Skin Irritancy Tests
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Local Lymph Node Assay
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Sister Mary Joseph's Nodule
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)
Sequence Analysis, DNA
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Sensitivity and Specificity
Encyclopedias as Topic
Batch Cell Culture Techniques
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.
A tissue preparation technique that involves the injecting of plastic (acrylates) into blood vessels or other hollow viscera and treating the tissue with a caustic substance. This results in a negative copy or a solid replica of the enclosed space of the tissue that is ready for viewing under a scanning electron microscope.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing. (1/45)PURPOSE: To investigate the suitability of chitosan films prepared using two different solvents, acetic acid (Chitosan-AA) and lactic acid (Chitosan-LA), for wound dressing, in comparison with a commercial preparation, Omiderm. METHODS: The mechanical and in-vitro bioadhesive strength properties of Chitosan-AA, Chitosan-LA, and Omiderm were investigated using texture analyzer equipment. The vapour permeability of chitosan films was determined using a method for evaluation of moisture permeability of containers and packaging material described in USP XXII. In addition, the biological evaluations were performed via primary skin irritation, intracutaneous, and systemic injection tests. RESULTS: The three preparations differed significantly in terms of the mechanical and bioadhesive strength properties. Chitosan-LA exhibited a lower tensile strength, but more flexible and bioadhesive than Chitosan-AA. Chitosan film was found to be permeable to water vapour. Chitosan-LA and Omiderm were non-irritant and did not cause any skin allergic reaction. In contrast, Chitosan-AA films inflicted adverse skin reactions. Nevertheless, no gross sign of toxicity was encountered from the systemic injection of the extracts of the three preparations. CONCLUSION: Chitosan films demonstrated significantly different mechanical and bioadhesive strength properties from Omiderm. Chitosan-LA was more soft, flexible, pliable and bioadhesive when compared to Chitosan-AA films. Furthermore, Chitosan-LA did not cause erythema, edema and systemic toxicity. Hence, Chitosan-LA film is suitable to be used in the management of wound healing and skin burn. (+info)
Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization. (2/45)Skin sensitization potential of low molecular weight chemicals was assessed by analyzing peptide-conjugate formation. Chemicals were incubated with a peptide, glutathione, and resultant mixtures were analyzed by mass spectrometry. Eighteen chemicals were assessed, and new peaks corresponding to chemical-peptide conjugates were detected for 13 of 14 known sensitizers. Conjugates were not detected for 4 negative chemicals. The method has advantages as a simple screening assay for assessing the sensitization potential of chemicals. (+info)
Preliminary pharmacological study of purified snake enzymatic cream isolated from Agkistrodon Halys venom. (3/45)To investigate the pharmacological and toxicological actions of purified snake enzymatic cream (PSE) isolated from Agkistrodon Halys Venom, erythematous dermatitis was induced by applying dinitrofluorobenezene (DNFB) on the back skin of guinea pigs. Consequent local alterations at different doses of PSE were observed and compared using negative control methods. In skin irritation and acute toxicological experiments, 500 times the effective doses were used in artificially lesioned skin. The marking criteria in the former were based on local manifestations, and in the latter, on changes of some indicators including body weight, breath, and heart rate before and after the experiments. PSE significantly alleviated erythematous dermatitis (p < 0.01, t test) without systemic or local adverse drug reactions within 7 days. PSE as a new drug candidate poses a bright prospect in the prevention and treatment of dermatitis. (+info)
Comparison of poultice-type and tape-type patches containing ketoprofen on human skin irritation. (4/45)Although the patch test for visual skin observation is widely used clinically, it does not allow the mechanisms of side effects to be assessed. In this study, we examined poultice-type KP801 and tape-type KP-T patches containing ketoprofen. The parameters to measure side effects on skin were peeling intensity, amount of stripped stratum corneum, skin moisture and redness of skin color under various mechanical conditions. Since the amount of stripped stratum corneum with the tape-type KP-T patch was higher than with the poultice-type KP801 patch, the bio-adhesive strength of the latter was concluded to be lower. A clear relationship exists between the amount of stripped stratum corneum and skin moisture after tape-type patch removal, but this was not found with the poultice-type patch because of its hydration effects. Peeling intensity, one parameter to predict pain at the time of patch removal, was higher with the KP-T. As for mechanical conditions, when the patch is removed, it is important to remove it as slowly as possible and horizontally, and to avoid any rise in skin temperature. Finally, when a patch is applied to a region with little skin moisture, the amount of stripped stratum corneum may increase accordingly. (+info)
Optimisation of the EpiDerm test protocol for the upcoming ECVAM validation study on in vitro skin irritation tests. (5/45)An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin irritants (I) and non-irritants (NI) according to European Union risk phrases ("R38" or no classification). The tests evaluated were EpiDerm, EPISKIN, PREDISKIN, the non-perfused pig ear method, and the mouse skin integrity function test (SIFT). Whereas reproducibility of the two human skin model tests and SIFT was acceptable, none of the methods was deemed ready to enter a formal validation study due to their low predictivity. The ECVAM Skin Irritation Task Force therefore suggested improvements of protocols and prediction models for these tests. Furthermore, it was agreed that experience gained with the two human-skin models be shared, and a common protocol should be developed for EpiDerm and EPISKIN (Zuang et al., 2002). When we applied an improved EPISKIN protocol (Portes et al., 2002) to the EpiDerm model, an acceptable specificity (80%) was achieved, whereas the sensitivity (60%) was far too low. In 2003, the EPISKIN protocol was further refined by extension of the post-incubation period following chemical exposure. In the current study, we evaluated this EPISKIN refinement by applying it to EpiDerm. In addition, we developed technical improvements for the application of the test chemicals and rinsing procedure, which reduced the variability of results and increased the percentage of correct predictions. A set of twenty non-coded reference substances from the ECVAM prevalidation study phase III (Fentem et al., 2001) was tested with the final protocol in three independent runs. Both high sensitivity (80%) and high specificity (78%) were achieved, and the statistical probability of correct classifications was high, so that the test is now regarded ready for formal validation. (+info)
Essential oils from sweet basil (Ocimum basilicum) as novel enhancers to accelerate transdermal drug delivery. (6/45)The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and tri-) were identified in both the lower-polarity fraction (OB-1) and higher-polarity fraction (OB-2). In vitro skin permeation and deposition of indomethacin were significantly enhanced after treatment with OB essential oils. The enhancing effect of OB-1 was greater than that of OB-2 in the in vitro permeation and in vivo cutaneous microdialysis analyses as well as in the plasma concentration of indomethacin. On the other hand, the in vivo study showed that OB-2 had a greater ability to retain the drug within the skin than did OB-1. Enhancement of the skin permeation of drugs by OB essential oils might be mainly due to improvement in the partitioning of the drugs to the stratum corneum. Both in vitro cell cultures (keratinocytes and skin fibroblasts) and in vivo transepidermal water loss showed no or only negligible irritation to skin by OB essential oils. (+info)
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. (7/45)Interleukin (IL)-10 is a regulator of inflammatory responses and is secreted by a variety of different cell types including T cells. T regulatory cells have been shown to suppress immune responses by IL-10-dependent, but also IL-10-independent, mechanisms. Herein, we address the role of T cell-derived IL-10 in mice with an inactivation of the IL-10 gene restricted to T cells generated by Cre/loxP-mediated targeting of the IL-10 gene. Splenocytes from this T cell-specific mutant secrete increased amounts of proinflammatory cytokines after activation in vitro compared with show enhanced contact hypersensitivity reactions, and succumb to severe immunopathology upon infection with Toxoplasma gondii. Despite intact IL-10 genes in other cell types, the dysregulation of T cell responses observed in the T cell-specific IL-10 mutant closely resembles the phenotype in complete IL-10 deficiency. However, in contrast to complete IL-10 deficiency, sensitivity to endotoxic shock and irritant responses of the skin are not enhanced in the T cell-specific IL-10 mutant. Our data highlight the importance of T cell-derived IL-10 in the regulation of T cell responses and demonstrate that endotoxic shock and the irritant response of the skin are controlled by IL-10 from other cell types. (+info)
Toxicity of some phenolic derivatives--in vitro studies. (8/45)Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) was tested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson's correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC(50) values) and physicochemical parameters of compounds or their toxicity in vivo expressed by LD(50) values. The studies showed that physicochemical properties of compounds seemed to have less influence on their cytotoxic potency than structural properties. Cytotoxicity of the compounds probably depends on the number of -OH groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC(50) values and LD(50) values determined following rabbit skin administration and experimental skin irritation score. (+info)
EPISKIN at MEDTEC Europe 2017
After being awarded the best overall abstract for the validation study of the in vitro skin irritation tests of medical devices at the last Society of Toxicology Congress in Baltimore - USA, EPISKIN is exhibiting at MEDTEC Europe 2017 in Stuttgart in Germany.. MEDTEC Europe is one of the largest event dedicated to Medical Devices.. Join us at booth 3E51.. Round Robin Study to Evaluate the Reconstructed Human Epidermis (RhE) Model as an In Vitro Skin Irritation Test tor Detection of Irritant Activity In Medical Device. ...
α,α,6,6-tetramethylbicyclo[3.1.1]hept-2-ene-2-p... - Registration Dossier - ECHA
Skin corrosion: In view of the absence of skin and eye irritation the substance is not corrosive Skin irritation In accordance to OECD guideline 439 and GLP the test substance was examined for its in vitro skin irritation potential using EpiDerm™ reconstructed skin membranes. In the in vitro skin irritation test, the skin membranes were topically exposed to the undiluted test substance for 60 min. The test was performed in triplicate. Viability of the epidermal cells was assessed using the MTT test after 42 h of culture. Negative and positive controls were run in parallel. All acceptance criteria were met and therefore the study was considered valid. After exposure to the test substance the mean tissue viability was 105 ± 11 % compared to the concurrent negative control group. Based on the results obtained in the present study the test substance is not considered to be a skin irritant. Eye irritation In accordance to OECD guideline 438 and GLP the test substance was examined for its in vitro ...
Skin irritation test on 3D reconstructed epidermis - abich.ca - Biological and chemical analysis
Skin irritation test on 3D reconstructed epidermis for cosmetics: Chemical substances or mixtures. Claim: Non-irritant for the skin.
4-(2-butenylidene)-3,5,5-trimethylcyclohex-2-en... - Registration Dossier - ECHA
Skin The skin irritation potential of the test substance was determined by an in vitro skin irritation test using a reconstructed human skin model according to OECD Guideline 439 and in compliance with GLP (2017). After treatment with the test substance for 60 min the tissue viability decreased to 6.4% compared to the negative control (threshold for irritancy ≤ 50%). Therefore, the test substance is considered to possess an irritant potential. In a next step, the skin corrosion potential of the test substance was assessed by an in vitro skin corrosion test using a human skin model according to OECD Guideline 431 and in compliance with GLP (2017). After treatment with the test substance the mean relative absorbance value did not decrease (3 min exposure: 120.1%; 1 h exposure: 111.9%) compared to the negative control. Therefore, the test substance is not considered be corrosive to the skin. In conclusion, based on available studies, the test substance is considered to be irritating to the skin ...
All about the 56th SOT meeting
EPISKIN participated to the 56th Annual Meeting and ToxExpo™ of the Society of Toxicology (SOT) at Baltimore (Maryland, March 12-16, 2017). With more than 6800 attendees this congress is one of the world premier event for scientists involved in toxicology and related fields. The two posters co-authored by EPISKIN Academy and the five others onto our models reflect the dynamism and innovation of EPISKIN in this field. The best overall abstract award for the validation study of the in vitro skin irritation tests of medical devices is a recognition of the collaborative work engaged for several years to implement alternative to animal testing approach in this new field. This year again, our booth was the meeting point with our current and future customers to discuss their needs and present our new products. Among the models presented on the booth, T-SkinTM our full thickness model has attracted a lot of interest from our visitors.. Posters on available on demand:. EpiSkinTM Micronucleus Assay: A ...
1,12-dodecanediyl bismethacrylate - Registration Dossier - ECHA
In vitro skin irritation test (Valin 2013)/ read-across: The objective of this study was to evaluate the skin irritation potential of the test item using the Episkin reconstructed human epidermis model. The study design was based upon international guidelines (OECD Guideline No. 439 and Commission Regulation (EC) No. 761/2009, B.46). The study was conducted in compliance with CiToxLABs standard operating procedures and the principles of Good Laboratory Practice. Preliminary tests were performed to detect the ability of the test item to directly reduce MTT as well as its colouring potential. Following the preliminary tests, the skin irritation potential of the test item was tested in the main test. The test item and both the negative and positive controls were topically applied on triplicate tissues and incubated at room temperature for 15 (± 1) minutes. At the end of the treatment period, each tissue was rinsed with D-PBS and incubated for 42 (± 1) hours at, 5% CO2 in a humidified incubator. ...
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Advinus now offers in vitro testing for skin irritation and corrosion - Episkin® Tests | Eurofins Advinus
Advinus has broadened its scope of services through the introduction of in vitro Skin Irritation (OECD 439) and in vitro skin Corrosion tests (OECD 431). These
Human-Based Skin Irritation Tests Can Replace Animals in Safety Evaluation of Medical Devices
New research using reconstructed human epidermis for irritation testing of medical device extracts validated that these models are acceptable replacements for the rabbit intracutaneous irritation test.
Assessment of the in vitro skin irritaion by chemicals using the Vitrolife-Skin TM human skin model AATEX Vo1 13(1)
The European Centre for the Validation of Alternative Methods (ECVAM) is currently supporting formal validation studies of in vitro tests for predicting skin irritancy and corrosivity, including tests employing two human skin models, EPISKINTM and EpiDermTM. When skin models are used to evaluate skin irritancy, it is important that suitable chemical application procedures are used. We evaluated the skin irritancy of 44 chemicals using the postincubation method (10-minutes treatment and 18-hours post-treatment incubation) that we originally developed to predict skin irritancy which is similar to a refined protocol for EPISKINTM proposed in an ECVAM validation study. The sensitivity, specificity, and accuracy obtained with the MTT reduction assay-based prediction model were 77.8%, 76.9%, and 77.3%, respectively while the corresponding values obtained with the interleukin-1α secretion assay-based prediction model were 61.1%, 92.3%, and 79.5%, respectively. Combining these endpoints indicated a ...
Skin Irritation Test of LEO 80185 Gel (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects -...
The purpose of the study is to investigate skin irritation of LEO 80185 [Calcipotriol/betamethasone-dipropionate] gel, gel vehicle and Liquid Paraffin in
Fatty acids, C8-10, mixed esters with adipic... - Registration Dossier - ECHA
a) Category members subject to the REACh Phase-in registration deadline of 31 May 2013 are indicated in bold font. Only for these substances a full set of experimental results and/or read-across is given. Irritation/corrosion Discussion Skin irritation CAS 95912-89-3 A GLP-conform in vitro skin irritation study according to OECD guideline 439 was performed with Fatty acids, C8-10, mixed esters with adipic acid and trimethylolpropane (CAS 95912-89-3) (Andres, 2012). In this study, a reconstructed three-dimensional human epidermis model was used to investigate the effects of the undiluted test substance on the viability of epidermal keratinocytes. After 60-min exposure the test substance, the viability of human keratinocytes was 99.4% compared to the negative control PBS (100%). The positive control 5% SDS significantly reduced the viability of cells compared to the negative control, thus fulfilling the criteria for the acceptability of the assay (relative viability ≤ 20%). Since the mean ...
