A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Tumors or cancer of the SKIN.
The design or construction of objects greatly reduced in scale.
Data processing largely performed by automatic means.
The theory that the radiation and absorption of energy take place in definite quantities called quanta (E) which vary in size and are defined by the equation E=hv in which h is Planck's constant and v is the frequency of the radiation.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
A publication issued at stated, more or less regular, intervals.
Remembrance of information for a few seconds to hours.
An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Proteins obtained from species in the class of AMPHIBIANS.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Substances that reduce the growth or reproduction of BACTERIA.
Infections with bacteria of the genus STAPHYLOCOCCUS.
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Common name for FISHES belonging to the order Perciformes and occurring in three different families.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
A moderate-growing, photochromogenic species found in aquariums, diseased fish, and swimming pools. It is the cause of cutaneous lesions and granulomas (swimming pool granuloma) in humans. (Dorland, 28th ed)
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
Venoms from animals of the order Scorpionida of the class Arachnida. They contain neuro- and hemotoxins, enzymes, and various other factors that may release acetylcholine and catecholamines from nerve endings. Of the several protein toxins that have been characterized, most are immunogenic.
The effects, both local and systemic, caused by the bite of SCORPIONS.
Flies of the species Musca domestica (family MUSCIDAE), which infest human habitations throughout the world and often act as carriers of pathogenic organisms.
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
A structurally-related family of small proteins that form a stable tertiary fold pattern which is supported by a series of disulfide bonds. The arrangement of disulfide bonds between the CYSTEINE moieties results in a knotted structure which is unique to this family of proteins.
Activities in which participants learn self-defense mainly through the use of hand-to-hand combat. Judo involves throwing an opponent to the ground while karate (which includes kung fu and tae kwon do) involves kicking and punching an opponent.
A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A state in southeastern Australia, the southernmost state. Its capital is Melbourne. It was discovered in 1770 by Captain Cook and first settled by immigrants from Tasmania. In 1851 it was separated from New South Wales as a separate colony. Self-government was introduced in 1851; it became a state in 1901. It was named for Queen Victoria in 1851. (From Webster's New Geographical Dictionary, 1988, p1295 & Room, Brewer's Dictionary of Names, p574)
Antimicrobial cationic peptides with a highly conserved amino terminal cathelin-like domain and a more variable carboxy terminal domain. They are initially synthesized as preproproteins and then cleaved. They are expressed in many tissues of humans and localized to EPITHELIAL CELLS. They kill nonviral pathogens by forming pores in membranes.
In 1986 he discovered magainins, a family of antimicrobial peptides in the skin of the African clawed frog. Magainin ... Magainin eventually went public and its name was changed to Genaera. The company attempted to develop squalamine, trodusquemine ... Zasloff left Penn in 1992 and joined Magainin full time. He was with the company until its lead product, pexiganan, was ... Conlon, JM; Mechkarska, M; King, JD (1 May 2012). "Host-defense peptides in skin secretions of African clawed frogs ( ...
A number of these defence peptides are secreted from the skin of frogs and other amphibians, including the opiate-like ... dermorphins and deltorphins, and antimicrobial dermaseptins, temporins, bombinins, magainin, pseudin, bombesins, and maculatins ... Conlon JM, Kolodziejek J, Nowotny N (August 2009). "Antimicrobial peptides from the skins of North American frogs". Biochimica ...
Interviewed in 1987, Zasloff explained: "I used it because it came from the skin and it was shielding, in my opinion. What the ... Magainin Pharmaceuticals (subsequently called Genaera) to develop magainins into drugs. One candidate was an analog of magainin ... Magainins at the US National Library of Medicine Medical Subject Headings (MeSH) Conlon JM, Mechkarska M, King JD (May 2012). " ... The magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). The peptides are ...
... amphibian/skin peptides, venom peptides, cancer/anticancer peptides, vaccine peptides , immune/inflammatory peptides, brain ... Magainin family. *Cecropin family. *Cathelicidin family. *Defensin family. Tachykinin peptides[edit]. Main article: Tachykinin ...
Magainin family Cecropin family Cathelicidin family Defensin family Substance P Kassinin Neurokinin A Eledoisin Neurokinin B ... amphibian/skin peptides, venom peptides, cancer/anticancer peptides, vaccine peptides, immune/inflammatory peptides, brain ...
Magainin and defensin are natural peptides, short polymers composed of amino acids, which display exceptional antimicrobial ... Quaternary ammonium cellulose derivatives are of particular interest as conditioners in hair and skin products. The field of ... Protein-mimicking polymers emulate the structure of magainin and defensin. Examples of protein mimicking polymers include poly( ... blending were prepared to use as an antimicrobial wound dressing.Cellulose derivatives are commonly used in cosmetics as skin ...
... secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. It is also ... antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in ...
"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea". Nature Medicine. 13 (8): 975-80. ... "Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease". Annals of Dermatology. 24 (2): 126-35 ...
Interviewed in 1987, Zasloff explained: "I used it because it came from the skin and it was shielding, in my opinion. What the ... Magainin Pharmaceuticals (subsequently called Genaera) to develop magainins into drugs. One candidate was an analog of magainin ... Magainins at the US National Library of Medicine Medical Subject Headings (MeSH) Conlon JM, Mechkarska M, King JD (May 2012). " ... The magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). The peptides are ...
magainin. , PGLa. , procaerulein-derived, and proxenopsin-derived peptides from skin. secretions of the octoploid frog Xenopus ...
When magainins were administered to children with impetigo, a skin infection, the cure rate of 80% was equal to that of a ... Intrigued, Zasloff analyzed the frogs skin. He discovered antibiotics that he named magainins, after the Hebrew word for ... magainins kill not only bacteria but also fungi, protozoa, and some cancer cells; Magainin researchers have successfully used ... Magainins stock sank almost 60% on the news. The FDA is allowing the company to proceed with a more significant trial, against ...
magainin. antimicrobial peptide genes in the developing granular glands of Xenopus skin. and induction by thyroid. hormone., ... skin. antigen molecule recognized by adult T cells of Xenopus laevis: Regulation by thyroid. hormone during metamorphosis., ... skin. during anuran metamorphosis., Kobayashi H, Sato H, Yoshizato K., J Exp Zool. February 15, 1996; 274 (3): 187-92.. ...
A peptide called magainin, first found in the skin of the African clawed frog, holds the secret to creating bacteria-killing ... "Like magainin, the modified arylamide polymer can disrupt the cell membranes of bacteria without harming the membranes of other ... "Our original approach was to replace the peptide backbone found in magainin with one of arylamide, which is relatively easy to ... The key to both magainin and the arylamide polymers is that they are amphiphilic - one side attracts water while the other ...
In 1986 he discovered magainins, a family of antimicrobial peptides in the skin of the African clawed frog. Magainin ... Magainin eventually went public and its name was changed to Genaera. The company attempted to develop squalamine, trodusquemine ... Zasloff left Penn in 1992 and joined Magainin full time. He was with the company until its lead product, pexiganan, was ... Conlon, JM; Mechkarska, M; King, JD (1 May 2012). "Host-defense peptides in skin secretions of African clawed frogs ( ...
M. Zasloff, "Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, ... The first amphibian skin antimicrobial peptide (AMP) to be identified was named bombinin, reflecting its origin from the skin ... One of the archetypal families of amphibian skin AMPs is the bombinins, originally discovered in the skin of Bombina variegata ... H. V. Westerhoff, M. Zasloff, J. L. Rosner et al., "Functional synergism of the magainins PGLa and magainin-2 in Escherichia ...
Magainin 1 peptide, Xenopus View Synonyms. View Structure. Description:. From skin of Xenopus laevis; 23-amino acid peptide; ... differs from magainin 2 by substitution of Gly instead of Lys at position 10 & Lys instead of Asn at position 22; also used to ...
Zasloff, M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, ... Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis. FEBS Lett. ... Bechinger, B., Zasloff, M. & Opella, S. J. Structure and orientation of the antibiotic peptide magainin in membranes by solid- ... Hallock, K. J., Lee, D. K. & Ramamoorthy, A. MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer ...
Hi netters, Could someone direct me to some references that relates the structure of Magainin 1 (produced in skin glangs) of X. ... Magainin 1 (MGN 1) of X.laevis. Rafael N Szeinfeld szeinfel at FOX.CCE.USP.BR Fri Nov 26 17:50:51 EST 1993 *Previous message: ...
Retapamulin: a new topical antibiotic for the treatment of uncomplicated skin infections. Drugs Today (Barc) 44:91-102. doi: ... In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother 43:782-788. ... Ethics statement.All primary human skin and bronchial epithelial cells used in this study were isolated from surplus tissue ... These models represent the epidermal part of the human skin and contain a fully differentiated epidermis and stratum corneum ( ...
Work on "magainins," as he called them, from the Hebrew word for "shield," quickly commandeered his attention and the full ... In 1986 Zasloff serendipitously discovered a new family of potent antibiotics in the skin of the African clawed frog. ... Zasloffs efforts to develop magainins as therapeutically useful drugs were frustrated within the bureaucracy of the NIH, and ...
