A mixture of alpha-chaconine and alpha-solanine, found in SOLANACEAE plants.

Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism. (1/8)

BACKGROUND: The duration of action for many pharmaceutical agents is dependent on their breakdown by endogenous hydrolytic enzymes. Dietary factors that interact with these enzyme systems may alter drug efficacy and time course. Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. Natural glycoalkaloid toxins produced by plants of the family Solanaceae, which includes potatoes and tomatoes, inhibit both AChE and BuChE. Here the authors assess the extent to which two solanaceous glycoalkaloids (SGAs), alpha-solanine and alpha-chaconine, can alter the effects of neuromuscular blocking drugs and cholinesterase inhibitors in vivo and in vitro. METHODS: Inhibition of purified human AChE and BuChE by SGAs, neuromuscular blocking drugs, and cholinesterase inhibitors was assessed by an in vitro colorimetric cholinesterase assay. In vivo experiments were carried out using anesthetized rabbits to test whether SGAs affect recovery from mivacurium-induced paralysis. RESULTS: SGAs inhibited human BuChE at concentrations similar to those found in serum of individuals who have eaten a standard serving of potatoes. Coapplication of SGAs (30-100 nm) with neuromuscular blocking drugs and cholinesterase inhibitors produced additive cholinesterase inhibition. SGA administration to anesthetized rabbits inhibited serum cholinesterase activity and mivacurium hydrolysis. In addition, SGA prolonged the time needed for recovery from mivacurium-induced paralysis (149 +/- 12% of control; n = 12). CONCLUSIONS: These findings support the hypothesis that inhibition of endogenous enzyme systems by dietary factors can influence anesthetic drug metabolism and duration of action. Diet may contribute to the wide variation in recovery time from neuromuscular blockade seen in normal, healthy individuals.  (+info)

Effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells. (2/8)

AIM: To observe the effect of solanine on the membrane potential of mitochondria in HepG(2) cells and [Ca(2+)](i) in the cells, and to uncover the mechanism by which solanine induces apoptosis. METHODS: HepG(2) cells were double stained with AO/EB, and morphological changes of the cells were observed using laser confocal scanning microscopy (LCSM). HepG(2) cells were stained with TMRE, and change in the membrane potential of mitochondria in the cells were observed using LCSM. HepG(2) cells were double stained with Fluo-3/AM, and change of [Ca(2+)](i) in the cells were observed using LCSM. HepG(2) cells were double stained with TMRE and Fluo-3/AM, and both the change in membrane potential of mitochondria and that of [Ca(2+)](i) in the cells were observed using LCSM. RESULTS: Cells in treated groups showed typical signs of apoptosis. Staining with TMRE showed that solanine could lower membrane potential; staining with Fluo-3/AM showed that solanine could increase the concentration of Ca(2+) in tumor cells; and those of double staining with TMRE and Fluo-3/AM showed that solanine could increase the concentration of Ca(2+) in the cells at the same time as it lowered the membrane potential of mitochondria. CONCLUSION: Solanine opens up the PT channels in the membrane by lowering the membrane po-tential, leading to Ca(2+) being transported down its concentration gradient, which in turn leads to the rise of the concentration of Ca(2+) in the cell, turning on the mechanism for apoptosis.  (+info)

alpha-Chaconine inhibits angiogenesis in vitro by reducing matrix metalloproteinase-2. (3/8)

alpha-Chaconine, a naturally occurring steroidal glycoalkaloid in potato sprouts, was found to possess anti-carcinogenic properties, such as inhibiting proliferation, migration, invasion, and inducing apoptosis of tumor cells. However, the effect of alpha-chaconine on tumor angiogenesis remains unclear. In the present study, we examined the effect of alpha-chaconine on angiogenesis in vitro. Data demonstrated that alpha-chaconine inhibited proliferation of bovine aortic endothelial cells (BAECs) in a dose-dependent manner. When treated with non-toxic doses of alpha-chaconine, cell migration, invasion and tube formation were markedly suppressed. Furthermore, alpha-chaconine reduced the expression and activity of matrix metalloproteinase-2 (MMP-2), which is involved in angiogenesis. Our biochemical assays indicated that alpha-chaconine potently suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), phosphatidylinositide-3 kinase (PI3K) and Akt, while it did not affect phosphorylation of extracellular signal regulating kinase (ERK) and p38. In addition, alpha-chaconine significantly increased the cytoplasmic level of inhibitors of kappaBalpha (IkappaBalpha) and decreased the nuclear level of nuclear factor kappa B (NF-kappaB), suggesting that alpha-chaconine could inhibit NF-kappaB activity. Furthermore, the treatment of inhibitors specific for JNK (SP600125), PI3K (LY294002) or NF-kappaB (pyrrolidine dithiocarbamate) to BAECs reduced tube formation. Taken together, the results suggested that alpha-chaconine inhibited migration, invasion and tube formation of BAECs by reducing MMP-2 activities, as well as JNK and PI3K/Akt signaling pathways and inhibition of NF-kappaB activity. These findings reveal a new therapeutic potential for alpha-chaconine on anti-angiogenic therapy.  (+info)

