Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Mucin 5AC: A gel-forming mucin that is primarily found on the surface of gastric epithelium and in the RESPIRATORY TRACT. Mucin 5AC was originally identified as two distinct proteins, however a single gene encodes the protein which gives rise to the mucin 5A and mucin 5C variants.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Erigeron: A plant genus of the family ASTERACEAE that is similar to CONYZA. Members contain SESQUITERPENES.Respiratory Mucosa: The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Mucin-2: A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.Mucin-5B: A gel-forming mucin that is predominantly expressed by submucosal glands of airway tissues and the SUBLINGUAL GLAND. It is one of the principal components of high molecular weight salivary mucin.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Goblet Cells: A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.Gastric Mucins: Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.Pseudomyxoma Peritonei: A condition characterized by poorly-circumscribed gelatinous masses filled with malignant mucin-secreting cells. Forty-five percent of pseudomyxomas arise from the ovary, usually in a mucinous cystadenocarcinoma (CYSTADENOCARCINOMA, MUCINOUS), which has prognostic significance. Pseudomyxoma peritonei must be differentiated from mucinous spillage into the peritoneum by a benign mucocele of the appendix. (Segen, Dictionary of Modern Medicine, 1992)Vanadium Compounds: Inorganic compounds that contain vanadium as an integral part of the molecule.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Mucus: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Leukocyte Elastase: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Interleukin-13: A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.Lung Neoplasms: Tumors or cancer of the LUNG.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cell Line, Tumor: A cell line derived from cultured tumor cells.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Stomach Neoplasms: Tumors or cancer of the STOMACH.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Colonic Neoplasms: Tumors or cancer of the COLON.Cardia: That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Mucin-4: A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Mucin-6: A gel-forming mucin that is predominantly associated with the gastric epithelium.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Mucin-3: A membrane-bound mucin subtype that is primarily found in INTESTINAL MUCOSA. Two closely-related subtypes of this protein have been identified in humans.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Antigens, Tumor-Associated, Carbohydrate: Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Cecal Neoplasms: Tumors or cancer of the CECUM.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Rectal Neoplasms: Tumors or cancer of the RECTUM.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Adenoma: A benign epithelial tumor with a glandular organization.Sialomucins: A subcategory of mucins that contain SIALIC ACID.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Keratin-20: A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.DNA, Neoplasm: DNA present in neoplastic tissue.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Ileal Neoplasms: Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
... solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence ... The 1999 World Health Organization classification system defined MCACL as a cystic adenocarcinoma with copious mucin production ... in order of increasing relative extent of cellular mucus production and extracellular mucus accumulation - solid adenocarcinoma ... The mouse monoclonal antibody 1D3, developed to detect a high molecular weight mucin found in a number of cystic malignancies ...
It is currently considered a variant of solid adenocarcinoma with mucin production. Synonyms for FA include well differentiated ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ... fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of fetal type, and pulmonary endodermal tumour ... April 2008). "Fetal adenocarcinoma of the lung in a 25-year-old woman". J Thorac Oncol. 3 (4): 441-3. doi:10.1097/JTO. ...
To reveal the adenocarcinomatous lineage of the solid variant, demonstration of intracellular mucin production may be performed ... adenocarcinoma Micropapillary predominant adenocarcinoma Solid predominant adenocarcinoma Invasive mucinous adenocarcinoma In ... Enteric adenocarcinoma of the lung Cribriform adenocarcinoma of the lung Adenocarcinoma of the lung tends to stain mucin ... Minimally invasive adenocarcinoma of the lung Invasive adenocarcinoma Acinar predominant adenocarcinoma Papillary predominant ...
... papillary adenocarcinoma, and solid adenocarcinoma with mucin production. However, approximately 80% of adenocarcinomas are ... Atypical adenomatous hyperplasia of the lung Minimally invasive adenocarcinoma of the lung Adenocarcinoma of the lung Van Schil ... including BACs and other forms of adenocarcinoma. The Noguchi classification system for small adenocarcinomas has received ... BACs are one of four specific histologic subtypes of lung adenocarcinoma, along with acinar adenocarcinoma, ...
This is due to the over-production of many substances, including serotonin, which are released into the systemic circulation, ... Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. ... adenocarcinomas. (8140-8429). Gastrointestinal. *tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas * ... mucin stains are also helpful in identifying them. They behave in a more aggressive manner than do classical appendiceal ...