Skin Irritation Test (SIT, OECD 439)
This Method Provides a Mechanistically-relevant Measurement of Cell Viability in Reconstructed Human Epidermis (RhE) Tissues After 1 Topically-applied Chemical Treatment, Relative to Negative Control-treated Tissues.
IIVS | Assays Skin Irritation Corrosion Screening
The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material. A test material is evaluated based on its penetration through the biobarrier membrane into a Chemical Detection System (CDS). The time required for the test material to break through the biobarrier and into the CDS is... Corrositex , Dermal , Skin Irritation Corrosion Screening , Skin Irritation Test ...
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Epiderm Lotion - Composition and Ingredients - - Nigeria | all4insure.ru
Epiderm Lotion is composed of the following active ingredients (salts): Betamethasone Dipropionate(0.643Mg), Gentamicin Sulphate(1Mg), Tolnaftate(10Mg), Iodochlorohydroxy Quinoline(10Mg), Chlorocresol(1Mg)
Alternatives to animal testing - Wikipedia
Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation. However, some claim they are not true alternatives because simulations use data from prior animal experiments and cell cultures often require animal derived products, such as serum or cells. Others say that they cannot replace animals completely as they are unlikely to ever provide enough information about the complex interactions of living systems. Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another alternative is so-called microdosing, in which the basic behaviour of drugs is assessed using human ...
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With the aim of improved prediction of human skin irritation, cytotoxicity tests were conducted using a reconstituted human dermal model (Skin2TM cultured 3-Dimensional Skin Model, ZK1300: 3-D model). A range of water-insoluble substances, namely fatty acids, fatty alcohols and hydrocarbons, were tested with MTT(3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyl tetrazolium bromide) reduction, LDH (lactate dehydrogenase) release and prostaglandin E2(PGE2) release using as cytotoxicity markers. Results for these parameters were compared with those obtained from a cytotoxicity test (MTT reduction assay) using cultured monolayers of human dermal fibroblasts (NB1RGB), from a rabbit primary skin irritation test and from human patch testing ...
Creams For Skin Irritation | Sephora
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EPISKIN and The EPISKIN Academy The reference for 3D models EPISKIN, world leader in tissue engineering, is partnering with industries to develop relevant and reliable safety and efficacy tests for decision making during research and development phases. Some screening tests are already OECD validated as alternatives to animal use, and others are in the process of validation. For more than 26 years EPISKIN is committed to mass produce 52 weeks per year 3D models that exceed market expectations in term of performance, reliability and simplicity.. ...
Sensitive skin care tips
If you have sensitive skin, it is necessary to take good care of the skin to prevent skin irritation. Follow Sensitive skin care tips to avoid skin irritation.
NCI Awards Labcyte $1 Million for Development of High-Throughput Cancer Biomarker Detection Process | www.bioquicknews.com
In a November 20, 2013 press release, Labcyte Inc., the acoustic dispensing company, announced that it has been awarded $1 million to create an innovative process to detect cancer-related proteins in samples, with initial work in breast cancer detection. The unsurpassed precision and accuracy of Labcyte acoustic liquid handling enables biomarker detection by measuring multiple proteins with a MALDI mass spectrometer. Recent work with the Canary Center at Stanford, also supported by the National Cancer Institute, showed the ability to achieve the sensitivity required for quantifying very small amounts of proteins associated with ovarian cancer. Measuring the amount of multiple proteins, and at lower cost, is an essential step in developing new diagnostic tools for disease treatment and monitoring. This cutting-edge process encompasses stable standards and capture of biomarkers with antibodies and expects to achieve greater throughput than traditional liquid chromatography-mass spectrometric ...
IsNtree Sensitive Balancing Moisture Emulsion 120ml - Beautihara
This is a hypo-allergenic moisture lotion for delicate skin, which spreads mildy without heaviness or stickiness. Skin-friendly natural moisturizing ingrediant enhances long-term moisture retention ability. Soft texture doesnt have silicon ingredient and skin irritation test completed. 4.06 oz / 120 ml How To Afte
Dermal Irritation Testing - Bioscience Labs
Dermal irritation testing is conducted using the ET-50 method (time of exposure needed for a test article to reduce the viability to 50% of control tissues) and the EpiDerm tissue model. This model consists of normal (non-cancerous), human cell-derived epidermal keratinocytes cultured to form a multilayered model of the human epidermidis. The dermal irritation evaluation used at BioScience Laboratories involves applying neat test articles to the EpiDerm tissue model. This test method closely approximates the responses to product exposure exhibited by its in-vivo counterpart, the Human Repeat-Insult Patch Testing. Based on the ET-50 and comparison to benchmark materials, the degree of dermal irritancy can be estimated. An additional benefit of dermal irritation testing is that, in many instances, results obtained using animal-based testing do not correlate well with the actual response seen in human tissue.. ...
Stiftung Forschung 3R / 3R Info Bulletins / Identification of new human skin irritation markers for tests with human skin...
Dermatotoxicologists have to protect workers and consumers from chemicals and consumer products that have the potential to i) irritate the skin or the eyes (irritation), ii) elicit toxic responses in combination with UV-light (phototoxicity), iii) corrode the skin (irreversible damage) or iv) sensitise the skin (caused by immunological mechanisms).. Traditionally these tests have been carried out in animals. Critics point out that the results have a limited predictive value for humans, and oppose the suffering involved in these in vivo tests (e.g. the Draize test for skin irritation). Recent advances in our understanding of skin biology have resulted in the development of in vitro tests using cell cultures, skin excised from rat, pig or humans, and reconstructed human skin models. International acceptance of animal-free approaches is high for the detection of severe acute irritants, of phototoxic compounds and of corrosives using a sequential testing strategy with a weight-of-the-evidence ...
Cytotoxicity Test, Skin Irritation, Skin Corrosion | MSCR
MSCR provides comprehensive in vitro toxicology and safety pharmacology services to assess safety profiles early in the discovery process. We offer reliable, high-throughput models of multiplexed toxicity testing to provide quick and cost-effective screening solutions that are suitable for early compound liability assessment.
Quest 2 on Amazon EU Has Disappeared, a Safety Notice Regarding Skin Irritation May Be Why | thesupertimes.com
The European Commission Safety Gate website, which communicates product safety notices to the public, confirms these reports through an alert dated May 12th.. The foam of the product contains substances (e.g.: Propylene carbonate, Phenol, fragrance 7-hydroxycitronellal and Benzocaine) which are skin and eye irritants. Consequently the user could suffer from irritation. The product does not comply with the requirements of the General Product Safety Directive.. The page further notes, The product was sold online, in particular via Amazon, and points to an Oculus Support page addressing the issue, in which Oculus says it has changed its manufacturing processes to reduce the likelihood that trace substances that could lead to skin irritation arent introduced during manufacturing. Oculus is also offering a free replacement of the Quest 2 facepad for headsets manufactured within a certain timeframe.. Oculus has dealt with this issue previously. Back in late December the company published a blog ...
Ethyl Lactate | Cosmetics Info
the greater the absorption. Metabolism and distribution studies showed expected pathways and distribution. Consistent with these data, acute oral studies showed oxalate-induced renal calculi, an increase in renal oxalate, and nephrotoxic effects. No systemic effects were seen with dermal application, but irritation at the site of application was produced. While many studies were performed to evaluate AHA-induced skin irritation, it was common for either the AHA concentration or the pH of the formulation to be omitted, limiting the usefulness of the data. Clinical testing using AHA formulations of known concentration and pH was done to address the issue of skin irritation as a function of concentration and pH. Skin irritation increased with AHA concentration at a given pH. Skin irritation increased when the pH of a given AHA concentration was lowered. Repeat insult patch tests using lotions and creams containing up to 10% Glycolic Acid or Lactic Acid were negative. Glycolic Acid at concentrations ...
6 Common Causes of Dog Skin Irritation
Allergies are a common cause of skin irritation. Whether its an external source like certain fibers around the house or internal sources like their food or an ingredient in the food, the canine body will often react with a dog skin rash causing the dog to scratch ...
What can cause skin irritation | what answered
What can cause skin irritation, Most people seem to pay little attention to their skin. That is perfectly normal behaviour since, until you start to suffer from an unwelcome condition.
Experiencing hives, lump in throat, chest pain, warmth and skin irritation. Reason? - Doctors insight on HealthcareMagic
Question - Experiencing hives, lump in throat, chest pain, warmth and skin irritation. Reason?. Ask a Doctor about diagnosis, treatment and medication for Chest pain, Ask an Allergist and Immunologist
Electrical impedance - a new parameter for oral mucosal irritation tests | SpringerLink
The potential for dental materials to irritate human oral mucosal membranes was assessed by an electrical impedance technique. A small electrode at the site of irritation on the inside of the cheek...
Phenol, styrenated - Registration Dossier - ECHA
Hydrolysis: Data available for the test chemical has been reviewed from authoritative database (OECD SIDS report and HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below: The first study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach , 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable. Next study was reviewed from authoritative database (HSDB) it is concluded that the test chemical is stable to hydrolysis that means it is not hydrolysable. On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis he hydrolysis of test chemical did not reach , 10% in any of ...
Diadermine Dr Caspari Novagen Intense Age Repair range | CosmetoScope
Diadermine clearly wants to communicate with Novagen on the very trendy topics of genes and stem cells. A lot of cosmetic brands are currently surfing on these new targets, like LOréal Paris Youth Code, HR Prodigy Powercell, Dior Capture R60/80 XP, Nivea DNAge,…etc.. To be able to talk about stem cells and genes on its Novagen range, Henkel has been quite smart, avoiding potential problems of ethics or sincerity : the link between Novagen products efficiency and genes and stem cells is quite indirect.. - the only place where it is talked about genes is in the name of the range, Novagen.. - on the pack, there is a statement on the role of stem cells in the epiderm : Stem cells - youth source of the skin : it is known that stem cells are the youth source of the epiderm. Indeed, in a young skin, the good activity of stem cells promotes new cells production and allows the skin to regenerates permanently. With time, stem cells activity is reduced and the skin renewal is slowed down. Result ...
Haplogenotypy variant genů pro epidermální růstový faktor a jeho receptor asociované s gastroezofageální refluxní chorobou a...
Gastroesophageal reflux disease (GERD) is a disease with multifactorial etiopathogenesis, in which the genetic predisposition of an individual also plays a role. Epidermal growth factor (EGF) and its receptor (EGFR) are involved in maintaining tissue integrity and restoring epithelium in injury, two of the main mechanisms that protect esophageal tissue from reflux ...
Octoxynol-3 | Cosmetics Info
CIR Safety Review: The CIR Expert Panel noted that the Octoxynols are chemically similar to Nonoxynols, the safety of which were previously reviewed. Long-chain Nonoxynols (9 and above) were considered safe as used, whereas short-chain Nonoxynols (8 and below) were considered safe as used in rinse-off products and safe at concentrations less than 5% in leave-on formulations. Acute exposure to Octoxynol-9 by bronchopulmonary lavage produced pneumonia, pulmonary edema, and intra-alveolar hemorrhage. No significant effects were noted in short-term oral studies of Octoxynol-9, in subchronic oral studies of Octoxynol-40, or in chronic oral studies of Octoxynol-40.. In skin irritation studies, Octoxynols ranged from nonirritating to moderately irritating. Octoxynols were not eye irritants in one study, but in others some eye irritation was observed. The Octoxynols were not mutagenic. Dermal exposure at three dose levels to Octoxynol-9 failed to induce any developmenta effects. No reproductive toxicity ...
Sodium Lauryl Sulphate in Bareilly,Sodium Lauryl Sulphate Manufacturers and Suppliers from india
Business Directory for Sodium Lauryl Sulphate Suppliers in Bareilly - Get contact details of Sodium Lauryl Sulphate Manufacturers, Wholesale Sodium Lauryl Sulphate Exporters, Best Sodium Lauryl Sulphate Traders & Distributors Across the Bareilly.
Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and...
Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing was performed using rabbits. The OECD Test Guideline 437 Bovine Corneal Opacity and Permeability (BCOP) test method allows determining severely irritating substances without animals, and the recently adopted OECD Test Guideline 492 Reconstructed human cornea-like epithelium test method allows identifying chemicals that neither induce eye irritation nor serious eye damage. For substances applicable to these tests, huge progress has been made in replacing animal testing. The in vitro eye irritation potential of 20 nanosized and 3 non-nanosized materials was investigated in a 2-tier EpiOcular™ Eye Irritation Test (EpiOcular™-EIT) and BCOP testing strategy including histopathology of the bovine corneas. Furthermore, applicability of the testing strategy for nanomaterials was
Corrosion and Irritation Tests of a Dental Aluminum Bronze
Corrosion and irritation tests of a dental aluminium bronze. B.I. ARDLIN*1,2, B. LINDHOLM-SETHSON1 and J.E. DAHL2, 1Umeå University, Sweden, 2NIOM - Nordic Institute of Dental Materials, Haslum, Norway. Objectives: The aims of this investigation were to study the corrosion of a copper-aluminium-nickel alloy for fixed prostheses, and to evaluate possible irritant effects of the corrosion products.. Methods: The alloy NPG+2 with the nominal composition Cu:77.3; Al:7.8; Ni:4.3; Fe:3.0; Zn:2.7; Au:2.0; Mn:1.7, was characterized. Static immersion in saline lactic acid solution was selected to quantify metallic elements released in a milieu simulating the condition of plaque build-up in interproximal areas. Corrosion and surface reactions in artificial saliva and saline solutions were studied by electrochemical techniques including registration of polarization curves and impedance spectra. Irritative effect of the corrosion products was assed by the Hens egg test-chorio-allantoic membrane, ...
In vitro Eye Irritation Test | Creative Bioarray
With over 10 years of experience in working on cell & tissue products and services, Creative Bioarray provides in vitro reconstructed human cornea-like Epithelium (RhCE) model and in vitro eye irritation test services to help industries evaluate eye irritation potential for their chemicals and cosmetic products.
Guggul Lipid Concentrate (90 caps) | The Sunshine Store
Description: Guggul Lipid [Circulatory]. Guggul lipid is a plant extract that has been the subject of several scientific studies that suggest that this extract has the ability to help the body maintain cholesterol and triglyceride levels already within the normal range.. It may also help to maintain the bloods already normal viscosity.. ...
The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT) | SpringerLink
Assessment of the phototoxicity hazard and phototoxic potency (i.e. phototoxic risk) of topically or systemically applied compounds and mixtures is a crucial step in the safety assessment of...
6 Face Cream for Sensitive Skin ⋆ Mens Face Cream
If you are still looking for a face cream for sensitive skin then you will definitely benefit from reading this article. You can find out the ingredients you should avoid and get some great tips to find a safe and effective face cream for men. Face cream for sensitive skin will be designed a certain way in order to be effective and safe.. Best face cream for sensitive skin:. Finding a face cream in winter for dry and sensitive skin will be tricky. As many with sensitive skin will know an unsuitable face cream will cause burning rashes and irritation.. ...
Sensitive skin is a common skin condition that has a low tolerance to various stimuli, most commonly to applications of anything topically such as creams and moisturisers to the skins surface. If you have a sensitive skin you will usually be quoted saying I can only use Cetaphil on my skin. Sensitive skin is commonly a reactive skin condition that produces inflammation, redness and has an impaired barrier.. Skin that is sensitive may also be allergy prone and usally appears if you are prone to eczema, asthma and or rosacea. If your skin is sensitive it will most likely be dehydrated, this is because it doesnt have a well functioning protective barrier to retain and hold moisture. The dehydration (lack of water) can then contribute to and assasabate your sensitive skin even more. Often a sensitive skin is asscociated with low immunity, caused from lifestyle choices, stress, and a general low well being. It can also be genetic and you may have a predisposition if your Mother or Father suffer ...
