Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.Skin DiseasesSkin Neoplasms: Tumors or cancer of the SKIN.Skin Physiological Phenomena: The functions of the skin in the human and animal body. It includes the pigmentation of the skin.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Skin Absorption: Uptake of substances through the SKIN.Skin Pigmentation: Coloration of the skin.Skin, Artificial: Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.Skin Diseases, Bacterial: Skin diseases caused by bacteria.Skin UlcerEpidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Skin Abnormalities: Congenital structural abnormalities of the skin.Staphylococcal Skin Infections: Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.Dermatitis: Any inflammation of the skin.Dermatologic Surgical Procedures: Operative procedures performed on the SKIN.Skin Diseases, Viral: Skin diseases caused by viruses.Skin Cream: A water-soluble medicinal preparation applied to the skin.Skin Physiological Processes: Biological activities and functions of the SKIN.Mice, Hairless: Mutant strains of mice that produce little or no hair.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Dermis: A layer of vascularized connective tissue underneath the EPIDERMIS. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are SWEAT GLANDS; HAIR FOLLICLES; and SEBACEOUS GLANDS.Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Skin Diseases, Parasitic: Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Keratosis: Any horny growth such as a wart or callus.Wound Healing: Restoration of integrity to traumatized tissue.Sunlight: Irradiation directly from the sun.Sunscreening Agents: Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Hair Follicle: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.Rats, Hairless: Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.9,10-Dimethyl-1,2-benzanthracene: 7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.Hair: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.Blister: Visible accumulations of fluid within or beneath the epidermis.Sunburn: An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight.Sebaceous Glands: Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.Skin Manifestations: Dermatologic disorders attendant upon non-dermatologic disease or injury.Langerhans Cells: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.Water Loss, Insensible: Loss of water by diffusion through the skin and by evaporation from the respiratory tract.Emollients: Oleagenous substances used topically to soothe, soften or protect skin or mucous membranes. They are used also as vehicles for other dermatologic agents.Dermatitis, Allergic Contact: A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Injections, Intradermal: The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Melanocytes: Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.Tuberculin Test: One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.Dermatitis, Occupational: A recurrent contact dermatitis caused by substances found in the work place.Dermatitis, Irritant: A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Surgical Flaps: Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.Intradermal Tests: Skin tests in which the sensitizer is injected.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Dermatomycoses: Superficial infections of the skin or its appendages by any of various fungi.Melanins: Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Pigmentation DisordersKeratosis, Actinic: White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Irritants: Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.Soft Tissue Infections: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)Mice, Inbred C57BLSkin Diseases, Papulosquamous: A group of dermatoses with distinct morphologic features. The primary lesion is most commonly a papule, usually erythematous, with a variable degree of scaling on the surface. Plaques form through the coalescing of primary lesions.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Body Temperature Regulation: The processes of heating and cooling that an organism uses to control its temperature.Forehead: The part of the face above the eyes.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Keratoacanthoma: A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Laser-Doppler Flowmetry: A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mice, Inbred SENCAR: Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Dermoscopy: A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Dermatitis, Exfoliative: The widespread involvement of the skin by a scaly, erythematous dermatitis occurring either as a secondary or reactive process to an underlying cutaneous disorder (e.g., atopic dermatitis, psoriasis, etc.), or as a primary or idiopathic disease. It is often associated with the loss of hair and nails, hyperkeratosis of the palms and soles, and pruritus. (From Dorland, 27th ed)Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Sweat Glands: Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.Exanthema: Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.Patch Tests: Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.Mice, Inbred BALB CHand DermatosesPermeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Sebum: The oily substance secreted by SEBACEOUS GLANDS. It is composed of KERATIN, fat, and cellular debris.Skin Lightening Preparations: Substances used to obtain a lighter skin complexion or to treat HYPERPIGMENTATION disorders.Ear, External: The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Hypersensitivity, Immediate: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.Anura: An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Self-Examination: The inspection of one's own body, usually for signs of disease (e.g., BREAST SELF-EXAMINATION, testicular self-examination).Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Ichthyosis: Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.PUVA Therapy: Photochemotherapy using PSORALENS as the photosensitizing agent and ultraviolet light type A (UVA).Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Needles: Sharp instruments used for puncturing or suturing.Clothing: Fabric or other material used to cover the body.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Iontophoresis: Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.Facial DermatosesTetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Keratolytic Agents: Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.Neoplasms, Adnexal and Skin Appendage: Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.Eczema: A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).Mechanoreceptors: Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.Hair Color: Color of hair or fur.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Ultraviolet Therapy: The use of ultraviolet electromagnetic radiation in the treatment of disease, usually of the skin. This is the part of the sun's spectrum that causes sunburn and tanning. Ultraviolet A, used in PUVA, is closer to visible light and less damaging than Ultraviolet B, which is ionizing.Anti-Infective Agents, Local: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.Nevus: A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Protective Clothing: Clothing designed to protect the individual against possible exposure to known hazards.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Nevus, Pigmented: A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.Alopecia: Absence of hair from areas where it is normally present.Carcinoma, Skin Appendage: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)Touch: Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.Epidermolysis Bullosa: Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.Soaps: Sodium or potassium salts of long chain fatty acids. These detergent substances are obtained by boiling natural oils or fats with caustic alkali. Sodium soaps are harder and are used as topical anti-infectives and vehicles in pills and liniments; potassium soaps are soft, used as vehicles for ointments and also as topical antimicrobials.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Pemphigus: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.Scleroderma, Diffuse: A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.Sunbathing: Exposing oneself to SUNLIGHT or ULTRAVIOLET RAYS.Dermatitis, Phototoxic: A nonimmunologic, chemically induced type of photosensitivity producing a sometimes vesiculating dermatitis. It results in hyperpigmentation and desquamation of the light-exposed areas of the skin.Physical Stimulation: Act of eliciting a response from a person or organism through physical contact.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Malassezia: A mitosporic fungal genus that causes a variety of skin disorders. Malassezia furfur (Pityrosporum orbiculare) causes TINEA VERSICOLOR.Keratosis, Seborrheic: Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.Dermatitis, Seborrheic: A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.Cocarcinogenesis: The combination of two or more different factors in the production of cancer.Thermography: Imaging the temperatures in a material, or in the body or an organ. Imaging is based on self-emanating infrared radiation (HEAT WAVES), or on changes in properties of the material or tissue that vary with temperature, such as ELASTICITY; MAGNETIC FIELD; or LUMINESCENCE.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Antisepsis: The destruction of germs causing disease.Amphibian Proteins: Proteins obtained from species in the class of AMPHIBIANS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Hair Diseases: Diseases affecting the orderly growth and persistence of hair.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Forearm: Part of the arm in humans and primates extending from the ELBOW to the WRIST.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Warts: Benign epidermal proliferations or tumors; some are viral in origin.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Scabies: A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.Clobetasol: A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Toes: Any one of five terminal digits of the vertebrate FOOT.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Pressure Ulcer: An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.Foot Dermatoses: Skin diseases of the foot, general or unspecified.Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Keratin-10: A type I keratin that is found associated with the KERATIN-1 in terminally differentiated epidermal cells such as those that form the stratum corneum. Mutations in the genes that encode keratin-10 have been associated with HYPERKERATOSIS, EPIDERMOLYTIC.Bandages: Material used for wrapping or binding any part of the body.Hand: The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.Feathers: Flat keratinous structures found on the skin surface of birds. Feathers are made partly of a hollow shaft fringed with barbs. They constitute the plumage.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Povidone-Iodine: An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)Croton Oil: Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.Eyelids: Each of the upper and lower folds of SKIN which cover the EYE when closed.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Granulation Tissue: A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.Gloves, Protective: Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Melanosis: Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.

Glycopeptides from the surgace of human neuroblastoma cells. (1/19537)

Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking.  (+info)

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. (2/19537)

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV blisters are due to loss of keratinocyte cell-cell adhesion in the superficial and deep epidermis, respectively. PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodies bind Dsg3 or both Dsg3 and Dsg1. In this study, we test the hypothesis that coexpression of Dsg1 and Dsg3 in keratinocytes protects against pathology due to antibody-induced dysfunction of either one alone. Using passive transfer of pemphigus IgG to normal and DSG3(null) neonatal mice, we show that in the areas of epidermis and mucous membrane that coexpress Dsg1 and Dsg3, antibodies against either desmoglein alone do not cause spontaneous blisters, but antibodies against both do. In areas (such as superficial epidermis of normal mice) where Dsg1 without Dsg3 is expressed, anti-Dsg1 antibodies alone can cause blisters. Thus, the anti-desmoglein antibody profiles in pemphigus sera and the normal tissue distributions of Dsg1 and Dsg3 determine the sites of blister formation. These studies suggest that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and demonstrate that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.  (+info)

Activation of telomerase and its association with G1-phase of the cell cycle during UVB-induced skin tumorigenesis in SKH-1 hairless mouse. (3/19537)

Telomerase is a ribonucleoprotein enzyme that adds hexanucleotide repeats TTAGGG to the ends of chromosomes. Telomerase activation is known to play a crucial role in cell-immortalization and carcinogenesis. Telomerase is shown to have a correlation with cell cycle progression, which is controlled by the regulation of cyclins, cyclin dependent kinases (cdks) and cyclin dependent kinase inhibitors (cdkis). Abnormal expression of these regulatory molecules may cause alterations in cell cycle with uncontrolled cell growth, a universal feature of neoplasia. Skin cancer is the most prevalent form of cancer in humans and the solar UV radiation is its major cause. Here, we investigated modulation in telomerase activity and protein expression of cell cycle regulatory molecules during the development of UVB-induced tumors in SKH-1 hairless mice. The mice were exposed to 180 mjoules/cm2 UVB radiation, thrice weekly for 24 weeks. The animals were sacrificed at 4 week intervals and the studies were performed in epidermis. Telomerase activity was barely detectable in the epidermis of non-irradiated mouse. UVB exposure resulted in a progressive increase in telomerase activity starting from the 4th week of exposure. The increased telomerase activity either persisted or further increased with the increased exposure. In papillomas and carcinomas the enzyme activity was comparable and was 45-fold higher than in the epidermis of control mice. Western blot analysis showed an upregulation in the protein expression of cyclin D1 and cyclin E and their regulatory subunits cdk4 and cdk2 during the course of UVB exposure and in papillomas and carcinomas. The protein expression of cdk6 and ckis viz. p16/Ink4A, p21/Waf1 and p27/Kip1 did not show any significant change in UVB exposed skin, but significant upregulation was observed both in papillomas and carcinomas. The results suggest that telomerase activation may be involved in UVB-induced tumorigenesis in mouse skin and that increased telomerase activity may be associated with G1 phase of the cell cycle.  (+info)

Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution. (4/19537)

The influence of metallothionein (MT) on Zn transfer into non-gut tissues was investigated in MT-null (MT-/-) and normal (MT+/+) mice 4 h after oral gavage of aqueous 65ZnSO4solution at doses of 154, 385, 770 and 1540 nmol Zn per mouse. Zn transfer was not significantly different between MT+/+ and MT-/- mice and was directly proportional to the oral dose (slope = 0.127, r = 0.991; 0. 146, r = 0.994, respectively). Blood 65Zn and plasma Zn concentrations increased progressively in MT-/- mice at doses >154 nmol Zn, reaching levels of 2.4% of oral dose and 60 micromol/L, respectively, at the 1540 nmol Zn dose. The corresponding values for MT+/+ mice were approximately half, 1.0% and 29 micromol/L. Intergenotypic differences were found in tissue distribution of 65Zn within the body; MT-/- mice had higher 65Zn levels in muscle, skin, heart and brain, whereas MT+/+ mice retained progressively more Zn in the liver, in conjunction with a linear increase in hepatic MT up to the highest Zn dose. MT induction in the small intestine reached its maximum at an oral dose of 385 nmol Zn and did not differ at higher doses. Absorption of a 770 nmol 65Zn dose from a solid egg-white diet was only one fourth (MT+/+) and one eighth (MT-/-) of the Zn absorption from the same dose of 65Zn in aqueous solution. MT+/+ mice had greater (P < 0.05) Zn absorption from the egg-white diet than did MT-/- mice, indicating that gut MT confers an absorptive advantage, but only when Zn is incorporated into solid food.  (+info)

Accumulation of astaxanthin all-E, 9Z and 13Z geometrical isomers and 3 and 3' RS optical isomers in rainbow trout (Oncorhynchus mykiss) is selective. (5/19537)

Concentrations of all-E-, 9Z- and 13Z- geometrical and (3R,3'R), (3R, 3'S) and (3S,3'S) optical isomers of astaxanthin were determined in rainbow trout liver, gut tissues, kidney, skin and blood plasma to evaluate their body distribution. Two cold-pelleted diets containing predominantly all-E-astaxanthin (36.9 mg/kg astaxanthin, 97% all-E-, 0.4% 9Z-, 1.5% 13Z-astaxanthin, and 1.1% other isomers, respectively) or a mixture of all-E- and Z-astaxanthins (35.4 mg/kg astaxanthin, 64% all-E-, 18.7% 9Z-, 12.3% 13Z-astaxanthin, and 2.0% other isomers, respectively), were fed to duplicate groups of trout for 69 d. Individual E/Z isomers were identified by VIS- and 1H-NMR-spectrometry, and quantified by high-performance liquid chromatography. Significantly higher total carotenoid concentration was observed in plasma of trout fed diets with all-E-astaxanthin (P < 0.05). The relative E/Z-isomer concentrations of plasma, skin and kidney were not significantly different among groups, whereas all-E-astaxanthin was higher in intestinal tissues and 13Z-astaxanthin was lower in liver of trout fed all-E-astaxanthin (P < 0.05). The relative amount of hepatic 13Z-astaxanthin (39-49% of total astaxanthin) was higher than in all other samples (P < 0.05). Synthetic, optically inactive astaxanthin was used in all experiments, and the determined dietary ratio between the 3R,3'R:3R, 3'S (meso):3S,3'S optical isomers was 25.3:49.6:25.1. The distribution of R/S-astaxanthin isomers in feces, blood, liver and fillet was similar to that in the diets. The ratio between (3S,3'S)- and (3R,3'R)-astaxanthin in the skin and posterior kidney was ca. 2:1 and 3:1, respectively, regardless of dietary E/Z-astaxanthin composition. The results show that geometrical and optical isomers of astaxanthin are distributed selectively in different tissues of rainbow trout.  (+info)

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (6/19537)

