A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.
A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.
Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Single layer of large flattened cells covering the surface of the cornea.
An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.
Immunologic techniques involved in diagnosis.
Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)
Soft, supple contact lenses made of plastic polymers which interact readily with water molecules. Many types are available, including continuous and extended-wear versions, which are gas-permeable and easily sterilized.
Sterile solutions used to clean and disinfect contact lenses.
Inflammation of the cornea.
Infection of the cornea by an ameboid protozoan which may cause corneal ulceration leading to blindness.
Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.
Absent or reduced sensitivity to cutaneous stimulation.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
An instrument for reproducing sounds especially articulate speech at a distance. (Webster, 3rd ed)
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Antibodies produced by a single clone of cells.

A lipid modified ubiquitin is packaged into particles of several enveloped viruses. (1/4686)

An anti-ubiquitin cross-reactive protein which migrates more slowly (6.5 kDa) by SDS-PAGE than ubiquitin was identified in African swine fever virus particles. This protein was extracted into the detergent phase in Triton X-114 phase separations, showing that it is hydrophobic, and was radiolabelled with both [3H]palmitic acid and [32P]orthophosphate. This indicates that the protein has a similar structure to the membrane associated phosphatidyl ubiquitin described in baculovirus particles. A similar molecule was found in vaccinia virus and herpes simplex virus particles, suggesting that it may be a component of uninfected cell membranes, which is incorporated into membrane layers in virions during morphogenesis.  (+info)

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. (2/4686)

Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections or tissue injuries. We show that the ability of a virus or a tissue injury to increase MHC gene expression is duplicated by any fragment of double-stranded (ds) DNA or dsRNA introduced into the cytoplasm of nonimmune cells. Activation is sequence-independent, is induced by ds polynucleotides as small as 25 bp in length, and is not duplicated by single-stranded polynucleotides. In addition to causing abnormal MHC expression, the ds nucleic acids increase the expression of genes necessary for antigen processing and presentation: proteasome proteins (e.g., LMP2), transporters of antigen peptides; invariant chain, HLA-DM, and the costimulatory molecule B7.1. The mechanism is different from and additive to that of gamma-interferon (gammaIFN), i.e., ds polynucleotides increase class I much more than class II, whereas gammaIFN increases class II more than class I. The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN. CpG residues are not responsible for this effect, and the action of the ds polynucleotides could be shown in a variety of cell types in addition to thyrocytes. We suggest that this phenomenon is a plausible mechanism that might explain how viral infection of tissues or tissue injury triggers autoimmune disease; it is potentially relevant to host immune responses induced during gene therapy.  (+info)

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish. (3/4686)

The most common way to analyze the function of cloned genes in zebrafish is to misexpress the gene product or an altered variant of it by mRNA injection. However, mRNA injection has several disadvantages. The GAL4-UAS system for targeted gene expression allows one to overcome some of these disadvantages. To test the GAL4-UAS system in zebrafish, we generated two different kinds of stable transgenic lines, carrying activator and effector constructs, respectively. In the activator lines the gene for the yeast transcriptional activator GAL4 is under the control of a given promoter, while in the effectors the gene of interest is fused to the sequence of the DNA-binding motif of GAL4 (UAS). Crosses of animals from the activator and effector lines show that effector genes are transcribed with the spatial pattern of the activators. This work smoothes the way for a novel method of misexpression of gene products in zebrafish in order to analyze the function of genes in developmental processes.  (+info)

A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function. (4/4686)

The herpes simplex virus type 1 gamma34.5 gene product and the cellular GADD34 protein both contain similar domains that can regulate the activity of eukaryotic initiation factor 2 (eIF2), a critical translation initiation factor. Viral mutants that lack the GADD34-related function grow poorly on a variety of malignant human cells, as activation of the cellular PKR kinase leads to the accumulation of inactive, phosphorylated eIF2 at late times postinfection. Termination of translation prior to the completion of the viral reproductive cycle leads to impaired growth. Extragenic suppressors that regain the ability to synthesize proteins efficiently in the absence of the viral GADD34-related function have been isolated. These suppressor alleles are dominant in trans and affect the steady-state accumulation of several viral mRNA species. We demonstrate that deregulated expression of Us11, a virus-encoded RNA-binding, ribosome-associated protein is necessary and sufficient to confer a growth advantage upon viral mutants that lack a GADD34-related function. Ectopic expression of Us11 reduces the accumulation of the activated cellular PKR kinase and allows for sustained protein synthesis. Thus, an RNA-binding, ribosome-associated protein (Us11) and a GADD34-related protein (gamma34.5) both function in a signal pathway that regulates translation by modulating eIF2 phosphorylation.  (+info)

Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing. (5/4686)

We have reported recently that a small element within the mouse histone H2a-coding region permits efficient cytoplasmic accumulation of intronless beta-globin cDNA transcripts. This sequence lowers the levels of spliced products from intron-containing constructs and can functionally replace Rev and the Rev-responsive element (RRE) in the nuclear export of unspliced HIV-1-related mRNAs. In work reported here, we further investigate the molecular mechanisms by which this element might work. We demonstrate here through both in vivo and in vitro assays that, in addition to promoting mRNA nuclear export, this element acts as a polyadenylation enhancer and as a potent inhibitor of splicing. Surprisingly, two other described intronless mRNA transport elements (from the herpes simplex virus thymidine kinase gene and hepatitis B virus) appear to function in a similar manner. These findings prompt us to suggest that a general feature of intronless mRNA transport elements might be a collection of phenotypes, including the inhibition of splicing and the enhancement of both polyadenylation and mRNA export.  (+info)

Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. (6/4686)

To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the cDNA for an opioid peptide precursor, human preproenkephalin, under control of the human cytomegalovirus promoter. This virus and a similar recombinant containing the Escherichia coli lacZ gene were applied to the abraded skin of the dorsal hindpaw of mice. After infection, the presence of beta-galactosidase in neuronal cell bodies of the relevant spinal ganglia (lacZ-containing virus) and of human proenkephalin (preproenkephalin-encoding virus) in the central terminals of these neurons indicated appropriate gene delivery and expression. Baseline foot withdrawal responses to noxious radiant heat mediated by Adelta and C fibers were similar in animals infected with proenkephalin-encoding and beta-galactosidase-encoding viruses. Sensitization of the foot withdrawal response after application of capsaicin (C fibers) or dimethyl sulfoxide (Adelta fibers) observed in control animals was reduced or eliminated in animals infected with the proenkephalin-encoding virus for at least 7 weeks postinfection. Hence, preproenkephalin cDNA delivery selectively blocked hyperalgesia without disrupting baseline sensory neurotransmission. This blockade of sensitization was reversed by administration of the opioid antagonist naloxone, apparently acting in the spinal cord. The results demonstrate that the function of sensory neurons can be selectively altered by viral delivery of a transgene. Because hyperalgesic mechanisms may be important in establishing and maintaining neuropathic and other chronic pain states, this approach may be useful for treatment of chronic pain and hyperalgesia in humans.  (+info)

Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer. (7/4686)

Adenovirus-mediated transduction of the herpes simplex thymidine kinase gene (HSV-tk) in conjunction with ganciclovir (GCV) has been shown to result in significant growth suppression and to enhance survival in a model of mouse prostate cancer. However, this therapeutic activity is not sustained, because in most cases tumors eventually regrow and ultimately cause the death of the host. Androgen ablation, an inducer of apoptosis in prostate cells which is used widely as palliative therapy in patients with prostate cancer, was combined with HSV-tk plus GCV using an androgen-sensitive mouse prostate cancer cell line. The combination of castration and HSV-tk plus GCV led to markedly enhanced tumor growth suppression in both subcutaneous and orthotopic models compared with either treatment alone and resulted in an enhanced survival in which combination-treated animals lived twice as long as controls in the subcutaneous model and over 50% longer than controls in the orthotopic model. Further analysis of apoptotic activity demonstrated high levels of apoptosis only in combined androgen ablation and HSV-tk plus GCV-treated tumors after 14 days of growth in an androgen-depleted environment and 8 days after HSV-tk plus GCV therapy. At this time, the apoptotic index, but not the percent of necrotic tissue, was significantly higher for combination therapy-treated tumors relative to control-treated tumors or either treatment alone. These data indicate that the therapeutic effects of androgen ablation and HSV-tk plus GCV are cooperative and that increased apoptosis may, in part, underlie these activities.  (+info)

Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. (8/4686)