Lastest Post: #dprogram ALLERBARRIER Essence, a new anti-allergen Japanese #sunscreen milk for sensitive skin. - SgBlogs.com
d program Allerbarrier Essence is an anti-allergen Japanese sunscreen milk for sensitive skin. The sunscreen milk has an extra gentle, additive-free formula featuring Shiseidos new AllerBarrier technology that forms a barrier veil to stop airborne allergens such as pollen and dust from settling on sensitive skin. It gives sensitive skin protection from UV damages, dryness, and irritation thats comfortable and lightweight. Safe and gentle for sensitive skin on adults and babies. For face and body. Resistant to water, sweat, and sebum. Double as a makeup base. Removable with a face wash. The information provided does not represent my view in any way. Full article: http://www.ratzillacosme.com/sun/shiseido-d-program-aller... ...
Do you have sensitive skin? Do you know how to take care of sensitive skin? Here are some FAQs through which you can learn how to take care of sensitive skin. You will also find expert answers for the frequently asked question on skin problems related to sensitive skin.
SENSITIVE SKIN: WHAT IS IT AND HOW DO YOU TAKE CARE OF IT? | Mario Badescu Skin Care Blog
This post is going to bring us back to the question: What is your skin type? (See post: How To Identify Your Skin Type) When I ask this extremely important question, particularly over the phone where I can not see anything and have to rely on only my customers communication skills, and the response I get is sensitive, I start to get a little frustrated when it is not followed immediately with a more detailed explanation.. Sensitive skin.. Do you think that because your skin is all red, raw and dried up from using every product in out acne line all at once that you have sensitive skin? Probably not. Skin is sometimes delicate and doesnt respond nicely to isopropyl alcohol, salicylic acid, glycolic acid, alpha hydroxy acid, granular scrubs and clay masks all on the same day. It does not always mean you have sensitive skin. It may just mean you have normal skin and you are treating it badly.. When you tell a skin care salesperson I have sensitive skin with no follow up info, assume they are ...
12 Sensitive Skin Tips 2020 - Expert Advice for Sensitive Skin
Dermatologists on the meaning of sensitive skin, best sensitive skin products, sensitive skin care tips, how to soothe irritated skin on the face, and more.
Sensitive Skin Care - how to articles from wikiHow
Learn everything you want about Sensitive Skin Care with the wikiHow Sensitive Skin Care Category. Learn about topics such as How to Wash Your Face when You Have a Sensitive Skin, How to Care for Sensitive Skin, How to Apply Eyeliner to Sensitive Eyes, and more with our helpful step-by-step instructions with photos and videos.
What Causes Sensitive Skin & Sensitive Skin Reactions | La Roche-Posay
What causes sensitive skin? Learn more about how to determine if you have sensitive skin and the factors that contribute to sensitive skin reactions.
Common antioxidant could slow symptoms of aging in human skin « Kurzweil
The researchers then used simulated human skin to perform several more experiments. This simulated skin - a three-dimensional model made of living skin cells - includes all the major layers and structures of skin tissue, with the exception of hair follicles and sweat glands. The model skin could also be used in skin irritation tests required by the Food and Drug Administration for the approval of new cosmetic products, Cao said.. This system allowed us to test a range of aging symptoms that we cant replicate in cultured cells alone, Cao said. Most surprisingly, we saw that model skin treated with methylene blue retained more water and increased in thickness-both of which are features typical of younger skin.. Formulating cosmetics. The researchers also used the model skin to test the safety of cosmetic creams with methylene blue added. The results suggest that methylene blue causes little to no irritation, even at high concentrations. Encouraged by these results, Cao and colleagues hope to ...
Mildness to skin - XCellR8
The reconstructed human epidermis ET50 method is a powerful tool for assessing the mildness of cosmetic ingredients or formulations in contact with the skin. Using an adaptation of a regulatory skin irritation test, subtle differences between mild and ultra-mild formulations can be measured, allowing a series of products to be placed into rank order of irritation potential (and therefore mildness). It provides a quick and cost-effective pre-screen, prior to human volunteer studies, driving key decisions in formulation development and providing valuable comparisons with industry benchmark products.. The test is commonly used to assess new baby formulations such as shampoos, foam baths and body washes, providing critical insights into the mildness of the product and comparisons with leading brands. It is highly relevant for a wide variety of other formulation types including facial soaps, cleansers and other skincare items.. The ET50 test also applies to cosmetic ingredients, such as assessment of ...
Guggul Lipid Regulator @ meds4everyone.com
Guggul Lipid Regulator @ Fast Delivery US | nest delivery USA | overnight delivery | overnight shipping | Fast Shipping USA | UK | AU | EU | CA @ Discounted Price
Test No. 228: Determination of Developmental Toxicity of a Test Chemical to Dipteran Dung Flies(Scathophaga stercoraria L. ...
This Test Guideline describes a method to estimate the developmental toxicity of a test chemical to the dung dwelling life stages of dung-dependent dipteran species. Two test species can be used. The test chemical is mixed with bovine faeces, to which either 10 eggs of Scathophaga stercoraria or 10 larvae of Musca autumnalis are added. The test will be terminated 5 days after emergence of the last adult in the control (> 18 days for S. stercoraria, >13 days for M. autumnalis). Then the possible impacts of the test chemical on the following measurement endpoints are assessed under controlled conditions: sex and total number of emerged adult flies, retardation of emergence indicated by the developmental rate and morphological change. Depending on the experimental design, the No Observed Effect Concentration (NOEC) or the Effect concentration for x percent effect (ECx) can be determined. This Guideline can be used for water soluble or insoluble substances, but is not
Cobalt - Registration Dossier - ECHA
Skin irritation Reference Heppenheimer (2010) is considered as the key study for skin irritation and will be used for classification. The mean relative absorbance (% of the negative control, correlating with mean tissue viability) after 15 minutes incubation in the in vitro human skin model test (EpiSkin, according to OECD TG 439) was 95.1%. The classification criteria according to regulation (EC) 1272/2008 as skin irritant are not met, since the mean tissue viability was above the threshold for skin irritants of 50.0%. No classification required. Eye irritation The references Heppenheimer (2011) and Mallaun (2011) are considered as the key studies for severe eye irritation and will be used for classification. According to Heppenheimer (2011) the mean in vitro score after 240 minutes incubation results of the in vitro bovine corneal opacity and permeability assay (BCOP, according to OECD TG 437) was 1.79. The value was below the threshold for severe eye irritants of 55.1. The classification ...
Buy Zirh Sensitive Skin Review by Hair Care Today
Sensitive skin is more prone to rashes and irritation caused due to shaving.Buy Zirh Sensitive Skin* and you can offer a desirable relief to your sensitive skin coupled with a smoother skin overall.
Barbasol Sensitive Skin Thick & Rich Shaving Cream for Men, 10 OZ
Barbasol Sensitive Skin Thick & Rich Shaving Cream for Men, 10 OZ |p|Barbasol Sensitive Skin Shaving Cream is specially formulated with aloe, thyme, papaya and willow bark and a light fragrance to hydrate and protect sensitive skin. The premium Close Shav
Formulation and evaluation of solid-lipid nanoparticle based 0.1% Soy isoflavone dermal gels
Solid - Lipid Nanoparticles (SLNs) based 0.1 % topical gel of soy isoflavones was formulated with the aim of better penetration through stratum cornea and efficient deposition of soy isoflavones in dermal matrix so as to aid in reversing postmenopausal skin aging. Isoflavoneaglycones were extracted from whole herbal soy extract and were characterized with respect to physical, spectral and antioxidant activity. SLNs prepared by microemulsion template technique were characterized by photon correlation spectroscopy for size and by Scanning Electron Microscopy for morphology. The nanoparticulate dispersion was suitably gelled and characterized with respect to pH, spreadability, rheology, drug content, in-vitro permeation using pig ear skin model and its safety was assessed using primary skin irritation studies. The developed SLN-based gel showed about 60% deposition of soy isoflavones in dermal matrix and showed no skin irritation on intact rabbit skin ...
Sensitive skin: tips and tricks
https://www.healthician.org/go/m501remedes.png The good gestures Sensitive skin is ultra-reactive and needs special attention if you want to avoid the risk of allergies. Discover all our tips to take care of sensitive skin. Do not do Begin by emptying your beauty cabinet and keep only one or two creams. Sensitive skin is very often allergic and only support a few specific products. Choose them rather unflavoured and hypoallergenic to limit the risks of allergy. Use gentle
Guggul Gum - An Extremely Powerful Herbal Supplement For Acne Yet A Mysterious One Too
Of those, weak digestion is the most interesting. Every acne clearing enthusiast needs an optimally functioning digestive system to 1) absorb vital acne vitamins and minerals from food, 2) prevent leaky gut syndrome, and 3) prevent an overly sensitive gut which reacts to innocent foods with random allergies that cause inflammation.. One scripture claims that guggul gum kindles agni, the digestive fire. There are few studies available on digestion, but one on mice above found that guggul gum reduced inflammation in the colon.. As for other areas of acne-related health, theres also evidence that guggul gum resin in its many forms is a decent source of antioxidants. The 1994 study on cholesterol above, the one which observed a 12.5% decrease in LDL, also observed a 33.3% decrease in overall oxidative stress. 33.3% is a pretty huge reduction in the overall quantity of free radicals floating around your bloodstream.. Guggul gum contains a wide variety of compounds as well as guggulsterone, ...
Does guggul herb help atherosclerosis | www.QACollections.com
On One Hand: Historically SuccessfulAyurveda, the classical Indian healing system, has endorsed Guggul's benefits for thousands of years. Ayurvedic physicians frequently prescribe the gum resin to patients suffering from atherosclerosis, a progressive hardening of the arteries. Guggul's potential to lower cholesterol levels may help prevent build-up of plaque, which contributes to the disease.On the Other: Insufficient Clinical EvidenceAccording to the University of Maryland Medical Center, Guggul may work less effectively for those who consume a standard, high-fat Western diet. Clinical studies regarding Guggul's effects on cholesterol le...
10 Common Skin Irritations - Which One Do You Have? - Leading your crusade to finding a Jock Itch cure - Jock Itch Crusader
Not sure if you have Jock Itch, Impetigo, Intertrigo, Psoriasis, Heat Rash, Dermatitis? Find out about skin irritations, and importantly...FIND RELIEF here!
Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin : lipid composition and thermal phase...
The present report is a part of our continuing efforts to explore the utility of the rat epidermal keratinocyte organotypic culture (ROC) as an alternative model to human skin in transdermal drug delivery and skin irritation studies of new chemical entities and formulations. The aim of the present study was to compare the stratum corneum lipid content of ROC with the corresponding material from human skin. The lipid composition was determined by thin-layer chromatography (TLC) and mass-spectrometry, and the thermal phase transitions of stratum corneum were studied by differential scanning calorimetry (DSC). All major lipid classes of the stratum corneum were present in ROC in a similar ratio as found in human stratum corneum. Compared to human skin, the level of non-hydroxyacid-sphingosine ceramide (NS) was increased in ROC, while alpha-hydroxyacid-phytosphingosine ceramide (AP) and non-hydroxyacid-phytosphingosine ceramides (NP) were absent. Also some alterations in fatty acid profiles of ROC ...
The development of T cell-dominated inflammatory responses induced by sodium lauryl sulphate in mouse oral mucosa | NIOM
The effect of a single time exposure of SLS to the buccal mucosa of mice was compared to one application of the hapten OXA (oxazolone), evaluated by routine histology, immunohistochemistry and ELISA quantifications of cytokines. The SLS concentrations (2%, 4% and 8%) resulted in epithelial surface necrosis at 1-6 h, after 2-6 h accumulation of intra-epithelial neutrophils and at 24 h the main inflammatory cells were mononuclear. Increased concentrations of SLS gave more severe damage. CD4(+) T cells were found at 6 h and increased slightly up to 24 h and were most frequently seen at the lowest SLS dose. The CD8(+) T cells were kept at a low number during the whole 24 h observation period, but increased proportionally to the CD4(+) T cells. One application of 1% OXA did not raise the number of cells of either phenotype (2-24 h). Neither IL-2 nor IFN-γ demonstrated increased levels during the week of observation at any concentration of SLS, contrary to one application of OXA which caused ...
MD7 Formulated for Sensitive Skins, Mineral Makeup Waterproof
MD-7 Cosmeceuticals Skin Care Solutions daily care products represent years of scientific research and development. Every ingredient is carefully chosen and is gentle enough for sensitive skin while being highly effective, hypo-allergenic, fragrance-free, free of dyes and color additives, free of harsh chemical preservatives, and free of other ingredients that are known to cause irritation or a sensitive skin reaction.
BLOG - Page 5 | Labcyte Inc.
Page 5 of Labcyte Blog articles covering the latest stories in Acoustic Liquid Handling for Drug Discovery, Cancer Research, and Genomics Research
BLOG - Page 5 | Labcyte Inc.
Page 5 of Labcyte Blog articles covering the latest stories in Acoustic Liquid Handling for Drug Discovery, Cancer Research, and Genomics Research
Vanicream Shave Cream, for Sensitive Skin | Walgreens
Vanicream Shave Cream, for Sensitive Skin at Walgreens. Get free shipping at $35 and view promotions and reviews for Vanicream Shave Cream, for Sensitive Skin
Barbasol Non-Aerosol Moisturizing Shave Cream for Men Sensitive Skin | Walgreens
Barbasol Non-Aerosol Moisturizing Shave Cream for Men Sensitive Skin at Walgreens. Get free shipping at $35 and view promotions and reviews for Barbasol Non-Aerosol Moisturizing Shave Cream for Men Sensitive Skin
Eucerin Everyday Protection Sensitive Skin Face Lotion Spf 30 $8.75 Gold Vitamin C | abc-nieruchomosci choices
Veja preo toxina botulinica quanto custa Botox e fotos antes depois no RJ. Nizona Corporation Japan. Eucerin Everyday Protection Sensitive Skin Face Lotion Spf 30 $8.75 Gold Vitamin C i have dry skin and tattoos.. Flawlessly camouflage skin concerns with our cream foundations liquid foundations and powder foundations. Any place youve recently gotten Botox or collagen injections in the last seven Hydrated skin can better handle acne and eakouts may occur. reviews on nivea hydro moisturizer injections vs elemis marine pro collagen cream reviews on elemis marine pro collagen cream Where to buy: Target Walmart CVS Walgreens. Cream of Broccoli Soup. Many celeities have become victims of plastic surgery gone wrong in their quest to enhance their looks. ALLURE MAGAZINES Best In Beauty Eye Gel - Its considered to be the most effective anti aging eye cream treatment available- designed to treat every major eye concern & is hands down the best eye Eucerin Everyday Protection Sensitive Skin Face Lotion ...
Nelaton Catheter Offered By Nanjing Kaihong Healthcare Co., Ltd. - Buying Medical and Health Products in China,B2B Marketplace...
the nelaton catheter manufactured from non-toxic, non-irritant medical grade PVC material the nelaton catheter manufactured from non-toxic, non-irritant medical grade PVC...,MEDinCN.com,The Largest China B2B Medical Products Marketplace
Skin Lotion, Gentle, Dry, Sensitive Skin - Wegmans
This product was formulated specifically for dry, sensitive skin. Contains extra-strength emollients and humectants to help prevent moisture loss. Provides long-lasting relief to even severe dry skin. Free of lanolins, parabens and fragrances that can irritate sensitive skin. Compare to ingredients of Cetaphil (This is not manufactured or distributed by Galderma Laboratories, Inc., distributor or Cetaphil). Quality guaranteed. This TopCare product is laboratory tested to guarantee its highest quality. Your total satisfaction is guaranteed.. ...
