Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
Gene Expression Regulation, Bacterial
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Product Line Management
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
In the rhizosphere, chemotaxis is used by the host - the plant - to mediate the motility of the soil which allows for microbial ... Phycosphere bacterial diversity in green algae reveals an apparent similarity across habitats. Algal Research, 8, 140-144. doi ... In terms of community construction, chemotaxis is used in both environments in order to propagate the recruitment of microbes. ... 10.1016/j.algal.2015.02.003 9. Scharf, B. E., Hynes, M. F., & Alexandre, G. M. (2016). Chemotaxis signaling systems in model ...
... with the twitching motility system have strong sequence and structural similarity to those that regulate bacterial chemotaxis ... In contrast to the run-and-tumble model of chemotaxis associated with flagellated cells however, movement towards ... Oliveira, Nuno M.; Foster, Kevin R.; Durham, William M. (2016-06-07). "Single-cell twitching chemotaxis in developing biofilms ... Sampedro, Inmaculada; Parales, Rebecca E.; Krell, Tino; Hill, Jane E. (January 2015). "Pseudomonas chemotaxis". FEMS ...
Marc A. Suchard
Evolutionary similarity among genes, Journal of the American Statistical Association 98:653-662, 2003. D'Orsogna MR, Suchard MA ... and Chou T. Interplay of chemotaxis and chemokinesis mechanisms in bacterial dynamics, Physical Review E 68, 021925, 2003. ...
An increase in chemotaxis can be related to malignant migration of cancer cells. Investigation into the anti-tumor properties ... Despite this similarity in function during differentiation, DIFs -1 and -2 act very differently in chemotactic movement of the ... Some research has shown that they have a role in controlling chemotaxis of Dictyostelium discoideum, too. DIF-1 and DIF-3 are ... 2 Function also as Modulators for Dictyostelium Chemotaxis". PLoS ONE. 4 (8): e6658. Bibcode:2009PLoSO...4.6658K. doi:10.1371/ ...
CXC chemokine receptors
ACKR3 was originally called RDC-1 (an orphan receptor) but has since been shown to cause chemotaxis in T lymphocytes in ... and its similarity to other chemokine receptors in its gene sequence. CXCR6 binds the ligand CXCL16. However, CXCR6 is more ...
By sequence similarity, most sigma factors are σ70-like (InterPro: IPR000943). They have four main regions (domains) that are ... the flagellar synthesis and chemotaxis sigma factor σ32 (RpoH) - the heat shock sigma factor, it is turned on when the bacteria ...
... regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar ... It shares 76% nucleic acid identity and 83% amino acid similarity to the equivalent molecule in mouse. Sequence analysis has ...
Formyl peptide receptor 1
Two receptors where thereafter discovered and named FPR2 and FPR3 based on the similarity of their genes' predicted amino acid ... and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20)". Journal of Immunology. 172 (12): 7734-43. doi: ... "Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway ... by an apparent receptor-dependent mechanism to migrate in a directional pattern in classical laboratory assays of chemotaxis. ...
Formyl peptide receptor
Chemotaxis Receptors Migeotte I, Communi D, Parmentier M (Dec 2006). "Formyl peptide receptors: a promiscuous subfamily of G ... Two receptors where thereafter discovered and named FPR1 and FPR2 based on the similarity of their genes' predicted amino acid ... The formyl peptide receptors (FPR) belong to a class of G protein-coupled receptors involved in chemotaxis. In humans, there ... The close phylogenetic relation of signaling in chemotaxis and olfaction was recently proved by detection formyl peptide ...
John I. Gallin
ISBN 978-0-88-167160-5 Gallin, J. I. and Quie, P. G. "Leukocyte Chemotaxis: Methods, Physiology and Clinical Implications." New ... "Cloning of a 67K neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src". Science. 248 (4956): 727-730 ... microtubule and microfilament orientation and function during chemotaxis". Journal of Cell Biology. 75 (3): 666-693. doi: ...
P2Y family has 8 receptors that can be divided into two sub-families depending upon the structural similarity. P2X receptors ... chemotaxis, the release of mediators, cell maturation, cytotoxicity, and cell death etc. Depending on the nature of the ...
... endothelial cell chemotaxis, immune cell trafficking and mitogenesis. Sphingosine-1-phosphate receptors are also involved in ... "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to ...
... based on its amino acid sequence similarity to the known FMLP receptor, FPR1. At least six homologues of this receptor are ... LXA4 and 15-epi-LXA4 inhibit chemotaxis, transmigration, superoxide generation, NF-κB activation, and/or generation of pro- ...
Subsequently, Formyl peptide receptor 2 and Formyl peptide receptor 3 were also cloned based on the similarities in their amino ... I. Cite uses generic title (help) Harris H (Jul 1954). "Role of chemotaxis in inflammation". Physiological Reviews. 34 (3): 529 ... fMLF proved the most potent in stimulating rabbit neutrophil chemotaxis. fMLF and a sampling of other, less potent, N-formyl ... Leukocyte chemotaxis: Methodology, physiology, clinical implications. New York.: Raven Press.CS1 maint: multiple names: authors ...
The similarities between archaella and T4P became more obvious with the identification of two archaella motor complex proteins ... The genes coding for arlC, arlD, and arlE are only present in Euryarchaeota and interact with chemotaxis proteins (e.g., CheY, ... Faguy DM, Jarrell KF, Kuzio J, Kalmokoff ML (January 1994). "Molecular analysis of archael flagellins: similarity to the type ... March 2009). "Identification of Archaea-specific chemotaxis proteins which interact with the flagellar apparatus". BMC ...
This strain has an extra 244 genes which are believed to aid the bacterium in chemotaxis and in the formation of both a pilus ... Two strains of P. stutzeri can be classified in a single genomovar if DNA-DNA similarity is at least 70% similar. Seven ... The inclusion of this bacterium into the Pseudomonas genus was confirmed by DNA-DNA hybridization and similarity comparisons of ...
N. gargensis is observed in small abnormal cocci groupings and uses its archaella to move via chemotaxis. Being an Archaeon, ... elucidated, in 2012, the notable similarities between N. gargensis and N. viennensis through their nitrification ability and ... and it utilizes flagella to move via chemotaxis. The membrane composition of ammonia-oxidizing archaea, specifically through a ...
Lux R, Shi W (July 2004). "Chemotaxis-guided movements in bacteria". Critical Reviews in Oral Biology and Medicine. 15 (4): 207 ... Classification seeks to describe the diversity of bacterial species by naming and grouping organisms based on similarities. ... Motile bacteria are attracted or repelled by certain stimuli in behaviours called taxes: these include chemotaxis, phototaxis, ...
Steroid hormone receptor
Since eggs release progesterone, sperm may use progesterone as a homing signal to swim toward eggs (chemotaxis). Sex hormone- ... the similarities between the steroid hormones and between the receptors make plausible the argument that each receptor may ...
