
There actually is no real need for embryonic stem cell research to be extensively invested unless for some reason the iPSC don't pan out (entirely possible) or if the turn out to be different from real ES cells in some fundamental way that makes them less valuable for basic research. (scienceblogs.com)
Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease . (wikipedia.org)
In order to be used for research or treatment applications, large numbers of high-quality stem cells are needed. (wikipedia.org)
A study published today in Cell Systems highlights a new research method using the recently developed CRISPR technique. (huntsmancancer.org)
Although the hype around stem cell research has calmed down a bit in the past few years due to the economic crisis and expanded ( though contested ) federal funding, its remnants still resonate. (geneticsandsociety.org)
In 2004, Californians approved a $3 bllion bond to fund stem cell research. (geneticsandsociety.org)
The findings are published in the latest issue of the journal Cell Research . (cas.cn)
Research across the world has been trying to grow sufficient numbers of stem cells but faces problems in coaxing the cells to divide under lab conditions. (cas.cn)
In the case of muscle cells, past research has shown that the gene Pax-3 is essential in pointing stem cells down the path of muscle formation. (technologyreview.com)
The story is based on research that tested the DNA of men with unexplained low sperm counts. (www.nhs.uk)
Bedford Research Foundation is a non-profit Institute that conducts stem cell research for diseases and conditions that currently have no known cure. (wikipedia.org)
The Foundation conducts research within its own laboratories (Stem Cell, Prostate, Infectious disease) as well as in collaboration with other laboratories and raises money to award research grants to qualified investigators seeking to improve the safety and success of assisted reproduction to mothers and babies. (wikipedia.org)

However, centres in the US and Europe are already banking testicular tissue for boys in the hope that new stem-cell-based therapies will become available. (newscientist.com)
Understanding mesenchymal stem cell homing is critical to our efforts toward development of programmable stem cell therapies, but the manual approaches previously available in the lab were too slow for the large number of experiments required. (news-medical.net)
In contrast, he claims, using monoclonal antibodies to target endogenous stem cells "not only provides methods of activating stem cells but also allows for the development of stem cell adjuvant therapies that could be used to resurrect stem cell candidates that failed in clinical trials. (genengnews.com)
Our opinion is that the barriers to entry for monoclonal antibody-based therapies modulating endogenous stem cells is lower than stem cell-based therapeutics," adds Jiong Wu, Superview's CEO. (genengnews.com)
Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
In addition to the functions of the cells themselves, paracrine soluble factors produced by stem cells, known as the stem cell secretome , has been found to be another mechanism by which stem cell-based therapies mediate their effects in degenerative , auto-immune and inflammatory diseases. (wikipedia.org)
In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. (cshlpress.com)

Somatic cell nuclear transfer (SCNT) has shown a wide application in the generation of transgenic animals, protection of endangered animals, and therapeutic cloning. (biomedcentral.com)
Somatic cell nuclear transfer (SCNT) has shown great advantages and application prospects in the generation of transgenic animals, protection of endangered animals, and stem cell therapy [ 1 ]. (biomedcentral.com)
In SCNT, a somatic cell nucleus from the patient is injected into an enucleated oocyte, and the resulting ESCs are then isolated from cloned blastocysts. (biomedcentral.com)
From their work I learned that we should be able to convert somatic cells back into their embryonic state. (phys.org)

Orwig says there are some concerns that implanting stem cells could reintroduce cancer cells that may have been present in the original tissue. (newscientist.com)
These are the cells taken from skin or another adult tissue and rewound to an early state where they are flexible enough to -- say it with me -- become any type of cell in the body. (latimes.com)
To ensure a balance between the loss of differentiated cells and their replacement in long-lived multicellular organisms, it is critically important to keep the number of tissue stem cells constant. (medindia.net)
Prof. Simons said, "As a general and robust mechanism of stem cell density control, these findings may have important implications for the regulation of stem cell density in other tissue types. (medindia.net)
IVG works like this: Cells from almost any tissue or organ are reverse engineered into becoming induced pluripotent stem cells . (statnews.com)
Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. (nature.com)
A decline in stem cell function has been proposed to contribute to tissue ageing, although the underlying mechanism is poorly understood. (nature.com)
The BioFlux 1000 system can be used to study cellular interactions that are important to understanding processes such as chemotaxis, cell migration, and tissue regeneration. (news-medical.net)
As the field of personalized medicine continues to grow, this evidence necessitates further exploration into the epigenetic patterns in stem cells used for new tissue and organ generation. (genengnews.com)
One gram of tissue was used to grow about a million stem cells with the biological characteristics of beta islet cells. (blogspot.com)
The firm claims this stem cell type can differentiate into nine tissue types, produces large quantities of growth factors, and exhibits a large proliferative capacity. (genengnews.com)
Multipotent stem cells can give rise to multiple types of cells, but all within a particular tissue, organ, or physiological system. (cnn.com)
Adult stem cells are already designated for a certain organ or tissue. (cnn.com)
Some adult stem cells can be coaxed into or be reprogrammed into turning into a different type of specialized cell within the tissue type - for example, a heart stem cell can give rise to a functional heart muscle cell, but it is still unclear whether they can give rise to all different cell types of the body. (cnn.com)
The primary role of adult stem cells is to maintain and repair the tissue in which they are found. (cnn.com)

The sperm cells were able to fertilise eggs and for the first time this produced healthy, fertile offspring. (bionews.org.uk)