Purina Pro Plan Focus Sensitive Skin & Stomach Formula Salmon & Rice F - Concord Pet Foods & Supplies
Nurture your dogs sensitive skin and stomach with Purina Pro Plan FOCUS Sensitive Skin & Stomach Salmon & Rice Formula adult dry dog food. Nutrient-rich salmon is the first ingredient and a primary source of protein in this formula. Also containing prebiotic fiber, this dog food for sensitive stomach boasts a
Best Toilet Paper for Sensitive Skin | Tested and Reviewed by Expert - UnderDaRoof
Aww…thats an awkward question! But the sad reality is I know quite a few people who are suffering from this problem. So, if you have that extra sensitive skin you must be careful in choosing the toilet paper brand.. If your preferred tissue is colorful that means it is not chemical free. Besides, you may be a fan of the scented toilet paper which is not chemical free either. These chemicals have the potential to cause allergy to your skin. It is advisable to avoid such tissue brands if you have sensitive skin.. Manufacturing process of toilet tissue is a complex one where involvement of various chemical substances is almost inevitable. These chemicals are used to make toilet papers soft, strong and fluffy. Expensive brands use more chemicals-so, you know what I mean; it is probably a better choice to avoid those expensive brands if you are allergic to toilet papers.. What if you are already affected by allergy? Simple, stop using the toilet paper right now. Dont just rely on different ...
Antioxidant Hydrating Cleansing Mousse, Sensitive Skin Cleansers & Toners
Antioxidant Hydrating Cleansing Mousse, sensitive skin cleansers & toners, sensitive skin care, natural skincare products at auracosmetics.com superstore.
Sensibio Bioderma H2O for Sensitive Skin
Bioderma Sensibio H2O for Sensitive Skin is a cleansing and make-up removing water that respects the fragility of sensitive skin. It is the first and only micellar water that is perfectly compatible with the skin; its fatty acid esters, the constituent elements of micelles, are similar to the phospholipids of the skin cell membrane! This means that this product will naturally help to rebuild the skin while gently cleansing and removing make-up from your face and eyes. This product is fragrance, alcohol, and paraben-free while being hypoallergenic. This product has been a cult beauty favorite for years for a reason!. Benefits:. ...
Fallene Cotz Plus SPF 58 Water Resistant UVB/UVA Sunscreen for Sensitive Skin, 70ml Tube by Fallene - Shop Online for Beauty in...
Fishpond Australia, Fallene Cotz Plus SPF 58 Water Resistant UVB/UVA Sunscreen for Sensitive Skin, 70ml TubeBuy . Beauty online: Fallene Cotz Plus SPF 58 Water Resistant UVB/UVA Sunscreen for Sensitive Skin, 70ml Tube, Fishpond.com.au
Sensitive Skin Care Products
Many people have sensitive skin and should use discretion when switching makeup or facial products. Here are some tips for finding products for sensitive skin.
In 2009, the EU outlawed the use of animals in seven toxicity tests, including skin irritancy, sensitivity to light and genetic ... The types of tests performed on animals include acute toxicity testing, eye and skin irritation testing, skin sensitivity ... These may be alternative tests for animal testing or animal testing where there is no alternative under the law. Chemical ... testing, carcinogenicity testing and re-productivity and developmental toxicity testing. Numerous studies have shown that the ...
List of MeSH codes (E05)
... skin irritancy tests MeSH E05.940.560.150 - comet assay The list continues at List of MeSH codes (E06).. ... neutralization tests MeSH E05.196.922.750 - potentiometry MeSH E05.196.922.875 - skin test end-point titration MeSH E05.196. ... limulus test MeSH E05.200.875.220 - colony count, microbial MeSH E05.200.875.595 - microbial sensitivity tests MeSH E05.200. ... serum bactericidal test MeSH E05.337.550.600 - parasitic sensitivity tests MeSH E05.337.800.120 - adverse drug reaction ...
It also serves as a pH balancer in many different cosmetic products, ranging from cleansing creams and milks, skin lotions, eye ... A 2009 study stated that patch test reactions reveal a slight irritant potential instead of a true allergic response in several ... TEOA seems to be less potent in regard to systemic toxicity and RT irritancy than diethanolamine (DEA). Exposure to TEOA ... 2-3% in water TEOA is used as an corrosion inhibitor (anti-rust) agent in immersion ultrasonic testing. Triethanolamine, ...
Irritancy can be measured using the Draize test, where a test substance is applied to an animal's eyes or skin, usually an ... Over 20,000 rabbits were used for animal testing in the UK in 2004. Albino rabbits are used in eye irritancy tests (Draize test ... Such tests, which are still conducted in the U.S., involve general toxicity, eye and skin irritancy, phototoxicity (toxicity ... Toxicology testing, also known as safety testing, is conducted by pharmaceutical companies testing drugs, or by contract animal ...
In the Draize test for skin irritancy, the test substances are applied to skin that is shaved and abraded (several layers of ... Acute skin irritation and corrosive testing. OECD guidelines for testing of chemicals. Test guideline 404, Paris. Rodger D. ... the tests are now often referred to as "the Draize eye test" and "the Draize skin test". In 1971, before the implementation in ... Initially used for testing cosmetics, the procedure involves applying 0.5 mL or 0.5 g of a test substance to the eye or skin of ...
Alternatives to animal testing
Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another ... to fund work on a new humane skin test that could replace painful tests on mice and guinea pigs." Petition to the European ... OECD (26 June 2020). "Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" (PDF). OECD. doi: ... Skin irritation and skin corrosion refer to localized toxic effects resulting from a topical exposure of the skin to a ...
Sodium laureth sulfate
Nassif A, Chan SC, Storrs FJ, Hanifin JM (November 1994). "Abnormal skin irritancy in atopic dermatitis and in atopy without ... Tests in the US indicate that it is safe for consumer use. The Australian government's Department of Health and Ageing and its ... It has also been shown that SLES causes eye or skin irritation in experiments conducted on animals and humans. The related ... doi:10.1002/14356007.a25_747 NICNAS SLES animal test "Final report on the safety assessment of sodium laureth sulfate and ...
The latter being the possible skin irritancy (mechanical) whilst handling (1:1000). Flushing with cold water ... Colorimeters for solution tests which apply the Beer-Lambert law. Spectrophotometer to measure the concentrations of the lead ... On rapidly growing crops, tests have indicated that, while oxygen levels remain adequate, nitrogen may be depleted over the ... Using sheep wool resulted in the greatest yield out of the tested substrates, while application of a biostimulator consisting ...
The latter being the possible skin irritancy (mechanical) whilst handling (1:1000). Flushing with cold water ... Optimum nutrition concentrations for plant varieties are found empirically by experience and/or by plant tissue tests. ... Colorimeters for solution tests which apply the Beer-Lambert law.. Using chemical equipment for hydroponic solutions can be ... On rapidly growing crops, tests have indicated that, while oxygen levels remain adequate, nitrogen may be depleted over the ...
OTNE is classified as a skin irritant (R38 EU DSD, H315 EU CLP) and is positive in the Local Lymph Node Assay (LLNA - OECD 429 ... In a study with female mice, Iso E Super was positive in the local lymph node assay (LLNA) and irritancy assay (IRR), but ... Nov 1995), "Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis ... Its odour is long-lasting on skin and fabric. Iso E Super is a very common perfume ingredient, providing a sandalwood-like and ...
Route of administration
Intradermal, (into the skin itself) is used for skin testing some allergens, and also for mantoux test for tuberculosis. ... The chemical properties are solubility, stability, pH, irritancy etc. Site of desired action: the action may be localised and ... Epicutaneous (application onto the skin). It can be used both for local effect as in allergy testing and typical local ... Intralesional (into a skin lesion), is used for local skin lesions, e.g. acne medication. Intramuscular (into a muscle), e.g. ...
These materials are much milder to skin that other sulfate based surfactants (i.e. sodium lauryl sulfate) making them popular ... Tupker, R. A.; Bunte, E. E.; Fidler, V.; Wlechers, J. W.; Coenraads, P. J. (1999). "Irritancy ranking of anionic detergents ... using one-time occlusive, repeated occlusive and repeated open tests". Contact Dermatitis. 40 (6): 316-322. doi:10.1111/j.1600- ...
Route of administration
intradermal, (into the skin itself) is used for skin testing some allergens, and also for mantoux test for tuberculosis ... The chemical properties are solubility, stability, pH, irritancy etc.. *Site of desired action: the action may be localised and ... Subcutaneous (under the skin). This generally takes the form of subcutaneous injection, e.g. with insulin. Skin popping is ... epicutaneous (application onto the skin). It can be used both for local effect as in allergy testing and typical local ...
Nassif A, Chan SC, Storrs FJ, Hanifin JM (November 1994). "Abnormal skin irritancy in atopic dermatitis and in atopy without ... Testing cosmetic products on animals has been illegal in the European Union since September 2004, and testing the separate ... Cosmetics designed for skin care can be used to cleanse, exfoliate and protect the skin, as well as replenishing it, through ... They are usually applied to a cotton pad and wiped over the skin, but can be sprayed onto the skin from a spray bottle or ...
... and possibly laboratory tests. People with symptoms of early Lyme disease should have a total body skin examination for EM ... contact irritancy and acute toxicity of permethrin-treated clothing against nymphal Ixodes scapularis ticks". Ticks Tick Borne ... Blood tests are often negative in the early stages of the disease. Testing of individual ticks is not typically useful. ... As all people with later-stage infection will have a positive antibody test, simple blood tests can exclude Lyme disease as a ...
... skin and eye irritancy in rabbit and skin sensitization potential in guinea pig. Unpublished report from Shell Research Ltd, ... These data have been developed from lowest observed adverse effect levels (LOAEL) in test rats, based on adverse neurological ...
List of ASTM International standards (E)
Test Method for Heat of Ablation E459 - 05(2016) Test Method for Measuring Heat Transfer Rate Using a Thin-Skin Calorimeter ... 19 Test Method for Estimating Sensory Irritancy of Airborne Chemicals E982 - 94(2015) Specification for Laboratory Glass Test ... 14 Test Method for Recovery of Microorganisms From Skin using the Cup Scrub Technique E1875 - 20 Test Method for Dynamic ... 15 Test Method for Evaluation of Preoperative, Precatheterization, or Preinjection Skin Preparations E1174 - 13 Test Method for ...
Skin irritancy generally increases in the series non-ionic, amphoteric, anionic, cationic surfactants. ... Testing and inspection of diving cylinders *Hydrostatic test. *Sustained load cracking. *Diving regulator *Breathing ... Prolonged exposure to surfactants can irritate and damage the skin because surfactants disrupt the lipid membrane that protects ... and the application of medicinal lotions and sprays to surface of skin and mucous membranes. ...
New test eliminates need for skin irritancy tests on rabbits | Analytik NEWS
... tests, which take an important step towards ending the practice of using rabbits in skin and eye irritancy testing. These tests ... New test eliminates need for skin irritancy tests on rabbits. The Scientific Advisory Committee of European Centre for the ... One of the validated tests mimics human skin and predicts the skin irritancy potential of chemicals with great accuracy and ... The tests use in-vitro cell culture to evaluate the potential skin-irritancy of chemicals, by providing a realistic ...
Beware leakage from a smartphone case containing liquid - National Consumer Affairs Center of JAPAN
Test. (1) Irritancy to the skin. Encapsulated liquids of three brands turned out to have severe skin irritancy and skin ... Diagram 1: Evaluation of primary skin irritancy. Brands No.1-3 turned out to have severe skin irritancy and skin corrosivity ... As a result of the test, three brand liquids No.1-3 turned out to have severe skin irritancy: lesion in depth such as necrosis ... A primary skin irritation test was conducted to check if skin problems such as reddening and chemical burn could occur when the ...
Dried and irradiated skin equivalents for ready use - STRATATECH CORPORATION
... shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to ... Skin substitutes for irritancy testing. 2009-03-10. Comer. 7498167. Keratinocytes expressing exogenous angiogenic growth ... A "dried skin equivalent" is a skin equivalent from which moisture has been removed so that the dried skin equivalent has a ... In some embodiments, the skin equivalents are utilized to treat chronic skin wounds. Chronic skin wounds (e.g., venous ulcers, ...
Limited-Edition Lash Love Fanorama™ Mascara | I ♥ black | Mary Kay
Mary Kay® Hydrogel Eye Patches, pk./30 pairs | Mary Kay
Ophthalmologist-tested.. *Tested for skin irritancy and allergy.. *Non-comedogenic.. *Suitable for sensitive eyes and contact ... Based on bioinstrument testing. **Based on panelists who agreed with statements in a two-week independent consumer study in ... Place it on clean undereye skin, with the larger end of the patch toward the outer eye and the smaller end toward the nose. ... The patches use the moisturizing power of glycerin, a powerful humectant known to moisturize the skin and help with water loss ...
Limited-Edition Mary Kay Ultra Stay™ Lip Lacquer Kit | Cherry | Mary Kay
Dermatologist-tested. *Tested for skin irritancy and allergy. Limited Edition† Mary Kay Ultra Stay™ Lip Lacquer *Concentrated, ... A powerful humectant that acts like a sponge on your skin - helping to attract vital moisture so your skin can use it more ... Also includes moisturizing benefits that leave skin feeling soft and smooth. The lip lacquer eraser is formulated with known ...
TimeWise Repair® Volu-Firm® Advanced Lifting Serum | Mary Kay
Clinically tested for skin irritancy and allergy. *Suitable for contact lens wearers ... Using multiple clinical testing methods, including state-of-the-art 3D facial imaging, we tested TimeWise Repair® Volu-Firm® ... A skin-volume-supporting peptide helps maintain natural hyaluronic acid,†† a vital component of skin that plays a role in ... Skin moisture is immediately increased: 100%*. †Based on one 12-week independent clinical study in which 45 women used the ...
Buy Perfume-Free Bar Skin Cleansers | eBay
... s largest selection and best deals for Perfume-Free Bar Skin Cleansers. Shop with confidence on eBay! ... Suitable for sensitive skin. Clinically tested for skin irritancy and allergy. Oil- and fragrance-free. ... K MARY KAY 027914 SKIN CARE TIMEWISE 3 IN 1 CLEANSING BAR NORM, COMB, OILY SKIN. FOR NORMAL, COMBINATION AND OILY SKIN. 3 IN 1 ... 2 Bar Multipack CeraVe Fragrance Free Hydrating Cleanser Bar Dry to Normal Skin. For dry to normal skin. Item must be in NEW ...
Makeup by Isha Patel on Prezi
Animal Testing. Involves toxicity, eye and skin irritancy, phototoxicty, mutagencity. Animal testing is banned in India, Israel ... Cosmetics are often tested on smaller animals on specific parts. Some countries require mandatory animal testing. Then and Now ... Skin diseases, reactions, allergies Types of Cosmetics. Skin-care creams/lotions Powders. Perfumes. Lipsticks. Nail polish Eye ... From Renaissance period to 20th century, lower class women had darker skin, higher class women had paler skin. Higher class ...
The EPA National Library Catalog | EPA National Library Network | US EPA
A primary skin irritation test in rabbits (6/sex) showed no evidence of irritation; whether skin sites were abraded or intact ... No evidence of upper airway irritancy was seen. Washed and unwashed primary eye irritation studies were conducted in rabbits (6 ... Cyclohexane was tested for acute toxicity to rats (5/sex/group) exposed by inhalation to a nominal concentration of 32.88 mg/L ... A mouse lymphoma forward mutation assay conducted at test concentrations up to 100 ug/ml in the presence of S9 gave negative ...