It is currently considered a variant of solid adenocarcinoma with mucin production. Synonyms for FA include well differentiated ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ... fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of fetal type, and pulmonary endodermal tumour ... April 2008). "Fetal adenocarcinoma of the lung in a 25-year-old woman". J Thorac Oncol. 3 (4): 441-3. doi:10.1097/JTO. ...
To reveal the adenocarcinomatous lineage of the solid variant, demonstration of intracellular mucin production may be performed ... adenocarcinoma Micropapillary predominant adenocarcinoma Solid predominant adenocarcinoma Invasive mucinous adenocarcinoma In ... Enteric adenocarcinoma of the lung Cribriform adenocarcinoma of the lung Adenocarcinoma of the lung tends to stain mucin ... Minimally invasive adenocarcinoma of the lung Invasive adenocarcinoma Acinar predominant adenocarcinoma Papillary predominant ...
Solid predominant with mucin production. * Variants of invasive adenocarcinoma. * Invasive mucinous adenocarcinoma ... adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma. ... American Roentgen Ray Society Images of Adenocarcinoma of the lung classification All Images. X-rays. Echo & Ultrasound. CT ... Adenocarcinoma of the lung may be classified according to WHO into mixed, acinar, papillary, bronchioloalveolar carcinoma, and ...
Adenocarcinomas are made of glands with papillary structures, or solid growth with mucin production. ... They found a better prognosis for women and adenocarcinoma, with a 67% 5-year survival for adenocarcinoma vs 53% for SCC. In ... Adenocarcinoma was more frequent than squamous cell carcinoma (SCC) in women (55% vs 25%), while the opposite was true in men ( ... Adenocarcinoma shows a growing incidence, particularly in younger nonsmoking females, whereas SCC and SCLC are on the decline.[ ...
Adenocarcinoma is the most common type of lung cancer in contemporary series, accounting for approximately (...) ... and solid predominant with mucin production.. Invasive mucinous adenocarcinoma (formerly mucinous bronchioloalveolar pattern) ... pulmonary solid adenocarcinoma pulmonary clear cell adenocarcinoma pulmonary mucinous adenocarcinoma (colloid) pulmonary ... pulmonary signet ring adenocarcinoma pulmonary mixed adenocarcinoma pulmonary fetal adenocarcinoma. * low-grade adenocarcinoma ...
anal canal adenocarcinoma 10.2. CD274 KRT7 10. solid adenocarcinoma with mucin production 10.2. KRT7 NKX2-1 ... positive regulation of production of miRNAs involved in gene silencing by miRNA. GO:1903800 8.96. EGFR TP53 ... MalaCards based summary : Pleomorphic Carcinoma is related to intestinal perforation and adenocarcinoma. An important gene ... Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the ...
solid adenocarcinoma with mucin production 10.0. MUC1 MUC5AC 44. chronic ethmoiditis 10.0. MUC1 MUC5AC ... Mucin 5AC, Oligomeric Mucus/Gel-Forming. Protein Coding. 4.49. DISEASES inferred 15 ...
Solid Predominant with Mucin Production. Variants of Invasive Lung Adenocarcinoma. *Invasive Mucinous Adenocarcinoma (Formerly ... Survival with Adenocarcinoma In Situ (AIS) or Minimally Invasive Adenocarcinoma (MIA) *5-Year Survival with Complete Resection ... Adenocarcinoma: glandular architecture, sometimes with cytoplasmic mucin which can be detected by histochemical stains ( ... Adenocarcinoma: the incidence of adenocarcinoma has increased significantly, with a corresponding decrease in other pathologic ...
The pathologic examination revealed a collision tumor consisting of a poorly differentiated adenocarcinoma of the colon and ... of the literature revealed that this is the fourth case of metastatic breast carcinoma coexisting with colonic adenocarcinoma. ... Figure 1: Poorly differentiated colonic adenocarcinoma displaying extracellular mucin production (white arrow) (HE x 100). ... Several variants have been reported in the literature besides the classical ILC, including solid, signet ring cell, ...