alpha-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities. (4/8)

alpha-Solanine, a naturally occurring steroidal glycoalkaloid in potato sprouts, was found to possess anti-carcinogenic properties, such as inhibiting proliferation and inducing apoptosis of tumor cells. However, the effect of alpha-solanine on cancer metastasis remains unclear. In the present study, we examined the effect of alpha-solanine on metastasis in vitro. Data demonstrated that alpha-solanine inhibited proliferation of human melanoma cell line A2058 in a dose-dependent manner. When treated with non-toxic doses of alpha-solanine, cell migration and invasion were markedly suppressed. Furthermore, alpha-solanine reduced the activity of matrix metalloproteinase-2 (MMP-2) and MMP-9, which are involved in the migration and invasion of cancer cells. Our biochemical assays indicated that alpha-solanine potently suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), phosphatidylinositide-3 kinase (PI3K) and Akt, while it did not affect phosphorylation of extracellular signal regulating kinase (ERK). In addition, alpha-solanine significantly decreased the nuclear level of nuclear factor kappa B (NF-kappaB), suggesting that alpha-solanine inhibited NF-kappaB activity. Taken together, the results suggested that alpha-solanine inhibited migration and invasion of A2058 cells by reducing MMP-2/9 activities. It also inhibited JNK and PI3K/Akt signaling pathways as well as NF-kappaB activity. These findings reveal new therapeutic potential for alpha-solanine in anti-metastatic therapy.  (+info)

Review of the inhibition of biological activities of food-related selected toxins by natural compounds. (5/8)

 (+info)

Extending the detection limit of the TDx fluorescence polarization immunoassay for benzoylecgonine in urine. (6/8)

This modified calibration method decreases from 300 to 27 micrograms/L the limit of detection for the cocaine metabolite (hydrolysis product), benzoylecgonine, by the Abbott Laboratories TDx fluorescence polarization immunoassay. For this determination we used 30 controls prepared from a single urine pool known to be negative for cocaine metabolite. Assay of 80 controls prepared from 20 different patients' urine samples yielded a limit of detection of 44 micrograms/L. To test these limits of detection, we analyzed 90 patients' urine samples known to be negative for cocaine metabolite and 74 patients' samples known to be positive for cocaine metabolite, using the TDx with our revised calibration. Results for two of the known negative samples and 96% of the samples containing cocaine in the 50 to 100 micrograms/L range fell above the 44 micrograms/L limit. The TDx showed excellent calibration stability. For 28 days during the test, the instrument was not recalibrated. During this period the day-to-day analysis of 50 micrograms/L controls produced a mean TDx response of 0.485 (SD 0.007) with a coefficient of variation of 1.5%.  (+info)

Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice. (7/8)

Reduced liver weight was used to evaluate the potential toxicity in mice of four naturally occurring steroidal glycoalkaloids: alpha-chaconine and alpha-solanine, alpha-tomatine and solasonine. Increased liver weights was used to evaluate the three corresponding steroidal aglycones: solanidine, tomatidine, and solasodine and the non-alkaloid adrenal steroid dehydroepiandrosterone (DHEA). Adult female Swiss-Webster mice were fed diets containing test compound concentrations of 0 (control), 1.2, 2.4 or 4.8 mmol/kg diet for 7, 14 or 28 d. Absolute liver weights (LW) and relative liver weights (liver weight/body weight x 100, %LW/BW) were determined at autopsy. The %LW/BW was lower than that of controls in mice fed the potato glycoalkaloid alpha-chaconine (-10%, P < or = 0.05) for 7 d with the 2.4 mmol/kg diet dose. Under these same conditions, %LW/BW was greater than that of controls in mice fed two aglycones: solanidine (27%, P < or = 0.001) and solasodine (8%, P < or = 0.01). Relative liver weight increases induced by the aglycones were determined under time and dose conditions in which differences in body weight and food consumption were not significant (2.4 mmol/kg diet for 28 d). Under these conditions, the observed %LW/BW increases relative to the controls were as follows: solanidine (32%, P < or = 0.001), solasodine (22%, P < or = 0.001) and DHEA (16%, P < or = 0.001). Solanidine, solasodine and DHEA were equally potent and were more potent than tomatidine. We also observed that the greater %LW/BW in mice fed 2.4 mmol/kg diet solasodine or solanidine for 14 d declined to near control values if they were fed control diets for another 14 d. The increase in relative liver weight induced by solanidine and solasodine is a reversible adaptive response. These findings and the apparent effects of structure on biological activity should serve as a guide for the removal of the most toxic ++compounds from plant foods. The implications of the results for food safety and health are discussed.  (+info)