We initially identified c-myc promoter binding protein 1 (MBP-1), which negatively regulates c-myc promoter activity, from a human cervical carcinoma cell expression library. Subsequent studies on the biological role of MBP-1 demonstrated induction of cell death in fibroblasts and loss of anchorage-independent growth, reduced invasive ability, and tumorigenicity of human breast carcinoma cells. To investigate the potential role of MBP-1 as a transcriptional regulator, a chimeric protein containing MBP-1 fused to the DNA binding domain of the yeast transactivator factor GAL4 was constructed. This fusion protein exhibited repressor activity on the herpes simplex virus thymidine kinase promoter via upstream GAL4 DNA binding sites. Structure-function analysis of mutant MBP-1 in the context of the GAL4 DNA binding domain revealed that MBP-1 transcriptional repressor domains are located in the N terminus (amino acids 1 to 47) and C terminus (amino acids 232 to 338), whereas the activation domain lies in the middle (amino acids 140 to 244). The N-terminal domain exhibited stronger transcriptional repressor activity than the C-terminal region. When the N-terminal repressor domain was transferred to a potent activator, transcription was strongly inhibited. Both of the repressor domains contained hydrophobic regions and had an LXVXL motif in common. Site-directed mutagenesis in the repressor domains indicated that the leucine residues in the LXVXL motif are required for transcriptional repression. Mutation of the leucine residues in the common motif of MBP-1 also abrogated the repressor activity on the c-myc promoter. In addition, the leucine mutant forms of MBP-1 failed to suppress cell growth in fibroblasts like wild-type MBP-1. Taken together, our results indicate that MBP-1 is a complex cellular factor containing multiple transcriptional regulatory domains that play an important role in cell growth regulation.  (+info)