Zasloff, M. Magainins, A class of antimicrobial peptides from Xenopus skin: Isolation, Characterization of two active forms, ... Since the isolation of magainins from frog skin in 1987 [31], there have been many attempts to develop antibiotics from the ... Pexiganan (also known as MSI-78), a synthetic variant of magainin 2, is one of the best-investigated AMPs in terms of drug ... Maloy, W.L.; Kari, U.P. Structure-activity studies on magainins and other host defense peptides. Biopolymers 1995, 37, 105-122 ...
... researchers discovered that frogs oozed a new class of natural antibiotics in their skins, which were later named "magainins." ...
... which is isolated from the skin of frogs, is a representative antimicrobial peptide (AMP), exerts its antimicrobial activity ... Magainin 2 (Mag 2), which is isolated from the skin of frogs, is a representative antimicrobial peptide (AMP), exerts its ... Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence ChemMedChem. 2019 Nov 20;14(22):1911- ...
Magainins are naturally occurring peptides isolated from the skin of Xenopus laevis that present antibiotic activity toward ... The conjugation of magainin II (MG2) with the N-terminus of the cell penetrating peptide penetratin (Antp) resulted in a fusion ... Breast and prostate cancers are the most frequently diagnosed cancer in women and men aside from skin cancer (Jemal et al., ... showed that nine synthetic magainin peptide analogs lyse in a rapid and irreversible way several hematopoietic tumors with a ...
Zasloff, M. (1987). Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active ... Magainin of 23-mer and Caerin 1.1 of 25-mer, two frog skin-derived AMPs) usually form toroidal pores with curved peptide-lipid ... Magainin 2 (pdb 4MGP), an analog of frog skin AMP. Residues with different side-chain natures are indicated in different colors ... Murzyn, K., and Pasenkiewicz-Gierula, M. (2003). Construction of a toroidal model for the magainin pore. J. Mol. Model. 9, 217- ...
Skin penetration of paclitaxel from the MEs was assessed for 1-12 hours using porcine skin and Franz diffusion cells. Among the ... Keywords: microemulsion, nanocarriers, protein transduction domains, paclitaxel, skin, transdermal ... of various classes to improve cutaneous paclitaxel delivery and efficacy in skin tumor models was evaluated. Microemulsions ( ... addition on the ME irritation potential was assessed by measuring interleukin-1α expression and viability of bioengineered skin ...
Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterisation of two active forms and ... The skin of the frog is a thin, flexible integument that aids in respiration and water absorption.16 The skin is highly ... They found that the use of amphibian skins from the genus Rana as temporary grafts for patients with severe skin loss was a ... Frogs have a smooth, moist skin with few warts and live near or in water, whereas toads have a rough, drier skin with warts, ...
Meyer W, Poehling HM, Neurand K: Intraepidermal distribution of free amino acids in porcine skin. J Dermatol Sci. 1991 Sep;2(5 ... Cuervo JH, Rodriguez B, Houghten RA: The Magainins: sequence factors relevant to increased antimicrobial activity and decreased ...
AMPs such as magainin 2 from frog skin are best known as membrane-active agents forming channels or pores (8, 28, 45). In ... Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes. Eur. J. Pharmacol.226:287-296. ... Magainin 2 in action: distinct modes of membrane permeabilization in living bacterial and mammalian cells. Biophys. J.95:5757- ... Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore. Biochemistry34: ...
Magainin 2 is pore-forming antimicrobial peptide on lipid matrix of bacterial membrane, secreted from the skin of the African ... Magainin 2 induces bacterial cell death showing apoptotic properties.. by AAPPTec , Nov 12, 2014 ... Magainin 2 induces bacterial cell death showing apoptotic properties. Lee W, Lee DG., Curr. Microbiol., 2014, 69, 794-801. ...
Zasloff M (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active ...
... whereas magainin alone penetrated poorly into the skin. Together, these data suggest that NLS-ethanol increased magainin ... Finally, skin permeability was enhanced by changing the charge of magainin peptide via pH change. We modulated pH from 5 to 11 ... In contrast, skin permeability was unaffected by exposure to magainin without co-enhancement by NLS-ethanol. To elucidate the ... Therefore, we tested the hypothesis that magainin, a pore-forming peptide, can increase skin permeability by disrupting stratum ...
... magainins, cecropins, and tachyplasins, has provided a new way to fight antibiotic-resistant microorganisms. The wide spectrum ... fold blood flow as normal skin, Fig. 7(B-c), whereas PACT with ZnPc. -. S. 4. showed ∼. 2.8. -fold blood flow as normal skin in ... C) Analysis of the blood flow ratio under wound-skin of rats 2 weeks after PACT with ZnPc. -. (. Lys. ). 5. or ZnPc. -. S. 4. . ... B) Three representative speckle images of the wound-skin rats treated with ZnPc-S4 (a) or ZnPc. -. (. Lys. ). 5. with (c) or ...