OBJECTIVE: To determine whether interferon-alpha (IFNalpha) reduces the severity of skin involvement in early (<3 years) diffuse scleroderma. METHODS: In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. Outcomes assessed were the modified Rodnan skin score, as determined by a single observer at baseline, 6 months, and 12 months, as well as data on renal, cardiac, and lung function. Pre- and posttreatment skin biopsy samples were analyzed and blood was obtained for assessment of procollagen peptide levels. RESULTS: There were 11 withdrawals from the IFNalpha group and 3 from the placebo group due to either toxicity, lack of efficacy, or death. In the intent-to-treat analysis, there was a greater improvement in the skin score in the placebo group between 0 and 12 months (mean change IFNalpha -4.7 versus placebo -7.5; P = 0.36). There was also a greater deterioration in lung function in patients receiving active therapy, as assessed by either the forced vital capacity (mean change IFNalpha -8.2 versus placebo +1.3; P = 0.01) or the diffusing capacity for carbon monoxide (mean change IFNalpha -9.3 versus placebo +4.7; P = 0.002). Skin biopsy showed no significant decrease in collagen synthesis in the IFNalpha group, and no significant differences in the levels of procollagen peptides were seen between the 2 groups. CONCLUSION: This study suggests that IFNalpha is of no value in the treatment of scleroderma, and that it may in fact be deleterious.  (+info)

Hydrophobic interaction of human, mouse, and rabbit interferons with immobilized hydrocarbons. (7/19537)

Interferons of human, mouse, and rabbit origin bind to straight chain hydrocarbons immobilized on agarose. The hydrophobic nature of binding is established by the following observations: (a) a positive correlation between the length of hydrocarbon ligand and the strength of interaction; (b) a stronger interaction with hydrocarbon ligands terminated with apolar rather than polar head groups; (c) a lack of dependence of binding on ionic strength and pH of the solvent; (d) a reversal of binding by ethylene glycol, a hydrophobic solute; (e) an increasing eluting efficacy of tetraalkylammonium ions with the length of their alkyl substituents. The hydrophobic interactions of human interferon underlie the efficiency of two-step chromatographic procedures. For example, human embryo kidney interferon can be purified about 3,600-fold by sequential chromatography on (a) concanavalin A-agarose, (b) octyl-agarose. Another two-step procedure: (a) concanavalin A-agarose, (b) L-tryptophan-agarose, gives about 10,000-fold purification. The overall recovery of interferon in both cases in close to 90%.  (+info)

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. (8/19537)

Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and permeability factor that is potently angiogenic in vivo. We report here studies that suggest that VEGF potentiates angiogenesis in vivo and prolongs the survival of human dermal microvascular endothelial cells (HDMECs) in vitro by inducing expression of the anti-apoptotic protein Bcl-2. Growth-factor-enriched and serum-deficient cultures of HDMECs grown on collagen type I gels with VEGF exhibited a 4-fold and a 1.6-fold reduction, respectively, in the proportion of apoptotic cells. Enhanced HDMEC survival was associated with a dose-dependent increase in Bcl-2 expression and a decrease in the expression of the processed forms of the cysteine protease caspase-3. Cultures of HDMECs transduced with and overexpressing Bcl-2 and deprived of growth factors showed enhanced protection from apoptosis and exhibited a twofold increase in cell number and a fourfold increase in the number of capillary-like sprouts. HDMECs overexpressing Bcl-2 when incorporated into polylactic acid sponges and implanted into SCID mice exhibited a sustained fivefold increase in the number of microvessels and a fourfold decrease in the number of apoptotic cells when examined 7 and 14 days later. These results suggest that the angiogenic activity attributed to VEGF may be due in part to its ability to enhance endothelial cell survival by inducing expression of Bcl-2.  (+info)