TY - JOUR. T1 - Role of protein-protein interactions during herpes simplex virus type I recombination-dependent replication. AU - Nimonkar, Amitabh V.. AU - Boehmer, Paul E.. PY - 2004/5/21. Y1 - 2004/5/21. N2 - Recombination-dependent replication is an integral part of the process by which double-strand DNA breaks are repaired to maintain genome integrity. It also serves as a means to replicate genomic termini. We reported previously on the reconstitution of a recombination-dependent replication system using purified herpes simplex virus type 1 proteins (Nimonkar A. V., and Boehmer, P. E. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10201-10206). In this system, homologous pairing by the viral single-strand DNA-binding protein (ICP8) is coupled to DNA synthesis by the viral DNA polymerase and helicase-primase in the presence of a DNA-relaxing enzyme. Here we show that DNA synthesis in this system is dependent on the viral polymerase processivity factor (UL42). Moreover, although DNA synthesis is ...
TY - JOUR. T1 - Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41. AU - Smibert, C. A.. AU - Johnson, David. AU - Smiley, J. R.. PY - 1992. Y1 - 1992. N2 - The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.. AB - The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in ...
A 33-year-old man developed Herpesvirus hominis type 2 (HVH-2) eye disease following a herpetic lesion of the penis. The sequence of ocular involvement suggested that the virus had been transmitted endogenously from the genital lesion: granulomatous iritis was followed by interstitial keratitis and then by dendritic keratitis. Recurrent bacterial ulcers ultimately required a conjunctival flap. The course of this mans ocular disease as well as those of other reported cases of HVH-2 adult eye infections appeared to be more severe and prolonged than that of the average patient with ocular herpes type 1 infection. ...
TY - JOUR. T1 - Herpes simplex virus glycoproteins gD and gE/gI serve essential but redundant functions during acquisition of the virion envelope in the cytoplasm. AU - Farnsworth, Aaron. AU - Goldsmith, Kimberly. AU - Johnson, David C.. PY - 2003/8/1. Y1 - 2003/8/1. N2 - The late stages of assembly of herpes simplex virus (HSV) and other herpesviruses are not well understood. Acquisition of the final virion envelope apparently involves interactions between viral nucleocapsids coated with tegument proteins and the cytoplasmic domains of membrane glycoproteins. This promotes budding of virus particles into cytoplasmic vesicles derived from the trans-Golgi network or endosomes. The identities of viral membrane glycoproteins and tegument proteins involved in these processes are not well known. Here, we report that HSV mutants lacking two viral glycoproteins, gD and gE, accumulated large numbers of unenveloped nucleocapsids in the cytoplasm. These aggregated capsids were immersed in an ...
Also known as fever blisters when they last three to four weeks. No intimate contact herpes simplex 1 symptoms hiv with family and friends usually infect children before the age of 12. Cold sore cures are very infectious! It is so easy now to know the feeling. All diseases are based on the whole infection event, your body. tricks to get rid of cold sores healing When the virus at one time of healing depends upon several creams and remedy at the virus. A Copy Click here ==> Cold Sore Without Liquid Foundation? Begin eating more difficult for your pain. Colds, flu or other products on the active info on herpes simplex virus pertaining to abstain intimate contagious, and you stand a info on herpes simplex virus good start taking l-lysine tablets internally should not work well, get enough sleep and poor skin care routine designed from the aloe a couple of days remedies for canker sores children more. The bodys immune system, amongst individuals apply pressure by pricking it. But it does not work ...
Summary Both herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of Δ-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed.
TY - JOUR. T1 - Function of herpes simplex virus gene products. AU - Nishiyama, Y.. AU - Murata, Takayuki. AU - Yamauchi, Y.. PY - 2001/1/1. Y1 - 2001/1/1. UR - http://www.scopus.com/inward/record.url?scp=0035380417&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0035380417&partnerID=8YFLogxK. U2 - 10.2222/jsv.51.29. DO - 10.2222/jsv.51.29. M3 - Review article. C2 - 11565262. AN - SCOPUS:0035380417. VL - 51. SP - 29. EP - 36. JO - Uirusu. Journal of virology. JF - Uirusu. Journal of virology. SN - 0042-6857. IS - 1. ER - ...
Objectives: To document the natural history of herpes simplex virus type 2 (HSV-2) in relation to HIV and highly active antiretroviral therapy (HAART) in Africa, a longitudinal study was conducted of women in the placebo arms of two randomised controlled trials of HSV-suppressive therapy in Burkina Faso. Methods: 22 HIV-uninfected women (group 1), 30 HIV-1-infected women taking HAART (group 2), and 68 HIV-1-infected women not eligible for HAART (group 3) were followed over 24 weeks. HSV-2 DNA was detected on alternate weeks using real-time PCR from cervicovaginal lavages. Plasma HIV-1 RNA was measured every month. CD4 cell counts were measured at enrolment. Results: Ulcers occurred on 1.9%, 3.1% and 7.2% of visits in groups 1, 2 and 3 (p = 0.02). Cervicovaginal HSV-2 DNA was detected in 45.5%, 63.3% and 67.6% of women (p = 0.11), and on 4.3%, 9.7% and 15.5% of visits in the three groups (p ...
TY - JOUR. T1 - Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells. AU - Taneja, Samir. AU - MacGregor, Jennifer. AU - Markus, Steven. AU - Ha, Susan. AU - Mohr, Ian. PY - 2001/7/17. Y1 - 2001/7/17. N2 - Replication-competent, attenuated herpes simplex virus-1 (HSV-1) derivatives that contain engineered mutations into the viral γ34.5 virulence gene have been used as oncolytic agents. However, as attenuated mutants often grow poorly, they may not completely destroy some tumors and surviving cancer cells simply regrow. Thus, although HSV-1 γ34.5 mutants can reduce the growth of human tumor xenografts in mice and have passed phase 1 safety studies, their efficacy is limited because they replicate poorly in many human tumor cells. Previously, we selected for a γ34.5 deletion mutant variant that regained the ability to replicate efficiently in tumor cells. Although this virus contains an extragenic suppressor mutation that confers enhanced ...
Author Summary Herpes simplex virus type 1 (HSV-1) is a ubiquitous virus that can cause cold sores, blindness, and even death from encephalitis. There is no vaccine against HSV, and although antiviral drugs can control HSV-1, it persists because it establishes lifelong latent infections in neurons. Humans with deficiencies in innate immunity have significant problems controlling HSV infections. In this study we therefore sought to elucidate the role of neuronal innate immunity in the control of viral infection. Sensory neurons, in which HSV resides, have projection which that extend long distances to innervate the skin, the initial site of HSV infection. We found that neurons can respond to interferon beta, a molecule that strongly stimulates innate immunity and inhibits virus growth, at both the cell body and at the end of these long projections. Moreover, we found that this interferon response of neurons is critical for controlling HSV infection in vivo and that the interferon responses of non
We have shown previously that a novel herpes simplex virus-induced activity, LPF, selectively increases RNA 3-end processing at the poly(A) site of a late virus gene (J. McLauchlan, S. Simpson, and J. B. Clements, Cell 59:1093-1105, 1989). Here, our in vivo and in vitro analyses both demonstrate that LPF is induced during early stages of virus infection. Studies of virus mutants indicate that expression of the immediate-early IE63 gene is required for induction of this activity. The selective effects on 3 processing displayed in the presence of IE63 provide direct evidence that IE63 can influence this posttranscription process. This extends previous studies which reported increases in reporter gene activity with certain poly(A) sites by IE63 (R. M. Sandri-Goldin and G. E. Mendoza, Genes Dev. 6:848-863, 1992). ...
Herpes simplex viruses cause considerable morbidity and mortality. They undergo a lytic, productive infection at the mucosal sites and spread into sensory gangl...
Herpes simplex virus ICP27 protein. Computer model showing the structure of Herpes simplex virus 1 protein ICP27, a multifunctional regulatory protein (purple, magenta). - Stock Image C035/6254
Efficient, accurate and convenient foreign-gene insertion strategies are crucial for the high-throughput and rapid construction of large DNA viral vectors, but relatively inefficient and labour-intensive methods have limited the application of recombinant viruses. In this study, we applied the nonhomologous insertion (NHI) strategy, which is based on the nonhomologous end joining (NHEJ) repair pathway. Compared to the currently used homologous recombination (HR) strategy, we obtained a higher efficiency of foreign-gene insertion into the herpes simplex virus (HSV) genome that reached 45 % after optimization. By using NHI, we rapidly constructed recombinant reporter viruses using a small amount of clinical viruses, and the recombinant virus was stable for at least ten consecutive passages. The fidelity of NHI ranged from 70-100% and was related to the sequence background of the insertion site according to the sequencing results. Finally, we depict the dynamic process by which the foreign-gene donor
Glycoprotein D (gD) of HSV has been shown to be a potent immunogen. To analyze the T cell antigenic determinants on gD, a series of 28 overlapping 20-mer peptides that span the extracellular portion of gD-1 were examined for their ability to stimulate T cells from rgD-1 or infectious HSV-1-primed H-2d mice in vitro. rgD-1-primed cells responded exclusively to peptide 241-260, the immunodominant determinant of gD in H-2d mice. In contrast, infectious HSV-primed T cells were shown to respond to 17 (and up to 22) of 28 synthetic gD peptides. These results indicate an extensive diversity in the T cell repertoire to gD in H-2d mice with T cells directed to a broad array of peptide determinants being recruited during the acute phase of an HSV infection. ...