... the magainins isolated from skin secretions of the African clawed frog Xenopus laevis (Bevins and Zasloff, 1990), the ... Peptides from frog skin. Annual Review of Biochemistry, 1990, vol. 59, pp. 395-414. Boman et al. Cell-free immunity in insects ... Mor A, Nicolas P (1994) Isolation and structure of novel defensive peptides from frog skin. Eur J Biochem 219: 145-154. ... A family of bombinin-related peptides from the skin of Bombina variegata. European Journal of Biochemistry, 1991, vol. 199, pp ...
A. Zairi, F. Tangy, K. Bouassida, and K. Hani, "Dermaseptins and magainins: antimicrobial peptides from frogs skin-new sources ... Dermaseptins and magainins are two classes of cationic, amphipathic α-helical peptides identified in the skin extracts of frogs ... AMPs such as magainins [111], defensins [112], BMAP-27 and BMAP-28 [113], gaegurins [114], tachyplesin I [115], cecropins, and ... Cecropin-Magainin (CA-MA). 20. Jurkat T leukemia cells, K562 chronic myeloid leukemia cells [55]. ...
... magainin explanation free. What is magainin? Meaning of magainin medical term. What does magainin mean? ... Looking for online definition of magainin in the Medical Dictionary? ... Related to magainin: protegrin. magainin. A peptide, originally found in the skin of the African clawed frog, which has ... 2008) and magainins, a class of peptides from the skin of African clawed frog, Xenopus laevis (Edelstein et al.. Spermicidal ...
... single cell or multicellular organisms which cause a wide range of human diseases ranging from superficial skin to invasive ... Zasloff M (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active ... Magainin 2 acts as an antifungal against C. neoformans (MIC = 6.25 μg/mL), C. glabrata (MIC = 25.0 μg/ml), C. tropicalis (MIC, ... of C. glabrata and C. krusei [96, 97]. It showed serious drug-drug interactions and side effects like skin rash and ...
Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and ... There may be mentioned such preparations as: pexiganan (magainin analogue), MX-226 (based on indolicidin), NEUPREX (isolated ...
  • The magainins are a class of antimicrobial peptides found in the African clawed frog (Xenopus laevis). (wikipedia.org)
  • examples are the magainins, isolated from the African clawed frog, Xenopus laevis , and the bombinins, isolated from bombinid toads. (hindawi.com)
  • Any of a family of peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis (African clawed frog), which have a broad spectrum of antimicrobial activity against bacteria, fungi, protozoa and viruses. (thefreedictionary.com)
  • 1987) Magainins , a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. (thefreedictionary.com)
  • 2008) and magainins , a class of peptides from the skin of African clawed frog, Xenopus laevis (Edelstein et al. (thefreedictionary.com)
  • Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. (aaem.pl)
  • King, Jay D. / Host-defense and trefoil factor family peptides in skin secretions of the Mawa clawed frog Xenopus boumbaensis (Pipidae) . (elsevier.com)
  • A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. (bvsalud.org)
  • Seven peptides (XT-1-XT-7) with antimicrobial activity were isolated from norepinephrine-stimulated skin secretions of the diploid clawed frog, Xenopus tropicalis. (elsevier.com)
  • Se estudiaron la anatomía microvascular e histomorfología de los órganos olfatorios y vomeronasales de Xenopus laevis Daudin adultos, mediante microscopía electrónica de barrido de moldes de corrosión vascular y secciones de tejido seriadas, teñidas e incluídas en paraplast. (bvsalud.org)
  • Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. (ulster.ac.uk)
  • Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line. (ulster.ac.uk)
  • Following well-advertised magainins from the skin of Xenopus laevis, a number of cationic peptides from various amphibians have been isolated and found to have a broad-spectrum of antimicrobial activity [2]. (scribd.com)
  • The company attempted to develop squalamine, trodusquemine, and pexiganan (a version of a magainin), but the company closed in 2009 without having brought any products to market. (wikipedia.org)
  • A magainin derivative, pexiganan, is in phase-3 trials for diabetic ulcers. (thefreedictionary.com)
  • There may be mentioned such preparations as: pexiganan (magainin analogue), MX-226 (based on indolicidin), NEUPREX (isolated from human BPI (bactericidal/permeability-increasing) protein), IB-367 (variant of porcine protegrin), P113 (based on histatin), daptomycin, polymyxins, as well as peptidomimetics. (aaem.pl)
  • The 1st which has reached the stage III trials can be Pexiganan, a magainin II homologue. (mglur.info)
  • More recent investigations indicate that this in-planar alignment is also found when PGLa and magainin in combination exert synergistic pore-forming activities, where studies on the mechanism of synergistic interaction are ongoing. (springer.com)