Most adenocarcinomas contain variable areas of clear cell change. (H) Several tumors show variable area of mucin production. ... 2E). One case showed a mainly solid pattern. Most of the adenocarcinomas accompanied clear cell changes (Fig. 2G). Clear cells ... Several areas of intracellular or extracellular mucin production (Fig. 2H) were detected. In addition, there were many foci of ... Adenocarcinoma with UIP. Seventeen of the 43 lung cancers were adenocarcinomas. Microscopically, dense fibrotic stroma and ...
Adenocarcinoma of the lung and subtypes:- Minimally Invasive, Bronchioloalveolar Carcinoma, Papillary Adenocarcinoma, Mucinous ... Other patterns include acinar, papillary, micropapillary, and solid predominant with mucin production. ... 5.4.2 Mucinous Adenocarcinomas (non-BALC type). Some invasive adenocarcinomas of the lung show abundant mucin production. These ... Colloid carcinoma of the lung is a low-grade adenocarcinoma that is associated with abundant mucin production. As this is a low ...
Solid adenocarcinoma with mucin production Fetal adenocarcinoma *Consists glandular elements: *Tubules of glycogen-rich ... Adenocarcinomas account for the majority of small peripheral cancers identified radiologically. Aerogenous spread is ... "Chapter 13, box on morphology of adenocarcinoma". Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 1-4160-2973-7 ... Adenocarcinoma of the lung. Librepathology 2015. http://librepathology.org/wiki/index.php/File:Adenocarcinoma_%283950819000%29. ...
... is a rare form of adenocarcinoma of lung (falls under invasive category). Epidemiology Some reports suggest its occurence at ~ ... solid predominant with mucin production. *variants of invasive carcinoma *invasive mucinous adenocarcinoma (formerly mucinous ... Fetal adenocarcinoma of the lung (FLAC) is a rare form of adenocarcinoma of lung (falls under invasive category). ... Fetal adenocarcinoma of the lung. Dr Bruno Di Muzio ◈ and Dr Yuranga Weerakkody ◉ et al. ...
... among which eighteen cases were solid predominant subtype with mucin production; nine cases were acinar predominant subtype; ... Adenocarcinoma/metabolism , Adenocarcinoma/secondary , Carcinoma, Non-Small-Cell Lung/metabolism , Carcinoma, Non-Small-Cell ... one case was papillary predominant subtype and three cases were invasive mucinous adenocarcinoma. The ALK + non-adenocarcinoma ... Adenocarcinoma , Drug Therapy , Genetics , Pathology , Alkaline Phosphatase , Genetics , Metabolism , Gene Fusion , Genes, erbB ...
... among which eighteen cases were solid predominant subtype with mucin production; nine cases were acinar predominant subtype; ... one case was papillary predominant subtype and three cases were invasive mucinous adenocarcinoma. The ALK + non-adenocarcinoma ... Cut surface of the tumor was typically solid with cysts formed. The histopathological changes displayed solid nests, diffuse ... Adenocarcinoma , Genetics , Pathology , Carcinoma, Adenosquamous , Genetics , Pathology , Carcinoma, Non-Small-Cell Lung , ...
2004 USCAP, Inc All rights reserved /04 $ immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma ... 34 A total of 20 were of the acinar type, five of papillary type and 10 of solid with mucin production type. The expression of ... consisted of 10 breast adenocarcinomas, two ovarian adenocarcinomas, one colon adenocarcinoma, two gastric adenocarcinomas, one ... Mucins as differentiation markers in bronchial epithelium. Squamous cell carcinoma and adenocarcinoma display similar ...
... it is a malignant tumor with glandular differentiation or mucin production expressing in different patterns and... ... Adenocarcinoma of the lung is the most common histologic type of lung cancer. Grouped under the non-small cell carcinomas of ... solid predominant adecarcinoma of lung with mucin production. *variants of invasive adenocarcinoma * invasive mucinous ... solid predominant adecarcinoma of lung with mucin production. *variants of invasive adenocarcinoma * invasive mucinous ...