These are not normal bone marrow stem cells but what are known as mesenchymal stem cells, which come from a slightly different population. (thenakedscientists.com)
It is an allogenic stem therapy based on mesenchymal stem cells (MSCs) derived from the bone marrow of adult donors. (wikipedia.org)

Two hundred and ten eggs were injected with the artificially-derived sperm, 65 began to undergo cell division and seven live births resulted, with six of the animals achieving adulthood. (ivf.net)
Sperm are made from cells that undergo many stages. (medicalxpress.com)
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Stem cells have been seen to undergo mutations that could lead to tumours. (cas.cn)

The nem-1 strain contains egg-restricted and multipotent stem cells, which are both capable of differentiating into eggs but not into sperms. (readabstracts.com)
Adult stem cells are known as multipotent stem cells but they are not as flexible as embryonic stem cells do, though they can be coaxed to differentiate into lots of useful cell types. (cas.cn)

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Here, we established cell culture systems for production of functional sperm from self-renewing spermatogonial stem cells (SSCs), using zebrafish testicular hyperplasias that accumulate SSCs. (nig.ac.jp)
No stem cells, adult or embryonic, have been induced to secrete enough insulin yet to cure diabetes in humans, but we know SSCs have the potential to do what we want them to do, and we know how to improve their yield," said Dr Gallicano. (blogspot.com)

Until now, the recapitulation of all of the essential steps of meiosis has remained a major obstacle to the production of functional sperm and egg cells in a dish. (esciencenews.com)

The procedure was successfully repeated using another type of embryonic cell that was manipulated into a stem cell state. (bionews.org.uk)

These "spermatid-like cells" were used to successfully fertilise mouse egg cells and produce healthy fertile offspring. (theconversation.com)
One of the major concerns about lab-made sperm is whether or not they are genetically the same as healthy sperm produced in the body. (sciencemediacentre.co.nz)
a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
Even though the cells can be extracted from healthy muscles fairly easily, big wounds require large numbers to be removed from healthy parts of the patient's body, posing a risk. (cas.cn)

In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
It takes time for stem cells to make their way to the bone marrow and start making new blood cells (called engraftment). (cancer.ca)
The risk of infection for all types of transplant is high until the bone marrow starts to make white blood cells. (cancer.ca)

The new study, co-led by Jiahao Sha and Qi Zhou, is the first to demonstrate that it's possible to push embryonic stem cells through meiosis (cell division) to produce a functional gamete, with apparently correct nuclear DNA and chromosomal content, and the ability to produce viable offspring. (gizmodo.com.au)

Anatomy62

Organisms19

Diseases13

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology1

Phenomena and Processes57

Disciplines and Occupations4

Technology, Industry, Agriculture1

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Named Groups1

Health Care2

Epigenetics of human development

Aulacomnium palustre

Axel Kahn

ENU

Frozen zoo

Karim Nayernia

Simon Fishel

Gametogenesis

Humster

CD52

Human cloning

Spermatocytogenesis

Robert Edwards (physiologist)

Spermatogenesis

Neplodnost

Gametogenesis

Cellular differentiation

KDM1A

Dominant white

Germ line development

Good tissue practice

Contribution of epigenetic modifications to evolution

PAX7

Mosaic (genetics)

Microinjection

2006 Missouri Constitutional Amendment 2

Judith Kimble

Knockout mouse

Takehiko Ogawa

Telomerase

LMNA - 维基百科，自由的百科全书

Pinophyta

Androgen

Inbreeding

Reptile

Histone

Cilmes šūna - Vikipēdija

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Bird

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კისტური ფიბროზი - ვიკიპედია

Cryoprotectant

위키백과:모든 언어의 위키백과마다 꼭 있어야 하는 문서 목록/확장판/생물학 및 의과학 - 위키백과, 우리 모두의 백과사전

Fish fin

Genetics

Insect

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Birth defect

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X-inactivation

Stem-cell therapy

Stem cells turned into sperm | New Scientist

Sperm stem cells restore male fertility | New Scientist

Generating oocytes and sperm from embryonic stem cells. - PubMed - NCBI

Preserving sperm stem cells restores fertility in mice | National Institutes of Health (NIH)

Stem Cell Derived Sperm: It Works! | Medgadget

Artificial sperm made from stem cells - BioNews

Human sperm created from embryonic stem cells

Stem cells: Japanese scientists make sperm from embryonic stem cells derived from mice - latimes

Johns Hopkins Researchers Make Stem Cells From Developing Sperm - 08/06/2009

Stem Cells Made from Developing Sperm by Johns Hopkins Researchers

Scientists Have Created Functional Sperm From Stem Cells | Gizmodo Australia

Sperm from stem cells sparks media furore - BioNews

Novel Mechanism for Sperm Stem Cell Number Control identified

Healthy mouse sperm grown in a dish from stem cells

Worldwide First: Stem Cells Turned Into Sperm Turned Into Living Animals - 80beats : 80beats

The Testis: From Stem Cell to Sperm Function: Erwin Goldberg: Hardcover: 9780387950242: Powell's Books

stem cell scientists create embryo without egg or sperm cloning | Science | News | Express.co.uk

IVF.net - Stem cell sperm success - IVF News

Researchers find fertility genes required for sperm stem cells

Sperm derived from stem cells - Experts reaction - Science Media Centre