  • PGLa and magainin 2 (MAG2) are amphiphilic -helical membranolytic peptides from frog epidermis with known synergistic antimicrobial activity. (healthcarecoremeasures.com)
  • These peptides were purified to near homogeneity and structural characterization showed that they belong to the magainin (2 peptides), peptide glycine-leucine-amide (PGLa) (1 peptide), xenopsin precursor fragment (1 peptide), and caerulein precursor fragment (CPF) (6 peptides) families. (ulster.ac.uk)
  • Zasloff helped found a company, Magainin Pharmaceuticals (subsequently called Genaera) to develop magainins into drugs. (wikipedia.org)
  • Magainin Pharmaceuticals, Inc. was founded in the late 1980s to commercialize the peptides. (wikipedia.org)
  • En esa investigacion, el equipo dirigido por el doctor Nicholas Nicolaides, del Instituto de medicina molecular de la firma Magainin Pharmaceuticals en Plymouth Meeting (Pennsylvania), logro aislar en un raton un gen responsable de la hipersensibilidad de los bronquios, considerada como una de las causas del asma. (thefreedictionary.com)
  • Using a synthetic version of the substance found in frogs, Magainin Pharmaceuticals of Plymouth Meeting, Pa. (thefreedictionary.com)
  • He and his colleagues at Magainin Pharmaceuticals, a company he founded in Plymouth Meeting, Pa. (thefreedictionary.com)
  • Jacob co-founded Magainin Pharmaceuticals and served as its COO until 1996. (thefreedictionary.com)
  • Nicolaides was the Director of Research at Magainin Pharmaceuticals, where his research focused on the development of bio-therapeutics to treat respiratory disease. (thefreedictionary.com)
  • Horvitz's first biotech company was Magainin Pharmaceuticals Inc. (thefreedictionary.com)
  • Dougherty held senior positions with Magainin Pharmaceuticals, Inc. (thefreedictionary.com)
  • From 1998 to 2000, Mr. Molnar served as Director of Finance and Business Development at Magainin Pharmaceuticals. (bio-medicine.org)
  • Mr. Luci says that in over 500 patients treated by Locilex's prior owner, Magainin Pharmaceuticals, the product demonstrated an excellent safety and tolerability profile, no systemic absorption and no bacterial resistance or cross-resistance to other antibiotics. (biotuesdays.com)
  • In the study by Matanic and Castilla (2004), the in vitro antiviral activity of antimicrobial cationic peptides cecropin A, melittin, magainin I and II, and indolicidin against the arenavirus Junin virus (JV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. (thefreedictionary.com)
  • The present report clearly demonstrates that the skin secretions of bombinid toads continue to represent a source of peptides of novel structure that could provide templates for the design of therapeutics. (hindawi.com)
  • Thus, in order to survive in such conditions, they have developed a potent chemical defense system within their skin secretions that contains, on the one hand, numerous pharmacologically active peptides to ward off predators and, on the other hand, a plethora of broad-spectrum antimicrobial peptides (AMPs) to prevent microbial infection [ 2 ]. (hindawi.com)
  • An extensive literature search was conducted using the following keywords: frog or anuran secretions, frog skin properties, frog antimicrobial activity, frog antifungal activity, antimicrobial peptides, African frog secretions, antibiotic resistance, frog species pharmacological importance and frog secretion techniques. (scielo.org.za)
  • 7 Popular remedies often were obtained from animal body parts or animal products, such as skin, horn, corporal secretions and excrement, or from animal housing (e.g. nests and cocoons). (scielo.org.za)
  • A novel peptide with antibacterial effects and without hemolytic activity was purified from skin secretions of Rana ridibunda by multisteps cation-exchange FPLC, reversedphase HPLC and was called Ridibundin 1. (scribd.com)
  • Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. (semanticscholar.org)
  • AMPs such as magainin 2 from frog skin are best known as membrane-active agents forming channels or pores ( 8 , 28 , 45 ). (asm.org)
  • Peptides from frog skin. (freepatentsonline.com)
  • The vast majority of AMPs are isolated from the frog skin. (eurekaselect.com)
  • Notably, recent evidence suggests that synthesis of AMPs in frog skin may confer an advantage on a particular species, although they are not essential for survival. (eurekaselect.com)
  • Frog skin AMPs exert potent activity against antibiotic-resistant bacteria, protozoa, yeasts, and fungi by permeating and destroying the plasma membrane and inactivating intracellular targets. (eurekaselect.com)
  • This review focuses on these frog skin AMPs and the mechanisms underlying their antimicrobial activity. (eurekaselect.com)
  • Bevins C. L, Zasloff M. Peptides from frog skin II Annu. (bio-cat.ru)
  • Based on their primary structures and/or secondary structural characteristics, AMPs isolated from amphibian skin can be classified into three broad groups [ 4 - 6 ]. (hindawi.com)