Finally, H4 plays roles in mast cell chemotaxis and cytokine production. In humans, HDC is primarily expressed in mast cells ... The enzyme employs a pyridoxal 5'-phosphate (PLP) cofactor, in similarity to many amino acid decarboxylases. Eukaryotes, as ...
In one experiment, the addition of PPIB into cell cultures in vitro induced chemotaxis and integrin-mediated adhesion of T ... the families have no sequence of structural similarities. As a cyclophilin, PPIB binds cyclosporin A (CsA) and can be found ...
Formyl peptide receptor 2
They stimulate granulocytes to migrate directionally (see chemotaxis) and become active in engulfing (see phagocytosis) and ... FPR2 and FPR3 are termed formyl peptide receptors base on the similarities of their amino acid sequences to that of FPR1 rather ... and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20)". Journal of Immunology. 172 (12): 7734-43. doi: ...
Two-component regulatory system
Because of their sequence similarity and operon structure, many two-component systems - particularly histidine kinases - are ... which plays a central role in the chemotaxis system. Histidine kinases usually have an N-terminal ligand-binding domain and a C ... "Identification of the site of phosphorylation of the chemotaxis response regulator protein, CheY". The Journal of Biological ...
This chemotaxis system encodes for at least 15 proteins. Collingro et al. believe this system to be functional, as they found ... It had a sequence similarity of 70 to 75% when compared to bacteria from other phyla in the same domain. From this information ... Further analysis of the genome of P. acanthamoebae shows that this bacterium has genes that encode a chemotaxis system that is ... The specific role of this chemotaxis system in P. acanthamoebae is unclear, however, since this bacterium is non-motile. ...
Filopodin, a slime mould protein that binds actin and which is involved in the control of cell motility and chemotaxis. Merlin ... but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. ERM ...
... shares structural similarities with the class A rhodopsin GPCR subfamily. It has 7 transmembrane domains with short N and ... TAAR1 activation mediates leukocyte chemotaxis toward TAAR1 agonists. TAAR1 agonists (specifically, trace amines) have also ... These share structural similarities with the three common monoamines: serotonin, dopamine, and norepinephrine. Each ligand has ... Rhesus monkey Taar1 and human TAAR1 share high sequence similarity, and TAAR1 mRNA is highly expressed in the same important ...
2008). "Helicobacter Flagella, Motility and Chemotaxis". Helicobacter pylori: Molecular Genetics and Cellular Biology (Yamaoka ... pylori Helicobacter species that take as part of their definition a similarity to H. pylori in being associated with the ...
Neutrophil chemotaxis is thought to be disrupted by inhibiting G-protein-coupled chemokine receptors by the ADP-ribosylation of ... Bordetella parapertussis shows the most similarity to B. pertussis and was therefore used for research determining the role of ... and interferes with the early chemokine production and the inhibition of the neutrophil chemotaxis. Chemokines are signaling ...
Receptors that bind and respond to a wide range of ligands with such seemingly different structural similarities as those of ... A final prostanoid receptor, DP2, is structurally related to the chemotaxis class of receptors and unlike the other prostanoid ... While DP1 activation causes the chemotaxis of pro-inflammatory cells such as basophils, eosinophils, and T cell lymphocytes, ...
They are able to locate these microbes through chemotaxis which is TRPV2 mediated. When the pathogen is endocytosed it is ... Specifically, the TRPV2 channel has structural similarities amongst the other members of the TRPV family. For instance, the ...
Bacetty A, Snook M, Glenn A, Noe J, Nagabhyru P, Bacon C (2009). "Chemotaxis disruption in Pratylenchus scribneri by tall ... These tests and similarities in the peptide sequences of the proteins encoded by these genes to known enzymes indicate that one ...
G protein-coupled receptor
According to the classical A-F system, GPCRs can be grouped into 6 classes based on sequence homology and functional similarity ... β-arrestin signaling mediated by the chemokine receptor CXCR3 was necessary for full efficacy chemotaxis of activated T cells.[ ... "Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation". Science Signaling. 11 ...
"Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and ... Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis. *Granulocyte, macrophage and fibroblast activation ...
Kim Y, Boyd CD, Csiszar K (1995). "A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase ... and chemotaxis to each member of the family. ...
chemotaxis. • alpha-beta T cell proliferation. • macropinocytosis. • cytoskeleton organization. • myeloid dendritic cell ... Dock2 was first characterised as one of a number of proteins which shared high sequence similarity with the previously ... In neutrophil chemotaxis Dock2 signals downstream of the C5a and CXCL8/IL-8 receptors. Additional receptors which signal ... Dock2-dependent chemotaxis has been reported in response to the chemokines CXCL12/SDF-1 in T lymphocytes, CXCL13/BLC in B ...
Respiratory syncytial virus
Several other pneumoviruses exist that show great similarity to hRSV. Most notable of these is bovine RSV (bRSV), which shares ... This binding may alter cellular chemotaxis and reduce the migration of immune cells into the lungs of infected individuals. ...
Mitochondria contain their own DNA, which has close structural similarities to bacterial DNA, and which encodes rRNA and tRNA ... as well as their being essential components of migratory responses like chemotaxis and chemokinesis. Some protists have various ... Eukaryotes and in particular akaryotes (Bacteria and Archaea) evolved through reductive loss, so that similarities result ...
These receptors do not exhibit a significant similarity in extracellular or intracellular amino acid sequence when compared to ... IL-1 and IL-6 leading to the chemotaxis of T cells, natural killer cells and monocytes to the epidermis. These cells ... similarity to IL-17A, IL-17D (25%), IL-17C (23%), and IL-17E (17%). In mammals, the sequences of these cytokines are highly ... New immature DCs are also recruited by CCL20 via chemotaxis where their activation restarts and amplifies the cycle of ...
Similarities of T cell function in cell-mediated immunity and antibody production". Cell. Immunol. 12 (1): 150-9. doi:10.1016/ ... For instance, to accurately utilize hormone terminology, cytokines may be autocrine or paracrine in nature, and chemotaxis, ...
Cannabinoid receptor type 2
The human CB1 and the CB2 receptors possess approximately 44% amino acid similarity. When only the transmembrane regions of ... leukocyte chemotaxis. • G-protein coupled receptor signaling pathway. Sources:Amigo / QuickGO. Orthologs. ... The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1 ... the receptors are considered, however, the amino acid similarity between the two receptor subtypes is approximately 68%. The ...
1995). "Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin- ... and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)". Genomics. 16 (2): 447-54. doi: ...
chemotaxis. • RNA catabolic process. • RNA phosphodiester bond hydrolysis, endonucleolytic. • positive regulation of protein ... "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology ...