DMSO Irritancy Assessed Using Noninvasive Methods | SpringerLink
... test is a quick and reliable test of the barrier function of the skin. In this study, in order to quantify the response, the ... The dimethylsulfoxide (DMSO) test is a quick and reliable test of the barrier function of the skin. In this study, in order to ... Frosch P, Duncan S, Kligman AM (1980) Cutaneous biometrics I. The response of human skin to dimethyl sulfoxide. Br J Dermatol ... Agner T., Serup J. (1989) DMSO Irritancy Assessed Using Noninvasive Methods. In: Frosch P., Dooms-Goossens A., Lachapelle JM., ...
Moisturizers - Bioelements skin care products
Skin becomes stronger, more comfortable and less reactive to daily stressors. Dermatologist tested for irritancy and ... Skin Biology Skin Source Skincerity / Nucerity Sothys St. Tropez StriVectin Suki Sundari Swissline Tend Skin Thalgo Tweezerman ... Beyond Hydration acts like a second skin to prevent moisture loss while maintaining skins water-to-oil balance. Its light, ... PSF Pure Skin Formulations RapidLash Raquel Welch RejudiCare Synergy Revale Skin Revision Skincare RevitaLash Rosebud Russell ...
Mary Kay Unlimited™ Lip Gloss | Copper Aura | Mary Kay
Mary Kay® Mineral Cheek Colour | Strawberry Cream
Clinically tested for skin irritancy & allergy.. *Dermatologist-tested and suitable for sensitive skin. ... Retinyl Palmitate (Vitamin A Palmitate) functions as a conditioner that helps improve the appearance of skin (e.g., skin looks ... Known as free radical scavengers, these ingredients are included in products to help protect the skin from the effects of free ... Known as free radical scavengers, these ingredients are included in products to help protect the skin from the effects of free ...
US9526811B2 - Dried and irradiated skin equivalents for ready use - Google Patents
In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin ... The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made ... Skin substitutes for irritancy testing WO2003093418A2 (en) 2002-04-30. 2003-11-13. Stratech Corporation. Keratinocytes ... A "dried skin equivalent" is a skin equivalent from which moisture has been removed so that the dried skin equivalent has a ...
Oligomerisation and alkylation reaction... - Registration Dossier - ECHA
There was no evidence for corrosivity in skin and eye irritancy testing. ... The test substance meets EU classification criteria for skin irritation.. Executive summary:. In a primary skin irritation/ ... induced reversible skin irritation in a skin irritation test according to OECD TG 404. Based on this result, the substance is ... There was no evidence of a corrosive effects on the skin.. Other effects:. Colouration: Remnants of the test substance were ...
Classic Basic® Deep Cleanser 3 | Mary Kay
Clinically tested for skin irritancy and allergy. Suitable for sensitive skin. Dermatologist-tested. ... Deep Cleanser 3 is designed for oily and/or blemish-prone skin to eliminate dirt and environmental elements which might clog ... Skin Care System 3 for oily and/or blemish-prone skin, helping to control oil breakthrough and shine to eliminate dirt and ... The unique formula in Classic Basic® Deep Cleanser 3 is designed for oily and/or blemish-prone skin to eliminate dirt and ...
Superdrug We Heart Pink Grapefruit Jelly Body Scrub 200ml | Superdrug
Test for irritancy first, Avoid direct contact with the eyes. If contact occurs, rinse thoroughly with clean water. Do not use ... Home , Skin , Body Care , Body Scrub , Superdrug We Heart Pink Grapefruit Jelly Body Scrub 200ml. ... You scrub up well! We love Pink Grapefruit Body Scrub; this refreshing blend will leave your skin smelling and feeling ... You scrub up well! We love Pink Grapefruit Body Scrub; this refreshing blend will leave your skin smelling and feeling ...
Alternatives to animal testing - Wikipedia
Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. Another ... to fund work on a new humane skin test that could replace painful tests on mice and guinea pigs." Petition to the European ... OECD (26 June 2020). "Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" (PDF). OECD. doi: ... Skin irritation and skin corrosion refer to localized toxic effects resulting from a topical exposure of the skin to a ...
2-hydroxypropyl)ammonium citrate - Registration Dossier - ECHA
The possible skin irritation potential of the test item was tested through topical application for 15 minutes. The test item ... The test item did not induce ocular irritation through both endpoints, resulting in a mean in vitro irritancy score of -2.1 ... Skin irritation/corrosion The ability of the test substance to induce induce skin irritation on a human three dimensional ... In conclusion, the test substance is non-irritant in the in vitro skin irritation test under the experimental conditions ...
RX List database - use generic or medication brand name - GlobalRPH
Cumulative irritancy testing revealed the potential for NAFTIN Gel to cause irritation. There was no evidence that NAFTIN Gel ... for 2 weeks to cover the affected skin areas plus a ½-inch margin of surrounding healthy skin. The most common adverse ... Apply a thin layer of NAFTIN Gel once daily to the affected areas plus an approximate ½ inch margin of healthy surrounding skin ... and one in vivo genotoxicity test (mouse bone marrow micronucleus assay). ...
10E)-1-oxacycloheptadec-10-en-2-one - Registration Dossier - ECHA
EpiDerm Skin Model (EPI-200, Lot no.: 22226 kit N). The test consists of topical application of the test item on the skin ... In vitro irritancy score (IVIS) = mean opacity value + (15 x mean OD490 value). A test item that induces an In Vitro Irritancy ... The test consists of topical application of the test item -one on the skin tissue for 15 minutes. After exposure the skin ... Test item: 50 µl of the undiluted test item was added into the 6-well plates on top of the skin tissues. Negative Control: ...
Indian Journal of Dermatology, Venereology and Leprology - A new occlusive patch test system comparable to IQ and Finn chambers
... testing plastic chamber material for its skin irritancy (iii) testing the assembled system against Finn, IQ and locally ... testing the plastic chamber material for its skin irritancy, and (iii) testing the assembled system against Finn, IQ and ... Skin irritancy testing of Chamber X material. There was no significant difference in ′′a′′ scores from baseline (P = 0.5), and ... All the tapes tested showed average irritancy scores below 2 and hence were classified as non-irritant. All the tapes tested ...
Mary Kay Cosmetics, Beauty - Make-Up Artist
Mary Kay products are tested for irritancy and allergy, are safe for sensitive skin and are non-comedogenic.. Among other ... Treat your skin to a new beginning with TIMEWISE.. Shop online with me at Its your source for finding everything you need to ... Youre invited To try the new generation in skin care products that give your face a second chance with special Anti-aging ...
Animal Testing Necessary Or Barbaric And Wrong? Discursive Essay. - 1508 Words - BrightKite
Animal testing has for a long time been a much debated moral i... ... Read this full essay on Animal Testing - Necessary or Barbaric ... skin) and ocular (eye) irritancy in products. When testing the dermal irritancy of a product on an animal, an area of the ... Two regular tests conducted are the LD50 test and Draize test. LD50 is a common animal test which stands for the. ... "Product Testing Toxic and Tragic") During the ocular test 100 milligrams of the concentrated solution of a test product are ...
Cruelty-free cosmetics - Wikipedia
In 2009, the EU outlawed the use of animals in seven toxicity tests, including skin irritancy, sensitivity to light and genetic ... The types of tests performed on animals include acute toxicity testing, eye and skin irritation testing, skin sensitivity ... These may be alternative tests for animal testing or animal testing where there is no alternative under the law. Chemical ... testing, carcinogenicity testing and re-productivity and developmental toxicity testing. Numerous studies have shown that the ...
Irritation testCorrosivityAllergyDermal irritancyAtopic DermatitisAssayCumulativeEfficacySensitivityChemicalsSensitizationAssessmentSuitableClinicallyMethodsToxicity testsDrynessCarcinogenicityBlindnessIngredientsClinicalProductsInduceTopicalOECDCorrosionExposureRednessIrritant DermatitisIrritantsBarrier functionEpidermisAssaysPotentialSurfactantsRabbitsInvolvesPredictAvoidSubstancesMary KayAlternativesAcuteHuman skinHydrationLaboratoryHumansStudiesMiceOilyIrritate the skinAnimalSensitiveSofterReactionsTissue viabilitySpecimensCommonly knownSeven volunteersMoisture
- The REACH Regulation currently foresees the rabbit skin irritation test for 10,000 chemicals which have already been on the market for more than 25 years. (analytik.news)
- A primary skin irritation test was conducted to check if skin problems such as reddening and chemical burn could occur when the liquid encapsulated in each specimen is attached to the skin (As for the detailed test method, see the reference material below). (go.jp)
- In conclusion, the test substance is non-irritant in the in vitro skin irritation test under the experimental conditions described. (europa.eu)
- The EpiDerm Skin Irritation Test was used to evaluate in vitro irritancy potential of OPA and glutaraldehyde. (cdc.gov)
- Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. (iivs.org)
- The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable. (iivs.org)
- Taken together the results indicate that the OS-REp test method can be used as a standalone alternative skin irritation test replacing the OECD test guideline 404. (norecopa.no)
- Despite scientific evidence regarding low predictivity and reproducibility this is still done by the Draize irritation test performed on rabbits, and it is estimated that more than 5000 rabbits are used annually for this test only in Europe. (forskautandjurforsok.se)
- An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model Helena Kandárová 1 , Patrick Hayden 1 , Mitchell Klausner 1 , Joseph Kubilus 1 , John Sheasgreen 1 1 MatTek Corporation In this video, we demonstrate the EpiDerm Skin Irritation test (EpiDerm SIT) developed and validated for in vitro skin irritation testing of chemicals, including cosmetic and pharmaceutical ingredients. (jove.com)
- No evidence for corrosivity in skin and eye irritancy testing. (europa.eu)
- A skin corrosivity test showed that thioacid is not corrosive to skin. (europa.eu)
- The European Centre for the Validation of Alternative Methods (ECVAM) is currently supporting formal validation studies of in vitro tests for predicting skin irritancy and corrosivity, including tests employing two human skin models, EPISKIN TM and EpiDerm TM . (or.jp)
- The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. (iivs.org)
- The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material. (iivs.org)
- Furthermore, a new validated test strategy for skin allergy cuts animal use by half saving up to 240,000 mice in the implementation of the REACH legislation. (analytik.news)
- Skin allergy is an occupational health problem which costs the European economy about 3 million work days every year - costing about €600 million. (analytik.news)
- Tested for skin irritancy and allergy. (marykay.com)
- Mary Kay products are tested for irritancy and allergy, are safe for sensitive skin and are non-comedogenic. (partypop.com)
- All basq products are rigorously tested for ZERO skin allergy and irritancy and is paraben, phthalate and animal-testing Free. (mommieswithstyle.com)
- the diagnosis is suggested by the distribution, severity, temporal association with certain activities and allergy testing as appropriate. (bpac.org.nz)
- We can also provide phototoxicity and photosensitisation screening to test for irritancy and/or allergy potential following exposures to UV light. (intertek.com)
- The results demonstrate the dermal irritancy and allergic potential of OPA and raise concern about the proposed/intended use of OPA as a safe alternative to glutaraldehyde. (cdc.gov)
- In conclusion, the study demonstrated significant reduction in dermal irritancy and tumorigenicity of Test CSC compared to Reference CSC. (sigmaaldrich.com)
- Many patients with eczema (atopic dermatitis) have an inherent defect in their skin barrier as demonstrated by high water loss. (clinicaltrials.gov)
- Epidermal Barrier integrity is deteriorated in many skin conditions, including Atopic Dermatitis, and could be responsible for many of the associated clinical symptoms. (scirp.org)
- People with a history of sensitive skin, hyperirritable skin and patients suffering from skin conditions such as atopic dermatitis (eczema), rosacea and psoriasis are best to avoid products containing SLS. (theconversation.com)
- A mouse lymphoma forward mutation assay conducted at test concentrations up to 100 ug/ml in the presence of S9 gave negative results. (epa.gov)
- Criterion 1 (negative control): The absolute OD 570 nm of the negative control tissues in the MTT test is an indicator of tissue viability obtained after the shipping and storing procedure and under specific conditions of the assay. (europa.eu)
- Each randomized subject will have a skin biopsy and skin irritancy assay performed prior to treatment and at the end of 12 weeks of treatment. (clinicaltrials.gov)
- To replace the Draize skin irritation assay (OECD guideline 404) several test methods based on reconstructed human epidermis (RHE) have been developed and were adopted in the OECD test guideline 439. (norecopa.no)
- Three assays were used in this assessment, a primary irritancy study, to screen for toxicity and determine the Minimal Irritating Concentration (MIC) and the Maximal Non- Irritating Concentration (MNC) and two assays, the Mouse Ear Swelling Test (MEST) and the Local Lymph Node Assay (LLNA), to test the dermal sensitizing potential of 2-ETAC. (nih.gov)
- Cumulative irritancy testing revealed the potential for NAFTIN Gel to cause irritation. (globalrph.com)
- CIR Safety Review: The CIR Expert Panel acknowledged that under the exaggerated exposure conditions of occlusive patch tests, Diethylhexyl Sodium Sulfosuccinate is a cumulative irritant, but not a sensitizer. (cosmeticsinfo.org)
- METHODS: In a randomized, double-blind, controlled trial, healthy volunteers were exposed to 5% SLS and 50% NON (the right and the left forearm, respectively) in a cumulative wash test. (druglib.com)
- Docusate sodium is also reported to be a cumulative skin irritant based on effects observed in human irritation and skin sensitisation studies. (tga.gov.au)
- In several four-day cumulative irritancy tests, application of products containing docusate sodium resulted in a primary irritation index (PII) range of 0.25-0.80 at 2.94% concentration, a PII range of 1.78-1.85 at 0.21% concentration and a PII of 0.04 at 0.084% concentration. (tga.gov.au)
- 9. The non-irritating photoprotective cosmetic composition of claim 1, wherein the photoprotective cosmetic composition has a Cumulative Irritation Total (CIT) score of less than 49 in a 14 day cumulative irritation evaluation or cumulativepatch test. (patentgenius.com)
- Intertek has a wealth of experience in safety evaluations including patch testing for primary irritation, cumulative irritation and sensitisation studies. (intertek.com)
- BioScience Laboratories Skin Technology Center performs clinical evaluations for cumulative skin irritation in accordance with the FDA/CDER Guidance for Industry, Skin Irritation and Sensitization Testing, December 1999. (biosciencelabs.com)
- The clinical efficacy of PIO will be assessed by quantifying the skin response to a model irritant, sodium lauryl sulphate (SLS) at several time points. (clinicaltrials.gov)
- The efficacy of ingredients or final formulations in modulating human skin pigmentation can be assessed in vitro by analysis of melanin production in reconstructed tissue models of various phototypes. (iivs.org)
- Applicability of an exaggerated forearm wash test for efficacy testing of two corticosteroids, tacrolimus and glycerol, in topical formulations against skin irritation induced by two different irritants. (druglib.com)
- Because the efficacy of different treatments in experimentally induced ICD may vary depending on the irritant applied, we tested the efficacy of four anti-irritant compounds using the two different irritants sodium lauryl sulfate (SLS) and nonanoic acid (NON). (druglib.com)
- Application of the present wash test as a tool for anti-irritant efficacy testing may be complicated by the small observed variance explained by treatment. (druglib.com)
- Products are tested on animals for three reasons: safety (this includes correct product labeling), efficacy and liability. (navs.org)
- Drugs intended for human or animal use are additionally tested for efficacy (i.e., effectiveness in treating a condition or disease). (navs.org)
- Rigorous dermatology studies are required to facilitate continual innovation to improve or introduce new skin care, cosmetic or beauty products to the market in order to assess their safety and efficacy. (intertek.com)
- Our dermatology trials for cosmetics are focused on supporting your product development through evidence-based dermatological efficacy testing and claims substantiation studies. (intertek.com)
- Our dermatology experts work to the European Cosmetic, Toiletry and Perfumery Association (COLIPA) guidelines including the Guidelines for the Evaluation of the Efficacy of Cosmetic Products, Guidelines on the Management of Undesirable Event Reports, Product Test Guidelines for the Assessment of Human Skin Compatibility and the Guidelines for the Safety Assessment of a Cosmetic Product. (intertek.com)
- Dermatologist tested for irritancy and sensitivity. (essentialdayspa.com)
- The types of tests performed on animals include acute toxicity testing, eye and skin irritation testing, skin sensitivity testing, carcinogenicity testing and re-productivity and developmental toxicity testing. (wikipedia.org)