Synthesis of gamma-chaconine and gamma-solanine are catalyzed in potato by two separate glycosyltransferases: UDP-glucose:solanidine glucosyltransferase and UDP-galactose:solanidine galactosyltransferase. (8/8)

UDP-glucose:solanidine glucosyltransferase and UDP-galactose:solanidine galactosyltransferase from cytosol of potato sprouts were partially separated by Sephadex G-100 and Q-Sepharose chromatographies, proving the existence of different glycosylation systems in biosynthesis of alpha-chaconine and alpha-solanine.  (+info)

Solanine is a glycoalkaloid toxin found in plants of the nightshade family, Solanaceae, which includes potatoes, tomatoes, eggplants, and peppers. It's primarily concentrated in the leaves, stems, and fruits (green potatoes and green, sprouted, or damaged potato areas), but it can also be found in lower concentrations in other parts of these plants. Solanine has a bitter taste and is produced by the plant as a defense mechanism against pests and diseases. When consumed in large amounts, solanine can cause symptoms such as gastrointestinal disturbances, nausea, diarrhea, vomiting, and neurological problems like headaches, dizziness, and confusion. In severe cases, it may lead to paralysis and even death. However, it's important to note that solanine concentrations in commonly consumed nightshade vegetables are generally low, and toxic effects are unlikely to occur from normal consumption unless the vegetables are spoiled or improperly prepared.