The primitive P2X receptors of unicellular organisms often share low sequence similarity with those in mammals, yet they still ... On the other hand, nanomolar concentrations of adenosine activate A1 and A3 receptors, resulting in neutrophilic chemotaxis ...
Harder T, Kube E, Gerke V (Apr 1992). "Cloning and characterization of the human gene encoding p11: structural similarity to ... Falk W, Leonard EJ (May 1982). "Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement". Infection ...
The similarities between these two diseases, the corresponding success with the same mode of treatment, and the fact that the ... which specializes in neutrophil proliferation via chemotaxis (the movement of some types of cells toward or away from certain ... One of these, bare lymphocyte syndrome I (BLS I), exhibits a number of similarities with DPB in those affected, including ... The common genetic background and similarities in the HLA profile of affected Japanese and Korean individuals were considered ...
The virus genome has high similarity with human parainfluenza virus 1 (HPIV-1) and the two viruses share common antigenic ... which is involved in chemotaxis, induction of apoptosis, regulation of cell growth and mediation of angiostatic effects. Human ...
The nucleotide/ATP binding pocket is contained within the CA domain and the structural similarity of this pocket is high ... the signal-transducing protein kinase of the chemotaxis system in Escherichia coli". Biochemistry. 40 (46): 13876-87. doi: ...
The morphological similarity between chloroplasts and cyanobacteria was first reported by German botanist Andreas Franz Wilhelm ... Risser DD, Chew WG, Meeks JC (April 2014). "Genetic characterization of the hmp locus, a chemotaxis-like gene cluster that ...
When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is ... McHugh D, Tanner C, Mechoulam R, Pertwee RG, Ross RA (February 2008). "Inhibition of human neutrophil chemotaxis by endogenous ...
1972). The gradient-sensing mechanism in bacterial chemo- taxis. Proc. Natl. Acad. Sci. U.S.A. 69:2509-2512 Berg, H C and ... with a few GPCR groups being difficult to classify due to low sequence similarity, e.g. vomeronasal receptors. Other classes ...
Once believed to be a highly distinct group, larval similarities and morphological features have led researchers to believe ... bijuga indicate that the pneumatophore feature potentially also functions to sense pressure changes and regulate chemotaxis in ...
The anion K + and glutamate were used because of it similarity to the environment inside the cell, allowing coronin-1a to bind ... Yan M, Di Ciano-Oliveira C, Grinstein S, Trimble WS (May 2007). "Coronin function is required for chemotaxis and phagocytosis ... The evolutionary coronin subfamilies have been grouped by its similarities and relationships between the different proteins. ...
Characterization of a Pseudomonas aeruginosa gene cluster involved in pilus biosynthesis and twitching motility: sequence...
The sequence similarities between the putative pilG, H, I and J gene products and several established chemotaxis proteins, ... sequence similarity to the chemotaxis proteins of enterics and the gliding bacterium Myxococcus xanthus Mol Microbiol. 1994 Jan ... identical to the enteric methyl-accepting chemotaxis protein (MCP) Tsr. Mutants containing insertions in pilI and pilJ were ...
DVU0183 methyl-accepting chemotaxis protein [Desulfovibrio vulgaris str. Hildenborough] - Gene - NCBI
methyl-accepting chemotaxis protein. YP_009408.1. *identified by similarity to OMNI:PP0317; match to protein family HMM PF00015 ... Bacterial chemotaxis, conserved biosystem (from KEGG) Bacterial chemotaxis, conserved biosystemChemotaxis is the process by ... Bacterial chemotaxis, organism-specific biosystem (from KEGG) Bacterial chemotaxis, organism-specific biosystemChemotaxis is ... MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). pfam00672. Location:210 → 262. HAMP; HAMP domain ...
S1PR1 sphingosine-1-phosphate receptor 1 [Homo sapiens (human)] - Gene - NCBI
Sequence Similarity - 1NXO: MicArec pH7.0 Sequence Similarity Report Page
Chemotaxis regulator-transmits chemoreceptor signals to flagelllar motor components CheY 2336 231 1KMI 1 Y Chemotaxis protein ... Chemotaxis protein cheY homolog 210 147 4D6X 1 A, B, C, D BACTERIAL REGULATORY, FIS FAMILY PROTEIN THE GENE SEQUENCE ENCODING ... Chemotaxis protein CheY 39152 226 1DCM 1 A, B TRANSCRIPTIONAL REGULATORY PROTEIN FIXJ FIXJ RECEIVER DOMAIN (RESIDUES 1-126) 382 ... Chemotaxis protein cheY CheY 562 108 1ZH2 1 A, B KDP operon transcriptional regulatory protein kdpE N-Terminal Receiver Domain ...
CheX Is a Phosphorylated CheY Phosphatase Essential for Borrelia burgdorferi Chemotaxis | Journal of Bacteriology
Many of these genes show sequence similarity to E. coli and S. enterica serovar Typhimurium motility and chemotaxis genes (15, ... The motility and chemotaxis system of the Lyme disease spirochete B. burgdorferi is unique and complex. Motility and chemotaxis ... Swarm plate and capillary tube chemotaxis assays.Swarm plate chemotaxis assays were performed as described previously (32, 39 ... Furthermore, swarm plate and capillary tube chemotaxis assays demonstrated that cheX mutant cells were deficient in chemotaxis ...
Structure Cluster - 1I5N: Crystal structure of the P1 domain of CheA from Salmonella typhimurium 3D Similarity Report...
... structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis ... Description: CHEMOTAXIS PROTEIN CHEA protein , Length: 146 Loading... Results for domain d1i5na_. ... Structural Similarities for the Entities in PDB 1I5N. The following structural similarities have been found using the jFATCAT- ... A 40% sequence identity filter is applied before the structure alignments are calculated, so most results show low similarity. ...
RGS Molecule Expression in Murine B Lymphocytes and Ability to Down-Regulate Chemotaxis to Lymphoid Chemokines | The Journal of...
Similarity scores were calculated using Clustalw with the Blosum matrix. To obtain a probe for detecting RGS14 expression, the ... Chemotaxis assay. Chemotaxis assays were performed in 5-μm Transwell plates (Corning Costar, Cambridge, MA). Transfected cells ... 5⇓). In contrast with the effect of mouse RGS1 and mouse RGS3s, mouse RGS2 had weak effects on 2PK3 cell chemotaxis. Compared ... Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated ...
mcp-2 - Methyl-accepting chemotaxis protein - Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) - mcp...
p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.,p>,a ... PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 1 hit. PS51753. HBM. 1 hit. PS50192. T_SNARE. 1 hit. ... PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 1 hit. PS51753. HBM. 1 hit. PS50192. T_SNARE. 1 hit. ... Methyl-accepting chemotaxis proteinImported. ,p>Information which has been imported from another database using automatic ...