  • AMPs were first reported from amphibian skin by Csordás and Michl in 1970, when they described the peptide bombinin, a 24-residue antimicrobial and haemolytic peptide from the skin of the European yellow-bellied toad, Bombina variegata [ 12 ]. (hindawi.com)
  • One much investigated alternative are antimicrobial peptides (AMPs): a wide range of natural sequences with very promising activities is available (for example, magainin 2, one of the many AMPs from the skin of frogs, see image), but a range of problems are preventing their widespread use so far: toxicity, instability and high production costs. (wur.nl)
  • Anuran (frogs and toads) skin contains abundant AMPs that can be developed therapeutically. (eurekaselect.com)
  • Bechinger B, Aisenbrey C, Bertani P (2005) Detergent-like properties of magainin antibiotic peptides: a 31 P solid-state NMR spectroscopy study. (springer.com)
  • In support of these hypotheses, synergistic enhancement of transdermal permeation can be observed with magainin peptide in combination of N-lauroyl sarcosine (NLS) in 50% ethanol-PBS solution. (gatech.edu)
  • Magainin II shows a synergistic effect with cecropin A (J Antimicrob Chemother. (unmc.edu)
  • Derivative 2: MSI-594 (provided by Ed Ezell) (sequence GIGKFLKKAKKGIGAVLKVLTTGL-NH2) is engineered based on magainin and melittin. (unmc.edu)
  • Magainin 2 (Mag 2), which is isolated from the skin of frogs, is a representative antimicrobial peptide (AMP), exerts its antimicrobial activity via microbial membrane disruption. (nih.gov)
  • A peptide, originally found in the skin of the African clawed frog, which has antimicrobial activity. (thefreedictionary.com)
  • Chen H. C. Antimicrobial activity of synthetic magainin peptides and several analogues ff Proc. (bio-cat.ru)
  • We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine β -carbonylphthalocyanine zinc ( ZnPc-(Lys) 5 ). (spiedigitallibrary.org)
  • Derivative 3: NSI-99: transgenic plants: expression of a magainin analog (MSI-99, sequence GIGKFLKSAKKFGKAFVKIKNS-NH2, 22mer, more basic) in tomato and banana reduced bacterial speck disease (Planta. (unmc.edu)
  • Mammalian host defense peptides book Mammalian Host Defense Peptides EDITED BY Deirdre A. Devine University of Leeds Robert E. Hancock University of British Columbia v. The dermaseptins are a superfamily of gene-encoded host defense peptides that are produced by the skin of frogs belonging to the family Hylidae. (siyamiozkan.com)
  • 4 - 6 Thus, nanocarriers capable of improving paclitaxel cutaneous localization while limiting its transdermal permeation could potentially allow the use of this drug for the treatment of skin tumors. (dovepress.com)
  • This suggests that an attractive interaction between the drug and magainin peptide improves transdermal flux. (gatech.edu)
  • Molecular cloning of bombinin-encoding cDNAs from skin found that bombinins and bombinin Hs were coencoded on the same precursor proteins. (hindawi.com)
  • Transgenic potato lines expressing a synthetic magainin gene show improved resistance to the bacterial plant pathogen, Erwinia carotovora. (agriculture-xprt.com)
  • In addition to the star peptide Magainin 1, we synthesised a gene for a linear Magainin 1 peptide as well. (igem.org)
  • The expression vectors had identical gene regulatory elements to that used for the Magainin 1 Star peptide. (igem.org)
  • Of the 160 antibiotics in use in the U.S. today, only one -- vancomycin -- stands shakily against uncontrolled ravages of Staphylococcus aureus, or golden staph, the most common cause of skin, wound, and blood infections. (cnn.com)
  • 3 For example, S. aureus can cause a range of illnesses, from minor skin infections to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome, bacteremia, and sepsis. (spiedigitallibrary.org)
  • Fungi are eukaryotic, single cell or multicellular organisms which cause a wide range of human diseases ranging from superficial skin to invasive life-threatening infections. (springer.com)
  • Impetigo is a highly contagious bacterial skin infection and is one of the most common skin infections in children. (readbyqxmd.com)
  • Common Skin Conditions in Children: Skin Infections. (readbyqxmd.com)
  • Skin infections account for a significant subset of dermatologic conditions of childhood. (readbyqxmd.com)
  • Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus. (readbyqxmd.com)
  • Omadacycline is a first-in-class aminomethylcycline antibiotic with oral and IV formulations with a broad spectrum of activity designed for community-acquired bacterial infections such as acute bacterial skin and skin structure infections (ABSSSI), community-acquired bacterial pneumonia (CABP) and urinary tract infections (UTIs), including serious infections that are increasingly leading to hospitalization and where resistant bacteria are a growing clinical concern. (bio-medicine.org)