Summary The hybridization properties of the herpes simplex virus type 1 (HSV) genome have been analysed. The DNA has a kinetic complexity of 1 × 10-8. E. coli RNA polymerase was found to initiate synthesis at about 70 sites on the HSV DNA. The in vitro RNA product from this reaction was complementary to about 80% of the HSV genome. The RNA-DNA hybridization rate constant (K h ) was determined using conditions of both RNA excess and DNA excess. Using this rate constant one can analyse the content of HSV sequences in any RNA population.
Sigma-Aldrich offers abstracts and full-text articles by [Zhihua Li, Yanwei Bi, Hongjian Xiao, Le Sun, Yuan Ren, Yadong Li, Chen Chen, Wei Cun].
This post discusses the herpes virus family and focuses on herpes simplex virus type 1 and type 2, including transmission, elimination, and prevention.
Herpes simplex virus type I (HSV-I) and herpes simplex virus type II (HSV-II) are closely related viruses that cause two distinct clinical syndromes, with some overlap in the roles of the two viruses in each syndrome. Infection with HSV-I causes oral lesions (cold sores, although not all cold sores are due to HSV-I) and is [...]. ...
人Anti-Herpes simplex virus Type 2 IgM ELISA试剂盒(HSV2) ELISA试剂盒datasheet (ab108740).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
Seven herpes simplex virus (HSV) genes have been shown recently to be necessary and sufficient to support the replication of origin-containing plasmids. Two of these genes (pol and dbp) encode well-known DNA replication proteins (the DNA polymerase and the major single-stranded DNA binding protein), and a third gene (UL42) encodes a previously identified infected-cell protein which binds tightly to double-stranded DNA. The products of the four remaining genes have not previously been identified. Using the predicted amino acid sequence data (D.J. McGeoch, M.A. Dalrymple, A. Dolan, D. McNab, L.J. Perry, P. Taylor, and M.D. Challberg, J. Virol. 62:444-453; D.J. McGeoch and J.P. Quinn, Nucleic Acids Res. 13:8143-8163), we have raised rabbit antisera against the products of all seven genes. We report here the use of these reagents to identify these proteins in infected cells. All seven proteins localized to the nucleus and were expressed in a manner consistent with the idea that they are the products ...
We have determined the DNA sequence of the long repeat region (RL) in the genome of herpes simplex virus type 1 (HSV-1) strain 17, as 9215 bp of composition 71.6% G + C. In addition, the sequences of parts of the long unique region (UL) adjacent to the terminal (TRL) and internal (IRL) copies of RL …
Researchers led by John F. DiPersio, MD, PhD, at the School of Medicine have designed a way to mitigate graft-versus-host disease, a common and often life-threatening complication of bone marrow transplants that are used to treat leukemia and other blood cancers. The method also employs a molecular imaging tool to help doctors identify patients most likely to develop this dangerous condition ...
TY - JOUR. T1 - An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1. AU - Mao, Hanwen. AU - Rosenthal, Kenneth S.. PY - 2002/3/29. Y1 - 2002/3/29. N2 - The ICP34.5 protein facilitates herpes simplex virus replication by binding and activating protein phosphatase 1 (PP1) by means of a very conserved C-terminal GADD34-like region. Natural variants of the ICP34.5 differing in the number of arginines in an Arg-rich cluster at the N terminus and the number of Pro-Ala-Thr repeats in the central bridge region of the protein were cloned as fusion proteins with a reporter peptide (c-Myc or hrGFP) at the C terminus. The natural variants were obtained from strains differing in passage history, tissue culture behavior, and neuroinvasive disease potential. In transfected cells, these variants localized to different subcellular compartments. The N-terminal ...
We describe the development of a quantitative, easily automated HSV PCR system for the detection of HSV DNA in clinical samples. The assay was able to detect as few as 10 copies of HSV DNA. The linear range of the assay was from 10 to 108 copies; the assay variability was less than 3%. This non-gel-based technique has several advantages over our previous QC agarose gel-based technique (8). First, this system allows a large increase in throughput. The fluorescent probe assay is run in a 96-well format, and many of the steps in the assay are automated. Second, the assay is a closed system in which the tube is never opened postamplification. Third, it uses an automated detection system that quantitates and calculates the degree of fluorescence over that for the control at each cycle and, hence, accurately defines the cycle number and linear range for a positive result. Finally, the inclusion of the internal control dye (ROX) in every reaction mixture allows the PCR machine to normalize the ...
In the studies conducted, arginine deficiency suppressed herpes simplex virus replication in tissue culture. Lysine, an analog of arginine, as an antimetabolite, antagonized the viral growth-promoting action of arginine. The in vitro data may be the basis for the observation that patients prone to h …
We have shown that T cells inactivated by HSV or HSV-infected fibroblasts have profound inhibition in multiple TCR signaling intermediates as well as multiple downstream defects in effector functions. The reduced levels of tyrosine-phosphorylated LAT, which is critical for TCR signal transduction, may provide a mechanistic explanation for this observed phenotype. Entry of virus into T cells or transfer of a factor from HSV-infected cells is required for this inactivation, but within the T cell, viral replication and viral gene expression are not required. The simplest interpretation of these results is that an HSV virion component is responsible for the reduced levels of phosphorylated LAT. TPI were shown to restore T cell activation, suggesting that the inhibition of TCR signaling by HSV may result from a viral phosphatase or from activation or recruitment of a cellular phosphatase.. One example of modulation of cellular phosphorylation by HSV is the ICP34.5 protein. ICP34.5 is a virion protein ...
Previous studies have indicated that the U(L)6, U(L)15, U(L)17, U(L)28, U(L)32, and U(L)33 genes are required for the cleavage and packaging of herpes simplex viral DNA. To identify proteins that interact with the U(L)28-encoded DNA binding protein of herpes simplex virus type 1 (HSV-1), a previously undescribed rabbit polyclonal antibody directed against the U(L)28 protein fused to glutathione S-transferase was used to immunopurify U(L)28 and the proteins with which it associated. It was found that the antibody specifically coimmunoprecipitated proteins encoded by the genes U(L)28, U(L)15, and U(L)33 from lysates of both HEp-2 cells infected with HSV-1(F) and insect cells infected with recombinant baculoviruses expressing these three proteins. In reciprocal reactions, antibodies directed against the U(L)15- or U(L)33-encoded proteins also coimmunoprecipitated the U(L)28 protein. The coimmunoprecipitation of the three proteins from HSV-infected cells confirms earlier reports of an association ...
Dr. Glorioso began his academic career at the University of Michigan Medical School where he became Professor of Microbiology and Immunology and Assistant Dean for Research and Graduate Studies. In 1989, Dr. Glorioso moved to the University of Pittsburgh School of Medicine to become the William S. McElroy Professor of Biochemistry and Chairman of the Department of Molecular Genetics and Biochemistry, a position he held until 2009. He continues to be a professor in this department.. Dr. Glorioso has established a 40-year history of research related to the basic pathobiology, immunology and genetics of herpes simplex virus (HSV). His contributions to the field include defining antiviral immune responses to infection, the genetics of viral pathogenesis and latency, and mechanisms of viral infection. Furthermore, he has been a pioneer in the design and application of HSV gene vectors for the treatment of nervous system diseases such as peripheral neuropathies, chronic pain, and brain tumors. He ...
HSV模型通常用于计算机图形应用中。在用户必须选择一个颜色应用于特定图形元素各种应用环境中,经常使用HSV ...
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Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Bromine atom in PDB 1ki8: Crystal Structure of Thymidine Kinase From Herpes Simplex Virus Type I Complexed With 5-Bromovinyldeoxyuridine
Feline herpesvirus type-1 (FHV-1) is a common cause of respiratory and eye disease in cats. Im mostly recovered now but it really sucked a lot out of me and itll be a couple of weeks at the gym before I have the energy I did before I got sick. If you would like to acquire more info pertaining to famvir kindly visit Pharmacy Lookup. Herpes simplex virus (HSV) infection is a highly prevalent condition responsible for significant morbidity and occasional mortality each year. Regardless of the dose of drug used, all groups exhibited the high rates of spontaneous and induced reactivation characteristic of 17syn+. Famciclovir (FCV) is efficacious in the treatment of acute herpes zoster and recurrent genital infections but has not been used to treat ocular herpes simplex virus (HSV) infections. He lifted himself up on or the Ryan family had come to the White House, with a total as a dirt road and rattled over a cattle crossing.. Is used to: Generic Famvir is used for treating herpes zoster infection ...
How to Treat Herpes - Herpes is a kind of infection which is caused through the herpes simplex virus. Herpes virus can be classified into two parts such as herpes simplex virus 1 & herpes simplex virus 2. Herpes simplex virus 1 leads to oral form of herpes whereas herpes simplex virus 2 leads to…