Rru A0755 - Chemotaxis sensory transducer - Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB...
p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.,p>,a ... Chemotaxis sensory transducerImported. ,p>Information which has been imported from another database using automatic procedures ... tr,Q2RWD6,Q2RWD6_RHORT Chemotaxis sensory transducer OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG ...
Slit: A Roadblock for Chemotaxis | Science Signaling
Molecular Vision: Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene ...
... an induced chemotaxis via P2Y purinoceptors; a mobilization of intracellular Ca2+ response via Na+/Ca2+ exchanger; and a core ... The similarities as well as alterations in gene expression among NTG, HTG, and VD groups versus controls are summarized in ... The expression similarities (altogether 34 genes) found here between glaucoma and VD versus controls indicate, on one hand, a ... Similarities in subcellular images detected in circulating leukocytes of vasospastic individuals and glaucoma patients.. DNA ...
GREM1 gene - Genetics Home Reference - NIH
Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated ... differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth ... or viability of normal cells but not transformed cells when is overexpressed (By similarity). ...
SLC8B1 Gene - GeneCards | NCLX Protein | NCLX Antibody
Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining ... Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining ... By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of ... By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of ...
Anti-CD11c antibody [N418] (Phycoerythrin) (ab210309) | Abcam
Functions: PA0174, Pseudomonas aeruginosa PAO1
Functions: PA0173, Pseudomonas aeruginosa PAO1
Bacterial chemotaxis 81.0+/01-23, Jan 17 ECO:0000249 sequence similarity evidence used in automatic assertion ... Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase 151 343 62.298 Pfam PF01339 CheB ... Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase 158 336 2.7E-62 ... Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase 157 332 1.65034E-106 ...
Distinct Chemotaxis Protein Paralogs Assemble into Chemoreceptor Signaling Arrays To Coordinate Signaling Output | mBio
... shares the most similarity with CheA4 P5 (47%). CheW1 and CheW4 share 50% sequence similarity with one another, and both CheW1 ... Chemotaxis proteins (CheA and CheW) from each of the chemotaxis signaling systems (Che1 and Che4) could physically interact ... Interaction of chemotaxis proteins from Che1 and Che4 in the bacterial two-hybrid assay. (A) Interactions between chemotaxis ... Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling proteins ( ...
Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes | Blood...
Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis. J Cell Biol. 1999;144: ... Chemotaxis assays. Monocyte migration was assessed by a 48-well microchemotaxis-chamber technique. In the lower compartment of ... Similarly to the results obtained from chemotaxis experiments, monocytes pretreated with PKC inhibitors showed a virtually ... chemotaxis, release of oxygen intermediates, enhanced phagocytosis, and bacterial killing, as well as mitogen-activated protein ...
Transient dynamic phenotypes as criteria for model discrimination: fold-change detection in Rhodobacter sphaeroides chemotaxis ...
The chemotaxis pathway of the bacterium Rhodobacter sphaeroides shares many similarities with that of Escherichia coli. It ... Chemotaxis in R. sphaeroides and in other bacteria. The chemotaxis pathway of E. coli has a well-characterized adaptation ... The homologies between the bacteria and the similarities between their overall chemotaxis mechanisms give us reason to believe ... 2013 Rhodobacter sphaeroides chemotaxis response kinetics: complexities in signalling but similarities in responses. J. R. Soc ...
Anti-C5aR/CD88 antibody (Biotin) [10/92] | Abcam
KAKEN - Research Projects | Similarities and differences of molecular mechanisms on the regulation of meristematic activity ...
Journal Article] Chemotaxis assay of plant-parasitic nematodes on a gel-filled microchannel device2015. *. Author(s). Hida, H ... Similarities and differences of molecular mechanisms on the regulation of meristematic activity. Research Project ... In this analyses, we could find that there are similarities and differences on the molecular mechanisms regulating meristematic ...
Chemotaxis can take plant-parasitic nematodes to the source of a chemo-attractant via the shortest possible routes | Journal of...
Hence, with similarity to previous modelling of ecological count data , the log-linear model fitted was. where α is a ... Nonetheless, chemotaxis has received scant attention. We show that chemotaxis is predicted to take nematodes to a source of a ... It has long been recognized that chemotaxis is the primary means by which nematodes locate host plants. Chemotaxis is a ... Chemotaxis can take plant-parasitic nematodes to the source of a chemo-attractant via the shortest possible routes. Andy M. ...
Alfred M. Spormann | Stanford Medicine Profiles
The strong similarities between the EPR signal of the benzylsuccinate synthase radical and that of the glycyl radicals of ... Bacterial chemotaxis-like sensory transduction systems control gliding motility in M. xanthus. The frz genes appear to regulate ... The two motility systems of M. xanthus are affected to different degrees by the MglA protein, which shows similarity to a small ... The high similarity between vcrABC sequences is quantitatively consistent with recent horizontal acquisition driven by ~100 ...
Books | Eisenbach
The book deals in depth with a number of different chemotaxis systems and looks for similarities and diversities between them. ... by chemotaxis. Similarly to a butterfly that is attracted to a flower by odor, or a male insect that is attracted to the female ... and cells of multicellular organisms are attracted to their targets or repelled from certain chemicals by chemotaxis. ...
Molecular cloning and characterization of a chemotactic transducer gene in Pseudomonas aeruginosa. | Journal of Bacteriology
ANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 Antibody
Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked ... Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes ... By similarity).. Miscellaneous:. *Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)- ... By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in ...
A cheZ-Like Gene in Azorhizobium caulinodans Is a Key Gene in the Control of Chemotaxis and Colonization of the Host Plant |...
The similarity between the homologous proteins is highlighted by different shading: black, all amino acids in a column are ... ORS571 CheZ plays a role in chemotaxis.To determine if strain ORS571 plays a role in chemotaxis, we constructed a mutant strain ... Chemotaxis can provide bacteria with competitive advantages for survival in complex environments. The CheZ chemotaxis protein ... Swim plate and competitive capillary assays for chemotaxis.The soft agar plate and capillary assays for chemotaxis in A. ...
Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic...
Despite many similarities between Wnt-5a and Wnt-5b, several important distinctive features were observed. First, only Wnt-5a ... Directed chemotaxis toward medium containing 200 ng/mL of CXCL12 or CCL19 (R&D Systems, 350-NS-010 and 361-MI-025) chemokines ... WNT5A-high primary CLL cells show higher basal motility and impaired chemotaxis. The association of WNT5A and WNT5B mRNA levels ... For example, we have shown previously that acute treatment by Wnt-5a can promote chemotaxis of CLL cells (8), whereas CLL cells ...
Cyria - CYFIP-related Rac1 interactor A - Mus musculus (Mouse) - Cyria gene & protein
May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and ... Lipid-anchor By similarity. Manual assertion inferred from sequence similarity toi ... May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and ... similarities target=_top>More...,/a>,/p>Sequence similaritiesi. Belongs to the CYRI family.Curated ...