... has pesticidal properties, and it is one of the plant's natural defenses. Solanine was first isolated in 1820 from the ... In 1918, there were 41 cases of solanine poisoning in people who had eaten a bad crop of potatoes with 0.43 mg solanine/g ... Though fatalities from solanine poisoning are rare, there have been several notable cases of human solanine poisonings. Between ... A study found that the solanine levels in Kurfi Jyoti and Kurfi Giriraj potatoes increase solanine levels by 0.232 mg/g and ...
Fruthaler GJ (1955). "Solanine poisoning". Ochsner Clinic Reports. 1 (2): 50-52. Patil CD, Patil SV, Salunke BK, Salunkhe RB ( ... A solanine alkaloid isolated from the stool was hemolytic to human erythrocytes. " Plant extracts have shown larvicidal ... All members of the family Solanaceae contain an alkaloid toxin called solanine, though some members of the family are routinely ... What is solanine. Wisegeek "Night blooming jessamine (Cestrum nocturnum) , Queensland Poisons Information Centre". 18 July 2017 ...
The symptoms of acute tomatine poisoning in animals are similar to the symptoms of poisoning by solanine, a potato ... Generally, tomatine is regarded to cause less toxic effects to mammals than other alkaloids such as solanine. The human ... Tomatine is sometimes confused with the glycoalkaloid solanine. Tomatoes were brought to Europe in the early 1500s. The English ... Solanine Chaconine EBI Web Team. "tomatine (CHEBI:9630)". 1.http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+ ...
"Solanine poisoning - how does it happen?". 7 February 2014. Retrieved 24 September 2018. "Microgreens and Sprouts Are Not the ... These sprouts contain toxic alkaloids such as solanine and tropanes, which can cause adverse symptoms in the digestive and ...
The poison in this species is believed to be solanine. The alkaloids, solanine (from unripe fruits), solasodine (from flowers) ... R. F. Alexander; G. B. Forbes & E. S. Hawkins (1948-09-11). "A Fatal Case of Solanine Poisoning". Br Med J. 2 (4575): 518. doi: ... Solanine and solasodine extracted from Solanum dulcamara showed antidermatophytic activity against Chrysosporium indicum, ...
"Solanine - National Library of Medicine HSDB Database". toxnet.nlm.nih.gov. Frank T. Sanders, ed. (August 2006). Reregistration ...
1947) Puccinia solanina Speg. (1912) Puccinia solanita (Schwein.) Arthur (1922) Puccinia solani-tristis Henn. (1896) Puccinia ...
Solanine is a related substance that has similar properties. These are similar to symptoms from ingesting solanine. There are a ... chaconine had a greater effect than solanine. However, a mixture of chaconine and solanine had a synergistic effect. The ... The result showed how the amount of both α-chaconine and α-solanine did not change significantly if it is kept in a cold and ... On average, it is between 1.2 and 2.6 to 1, meaning the amount of ɑ-chaconine is greater than ɑ-solanine. However, the average ...
Solanine levels in S. nigrum have been tested, and the plant is rarely fatal. Solanine poisoning symptoms may occur when ... Solanine is water-soluble and is destroyed by boiling. S. nigrum leaves may be different from this perspective. Young cooked ... Lv, C.; Kong, H.; Dong, G.; Liu, L.; Tong, K.; Sun, H.; Zhou, M. (2014). "Antitumor efficacy of α-solanine against pancreatic ... The active ingredient of the plant, solanine, inhibits the proliferation of different cancer cells in vitro, such as breast ...
However, solanine concentrations in foliage and green fruit are generally too small to be dangerous unless large amounts are ... Compared to potatoes, the amount of solanine in unripe green or fully ripe tomatoes is low. However, even in the case of ... They also contain small amounts of solanine, a toxic alkaloid found in potato leaves and other plants in the nightshade family ... "Executive Summary Chaconine and Solanine: 6.0 through 8.0" (PDF). NIH. Archived from the original (PDF) on 28 September 2014. ...
Toxicity is from Solanine and glycol-alkaloids, chaconine, and solasodine. There is no antidote for Solanum poisoning. Symptoms ...
A very similar approach can produce 16-DPA from solanine. Progesterone can also be made from the stigmasterol found in soybean ...
These berries contain high levels of the poisonous alkaloid solanine. The species name aculeastrum refers to the thorns that ...
This is via high levels of the glycoalkaloids, solanine and solamargine. Other toxins present in the plant include chaconine, ...
New potato varieties are often screened for solanine levels before reaching the marketplace.[citation needed] Even with the ... for example the poison solanine was unintentionally increased to unacceptable levels in certain varieties of potato through ...
He found an ideal topic in the elucidation of the structure of solanine; he continued his work on Cinchona alkaloids and ...
2013 they find several BSGs for α-tomatine in tomato and α-solanine in potato. Typically they are used in plants as a ... Alkaloids found in these plants include chaconine, solanine, solasodine, tomatidine, tomatine, and solanidine. The Itkin group ...
Kuiper-Goodman, T., Nawrot, P.S., Solanine and Chaconine, IPCS Inchem Harvey, M.H.; McMillan, M.; Morgan, M.R.A.; Chan, H. W. S ... Human ingestion of solanidine also occurs via the consumption of the glycoalkaloids, α-solanine and α-chaconine, present in ...
ISBN 978-1-879906-54-9. Barceloux DG (June 2009). "Potatoes, Tomatoes, and Solanine Toxicity (Solanum tuberosum L., Solanum ...