HERPES SIMPLEX. What are the aims of this leaflet?. This leaflet has been written to help you understand more about herpes simplex. It tells you what it is, what causes it, what can be done about it, and where you can find out more about it.. What is herpes simplex?. Herpes simplex is an infection of the skin with the herpes simplex virus. There are two types of herpes virus, called herpes simplex type 1 and herpes simplex type 2. Herpes infection is caught from another person through contact with mouth, eye or genital secretions or through direct contact with an active lesion. Herpes simplex type 1 usually infects the mouth or eye and herpes simplex type 2 usually infects the genital area. After the virus infects the person, whether it shows on the skin or not, it goes to local sensory nerves and lies hidden (dormant) until reactivation (recurrence of the herpes infection). Reactivation can occur after a few weeks or even years, when the virus travels to the skin supplied by the nerve and ...
TY - JOUR. T1 - Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity. AU - Herold, B. C.. AU - WuDunn, D.. AU - Soltys, N.. AU - Spear, P. G.. PY - 1991. Y1 - 1991. N2 - The purpose of this study was to identify the herpes simplex virus glycoprotein(s) that mediates the adsorption of virions to cells. Because heparan sulfate moieties of cell surface proteoglycans serve as the receptors for herpes simplex virus adsorption, we tested whether any of the viral glycoproteins could bind to heparin-Sepharose in affinity chromatograpby experiments. Two glycoproteins, gB and gC, bound to heparin-Sepharose and could be eluted with soluble heparin. In order to determine whether virions devoid of gC or gB were impaired for adsorption, we quantitated the binding of wild-type and mutant virions to cells. We found that at equivalent input concentrations of purified virions, significantly fewer gC-negative virions bound to cells than did ...
TY - JOUR. T1 - Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas. AU - Rath, Prakash. AU - Shi, Huidong. AU - Maruniak, Joel A.. AU - Litofsky, N. Scott. AU - Maria, Bernard L.. AU - Kirk, Mark D.. PY - 2009/10/12. Y1 - 2009/10/12. N2 - The prognosis of patients diagnosed with malignant gliomas including glioblastoma multiforme (GBM) is poor and there is an urgent need to develop and translate novel therapies into the clinic. Neural stem cells display remarkable tropism toward GBMs and thus may provide a platform to deliver oncolytic agents to improve survival. First we provide a brief review of clinical trials that have used intra-tumoral herpes simplex virus thymidine kinase (HSV/tk) gene therapy to treat brain tumors. Then, we review recent evidence that neural stem cells can be used to deliver HSV/tk to GBMs in animal models. While previous clinical trials used viruses or non-migratory vector-producing cells to deliver HSV/tk, the latter approaches were not ...
Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) belong to a family of DNA viruses that include cytomegalovirus (CMV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (Table 309-1). Following primary infection, herpes simplex viruses establish a latent state, in general, HSV-1 in the trigeminal ganglion and HSV-2 in the sacral ganglion. From time to time, the viruses may be reactivated, resulting in recurrent infections that may or may not be associated with symptoms. HSV-1 is usually transmitted in oral secretions, whereas HSV-2 is most often transmitted through sexual activity. HSV-1 infections occur most frequently during childhood and usually affect body sites above the waist (mouth, lips, eyes, face). HSV-2 infections occur most often during adolescence and adulthood, and involve body sites below the waist (genitalia, buttocks, thighs). Historically, the majority of infections in newborns is transmitted from the maternal ...
Request a free sample report @https://www.delveinsight.com/sample-request/herpes-simplex-market. Table of Contents. 1. Report Introduction. 2. Executive Summary. 3. SWOT analysis. 4. Herpes Simplex Patient Share (%) Overview at a Glance. 5. Herpes Simplex Market Overview at a Glance. 6. Herpes Simplex Disease Background and Overview. 7. Herpes Simplex Epidemiology and Patient Population. 8. Country-Specific Patient Population of Herpes Simplex 9. Herpes Simplex Current Treatment and Medical Practices. 10. Unmet Needs. 11. Herpes Simplex Emerging Therapies. 12. Herpes Simplex Market Outlook. 13. Country-Wise Herpes Simplex Market Analysis (2017-2030). 14. Market Access and Reimbursement of Therapies. 15. Market drivers. 16. Market barriers. 17. Appendix. 18. Herpes Simplex Report Methodology. 19. DelveInsight Capabilities. 20. Disclaimer. 21. About DelveInsight. Related Reports:. Herpes Simplex- Pipeline Insights, 2021. Herpes Simplex- Pipeline Insight, 2021 report by DelveInsight outlines ...
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TY - JOUR. T1 - Murine IgG subclass responses to herpes simplex virus type 1 and polypeptides. AU - McKendall, R. R.. AU - Woo, W.. PY - 1988. Y1 - 1988. N2 - The antibody response to herpes simplex virus (HSV) is complex and involves antibody to at least 33 virus-induced polypeptides. Serum IgG contains four isotypes in mice and it is known that the isotypes differ in their biological functions and that individual antigenic proteins may preferentially elicit restricted isotype responses. We therefore examined the anti-polypeptide isotypes induced in immune mouse serum. By ELISA, we found that the total serum virus-specific antibody activity was 51% IgG1, 39% IgG2a, 11% IgG2b and 1% IgG3 in immune ICR strain mice and 51%, 45%, 4% and 0.4% respectively in strain BALB/c mouse immune serum. These proportions are significantly different from those reported for other virus infections. Sepharose-Protein A affinity-purified isotypes were also studied and showed IgG1 , IgG2a ≥ IgG2b ≥ IgG3 activity ...
Genital Herpes Symptoms. Learn about genital herpes symptoms, genital herpes treatment options, and how to manage your herpes simplex outbreaks. Signs of herpes tend to develop within 3-7 days of skin-to-skin contact with an infected person. Valuable informations about Herpes Simplex Virus Infection at Genital | Herpes | Facts
TY - JOUR. T1 - Purification of a set of cellular polypeptides that bind to the purine-rich cis-regulatory element of herpes simplex virus immediate early genes.. AU - LaMarco, K. L.. AU - McKnight, S. L.. N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. PY - 1989/9. Y1 - 1989/9. N2 - Expression of herpes simplex virus type 1 (HSV1) immediate early (IE) genes is activated by a polypeptide component of the mature virion termed viral protein 16 (VP16). Stimulation of IE expression by VP16 operates via two cis-regulatory sequences: TAATGARAT, and the purine-rich hexanucleotide sequence GCGGAA. VP16 does not bind directly to either of the IE cis-regulatory sequences. Rather, these elements appear to represent binding sites for host cell proteins. Herein, we report the purification of a host cell factor that binds to the GCGGAA motif. We show further that this factor is capable of binding in vitro to an oligomerized form of the ...
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HerpesSimplex Virus. InstitutionAffiliation:. Herpessimplex virus causes a common infection known as herpes. The viruscausing the infection can either be herpes simplex virus type 1(HSV-1) or herpes simplex virus type 2 (HSV-2). Transmission of HSV-1is via mouth-mouth touch and it causes oral herpes (oral-labial ororal-facial herpes). HSV-2 is transmitted via sexual contact to causean infection in the anal or genital area. HSV-2 causes an infectionknown as genital herpes. However, people can transmit HSV-1 to thegenital area through oral to genital contact hence causing genitalherpes. The two infections are mostly asymptomatic, but they can leadto less severe symptoms, ulcers or painful blisters at the infectedareas (World Health Organization, 2017).. HSV-1infection is common, highly contagious and endemic throughout theworld. Most of the infections are lifelong and acquired duringchildhood. Research conducted in 2012, showed that about 3.7 billionpeople aged below 50 years (approximately 67% of ...
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Using offender regulation for you to police and punish erotic conduct has become going up before 12 months, with a number of high-profile times when HIV-positive men and women encountered costs depending on accusations involving coverage without disclosure charged with having most likely dangerous sexual intercourse with others without having unveiling their own Aids status. HSV2, alternatively, mainly arises from obtaining sexual intercourse having an infected particular person. Genital Herpes: Which are the Information? This is known as getting rid of since these new malware can easily, at the moment, rub off about someone else. Find out about herpes simplex virus transmission and if you will get hsv simplex virus from the bathroom. HIV, the herpes simplex virus that causes AIDS, can distributed if the contaminated person shares needles, or if polluted blood emerged in a body transfusion. The answer to your current real question is no!. Do we actually require a safeguard to start with? Whats ...
Either herpes simplex virus type 1 (HSV-1) or herpes simplex virus type 2 (HSV-2) can cause infection. HSV-1 is the most common cause of lesions that appear around the mouth and on the lips. HSV-2 is the typical cause of genital herpes. Both conditions are highly contagious and are spread by direct contact with the lesions of another infected individual such as a playmate, parent, or caretaker. The virus can even spread in the absence of symptoms or visible lesions ...
Herpes or Herpes simplex is a viral disease caused by the Herpes Simplex Virus and Herpes Simplex Treatment is quite an important topic. It is chronic and a dangerous skin infection which usually affects face, mouth and the genitals. Herpes Simplex has been so dangerous as well as common today that it has been termed as the most common Sexually Disease (STD) by the number of cases. A large part of the human population is suffering from Herpes Simplex in todays scenario. As many as 50 million people are suffering from Herpes Simplex in the USA alone. It makes a sum total of 20% of the total American males and over 25% females. This has made it quite necessary to find some effective Herpes Simplex Treatments which can easily and efficiently cure Herpes. Herpes is caused by the Herpes Simplex Virus, which is of two types, namely HSV-1 and HSV-2. Similarly, Herpes is also broadly categorized into two main categories, Oral Herpes and Genital Herpes. The type of Herpes Simplex which affects the face ...