  • Wound infection is a common problem in hospitals and is typically caused by the antibiotic-resistant Staphylococcus aureus , which is a major pathogen for skin and soft tissue infections worldwide. (jjmicrobiol.com)
  • Skin infections due to S. aureus frequently begin as minor boils or abscesses, which may later progress to severe infections involving muscle or bone, and may even disseminate to the lungs or heart valves (i.e., endocarditis) ( 1 ). (jjmicrobiol.com)
  • The exposure to NLS in 50% ethanol solution increased in vitro skin permeability to fluorescein 15 fold and the addition of magainin synergistically increased skin permeability 47 fold. (gatech.edu)
  • Skin ageing processes act synergistically to alter the structure, organization, and composition of elastin and collagen. (allindianpatents.com)
  • Among the PTD-containing formulations, paclitaxel skin (stratum corneum + epidermis and dermis) penetration at 12 hours was maximized with ME-T, whereas ME-TAT provided the lowest penetration (1.6-fold less). (dovepress.com)
  • It is well known that drug delivery into/across the skin is restricted by the cutaneous barrier provided mainly (but not exclusively) by the stratum corneum (SC). (dovepress.com)
  • The primary reason for such limited development is the difficulty in permeating the stratum corneum layer of human skin. (gatech.edu)
  • Magainin peptide was previously shown to disrupt vesicles from stratum corneum lipid components and this ability of magainin allows us to propose that magainin can increase skin permeability. (gatech.edu)
  • Therefore, we tested the hypothesis that magainin, a pore-forming peptide, can increase skin permeability by disrupting stratum corneum lipid structure and that magainin¡¯s enhancement requires co-administration of a surfactant chemical enhancer to increase magainin penetration into the skin. (gatech.edu)
  • These analyses showed that NLS-ethanol disrupted stratum corneum lipid structure and that the combination of magainin and NLS-ethanol disrupted stratum corneum lipids even further. (gatech.edu)
  • Furthermore, confocal microscopy showed that magainin in the presence of NLS-ethanol penetrated deeply and extensively into stratum corneum, whereas magainin alone penetrated poorly into the skin. (gatech.edu)
  • Together, these data suggest that NLS-ethanol increased magainin penetration into stratum corneum, which further increased stratum corneum lipid disruption and skin permeability. (gatech.edu)
  • Interviewed in 1987, Zasloff explained: "I used it because it came from the skin and it was shielding, in my opinion. (wikipedia.org)
  • peptide and the linear Magainin 1 peptide, the genes were synthesised by GenScript and delivered in pSB1C3. (igem.org)
  • In interactions with model membranes, magainin 2 initially binds to the interface of the lipid bilayer parallel to the surface. (asm.org)
  • Therefore, in order to explore the antimicrobial potential of this species, we have investigated the biological activities and membrane interactions of three peptides isolated from the anuran skin secretion. (biomedcentral.com)
  • More than a decade ago, for example, researchers discovered that frogs oozed a new class of natural antibiotics in their skins, which were later named "magainins. (nationalgeographic.com)
  • We present evidence that magainin I, a 23 residue antibiotic peptide, undergoes a concentration dependent phase transition in synthetic lipid multilayers. (rice.edu)
  • likely due to magainin, an antibiotic, antifungal, antiparasi-tic and antiviral, which has been found on its skin.21However, even if subclinical, an infection is likely to affect the physiology, immunology, development, reproduction and overall response to stress from a purely medical pointof view. (medicpdf.com)
  • Magainin 2 is pore-forming antimicrobial peptide on lipid matrix of bacterial membrane, secreted from the skin of the African clawed frog. (peptide.com)
  • Early on, using oriented solid-state NMR spectroscopy, it was found that the amphipathic helices formed by magainins are active when being oriented parallel to the membrane surface. (springer.com)
  • Zasloff left Penn in 1992 and joined Magainin full time. (wikipedia.org)
  • The key to both magainin and the arylamide polymers is that they are amphiphilic - one side attracts water while the other repels it. (innovations-report.com)
  • Even 30 years after the discovery of magainins, biophysical and structural investigations on how these peptides interact with membranes can still bear surprises and add new interesting detail to how these peptides exert their antimicrobial action. (springer.com)
  • Amphibians are generally slow moving, soft skinned and inhabit environments that are often laden with potentially pathogenic microbes [ 1 ]. (hindawi.com)
  • We modulated pH from 5 to 11 to change the magainin charge from positive to neutral, which decreased skin permeability to a negatively charged fluorescein and increased skin permeability to a positively charged granisetron. (gatech.edu)