Donald G. Barceloux (June 2009). "Potatoes, Tomatoes, and Solanine Toxicity (Solanum tuberosum L., Solanum lycopersicum L.)". ...
For instance, potatoes and tomatoes can contain toxic levels of respectively, solanine and alpha-tomatine alkaloids. To decide ...
... es contain toxic compounds known as glycoalkaloids, of which the most prevalent are solanine and chaconine. Solanine is ... Since exposure to light leads to an undesirable greening of the skins and the development of solanine as a protection from the ... Like all parts of the plant except the tubers, the fruit contain the toxic alkaloid solanine and are therefore unsuitable for ... analysis has shown solanine levels may be as little as 3.5% of the breeders' maximum, with 7-187 mg/kg (0.00011-0.00299 oz/lb) ...
A number of Solanum species contain significant levels of solanine and as such are highly poisonous. It is strongly recommended ...
All parts of the plant, and especially the fruit, are toxic, containing solanine when it matures.[citation needed] The tubers ... in which the primary glycoalkaloids are solanine and chaconine." USDA, NRCS (n.d.). "Solanum jamesii". The PLANTS Database ( ...
The tubers grow just below the surface, and can produce chlorophyll and solanine if exposed to light (green potatoes). Solanine ...
The flowers and leaves can be poisonous if consumed in large quantities due to the presence of solanine. The eggplant has a ...
Solanine has occasionally been responsible for poisonings in people who ate berries from species such as Solanum nigrum or ... Some of the main types of alkaloids are: Solanine: A toxic glycoalkaloid with a bitter taste, it has the formula C45H73NO15. It ... Solanine and Chaconine. Review of Toxicological Literature. Integrated Laboratory Systems, USA."Archived copy" (PDF). Archived ... Alexander RF, Forbes GB, Hawkins ES (1948-09-11). "A Fatal Case of Solanine Poisoning". Br Med J. 2 (4575): 518. doi:10.1136/ ...
... such as solanine. Although the toxin is poisonous, it is generally not life-threatening to humans. It may cause gastric ...
A prototypical glycoalkaloid is solanine (composed of the sugar solanose and the alkaloid solanidine), which is found in the ...
Some macrobiotic practitioners also discourage the use of nightshades because of the alkaloid solanine which is thought to ...
Solanine has pesticidal properties, and it is one of the plants natural defenses. Solanine was first isolated in 1820 from the ... In 1918, there were 41 cases of solanine poisoning in people who had eaten a bad crop of potatoes with 0.43 mg solanine/g ... Though fatalities from solanine poisoning are rare, there have been several notable cases of human solanine poisonings. Between ... A study found that the solanine levels in Kurfi Jyoti and Kurfi Giriraj potatoes increase solanine levels by 0.232 mg/g and ...
Would the solanine content be minimised if I select only tomatoes that are very ripe? In other words, does the solanine content ... Higher solanine can also result from damage during harvesting or transport. Cooking does not destroy solanine. ... Solanine is a glycol-alkaloid compound and is present in all parts of the plant. It is a bitter tasting and toxic even in small ... But for cats, even the solanine in ripe tomatoes is harmful.. In most cases, tomatoes ripened on the bush have lower levels of ...
Tag Archives: solanine. Play it Safe with Potatoes Potatoes can be prepared in many ways, which makes them one of the most ... Keep potatoes away from light during storage - even indoor lighting can cause stress for potatoes and increase toxic solanine ... solanine, Solanum tuberosum L. on November 13, 2019. by UF/IFAS Extension Leon County. ... solanine in particular - begin to increase to higher levels, becoming toxic and very dangerous if consumed. Potatoes exposed to ...
... 15 Great Human Foods Cats Can Eat To Be Healthy At Their Best. December 23, 2021. February 1, 2021. by ... solanine in potatoes, spinach, sweet potatoes, treats, vitamins, watermelon for cats, xylitol, yogourt for cats. ...
Solanine Toxicity and its Risks. Solanine is a natural toxin found in plants of the nightshade family, including tomatoes, ... For dogs, the effects of solanine toxicity can be similar.. When dogs consume large amounts of solanine, they may experience ... One of the primary concerns is solanine toxicity, as tomatoes belong to the nightshade family, which contains solanine, a ... Other signs of solanine toxicity in dogs can include drooling, weakness, tremors, dilated pupils, and in severe cases, seizures ...
Plants have evolved highly complex systems of defense against most of their natural enemies (eg, insects, animals). At the very least, these defenses make many plants unpalatable; however, some can be fatal to the inexperienced forager.
RE: ESTER Cat of the Day - POTATO PEELS ARE TOXIC TO CATS!!! They are full of are full of glycoalkaloid solanine by jdstansel * ... RE: ESTER Cat of the Day - POTATO PEELS ARE TOXIC TO CATS!!! They are full of are full of glycoalkaloid solanine 07-09-2021 09: ... Potato peels, just like raw potatoes, are full of glycoalkaloid solanine that is toxic to cats. Whats more, peels are covered ...
RE: ESTER Cat of the Day - POTATO PEELS ARE TOXIC TO CATS!!! They are full of are full of glycoalkaloid solanine by jdstansel * ... RE: ESTER Cat of the Day - POTATO PEELS ARE TOXIC TO CATS!!! They are full of are full of glycoalkaloid solanine 07-09-2021 10: ... Potato peels, just like raw potatoes, are full of glycoalkaloid solanine that is toxic to cats. Whats more, peels are covered ...