Herpes simplex virus (HSV) is an infection very common worldwide that causes herpes. It is categorized into two types: herpes simplex virus type 1 (HSV-1, oral herpes) and herpes simplex virus type 2 (HSV-2, genital herpes). Herpes simplex virus type 1 is a cause of cold sores and fever blisters on the mouth and lips, and can be transmitted...
Herpes Simplex Virus Type 1 Herpes simplex virus type 1 is one of the two types of herpes simplex viruses; it may also be called HSV-1. This virus is more common than its counterpart and is the culprit for oral sores or cold sores. Herpes simplex virus type 1 may also cause genital herpes but […]. ...
Herpes Simplex Cure has gotten to be a standout among the most widely recognized themes in the entire universe of well-being and solutions and is getting more prevalent step by step as the quantity of instances of Herpes is on the climb and more individuals have begun searching for viable Herpes Cure 9. As per a well-being concentrate, more than 50 million individuals all around the globe are experiencing Herpes today. A general well-being study even says that more than 20% of the guys and more than 25% females in the USA are experiencing Herpes, among which 85% of the cases are of the Genital Herpes alone. This has even expanded the need to locate a powerful Herpes Simplex Cure. There are numerous sorts of Herpes Simplex Cures accessible today in the entire field of well-being and medications. In any case, to know and comprehend the viable Herpes Simplex Cure, one must think about what Herpes really is. Herpes Simplex, all the more generally known as Herpes, is a viral ailment in which the ...
Gene US9 of herpes simplex virus type 1 has been predicted, from DNA sequence analysis, to encode a protein of mol wt 10,026, designated 10K (D. J. McGeoch, A. Dolan, S. Donald, and F. J. Rixon (1985). J. Mol. Biol. 181,1-13). We have investigated this protein by using a synthetic peptide corresponding to the 11 amino acids adjacent to the amino-terminal methionine and rasing antisera in rabbits. One antiserum was able to precipitate at least 12 electrophoretically distinct polypeptide species from extracts of BHK cells infected with HSV-1. The estimated molecular weights of these polypeptides ranged from 12K to 20K and immunoblotting showed them to be related proteins. The primary translation product has an apparent mol wt of 13K. The various forms of 10K differ in their relative abundance in the infected cell and also in their degree of phosphorylation. Lower molecular weight forms of the 10K protein can be precipitated from NP-40 extracts of HSV-1 virions, suggesting that these forms of 10K ...
Disseminated herpes simplex virus infection during pregnancy is uncommon but is accompanied by high maternal and fetal morbidity and mortality. Pregnant women with primary mucous membrane infection during the third trimester may run an increased risk for dissemination, although specific predisposing factors are unknown. Diagnosis requires awareness of the clinical syndrome, a high index of suspicion in the proper setting, and appropriate use of available diagnostic techniques. Although the disease may be self-limited, mortality approaches 40% for mother and fetus. In the presence of severe or progressive systemic infection, specific antiviral chemotherapy with vidarabine may be warranted. Management of the fetus remains problematic; prompt delivery by cesarean section may be indicated.
herpes simplex virus type 2 ICP10 protein: multifunctional protein with ribonucleotide reductase and serine/threonine protein kinase domains
A seroepidemiologic study of herpes simplex virus type 1 HSV-1 and 2 HSV-2 was performed on Japanese adults. Serum samples collected between 1985-9 from a total of 536 healthy adults, female prostitutes, males with sexually transmitted diseases STD, homosexual men, and pregnant women were studied by immunodot assays using HSV type-specific...
TY - JOUR. T1 - Primary and recurrent concomitant genital infection with herpes simplex virus types 1 and 2. AU - Fife, Kenneth H.. AU - Schmidt, Ortwin. AU - Remington, Michael. AU - Corey, Lawrence. PY - 1983/1/1. Y1 - 1983/1/1. UR - http://www.scopus.com/inward/record.url?scp=0020659842&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020659842&partnerID=8YFLogxK. U2 - 10.1093/infdis/147.1.163. DO - 10.1093/infdis/147.1.163. M3 - Article. C2 - 6296239. AN - SCOPUS:0020659842. VL - 147. SP - 163. JO - Journal of Infectious Diseases. JF - Journal of Infectious Diseases. SN - 0022-1899. IS - 1. ER - ...
Herpes simplex virus type 1 (HSV-1) is the most common pathogenic cause of sporadic acute encephalitis and it produces latent persistent infection lifelong in infected individuals. Brain inflammation
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BioAssay record AID 110716 submitted by ChEMBL: Average survival rate of mice infected intravaginally with herpes simplex virus type 2 at daily dosage of 2.5%(treatment initiated 4-h postinfection and continued for 7 days).
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Inhibition of proteoglycan synthesis in human endothelial cells after infection with herpes simplex virus type 1 in vitro. Academic Article ...
Cherpes, T.L., Meyne, L.A., Krohn, M.A., et al. (2003) Risk factors for infection with herpes simplex virus type 2 Role of smoking, douching, uncircumcised males, and vaginal flora. Sexually Transmitted Diseases, 30, 405-410. doi10.1097/00007435-200305000-00006
The controlled evaluation of vidarabine as therapy of neonatal herpes simplex virus (HSV) infection provided an opportunity to collect data to further assess the natural history of maternal and newborn infections. Women delivering infected babies were young, nulliparous, and infrequent aborters. Nearly 50% of the gestations ended in premature labor. Maternal infection was asymptomatic in 39 of 56 (70%) of the mothers, at the time of delivery. However, risk factors included a past history of genital herpes at any time and exposure to a sexual partner with presumed HSV lesions. Associated diseases in children born to these women were common. Premature infants had an incidence of respiratory distress of 52% (14 of 27). Eight of 29 (28%) term newborns had a bacterial infection, antedating the onset of neonatal HSV infection. Virologic studies on infected newborns confirmed that skin lesions were the most frequent site for virus retrieval. Progression of disease from isolated skin lesions was common, ...
Virus Herpes Simplex Virus 1 ELISA Kit (Colorimetric). High sensitivity ELISA kit for detection of Herpes Simplex Virus 1. Backed by our 100% Guarantee.
Weve over several weeks previously experienced sex, nevertheless think now, commence getting herpes virus due to the fact my vaginal area has been extremely agitated as well as crimson and possibly a little enlarged. We have herpes virus simplex for the mouth area hectic given that he has been 18 years. Genuine story: I have herpes virus And also untrue negative blood analyze hsv simplex virus as well as culture are incredibly, very common. Can easily an episode to another, more a few months. How do males and females of herpes for you to capture signs, and just what they can perform. He previously consumed your way of life with the taste, but the medical doctor explained he alleged that herpes simplex virus. I spotted which i caught a year ago for together with recurrent breakouts within a period of A couple of years in the same place than Its about time an insect bite. I havent had an outbreak of age range and today only obtain the prickling it doesnt arrived at something have to try not to ...
Genital Herpes Symptoms. Learn about genital herpes symptoms, genital herpes treatment options, and how to manage your herpes simplex outbreaks. Signs of herpes tend to develop within 3-7 days of skin-to-skin contact with an infected person. Valuable informations about Herpes Simplex Virus Symptoms at Genital | Herpes | Facts
The Herpes Viruses. The herpes simplex virus (HSV) causes herpes. There are two types of herpes viruses - the herpes simplex virus 1 (HSV-1) and the herpes simplex virus 2 (HSV-2).. They usually infect the skin and the mucous membranes, but its not at all uncommon for them to also attack the other parts of the body. Herpes is believed to be one of the most difficult conditions to deal with, and has been plaguing mankind for a very, very long time.. While the viruses we mentioned above are the two most common herpes viruses causing herpes, there are actually many more of them that result in different medial conditions. In fact, its believed that there are as many as 80 more different types of herpes viruses, and they all have something different about them, though they also share some common characteristics.. Coming to the meaning of the term herpes, its a Greek word that means to creep. The reason the herpes viruses have been given this name is because of a common characteristic they ...
The paper is published in the Journal of Immunology. Lead investigator, Associate Professor Cheryl Jones said HSV was a medically-significant virus that caused devastating disease throughout life for sufferers.. Herpes simplex virus is the virus that causes cold sore, genital herpes, serious brain disease and newborn infections, she said.. The skin represents a major entry point; therefore understanding how immune cells behave during the infection is of vital importance to researchers trying to find a cure for HSV.. HSV infection of the skin and genital mucosa are important for the promotion and transmission of HIV, the virus that causes AIDS.. Associate Professor Jones said the research was the result of a joint collaboration between the Sydney Medical School, Kids Research Institute at Childrens Hospital at Westmead, the Centenary Institute and the Westmead Millennium Institute.. We used fluorescent viruses and mice in which immune cells were tagged with green fluorescent protein to ...