- In 2009, the EU outlawed the use of animals in seven toxicity tests, including skin irritancy, sensitivity to light and genetic toxicity. (wikipedia.org)
- Because they have had this skin type from birth, they are usually aware of their sensitivity , as most have already experienced irritant and inflammatory issues with their skin before they even see a skin therapist. (skininc.com)
- Also, to understand skin's responses to such tests, e.g., irritation and sensitization (see Figure 1 ), an overview of the mechanisms involved and skin conditions affected by cosmetic products are described, including skin barrier function and variations in skin sensitivity linked to skin disease, body site, ethnicity and age. (cosmeticsandtoiletries.com)
- Existing estimates have varied in their interpretation of symptoms due to other causes and the case definition used, and they have assumed perfect test sensitivity and specificity. (bvsalud.org)
- These tests will apply to many everyday products such as washing-up liquid, face cream or make-up, and also literally thousands of industrial chemicals that will have to be assessed under the new REACH chemicals legislation. (analytik.news)
- One of the validated tests mimics human skin and predicts the skin irritancy potential of chemicals with great accuracy and precision and will therefore fully replace tests on rabbits. (analytik.news)
- The role of ECVAM, which is based at the European Commission's Joint Research Centre is to replace, refine and reduce methods of animal testing for cosmetics, drugs and chemicals. (analytik.news)
- The tests use in-vitro cell culture to evaluate the potential skin-irritancy of chemicals, by providing a realistic representation of the properties of human skin to identify irritant and non-irritant chemicals. (analytik.news)
- Potential skin irritants - such as cosmetics, cosmetic ingredients and all new chemicals - must be tested to ensure that they are labelled appropriately for the risk they pose to humans. (analytik.news)
- All 30.000 chemicals falling under the REACH legislation are therefore to be tested for skin allergies with a test using mice. (analytik.news)
- This policy is particularly relevant in the light of the latest amendment to the Cosmetics Directive, which will ban the testing of cosmetic ingredients on animals from 2009, as well as the forthcoming REACH Chemicals legislation, which comes into force on 1 June 2007. (analytik.news)
- For this reason, the skin is often exposed to potential y hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (such as irritant contact der- matitis and corrosion) to induction of immune-mediated responses (such as allergic contact dermatitis and pulmonary responses) or systemic toxicity (such as neurotoxicity and hepatotox- icity). (cdc.gov)
- Understanding the hazards related to skin contact with chemicals is a critical component of modern occupational safety and health programs. (cdc.gov)
- This document provides the scientific rationale and framework for the assignment of multiple hazard-specific skin notations (SK) that clearly distinguish between the systemic effects, direct (localized) effects, and immune-mediated responses caused by skin contact with chemicals. (cdc.gov)
- In meeting this objective, this Skin Notation Profile intends to inform the audience--mostly occupational health practitioners, researchers, policy- and decision-makers, employers, and workers in potential y hazardous workplaces--so that improved risk-manage- ment practices may be developed to better protect workers from the risks of skin contact with the chemicals of interest. (cdc.gov)
- 1990. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. (cdc.gov)
- In August 2010, the Organisation for Economic Co-operation and Development (OECD) published the Test Guideline 439 which describes the new procedure for in vitro hazard identification of irritant chemicals. (wikipedia.org)
- On the basis of peer review (ESAC, 2006) of the results of an inter-laboratory study (Kandarova et al, 2006) with the SkinEthic RHE Model, the ECVAM Scientific Advisory Committee (ESAC) endorsed the conclusion that the SkinEthic RHE Model can be used for distinguishing between skin corrosives and non-corrosive chemicals. (europa.eu)
- We evaluated the skin irritancy of 44 chemicals using the postincubation method (10-minutes treatment and 18-hours post-treatment incubation) that we originally developed to predict skin irritancy which is similar to a refined protocol for EPISKIN TM proposed in an ECVAM validation study. (or.jp)
- For example, the Draize Eye Test confines albino rabbits in stocks and drips chemicals into their forced-open eyes. (seacoastonline.com)
- Using animals to conduct safety testing is fraudulent science because differences between species and even between individual animals of the same species lead to unreliable test results due to variances in absorption, distribution, metabolism and excretion of chemicals. (seacoastonline.com)
- Toxicity tests to estimate the safety of products and chemicals were developed in the early 20th century. (navs.org)
- These include experiments that subjectively measure the irritation of chemicals in the eyes or on the skin of rabbits (the infamous Draize test), and lethal dose (LD50) experiments that determine toxicity by the dosage of a chemical that kills half of the animals forced to consume, breathe or be injected with that chemical. (navs.org)
- the Draize test"  Moreover, chemicals are currently not Draize tested on animals if they have already shown adverse effects in vitro  , thereby reducing the number and severity of tests carried out. (wikidoc.org)
- 5 studied damage to the skin barrier due to shaving in relation to the permeation of chemicals. (cosmeticsandtoiletries.com)
- There was no evidence that NAFTIN Gel causes contact sensitization, phototoxicity, or photoallergenicity in healthy skin. (globalrph.com)
- The purpose of these studies was to evaluate the irritancy and sensitization potential of OPA. (cdc.gov)
- A human sensitization test, a phototoxicity study, and a photoallergy study conducted in 38 male and 22 female volunteers showed no contact sensitization of the delayed hypersensitivity type, no phototoxicity and no photoallergenic potential due to ketoconazole 2% shampoo. (drugs.com)
- While a range of human and animal models for testing skin irritation exists, 3 the patch test remains the gold standard for the comparative evaluation of the irritation and sensitization potential of cosmetic products and ingredients. (cosmeticsandtoiletries.com)
- For example, human health endpoints evaluated in different types of toxicity tests include eye irritation, skin irritation, skin sensitization, carcinogenicity, genetic toxicity, neurotoxicity, reproductive toxicity and acute oral systemic toxicity. (navs.org)
- This data domain also includes studies that evaluate the potential for test articles to induce dermal sensitization (contact hypersensitivity) and irritancy following application to the skin. (healthdata.gov)
- Suitable for all skin types. (marykay.com)
- Suitable for sensitive skin. (ebay.co.uk)
- Dermatologist-tested and suitable for sensitive skin. (marykay.ca)
- When skin models are used to evaluate skin irritancy, it is important that suitable chemical application procedures are used. (or.jp)
- In addition, this testing platform is suitable for investigation of the dermal irritation potential of test materials after repeated exposures using a tissue viability endpoint. (iivs.org)
- The Scientific Advisory Committee of European Centre for the Validation of Alternative Methods (ECVAM) has today announced the validation of five new 'in-vitro' tests, which take an important step towards ending the practice of using rabbits in skin and eye irritancy testing. (analytik.news)
- The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. (freepatentsonline.com)
- In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. (freepatentsonline.com)
- Computational techniques, including predictive algorithms and mathematical models that describe a selected process (such as skin permeation) by means of analytical or numerical methods. (cdc.gov)
- Using multiple clinical testing methods, including state-of-the-art 3D facial imaging, we tested TimeWise Repair ® Volu-Firm ® Advanced Lifting Serum from every angle to show how it helps reclaim your triangle of youth. (marykay.com)
- Agner T., Serup J. (1989) DMSO Irritancy Assessed Using Noninvasive Methods. (springer.com)
- Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. (wikipedia.org)
- Several tissue culture methods that measure the rate of chemical absorption by the skin have been approved by the OECD. (wikipedia.org)
- Usually, once an experiment is complete, the animals involved are killed humanely, so as post-mortem examinations can be carried out.Most scientists would prefer to use non-animal methods, but often these just don't provide sufficient evidence as to what the effects on a living creature would be.The numbers of animals used in testing has greatly decreased in the past 30 years. (brightkite.com)
- This is because alternative methods have been developed and they have become more reliable.In some countries it is a legal requirement for a drug to be tested on animals before it is sold. (brightkite.com)
- The methods used to perform the tests have shocked the public and a collective desire to stop the treatment of animals, for the benefit of alternative experiments, such as in vitro tests, in silicon that requires no animal presence are now relevant. (wikipedia.org)
- There are many different methods for testing the mildness of personal care products, and numerous factors that can affect the data collected. (cosmeticsandtoiletries.com)
- provide a useful review of the development of patch test methods and the wide range of protocols and visual scoring methods used. (cosmeticsandtoiletries.com)
- 5 Their approach standardizes the number of panelists, the volume of the sample applied, the chambers used, the time points for skin evaluation, and the methods for grading skin reactions. (cosmeticsandtoiletries.com)
- however, physical and biophysical skin testing methods are also available. (cosmeticsandtoiletries.com)
- For example, toxicologists seeking more accurate or reliable methods have turned to cellular screening tests for many applications and have realized substantial savings in the process. (wildlife-rescue.org)
- Chapter 476 responds to this needless animal testing.12 It requires manufacturers and contract testing facilities13 to conduct alternative testing14 when certain *463 conditions are met: the alternative test methods must be scientifically approved and recommended by the federal Inter-Agency Coordinating Committee for the Validation of Alternative Methods15 (ICCVAM), and subsequently adopted by the appropriate federal regulatory agency. (animallaw.info)
- These primitive animal testing methods are, regrettably, still in use today. (navs.org)
- In addition, for each dollar Gillette spent during 1995 related to safety testing of personal care and consumer products, approximately 56 cents was for the development of in vitro testing methods, approximately 43 cents was for human clinical testing, and less than one cent of each dollar was spent on animal testing. (naiaonline.org)
- The following year Draize joined the FDA, and was soon promoted to head of the Dermal and Ocular Toxicity Branch where he was charged with developing methods for testing the side effects of cosmetic products. (wikidoc.org)
- Such protests are widely credited with encouraging cosmetics companies to replace the Draize eye test with in vitro methods, and in some cases, to discontinue animal testing altogether (Holden 1989). (wikidoc.org)
- However, all validated test methods in the guideline are linked to RHE provided by only three companies. (norecopa.no)
- Manufacturers are responsible for submitting safety test data to agencies, and this often involves conducting toxicity tests on the products and/or their ingredients before they enter the marketplace. (navs.org)
- Multiple toxicity tests are required to evaluate potential hazards for each product or chemical. (navs.org)
- After skin feels quenched, the patches help alleviate the feeling of dryness. (marykay.com)
- Extremely rich yet non-greasy creme that corrects dryness by saturating skin with a complex of natural emollients that trap moisture into surface layers. (essentialdayspa.com)
- High amount of alcohol damages skin and can make dryness worse! (beautypedia.com)
- However, a good number of dermatologist-approved cleansers help to address the oiliness and dryness of the skin. (cosmeticnews.com)
- Glycerin, which is the main ingredient in the wash, moisturizes the skin to reduce the dryness and dull skin patches. (cosmeticnews.com)
- Other research includes skin and eye irritancy tests (the infamous Draize Test), carcinogenicity (cancer) and mutagenicity (genetic mutation) studies, teratogenicity (birth defects) and reproductive toxicity studies, hepatotoxicity (liver damage) and nephrotoxicity (kidney damage) studies, neurotoxicity studies, etc. (envirolink.org)
- Initially for testing cosmetics, the procedure today typically involves applying 0.5 ml or 0.5 g of a test substance to an animal's eye or skin for four hours then observing the results for up to 14 days, for signs of erythema and edema in the skin test, and redness, swelling, discharge, ulceration, hemorrhaging, cloudiness, or blindness in the eyes. (wikidoc.org)
- The validation by ECVAM is an important step as it ensures that these tests can replace animal tests and at the same time provide the level of protection that consumers need against potentially harmful ingredients. (analytik.news)
- Known as free radical scavengers, these ingredients are included in products to help protect the skin from the effects of free radicals generated by the environment. (marykay.ca)
- However, in addition to the final product, most advocates for cruelty-free beauty agree that none of the ingredients used in the production of the cosmetics can be tested on animals in order to be cruelty-free. (wikipedia.org)
- This logo, valid in Europe and North America, certifies: the brand in its totality is cruelty free the absence of animal testing of the ingredients the absence of animal testing of finished products the absence of animal testing in foreign markets The label does not certify the absence of material of animal origin such as honey. (wikipedia.org)
- It certifies: the absence of animal testing of finished products the absence of animal testing of the ingredients the presence of organic natural ingredients (orange logo) the absence of material of animal origin except honey, pollen and beeswax This label was created by the International Association of Manufacturers against animal testing in cosmetics (IHTN). (wikipedia.org)
- It certifies: the absence of animal testing of finished products the absence of animal testing of the ingredients the raw materials of animal origin (egg, milk, honey) come from organic farming. (wikipedia.org)
- Bio-Oil contains numerous ingredients that help to plasticise the skin, making it softer, smoother and more supple, thereby reducing the appearance of wrinkled skin. (bio-oil.com)
- All ingredients are tested for adulteration and microbiological contamination prior to production and a sample from each batch manufactured is laboratory tested and then retained and monitored over a 5-year period. (bio-oil.com)
- Contains a smattering of skin-beneficial ingredients. (beautypedia.com)
- Currently, there are many alternatives to animal testing for cosmetic products and ingredients such as Epiocular, Episkin and Eyetex, to name a few. (seacoastonline.com)
- Reactive skin is not an official medical term, but is an esthetician-coined title that describes a skin that shows different types of reactions easily when exposed to certain products, ingredients, treatments or environmental factors. (skininc.com)
- The ingredients also have immense soothing potency that leaves the skin smooth, clean and relieved. (cosmeticnews.com)
- Product development/product stewardship scientists and formulators typically find it desirable to compare or rank order the skin irritation potential of candidate formulations, or to monitor the impact of changes in formulations or ingredients on skin tolerance. (iivs.org)
- Even after the company had ceased testing cosmetic products and ingredients on animals, PeTA kept up the assault. (naiaonline.org)
- Various federal laws covering product testing require animal tests for some ingredients and products and do not require them for others. (naiaonline.org)
- The Gillette Company has made considerable progress in reducing the use of animals in testing of over-the-counter drugs, has used no animals to test cosmetic ingredients or products for the past two years, and has been active in seeking alternatives to animal tests. (naiaonline.org)
- We, therefore, evaluated permethrin-treated clothing and formulated human skin repellent products, representing the six repellent active ingredients generally recommended for tick bite prevention by the Centers for Disease Control and Prevention (CDC), against H. longicornis nymphs from a colony established with adult ticks collected in New York state. (bvsalud.org)
- A clinical moisturizing treatment to target irritation and strengthen sensitive skin s barrier. (essentialdayspa.com)
- In situations where investigators look for inflammatory changes in skin that do not provide visible clinical irritation, more advanced techniques can be used. (cosmeticsandtoiletries.com)
- All animals underwent clinical evaluation on a slit lamp and the eyes were scored according to a modified Draize eye test and were histologically analyzed. (scielo.br)