Potato plant poisoning occurs when someone eats the green tubers or new sprouts of the potato plant.
Solanine develops in potatoes when spuds are subjected to light or either very cold or very warm temperatures. The toxin ... A glycoalkaloid poison found in species of the nightshade, solanine is a nerve toxin produced in the green part of the potato ( ... The potato - or, rather, green versions of it - contains a natural toxin called solanine. The greenish hue that should warn you ... You are unlikely to ingest enough solanine from eating green potatoes to do you any serious harm. ...
Potatoes contain solanine; the highest concentration is in the sprouts.. Bacteria Induced Poison (04:22). Weigh the risks ...
Solanine and chaconine in potatoes used in Africa to treat HIV. Home Exposures ...
Two tri-glycosylated alkaloids, alpha-chaconine and alpha-solanine accumulate in potato tubers. A new sterol alkaloid ... in some of the antisense lines showing large reductions in alpha-chaconine usually compensated by an increase alpha-solanine. ...
Nightshade plants contain poisons, one called solanine. While ingesting nightshade plants can be fatal, fruits and vegetables ...
You shouldnt eat the sprouts because they contain solanine, chaconine, and other toxic glycoalkaloids. These compounds can ...
Potatoes that are exposed to the sun for too long will develop a toxin called solanine and turn green in color. Solanine makes ... Remember, leaving potatoes in the sun can cause them to turn green and develop the toxin solanine. ...
Its bright yellow-to-red berries contain solanine. When ingested, solanine causes vomiting and diarrhea, slows the heart, ...
Potatoes contain solanine, a toxin that is harmful at high levels. Only a few types of mushrooms are fit for human consumption ...
CHINESE LANTERN (Physalis spp.); unripe berries; gastrointestinal tract affect by solanine glycoalkaloids.. CHIVES (Allium spp ... suckers: gastrointestinal tract affected by solanine glycoalkaloids.. Toxicodendron spp. (POISON IVY, POISON OAK, POISON SUMAC ... BUFFALO BUR (Solanum sp.); immature growths; gastrointestinal tract affected by solanine glycoalkaloids; plant may contain ... BULL NETTLE (Solanum sp.); immature growths; gastrointestinal tract affected by solanine glycoalkaloids; plant may contain ...
Potatoes contain solanine, arsenic, and chaconine. Lima beans contain hydrogen cyanide, a classic suicide substance. Carrots ...
Algúns experimentos indican que a solanina da planta inhibe o crecemento do carcinoma cervical en ratos.[42] O seu mecanismo ... Comprobáronse os niveis de solanina en S. nigrum e a planta raramente é mortal.[9] ... Os síntomas de envelenamento por solanina poden aparecer cando se inxiren crus os froitos verdes inmaturos (parecidos a ... A solanina non é hidrosoluble e destrúese coa cocción.[11] As follas de S. nigrum poden ser diferentes desde esta perspectiva. ...
A member of the nightshade family Solanaceae, it contains toxins including solanine (as do many other fruits and veggies). ...
Solanine is one of the compounds that give potatoes their taste. In high amounts, however, solanine has a bitter taste and can ... Along with "greening" or sprouting, a compound called "solanine" forms. ...
The solanine they contain makes them mildly poisonous to humans. Grow sprouts in a jar. Whether radish, chickpea, mung bean or ...
Re: Solanine in our Thyroids?! by Whispering Wind 12 years ago 4,528 ...
Chlorophyll will turn the tuber green, but solanine will give potatoes a bitter taste, and can cause illness if eaten in large ... Dark: Exposure to light and stress will trigger chlorophyll production, forming solanine. ...
Solanine. Solanine is a poison found in potatoes. It is a natural fungicide and pesticide which develops when potatoes are ... Even cooking will not get rid of solanine at this stage and in severe cases, it will cause hallucinations, paralysis, fever and ...
Structural effects of the Solanum steroids solasodine, diosgenin and solanine on human erythrocytes and molecular models of ... This report presents evidence that the following Solanum steroids: solasodine, diosgenin and solanine interact with human ...
Constance J. Solanina, Pittsburgh, PA 15237 Constance Solano, Kings Park, NY 11754 ...
Spotting any green on the skin of the potato is a sure indication of the presence of solanine. Most commercially available ... and people have died from ingesting potato solanine. While cooking can reduce the level, every potato you eat gives you at ... particularly one nasty strain called solanine. This poison is the potatos defense mechanism that keep it from getting eaten, ...
  • Green potatoes contain a natural toxin called solanine. (snopes.com)
  • The potato - or, rather, green versions of it - contains a natural toxin called solanine. (snopes.com)
  • This is because tomatoes naturally produce a toxin called solanine. (onteenstoday.com)
  • That said, nightshade plants have high levels of a toxin called solanine . (gardeningknowhow.com)
  • Green parts of potatoes contain a natural toxin called solanine and should not be eaten. (miraclegro.com)
  • Nightshade plants contain a poisonous chemical called solanine. (thedodo.com)
  • The main reason why eating a spoiled potato is so dangerous is because they contain a chemical called solanine. (beinghuman.org)