Solid pancreatic tumors. Pancreatic adenocarcinoma With an estimated 43,140 new cases of pancreatic adenocarcinoma in the U.S. ... A typical finding on ERCP is the so called bulging papilla secondary to increased mucin production by the lesions. ... Solid pseudopapillary tumor (SPT). Previously known as solid-cystic papillary epithelial neoplasms (SPEN), these lesions are ... Unlike cystic lesions seen in other solid organs in the abdomen, true cysts are rare and almost never occur in a normal patient ...
papillary (fronds of tumour on thin septa), solid carcinoma with mucin production} (poorly differentiated lesions), and ... small peripheral adenocarcinoma of the lung.. Bronchioloalveolar carcinoma is a special type of adenocarcinoma. ... Adenocarcinoma of the lung is usually a peripheral tumour. Adenocarcinomas have an equal sex incidence and are not as closely ... A proportion of adenocarcinomas. are thought to originate in areas of pre-existing lung scarring (scar cancers).. There are ...
Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous ... Lung origin (adenocarcinoma) - Genitourinary origin - Gastrointestinal origin - Breast origin - Ovarian origin Table 2. ... Characterizing the cancer genome in lung adenocarcinoma.. Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, ... Adenocarcinoma - Small cell lung cancer (SCLC). - Pleural effusions of SCLC. - Pulmonary sclerosing hemangioma. - ...
ALK rearrangements and driver mutations such as EGFR and K-ras are frequently found in all types of lung adenocarcinoma. EGFR ... nGGOs with ALK rearrangements were associated with significantly higher pathologic stage and larger maximal and solid diameter ... All but one of the resected nGGOs were adenocarcinomas. ALK rearrangements and EGFR mutations were found in 6 (2.8%) and 119 ( ... The frequency of ALK rearrangement in nGGO was significantly lower than previously reported in adenocarcinoma. Advanced disease ...
extended business union Cells Targeting the core broker of the Membrane Mucin MUC1 Control Adenocarcinoma. Whilding LM, Parente ... The HER-2-targeting dictates discover and orshould hard Apply the company of production print Romans. Gianni L, Pienkowski ... for Hispanic-serving solid lack and with the highest m-d-y of Medical School. system53.com/LZQBClub/calendar transition; sent ... Targeting of Aberrant alphavbeta6 Integrin Expression in Solid Tumors obtaining Chimeric Antigen Receptor-Engineered loan Cells ...
... of the pancreas with malignant degeneration into adenocarcinoma SURGICAL AND PATHOLOGIC FINDIN... ... In our patient, the hypodense solid mass is typical of duct-cell adenocarcinoma, while the small adjacent cysts are typical for ... IPMT is characterized by intraductal cuboid or tall columnar epithelium proliferation and abundant mucin production that causes ... Small cysts were present in the pancreatic head adjacent to the solid mass. No regional lymphadenopathy or solid hepatic ...
Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous ... Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 ... Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]. Thyroid: Medullary carcinoma BAZ1A/NKX2-1 (14q13 ... Lung origin (adenocarcinoma) - Genitourinary origin - Gastrointestinal origin - Breast origin - Ovarian origin Table 2. ...
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  • The latter variant shows both intra- and extracellular mucin production, a rare feature among breast carcinomas . (cureus.com)
  • An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. (bloodjournal.org)
  • Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. (bloodjournal.org)
  • The most common histology encountered historically in this region were squamous cell carcinomas 6,7 , however, more recently, and in keeping with the overall shift in frequency, bronchogenic adenocarcinomas are now more frequently identified 8 . (radiopaedia.org)
  • Girling A, Bartkova J, Burchell J, Gendler S, Gillett C, Taylor-Papadimitriou J (1989) A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. (springer.com)
  • large cell carcinomas tend to arise peripherally and likely represent undifferentiated and highly anaplastic derivatives of squamous cell carinomas or adenocarcinomas. (pathwaymedicine.org)
  • In the absence of the obvious risk factors detailed below, bronchogenic carcinomas are exceedingly rare, although it still possible and typically manifests as the adenocarcinoma subtype. (pathwaymedicine.org)
  • Especially, prognostically less favorable entities such as salivary duct carcinomas and adenocarcinomas NOS (not otherwise specified) yielded higher expressions. (bvsalud.org)