Two Genes with Similarity to Bacterial Response Regulators Are Rapidly and Specifically Induced by Cytokinin in Arabidopsis |...
1986). Nucleotide sequence corresponding to five chemotaxis genes in Escherichia coli. J. Bacteriol. 165, 161-166. ... Two Genes with Similarity to Bacterial Response Regulators Are Rapidly and Specifically Induced by Cytokinin in Arabidopsis. ... Several proteins with similarity to the receiver domain of response regulators that are not fused to histidine kinase domains ... The similarity of IBC6 to bacterial response regulators, coupled with its rapid and specific induction by cytokinin, suggests ...
ProteinsMethyl-accepting chemotaxMotilityProteinSequence similarityAssaysEscherichiaReceptorReceptorsHighly conservedLeukocyteChemoreceptorsCheYPhagocytosisRegulateNeutrophilChemotacticGenesActivation of neutrophilsMonocytesPathwayGenePathwaysInduce chemotaxisMultiple chemotaxisAngiogenesisBacteria chemotaxisAminoPseudopod extensionCellsMediateInflammatory responseImmuneColonizationProliferationChemicalsInflammationAdhesionMonocyteMigrationInhibitsMechanismChemoreceptorHuman neutrophilsRegulatesStructural similaritiesColiDictyosteliumSurvivalTargets
- The sequence similarities between the putative pilG, H, I and J gene products and several established chemotaxis proteins, therefore, lend strong support to the hypothesis that these proteins are part of a signal-transduction network that controls P. aeruginosa pilus biosynthesis and twitching motility. (nih.gov)
- Chemotaxis signaling is initiated by chemoreceptors that assemble as large arrays, together with chemotaxis coupling proteins (CheW) and histidine kinase proteins (CheA), which form a baseplate with the cytoplasmic tips of receptors. (asm.org)
- The polar localization of chemoreceptors of different length classes is maintained in strains that had baseplate signaling proteins from either chemotaxis system but was lost when both systems were deleted. (asm.org)
- Chemotaxis proteins (CheA and CheW) from each of the chemotaxis signaling systems (Che1 and Che4) could physically interact with one another, and chemoreceptors from both classes present in A. brasilense could interact with Che1 and Che4 proteins. (asm.org)
- IMPORTANCE The assembly of chemotaxis receptors and signaling proteins into polar arrays is universal in motile chemotactic bacteria. (asm.org)
- We show that paralogs from two chemotaxis systems assemble together into chemoreceptor arrays, forming baseplates comprised of proteins from both chemotaxis systems. (asm.org)
- It exhibits robust adaptation and has several homologues of the latter's chemotaxis proteins. (royalsocietypublishing.org)
- The C-terminal domain of PctA showed high homology with the enteric methyl-accepting chemotaxis proteins (MCPs). (asm.org)
- Regulatory proteins associated with the twitching motility system have strong sequence and structural similarity to those that regulate bacterial chemotaxis using flagellae. (wikipedia.org)
- In contrast, over 200 bacterial gene categories were overrepresented in non-EBF+S compared to non-EBF infants including several bacterial methyl-accepting chemotaxis proteins (MCP) involved in signal transduction. (frontiersin.org)
- The LcrI deduced protein contained two hydrophobic regions most likely corresponding to the two transmembrane regions present in all of the methyl-accepting chemotaxis proteins (MCPs) which make them fold with both periplasmic and cytoplasmic domains. (asm.org)
- Ras-related proteins share significant similarities in molecular weight (20 to 25 kDa) and sequence identity (30 to 55%) with Ras proteins [ 13 ]. (hindawi.com)
- Despite possessing strong structural and biochemical similarities with Ras proteins, only a limited number of Ras-related proteins have been shown to exhibit transforming potential [ 14 ]. (hindawi.com)
- These three Vibrio proteins have amino acid sequence similarity in a region highly conserved among bacterial methyl-accepting chemotaxis proteins. (asm.org)
- Analysis of the predicted AcfB amino acid sequence suggests that this colonization determinant possesses a membrane topology and domain organization similar to those of methyl-accepting chemotaxis proteins. (asm.org)
- The relationship between AcfB and Vibrio motility and the amino acid similarities between AcfB and chemotaxis signal-transducing proteins suggest that AcfB may interact with the V. cholerae chemotaxis machinery. (asm.org)
- Genes encoding proteins involved in repairing UV-induced DNA damage and aerosolization of cells were ubiquitous across samples, and appear as fundamental requirements for the aeolian lifestyle, while genes coding for other important functions supporting the aeolian lifestyle (chemotaxis, aerotaxis, germination, thermal resistance, sporulation, and biofilm formation) varied among the communities sampled. (nature.com)
- These proteins demonstrate remarkable similarity to the chemotaxis proteins of enterics and the gliding bacterium Myxococcus xanthus and are thought to be part of a signal transduction system that controls P. (thefreedictionary.com)
- Many proteins involved in this system show widespread similarity, but several unique chemotactic genes have been identified in B. subtilis that could account for the differences in behavior and biochemistry of this organism from other chemotactic bacteria. (illinois.edu)
- One of these genes, cheD, encodes a protein that is required by the methyltransferase to methylate many of the chemoreceptors (or methyl-accepting chemotaxis proteins), probably by structural modification of the receptors upon binding. (illinois.edu)
- Specific glutamates in the methyl-accepting chemotaxis proteins (MCPs) of Escherichia coli are modified during sensory adaptation. (biomedcentral.com)
- Neutrophil-specific granule deficiency (SGD) is a rare disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. (rupress.org)
- The putative PilI protein (19,933 Da) is 28% identical to the FrzA protein, a CheW homologue of the gliding bacterium Myxococcus xanthus, and the PilJ protein (72,523 Da) is 26% identical to the enteric methyl-accepting chemotaxis protein (MCP) Tsr. (nih.gov)
- DVU0183 methyl-accepting chemotaxis protein [Desulfovibrio vulgaris str. (nih.gov)
- The key assumption of this model, which leads to FCD, is the allosteric signalling structure of the methyl-accepting chemotaxis protein receptors. (royalsocietypublishing.org)
- Binding of an attractant or repellent ligand to a specific site in the periplasmic domain of a methyl-accepting chemotaxis protein (MCP) leads to a conformational change of its cytoplasmic domain, which is transmitted to the flagellar motor by means of a series of phosphorylation reactions ( 9 , 18 , 22 ). (asm.org)
- Motility and chemotaxis are believed to be important in the pathogenesis of Lyme disease caused by the spirochete Borrelia burgdorferi . (asm.org)
- Controlling the phosphorylation state of CheY, a response regulator protein, is essential for regulating bacterial chemotaxis and motility. (asm.org)
- Wild-type chemotaxis and motility were restored when cheX mutant cells were complemented with a shuttle vector expressing CheX. (asm.org)
- These findings demonstrated that B. burgdorferi CheX is a CheY-P phosphatase that is essential for chemotaxis and motility, which is consistent with CheX being the only CheY-P phosphatase in the B. burgdorferi chemotaxis signal transduction pathway. (asm.org)
- Chemotaxis and motility are believed to be important in the pathogenesis induced by B. burgdorferi ( 10 , 13 , 36 , 45 ). (asm.org)