  • The well known natural therapist, Andrew Weil, points out that there hasn't been a single case of solanine poisoning in the US from potatoes in the last 50 years. (health.org.au)
  • In the case of solanine toxicity from tomatoes, if your dog were to experience adverse effects and require veterinary care, it's important to know if your insurance policy covers such incidents. (abestfashion.com)
  • The tomato plant can cause solanine toxicity in dogs, which can be fatal. (bustle.com)
  • Potato peels, just like raw potatoes, are full of glycoalkaloid solanine that is toxic to cats. (petoftheday.com)
  • All parts of the plant contain toxic glycoalkaloid solanine and may cause gastrointestinal problems if ingested. (pestweb.com)
  • Potatoes naturally produce solanine and chaconine, a related glycol-alkaloid, as a defence against pests. (health.org.au)
  • Two tri-glycosylated alkaloids, alpha-chaconine and alpha-solanine accumulate in potato tubers. (usda.gov)
  • However, the profiles of component SGAs were altered in some of the antisense lines showing large reductions in alpha-chaconine usually compensated by an increase alpha-solanine. (usda.gov)
  • You shouldn't eat the sprouts because they contain solanine, chaconine, and other toxic glycoalkaloids. (healthline.com)
  • Other studies have found that neural tube defects in hamsters may be caused by the solanidine triglycosides, alpha-chaconine and high-dose solanine. (family-health-information.com)
  • Would the solanine content be minimised if I select only tomatoes that are very ripe? (health.org.au)
  • The short answer is that solanine is at its highest levels in green tomatoes - as it is in green potatoes - and decreases to its minimum levels in dead ripe fruit. (health.org.au)
  • So, yes, your best chance of avoiding irritation from solanine is to consume only perfectly-ripe tomatoes. (health.org.au)
  • Most plants contain natural pesticides, and solanine is the one in tomatoes. (health.org.au)
  • In potatoes, the parts which have turned green have the highest levels of solanine, which are much greater and more harmful than the solanine in tomatoes. (health.org.au)
  • In tomatoes, the highest level of the solanine group of chemicals, called tomatine, occurs when they are immature and green. (health.org.au)
  • The concentration can be up to 500 mg per 1 kg of fruit, according to the website https://www.ehow.com/info_8738165_solanine-ripe-vs-green-tomatoes.html. (health.org.au)
  • But for cats, even the solanine in ripe tomatoes is harmful. (health.org.au)
  • In most cases, tomatoes ripened on the bush have lower levels of solanine than greenhouse tomatoes because the latter have often been harvested green. (health.org.au)
  • Children and adults with tomato allergies and sensitivity are the most affected by the solanine in green tomatoes. (health.org.au)
  • One of the primary concerns is solanine toxicity, as tomatoes belong to the nightshade family, which contains solanine, a potentially harmful substance for dogs. (abestfashion.com)
  • In this article, we will explore the topic of whether dogs can eat tomatoes, the risks associated with solanine toxicity, and how it relates to insurance considerations for pet owners. (abestfashion.com)
  • While tomatoes themselves are not toxic to dogs, the plant's stems, leaves, and unripe green tomatoes contain higher levels of solanine, which can be harmful to dogs if ingested in large quantities. (abestfashion.com)
  • Some dogs may have a sensitive digestive system or be more prone to solanine toxicity, while others may tolerate tomatoes without any issues. (abestfashion.com)
  • Solanine is a natural toxin found in plants of the nightshade family, including tomatoes, potatoes, and eggplants. (abestfashion.com)
  • Tomatoes technically contain tomatine instead of solanine, which is essentially a less toxic version of that chemical. (thedodo.com)
  • The fruits of nightshade plants-potatoes, tomatoes, peppers and eggplants-generally contain very low levels of solanine, which is why they are safe to eat. (diettogo.com)
  • Some people are highly sensitive to solanine and for these folks, eating tomatoes and peppers can cause swelling and pain in the joints. (diettogo.com)
  • High concentrations of solanine are necessary to cause death to mammals. (wikipedia.org)
  • The greenish hue that should warn you away from such spuds is actually chlorophyll, but its presence indicates concentrations of solanine are present in the tuber. (snopes.com)
  • Concentrations of 38 to 45 mg/100 g solanine have been found in potatoes implicated in human fatalities, compared to 3 to 66 mg/100 g in fresh, healthy potatoes. (family-health-information.com)
  • Plants, leaves and stems, contain a poison called solanine which causes severe gastrointestinal problems. (hartz.com)
  • The presence of solanine in the leaves and stems of nightshade plants acts as a natural pesticide, dispatching any bugs that nibble too freely on the plant. (diettogo.com)
  • Ingestion of solanine in moderate amounts can cause death. (wikipedia.org)
  • When dogs consume large amounts of solanine, they may experience symptoms such as gastrointestinal distress, including vomiting and diarrhea. (abestfashion.com)
  • At least one of these substances, solanine, is toxic to humans in large amounts. (botanicalinterests.com)