- For drugs, agency approval to conduct human testing in clinical trials typically requires a company to submit the results from animal testing data and toxicity data. (navs.org)
- In clinical tests, on the application of undiluted oil to the skin of 30 subjects, there were no reports of skin irritancy. (akomaskincare.co.uk)
- These unique tools will help you assess current clinical practice, educate staff, customize and implement an evidence-based protocol, complete a performance improvement plan, and track progress on everything from skin breakdown, to staff compliance, to costs. (sageproducts.com)
- This test result is only related to products bought for the test. (go.jp)
- The substance oligomerisation and alkylation reaction products of 2-phenylpropene and phenol (OAPP) (previous name phenol, methylstyrenated) is a skin irritant, but it did not produce classifiable eye irritation when instilled into rabbit eyes. (europa.eu)
- The testing of cosmetic products directly onto an animal can be minimized or eliminated by the use of in Vitro cell growth and development. (wikipedia.org)
- You're invited To try the new generation in skin care products that give your face a second chance with special Anti-aging benefits for a healthier, younger-looking complexion. (partypop.com)
- Testing products on animal's can be fatal to the animals life. (brightkite.com)
- Since 2004, animal testing for finished products has been banned in the European Union. (wikipedia.org)
- In 2013 and 2016, the EU banned the import of cosmetic products tested on animals in its territory. (wikipedia.org)
- Some great products I've been testing from basq Skin Care have really perked up my spirits (and my skin). (mommieswithstyle.com)
- With more than 500 home and personal care companies now marketing products without testing on animals, it is hard to believe that some companies still use animals in painful tests. (seacoastonline.com)
- These clients seem to have a lot of problems finding products or treatments that don't cause problems for their skin. (skininc.com)
- We have reviewed our favourite products so you can read on to find the best face wash for combination skin and everything you need to know before buying the products. (cosmeticnews.com)
- Foremost, industry researchers need timely, accurate, cost-effective test results to help them get safer products to the marketplace. (iivs.org)
- Many manufacturers of personal care and cosmetic products expect (along with their customers) that their products will not irritate the skin. (iivs.org)
- Recent work at the author's company, shown here as a case study, has involved the development of mild body washes for sensitive skin, and examples of the tests used to describe the mildness of the products developed are given. (cosmeticsandtoiletries.com)
- Long before they appear on the shelves of your local supermarket, these products have gone through a long and complex testing process that leaves millions of animals mutilated, burned, poisoned and gassed in outmoded and unnecessary tests. (wildlife-rescue.org)
- However, the Food and Drug Administration (FDA) does urge companies to conduct whatever toxicological tests are appropriate to substantiate the safety of their products. (wildlife-rescue.org)
- Toxic products that have been tested on animals such as permanent wave solutions, oven cleaners, soaps and detergents are regularly introduced into the marketplace. (wildlife-rescue.org)
- That's because no amount of animal testing can change the fact that many of these products are harmful if ingested or used in a way not intended by the manufacturer. (wildlife-rescue.org)
- Despite the fact that they have been animal-tested, these products are no less deadly if a person eats or drinks them accidentally. (wildlife-rescue.org)
- The manufacturers of cosmetics and household products claim that they perform tests on animals to ensure the safety of their products under customary use or possible abuse when in reality it is to limit the company's liability to its customers in case of a lawsuit. (wildlife-rescue.org)
- Animal research has been used as an alternative method when the study of humans is deemed impractical or unethical, or when animal biology is of primary interest, and animals are frequently used in biological and medical research, in the testing of drugs and commercial products, and in educational exercises in the sciences. (wildlife-rescue.org)
- Lodén, M. (1995) Biophysical Properties of Dry Atopic and Normal Skin with Special Reference to Effects of Skin Care Products. (scirp.org)
- It is used in the formulation of a wide variety of topical products, including bath products, blushers, body and hand preparations, foundations, shaving creams and skin-care products. (cosmeticsinfo.org)
- The CIR Expert Panel stressed that care should be taken to avoid irritancy, especially in those products intended for prolonged contact with the skin. (cosmeticsinfo.org)
- What Products Are Tested and Regulated? (navs.org)
- The toxicity testing for many types of products still involves animal testing. (navs.org)
- Described in Table 1 below are some of the U.S. regulatory agencies that have regulations requiring data to support product labeling and safety, largely based on animal toxicity test data, before certain types of products can be put on the market. (navs.org)
- Many products undergo animal testing for safety to meet legal requirements to identify potential hazards to humans, animals and the environment. (navs.org)
- Even non-regulated products, such as cosmetics, are commonly animal-tested for safety for the purpose of liability . (navs.org)
- Earlier in 1996, PeTA filed a complaint with the FCC, alleging that Gillette falsely claimed that animal tests are required for certain of its products. (naiaonline.org)
- For example, companies must substantiate the safety of cosmetic products under a rule that does not explicitly require animal tests but does burden the company with the responsibility to make sure that the products are not hazardous to humans. (naiaonline.org)
- Animal testing is required for drug products covered by the FDA. (naiaonline.org)
- If you've ever Googled the causes of a skin complaint or damaged hair, chances are someone on the internet has pointed the finger at SLS, or sodium lauryl (or laureth) sulfate, a common ingredient in beauty products, washes, toothpastes and even cleaning products. (theconversation.com)
- That is, new products being tested to see how irritating they might be to human skin are compared to SLS - something we know definitely to be irritating. (theconversation.com)
- Generally, with consumer products such as washes that contain SLS, it's assumed they won't be on the skin for very long, meaning the chance of your skin being affected is pretty low. (theconversation.com)
- So products that will be on the skin for a prolonged time can contain no more than 0.05-2.5% SLS in most countries. (theconversation.com)
- The easiest and most common way to do this is to follow the internationally accepted standard series ISO 10993, describing what tests to perform for different types of products and in detail how it should be done. (forskautandjurforsok.se)
- Knowledge of the pH level of soaps and cleansers used by patients with atopic eczema and sensitive skin is crucial, as high-alkalinity products are irritants and impair the normal skin barrier, so interfering with the adequate control of atopic eczema. (scielo.org.za)
- [1,2] Knowing the pH levels of the soaps and cleansers used by patients with sensitive skin is crucial, as alkaline pH products are skin irritants. (scielo.org.za)
- The ability of the test substance to induce induce skin irritation on a human three dimensional epidermal model (EPISKIN Small model (EPISKIN-SMTM)) was evaluated in a GLP compliant study according to OECD 439 and EU B.46. (europa.eu)
- The eye hazard potential of the test substance was measured by its ability to induce opacity and increase permeability in an isolated bovine cornea in a GLP compliant study according to OECD 437. (europa.eu)
- The negative control responses for opacity and permeability were less than the upper limits of the laboratory historical range indicating that the negative control did not induce irritancy on the corneas. (europa.eu)
- The test item did not induce ocular irritation through both endpoints, resulting in a mean in vitro irritancy score of -2.1 after 10 minutes of treatment. (europa.eu)
- The high amount of alcohol present can induce free-radical damage, destroy elastin, impair skin's ability to heal, and increase inflammation, all of which add up to disaster for your skin! (beautypedia.com)
- SHetA2 (see structure in Fig. 1 A ) is such a compound because it did not activate retinoic acid receptor and retinoid X receptor receptors in receptor cotransfection assays and reporter cell lines ( 4 ), rescue or induce embryonic malformations in a RALDH knockout mouse model ( 5 ), or cause skin irritancy in a murine topical irritancy model ( 6 ). (aacrjournals.org)
- The possible skin irritation potential of the test item was tested through topical application for 15 minutes. (europa.eu)
- The possible corrosive potential of the test substance was tested through topical application for 3 minutes and 1 hour. (europa.eu)
- The eye damage of the test substance was tested through topical application for 10 minutes. (europa.eu)
- Skin irritation and skin corrosion refer to localized toxic effects resulting from a topical exposure of the skin to a substance. (wikipedia.org)
- Irritancy and allergic responses induced by topical application of ortho-phthalaldehyde. (cdc.gov)
- Female mice received a topical application of 7,12-dimehtylbenz(a)anthracene (DMBA) as the tumor initiator on the back skin during Week 1. (sigmaaldrich.com)
- SCORING SYSTEM: OECD 404: Grading of skin reactions and Draize et. (europa.eu)
- The substance was not irritating or corrosive to the skin in a GLP-compliant OECD 439 and 431 study. (europa.eu)
- The 3T3 Neutral Red Uptake (NRU) Phototoxicity Test, approved by the OECD, detects the viability of 3T3 cells after exposure to a chemical in the presence or absence of light. (wikipedia.org)
- some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers). (oecd.org)
- The participating laboratories used in-house generated OS-REp to assess the set of 20 reference substances according to the performance standards amending the OECD test guideline 439. (norecopa.no)
- In conclusion, the test substrate is not corrosive in the in vitro skin corrosion test under the experimental conditions described. (europa.eu)
- Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. (iivs.org)
- The key step within assignment of the hazard-specific SK is the determination of the hazard potential of the substance, or its potential for causing adverse health effects as a result of skin exposure. (cdc.gov)
- Cyclohexane was tested for acute toxicity to rats (5/sex/group) exposed by inhalation to a nominal concentration of 32.88 mg/L. Exposure-related increased incidence of tremors, hyperactivity, rapid respiration, and prostration were noted in both sexes. (epa.gov)
- Skin irritation is expressed as the remaining cell viability after exposure to the test item. (europa.eu)
- If this weren't bad enough, exposure to alcohol actually causes skin cells to self-destruct ( Alcohol, 2002 ). (beautypedia.com)
- Normalization of pigment following successful therapy is variable and may take months, depending on individual skin type and incidental skin exposure. (drugs.com)
- Test materials that are phototoxic can produce adverse effects in the presence of light after exposure. (iivs.org)
- Contact dermatitis is the medical term used to describe skin reactions resulting from exposure either to irritants, i.e., irritant contact dermatitis (ICD), or allergens, i.e., allergic contact dermatitis (ACD). (cosmeticsandtoiletries.com)
- The exact tests required can differ according to regulatory agency, product type and intended use/potential exposure. (navs.org)
- This work culminated in a report by Draize, his laboratory assistant, Geoffrey Woodard, and division chief, Herbert Calvery, describing how to assess acute, intermediate, and chronic exposure to cosmetics by applying compounds to the skin, penis, and eyes of rabbits (Draize et al 1944). (wikidoc.org)
- Examples of endpoints: proliferative responses in the lymph nodes that drain the site of test article application and measurements of edema at the site of exposure. (healthdata.gov)
- Occupational exposure to these compounds occurs primarily by inhalation or skin exposure. (nih.gov)
- With redness-reducing natural plant glucosides and ceramides, to diminish signs of overactive skin. (essentialdayspa.com)
- With therapeutic aloe vera and chamomile, plus deeply moisturizing and barrier strengthening Chinese medicinal silver ear mushroom to comfort, reduce visible redness, and calm reactive skin. (essentialdayspa.com)
- Redness is reduced and skin is encouraged to build up the protective barrier it needs to defend itself against environmental irritants. (essentialdayspa.com)
- Reactive skin may include genetically sensitive skin , acne-prone skin, skin with allergies, irritant reactions, ingredient sensitivities, rosacea and redness-prone clients. (skininc.com)
- True sensitive skin is attributable to genetics and characterized by a history of histamine reactions causing such symptoms as urticaria (hives), erythema (redness), edema (swelling), rashes, as well as subjective symptoms such as itching, stinging and burning. (skininc.com)
- Contact irritant dermatitis can be subdivided into subjective irritancy (stinging within minutes of contact, without objective findings), acute contact irritant dermatitis (a chemical burn) and chronic contact irritant dermatitis (when physical or chemical damage overwhelms the skin's repair mechanisms). (bpac.org.nz)
- Two other tests can identify severe eye irritants, thereby avoiding the need to use the live rabbit eye test. (analytik.news)
- Two other tests validated today will identify eye irritants using tissues from slaughter-houses, which would otherwise be discarded. (analytik.news)
- Here again, the test will replace the use of animals to identify severe irritants, though some animal testing will still be required for mild irritants. (analytik.news)
- The dimethylsulfoxide (DMSO) test is a quick and reliable test of the barrier function of the skin. (springer.com)
- In laboratory conditions, studies have shown that pioglitazone restores the skin barrier function in skin from eczema patients. (clinicaltrials.gov)
- The purpose of this study is to determine if taking pioglitazone improves the skin barrier function in people with eczema. (clinicaltrials.gov)
- 5.0 is in a better condition regarding the skin barrier function, moisturisation and scaling. (scielo.org.za)
- In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" (06 July 2012). (europa.eu)
- The aim of this study was to determine the effect of REPAVAR ATOPIC SKIN BODY CREAM EXTREME, product containing "SKIN CALM COMPLEX" on barrier epidermis structure. (scirp.org)
- To overcome this limitation and thus to increase the accessibility of in vitro skin irritation testing, an open source reconstructed epidermis (OS-REp) was introduced. (norecopa.no)
- Although other in vitro assays can predict irritancy vs. non-irritancy for purposes of regulatory compliance, many of. (iivs.org)
- The potential risk to skin is even greater because of the inclusion of potentially irritating fragrance, which can speed up the signs of aging via inflammation (see More Info). (beautypedia.com)
- An exaggerated use washing test on the sensitive antecubital skin of 10 subjects twice daily for five consecutive days showed that the irritancy potential of ketoconazole 2% shampoo was significantly less than that of 2.5% selenium sulfide shampoo. (drugs.com)
- Immunotoxicology identifies the potential for a test article to modulate immune function in mice and/or rats. (healthdata.gov)
- This education section will help you address patient skin integrity issues, eliminate potential bath water contamination, and empower all levels of staff to observe and report changes during daily bathing. (sageproducts.com)
- Disclosed is an ultra mild skin cleansing composition comprising: mild synthetic surfactants, moisturizers, polymeric skin feel and mildness aids and selected levels of soap. (google.com.au)
- The CIR Expert Panel recognized that under exaggerated test conditions, surfactants would be expected to produce some irritation. (cosmeticsinfo.org)
- And some surfactants are more irritating to our skin than others. (theconversation.com)
- All such testing is currently carried out on animals - approximately 20,000 per year, predominantly rabbits. (analytik.news)
- Skin irritancy tests clam noxious substances on the bare skin of rabbits, rats and mice, with observation made of irritation such as swelling, itching, soreness and inflammation. (seacoastonline.com)
- As a result, millions of rabbits and other animals continue to be the innocent victims of painful eye and skin irritancy tests. (wildlife-rescue.org)
- Most animal testing for toxicity is conducted using mice, rats and rabbits. (navs.org)
- It usually involves the application of a product or solution to the skin, under occlusion, and the visual grading of the irritant response. (cosmeticsandtoiletries.com)
- This testing typically involves animal models as well. (navs.org)
- The Draize test involves placing a small volume of the substance into one eye of each rabbit in a small group of animals (typically three to six), and then recording specific effects observed in that eye over time (typically up to 21 days). (navs.org)
- Vitrolife-Skin TM showed a basic utility for irritancy testing by this method and it is possible to confidently predict skin irritancy, provided that an appropriate chemical application procedure is used. (or.jp)