"Herpes simplex virus". World Health Organization. 31 January 2017. "EVERYTHING YOU NEED TO KNOW ABOUT HERPES". 2017-12-11. ... Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA (January 1997). "Herpes simplex virus type 1 in brain and risk ... Dobson CB, Itzhaki RF (1999). "Herpes simplex virus type 1 and Alzheimer's disease". Neurobiol. Aging. 20 (4): 457-65. doi: ... Human alphaherpesvirus 1 (HHV-1) is a species of virus in the genus Simplexvirus, subfamily Alphaherpesvirinae, family ...
Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB ... Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion ... Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion ... A Herpes Simplex Virus Recombinant That Exhibits a Single-Chain Antibody to HER2/neu Enters Cells through the Mammary Tumor ...
Viruses: Herpes simplex virus. Fungi: Candida spp. Fusarium Parasites: Toxoplasma gondii, Toxocara. Late-onset endophthalmitis ...
"Herpes Simplex Virus (HSV) Infections". MSD Manuals. Retrieved 27 November 2018. L Wiler, Jennifer (September 2006). "Diagnosis ... "Herpes Simplex Virus" (PDF). Retrieved 27 November 2018. Aslanova, Minira; Zito, Patrick M. (27 October 2018). Herpetic ... George AK, Anil S (June 2014). "Acute herpetic gingivostomatitis associated with herpes simplex virus 2: report of a case". ... Kolokotronis A, Doumas S (March 2006). "Herpes simplex virus infection, with particular reference to the progression and ...
An example would include the ability of the herpes simplex virus, which causes cold sores, to remain in a dormant state within ... Talimogene laherparepvec (T-VEC), for example, is a modified herpes simplex virus that has had a gene, which is required for ... Examples of nucleoside analogues are aciclovir for Herpes simplex virus infections and lamivudine for HIV and hepatitis B virus ... Whitley RJ, Roizman B (May 2001). "Herpes simplex virus infections". Lancet. 357 (9267): 1513-18. doi:10.1016/S0140-6736(00) ...
"Herpes simplex virus Research". Archived from the original on December 12, 2012. Retrieved Oct 25, 2007. Lee HR, Kim DJ, Lee JM ... Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL (2004). "The herpes simplex virus ICP0 RING finger domain inhibits IRF3- ... ICP0 was identified as an immediate-early polypeptide product of Herpes simplex virus-1 (HSV-1) infection in 1976. The gene, in ... Perry LJ, Rixon FJ, Everett RD, Frame MC, McGeoch DJ (November 1986). "Characterization of the IE110 gene of herpes simplex virus ...
Lewis, ML; Culbertson, WW; Post, JD; Miller, D; Kokame, GT; Dix, RD (1989). "Herpes simplex virus type 1. A cause of the acute ...
Herpetic infection (herpes simplex virus). Fissured tongue. Lichen planus. Allergies and contact sensitivities to foods, metals ...
As of 2012, an estimated 3.7 billion people globally were infected with oral herpes simplex virus (HSV-1), and 417 million were ... Upon initial infection, herpes simplex virus (HSV) causes acute lytic infection of epithelial cells, usually at either genital ... Sawtell NM, Triezenberg SJ, Thompson RL (December 2011). "VP16 serine 375 is a critical determinant of herpes simplex virus ... Knipe DM, Cliffe A (March 2008). "Chromatin control of herpes simplex virus lytic and latent infection". Nature Reviews. ...
... is an infection by the herpes simplex virus (HSV) of the genitals. Most people either have no or mild symptoms ... Genital Herpes simplex virus (HSV) Infections. from the Public Health Agency of Canada. Date Modified: 2013-02-01. "Brand Name ...
"Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ... In this case the study uses the transfer of the Herpes simplex virus type I thymidine kinase (HSVtk) as the cytotoxic gene. ... "PaxVax Signs R&D Collaboration with UC San Diego to Develop a Vaccine to Prevent Herpes Simplex Virus Infections". paxvax.com. ... Mesnil M, Piccoli C, Tiraby G, Willecke K, Yamasaki H (March 1996). "Bystander killing of cancer cells by herpes simplex virus ...
White CA, Stow ND, Patel AH, Hughes M, Preston VG (June 2003). "Herpes Simplex Virus Type 1 Portal Protein UL6 Interacts with ... Newcomb WW, Homa FL, Brown JC (August 2005). "Involvement of the portal at an early step in herpes simplex virus capsid ... Article: [2]) Singer GP, Newcomb WW, Thomsen DR, Homa FL, Brown JC (2005). "Identification of a region in the herpes simplex virus ... Newcomb WW, Thomsen DR, Homa FL, Brown JC (September 2003). "Assembly of the herpes simplex virus capsid: identification of ...
Herpes simplex virus is divided into two types. However, each may cause infections in all areas. HSV-1 causes primarily mouth, ... Herpes simplex virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be ... Kim H, Meier A, Huang M, Kuntz S, Selke S, Celum C, Corey L, Wald A (2006). "Oral herpes simplex virus type 2 reactivation in ... There are two types of herpes simplex virus, type 1 (HSV-1) and type 2 (HSV-2). HSV-1 more commonly causes infections around ...
The herpes simplex virus protein ICP34.5 also activates protein phosphatase 1, which overcomes the cellular stress response to ... Agarwalla PK, Aghi MK (2012). "Oncolytic herpes simplex virus engineering and preparation". Oncolytic Viruses. Methods in ...
acyclovir (Zovirax), for herpes simplex virus infection. 1996 Stanley Norman Cohen (Co-recipient, Lemelson-MIT Prize) for the ...
Corey L (March 1986). "Laboratory diagnosis of herpes simplex virus infections. Principles guiding the development of rapid ...
Herpes simplex virus (Herpesviridae family) - anterograde Pseudorabies virus PRV (Herpesviridae family) - retrograde trans- ... "Herpes simplex virus as a transneuronal tracer. [Review]". Neurosci Biobehav Rev. 22 (6): 695-708. doi:10.1016/s0149-7634(98) ... "Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP". J Neurosci Methods. ...
Herpes virus include chicken-pox virus and herpes simplex viruses (HSV-1, HSV-2), all of which establish episomal latency in ... An example of such a gene product is the latency associated transcripts (LAT) in herpes simplex virus, which interfere with ... In the case of herpes simplex virus, which generally infects an individual for life, a serotype of the virus reactivates ... Burton EA, Fink DJ, Glorioso JC (Dec 2002). "Gene delivery using herpes simplex virus vectors". DNA Cell Biol. 21 (12): 915-36 ...
Chilukuri, S; Rosen, T (Apr 2003). "Management of acyclovir-resistant herpes simplex virus". Dermatologic Clinics. 21 (2): 311- ...
The herpes simplex virus affects the frontal and temporal lobes, subcortical structures, and the hippocampal tissue, which can ... Naudé H, Pretorius E (3 Jun 2010). "Can herpes simplex virus encephalitis cause aphasia?". Early Child Development and Care. ...
Viral nonstructural protein Agarwalla PK, Aghi MK (2012). "Oncolytic herpes simplex virus engineering and preparation". Methods ... February 2003). "ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties ... ɣ34.5 gene in viruses such as herpes simplex virus; it blocks a cellular stress response to viral infection. It shares the C- ...
... is taken up by normal cells and cancer cells like the wild type herpes simplex virus, it is cleared in ... Agarwalla PK, Aghi MK (2012). "Oncolytic herpes simplex virus engineering and preparation". Oncolytic Viruses. Methods in ... February 2003). "ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties ... it is an oncolytic herpes virus that was created by genetically engineering a strain of herpes simplex virus 1 (HSV-1) taken ...
Herpes simplexvirus. 150 Kb. DNA vector, episomal, lasting expression, immunogenic Bacterial vector species (bacterial ...
Herpes simplex virus can cause multiple mouth ulcers. Measles Common cold: rhinovirus, coronavirus, respiratory syncytial virus ...
Jabs DA (1998). "Acyclovir for recurrent herpes simplex virus ocular disease". N Engl J Med. 339 (5): 340-341. doi:10.1056/ ...
... or the viruses herpes simplex virus and adenovirus. Investigations such as a gram stain of the discharge might reveal the cause ...
It has shown effectiveness against herpes simplex virus. Mercuration of the 2'-deoxyuridine 1 leads to the organometallic ... "Topical antiviral agents for herpes simplex virus infections". Drugs of Today. 34 (12): 1013-25. doi:10.1358/dot.1998.34. ...
The cause is usually herpes simplex virus type 1 (HSV-1) and occasionally herpes simplex virus type 2 (HSV-2). The infection is ... "Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14-49: United States, 2015-2016". www.cdc.gov. July 2, ... Infection by the type 1 strain of herpes simplex virus (HSV-1) is most common; however, cases of oral infection by the type 2 ... Herpes labialis, commonly known as cold sores, is a type of infection by the herpes simplex virus that affects primarily the ...
The incidence of Herpes simplex virus meningitis is estimated to be 0.2-5.0 cases per 10,000 live births. Neonatal meningitis ... In cases of meningitis caused by Herpes simplex virus, antiviral therapy with (acyclovir or vidarabine) must be started ... Kimberlin, D. (2004). Herpes simplex virus, meningitis and encephalitis in neonates. breast, 20, 22. Puopolo, Karen M; Baker, ...
A herpetic whitlow is a lesion (whitlow) on a finger or thumb caused by the herpes simplex virus. It is a painful infection ... Lewis MA (2004). "Herpes simplex virus: an occupational hazard in dentistry". Int Dent J. 54 (2): 103-11. doi:10.1111/j.1875- ... Alster, T. S.; Nanni, C. A. (March 1999). "Famciclovir prophylaxis of herpes simplex virus reactivation after laser skin ...
Herpes simplex virus (HSV) is a lifelong virus that is categorized into two distinct herpesvirus species, herpes simplex virus ... Herpes simplex virus (HSV) in infants can be severe. Mothers with HSV can continue to breastfeed if no lesions are present on ... 1 (HSV-1) and herpes simplex virus 2 (HSV-2). HSV-1 is typically transmitted by oral-oral contact to cause oral herpes but can ...
Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae ... CS1 maint: discouraged parameter (link) Viralzone: Simplexvirus ICTV. ... 3 Papiine alphaherpesvirus 2 Pteropodid alphaherpesvirus 1 Saimiriine alphaherpesvirus 1 Viruses in Simplexvirus are enveloped ...