  • All of these plants produce a compound called solanine that, when consumed in sufficient amounts, acts as a nerve poison. (diettogo.com)
  • If a potato is green or sprouted, it's a sign that it contains solanine, a compound that is toxic even in small amounts. (losethebackpain.com)
  • When the plant's stem, tubers, or leaves are exposed to sunlight, it stimulates the biosynthesis of solanine and other glycoalkaloids as a defense mechanism so it is not eaten. (wikipedia.org)
  • Solanine is a glycoalkaloid poison found in species of the nightshade family within the genus Solanum, such as the potato (Solanum tuberosum), the tomato (Solanum lycopersicum), and the eggplant (Solanum melongena). (wikipedia.org)
  • Potato, tomato, and eggplant glycoalkaloids like solanine have also been shown to affect active transport of sodium across cell membranes. (wikipedia.org)
  • Plants like the potato and tomato constantly synthesize low levels of glycoalkaloids like solanine. (wikipedia.org)
  • I eat a lot of tomato, which I know can aggravate arthritis due to the solanine content. (health.org.au)
  • The softer and sweeter the ripe tomato, the less solanine it contains. (health.org.au)
  • And even though you're a lot bigger than that bug, the amount of solanine in potato or tomato leaves might be enough to give you an upset stomach, which is why we don't eat those parts of the plant. (diettogo.com)
  • When ingested, solanine causes vomiting and diarrhea, slows the heart, lowers blood pressure, depresses breathing and induces coma. (vanderbilt.edu)
  • Solanine is a glycoalkaloid poison created by various plants in the genus Solanum, such as the potato plant. (wikipedia.org)
  • A glycoalkaloid poison found in species of the nightshade, solanine is a nerve toxin produced in the green part of the potato (the leaves, the stem, and any green spots on the skin). (snopes.com)
  • Symptoms usually occur 8 to 12 hours after ingestion, but may occur as rapidly as 10 minutes after eating high-solanine foods. (wikipedia.org)
  • Some studies show a correlation between the consumption of potatoes suffering from late blight (which increases solanine and other glycoalkaloid levels) and the incidence of spina bifida in humans. (wikipedia.org)
  • There are several proposed mechanisms of how solanine causes toxicity in humans, but the true mechanism of action is not well understood. (wikipedia.org)
  • In humans, solanine toxicity can cause gastrointestinal upset, headache, and even neurological symptoms in severe cases. (abestfashion.com)
  • This cell membrane disruption is likely the cause of many of the symptoms of solanine toxicity, including burning sensations in the mouth, nausea, vomiting, abdominal cramps, diarrhea, internal hemorrhaging, and stomach lesions. (wikipedia.org)
  • The solanum glycosides, such as solanine, produce gastrointestinal disturbances including nausea, vomiting, diarrhea and hemolytic and hemorrhagic damage to the gastrointestinal tract. (family-health-information.com)
  • Solanine is a glycol-alkaloid compound and is present in all parts of the plant. (health.org.au)
  • Experiments show that solanine exposure opens the potassium channels of mitochondria, increasing their membrane potential. (wikipedia.org)
  • Under stressful pre and/or post-harvest conditions (including temperature, humidity, storage time, physical injury, and exposure to light) glycoalkaloids - solanine in particular - begin to increase to higher levels, becoming toxic and very dangerous if consumed. (tallahassee.com)
  • This discoloration is called "solanine" and is caused by exposure to light. (1859oregonmagazine.com)
  • However, it is known that in the biosynthesis of solanine, cholesterol is first converted into the steroidal alkaloid solanidine. (wikipedia.org)
  • The solanidine is then converted into solanine through a series of glycosylation reactions catalyzed by specific glycosyltransferases. (wikipedia.org)
  • Another concern is that levels of naturally occurring toxins, such as solanine, might be increased in GM versions of plants. (cspinet.org)
  • The largest concentration of solanine in response to stress is on the surface in the peel, making it an even better defense mechanism against pests trying to consume it. (wikipedia.org)
  • Solanine was first isolated in 1820 from the berries of the European black nightshade (Solanum nigrum), after which it was named. (wikipedia.org)
  • However, under stress, such as the presence of a pest or herbivore, they increase the synthesis of compounds like solanine as a natural chemical defense. (wikipedia.org)
  • Toxicity typically occurs when people ingest potatoes containing high levels of solanine. (wikipedia.org)
  • The gastrointestinal tract cannot efficiently absorb solanine, which helps decrease its strength to the mammal body. (wikipedia.org)
  • In other words, does the solanine content decrease with the ripening of the fruit? (health.org.au)
  • Solanine has pesticidal properties, and it is one of the plant's natural defenses. (wikipedia.org)
  • The green colour is chlorophyll, which is harmless, but is an indication of a high solanine level. (health.org.au)
  • You are unlikely to ingest enough solanine from eating green potatoes to do you any serious harm. (snopes.com)
  • Even though human fatalities due to the consumption of green potatoes have been reported periodically, proof that solanine was the causal agent has not been firmly established. (family-health-information.com)