The individual, together with its environment, has been reported as the main force driving composition and structure of skin microbiota in healthy dogs. Therefore, one of the major concerns when analyzing canine skin microbiota is the likely influence of the environment. Despite the dense fur covering, certain skin diseases exhibit differential prevalence among skin sites, dog breeds, and individuals. We have characterized the normal variability of dog skin microbiota in a well-controlled cohort of a large number of Golden-Labrador Retriever crossed dogs (N = 35) with similar ages, related genetic background, and a shared environment. We found that the individual drives the skin microbiota composition and structure followed by the skin site. The main bacterial classes inhabiting dog skin in this cohort are Gammaproteobacteria and Bacilli. We also detected bacteria associated to the environment on different dog skin sites that could be reflecting the different degrees of exposure of each skin site and
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Background: Chronic pain is a common occurrence for burn patients and has significant impact on quality of life. However, the etiology is not well understood. Understanding the mechanisms underlying the restoration of sensory function and the development of chronic pain after burn is critical to improving long-term outcomes. Objective: To determine whether cutaneous innervation in burn patients with chronic pain is altered when compared to patients without chronic pain. Methods: Twelve patients with unilateral injury and who reported chronic pain were recruited. Each patient underwent sensory function testing and both scar and matched site uninjured skin biopsy. Biopsies were analyzed for total nerve density and nociceptive C-fiber density using immunohistochemistry. Results were compared to a control group of 33 patients with unilateral injury and no reported long-term pain. Results: Sensory function was significantly diminished in scar compared to uninjured tissue in both study groups, but ...
A novel in vitro culture system of organotypic human skin explants interfacing with external fixator pins is presented. The system was used to observe changes in skin morphology on the skin at the pin
Synonyms for fish scale disease, fish skin disease in Free Thesaurus. Antonyms for fish scale disease, fish skin disease. 35 synonyms for fish: angle, net, cast, trawl, look (for), search, delve, ferret, rummage, fossick, seek, look for, angle for, try to get, hope for, hunt for. What are synonyms for fish scale disease, fish skin disease?
TY - JOUR. T1 - MicroRNA expression analysis of human skin fibroblasts treated with high-fluence light-emitting diode-red light. AU - Mamalis, Andrew. AU - Koo, Eugene. AU - Tepper, Clifford G. AU - Jagdeo, Jared. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation in components of the transforming growth factor beta (TGF-B)/SMAD pathway. In contrast to ultraviolet phototherapy, high-fluence light-emitting diode-generated red light (HF-LED-RL, 633 ± 15 nm) is a safe, economic and non-invasive therapy with in vitro evidence that supports modulation of the key cellular characteristics involved in the pathogenesis of skin fibrosis. Limited data exists pertaining to the effects of HF-LED-RL on human skin fibroblast microRNA (miRNA). Herein, we explored the effects of HF-LED-RL on fibroblast miRNA levels using RNA-seq and miRNA ...
Synonyms for intracutaneous injection at with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
I was just diagnosed with this bug on my skin specimen, Toenails fell off and my bumps on legs still present. Nails - Answered by a verified Health Professional
branch and an active vasodilator branch [11]. Nonthermoregulatory reflexes, which include skin blood flow responses to changes in arterial and central venous pressure and exercise stresses, also operate through the two aforementioned branches of the sympathetic nervous system; however, the glabrous/ palmar skin operates only through the vasoconstrictor branch [10,11,41]. In the auto-regulation process, throughout a specific range of arterial blood pressure, steady-state blood flow is maintained at a fairly constant level [44]. Previous reports on cutaneous circulation has shown that, independent of neural control of blood flow, glabrous/palmar skin has the ability to buffer blood pressure oscillations and demonstrates a degree of dynamic auto-regulation. Conversely, nonglabrous or hairy skin has a diminished dynamic auto regulatory capacity [42]. We first tried to relate observations in the present study to some of the physiological findings reported earlier on the cutaneous responses to ...
Skin Section, 40 times full-size | Skin Models | The two halves of this skin relief model show the three layers of hairy and hairless skin in order to make clear the differences of the skin layers. This skin model features detail with hair follicles, sebaceous glands, sweat glands, receptor, nerves
Enthusiasm for diagnosis and therapy of skin disorders via skin microbiota has arisen from recent evidence that: (i) the dysbiosis of skin microbiota is not just associated with skin inflammations (39) but can be a driving factor (52), (ii) S. aureus colonization precedes the onset of AD in certain children (41, 44), (iii) commensal skin bacteria protect against pathogens (7), and (iv) recovery of skin health should require restoration of the healthy microbiota (15). However, these studies are mostly performed in a single localized and relatively homogenous cohort. However, in addition to body region and host individuality (53), the main factors affecting the skin microbiota include geographical location (54, 55). The lack of understanding of variation between healthy and diseased skin microbiota scales at different spatial dimensions, i.e., among geographically separated populations, has hindered critical assessment and exploitation of the potential of the skin microbiota as a quantitative, ...
ABSTRACT: Cleanser technology has come a long way from merely cleansing to providing mildness and moisturizing benefits as well. It is known that harsh surfactants in cleansers can cause damage to skin proteins and lipids, leading to after-wash tightness, dryness, barrier damage, irritation, and even itch. In order for cleansers to provide skin-care benefits, they first must minimize surfactant damage to skin proteins and lipids. Secondly, they must deposit and deliver beneficial agents such as occlusives, skin lipids, and humectants under wash conditions to improve skin hydration, as well as mechanical and visual properties. While all surfactants tend to interact to some degree with lipids, their interaction with proteins can vary significantly, depending upon the nature of their functional head group. In vitro, ex vivo, and in vivo studies have shown that surfactants that cause significant skin irritation interact strongly with skin proteins. Based on this understanding, several surfactants ...
Progress in tissue engineering has led to the development of technologies allowing the reconstruction of autologous tissues from the patients own cells. Thus, tissue-engineered epithelial substitutes produced from cultured skin epithelial cells undergo long-term regeneration after grafting, indicating that functional stem cells were preserved during culture and following grafting. However, these cultured epithelial sheets reconstruct only the upper layer of the skin and lack the mechanical properties associated to the connective tissue of the dermis. We have designed a reconstructed skin entirely made from human cutaneous cells comprising both the dermis and the epidermis, as well as a well-organized basement membrane by a method named the self-assembly approach. In this chapter, protocols to generate reconstructed skin and corneal epithelium suitable for grafting are described in details. The methods include extraction and culture of human skin keratinocytes, human skin fibroblasts as well as ...
The four pillars of Skin Delivery are a result of continuous conversation with the marketplace and our customers: Dermal drug delivery, Mildness, Sensory and Formulation Design. Learn more on why each pillar is crucial and plays an important role for Skin Delivery. ...
Skin tags are harmless growths on the skin that can vary in number. They are usually the same color as your skin or slightly darker. These tiny pieces of tissue are composed of blood vessels and a type of protein fiber called collagen. They project from the surrounding skin on a thin or thick stalk. While most skin tags are small, pinhead-sized bumps, they may become as large as a grape Skin tags can develop on any part of the body, but they most commonly grow on areas of high friction or areas that are commonly rubbed, such as, neck, breasts, groin, stomach, eyelids, underarms. Males and females are equally prone to getting skin tags. However, people may be more likely to develop skin tags if they are obese, are pregnant, or have diabetes Causes--Researchers dont know exactly what causes skin tags to grow. It is believed that friction may lead to the development of skin tags. The growths commonly occur in areas where skin constantly rubs against clothing or other skin, such as near yo ...
An automatic apparatus for testing cutaneous responses of a patient is disclosed. The embodiments of the invention variously include components for: applying a nonambient temperature to the patients skin to test the patients response to thermal stimuli; pricking the patients skin to test the patients response to pain; indenting the patients skin to test the patients response to touch; vibrating the patients skin to test the patients response to vibration; and for making two spaced apart contacts with the patients skin to test the patients two point discrimination response. A general purpose computer and dedicated control circuits function to control the operation of the system and record the responses of the patient. The embodiments of the present invention are able to repeatedly reproduce each test so that the tests carried out are reproducible and accomplished in a minimum of time.
View Notes - Chapter 19 from BIO 119 at Moraine Valley Community College. Chapter 19 Microbial Diseases of the Skin and Wounds Structure of the Skin Functions of the skin Prevents excessive water
With her always-glowing skin and radiant smile, its hard to believe that actress Jennifer Aniston turned 50 earlier this year. So how does the actress keep her skin in tip-top condition while balancing a hectic schedule? Recently in an interview with the Los Angeles Times, the actress revealed that her healthy skin and radiant glow is a combination of various things including her lifestyle, skincare and good genes. "I inherited good skin from my dad," the actress admitted. Aniston also offered the following tips for keeping skin youthful and healthy.. Balance Your Biome The importance of the skins microbiome has been in the spotlight in recent months and it appears that Aniston is a proponent of caring for the microbiome. "The whole thing is fascinating to me," said Aniston. The actress likes to try and use products that contain probiotics which can help keep the skins microbiome in balance, and in turn, promote healthy and resilient skin. Find out why the skins microbiome is so important ...
Purpose: To investigate the effect of the tissue origin of stromal fibroblasts and epithelial cells on reconstructed corneas in vitro. Methods: Four types of constructs were produced by the self-assembly approach using the following combinations of human cells: corneal fibroblasts/corneal epithelial cells, corneal fibroblasts/skin epithelial cells, skin fibroblasts/corneal epithelial cells, skin fibroblasts/skin epithelial cells. Fibroblasts were cultured with ascorbic acid to produce stromal sheets on which epithelial cells were cultured. After 2 weeks at the air-liquid interface, the reconstructed tissues were photographed, absorption spectra were measured, and tissues were fixed for histologic analysis. Cytokine expression in corneal- or skin-fibroblast-conditioned media was determined with the use of protein array membranes. The effect of culturing reconstructed tissues with conditioned media, or media supplemented with a cytokine secreted mainly by corneal fibroblasts, was determined. ...
For as much time that people put into making their skin look good, the act of promoting skin health is completely overlooked. The skin is an essential organ to the body, and luckily the skin is naturally able to build new cells and repair itself. The introduction of chemicals to the skin can speed up the rate at which cells die, and this can weaken the skin. The skin is an important factor to the immune system, because it helps to keep harmful pathogens from entering the body. Weakened skin can allow pathogens into the body where they may cause internal damage. The skin also protects the body from the suns rays, and it helps to promote a healthy body temperature. Skin is also important to how the body interacts with its environment, and it helps to trigger reactions to pain and pressure changes.. The skin carries out important jobs, but many people actively damage their skin on a daily basis. Many of the cosmetic and beauty products that are used to make the skin look good or youthful actually ...
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Viruses, bacteria and fungi are some of the infectious agents that can cause a skin infection. Sometimes the skin rash is a result of a systemic infection, as may be seen with chickenpox and measles. At other times the rash may be localized to the skin as is more common with bacteria and fungi.. Bacterial infections often tend to be the more serious as it can spread and lead to even life-threatening conditions. These bacterial infections may affect only the superficial layers (impetigo) or extend to underlying tissue (cellulitis). Most of the time there is a break in the skin that allows the bacteria to infect the area.. Fungi tend to cause superficial skin infections and are usually do not progress to any serious complications. These infections are often referred to a ringworm because the specific fungi that are responsible tend to cause a ring-like rash. Sometimes yeasts may also be responsible for abdominal skin infections.. ...
In fact, used regularly, It assists to regenerate the skins younger looking properties. Applying aloevera is useful through winter and summertime. In winter, It assists to help remedy dryness and conserve the soft texture in the skin. In summer, it soothes your skin layer, especially after sun-exposure. It also moisturises your skin layer, without making your skin layer oily. aloevera can also be combined with face masks. Take one tablespoon besan, one teaspoon every one of orange peel powdered ingredients and curd the other table spoon aloevera gel. Blend together and apply for the skin, washing it off after a half-hour. Its an effective moisturiser and for that reason helps in dry out skin problems. It assists to moisturise your skin layer and seal off the losing of moisture. It softens your skin layer and helps to take out dead skin cellular material. It also soothes your skin layer in cases involving sun damage or sun burn. If used often, It assists for you to preserve the skins younger ...
Murads Acne Control Skin Perfecting Lotion helps blemish-prone skin stay clear, smooth and healthy by providing oil-free hydration.
In the last few decades, autoimmune diseases have become a major clinical burden. The reasons for this are manifold, including (i) increasing incidence; (ii) the lack of therapies that target the underlying cause of the specific disease in question and (iii) the high rate of adverse events due to prolonged, unspecific immunosuppression. The skin is one of the largest organs of the human body and several autoimmune diseases manifest at the skin. These include skin-specific autoimmune diseases and cutaneous manifestations of systemic autoimmune diseases. Furthermore, with the recent success of immune checkpoint therapy in cancer, immune-mediated adverse effects on the skin following immune checkpoint inhibitor blockade treatment are becoming an additional challenge. Diseases that have been clearly defined as autoimmune diseases of the skin include vitiligo, scleroderma, pemphigus and pemphigoid diseases. Interestingly, recent evidence also indicates that other chronic inflammatory skin diseases and
When you workout, you increase your bodys ability to deliver more nutrients to your cells, whichfeeds the skins fibroblast cells that create skin tightening collagen.. So, while youre sculpting a stronger core, you can also be tightening the skin on your stomach. Its a win-win!. Do you need surgery?. Almost never. You almost neverneedsurgery to remove loose skin, unless it is causing major health issues, like making it difficult for you to move, or causing constant chafing thats resulting in infections. However, you may want surgery to remove loose skin that just isnt bouncing back as much as youd like. It happens.. Your skin is like a rubber band: you can only stretch it so much and so far before it becomes permanently warped. While a womans skin will stretch considerably during a full-term pregnancy, her skin will almost always retreat to taut form after a year, max. However, if a woman has multiple pregnancies close together, especially later in her life, the skin on her stomach may ...
Shingles symptoms are seen when the virus named varicella- zoster reinvades or gets reactivated in the body of a person. It is the same virus that causes the disease of chickenpox. The symptoms of this disease vary in each person.. Let us have a look at some common and early shingles symptoms. Early symptoms of shingles. • Upset abdomen. • Fevers and chills. • Swelling of the lymph nodes. • Feeling of sickness. • Swelling of the tender lymph nodes. • Severe headaches. • Sensations of burning on the skin. • Excessive itchiness. • Pain in the affected skin areas. • Sensitivity of the skin towards light. Moving away from shingles, we take a look at the various types of skin cancer that can invade the human body. Skin cancers are extensively diverse. The type of skin cancer that affects a person depends on the type of skin cells of that person, from which the cancer arises. Each skin cancer appears distinctly on the superficial skin lining of the bearer.. Some of the types of ...
In human skin tissue model studies at PNNL, researchers showed that ionizing radiation such as that from a CT scan is sufficient to alter genes in two cell layers.
As our age goes up, the nature of our skin decays and it will wind up dull and dry. Your skins common hyaluronic corrosive, a normally hydrating substance that keeps skin delicate and smooth, lessens and collagen and different strands that reason versatility will crumble. Therefore, your skin winds up dry, harsh, dull and less flexible. Gradually almost negligible differences and wrinkles show up all over. Medicines with botox skin promoters lift skins hydration and improve the surface, versatility, laxity of your skin.. These skin sponsors contain hyaluronic corrosive that can give your skin a characteristic brilliance by improving skins hydration framework. They will make your skin brilliant, smooth and delicate. Likewise, these skin sponsors contain nutrients, minerals, and enemies of oxidants. They will feed your skin and make it sound. So your skin will turn out to be increasingly versatile and firmer. These supporters can likewise treat skin inflammation scarring.. How does Skin ...