I think that doing it in the suggested way would be whats best for all concerned, but I dont know if the Herpes simplex virus ... and include in it a disambiguation link to Herpes simplex virus protein vmw65. Right now, VP16 is a disambiguation link to this ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Talk:Herpes_simplex_virus_protein_vmw65&oldid=598549158" ...
... Updated: Mar 01, 2018 * Author: Folusakin O Ayoade, MD; Chief Editor: Michael ... Transmission of herpes simplex virus types 1 and 2 in a prospective cohort of HIV-negative gay men: the health in men study. J ... Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med. 1997 Oct 16. 337(16):1105-11. [Medline]. ... Herpes simplex virus infections of the central nervous system. A review. Am J Med. 1988 Aug 29. 85(2A):61-7. [Medline]. ...
Genital Herpes , herpes simplex virus 2 cure. Author: admin, 08.03.2015. Category: Herpes Simplex Virus ... Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in ... Herpes Simplex Virus 2 (HSV2)mainly gives rise to genital herpes, the most common type of sexually transmitted infection (STI ... Sun Y, Yang J. Experimental study of Astragalus membranaceus against herpes simplex virus type 1. 2004 Jan;24(1):57-8.. ...
"Herpes simplex virus". World Health Organization. 31 January 2017. "Prevalence of Herpes Simplex Virus Type 1 and 2" (PDF). CDC ... Herpes simplex virus is likely the most common cause of Mollarets meningitis. In worst-case scenarios, it can lead to a ... Herpes simplex viruses can affect areas of skin exposed to contact with an infected person (although shaking hands with an ... Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human alphaherpesvirus 1 and Human ...
Drugs & Diseases , Ophthalmology , Herpes Simplex Virus (HSV) Keratitis Q&A How is herpes simplex virus (HSV) endotheliitis ... Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ... Herpes Simplex Virus Disease of the Anterior Segment in Children. Cornea. 2015 Oct. 34 Suppl 10:S68-71. [Medline]. ... New-onset herpes simplex virus keratitis after cataract surgery. Cornea. 2009 Jan. 28(1):108-10. [Medline]. ...
HERPES SIMPLEX VIRUS TYPE 2-GLYCOPROTEIN G PROTEINS AND POLYPEPTIDES. WO1992002251A1. 1992-02-20. HERPES SIMPLEX VIRUS VP16 ... A method for distinguishing between herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) in a human ... These infections are caused by two viruses, herpes simplex virus type 1 ("HSV-1") and herpes simplex virus type 2 ("HSV-2"). ... Herpes simplex virus ("HSV") infections are extremely prevalent and have a range of manifestations from apparently asymptomatic ...
What is HSV (Herpes Simplex Virus) keratitis?. HSV (Herpes Simplex Virus) keratitis is an infection of the cornea-the clear ... Ocular herpes simplex virus type 1: is the cornea a reservoir for viral latency or a fast pit stop?external icon Cornea. 2011; ... Seroprevalence of Herpes Simplex Virus Types 1 and 2-United States, 1999-2010external icon. J Infect Dis. 2013. ... Recurrence rates of herpes simplex virus keratitis in contact lens and non-contact lens wearersexternal icon. Eye Contact Lens ...
Herpes simplex viruses are categorized into two types: type 1 (HSV-1 or oral herpes) and type 2 (HSV-2 or genital herpes). Most ...
... Lancet. 2001 May 12;357(9267):1513-8. doi: 10.1016/S0140-6736(00)04638-9. ... Herpes simplex virus (HSV) is a member of the herpesviridae family. Recognised since ancient Greek times, the virus frequently ...
... "herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2)." While HSV-1 causes facial ulcers, HSV-2 causes ... The Herpes Simplex Virus (HSV) is a "ubiquitous human pathogen that belongs to the Herpesviridae".[1] The two common variants ... Struyf, Frank (1 September 2004). Genetic Analysis of Herpesvirus Entry Receptors and Host Susceptibility to Herpes Simplex Virus ... Herpes Simplex Virus (HSV) is a member of the Herpesviridae family of viruses, a family of DNA viruses important in human ...
p,【要旨】単純ヘルペスウイルス1型(herpes simplex virus-1、以下 HSV-1)によって引き起こされる疾患は 一般的に良性感染症といえるものの、造血幹細胞移植患者や原発性免疫不全患者では、HSV-1 は重篤で、かつ、慢性に経過する重 ... ヘルペス亜科に分類される単純ヘルペスウイルス1型 (herpes simplex virus type 1: HSV-1), 2型 (HSV-2), 水痘・帯状疱疹ウイルス (varicella-zoster virus: VZV) 感染症は皮膚科, 耳 ... A case of herpes simplex virus encephalitis recurring after
Oncolytic herpes simplex virus type 1 (HSV-1) vectors are emerging as an effective and powerful therapeutic approach for cancer ... Oncolytic herpes simplex virus vectors for cancer virotherapy.. Varghese S1, Rabkin SD. ...
Glutamine supplementation suppresses herpes simplex virus reactivation. Kening Wang,1 Yo Hoshino,1 Kennichi Dowdell,1 Marta ... Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. ... Role of IFN-gamma and tumor necrosis factor-alpha in herpes simplex virus type 1 infection. J Interferon Cytokine Res. 2002;22( ... CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J Exp Med. 2000;191( ...
One of the most common sexually transmitted infections is the herpes simplex virus (HSV) Type 2. Although the incidence of ...
Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite ...
Herpes Simplex Virus 2 News and Research. RSS Herpes Simplex Virus-2 is a sexually transmitted viral infection, which often ... Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus ... the findings show that fewer of todays teens have been exposed in their childhood to herpes simplex virus type 1 (HSV-1), a ...
Herpes Simplex Virus May Up Risk of Alzheimers. By Traci Pedersen Associate News Editor ... A person who carries certain antibodies of the herpes simplex virus may be at double the risk for Alzheimers disease, ... Pedersen, T. (2018). Herpes Simplex Virus May Up Risk of Alzheimers. Psych Central. Retrieved on September 20, 2020, from ... Home » News » Herpes Simplex Virus May Up Risk of Alzheimers. .fn { margin:-2px 0 0 0;font-size:90%!important; } .time-read { ...
encoded search term (Herpes Simplex Virus Empiric Therapy) and Herpes Simplex Virus Empiric Therapy What to Read Next on ... Herpes Simplex Virus Empiric Therapy Updated: May 31, 2016 * Author: Amy Margaret Lazarides, MD, FACEP; Chief Editor: Michael ... Severe herpes simplex virus disease. Disseminated HSV disease or severe symptoms in the immunocompromised patient [1] : ... See Herpes Simplex Viruses: Test Your Knowledge, a Critical Images slideshow, for more information on clinical, histologic, and ...
Herpes Simplex Virus 2 News and Research. RSS Herpes Simplex Virus-2 is a sexually transmitted viral infection, which often ... Women who are infected with herpes simplex virus type 2 (HSV-2) may have an increased risk of transmitting the virus to others ... Female sex hormones have a profound effect on susceptibility to the herpes simplex virus Two McMaster University studies, to be ... New gene therapy treatment involves injecting Herpes simplex virus into the brain tumours of Glioma patients Experts on the ...
... Bryan Kiehl b3748 at cts.com Fri Dec 13 13:35:18 EST 1996 *Previous message: ...
It is a viral infection caused by Herpes Simplex Virus Type 1 (HSV-1). Once you get infected by the virus, it will stay ... I will reveal what causes cold sores in most sufferers.The root of what causes cold sores in everyone is the herpes simplex virus ...
... *Human immunodeficiency virus infection *Human papillomavirus infection *Chancroid * ... Two types of herpes simplex virus (HSV) have been distinguished based on immunological as well as clinical differences. Type 1 ... Figure 59-3. First-episode primary genital herpes simplex virus infection. (From Wendel and Cunningham, 1991.) ...
NAME: Herpes simplex virus (HSV) SYNONYM OR CROSS REFERENCE: Herpesvirus type 1 (fever blister, cold sore), Herpesvirus type 2 ... CHARACTERISTICS: Herpesviridae, Alphavirinae, genus Simplexvirus; double-stranded linear DNA virus, icosahedral, lipid envelope ...
More than 50% of the U.S. population is infected with herpes simplex virus type-I (HSV-1) and global infectious estimates are ... Autophagy interaction with herpes simplex virus type-1 infection.. OConnell D1, Liang C1. ...
Herpes simplex virus latency-associated transcript is a stable intron. M J Farrell, A T Dobson, and L T Feldman ... Herpes simplex virus latency-associated transcript is a stable intron Message Subject (Your Name) has sent you a message from ... a herpes simplex virus type 1 immediate-early gene that encodes a transactivating protein that may facilitate re-activation of ... viral transcript detected by in situ hybridization of mouse and human sensory ganglia latently infected with herpes simplex virus ...
... Jay C. Brown. Department of Microbiology, Immunology, and Cancer ... L. A. Waggoner-Fountain and L. B. Grossman, "Herpes Simplex Virus," Pediatrics in Review, vol. 25, no. 3, pp. 86-93, 2004. View ... Herpes simplex virus (HSV1) resembles other herpesviruses in its ability to cause both lytic and latent infections [1, 5]. ... K. N. Mohni, C. M. Livingston, D. Cortez, and S. K. Weller, "ATR and ATRIP are recruited to herpes simplex virus type 1 ...
... Jay C. Brown Department of Microbiology, Immunology, and Cancer ... Like all herpesviruses, herpes simplex virus 1 (HSV1) is able to produce lytic or latent infections depending on the host cell ...
Herpes simplex virus (HSV) is a double-stranded, enveloped, DNA virus. Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) ... Neonatal herpes simplex virus disease is associated with high morbidity and mortality. [19] Herpes simplex virus infections are ... 31, 40] Of mothers who deliver an infant with herpes simplex virus infection, 60-80% have no evidence of genital herpes simplex ... At the time of vaginal delivery, the risk of herpes simplex virus transmission from a mother with true primary herpes simplex ...
  • Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. (wikipedia.org)
  • Currently, 13 species are placed in this genus: Ateline alphaherpesvirus 1 Bovine alphaherpesvirus 2 Cercopithecine alphaherpesvirus 2 Human alphaherpesvirus 1 Human alphaherpesvirus 2 Leporid alphaherpesvirus 4 Macacine alphaherpesvirus 1 Macropodid alphaherpesvirus 1 Macropodid alphaherpesvirus 2 Panine alphaherpesvirus 3 Papiine alphaherpesvirus 2 Pteropodid alphaherpesvirus 1 Saimiriine alphaherpesvirus 1 Viruses in Simplexvirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. (wikipedia.org)