- In the rhizosphere, chemotaxis is used by the host - the plant - to mediate the motility of the soil which allows for microbial colonization. (wikipedia.org)
- Here, we show that a bacterium, Azospirillum brasilense , which utilizes two chemotaxis signaling systems controlling distinct motility parameters, coordinates its chemotactic responses through the production of two separate membrane-bound chemoreceptor arrays by mixing paralogs within chemotaxis baseplates. (asm.org)
- The construction of a cheZ deletion mutant strain and of cheZ mutant strains carrying a mutation in residues of the putative phosphatase active site showed that strain ORS571 participates in chemotaxis and motility, causing a hyperreversal behavior. (asm.org)
- Motile bacteria are able to seek out optimal physiological conditions through a behavior known as chemotaxis, where highly conserved signal transduction pathways couple environmental chemical gradients to cellular motility 1 , 2 . (nature.com)
- The interference with motility and chemotaxis was proposed as a strategy to block infection ( 3 ). (pnas.org)
- Abstract : We investigate the role of auto-chemotaxis in the growth and motility of an epithelium advancing on a solid substrate. (ens.fr)
- Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). (string-db.org)
- The CheZ chemotaxis protein is a phosphatase, affecting the flagellar motor in Escherichia coli by dephosphorylating the response regulator phosphorylated CheY protein (CheY∼P) responsible for clockwise rotation. (asm.org)
- SIMILARITY: Belongs to the bacterial solute-binding protein 2 CC family. (univ-lyon1.fr)
- This DNA contained an open reading frame for a 577-amino-acid protein showing several characteristics of the bacterial chemoreceptors and, therefore, we named this gene lcrI for Leptospirillum chemotaxis receptor I. This is the first sequence reported for a gene from L. ferrooxidans encoding a protein. (asm.org)
- The structural and chemical similarities of PknB to metazoan homologs support a universal activation mechanism of Ser/Thr protein kinases in prokaryotes and eukaryotes. (labome.org)
- Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum Xuehua Xu 1 , Tian Jin 1 1 Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health Here, we describe detailed live cell imaging methods for investigating chemotaxis. (jove.com)
- Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells Xi Wen 1 , Tian Jin 1 , Xuehua Xu 1 1 Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health Visual chemotaxis assays are essential for a better understanding of how eukaryotic cells control chemoattractant-mediated directional cell migration. (jove.com)
- To test the common view that Ca 2+ bursts mediate rearrangement of the actin cytoskeleton in response to the activation of G protein-coupled receptors, we combined single-cell manipulation with fluorescence imaging and monitored the Ca 2+ concentration in individual human neutrophils during complement-mediated chemotaxis. (sciencemag.org)
- In a microscopic worm known as Caenorhabditis elegans the loss of an ADAR protein called ADR-2 reduces the ability of the worm to move in response to chemicals, a process known as chemotaxis. (elifesciences.org)
- Human BCA-1 shares a 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. (prospecbio.com)
- They show little similarity to protein kinases that phosphorylate serine, threonine or tyrosine residues, but may share a distant evolutionary relationship with these enzymes. (biomedcentral.com)
- Structural comparisons with CheY from Escherichia coli shows substantial similarity in their folds, with some concerted changes propagating away from the active site that suggest how phosphorylated CheY, a signal transduction protein in bacterial chemotaxis, is recognized by its targets. (caltech.edu)
- Finally, under saline conditions, many other transcriptional responses were detected, including an increase in the transcription of genes involved in trehalose catabolism, chemotaxis and protein secretion, as well as ribosomal genes, and a decrease in the transcription of genes involved in transmembrane transport. (biomedcentral.com)
- We developed a coarse-grained method, PCalign, to quantitatively evaluate physicochemical similarities between a given pair of protein-protein interfaces. (biomedcentral.com)
- While these approaches provide insights into the mechanism of protein-protein recognition, they are not suitable for measuring similarities between a given pair of protein-protein interfaces. (biomedcentral.com)
- The latter is useful for revealing potential biological relationships between different complexes, and a suitable method to directly compare protein-protein interfaces across randomly selected protein complexes and to quantitatively assess their pairwise similarities is highly desirable. (biomedcentral.com)
- In mammals, a C1q-binding protein (C1qBP alias gC1qR), which interacts with the globular head of C1q, has been reported to participate in C1q-mediated chemotaxis of blood immune cells. (biomedcentral.com)
- Here, we demonstrate that r Hm C1q-dependent chemotaxis might be driven via a Hm C1q-binding protein located on the microglial cell surface. (biomedcentral.com)
- If the sequences are of vastly different lengths, the clustering procedure will group them in different clusters, even if they share a region of high sequence similarity. (rcsb.org)
- The most significant amino acid sequence similarity was found in the region of MCPs referred to as the highly conserved domain. (asm.org)
- Koribacter's genome encodes a candidate alpha-glucuronidase from family GH67 (plant cell wall hemicellulose degradation) that appears to share the highest sequence similarity with fungal homologs. (kenyon.edu)
- Furthermore, swarm plate and capillary tube chemotaxis assays demonstrated that cheX mutant cells were deficient in chemotaxis. (asm.org)
- Here, we describe detailed methods for: 1) real-time, high-resolution monitoring of multiple chemotaxis assays, and 2) simultaneously visualizing the chemoattractant gradient and the spatiotemporal dynamics of signaling events in neutrophil-like HL60 cells. (jove.com)
- In this study, we set to identify the cellular orthologues and receptor of vIL-8 using in silico analyses, binding and chemotaxis assays. (uni-muenchen.de)
- Chemotaxis assays were performed to investigate r Hm C1q-dependent microglia migration. (biomedcentral.com)
- Regulation of flagellar rotation and chemotaxis has been studied most extensively in Escherichia coli and Salmonella enterica serovar Typhimurium, and phosphorylation of the response regulator CheY plays an important role in regulating the swimming pattern of cells (reviewed in references 5 , 8 , 12 , 60 , 63 , and 65 ). (asm.org)
- The chemotaxis pathway of the bacterium Rhodobacter sphaeroides shares many similarities with that of Escherichia coli . (royalsocietypublishing.org)
- In contrast to Escherichia coli , a model organism for chemotaxis that has 5 chemoreceptors and a single chemosensory pathway, Pseudomonas aeruginosa PAO1 has a much more complex chemosensory network, which consists of 26 chemoreceptors feeding into four chemosensory pathways. (pnas.org)
- This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. (abcam.com)
- During chemotaxis and phagocytosis, the cells coordinate receptor-based signaling with the mechanical processes that underlie adhesion, cell deformation, and migration. (sciencemag.org)
- CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). (prospecbio.com)
- Phagocytosis and chemotaxis are receptor-mediated processes that require extensive rearrangements of the actin cytoskeleton, and are controlled by lipid second messengers such as phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] and phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4) P 2 ]. (biologists.com)
- 4 The chemotactic effect of SDF-1 is mediated by the chemokine receptor CXCR-4 (fusin, LESTR), which is expressed on mononuclear leukocytes and shows structural similarities to the IL-8 receptor. (bloodjournal.org)
- Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. (string-db.org)
- The ligand- receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. (string-db.org)
- In chemotaxis, events at the receptors control autophosphorylat. (nih.gov)
- Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). (genecards.org)
- This invention relates to novel cytokine receptors that mediate the chemotaxis and activation of monocytes, to the DNA sequences encoding the receptors and to processes for obtaining the receptors and producing them by recombinant genetic engineering techniques. (google.com)
- Crystallographic structure refinement at very high resolutions of a dozen periplasmic receptors has revealed that, though they have different sizes (26 to 60 kDa) and little sequence homology, they have high tertiary structure similarity. (nih.gov)
- The two major roles of such receptors are the modulation of chemotaxis and the generation of reactive oxygen species. (aspetjournals.org)
- The signalling domains in Aer and the chemoreceptors are highly conserved, and regulate the same chemotaxis histidine kinase system (see Wadhams and Armitage, 2004 for a review) ( Fig. 1 ). (wiley.com)
- It¿s titled: ¿The neuronal repellant Slit inhibits leukocyte chemotaxis induced by chemotactic factors. (bioworld.com)
- This similarity between the immune and nervous systems,¿ Rao continued, ¿implies new therapeutic approaches to treat diseases that involve leukocyte migration to various areas of the body. (bioworld.com)
- So if you can inhibit leukocyte chemotaxis, you might be able to treat some inflammatory and autoimmune disorders ¿ arthritis, kidney inflammation, asthma ¿ which invoke that chemotaxis. (bioworld.com)
- CCR5 plays a role in mediating leukocyte chemotaxis in response to its ligands, which include RANTES, MIP-1a, and MIP-1b. (thefreedictionary.com)
- Leukocyte Chemotaxis and Migration:Can We Follow the Cells? (asahq.org)
- Although the molecular mechanisms of leukocyte chemotaxis during inflammation have been investigated with great detail, 1 the measurement of the migration of immune cells into organs or body cavities still rely on the lavage of these cavities to obtain immune cells, or on the sampling of tissues for quantification of markers of immune cell activity, such as the myeloperoxidase produced by neutrophils. (asahq.org)
- Although leukocyte chemotaxis mediated by activated FPRL1 has been reported, the role of FPRL1 in superoxide generation remains to be studied. (aspetjournals.org)
- Placing computational evidence in the context of experimental data allowed us to conclude that three chemosensory pathways in P. aeruginosa utilize one chemoreceptor per pathway, whereas the fourth pathway, which is the main system controlling chemotaxis, utilizes the other 23 chemoreceptors. (pnas.org)
- The level of CheY phosphorylation (CheY∼P) is central to the chemotaxis signal transduction. (asm.org)
- Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). (genecards.org)
- Chemotaxis plays a part in the search for food, in fertilization in higher plants and animals, and in phagocytosis. (thefreedictionary.com)
- 11,12) The suppression of neutrophil chemotaxis and phagocytosis has been described. (thefreedictionary.com)
- May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. (uniprot.org)
- Overall, our data support a model whereby P. aeruginosa senses the surface through the Pil-Chp chemotaxis-like complex, TFP, and PilY1 to regulate cAMP and c-di-GMP production, thereby employing a hierarchical regulatory cascade of second messengers to coordinate its program of surface behaviors. (asm.org)
- 2004. Myxococcus xanthus chemotaxis homologs DifD and DifG negatively regulate fibril polysaccharide production. (asmscience.org)
- By contrast, pathological or supraphysiological concentrations of C5a often triggered Ca 2+ bursts, but pseudopod protrusion stalled or reversed in such cases, effectively halting chemotaxis, similar to sepsis-associated neutrophil paralysis. (sciencemag.org)
- WKYMVM and LXA4 stimulated neutrophil chemotaxis via tyrosine phosphorylation events. (aspetjournals.org)
- Most chemotactic motile bacteria possess multiple chemotaxis signaling systems, the functions of which are not well characterized. (asm.org)
- The genome contains full complements of flagellar and chemotaxis genes. (kenyon.edu)
- In excess of a thousand known genes encode HPKs, which are important for multiple functions in bacteria, including chemotaxis and quorum sensing, and in eukaryotes, including hormone-dependent developmental processes. (biomedcentral.com)
- GO term enrichment analysis revealed these genes to be involved in immune and inflammatory response, cell death, and chemotaxis. (biomedcentral.com)
- Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). (olink.com)
- C. jejuni isolates ( n = 45) previously analyzed for the presence of chicken colonization associated genes were further characterized for phenotypic properties influencing colonization: autoagglutination and chemotaxis as well as adhesion to and invasion of primary chicken caecal cells. (biomedcentral.com)
Activation of neutrophils2
- Lipid fractions from birch and grass pollen extracts induce chemotaxis and the activation of neutrophils ( 14 ) and eosinophils ( 15 ). (jimmunol.org)
- Previous investigations (22) showed that LTB4 is the strongest LT triggering inflammation induced by SMU, by having a significant effect on the chemotaxis and activation of neutrophils (4, 23). (thefreedictionary.com)
- Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. (proteopedia.org)
- Furthermore, it is shown that these assumptions make FCD a property of this system that is robust to structural and parametric variations in the chemotaxis pathway, in agreement with experimental results. (royalsocietypublishing.org)
- We construct and examine models of the full chemotaxis pathway that satisfy these assumptions and reproduce experimental time-series data from earlier studies. (royalsocietypublishing.org)
- The goal of this study was to look for possible similarities in gene expression profiles of circulating leukocytes in vasospastic individuals and glaucoma patients. (molvis.org)
- The assembly of paralogs from distinct chemotaxis pathways into baseplates provides a straightforward mechanism for coordinating signaling from distinct pathways, which we predict is not unique to this system given the propensity of chemotaxis systems for horizontal gene transfer. (asm.org)
- Restoring clec-41 expression in adr-2 deficient neural cells rescued the chemotaxis defect, providing the first evidence that neuronal phenotypes of ADAR mutants can be caused by altered gene expression. (elifesciences.org)
- CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). (olink.com)
- The basic organizational hierarchy of the CSU and the extended hexagonal architecture it forms appear to be universally conserved features of bacterial and archaeal chemotaxis pathways 22 , 23 . (nature.com)