A wonderful skin treatment, it gives you all those benefits and a lot more. It is equally effective on your hair and even your nails. Consider using argan oil for skin care if you have wrinkles, scars and other skin problems that you want to be taken care of. Results of this great oil can be so overwhelming even if you use just a few drops of it everyday.If your blessed with the perfect look then consider yourself very lucky. Many of us have to work at it more than others. Fortunately, there are many very inexpensive ingredients that will help everyone look good and have beautiful skin. If were going to use natural ingredients for our skin care regimen, then we should be totally aware of our skin type and thus not end up using the wrong natural skin care products. Here are some great tips for various skin types as well as recipes for face masks.Skin care tips for normal skin.If you happen to be one of the lucky ones who have normal skin then count your blessings. This group hardly has any skin ...
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A healthy diet is essential to the health of your body, but its also essential to the health of your skin. A variety of nutrients, including protein, antioxidants, vitamins and collagen can help improve the way your skin looks. Healthy skin is easily recognizable because its usually glowing. Here are some nutrients to consume for healthy, glowing skin.. Nutrition for Skin Health. Eat Protein. A diet low in protein, over the course of many months, can cause a loss in skin tone. Your skin may start to sag and wrinkle beyond what would be reasonable for chronological age. Proteins are essential for tissue repair and the construction of new tissue. Cells need protein to maintain their life, so the body uses protein to "replace" worn-out or dead skin cells. Including proteins in your diet from sources like chicken, meat, fish, soy or tofu will help you solve that concern. Meal replacement protein shakes are also great options for protein consumption.. Importance of Antioxidants and Vitamins While ...
The results of this study suggest that IL-10 promotes the development of a Th2 response to antigen and is essential for skin infiltration with eosinophils in a mouse model of allergic dermatitis.. IL-10 can be expressed by both keratinocytes and cells of hemopoietic origin that are present in the skin, including DCs, macrophages, mast cells, and lymphocytes (2, 37). Our investigation was prompted by the observation that IL-10 mRNA is rapidly expressed in mouse skin following mechanical injury by tape stripping (Figure 1). This result is consistent with previous findings in human skin subjected to tape stripping (29). Dermal infiltration with eosinophils is an important feature of AD and a hallmark of allergic skin inflammation induced by EC sensitization with OVA (30). Skin from IL-10-/- mice failed to exhibit eosinophil infiltration following EC sensitization with OVA (Figure 2a). This is not due to poor survival of eosinophils, since there was virtually no detectable staining for the ...
... - Mona Agrawal, Preeti Yadav, Vinay Lomash, A S B Bhaskar, P V Lakshmana Rao
MDM-2 is one of the target genes of the p53 tumor suppressor protein. Its best characterized function is found in the inhibition of p53s ability to modulate transcription. Deregulated expression of MDM-2 could thus at least partially substitute for p53 mutation in the process of tumorigenesis. We show here that MDM-2 is highly expressed in biopsies of normal human skin or in vitro reconstituted human skin. The protein is detected in the nucleus of keratinocytes throughout the different layers of the epidermis and in reconstituted skin as early as the two to three cell layer stage. The 90 kiloDalton (kD) protein is one of the major forms detected in Western blot experiments. MDM-2 is detected in skin reconstituted from keratinocytes in which p53 is inactivated by mutation or degradation by E6 protein, providing evidence that MDM-2 expression in the skin can occur in the absence of wild type p53. Moreover, we found no correlation between the p53 status and MDM-2 expression levels in a series of ...
AppliedStemCell eCommerce Platform Human Skin Cells (Dermal Fibroblasts) cDNA (DT1) [ASD-9041] - Catalog Number ASD-9041 Quantity 20 reactions Product Information Description Applied StemCells cDNA is synthesized from a highly pure and intact total
As with all our body organs, skin ages as programmed by genes. This is called internal aging. Dry skin, age spots, white hair, hair loss, thin nails and other skin changes come purely due to age. Skin also ages by external factors. Sun is the main external factor that ages the skin. The sun rays consist of many light spectrums. Ultra violet rays damage the skin most. Both UVA and UVB are responsible for skin damage. Aging due to sun is called photo aging.. Sun-Sun breaks down the collagen and elastin in the skin. The skin loses its elasticity and firmness and develops premature wrinkles. Photo aging depends on the skin color and the amount of sun exposure over the years. Dark colored individuals show less sun damage while fair skinned people show more sun damage for the same exposure. With rising age, the total sun exposure increases and its gives rise to not only age spots, but also more serious problems such as actinic keratoses and skin cancers. The only way to prevent sun damage is ...
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It is well known that lipids (fatty substances) can have a positive effect on skin. A new project at the FRAME laboratory will enable close investigation of how lipids are absorbed to create those effects. The project will involve building three-dimensional models from keratinocytes, fibroblasts, melanocytes and immune cells. They will be isolated directly from ethically obtained skin samples, donated to Nottinghams City Hospital biobank by patients undergoing mastectomies.. Results from animal-based models are questionable because mouse skin differs from human skin in significant ways, both in structure and function. Once the new model is complete it will be possible to compare results from the new structures with those obtained using the actual skin samples from which they were derived, in order to demonstrate their accuracy.. ...
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SMP is performed by inserting pigment through the epidermis and into the upper dermal layer of the skin. The epidermis naturally sheds and regenerates approximately every 27-28 days. Immediately after the procedure, the implanted pigment is seen in both the upper dermis and epidermis, which is why it looks so dark and crisp. Over the course of the 27-28 days, as your skin goes through its natural exfoliation process, the residual pigment that is in the epidermis sheds as well. When the cells regenerate, the layer of epidermis no longer has pigment in it, but sits on top of the upper dermal layer where your permanent pigment resides. This results in a slightly less sharp pigment dot, since there is now a layer of skin on top of the permanent pigment.. ...
natural antioxidants to counter free radical damage.. The major cause of skin aging symptoms to appear is the slowdown in the natural production of collagen and elastin in the body. These are the youth giving skin proteins that help to keep the skin firm, pliant, supple and elastic.. And as we age through our twenties and early thirties, the body gradually produces less of these vital structural proteins. This is what gives us wrinkles, saggy skin, fine lines, old age spots and dark uneven skin complexion. Our skin begins to lose around 1.5% of collagen every year from the time we enter the early thirties. And its clear that we do not have to lose 100% of our collagen for wrinkles and fine lines to show up.. The best skin care for men should consist of cutting edge natural ingredients like Cynergy TK. It is unique in its role as a skin rejuvenator as it enhances the natural production of collagen and elastin by the body itself. This helps the skin to repair and renew itself just like it did in ...
The experimental investigations used skin fibroblasts cultures at a density of 50,000 cells/100ml of media (5% fetal calf serum 3% antibiotics) exposed to UVB doses (0-5.6 J/cm2) with damage levels assessed by two cytotoxicity assays (Figure 1).. The MTS results in Figure 2 showed a dose response relationship between exposure and cellular mitochondrial dehydrogenase activity as measured by the MTS assay. A decrease in the mitochondrial activity was directly associated with increased UVB dose. The cell exposure to a dose of 2.1 J/cm2 of UVB reduced the mitochondrial activity by more than 50%, while at 5.6 J/cm2 of UVB we witnessed a reduction in activity by 80%.. The relationship between UVB exposure and cellular viability was further investigated using the NR assay. The damage caused by UVB was assessed by determining the reduction in NR dye uptake by the lysosomes because cells with damaged cellular membranes leak and cannot retain the dye [10]. The leakage results in reducing the NR dye uptake ...
It is a common misconception that sags, droops, lines, wrinkles and folds are the result of skin stretching. While this can be the case with sudden weight loss, the primary cause of skin laxity is diminishing stores of collagen in deep skin layers. As we age our bodies produce less of this strong protein fiber that supports surface skin, and environmental factors like sun exposure and pollution further deplete collagen.. However, the human body has the ability to accelerate production of collagen when necessary for healing. For example, when the surface of skin is injured, such as from trauma or surgery, a great many new collagen bundles form in that spot to mend the wound. The scar that they create is strong, thick, and firm. The same thing is happening in deeper dermal layers; you just dont see it.. Innovative skin tightening technologies put that information to use, to tighten skin from the inside out. They use various modalities such as infrared light or ultrasound energy to warm deep ...
Fish skin cells. Epifluorescence light micrograph of three keratocytes (fish epidermal cells). The nuclei, which contain the cells genetic information in the form of deoxyribonucleic acid (DNA), are blue. Microtubules are yellow and actin is purple. Microtubules and actin are protein filaments, they form the cell cytoskeleton, which gives the cell its shape and the capacity for directed movement. When scales are plucked and placed on a glass slide, individual cells become extremely motile due to a wound healing response. As they also have a simple structure, these cells are used as a model system to study cell locomotion, metastasis (spread) of cancer cells, and wound healing. - Stock Image G450/0095
Coloured scanning electron micrograph (SEM) of Photocomposite, E. coli on the surface of human skin. Escherichia coli is a Gram-negative, facultatively anaerobic, enteric, rod prokaryote. This bacterium is normally a part of the human and animal microbiota. Most E. coli strains are harmless, but some strains can cause serious problems such as: food poisoning, urinary tract infections, travellers diarrhoea and nosocomial infections. The E. coli 0157:H7 strain is fatal to humans if contracted when contaminated meat is cooked inadequately. Magnification: bacteria x800; skin x6 when shortest axis printed at 25 millimetres. - Stock Image F017/4236
Differential assessment of the skin condition or wound is essential to understanding its cause and development. First, assess the patients skin temperature, dryness, itching, bruising, and changes in texture of skin and nail composition. Also, assess the skin for color and uniform appearance, thickness, symmetry, and primary or secondary lesions. Document all the findings of the skin assessment. Note, too, any presence of a skin condition: erythema, itching, scratching, skin weeping, skin blistering, bruising, primary lesions, secondary lesions, and open wounds.. Use Tables 1 and 2 to assist you in your practice when differentiating between primary and secondary lesions.. ...
Question - Cut the extra skin over the corn area, spots seems to be completely black and dead. Help?. Ask a Doctor about diagnosis, treatment and medication for Wart, Ask a Dermatologist
UV Radiation from Tanning Beds is Directly Linked to Skin Cancer. New York, NY (May 3, 2012) - As teens around the nation prep for their most glamorous night of high school, The Skin Cancer Foundation encourages young women who are prom planning to steer clear of tanning salons and embrace their natural skin tones, as ultraviolet (UV radiation) from tanning beds can lead to skin cancer. But for girls who cant resist the tanned look, pampering skin with bronzers and sunless tanners is always an option. "While tanning may seem like an easy way to achieve glowing skin before prom, just one trip to the tanning salon can mean the difference between healthy skin and premature skin aging that can lead to skin cancer later on," said Deborah S. Sarnoff, MD, Senior Vice President of The Skin Cancer Foundation.. The risks of indoor tanning are real-those who make just four visits to a tanning salon per year can increase their risk for melanoma by 11 percent, and their risk for the two most common forms of ...
Many skin conditions that surface in time originate from the deeper skin layers and are difficult to diagnose with the human eye. The Observ exposes those conditions by using a patented skin fluorescence and polarized light illumination technology. Using this unique technology, you can instantly reveal skin conditions, create awareness and propose your client targeted treatment programs.. The Observ 520 The Observ 520 with iPad offers a full-face skin diagnosis. You can switch between five different skin analysis mode which help us visualize depth of skin conditions and measure your progress throughout your clinic journey.. ...
Procedures:. Skin Culture A test that is performed to identify the microorganism (bacteria, fungus, or virus) causing a skin infection and to determine the antibiotic or other treatment that will effectively treat the infection. Skin Biopsy A procedure in which a sample of skin tissue is removed, processed, and examined under a microscope. A skin biopsy is performed to diagnose a skin condition, a disease, such as cancer, and a bacterial or fungal skin. Phototherapy Ultraviolet light to treat a variety of skin conditions. Surgeries Removal of cancers, moles and other skin lesions if required Patch Testing A way to identify whether a substance that comes in contact with the skin is causing inflammation of the skin (contact dermatitis). ...
Dry skin on your nose can result from a variety of causes. The cosmetics and soaps you use can make skin dry, and the aging process can cause skin to...
Human skin is made up of several layers and sublayers. The two main layers are the epidermis and the dermis. These layers cover a third layer of tissue called the hypodermis, which consists of fibrous and adipose connective tissue (Figure 16.2).. The epidermis is the outermost layer of the skin, and it is relatively thin. The exterior surface of the epidermis, called the stratum corneum, primarily consists of dead skin cells. This layer of dead cells limits direct contact between the outside world and live cells. The stratum corneum is rich in keratin, a tough, fibrous protein that is also found in hair and nails. Keratin helps make the outer surface of the skin relatively tough and waterproof. It also helps to keep the surface of the skin dry, which reduces microbial growth. However, some microbes are still able to live on the surface of the skin, and some of these can be shed with dead skin cells in the process of desquamation, which is the shedding and peeling of skin that occurs as a normal ...
This periodical review is an effort to make readers aware of recent trends in skin research as revealed in mid-2006 publications. The subjects have been organized into the impact of light on normal human skin, photo-aging, and skin repair, with special emphasis on the drug-induced repair of photo-aged skin.
Vitamin A - Helps maintain and repair skin tissue, and helps prevent a dry complexion.. Vitamin B - Promotes healthy cells and prevents dry skin.. Vitamin C - Stimulates the production of collagen (an important protein for the skin) and improves skin texture by reducing skin damage and wrinkles.. Vitamin E - Helps the body ward off sun damage (age spots and wrinkles); protects against other elements that lead to skin damage such as pollution.. Beta-carotene - Stimulates skin cell growth, repairs skin damage and protects cell membranes.. Lutein - A naturally occurring carotenoid (organic pigment) that increases skin hydration and elasticity.. Lycopene - Rejuvenates cells and helps reduce the effects of UV light. (Still, always wear sunscreen even if youre eating a whole bunch of tomatoes!). Omega-3 Fatty Acids - Reduces inflammation.. Selenium - A mineral that helps in skin cancer prevention and protects against skin damage. Also, its the feel good mineral.. Sulforaphane - A cancer-fighting ...
9-day embryo 1 2 3 4 5 7 14 26 5 6 18 4 13 2 8 2 4 3 3 7 1 10-day embryo 1 4 7 14 a b 1 2 3 2 1 2 3 1 Feather-like structures. Slow-growing cultures. 6. Primary Dissociated Epidermis and Primary Dissociated Cultured Separately in Diffusion Chambers on the CAM Mesoderm Primary dissociated epidermis would not form a compact mass in the diffusion chamber but spread over the surface of the membrane filter which made u p the floor of the chamber. N o structures were observed to develop, and no keratin was detected in 7 cases. 8. Primary Dissociated Whole Skin Grown on Plasma Clot Feather-like elements arranged in a fabric of skin developed in pellets of dissociated whole skin cells placed in plasma clot (Fig. 14). These resemble the structures which arose in grafts of cells grown for 3 days in culture (Fig. 10). T h e y consisted of rings of keratinizing cells disposed around a lumen which was sometimes empty and sometimes filled with keratin. T h e large number of regularly spaced structures which ...
This back to school science lesson plan focuses on the two regions of the skin and the underlying layer. A discusion about injuries to the skin will reinforce what students learn about the layers of the skin and how they protect what is under the skin.
The Retseliney Face and Neck Firming Cream contains organic and natural ingredients that will nourish your skin and make it look younger and healthier. It is a skin tightening cream that will help to lift your skin and make it firmer. The hydrating ingredients will help to moisturize the areas around your neck, face, chin and décolletage, reducing the appearance of sagging skin. As it is a clinically proven formula, it will not cause any allergies or skin reactions and can be used safely.. In addition to its various natural ingredients, it also contains vitamin C that protects your skin against antioxidants and helps to keep your skin look younger for longer. It improves the elasticity and tone of your skin. The product contains glycolic acid, botanical hyaluronic acid and peptides that work not only on the outer layers of your skin but at the deeper levels as well. These also help to boost your skins natural collagen production and tighten up the skin. It also acts on fine lines, wrinkles and ...
Know Your Skin cases. First of all its crucial to know you re skin type so that you can choose skin care products to become you. Do you have normal skin, dry skin, dehydrated skin, oily skin, mature skin, or sensitive skin? . Dry or Very Dry Skin. P [...]. ...