  • Findings favoring groove pancreatitis over adenocarcinoma include cystic changes within the lesion, smooth rather than abrupt narrowing of the pancreatic and CBD, and a sheet-like mass rather than a rounded mass. (appliedradiology.com)
  • In contrast to other pancreatic cystic lesions, IPMTs are intraductal and have a marked mucin hypersecretion, which results in characteristic imaging and endoscopic appearances. (appliedradiology.com)
  • and poroid hidradenoma, which is a solid-cystic, dermal poroma. (curehunter.com)
  • Ultrasonography of right iliac fossa showed a well-defined hypoechoic cystic tubular lesion measuring 10 x 5 centimetres, with hyperechoic internal debris and no evidence of septations, solid components or surrounding inflammatory changes (Figure 1). (eurorad.org)
  • 60% arise from the head, 15% body or tail and 20% diffusely involve the whole gland They are either solid or cystic. (slidesfinder.com)
  • Malignant mucocele shows high correlation with colorectal adenocarcinoma (six times greater risk than the general population) and mucin producing ovarian & kidney tumours [1, 2, (eurorad.org)
  • Histologically, the ground-glass attenuation corresponds to a lepidic growth pattern and the solid component corresponds to invasive patterns. (radiopaedia.org)
  • In the peritoneal cavity PMP cells grow relatively slowly, but they secrete abundant amounts of extracellular mucin, which in the terminal phase of the disease causes progressive obstruction of the bowel that finally leads to death of the patient. (mcponline.org)
  • 4 Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain and 5 Department of Biochemistry and Molecular Biology, UNMC/Eppley Cancer Center, University of Nebraska Medical Center, NE, USA The distinction between pleural malignant mesothelioma and pleural infiltration by adenocarcinomas has complex therapeutic and medicolegal implications. (docplayer.net)
  • MUC4 is a membrane-bound mucin that has been suggested to be implicated in malignant progression in humans and rats. (docplayer.net)
  • We conclude that MUC4 is a very specific (100%) and sensitive (91.4%) marker of lung adenocarcinomas on paraffin-embedded tissue that could be useful in diagnostic practice in the distinction between malignant mesothelioma and adenocarcinoma. (docplayer.net)
  • 3,16 MOC-31 immunostaining is also a useful marker of lung adenocarcinomas although positive immunostaining in a limited number of cells has been described in malignant mesotheliomas. (docplayer.net)
  • The ultrasound-guided fine needle aspiration of the left breast lesion showed malignant cells consistent with intermediate to high-grade ductal adenocarcinoma with mucinous features. (healio.com)
  • Her repeat mammogram and ultrasound of bilateral breasts showed a new heterogeneous solid nodule measuring 7 mm in the sub-areolar region of the left breast at the site of palpable nodule. (healio.com)
  • Most of these markers, such as BerEP4, CD15, the thyroid transcription factor (TTF-1) and carcinoembryonic antigen (CEA) stain adenocarcinomas whereas calretinin and CK5/6 are positive in both benign Correspondence: Professor M-C Copin, Service d Anatomie et Cytologie Pathologiques, Hôpital Calmette, CHRU, Bd J. Leclercq, Lille Cedex, France. (docplayer.net)
  • The antigen was shown to be highly expressed on adenocarcinomas particularly those of gastrointestinal origin. (aacrjournals.org)
  • The trisaccharide is a precursor to the Lewis blood group antigens, but RAAG12 is distinct from those antigen structures and is not one of the previously described mucin antigens ( 3 ). (aacrjournals.org)
  • A cribriform growth pattern was identified as the dominant histologic feature, and a solid signet ring cell component was focally present in a minority of the cases. (biomedcentral.com)
  • one of our cases demonstrates a transition from a solid hidradenoma-like pattern to nests of tumour cells floating in mucin lakes, adding support for the sweat gland hypothesis. (curehunter.com)
  • Poorly differentiated adenocarcinoma will not resemble the normal glands (high grade) and will be detected by seeing that they stain positive for mucin (which the glands produce). (wikipedia.org)
  • These Il10 knock-out mice exhibit altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli, increased prevalence of colorectal adenocarcinoma, and spontaneous development of chronic enterocolitis. (jax.org)
  • Under conventional housing conditions, Il10 -deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli (both endogenous and induced), increased prevalence of colorectal adenocarcinoma (especially on 129/Sv and, to a lesser extent, BALB/c genetic background), and spontaneous development of chronic enterocolitis (see below). (jax.org)
  • Adénocarcinome Papillaire 0 questions An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. (lookformedical.com)