  • Unlike the Magainin 1 star, the arms of this peptide serve not as active peptides themselves, but as inert structural linkers. (igem.org)
  • Cruz-Chamorro L, Puertollano MA, Puertollano E, de Cienfuegos GA, de Pablo MA (2005) In vitro biological activities of magainin alone or in combination with nisin. (springer.com)
  • Antimicrobial peptide magainin II, isolated from the skin of the African clawed toad, has shown activity in vitro against a range of micro-organisms. (agriculture-xprt.com)
  • With dermaseptin B2, a 33 residue long and mostly α-helical peptide isolated from the skin of the South American frog Phyllomedusa bicolor , we found that the ion specificity of its pores induced in bilayers is modulated by phospholipid-charged headgroups. (springer.com)
  • In NMR, essentially all peptides are developing a pore, however in leakage just a very little proportion of skin pores are formed, that is nevertheless more than enough to provide vesicle leakage in a minute. (healthcarecoremeasures.com)
  • A peptide called magainin, first found in the skin of the African clawed frog, holds the secret to creating bacteria-killing surfaces, according to researchers at the University of Pennsylvania. (innovations-report.com)
  • Like magainin, the modified arylamide polymer can disrupt the cell membranes of bacteria without harming the membranes of other types of cells, such as our own. (innovations-report.com)
  • Here, we report the molecular cloning of two novel cDNAs from a skin secretion-derived cDNA library of B. variegata whose open-reading frames each encode a novel bombinin (GIGGALLNVGKVALKGLAKGLAEHFANamide) and a C-terminally located single copy of a novel nonapeptide (FLGLLGGLLamide or FLGLIGSLLamide). (hindawi.com)
  • Our original approach was to replace the peptide backbone found in magainin with one of arylamide, which is relatively easy to create in the lab," Doerksen said. (innovations-report.com)
  • A positive band test is found infrequently in clinically normal skin of patients with other connective tissue disorders. (storysteel.gq)
  • Kinetics of pore formation by an antimicrobial peptide, magainin 2, in phospholipid bilayers. (thefreedictionary.com)
  • The first amphibian skin antimicrobial peptide (AMP) to be identified was named bombinin, reflecting its origin from the skin of the European yellow-bellied toad ( Bombina variegata ). (hindawi.com)
  • In fact, the largest cohort of AMP structures currently known is from amphibian skin sources, despite their presence in many other life forms, including plants [ 3 , 4 ]. (hindawi.com)
  • This study provides new insight on the mechanisms of PACT in bacterial skin infection. (spiedigitallibrary.org)
  • Impetigo is the most common bacterial skin infection in children two to five years of age. (readbyqxmd.com)
  • The Penn scientists have taken a joint experimental-computational approach to mimicking magainin. (innovations-report.com)
  • In this study, the ability of nanocarriers containing protein transduction domains (PTDs) of various classes to improve cutaneous paclitaxel delivery and efficacy in skin tumor models was evaluated. (dovepress.com)
  • 3 Only formulations for systemic use are currently available, but despite their efficacy against tumors affecting the skin, severe systemic adverse effects limit their use in dermatology. (dovepress.com)
  • 3 , 5 , 7 , 8 In this context, this study was aimed at evaluating the cutaneous delivery, safety, and efficacy of paclitaxel nanocarriers in bioengineered models of healthy and tumor-containing skin. (dovepress.com)
  • While an FDA advisory committee unanimously approved the safety of Locilex, the committee cited inconsistencies with the efficacy results and recommended that Magainin conduct an additional Phase 3 placebo-controlled study. (biotuesdays.com)
  • Skin penetration of paclitaxel from the MEs was assessed for 1-12 hours using porcine skin and Franz diffusion cells. (dovepress.com)
  • 2 However, the majority of the drugs available do not meet these requirements, and penetration-enhancing strategies are needed to improve their skin penetration. (dovepress.com)
  • Although ageing is thought to be a genetically programmed phenomenom, environmental factors, such as ultraviolet (UV) radiation from sunlight, chemicals, cigarette smoking, high sugar diets, diseases (which also may have a genetic cause), medical treatments and air pollution, may also cause premature skin ageing. (allindianpatents.com)
  • As skin ages, fibroblasts lose their ability to react to growth factors for the proliferation and synthesis of collagen, and the dermis and the epidermis become thin (West, Arch. (allindianpatents.com)
  • The highly sensitive protein separation technique two-dimensional polyacrylamide gel electrophoresis was used to study the cellular protein synthesis in 1) cultured human rheumatoid and 2) normal synovial fibroblasts and 3) normal skin fibroblasts. (storysteel.gq)