For those looking to both prevent and reduce the visible signs of aging and maintain or restore a youthful glow, medical grade skin care is one of the easiest, cheapest, and most effective places to start. One key ingredient doctors and aestheticians across the country turn to for healthy, glowing skin is growth factors. What Are Growth Factors. Growth factors are naturally found all over our body, including in our skin. They are signal molecules, which tell our cells to divide, repair, and grow. In the skin, they are responsible for repairing everyday damage, such as that from sun exposure, and supporting proper skin cell turnover.. However, one of the most important roles that growth factors play in aging skin is stimulating the fibroblasts (key skin cells within the dermis) which house our collagen and elastin. Collagen plays a critical role in maintaining the health and appearance of the skin and is primarily responsible for keeping skin elastic and plump. Since collagen production declines ...
Your skin doesnt just cover you. It does a whole lot more. According to, skin functions as protective wrapping. Along with a layer of fat underneath, it insulates you against all kinds of bumps, bangs and wear and tear. It keeps germs and water OUT (unless you have a break in your skin) and keeps your bodys fluids and salts IN. Skin manufactures and oozes out all sorts of wonderful liquids. Waxes and oils act as your bodys natural waterproofer and a protector against germs. They make your skin softer; but they can also give you pimples. Your skin also contains glands which manufacture sweat. With sweat, not only does your body get cooled by its evaporation, but it has a convenient way to get rid of chemicals it doesnt need. Skin is alive. Its made of many thin sheets of layers of flat, stacked cells in which youll find nerves, blood vessels, hair follicles, glands, and sensory receptors. Older cells are constantly being pushed to the surface by new cells which grow from ...
Smoking makes your skin look older and contributes to wrinkles. Smoking narrows the tiny blood vessels in the outermost layers of skin, which decreases blood flow. This depletes the skin of oxygen and nutrients that are important to skin health.. Smoking also damages collagen and elastin - the fibers that give your skin strength and elasticity. In addition, the repetitive facial expressions you make when smoking - such as pursing your lips when inhaling and squinting your eyes to keep out smoke - can contribute to wrinkles.. If you smoke, the best way to protect your skin is to quit. Ask your doctor for tips or treatments to help you stop smoking.. Daily cleansing and shaving can take a toll on your skin. To keep it gentle:. ...
Your image along with your self esteem both are reliant on it. Therefore, this post will talk about a few helpful suggestions to assist you to get your skin layer in shape.. Dont shave dried-out skin. Make an effort to also avoid shaving if you dont use a product like shaving cream to work with. Dry shaving irritates your skin and can lead to razor burn. After shaving, apply lotion in your skin. This can help soothe any irritation and moisturizes your skin.. In order to treat bad skin, fresh lemon juice may help you. By using a fresh lemon juice application every few days will also help to tone the skin.. Make certain your moisturizers are unscented and hypoallergenic to protect yourself from any harmful ingredients. Dry skin could be caused by the alcohol contained in some products. Browse the ingredients on any lotions you acquire. When you see that this contains alcohol or a fragrance, try another thing.. Make use of a makeup sponge to apply your sunscreen. Besides applying sunscreen with a ...
Standfords School of Medicine brings us an update in the latest achievements towards in-vitro neuron generation via re differentiation of specialized cells (skin cells in this case.) This important progress follows on last years success in inducing this change with mice skin cells. The importanc...
Ageing is a natural process and everyone has to go through this process. Ageing brings many changes in the body especially skin. Signs of ageing are clearly visible on the skin if one does not take proper care of skin. One has to take extra care of the skin to prevent early signs of ageing. It is a regular process and one has to pay attention to the skin on a regular basis. Different signs of ageing include wrinkles, fine lines, dark spots and discoloration. These changes occur due to loss of elasticity and lesser production of collagen and elastin. We should take different measures to maintain the natural integrity of our skin by eating right food and using right anti ageing skin care products. You can also try below given skin care tips to rejuvenate your skin ...
Applicable people: eye skin aging relaxation the appearance of fine lines and other flaws.Because everyones skin characteristic each different all the adaptability to different skin care products are also different.Before using any kind of new skin care products it is recommended that you ear skin after the trial if you are unwell feeling or abnormal skin reactions suggested that stop using or consult your doctor immediately ...
Learn how to get healthy skin with tips from Clearasil®. Find out how to maintain healthy skin by eating healthy, keeping hydrated and more.
Has excellent moisture properties, nourishes the cells with moisture and smoothed the skin from within, as well as antibacterial and wound-healing effect. Restores brightness of colors, maintains skin elasticity, promotes skin lifting. Foam effectively cleanses the skin, keeps the lipid barrier of the skin, promotes hydration and nutrition. It has a mild sedative effect. Snail mucin protects cells from damage and premature aging; restores and improves skin, evens skin tone, rejuvenates and tightens the skin. Ginseng has a rejuvenating effect on the skin, it moisturizes the skin, normalizing the water-salt balance.
This Presentation: Overview of Dermal and Subdermal Lesions Define the Lesion Types: Benign Nodular Lesions Papules and Plaques Pigmented Lesions Subepidermal Lesions Benign Dermatoses Malignant Lesions Surgical Treatment and Biopsy Surveillance and Follow-up
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Small portions of skin that appear to be attached to or protrude from normal skin and are benign condition of the skin. Usually just a few milliliters in diameter, skin tags vary in appearance. Some are the same color as surrounding skin while others are hyperpigmented. In most cases, they are attached to the underlying skin by a small band of tissue called stalk or peduncle. Skin tags can occur almost anywhere there is skin. Areas for tags are the eyelids, neck, armpits, upper chest (particularly under the female breasts), and groin folds. Tags are typically thought to occur in characteristic locations where skin rubs against the skin or clothing.. ...
The natural collagen is the principal structural skin protein. Bundles of collagen molecules pack together throughout the dermis, accounting for three-fourths of the dry weight of skin. Collagen is also responsible for the skins strength. Collagen is produced by cells called fibroblasts, which are found scattered throughout the dermis. Skin has a considerable stock of…
The skin is the largest organ of the human body, comprising approximately 17% of the body weight. An average adult would have a skin total surface area of around 1.7 square meters. The thickness of the skin varies depending on the site where it resides, ranging from 3mm to 6mm. The skin is the most visible and exposed organ of the body, and hence it is the first line of defense of the body against the harsh environment.. The structure of the skin comprises of three main layers, namely the epidermis, the dermis and the hypodermis. There are also skin appendages that play their own respective roles in the skin. Each make-up of each layer will be described below.. EPIDERMIS. The epidermis is the most dynamic layer among all the layers of the skin. Despite being the thinnest layer, it is actually the most important layer among all. The epidermis consists of 5 sub-layers, that will be listed below:. (a) Stratum germinativum (basal cell layer) - This is the deepest layer composed of keratinocytes. ...
The Skin The main layers of the skin are:The main layers of the skin are: The epidermis The epidermis The dermis The dermis The epidermis is the cellular layer and lacks blood vessels or lymphatics. It can be divided, from bottom to surface, into the:The epidermis is the cellular layer and lacks blood vessels or lymphatics. It can be divided, from bottom to surface, into the: The basal layerThe basal layer Stratum spinosumStratum spinosum Stratum ganulosumStratum ganulosum Stratum corneumStratum corneum
Skin can take quite a beating during the average lifetime. Its the bodys first defense against the outside world, so its no surprise that it pays a hefty price at the hands of age. Among factors such as smoking, UV exposure and the natural breakdown of proteins, the skin will begin to lose its natural elasticity over time. But why?. The first thing to know about the bodys largest organ is that the skin is composed of two specific layers: the epidermis and the dermis. While the epidermis protects your body against environmental hazards, the dermis is made up of the proteins and collagens responsible for skins elasticity. And while it is still unknown how these two layers interact over time or why exactly the skin is unable to "bounce back" from certain damages, scientists have several theories as to why the skin faces irreparable damage with age.. Medical News Today explores three major reasons why skin loses its youthful appearance.. First, the dermis is made up of extracellular matrix ...
As skin cells get closer and closer to the outer surface of the body they lose their blood supply and die. This is an effective strategy of the body to eliminate wastes in these cells by sloughing off these old dead cells. Every minute we lose over 30,000 dead skin cells which are replaced by new healthy skin cells. Bathing and good personal hygiene practices enhance the normal eliminatory patterns of the skin.. Dry skin brushing helps to improve circulation, stimulates lymphatic drainage and firms the skin. The improvement in circulation improves brain function and gives an individual more energy. By improving lymphatic flow, it can help prevent the formation of unsightly cellulite. Dry brushing also sloughs off old dead skin cells and the toxic debris within them while initiating the development of new healthy skin cells. ...
Our skin is the largest organ of the human body. Clearly, it is not just a simple group of tissues covering your entire body; our skin is much more than that.
You should know what you are using on your skin. If you cant pronounce the majority of the ingredients or there are more than 5 or 6 ingredients, then it may be too complex for what your skin actually needs. Skin care that uses these types of formulations are full of fillers, coloring, preservatives, and chemicals that are not beneficial for your skin and come with a high price where the consumer is paying for the filler more so than the active ingredients. These types of ingredients are only needed to fill up the bottle and make it appealing to smell or touch. Sometimes products will contain multiple active ingredients but in order to formulate these ingredients, it requires that other ingredients be added. You end up paying for something your skin cannot use. The cheaper ingredients are filling up the bottle. Try a similar approach to how you would choose your food (skin is live cells and needs nourishment). Watch the labels and choose products with skin healthy formulations where the ...
If you have a normal skin type, youre lucky. Not only do you benefit from barely having breakouts, you dont suffer with skin irritation and your pores arent visible. You can use any type of product, from light lotions to heavier, richer moisturisers; your skin will absorb these and remain soft, glowing, and firm on a daily basis. The main focus in your skincare routine should be to maintain healthy skin through regular cleansing, hydration, and protection. Below is a range of products that have been handpicked to match your skin type.. ...
Buy Diabetic Skin Care Supplies on Sale. Get low prices on diabetes supplies including Diabetes Lotions, Healing Creams, Gels and more at Allegro Medical.
Skin Culture Peel is an advanced and safe skin peeling treatment. Skin Culture Peel improves the skin appearance. When this treatment is applied on the skin it helps in improving uneven skin tone.
Epidermis maintenance systems that are created of organic materials are more practical because you are getting back your entire worth. If you are to spend your money in these items, you will preserve more. Why? First, these organic healthy skin maintenance systems are created to take of your childs skin so you are paying it for what its expected to do. Second, these healthy skin maintenance systems are not severe to the skin; they do not cause to further illnesses. This helps you to preserve in the sense that you wont have to buy other items youll need to treat whatever damage is triggered on your childs skin. Also, it removes the opportunities of hospitalizations due to skin issues ...
What is the best treatment for translucent skin - Layer of white translucent skin on? More Information. Its hard to know without more information. Is this something youve always had? Or is it new? Does it itch? Is it everywhere? Or only in certain places. You could be experiencing dry skin which may appear as you described above. Also if youve been sunburned recently and are shedding skin which appears white and translucent. Try using gentle moisturizers to keep skin healthy.
Your skin is exposed to environmental elements every day. Over the years, the sun s rays, pollution, and other damaging agents can take a toll on your skin. Micro-dermabrasion treatment can help reduce or eliminate wrinkles, fine lines, sun spots, acne scars, in-grown hairs, brown spots, blemished skin, dull skin, thickened skin and undesired pigmentation that may appear on the skin over time.
I have just started a PhD and have been trying to extract total RNA from skin samples from mice for RT-PCR analysis of cytokines. I know that other people have managed to do this type of analysis before as there is published data. My RT-PCR step is fine as my positive controls are working beautifully but the message from the skin samples is at best very weak. So if any one has any suggestions re: more efficient extraction methods (currently using Guanidium, CsCl gradient and phenol method) or any other helpful tips for this work I would be very grateful if they could get in touch. Thanks, Ginny Shires University of York ...
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Dry skin is a common issue on babies and even newborns. Find out the reasons for babys dry skin and what kinds of products can help to treat it.
There is a higher prevalence of patients who meet the criteria for an alcohol use disorder who also suffer from inflammatory skin dermatoses.
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Question - Bruised skin on the hand due to injury. Taken TT injection 4 years back . Is it still effective?. Ask a Doctor about diagnosis, treatment and medication for Tetanus, Ask an Orthopaedic Surgeon
Study Shows Tanning Booths Cause Skin Cancer: A new 2012 study has revealed that over 170,000 cases of skin cancer strike indoor tanners each year. The tanning bed cancer is called non-melanoma and is the most common type of skin cancer that affects Americans.
Fat rolls and flabby skin on the abdomen can cause a decline in confidence levels, especially when you have a swimsuit-bearing occasion coming up. To make matters worse, research has shown that people who carry their extra weight around their waist have the highest risk of all of heart attacks, strokes and other problems that arise from clogged, hardened arteries according to the University of Michigan. Lose the rolls, improve your health and flatten your belly by making the right lifestyle adjustments ...
Long wave UVA radiation (340-400 nm) causes detrimental as well as beneficial effects on human skin. Studies of human skin fibroblasts irradiated with UVA demonstrate increased expression of both anti-fibrotic heme oxygenase-1 (HO-1) and matrix metalloproteinase 1 (MMP-1). The use of UVA -induced MMP-1 is well studied in treating skin ...
Aging not only affects the skin of the face, but also the hands. Hands may start showing signs of aging before face does. The skin on the back of the hand is much thinner than the face, and contains much less fat. As the skins natural collagen and elastin fibers begin to break down, hands begin to show signs of aging. Textures can change and veins might begin to get bigger. Wrinkles and thin and translucent skin are also signs of aging hands. Tips to prevent aging of the hands: 1) Use suitable photo protective products according to the season of the year and the type of skin. 2) Use moi ...
have a few questions.. 1) Do expired BDH polyLlysine slides have an effect on IHC staining besides the fact that they dun stick tissues on as well? 2) Does 4% paraformaldehyde as a fixative need to be prepared freshly before each use? It should be fine if its stored at 4C up to two months ? 3) Have been doing pgp 9.5 IHC on skin specimens (Hypothenar 3mm punches) for a while and sometimes looking for the fibres in the epidermis can be difficult. Sometimes its positive and sometimes its not. Staining protocol is , fixation in 4 % paraform. overnight followed by sucrose o/n and cut in a cryostat at 30um . Sections stained o/n 4C followed by use of DAKO envision kit . Anything wrong with this protocol? Pls help. Greatly appreciated. --------------------------------- Do you Yahoo!? New and Improved Yahoo! Mail - 1GB free storage! _______________________________________________ Histonet mailing list [email protected] ...
This article explains whether smoking cause skin cancer or not and also explains symptoms, prevention and treatments of skin cancer.
Neutrogena Healthy Skin® Anti-Aging Eye Cream for wrinkles and fine lines is proven to give you smoother skin around the eyes. Neutrogena
Since snail mucus claims to repair the skin and vanish acne scars, ofcourse at first I was excited to try out this one. But then later, it somehow disappoints me. This snail mucus sleeping pack is not really centered towards skin repair, but it is for restoring the skins elasticity and giving a healthy skin. My skin does feel healthy throughout the use. Did not see much changes on the elasticity side, maybe it will work better on a mature skin. What I like about this sleeping pack is that it has a light gel consistency and it really penetrates into the skin even after applying it twice (I do this because I want to finish the product early and find a replacement). The gel dries matte. It is moisturizing enough for people with oily skin like me but I think the moisture provided is not enough for dry to normal skin types, you guys definitely need more moisture for the night and throughout the night. This is not a bad product overall, it just does not give the result that I wanted ...
While being a potent eliminator in the body, the skin can be clogged with wastes and dead skin leading to toxicity. By dry skin brushing before showering, you will promote the lymph (immune) system to release toxins and wastes assisting in drainage, tightening the skin and toning muscles. The skin forms a new layer every day, so skin brushing removes old, dead layers leading to softer, smoother, healthier glowing skin and more efficient detoxification. ...