- However, this maintaining of the status quo ignores the failure of animal tests to predict what is safe or effective in people while failing to recognize the advances made in non-animal testing methodologies . (navs.org)
- Perhaps the most commonly known method of animal testing for toxicity is the Draize rabbit eye test, intended to predict whether a product or chemical would cause injury to the human eye. (navs.org)
- Accordingly, NCAC examined skin irritancy of chemical liquids encapsulated in some smartphone cases, and decided to issue an alert to consumers to avoid recurrence of similar problems. (go.jp)
- Test for irritancy first, Avoid direct contact with the eyes. (superdrug.com)
- The shocking conditions of animal experiments has prompted cosmetic consumers and beauty industry professionals to avoid animal testing and to look for new alternatives. (wikipedia.org)
- 4 (Avoid contact with skin). (tga.gov.au)
- And since all the other substances were tested at either 5% or 2%, the relative risk of each cannot be compared anyway. (personalcaretruth.com)
- In 1971, toxicologists Carrol Weil and Robert Scala of Carnegie Mellon University distributed three test substances for comparative analysis to 24 different university and state laboratories. (wikidoc.org)
- Due to its controversial nature, the use of the Draize test in the U.S. and Europe has declined in recent years and is sometimes modified so that anaesthetics are administered and lower doses of the test substances used. (wikidoc.org)
- The goal is to develop a platform to test substances that could become drugs against Alzheimer's and other neurodegenerative diseases. (forskautandjurforsok.se)
- Mary Kay® Deep Cleanser 3 is a strategic part of the Mary Kay® Classic Basic® Skin Care System 3 for oily and/or blemish-prone skin, helping to control oil breakthrough and shine to eliminate dirt and environmental elements which might clog pores. (marykay.de)
- Animal test alternatives: Refinement, reduction, replacement. (cdc.gov)
- Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation. (wikipedia.org)
- Other alternatives include the use of humans for skin irritancy tests and donated human blood for pyrogenicity studies. (wikipedia.org)
- Numerous studies have shown that the effectiveness of these tests are limited, and valid alternatives exist for many of these tests. (wikipedia.org)
- Human cell cultures and tissue studies, in-vitro tests, and artificial human "skin" and "eyes" mimic the body's natural properties and provide scientists with less-expensive alternatives to animal tests. (seacoastonline.com)
- Today, in response to pressure from the public and animal advocacy groups, many large consumer product companies have discontinued animal testing in favor of nonanimal alternatives. (wildlife-rescue.org)
- The company denied that it had declared a moratorium on testing but instead was working towards replacing animal tests with alternatives where possible. (naiaonline.org)
- Gillette does fund research to alternatives to animals testing," said company spokesman Danielle Frizzi. (naiaonline.org)
- In spite of the company's record in reducing animal testing, its efforts in funding development of alternatives, and the specific requirements to test imposed by the federal government, PeTA has continued its high-profile campaign against Gillette. (naiaonline.org)
- Environmental Protection Agency Health Effects Test Guidelines OPPTS 870.2400 Acute Eye Irritation, Aug. 1998. (patentgenius.com)
- In addition, rabbit skin does not always react in the same way as human skin. (analytik.news)
- It will now be possible to replace these with the new tests using human skin grown in the laboratory. (analytik.news)
- Frosch P, Duncan S, Kligman AM (1980) Cutaneous biometrics I. The response of human skin to dimethyl sulfoxide. (springer.com)
- Human skin equivalent tests can be used to replace animal-based corrosive and irritative studies. (wikipedia.org)
- EpiDerm from Mattek and EpiSkin and SkinEthic RHE model are derived from human skin cells which have been cultured to produce a model of human skin. (wikipedia.org)
- and wherein the amount of the nonpolar, nonvolatile solvent is such that the transdermal flux rate of the salt of the amine, when applied to human skin in the solvent, is at least 50% that of the uncomplexed, unsolvated physiologically active amine. (google.com)
- Validation studies have shown that tests employing human skin models are able to reliably distinguish between known skin corrosives and non-corrosives (Botham et al, 1995, Barratt et al, 1998 and Fentem et al, 1998). (europa.eu)
- SLS is a known irritant to human skin. (theconversation.com)
- It has to have been found in studies to irritate human skin, and it has to have the ability to penetrate the skin. (theconversation.com)
- So if it's known to be irritating to human skin, why don't the regulatory authorities ban its use? (theconversation.com)
- The use of detergents to clean human skin is a widespread phenomenon. (scielo.org.za)
- Reluctance of H. longicornis nymphs to stay in contact with nontreated human skin precluded the use of a human skin bioassay to optimally evaluate repellency. (bvsalud.org)
- This whipped blend of moisture-locking hyaluronic acid plus Chinese silver ear mushroom push comforting hydration deep into skin, to protect against inflammation and help restore barrier damage. (essentialdayspa.com)
- Beyond Hydration acts like a 'second skin' to prevent moisture loss while maintaining skin's water-to-oil balance. (essentialdayspa.com)
- The likelihood of developing stretch marks varies according to skin type, race, age, diet and hydration of the skin. (bio-oil.com)
- On the other hand, if they wish to prove that the same chemical is a carcinogen, they produce other laboratory tests that show the product to be carcinogenic. (envirolink.org)
- The within-laboratory reproducibility of 87% and the inter-laboratory reproducibility of 85% prove a high reliability of irritancy testing using the OS-REp protocol. (norecopa.no)
- Manuka oil has been shown to be effective in laboratory tests against 39 separate micro-organisms, and, in particular, against streptococci and staphylococcal bacteria and pathogenic fungi that affect the skin - such as ringworm, tinea (athlete's foot) and candida albicans/thrush. (akomaskincare.co.uk)
- Testing anything on animals, and putting them at harm, for this animal testing should be outlawed.If you think that animal testing is an effective way to give humans accurate results on whether a product will harm us or not, well think again. (brightkite.com)
- Many health charities fund tests on animals that include starving, crippling, burning, poisoning and cutting animals open to study diseases that affect humans, not animals. (seacoastonline.com)
- No skin or eye-irritating effects were noted in in-vitro studies. (europa.eu)
- This dataset also comprises studies that assess the ability of test articles to trigger or modulate existing autoimmunity. (healthdata.gov)
- For irritancy testing, in two separate studies, nine mice each were used to test four concentrations of test article in vehicle plus vehicle and untreated controls. (nih.gov)
- The unique formula in Classic Basic® Deep Cleanser 3 is designed for oily and/or blemish-prone skin to eliminate dirt and environmental elements which might clog pores. (marykay.de)
- Revisiting this article almost three decades later, many clients still have oily skin, clog-prone and acne-prone skin. (skininc.com)
- Combination skin means that you are dealing with both oily and dry skin. (cosmeticnews.com)
- When we use a wash or beauty product on our skin, it's probably a liquid made of a water phase and an oily phase. (theconversation.com)
- To treat oily skin, acne, and spots: wash affected area, and apply the pure oil with a cotton wool ball. (akomaskincare.co.uk)
Irritate the skin1
- The formula, also infused with Japanese Skin Purifying Technology does not irritate the skin and only targets impurities, oil and dirt. (cosmeticnews.com)
- These tests, validated by a committee composed of nominees from the EU Member States, industry, academia and animal welfare, must now be accepted by regulatory authorities and in the Member States. (analytik.news)
- However, not only are such rabbit tests unsatisfactory from an animal welfare point of view, their scientific quality is also questionable. (analytik.news)
- A gauze patch evenly moistened with the liquid encapsulated in each specimen was applied to the intact skin of each test animal for 4 hours. (go.jp)
- Prokaryotes are often used as an alternative to animal testing. (wikipedia.org)
- Fungi is also used as an alternative for animal testing. (wikipedia.org)
- Animal Testing Necessary Or Barbaric And Wrong? (brightkite.com)
- Animal testing has for a long time been a much debated moral issue. (brightkite.com)
- why can't people agree on the subject of animal testing? (brightkite.com)
- However, the argument for animal testing is also legitimate. (brightkite.com)
- Animal testing can help scientists find side effects, medicines, even cures. (brightkite.com)
- 785 words - 4 pages Is animal testing wrong? (brightkite.com)
- In my opinion, I think that animal testing is completely out of order. (brightkite.com)
- Animal testing is plainly unnecessary and downright cruel. (brightkite.com)
- Vivisection can be defined as an invasive experiment performed on an animal for the purpose of scientific research, product testing or education ("The National. (brightkite.com)
- Faced with this plague, the authorities of several nations have reviewed their legislation to limit the use of animal testing in the cosmetics sector. (wikipedia.org)
- Animal Test. (or.jp)
- For example, if they want to 'prove' that a particular chemical is not a carcinogen, all they have to do is present the evidence from those animal tests that supports this view. (envirolink.org)
- Virtually all of them have been animal-tested at various stages of their development. (wildlife-rescue.org)
- It is believed that the law requires animal testing on cosmetics. (wildlife-rescue.org)
- Animal testing on cosmetics is not required by the federal Food, Drug and Cosmetic Act. (wildlife-rescue.org)
- Animal testing merely determines the level of toxicity. (wildlife-rescue.org)
- Still, animal testing remains an accepted practice for many of the largest companies, despite its serious limitations in assuring the health and safety of American consumers. (wildlife-rescue.org)
- The article examines animal testing by providing detailed background information on toxicity testing, product injury and consumer safety, and alternative testing. (animallaw.info)
- In addition, the article provides information regarding the agencies that oversee animal testing. (animallaw.info)
- Finally, the article analyzes federal and state laws that exist to monitor animal testing, specifically focusing on California legislation. (animallaw.info)
- When I say I'm against animal testing, I sometimes get some very vehement responses from people saying if abolishing animal testing means those tests are going to be carried out on people, then they're for keeping the animal testing. (bayareaveg.org)
- Being a nurse, and working in the hiv/aids field, I come across this a fair amount when I bring up my objections to animal testing. (bayareaveg.org)
- Even one of our consulting doctors, who used to be a great admirer of Henry Spira, has said at a staff meeting that some animal testing is still necessary. (bayareaveg.org)
- Accordingly, SHetA2 lacks conventional retinoid toxicities, such as skin irritation or teratogenecity, when tested in animal models ( 5 , 6 ). (aacrjournals.org)
- Many scientists continue to rely on animal testing, and regulatory agencies still mandate data collected from animal experiments, in large part because that is what tradition and current laws dictate. (navs.org)
- Each test is based on a human health endpoint that is to be evaluated in the animal model. (navs.org)
- Then, abruptly, in mid-December, the animal rights organization cited a "moratorium" on testing at Gillette and backed off. (naiaonline.org)
- At present, the only tests available to do the job are animal-based tests according to the company and to the US Food and Drug Administration. (naiaonline.org)
- Since 1991, animal testing has never exceeded six percent of the total safety expenditures for the company. (naiaonline.org)
- The Draize Test is an animal test devised in 1944 by Food and Drug Administration (FDA) toxicologist John H. Draize and coworkers. (wikidoc.org)
- The tests are controversial, considered by some to be an example of animal cruelty , as well as unscientific because of the differences between rabbit and human eyes, and because of the subjective nature of the visual evaluations. (wikidoc.org)
- This is the last step required before the test method can be formally accepted and included in the standard series, so that the animal testing can be stopped without hampering the development of novel medical devices. (forskautandjurforsok.se)
- A soothing face mist to leave sensitive skin nourished, hydrated and protected. (essentialdayspa.com)
- Do not use on broken, irritated or sensitive skin. (superdrug.com)
- While many clients will tell you they have sensitive skin, the truth is that most people do not have sensitive skin. (skininc.com)
- Instead, they have had some sort of reactive issue to a product in the past and believe that their skin is sensitive. (skininc.com)
- Clients also often say they have sensitive skin, when they really have acne-prone skin. (skininc.com)
- They break out in acne flares or have a tendency to have congested pores, but they have erroneously labeled this to be sensitive skin. (skininc.com)
- They may have overused an exfoliating product such as benzoyl peroxide, had an irritant reaction and now believe they have sensitive skin. (skininc.com)
- The immune response of this sensitive skin causes the release of histamines and increased blood flow to the area, resulting in the symptoms discussed above. (skininc.com)
- Sensitive skin is thin to the look and touch. (skininc.com)
- Clients with reactive sensitive skin often have Fitzpatrick Type I skin. (skininc.com)
- The cleansers also work well with sensitive skin types, which is another outcome of having a combination skin type. (cosmeticnews.com)
- It does not tamper with the skins natural moisture and it is ideal for even those with sensitive skin. (cosmeticnews.com)
- The chill-out cleanser penetrates deep into the pores without causing any irritations to the skin and it is ideal for all kinds of combination, sensitive and normal skin types. (cosmeticnews.com)
- The aim of this study was to assess the pH of various bar soaps and cleansers that are usually recommended and used by patients with atopic diseases and dry, sensitive skin in South Africa. (scielo.org.za)
- Retinyl Palmitate (Vitamin A Palmitate) functions as a conditioner that helps improve the appearance of skin (e.g., skin looks softer, smoother, etc.) or hair. (marykay.ca)
- Superdrug recommends using your Body Scrub a few times a week for softer skin! (superdrug.com)
- In one week, the cleanser refreshes and softens the skin giving it a healthier, softer, subtle and better look. (cosmeticnews.com)
- The higher the test concentration, the greater will be the number of reactions. (personalcaretruth.com)
- When 50 healthy volunteers were patch tested with the undiluted oil, there were no reactions (Meneghini et al 1971). (personalcaretruth.com)
- Tested at 1%, lavender oil produced no reactions in 273 dermatitis patients (Meneghini et al 1971). (personalcaretruth.com)
- Because of their skin thinness, exfoliants and peels can sometimes wreak havoc with irritant reactions. (skininc.com)
- Intense local inflammatory reactions can occur (e.g., skin weeping, erosion). (nih.gov)
- Since the mean relative tissue viability for the test item was above 50% after 15 ± 0.5 minutes treatment the test item is considered to be non-irritant. (europa.eu)
- The relative mean tissue viability obtained after 3-minute and 1-hour treatments with the test item compared to the negative control tissues was 78% and 85%, respectively. (europa.eu)
- Because the mean relative tissue viability for the test item was not below 50% after the 3-minute treatment and not below 15% after the 1-hour treatment the test item is considered to be not corrosive. (europa.eu)
- The integrity of the skin barrier will be assessed in the lab by transepithelial electrical resistance (TEER) and permeability of the biopsy specimens. (clinicaltrials.gov)
- By Draize's retirement in 1963, and despite never having personally attached his name to any technique, irritancy procedures were commonly known as "the Draize test" (Kay and Calandra 1962). (wikidoc.org)
- Another study , on seven volunteers over a three and a half month period, found regular contact caused irritation, and the irritation subsided once the skin was no longer exposed to SLS. (theconversation.com)
- A powerful humectant that acts like a sponge on your skin - helping to attract vital moisture so your skin can use it more effectively. (marykay.com)
- More than a moisturizer, Remineralist Daily Moisture is a lightweight lotion created to help skin protect itself from daily atmospheric stressors. (essentialdayspa.com)
- A super-hydrating serum that binds moisture to surface skin layers, counteracting the effects of dry indoor heat, low humidity or chronic dry skin. (essentialdayspa.com)
- This next-generation gloss glides on smoothly with no drag and delivers instant moisture, thanks in part to vitamins C and E. Choose from 14 shades that work for every skin tone and any occasion, perfect for whatever your lips face next. (marykay.ca)
- The surface of the skin has an invisible oil layer which acts as a barrier to stop moisture from escaping. (bio-oil.com)
- In a very dry climate this lipid layer is often unable to cope and too much moisture is drawn out of the skin. (bio-oil.com)