- Innate inflammatory response, Th17 signalling and chemotaxis were among the pathways affected significantly. (uzh.ch)
- 8 The interaction between SDF-1 and CXCR4 leads to the activation of various intracellular signaling transduction pathways and downstream effectors that mediate cell survival, proliferation, chemotaxis, migration, and adhesion. (dovepress.com)
- methods for studying signal transduction pathways involved in chemotaxis in D. (thefreedictionary.com)
- The substances that induce chemotaxis vary from organism to organism. (thefreedictionary.com)
- Comparative genome analyses indicate that most motile bacteria possess multiple chemotaxis signaling systems, and experimental evidence suggests that signaling from distinct chemotaxis systems is integrated. (asm.org)
- Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. (olink.com)
- In the same year, another well-known study based on bacterial behavior, bacteria chemotaxis (BC), was presented by Müller et al. (hindawi.com)
- Sequence and phylogenetic analyses of all chicken CXC chemokines present in the recently published chicken genome revealed that vIL-8 shares the highest amino acid similarity with the CXCL13L1 variant. (uni-muenchen.de)
- BMPs are categorized into four subgroups based on the structure, amino acid and the similarity of the nucleotide. (alliedacademies.org)
- Ogihara, S. Actin polymerization and pseudopod extension during amoeboid Chemotaxis. (springer.com)
- The maximum increase in cell surface area during pseudopod extension in pure chemotaxis was much smaller-by a factor of 8-than the known capacity of adherent human neutrophils to expand their surface. (sciencemag.org)
- Bacterial chemotaxis, organism-specific biosystem Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. (nih.gov)
- Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). (nih.gov)
- Similarly to a butterfly that is attracted to a flower by odor, or a male insect that is attracted to the female by pheromones, many organisms (primarily, but not solely, unicellular) and cells of multicellular organisms are attracted to their targets or repelled from certain chemicals by chemotaxis. (weizmann.ac.il)
- In contrast to the run-and-tumble model of chemotaxis associated with flagellated cells however, movement towards chemoattractants in twitching cells appears to be mediated via regulation of the timing of directional reversals. (wikipedia.org)
- Liotta, L.A. Signal transduction for Chemotaxis and haptotaxis by matrix molecules in tumor cells. (springer.com)
- Segall, J.E. Chemotaxis of metastatic tumor cells: Clues to mechanisms from the Dictyostelium paradigm. (springer.com)
- In addition, the chemokines not only bound the target cells but also induced chemotaxis. (uni-muenchen.de)
- Female sexual cells of the aquatic fungus Allomyces release the isoprenoid syrenin, a stimulus of chemotaxis of male sexual cells toward female cells. (thefreedictionary.com)
- RacG-KO cells showed a moderate chemotaxis defect that was stronger in the RacG-V12 and RacG-N17 mutants, in part because of interference with signaling through Rac1. (asm.org)
- This r Hm C1q-induced chemotaxis was reduced when cells were preincubated with either anti- Hm C1q or anti-human C1qBP antibodies. (biomedcentral.com)
- These cell pole-localized arrays mediate sensing, signaling, and signal amplification during chemotaxis responses. (asm.org)
- Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). (genecards.org)
- The immune system and nervous system display striking similarities. (sciencemag.org)
- In the phycosphere, the phytoplankton release of specific chemical exudates elicits a response from bacterial symbionts who exhibit chemotaxis signaling, thereby enabling the recruitment of microbes and subsequent colonization. (wikipedia.org)
- Here, we investigate the self-organization of expanding bacterial colonies under chemotaxis, proliferation and eventually active-reaction. (ens.fr)
- A continuous model is proposed where the coupling between the cellular proliferation, the friction on the substrate and chemotaxis is investigated. (ens.fr)
- According to our results, the friction and proliferation stabilize the front whereas auto-chemotaxis is a factor of destabilization. (ens.fr)
- Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). (olink.com)
- When this movement is in response to chemicals, the process is termed chemotaxis. (asm.org)
- This suggests that water-soluble chemicals are used mainly for short-range chemotaxis to plant roots, and that volatile chemicals can be used for longer range chemotaxis to distant plant roots. (royalsocietypublishing.org)
- Localization of the inflammation in the caecum and its similarities to IBD make this model particularly suitable to study TSO therapy in vivo. (uzh.ch)
- It is especially important in monocyte adhesion and chemotaxis. (abcam.com)
- Acts as inhibitor of monocyte chemotaxis. (nih.gov)
- Using a transient transfection approach in a mature B cell line, 2PK3, we demonstrate that RGS1 and RGS3s are effective inhibitors of chemotaxis toward the lymphoid tissue chemokines stromal cell-derived factor-1, B lymphocyte chemoattractant, and EBV-induced molecule 1 ligand chemokine, whereas RGS2 has a minimal effect on migration to these chemokines. (jimmunol.org)
- BCO is based on a lifecycle model that simulates some typical behaviors of E. coli bacteria during their whole lifecycle, including chemotaxis, communication, elimination, reproduction, and migration. (hindawi.com)
- Given these data, it is conceivable that axon formation has similarities, both conceptual and mechanistic, to the cell polarization observed during cell migration ( Li and Gundersen, 2008 ). (jneurosci.org)
- Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). (proteopedia.org)
- A newly created chemotaxis strategy combined with communication mechanism is developed to simplify the bacterial optimization, which is spread over the whole optimization process. (hindawi.com)
- The involvement of a C1qBP-related molecule in this chemotaxis mechanism was assessed by flow cytometry and with affinity purification experiments. (biomedcentral.com)
- FUNCTION: Involved in the high-affinity D-ribose membrane CC transport system and also serves as the primary chemoreceptor for CC chemotaxis. (univ-lyon1.fr)
- To investigate the physiological role of intracellular calcium (Ca 2+ ) bursts in this complex behavior, Francis and Heinrich presented nonadherent human neutrophils with various targets that induced complement-mediated chemotaxis. (sciencemag.org)
- The following structural similarities have been found using the jFATCAT-rigid algorithm [ 1 , 2 ]. (rcsb.org)
- Although significantly more complex, the chemotaxis system of the bacterium Rhodobacter sphaeroides has many similarities to that of E. coli . (royalsocietypublishing.org)
- Most of the current knowledge of mechanisms of amoeboid Chemotaxis is derived from studies of PMN leukocytes and Dictyostelium amoebae, which have revealed many similarities between the two different eukaryotic models. (springer.com)
- Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). (genecards.org)
- Chemotaxis can provide bacteria with competitive advantages for survival in complex environments. (asm.org)
- Caenorhabditis elegans lacking ADARs exhibit reduced chemotaxis, but the targets responsible for this phenotype remain unknown. (elifesciences.org)