Looking for online definition of sleeps in a whole skin in the Medical Dictionary? sleeps in a whole skin explanation free. What is sleeps in a whole skin? Meaning of sleeps in a whole skin medical term. What does sleeps in a whole skin mean?
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TY - JOUR. T1 - Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. AU - Keyse, Stephen M.. AU - Tyrrell, Rex M.. PY - 1987/10/25. Y1 - 1987/10/25. N2 - We have analyzed the pattern of protein synthesis in solar near ultraviolet (334 nm, 365 nm) and near visible (405 nm) irradiated normal human skin fibroblasts. Two hours after irradiation we find that one major stress protein of approximately 32 kDa is induced in irradiated cells. This protein is not induced by ultraviolet radiation at wavelengths shorter than 334 nm and is not inducible by heat shock treatment of these cells. Although sodium arsenite, diamide, and menadione all induced a 32-kDa protein, they also induced the major heat shock proteins. In contrast, the oxidizing agent, hydrogen peroxide, induced the low molecular weight stress protein without causing induction of the major heat shock proteins. A comparison of the 32-kDa proteins induced by ...
Radiation-induced skin injury is a common complication of radiotherapy. The RHIZOMA COPTIDIS and COPTIS CHINENSIS aqueous extract (RCE) can ameliorate radiation-induced skin injury in our clinical observation. But, the protective mechanism of RHIZOMA COPTIDIS and COPTIS CHINENSIS in radiation-induced skin injury remains unclear. In this experiment, we developed a radiation-induced skin injury rat model to study the mechanism. The animals were randomly divided into control group, treatment group, radiation group, and treatment and radiation group. 5 rats in each group were separately executed on 2 d and 49 d post-radiation. The semi-quantitative skin injury score was used to measure skin reactions by unblinded observers, and hematoxylin and eosin staining was used to evaluate the damage areas by irradiation. The MDA content, SOD activity of skin and serum were measured to detect the oxidative stress. Acute skin reactions were caused by a single dose of 45 Gy of β-ray irradiation, and the skin injury
Treatment of Ordinary dry skin usually isnt serious, but it can be uncomfortable and unsightly, turning plump cells into shriveled ones and creating fine lines and wrinkles. More serious dry skin conditions, such as the inherited group of disorders called ichthyosis, can sometimes be disfiguring enough to cause psychological distress, Fortunately, most dry skin results from environmental factors that can be wholly or partially controlled. These include exposure to hot or cold weather with low humidity levels, long-term use of air conditioning or central heating, and excessive bathing, Chronic or severe dry skin problems may require a dermatologists evaluation. But first you can do a lot on your own to improve your skin, including using moisturizers, bathing less and avoiding harsh, drying soaps, Dry Skin, Dry Skin Causes, Dry Skin Treatment, Dry Skin Symptoms, Dry Skin Definition, Dry Itchy Skin, Dry Skin Therapy, Chronic Dry Skin, Cures For Dry Skin, Dry Skin And Acne, Dry Skin Cures, Dry Skin
Looking for Epidermolytic hyperkeratosis? Find out information about Epidermolytic hyperkeratosis. Hypertrophy of the cornea. Hypertrophy of the horny layer of the skin. excessive development of the corneous layer of the skin in humans. Hyperkeratosis may... Explanation of Epidermolytic hyperkeratosis
Magnolol, a plant lignan isolated from the bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on chemically-induced skin cancer development. The objectives of this investigation are to study the anticarcinogenic effects of magnolol on UVB-induced skin tumor development in SKH-1 mice, a model relevant to humans, and determine the possible role of apoptosis and cell cycle arrest involved in the skin tumor development. UVB-induced skin carcinogenesis model in SKH-1 mice was used for determining the preventive effects of magnolol on skin cancer development. Western blottings and flow cytometric analysis were used to study the effects of magnolol on apoptosis and cell cycle. Magnolol pretreated groups (30, 60 μ g) before UVB treatments (30 mJ/cm2, 5 days/week) resulted in 27-55% reduction in tumor multiplicity as compared to control group in SKH-1 mice. Magnolol pretreatment increased the cleavage of caspase-8 and poly-(-ADP-ribose) polymerase (PARP), increased the
Lichen sclerosus is also known as lichen sclerosis or lichen sclerosus et atrophicus. It is a painful skin condition that typically affects the genitals and anus.
Skins[edit]. Audacious has full support for Winamp 2 skins, and as of version 1.2, some free-form skinning is possible. Winamp ... Audacious 1.x allows the user to adjust the RGB color balance of any skin, effectively making a basic white skin equivalent to ... The program can use Windows Bitmap (.bmp) graphics from the Winamp archive, although native skins for Linux are usually ... wsz skin files, a type of Zip archive, can be used directly, or can be unarchived to individual directories. ...
Skin[edit]. The most common side effects are mucocutaneous: dry lips, skin and nose. Other common mucocutaneous side effects ... The dose may need to be decreased to reduce the severity of these side effects.[33] The skin becomes more fragile-especially to ... It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to ... Wachter K (2009). "Isotretinoin's Mechanism of Action Explored". Skin & Allergy News. 40 (11): 32. doi:10.1016/S0037-6337(09) ...
Skin[edit]. Thick, elastic and closely fitting. No flabs apart from a slight dewlap along the lower (ventral) part of the neck ...
Bacterial skin infection may occur due to skin break down from scratching.[5][11] Systemic poisoning may occur if the bites are ... Skin[edit]. Individual responses to bites vary, ranging from no visible effect (in about 20-70%),[5][3] to small macular spots ... The signs left by the bites are the same as in case of people and cause identical symptoms (skin irritation, scratching etc).[ ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 446. ISBN 978-0-7216-2921-6.. .mw-parser- ...
"Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care". Pediatric Dermatology. ... Skin care[edit]. Olive oil has a long history of being use as a home skincare remedy. Egyptians used it alongside beeswax as a ... Besides food, olive oil has been used for religious rituals, medicines, as a fuel in oil lamps, soap-making, and skin care ... Applying olive oil to the skin does not help prevent or reduce stretch marks.[53] ...
Their skins were exposed to harmful ultraviolet rays that had previously been absorbed by the water. The skin changed to become ... Their skin contains little keratin and lacks scales, apart from a few fish-like scales in certain caecilians. The skin contains ... 1968). "Investigations on the skin toxin of the adult rough-skinned newt, Taricha granulosa". Copeia. 1968 (2): 307-313. doi: ... Amphibian skin is permeable to water. Gas exchange can take place through the skin (cutaneous respiration) and this allows ...
Skin injuries[edit]. Cyanoacrylate adhesives may adhere to body parts, and injuries may occur when parts of the skin are torn ... Cyanoacrylate may also be a skin irritant, causing an allergic skin reaction. The American Conference of Governmental ... In the US, due to its potential to irritate the skin, the U.S. Food and Drug Administration (FDA) did not approve its use as a ... "Topical skin adhesives. DermNet NZ". Retrieved 2016-06-29.. ...
Skin depigmentation[edit]. Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. It does ... "Clear N Smooth Skin Toning Cream recalled". Retrieved 4 April 2018.. *^ a b United States Food and Drug Administration (2006). ... a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ... While using hydroquinone as a lightening agent can be effective with proper use, it can also cause skin sensitivity. Using a ...
Skin[edit]. For a small number of people, taking aspirin can result in symptoms resembling an allergic reaction, including ... Aspirin and other NSAIDs, such as ibuprofen, may delay the healing of skin wounds.[104] Aspirin may however help heal venous ... Aspirin can induce swelling of skin tissues in some people. In one study, angioedema appeared one to six hours after ingesting ... or acute skin irritation.[25] As with other NSAIDs, combinations of aspirin and caffeine provide slightly greater pain relief ...
"In the dark: what is behind India's obsession with skin whitening?".. *^ "Skin whitening big business in Asia". Public Radio ... where British officials consistently demeaned dark-skinned Indians and favored light-skinned Indians for jobs over dark-skinned ... Skin-lightening creams are popular in Pakistan, especially among women.[19] Many ads feature light-skin models in good light ... This precise and repeatable test of skin color revealed that white women experience skin color discrimination in education at ...
Skin diseases[edit]. The skin and the lens have the same embryological origin and so can be affected by similar diseases.[18] ...
Expression in skin tissue[edit]. Both HSP70 and HSP47 were shown to be expressed in dermis and epidermis following laser ...
For skin. The latest threat to endangered Asia elephants is high and increasing demand for elephant skin.[61] The skin is used ... Skin colour is usually grey, and may be masked by soil because of dusting and wallowing. Their wrinkled skin is movable and ... Gosling, Justin (April 2018). Skinned; The growing appetite for Asian elephants (PDF). London: Elephant Family. p. 1. Retrieved ... Skin temperature varies from 24 to 32.9 °C (75.2 to 91.2 °F). Body temperature averages 35.9 °C (96.6 °F).[4] ...
Skin. As many as 70% of people with lupus have some skin symptoms. The three main categories of lesions are chronic cutaneous ( ... Micrograph of a section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a ... Direct immunofluorescence can detect deposits of immunoglobulins and complement proteins in the people's skin. When skin not ... Diseases of the skin including the Exanthemata (Vol. 1 ed.). London, England: The New Sydenham Society. pp. 114-116.. ...
Skin[edit]. Rash, including rare cases of erythema multiforme and rare cases of hair loss and vasculitis have been seen.[15] ...
13.4 Medicines affecting skin differentiation and proliferation. *13.5 Scabicides and pediculicides. *14 Diagnostic agents * ...
Diseases of the skin include skin infections and skin neoplasms (including skin cancer).[28] ... The two main types of human skin are glabrous skin, the nonhairy skin on the palms and soles (also referred to as the " ... Layer of skin involved[edit]. Main article: Integumentary system. The skin weighs an average of 4 kg (8.8 lb), covers an area ... Main article: Epidermis (skin). The epidermis is the most superficial layer of skin, a squamous epithelium with several strata ...
Skin[edit]. Cats possess rather loose skin; this allows them to turn and confront a predator or another cat in a fight, even ... The particularly loose skin at the back of the neck is known as the scruff, and is the area by which a mother cat grips her ... The fold of skin forming a pouch on the lower posterior part of the ear, known as Henry's pocket, is usually prominent in a ... Cat's skin has the same color as the fur but the color of the nose leather is probably dictated by a dedicated gene. Cats with ...
... flour and skins[edit]. Almond flour or ground almond meal combined with sugar or honey as marzipan is often used as a ... Almonds contain polyphenols in their skins consisting of flavonols, flavan-3-ols, hydroxybenzoic acids and flavanones[51] ... Liu Z, Lin X, Huang G, Zhang W, Rao P, Ni L (2014). "Prebiotic effects of almonds and almond skins on intestinal microbiota in ... These phenolic compounds and almond skin prebiotic dietary fiber have commercial interest as food additives or dietary ...
Skin friction. Main article: Parasitic drag. Skin friction arises from the interaction between the fluid and the skin of the ... Skin friction is caused by viscous drag in the boundary layer around the object. There are two ways to decrease skin friction: ... Skin friction is a component of drag, the force resisting the motion of a fluid across the surface of a body. ... Skin friction follows the drag equation and rises with the square of the velocity. ...
... and increased wrinkling of the skin and a reduction in skin elasticity, firmness, and strength.[23][24] These skin changes ... Skin health[edit]. The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including in ... These benefits include increased skin collagen content, skin thickness and elasticity, and skin hydration and surface lipids.[ ... decreased ground substance between skin fibers, and reduced capillaries and blood flow.[23][24] The skin also becomes more dry ...
Skin avulsions[edit]. The most common avulsion injury, skin avulsions usually occur during motor vehicle collisions. The ... In rock climbing, a "flapper" is an injury in which parts of the skin are torn off, resulting in a loose flap of skin on the ... Skin grafting. References[edit]. *^ "Avulsion". The Free Dictionary. Retrieved 14 March 2013.. .mw-parser-output cite.citation{ ... Jeng, S.F., & Wei, F.C. (1997, May). Classification and reconstructive options in foot plantar skin avulsion injuries. Plastic ...
"Melanoma Skin Cancer". American Cancer Society. American Cancer Society. Retrieved 5 July 2017.. ...
... is a long-term skin condition characterized by patches of the skin losing their pigment.[1] The patches of skin ... Skin with vitiligo, when exposed to a blacklight, will glow blue. In contrast, healthy skin will have no reaction.[citation ... If the affected person is pale-skinned, the patches can be made less visible by avoiding tanning of unaffected skin.[22] ... When skin lesions occur, they are most prominent on the face, hands and wrists.[6][7] The loss of skin pigmentation is ...
For the skin[edit]. emollients, anti-pruritics, antifungals, disinfectants, scabicides, pediculicides, tar products, vitamin A ...
... flour and skins[edit]. Almond flour or ground almond meal combined with sugar or honey as marzipan is often used as a ... Almonds contain polyphenols in their skins consisting of flavonols, flavan-3-ols, hydroxybenzoic acids and flavanones[41] ... The oil is good for application to the skin as an emollient, and has been traditionally used by massage therapists to lubricate ... Liu Z, Lin X, Huang G, Zhang W, Rao P, Ni L (2014). "Prebiotic effects of almonds and almond skins on intestinal microbiota in ...
That is because the skin needs to be grown from parts of the patients healthy sin. "Creating this new type of skin using stem ... will aid the immediate use of artificially-grown skin for major burn patients, since the skin could be stored in tissue banks ... One of the problems major-burn victims currently have is that, in order to apply the current techniques of artificial skin, a ... One of the problems major burn victims have is that, using the current protocols for artificial skin, they need to wait various ...
Artificial Skin: The skin generated in vitro is in fact the epidermis portion of skin only; when the epidermis is applied to ... the burnt part, this leads to the regeneration of dermis (remaining parts of skin) beneath. But improvements in the appro ... Artificial skin from newborn skin explants is used to wrap the wound until the patients skin is cultured and artificial skin ... Skin cells of new-borns grow more strongly than adult skin; the use of a synthetic polymer called as PGA helps the newborn skin ...
Source: New Hydrogel Hybrid Could Be Used To Make Artificial Skin. Share this:. *Click to share on Twitter (Opens in new window ... New Hydrogel Hybrid Could Be Used To Make Artificial Skin. July 16, 2016 in Technology ... which could be used to make artificial skin and longer-lasting contact lenses. ...
... more than 13 million workers in the United States are potentially exposed to chemicals that can be absorbed through the skin. ... The skin is the bodys largest organ, accounting for more than 10 percent of body mass. The skin provides a number of functions ... Skin Notation (SK) Profiles. NIOSH has developed a strategy for assigning multiple skin notations (SK) capable of delineating ... Dermal absorption is the transport of a chemical from the outer surface of the skin both into the skin and into the body. ...
Sleep deprived women show signs of premature skin aging and a decrease in their skins ability to recover after sun exposure," ... "This research shows for the first time, that poor sleep quality can accelerate signs of skin aging and weaken the skins ... Researchers evaluated the womens skin and conducted a variety of skin challenge tests including ones involving UV light ... Now heres another good reason to get enough sleep: sleep deprivation also could cause your skin to age faster, according to a ...
Inner skin *Do dogs sweat? *Skin diseases *Skin parasites *Immune deficiencies *Skin, skin, glorious skin Introduction. Skin is ... Skin, skin, glorious skin. Healthy skin is a reflection of the general health of the dog. A bright, shiny coat, smooth skin, ... Canine skin. Skin: Protection from the whimsies and weapons of the environment. *Introduction * ... In short, skin is a wonderful invention.. Skin comes in three layers: epidermis, dermis, and panniculus. The epidermis is the ...
Learn about the kinds of skin cancer and the 3 types of UV light. ... Skin Cancer * Basic Informationplus icon *What Is Skin Cancer? ... Skin cancer is the most common form of cancer in the United States. The two most common types of skin cancer-basal cell and ... UVB rays, which help produce vitamin D in the skin, dont reach as far into the skin as UVA rays, but they can still cause ... In addition to causing sunburn, too much exposure to UV rays can change skin texture, cause the skin to age prematurely, and ...
Learn about skin conditions, including causes, symptoms, and treatment. ... Your skin is your bodys largest organ. It covers and protects your body. ... Skin Biopsy (National Library of Medicine) Also in Spanish * Skin Cancer Screening (National Library of Medicine) Also in ... Skin lesion removal (Medical Encyclopedia) Also in Spanish * Skin lesion removal-aftercare (Medical Encyclopedia) Also in ...
The adjective cutaneous means "of the skin" (from Latin cutis, skin). In mammals, the skin is an organ of the integumentary ... The density of skin flora depends on region of the skin. The disinfected skin surface gets recolonized from bacteria residing ... For skin in humans, see human skin. For other uses, see Skin (disambiguation). ... Skin of a different nature exists in amphibians, reptiles, and birds.[1] All mammals have some hair on their skin, even marine ...
Larger defects may require repair with a skin graft, local skin flap, pedicled skin flap, or a microvascular free flap. Skin ... Skin grafting is patching of a defect with skin that is removed from another site in the body. The skin graft is sutured to the ... Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... These include changes in the skin that do not heal, ulcering in the skin, discolored skin, and changes in existing moles, such ...
The skin is tested to look for skin conditions or diseases. A skin biopsy can help your health care provider diagnose ... A skin lesion biopsy is when a small amount of skin is removed so it can be examined. ... Skin biopsy; Shave biopsy - skin; Punch biopsy - skin; Excisional biopsy - skin; Incisional biopsy - skin; Skin cancer - biopsy ... A skin lesion biopsy is when a small amount of skin is removed so it can be examined. The skin is tested to look for skin ...
Just my skin but Its really bothering and affects me a lot because my skin starts stinging when im taking a test or what not ... He told me that from what he could tell from my story and from seeing me, was that I had some sort of dry skin condition. He ... i occationally get stinging pains that shoot through my skin on my stomach, usually on the left side of my belly button.they ... The stinging pain is caused by clogged pours on the skin. If you dont sweat regularly you will keep getting it. ...
... , Getting the Facts and Preventing It Lauren Dansereau MS ANP Health Educator Western New England College ... It is the skins response and defense to UV rays exposure. Skin responds by producing melanin, a pigment that darkens the skin ... 5. Skin Cancer Types They are named for the skin cell types that become cancerous Squamous and Basal Cell are the most common ... Skin Cancer * 1. Skin Cancer, Getting the Facts and Preventing It Lauren Dansereau MS ANP Health Educator Western New England ...
... Quick! Whats the bodys biggest organ?. You might be surprised to find out its the skin, which you might not think ... Skin Can Warm and Cool You. Your skin can help if youre feeling too hot or too cold. Your blood vessels, hair, and sweat ... Without skin, peoples muscles, bones, and organs would be hanging out all over the place. Skin holds everything together. It ... Unlike other organs (like your lungs, heart, and brain), your skin likes a good washing. When you wash your skin, use water and ...
... sensitive skin is commonly, and somewhat vaguely, used to describe a number of transient and unpleasant sensations. What ... Table 2. Main neurological differential diagnoses for sensitive skin.. Factor. Sensitive skin. Small-fiber neuropathies. ... Table 1. Differences between rosacea flushes and sensitive skin.. Factor. Sensitive skin. Rosacea. ... Wounds, skin fragility. None. None. Associated subjective symptoms. None. Sensory deficit. Sensory deficit. Sensory deficit. ...
Australias luxury natural skin brand that uniquely features handmade fresh plant extracts. Simplicite products n... ... Love your skin mid-50s - use nutritive skin care! - Duration: 111 seconds.. *330 views ... Take years off your skin with all natural plant based ingredients - Duration: 90 seconds.. *160 views ... Why top quality ingredients are essential in natural skin care - Duration: 72 seconds.. *201 views ...
The skinscope allows you to see the health of your skin on a deeper level. It shows level of hydration, pigmentation, and ... Nichols uses The Skin Scope to show what lies beneath. - Duration: 1:13. NicholsMD of Greenwich Dermatology 1,664 views ... Introducing the Skin Scanner - Massage Envy Spa Edina - Duration: 2:00. Massage Envy Edina 2,803 views ... Skin Analysis Procedure - - Duration: 3:11. Bizzibox Films 27,787 views ...
Using a skin care range designed for oily skin types when your skin is not classified as oily can dehydrate the skin further ... Avoid mixing skin care products.  Use professional skin care products designed for your skin. (See our Womens and Mens skin ... dehydrated skin causing skin sensitivity  Extreme climates  Harsh and/or incorrect skin care products used on the skin.  Hot ... The use of good skin care products suited to your skin type.  Be gentle with your skin  Avoid using granular facial scrubs ( ...
3M makes products that make a real impact in your everyday life. Our products have made driving at night easier, buildings safer materials lighter, faster and better for a better planet.
Prevent dry skin. Scratching dry or itchy skin can open it up and allow infection to set in. Moisturize your skin to prevent ... Good skin care. There are several things you can do to prevent skin problems:. *Keep your diabetes well managed. People with ... Keep skin clean and dry. *Avoid very hot baths and showers. If your skin is dry, dont use bubble baths. Moisturizing soaps may ... Skin Complications. Diabetes can affect every part of the body, including the skin. In fact, such problems are sometimes the ...
... smoother skin? Laser skin rejuvenation offers real results and the ability to wipe away sun damage, discoloration, wrinkles and ... Laser Skin Rejuvenation Are you looking for younger, smoother skin? Laser skin rejuvenation offers real results and the ability ... laser skin resurfacing offers the best and most dramatic results for overall skin rejuvenation. Learn more about laser skin ... Trust your skin and health to an OHSU provider. Knowing what laser is the most appropriate to use can only occur when your ...
Hair and nails are actually modified types of skin. ... Our skin protects the network of tissues, muscles, bones, ... Skin Cells and Layers. The upper layer of our skin, the epidermis, is the tough, protective outer layer. It is about as thick ... Our skin can also respond to situations and emotions: Muscles in the skin called erector pili contract to make the hairs on our ... Your skin is your largest organ. If the skin of a typical 150-pound (68-kilogram) adult male were stretched out flat, it would ...
Rare lymphomas that start in the skin are called skin lymphomas (or cutaneous lymphomas). ... Lymphoma of the Skin Causes, Risk Factors, and Prevention. Learn about the risk factors for lymphoma of the skin and what you ... Lymphoma of the Skin Early Detection, Diagnosis, and Staging. Know the signs and symptoms of lymphoma of the skin. Find out how ... Treating Lymphoma of the Skin. If you are facing lymphoma of the skin, we can help you learn about the treatment options and ...
Description Skin lesions can be grouped into two categories: primary and secondary. ... Skin Lesions Definition A skin lesion is a superficial growth or patch of the skin that does not resemble the area surrounding ... A specialized skin cell that produces melanin, a dark pigment (color) found in skin.. Rash: A spotted pink or red skin ... Skin Lesions. Definition. A skin lesion is a superficial growth or patch of the skin that does not resemble the area ...
Has spread to very small areas of nearby skin (satellite tumors) or to skin lymphatic channels around the tumor (without ... Has spread to very small areas of nearby skin (satellite tumors) or to skin lymphatic channels around the tumor (without ... Has spread to very small areas of nearby skin (satellite tumors) or to skin lymphatic channels around the tumor (without ... Has spread to very small areas of nearby skin (satellite tumors) or to skin lymphatic channels around the tumor (without ...
  • That is because the skin needs to be grown from parts of the patient's healthy sin. (
  • One of the problems major burn victims have is that, using the current protocols for artificial skin, they need to wait various weeks in order for it to be grown, using healthy skin from the own patient. (
  • Spanish scientists, from the Tissue Engineering Research Group, from the Dept. of Histology at the University of Granada, have managed, for the first time, to grow artificial skin from stem cells of umbilical cord. (
  • To grow the artificial skin, the researchers have used, in addition this new type of epithelia covering, a biomaterial made of fibrin and agarose, already designed and developed by the University of Granada research team. (
  • One of the problems major-burn victims currently have is that, in order to apply the current techniques of artificial skin, a number of weeks are needed. (
  • Creating this new type of skin using stem cells, which can be stored in tissue banks, means that it can be used instantly when injuries are caused, and which would bring the application of artificial skin forward many weeks", as explained by Antonio Campos, Professor of Histology at the University of Granada and one of the authors of this study. (
  • MIT engineers have developed a method to bind gelatin-like polymer materials called hydrogels and elastomers, which could be used to make artificial skin and longer-lasting contact lenses. (
  • Here you can find out all about skin lymphomas, including risk factors, symptoms, how they are found, and how they are treated. (
  • Some signs and symptoms of overuse include thinning of skin, increased appetite and weight gain, acne, and deposits of fat around the chest, face, back, and stomach. (
  • The visible manifestations of sunburn usually begin within 6-12 hours after the first ultraviolet exposure and peak within 24-28 hours, followed by a gradual easing of symptoms and light tanning or "peeling" (the sloughing off of the skin ), depending on the severity of the burn . (
  • Skin manifestations is a term that describes the cutaneous signs, symptoms or physiological changes of a non-dermatological disorder. (
  • The free app helps you to take consistent photos of affected areas to track the effectiveness of your treatment, so you can get a clearer view of your skin and symptoms as they change. (
  • A person with a positive skin test, a normal chest X-ray, and no symptoms most likely has only a few TB germs in an inactive state and is not contagious . (
  • Any three or more of these symptoms are associated with the Morgellons skin parasite plus a co infection of protozoan and or Lyme disease. (
  • It is not at all uncommon for a child with asthma to have the asthma settle, but to have the skin symptoms persist (or vice versa). (
  • UVA rays can reach deep into human skin and damage connective tissue and the skin's DNA. (
  • Skin is the soft outer tissue covering vertebrates . (
  • In mammals , the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue , and guards the underlying muscles , bones , ligaments and internal organs . (
  • Severely damaged skin may heal by forming scar tissue . (
  • Loss of muscle tone resulting in sagging skin tissue. (
  • Skin grafts will not survive on tissue with a limited blood supply (cartilage or tendons) or tissue that has been damaged by radiation treatment. (
  • they are oval capsules of sensory nerve fibers located in the subcutaneous fatty tissue sebaceous gland - a small, sack-shaped gland that releases oily (fatty) liquids onto the hair follicle (the oil lubricated and softens the skin). (
  • In January, 1998, this multilayered, tissue-engineered skin trade marked Apligraf received unconditional recommendation from the FDA advisorypanel for treating venous leg ulcers, making it the first living manufactured organ ever recommended for approval by the FDA. (
  • Necrotizing fasciitis-a serious but uncommon infection that can spread rapidly and destroy skin, fat, muscle tissue and fascia, the layer of tissue covering muscle groups. (
  • One modification is the addition of a three-dimensional 'elevator' that builds on damaged tissue with fresh layers of healthy skin. (
  • Non-healing wounds, such as diabetic ulcers, venous ulcers, or pressure sores, can be treated with skin grafts to prevent infection and further progression of the wounded area. (
  • Many skin problems, such as acne , also affect your appearance. (
  • We continue to invite yourconcerns regarding your skin and its nuances, and we continue to passionately develop tailored natural skin caretreatments for our many clients.Acne/Acneic SkinCharacteristics:  Blackheads  Whiteheads  Papules  Pustules  CystsThe grade and severity of acne will depend on the quantity of the above-mentioned lesions present at any giventime. (
  • This can lead to acne when pores become clogged by too much sebum and too many dead skin cells. (
  • The Imagine App is tailor-made for people living with skin conditions such as psoriasis, eczema, rosacea or acne to help you stay on top of your condition. (
  • If you stay up late night after night to edit your vows or redo your seating chart, you'll not only miss out on this natural glow-getting process, you'll likely have a surge in stress hormones that can lead to unwanted skin concerns like acne. (
  • When cortisol is elevated, "it can aggravate skin conditions such as acne, rosacea and eczema. (
  • An electric face brush is great for acne prone skin. (
  • If your skin is prone to problems such as acne or rosacea, it can be particularly important to find a beauty regimen that treats your skin without causing flare ups or irritation. (
  • And to get skin ready from one season to another, the spa offers the Detoxifying Facial, a 60-minute therapeutic facial aimed at clarifying, nourishing and healing congested skin and acne conditions. (
  • I hope at the very least that all of his active acne will be healed, and that his skin will be at least a bit more moisturized and protected from future breakouts," she says. (
  • Sensitizers may not cause immediate skin reactions, but repeated exposure can result in allergic reactions. (
  • Studies show that absorption of chemicals through the skin can occur without being noticed by the worker, and in some cases, may represent the most significant exposure pathway. (
  • Sleep deprived women show signs of premature skin aging and a decrease in their skin's ability to recover after sun exposure," Baron said in a press release. (
  • Researchers evaluated the women's skin and conducted a variety of skin challenge tests including ones involving UV light exposure. (
  • The signs of aging catch up with everyone eventually, but limiting sun exposure can reduce the extent of damage to skin. (
  • Skin aging is caused by a combination of natural aging and exposure to sunlight. (
  • Actinic keratoses , also known as solar keratoses, are dry, scaly patches of skin caused by damage from years of sun exposure. (
  • This UV radiation exposure leads to damage to the DNA of the cells of the skin. (
  • There are significant risks for skin lesions resulting trauma to the skin while administering care, from exposure to pressure during immobilization, or from reaction to medications used in treatment. (
  • UVC rays are considered the most dangerous and can damage unprotected skin with only brief exposure. (
  • Thus, for those interested in these types of products, considering the reasons for seeking out skin lightening and speaking with a dermatologist (skin specialist) can help determine what options may be most appropriate and pose the lowest health risks. (
  • Cosmetic dermatologist Anna Guanche , who stocks snail products at her office at the Bella Skin Institute, tells me that snail mucin seals in moisture and allows active ingredients to penetrate the skin very well. (
  • New York City-based dermatologist Dr. Debra Jaliman, author of Skin Rules , shared her top tips for achieving flawless summer skin, and how to deal with a burn, should it happen. (
  • A dermatologist treats the skin. (
  • I went to SCA because the traditional approach of a dermatologist just wasn't going to cut it with my brother's skin and his special needs," Callie, who resides in the San Francisco area, tells Yahoo Lifestyle . (
  • Skin that is damaged extensively by burns or non-healing wounds can compromise the health and well-being of the patient. (
  • And when people age or develop diabetes, their skin loses resilience, leaving them prone to hard-to-heal wounds that can turn gangrenous, necessitating amputation. (
  • But in the not too distant future, scientists hope that artificial skin technology may advance to the point where it can replace the real thing, and we'll be able to quickly and seamlessly patch burns and wounds without harvesting skin from other sites on our hides, and produce grafts that are even more functional. (
  • Teaming up during the 1970s, the two found thatcollagen fibers and a long sugar molecule (called a polymer) could be combined to form a porous material that resembled skin and, when placed on wounds of lab animals, seemed to encourage the growth of new skin cells around it. (
  • Wounds are breaks in the integrity of the skin and tissues. (
  • Yet in the case of large or deep wounds, like Tomas', the skin doesn't heal because it has become so infected, it turns gangrenous and can't grow new cells. (
  • Liquid plastic skin bandage is a new product that seals wounds. (
  • This research shows for the first time, that poor sleep quality can accelerate signs of skin aging and weaken the skin's ability to repair itself at night," said Dr. Daniel Yarosh, a senior vice president at The Estée Lauder Companies, in a press release. (
  • Keratin is also found in skin cells in the skin's outer layer, where it helps create a protective barrier. (
  • Dead skin cells are polished away with the help of Alumina (Aluminum Oxide), the same key ingredient used by dermatologists to dramatically improve skin's texture. (
  • Want a smooth, soft, tighten and more radiant skin? (
  • And, just out, the Algae Brightening Mask promises to reduce fine lines, improve texture, and absorb excess sebum and impurities for a smoother and more radiant skin. (
  • Artificial skins are only used when sufficient quantities of such skin grafts aren't available, such as when someone sustains massive burns over more than half his or her body. (
  • Up to half of the grafts of these skins don't take, for example. (
  • In a study of 85 burn patients, Dermagraft, used as a temporary skin until permanent skin grafts could be done, cutthe need for surgery in half and reduced hospital stays my months. (
  • Pharmaceutical and biotech companies are extracting collagen -- a protein that makes up 75 percent of skin -- from donated skin and creating grafts, or patches, that can induce a patient's own skin to grow. (
  • Seems like whenever i would sweat from activity or nervousness it would dissolve whatever i was allergic to into the sweat and subsequently onto my skin. (
  • Allergic skin reactions can occur in response to medicines, such as insulin or diabetes pills. (
  • In this section you'll find information about the different medicines available to treat skin allergies, such as allergic eczema or reactions to insect bites and stings . (
  • An allergic skin reaction to an insect bite or sting can be treated with an antihistamine medicine taken by mouth. (
  • The itch of an allergic skin reaction such as an insect bite can be relieved with the following creams. (
  • Allergic eczema is best treated with a short course of a steroid cream to reduce the inflammation in the skin. (
  • Skin care specialists, also called aestheticians, provide skin care treatments to clients to help them look and feel great. (
  • This faster-than-average growth is attributed to the popularity of skin care treatments for relaxation and wellness. (
  • In honor of National Healthy Skin Month, o2 Living, Northern Westchester's premier natural health and wellness community offering a Live Food Café, therapeutic spa, juice cleanses, all natural skin treatments and products, yoga, and meditation classes, is helping clients to naturally prepare their skin for winter by eating for natural beauty. (
  • However, some treatments may help restore skin color and skin bleaching may be used to help the entire body become one lighter color. (
  • One of the most popular skin treatments is derma rolling. (
  • Eye treatments that contain vitamin K and advanced peptides can help to strengthen and brighten the skin. (
  • Some eye treatments contain light diffusing pigments that help the skin appear more radiant. (
  • Don't forget this is only a guide - talk to your doctor or pharmacist if you've any questions about treatments for skin allergies. (
  • Typically, an artist who's reached his zenith uses the best and priciest beauty treatments and consults experts who help him maintain his luminous skin. (
  • Our skin also controls the loss of life-sustaining fluids like blood and water, helps us regulate body temperature through perspiration, and protects us from the sun's damaging ultraviolet rays. (
  • This covering is necessary because the skin protects the body from fluid loss, aids in temperature regulation , and helps prevent disease-causing bacteria or viruses from entering the body. (
  • Main roles: makes new skin cells, gives skin its color, protects the body. (
  • The sweat comes up through pores , tiny holes in the skin that allow it to escape. (
  • These glands, which surround and empty into our hair follicles and pores, produce an oil called sebum (pronounced: SEE - bum) that lubricates the skin and hair. (
  • This exfoliating scrub is suitable for sensitive skin and leaves pores feeling deeply cleaned. (
  • Dead and dull skin is removed with exfoliants such as fruit seeds that can help to unclog pores. (
  • They can be of tremendous benefit for various skin ailments, and allow the skin to breathe, by not clogging the pores with any unnatural buildup. (
  • An electric face brush does most of the work for you by spinning to deeply clean and unclog your pores while thoroughly massaging your cleanser into your skin. (
  • Sweat and sebum reach the surface of the skin through tiny openings called pores. (
  • These cells keep the skin layer moist. (
  • UV rays can penetrate and damage skin cells. (
  • As newer cells continue to move up, older cells near the top die and rise to the surface of your skin. (
  • What you see on your hands (and everywhere else on your body) are really dead skin cells. (
  • Though you can't see it happening, every minute of the day we lose about 30,000 to 40,000 dead skin cells off the surface of our skin. (
  • These keep your skin cells healthy by bringing them the oxygen and nutrients they need and by taking away waste. (
  • Without the nerve cells in our skin, we couldn't feel warmth, cold, or other sensations. (
  • A dry, horny build-up of dead skin cells that often flakes off the surface of the skin. (
  • Consisting of a fabric of human or other mammalian cells combined with synthetic or biocompatible materials, these fake skins are placed on a wound to provide a protective barrier against infection and prevent leakage of vital fluids. (
  • These can prevent the colonization of other pathogenic microbes by using up the nutritional sources that those harmful microbes require to survive and by producing toxic substances that stop the pathogens from adhering to skin cells. (
  • It starts in skin pigment cells called melanocytes. (
  • We shed around 500 million skin cells each day. (
  • New research, just published in the journal Cell Reports, suggests that sperm cells can be created in the lab from skin cells. (
  • Their 84 minerals play a critical role in skin cells communicating with one another at a biologic level, and being able to regenerate and nourish the top layer of the skin with an improved water capacity. (
  • PEDICURE DEAD SKIN REMOVER HEAD - The dead skin remover will efficiently removes the head cells and dead skins at your elbow or under your foot. (
  • Meanwhile, at nearby Harvard University, Howard Green had begun culturing human skin cells under sterile conditions and growing a sheet of human epidermiscells from a tiny piece of a person's skin. (
  • This research has produced a product called Graftskin --a living skin equivalent made of purified bovine collagen into which dermal cells from infant boys' foreskin have been "seeded. (
  • On top of that layer is an epidermal layer ofthe cultured human skin cells. (
  • The immune system produces antibodies against specific proteins in the skin and mucus membranes, and the antibodies break the bonds between skin cells. (
  • Vitamin A is an anti-inflammatory and supports the health of our skin cells. (
  • It happens when the pigment cells are destroyed, leaving patches of lighter skin in various places on the body. (
  • Once the new cells have been applied, they mature and form new skin. (
  • UVB rays, which help produce vitamin D in the skin, don't reach as far into the skin as UVA rays, but they can still cause sunburn and damage DNA. (
  • Cold compresses applied to the affected skin and analgesic medicines can relieve some of the pain of sunburn. (
  • This is why your skin feels "tight" while experiencing sunburn. (
  • 2. Deep and Meaningful Pty Ltd P.O.Box 427 Ascot Vale Victoria, 3032 AustraliaCauses:  Bacteria (P.Acnes)  Hormones  Genetics  Mixing of cosmetic products  Oily environments(see also Blackheads, Whiteheads, Papules and Pustules) Treatment:  If you work in oily environments ensure proper cleaning to remove all residue from the skin and change affected clothing daily. (
  • Microbes are present across the entire skin surface, but bacterial species vary depending on body site, which is categorized as one of three types: dry, moist, or oily. (
  • Oily or sebaceous skin sites include the trunk, neck, and head. (
  • She advises, "If you are oily use a light lotion, gel or powder and [if you have] dry [skin] use a moisturizing one. (
  • When you browse the Walgreens website, you will find kits that address the issues faced by all types of skin: from dry to oily, youthful to mature. (
  • Sebum is an oily substance that helps keep the skin from drying out. (
  • The formulas are specifically designed to improve skin texture and reduce the look of fine lines, and the study showed their effectiveness: Participants saw visible results immediately, and younger and more radiant-looking skin after four weeks of use. (
  • Regular application of vitamin E oil on skin can bring about marked improvement in texture of the skin. (
  • For normal to dry skin, the spa recommends then following with a Pumpkin Papaya Enzyme Masque Booster to resurface and improve skin texture, prepping skin to more fully absorb the Glacial Hydration Masque, formulated with ocean botanicals to rehydrate and plump fine lines. (
  • By using chicken skin for its texture and powerful flavor in all sorts of dishes, chefs are legitimizing what used to be a guilty pleasure, whether they call it gribenes, yakitori kawa or cracklings. (
  • They also gave a worse assessment of their own skin and facial appearance than people who sleep well. (
  • they just happen randomly for now reason and its driving me crazy.ive asked several people if they know what it is, but when i mention 'stinging in my skin' they just think im crazy.anybody have any ideas? (
  • Some of these problems are skin conditions anyone can have, but people with diabetes get more easily. (
  • Other skin problems happen mostly or only to people with diabetes. (
  • Later in life, these glands produce less sebum, which contributes to dry skin in older people. (
  • Because HIV weakens the immune system , people with AIDS are more likely to suffer health problems, including those of the skin . (
  • People who suffer third-degree burns often require skin grafting. (
  • A direct descendant of Nicolas Roeg's classic 'The Man Who Fell to Earth,' 'Under the Skin' is the kind of movie people will be talking about, and dissecting and puzzling over, for years. (
  • EWG's Skin Deep ® cosmetic database gives people practical solutions to protect themselves and their families from everyday exposures to potentially toxic chemicals in personal care and beauty products. (
  • Chéreau's scrutiny is so patient, intimate, and unyielding that when two people suddenly touch on-screen-all credit to Gautier's practically under-the-skin cinematography-it's as if the viewer is in on the embrace too, salved by an unexpected gesture of tactile solace. (
  • Along with the skills and education you can learn in skin care training, specialists should have people skills and enjoy developing successful client relationships. (
  • People should treat the health of their skin as an integrated component of their overall wellness plan. (
  • People with low Omega-3 levels often struggle with dry skin, which can be particularly challenging in the winter months. (
  • By eating Omega-3 rich foods - such as avocados, walnuts and flaxseeds - people can infuse necessary oils into their skin and reduce dryness. (
  • We want to help people living with chronic skin conditions such as psoriasis to take more control. (
  • The LEO Foundation supports dermatological research projects and activities, and LEO Innovation Lab develops digital solutions to improve the lives of people living with a skin condition. (
  • According to the most recent data available from the Centers for Disease Control and Prevention (CDC), 71,943 people in the United States were diagnosed with melanomas of the skin in 2013. (
  • Variations in this gene play an important role in the expression of lighter skin tones in people of European descent. (
  • Grooming newbies also come to the boards for advice like " a basic routine for most people with average skin . (
  • Now, doctors who specialize in wound management are growing skin to help people like Tomas save their limbs and extremities. (
  • And then there are skin people. (
  • Since scaling the Billboard Hot 100 chart with summer hit " Despacito ," and amassing several hit singles over a multi-decade career, most people think "music" when they think of Daddy Yankee, but his youthful glow at 40 make others think, "great skin. (
  • The only thing I use is organic extra-virgin olive oil," he told People en Espanol in an exclusive interview. (
  • The speed and quality of wound healing in skin is promoted by the reception of estrogen . (
  • Skin grafting is a surgical procedure in which skin or a skin substitute is placed over a burn or non-healing wound. (
  • A skin graft is used to permanently replace damaged or missing skin or to provide a temporary wound covering. (
  • The most important part of any skin graft procedure is proper preparation of the wound. (
  • But when it is damaged, a super-dense form of collagen is created to quickly cover over the wound -- so thick that no hair roots, sweat glands and few nerves can grow in it, and the skin loses functionality. (
  • The collagen from fish skin is being tested as a component of wound dressings that could be cheaper and safer than today's alternatives. (
  • If there is a break in the skin or if the immune system is weakened, then the microbes may cause a wound or skin infection. (
  • In some cases, we can get four football fields of skin out of one baby foreskin,' said Dr. James McGuire, head of wound management at the Foot and Ankle Institute at the School of Podiatric Medicine at Temple University , in Philadelphia. (
  • The patient can't feel anything, so when they step on a tack or get a blister or a penetrating wound to the skin, it just gets infected and keeps festering. (
  • Your days of smooth, radiant, and elastic skin are numbered, and the ticking clock of time and sunlight are to blame. (
  • For defecting skin changes in the dark skinnedpatient, sunlight is the best choice. (
  • Affected skin is also usually sensitive to sunlight. (
  • In fact, sunlight stimulates hormone production, allows for the synthesis of vitamin D, promotes skin cell regeneration and contributes to an overall sense of well-being. (
  • The human skin is remarkably absorbent, for good or ill: Just as it can quickly absorb toxins in the environment, such as chlorine, it can absorb beneficial nutrients, such as natural crystal salts, essential oils, and pH-balanced water. (
  • Exercise is important because it increases blood flow to the skin, which facilitates the removal of toxins while also bringing oxygen and nutrients to the skin," Chwalek says. (
  • For first or second-degree burns, skin grafting is generally not required, as these burns usually heal with little or no scarring. (
  • Beyond its sealing in moisture and helping skin to heal, new research has shown that snail mucin may have anti-aging potential, too. (
  • They are used to address sprains, bruises and sore muscles, cleanse and heal the skin by promoting cell growth, and aid upper respiratory ailments such as bronchitis, asthma, and the common cold. (
  • These injuries heal because our skin is designed to repair itself. (
  • Each TSA-friendly 3oz tube or 16oz pump bottle is packed with Vitamin A & E to strengthen, protect, and heal your skin. (
  • A skin lesion biopsy is when a small amount of skin is removed so it can be examined. (
  • A lesion is an abnormal area of the skin. (
  • If the whole skin lesion was not removed at the time of biopsy, you and your provider may decide to completely remove it. (
  • A skin lesion is a superficial growth or patch of the skin that does not resemble the area surrounding it. (
  • See your GP if you have any skin abnormality, such as a lump, ulcer, lesion or skin discolouration that hasn't healed after four weeks. (
  • A balanced blend of mineral-based compounds, formulated on the basis of scientific research, can replenish and revitalize your skin, restoring its natural suppleness and moisture levels. (
  • The main sign is a red, scaly patch on the skin that may itch. (
  • High levels of UV radiation increase risk Fair skin that freckles or burns easily, blonde/red hair, light eyes greater risk. (
  • Our study is the first to conclusively demonstrate that inadequate sleep is correlated with reduced skin health and accelerates skin aging. (
  • The skinscope allows you to see the health of your skin on a deeper level. (
  • Trust your skin and health to an OHSU provider. (
  • Knowing what laser is the most appropriate to use can only occur when your provider can accurately evaluate your skin and diagnose underlying skin conditions or other potential health issues you may have. (
  • The truth is, skin lightening products can be pose risks to a person's health. (
  • Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. (
  • Note: If you have ever had a "positive" reaction to a TB skin test or if you have been treated with TB drugs in the past, tell the health worker. (
  • Antioxidants also play an important role in the health of one's skin and preparing it for optimal health during the winter months. (
  • Solay 84 Re-mineralizing and Re-hydrating Skin Therapy products can be the key to your natural skin care health! (
  • Bacteria are by far the most common skin microbes, although healthy, normal skin may also be home to fungi, viruses, and mites. (
  • Certain bacteria are referred to as transient, since it is only possible to culture them from skin samples now and then. (
  • These are generally Gram-positive bacteria such as Clostridium , but sometimes the Gram-negative bacteria acinetobacter grows in moist skin areas. (
  • One substance isolated from the skin secretions of the Foothill Yellow-legged Frog - a species once common in California and Oregon but now facing extinction - shows promise for killing methicillin-resistant Staphylococcus aureus (MRSA) bacteria. (
  • A person with a positive skin test along with an abnormal chest X-ray and sputum evidencing TB bacteria has active TB and is contagious. (
  • Avoid over cleansing the skin.For further info go to:-www.skincarephysicians.comAgeing/Mature SkinCharacteristics:  Skin becomes finer and more delicate  Sebum production lessens considerably, which can lead to superficial dehydration. (
  • The thickness of skin also varies from location to location on an organism. (
  • And, depending on the thickness of the graft, the replacement skin can lack certain features of skin, such as pigment, nerves or hairs. (
  • Incorporate skin care tools and devices from CVS into your skin care regimen and be blown away by the results. (
  • There is no reason why a hectic lifestyle should mean you need to compromise on your skin care regimen. (
  • Treat the recipient to a fresh take on her skin care regimen and allow him or her to experience a brand or range that she has not used before. (
  • Hair is actually a modified type of skin. (
  • Like hair, nails are a type of modified skin - and they're not just for beauty. (
  • An autograft is a type of graft that uses skin from another area of the patient's own body if there is enough undamaged skin available, and if the patient is healthy enough to undergo the additional surgery required. (
  • Which skin type is it good for? (
  • Dr. Jaliman advises, "The only way you can pick the right sunscreen is to know your skin type. (
  • Depending on what you are trying to achieve in your skin care routine, depends on the type of skin care tools you need. (
  • choose the cosmetics that suit your skin type or go for natural skin care. (
  • By investing in a skin care care set, you will have the opportunity to use a complete range of products that have been specially developed for your skin type. (
  • If you know that a relative, friend or colleague would like to update his or her beauty routine, consider giving him or her a skin care set that targets her skin type. (
  • For summer skin, the spa recommends the Cornelia Signature Facial, which, depending on your skin type, can offer as many as three reparative boosters utilizing vitamins, antioxidants, plant-driven proteins, firming botanicals and amino acids. (
  • The herbs in the treatment are customized according to the individuals' dosha and skin type, and contain purifying, cooling, calming, balancing and detoxifying properties. (
  • The device can fabricate healthy skin in anywhere from minutes to a few hours, depending on the size and type of burn, according to the report. (
  • Another tip from Dr. Jaliman is to look for a sunscreen with physical blockers including zinc oxide and titanium dioxide, which won't irritate sensitive skin. (
  • Jade rollers have been used since ancient times to massage the skin and reduce puffiness. (
  • The adjective cutaneous means "of the skin" (from Latin cutis , skin). (
  • Rare lymphomas that start in the skin are called skin lymphomas (or cutaneous lymphomas). (
  • Eyelids have the thinnest skin, the soles of our feet the thickest. (
  • In the work environment, skin trauma and mechanical affections of the hands are aggravating factors of psoriasis. (
  • Following this letter she created a blog entitled Being Me In My Own Skin where she gives intimate details of what it's like to live with psoriasis. (
  • Based on the novel by Michel Faber (The Crimson Petal and the White), UNDER THE SKIN examines human experience from the perspective of an unforgettable heroine who grows too comfortable in her borrowed skin, until she is abducted into humanity with devastating results. (
  • Main roles: makes sweat and oil, provides sensations and blood to the skin, grows hair. (
  • As the number of full-service spas grows, many job opportunities are being created for skin care specialists. (
  • As the new skin grows, the cowhide and shark substances from the artificial skin are broken down and absorbed by the body. (
  • Are you looking for younger, smoother skin? (
  • Looking for tighter, younger looking skin? (
  • This article gives you simple methods on how to prepare salt scrubs at home, for a younger and glowing skin. (
  • Dry skin is less common in teenagers than younger children. (
  • These products do not even scrape the surface of all of the different skin care tools that we have to offer. (